CN101491599B - Composite decoction of herba pyrrosiae and lysimachia capable of treating ureteral calculi - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine formulas, in particular to compound pyrrosia lingua desmodium soup for eliminating ureteral calculus. Herba pyrrosiae, desmodium, ventriculi galli mucosa, radices cyathulae, radices paeoniae rubra, radices paeoniae alba, radix glycyrrhizae preparata, dandelion, herba dianthi, pencil stone and torrefied rhubarb are used as raw materials; the ventriculi galli mucosa is smashed; the smashed ventriculi galli mucosa and the herba pyrrosiae, the desmodium, the radices cyathulae, the radices paeoniae rubra, the radices paeoniae alba,the radix glycyrrhizae preparata, the dandelion, the herba dianthi, the pencil stone and the torrefied rhubarb are soaked with water and decocted; and residue is removed to obtain a filtrate so as toprepare the compound pyrrosia lingua desmodium soup. The compound herba pyrrosiae desmodium soup is characterized in that the soup comprises the following raw material compositions in percentage by weight: 5 to 8 percent of the pyrrosia lingua, 15 to 20 percent of the desmodium, 5 to 8 percent of ventriculi galli mucosa, 5 to 8 percent of the medicinal cyathula root, 8 to 12 percent of the radices paeoniae rubra, 8 to 12 percent of the radices paeoniae alba, 2 to 5 percent of the radix glycyrrhizae preparata, 15 to 20 percent of the dandelion, 5 to 8 percent of the herba dianthi, 10 to 15 percent of the pencil stone and 2 to 5 percent of the torrefied rhubarb. The compound herba pyrrosiae desmodium soup has low cost, high treatment effect of treating ureteral calculus, no toxicity and no side effect, has the functions of diminishing inflammation and resisting infection and is suitable for nephrolith, ureteral calculus, vesical calculus and urethral calculus.

Description

The compound pyrrosia leaf Herba Lysimachiae soup of a kind ofization ureteral calculus

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically the compound pyrrosia leaf Herba Lysimachiae soup of a kind ofization ureteral calculus.

Background technology

As everyone knows, ureteral calculus deserves to be called lithangiuria again, and cardinal symptom is pain and hematuria, and whether its degree reached not damaged with stone location, size, activity, it is relevant to infect, block etc.Ureteral calculus can cause renal colic, typically shows as severe pain unbearably, and the paroxysmal outbreak is positioned at waist or epigastrium, and along the ureter conduct, is radiated to the homonymy groin, also can involve homonymy testis or labia.Calculus is at the stage casing ureter, and pain is radiated to middle hypogastric region, and calculus is in tubal bladder wall section or ureteric orifice, can levy and urethra and penis head radiating pain with bladder irritation.Renal colic is common in the calculus activity and causes the situation of ureteral obstruction.Usually patient has gross hematuria or microscopic hematuria, and movable sometimes back microscopic hematuria is unique clinical manifestation of going up lithangiuria.Ureteral calculus causes when urinary tract blocks fully, the ureteral lumen internal pressure is increased, and tube wall differentially expanding, spasm and ischemia are owing to ureter and intestinal have common innervation to cause feeling sick, vomitting, when calculus companion infection or tubal bladder wall section calculus, frequent micturition, urgent micturition, dysurea can be arranged.When calculus secondary acute pyelonephritis or pyonephrosis, General Symptomies such as heating, fear of cold, shiver with cold can be arranged.When lithangiuria causes on bilateral complete obstruction or isolated, the kidney urinary tract complete obstruction on the bilateral, can cause anuria, uremia occur and threat to life.The method of clinical treatment ureteral calculus mainly is operation, brings great misery and spirit, economically burden to patient.For this reason, we excavate motherland's medical treasure-house, the utilization theory of Chinese medical science, and gathering 11 kinds of Chinese herbal medicine, to fry in shallow oil soup oral, the Clinical Practice confirmation, determined curative effect is for a kind of new method has been created in the treatment of ureteral calculus.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, provide that a kind of cost is low, treatment ureteral stones height, have no side effect, have antiinflammatory, anti-infective effect, be applicable to renal calculus, ureteral calculus, vesical calculus and calculus of urethra.

The technical scheme that the present invention solves the problems of the technologies described above employing is: the compound pyrrosia leaf Herba Lysimachiae soup of a kind ofization ureteral calculus, adopt Folium Pyrrosiae, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is a raw material, Endothelium Corneum Gigeriae Galli is disturbed, with Folium Pyrrosiae, Herba Lysimachiae, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is soaked in water, remove slag after decocting filtrate, promptly make compound pyrrosia leaf Herba Lysimachiae soup, it is characterized in that the raw material composition is by weight percentage: Folium Pyrrosiae is 5～8%, Herba Lysimachiae 15～20%, Endothelium Corneum Gigeriae Galli 5～8%, Radix Cyathulae 5～8%, Radix Paeoniae Rubra 8～12%, the Radix Paeoniae Alba 8～12%, Radix Glycyrrhizae Preparata 2～5%, Herba Taraxaci 15～20%, Herba Dianthi 5～8%, Talcum 10～15%, Radix Et Rhizoma Rhei (parched) 2～5%.

Effect of the present invention is that cost is low, treatment ureteral stones height, has no side effect, and has antiinflammatory, anti-infective effect, is applicable to renal calculus, ureteral calculus, vesical calculus and calculus of urethra.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1: adopting Folium Pyrrosiae, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is that raw material preparing forms.Its component (weight %) is Folium Pyrrosiae 7.3, Herba Lysimachiae 18.3, Endothelium Corneum Gigeriae Galli 6.1, Radix Cyathulae 6.1, Radix Paeoniae Rubra 9.1, the Radix Paeoniae Alba 9.1, Radix Glycyrrhizae Preparata 3.7, Herba Taraxaci 18.3, Herba Dianthi 6.1, Talcum 12.2, Radix Et Rhizoma Rhei (parched) 3.7 for every pair.Getting above-mentioned 11 kinds of raw material gross weights is 164 grams, at first Endothelium Corneum Gigeriae Galli is smashed to pieces, at room temperature 11 kinds of Chinese herbal medicine are added water to 600～800ml, soaked 4～6 hours, decoct about 90～120 minutes with slow fire then, remove slag about filtrate 150ml, medicinal residues add water 200～300ml again, decoct 30～40 minutes, remove slag filtrate 50～70ml, altogether 200～220ml left and right sides medicine juice, promptly make compound pyrrosia leaf Herba Lysimachiaeization ureteral calculus soup.Pack in the aseptic vial, seal bottle cap is standby, and every day, 1 dose of branch 2 times was oral, each (medicine) being taken before meal 100～110ml, and clinical symptoms of taking and sign disappear, and after the calculus shade disappears under the X line, consolidate curative effect again and take for 1 week.

Principal agent Folium Pyrrosiae of the present invention: nature and flavor are sweet, bitter, be slightly cold, and return lung, urinary bladder channel.Have relieving stranguria by diuresis, preventing phlegm from forming and stopping coughing, lung heat clearing, expel the heat-evil, the function of clearing away heat to stop bleeding, be used for pyretic stranguria, stranguria caused by urinary stone, urinary obstruction, odynuria, haematemesis, hematuria etc.Chemical constituent contains compositions such as saponin, anthraquinone, tannin, low grade sugar and flavone, chimonin, triterpenoid compound.Its pharmacological action has elimination or gets rid of urinary stone, diuresis, and the urine amount significantly increases after the medication, and edema disappears, and to reducing urine protein, erythrocyte, elimination or reducing granular pattern hematuria, reduction non-protein nitrogen etc. better effect is arranged; The Herba Lysimachiae nature and flavor are sweet, salty, be slightly cold, and return liver, gallbladder, kidney urinary bladder channel, have eliminating damp-heat, treating stranguria, repercussive function, are used for pyretic stranguria, liver and bile stone, lithangiuria etc.Chemical constituent contains acid ingredient, sterol, flavonoid, aminoacid, tannin, volatile oil and choline etc.To Herba Lysimachiae diuresis and expelling stone mechanism, have data to think that Herba Lysimachiae can make the urine souring after oral, so can impel the litholysis that could exist in alkaline environment, Herba Lysimachiae can suppress water, calcium oxalate crystal increases, inhibitory action increases with the increase of concentration, and has the effect of cholagogic and lithagogue; Endothelium Corneum Gigeriae Galli is the gizzard tunica intima of Phasianidae animal man chicken, and nature and flavor are sweet, flat, return spleen, small intestinal, urinary bladder channel.Function with promoting digestion and invigorating the stomach, arresting seminal emission is used for the emission and spermatorrhea of bladder distension, instability of kidney QI.This product contains gastric hormone, fish protein, 17 seed amino acids, pepsin and amylase, can promote gastric secretion, and gastric enzyme concentration is increased, and eupepsy strengthens, and promotes gastrointestinal peristalsis to accelerate, and quickens gastrointestinal emptying; Radix Cyathulae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae, and sweet, the little hardship of its nature and flavor, flat is returned liver, kidney channel.Function with eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome is used for that arthralgia, flaccidity of the lower limbs muscle are twin, hematuria stranguria with blood, injury from falling down etc.; Radix Paeoniae Rubra nature and flavor hardship, be slightly cold, return Liver Channel.Function with clearing away heat and cooling blood, eliminating stasis to stop pain is used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, stagnation of liver-QI costalgia, dysmenorrhea amenorrhea, injury from falling down, carbuncle skin infection.In the Radix Paeoniae Rubra compounds identified mostly be the monoterpene composition, the effect that has antiinflammatory, separates spasm and human body immunity improving.Radix Paeoniae Rubra has obvious potentiation to hepatocyte DNA synthetic, and the liver hydrolytic process is had facilitation, helps poisonous substance and drains.Radix Paeoniae Alba nature and flavor hardship, acid, be slightly cold, return liver, spleen channel.Have effects such as suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, antibiotic, thrombocytosis.Be used for that liver rib pain, dysentery stomachache, night sweat, fever due to yin deficiency, metrorrhagia, leukorrhagia, headache are dizzy, limb pain twin etc.The influence of Radix Paeoniae Alba pair cell immunity, but its water decoction antagonism cyclophosphamide makes it to recover normal level to the inhibitory action of mice periphery blood T lymphocyte, shows that the Radix Paeoniae Alba can make the cellular immune function that is in low state recover normal.Staphylococcus, first type and beta hemolytic streptococcus, Diplococcus pneumoniae, dysentery bacterium, typhoid fever Salmonella paratyphi, escherichia coli, bacillus pyocyaneus etc. all there is obvious inhibitory action.Radix Paeoniae Alba extract has remarkable inhibitory action to the impatient property of rat Ovum Gallus domesticus album inflammation edema.The Radix Paeoniae Alba has significant analgesia, lowers the temperature, separates the spasm effect.The writhing response that the paeoniflorin Dichlorodiphenyl Acetate causes has significant analgesia role, share with the methanol complex of Radix Glycyrrhizae, and the two Dichlorodiphenyl Acetate writhing response has the synergic antalgic effect.Main component paeoniflorin in the Radix Paeoniae has spasmolysis preferably, and can obviously improve the anoxia toleration.The Radix Glycyrrhizae Preparata nature and flavor are sweet, flat, GUIXIN, lung, taste warp.Have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for the various middle and advanced stage diseases that deficiency of QI in middle-JIAO, deficiency of vital energy blood decline, control insufficiency of the spleen weak, lack of appetite stomachache loose stool, overstrain heating etc.Its chemical constituent of Radix Glycyrrhizae is mainly triterpenes, flavonoid, alkaloid and polysaccharide etc., has tangible antiviral, antibiotic, antiinflammatory, separates spasm, improves cellular immunization and the anti-frightened function of antipyretic-antalgic.Herba Taraxaci nature and flavor hardship, sweet, cold is returned liver, stomach warp.Function with heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation is to acute mastitis, lymphadenitis, acute conjunctivitis, cold, fever, conjunctival congestion, pharyngalgia, lung abscess, jaundice due to damp-heat, the puckery pain of pyretic stranguria etc.Its chemical constituent contains taraxasterol, choline, inulin, pectin etc.This product is broad-spectrum antiseptic, staphylococcus aureus, Bacillus typhi, bacillus pyocyaneus is had inhibitory action.In-vitro antibacterial experimental results show that Herba Taraxaci has antibacterial potentiation, and the compound dandelion bacteriostatic activity strengthens.Hepatic cholagogic, antiendotoxic effect are arranged.Remarkable anti-pyloric ligation ulcer effect is arranged, and damage also has good anti-damaging action to the dehydrated alcohol gastric mucosa.Herba Dianthi nature and flavor hardship, cold, GUIXIN, small intestinal, kidney, urinary bladder channel.Have the function that relieving stranguria by diuresis, removing blood stasis stimulate the menstrual flow, be used for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, acute urethritis, cystitis, odynuria, carbuncle, edema, eczema, scratch where it itches, conjunctival congestion, contamination sore etc.Contain triterpenoid saponin thing, Diranthus chinensis etc. in its chemical constituent.The Herba Dianthi decoct has significant diuresis, and staphylococcus aureus, Bacillus typhi, escherichia coli, bacillus pyocyaneus, shigella flexneri, Bacillus proteus etc. are had inhibitory action.Talcum: nature and flavor are sweet, light, cold, go into stomach, urinary bladder channel.Have clearing away heat and promoting diuresis, treating strangurialy quench the thirst, function such as expelling summer-heat eliminating dampness by diuresis, dysuria, watery diarrhea, hematodiarrhoea, gonorrhea, jaundice, edema etc. are had obvious therapeutic action.Chemical constituent master's magnesium silicate, kaolinate.Pulvis Talci can a large amount of chemical irritants of sorption or poisonous substance because granule is little, and the gross area is big, therefore, when spreading during in inflammation or damaged tissue surface, the effect of protection can be arranged.Remove the gastrointestinal mucosa of protection inflammation when for oral administration and bring into play that tell in the town, anti-diarrhea effect, can also stop the absorption of poisonous substance in gastrointestinal tract.Can treat that urinary system is hemorrhage, the visible hematuria of naked eyes etc.Radix Et Rhizoma Rhei (parched): nature and flavor hardship, cold, return spleen, stomach, large intestine, liver, pericardium channel.Function with expel the heat-evil logical intestinal, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation is used for prominent hot constipation, jaundice due to damp-heat, conjunctival congestion pharyngeal swelling, abdominalgia with intestinal abscess, edema, traumatic injury etc.Its pharmacological action has antibacterial action, and hepatic injury is had significant protective effect, is significantly increased the composition of bile secretion, can prevent acute edema type or downright bad pancreatitic generation of type of acute hemorrhage and development that trypsin or ethanol bring out.Have that antibiotic, antiinflammatory, hemostasis are invigorated blood circulation, analgesic cooling and diuresis separate the effect of spasm analgesic.The ingenious prescription of 11 flavor Chinese herbal medicine, the mutual coordinative role of medicine, the specially good effect of playing ureteral calculus altogether.

Embodiment 2: adopting Folium Pyrrosiae, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is that feedstock production forms.Its component (weight %) is Folium Pyrrosiae 7.9, Herba Lysimachiae 19.4, Endothelium Corneum Gigeriae Galli 5.7, Radix Cyathulae 5.7, Radix Paeoniae Rubra 8.9, the Radix Paeoniae Alba 8.9, Radix Glycyrrhizae Preparata 3.8, Herba Taraxaci 18.1, Herba Dianthi 5.7, Talcum 12.4, Radix Et Rhizoma Rhei (parched) 3.5 for every pair.Getting above-mentioned 11 kinds of raw material gross weights is 164 grams, at first Endothelium Corneum Gigeriae Galli is smashed to pieces, under the greenhouse, 11 kinds of Chinese herbal medicine are added water to 600～800ml, soaked 4～6 hours, decoct about 90～120 minutes with slow fire then, remove slag about filtrate 150ml, medicinal residues add water 200～300ml again, decoct 30～40 minutes, remove slag filtrate 50～70ml, twice medicinal liquid mix homogeneously, altogether 200～220ml left and right sides medicine juice, promptly make compound pyrrosia leaf Herba Lysimachiaeization ureteral calculus soup.Pack in the aseptic vial, seal bottle cap is standby, and every day, potion was oral at twice, about each (medicine) being taken before meal 100～110ml, takes to clinical symptoms and sign and disappears, and after the calculus shade disappears under the X line, takes for 1 week consolidating curative effect.

But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (percentage by weight) is realized, this compound pyrrosia leaf Herba Lysimachiae soup is people and different due to illness, only adjust the addition of Folium Pyrrosiae, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched), it is identical with embodiment 1 or embodiment 2 that other decoct program, and its content is as shown in the table.

Below in conjunction with my institute, i.e. the clinical trial carried out of Shandong Province Wendeng Central Hospital, Weihai City is done further, is described in detail the present invention:

1, case is selected: this organizes 60 examples, age 21-57 year, wherein male 34 people, women 26 people, renal calculus patient's 6 examples, ureteral calculus patient 18 examples, vesical calculus patient's 23 examples and calculus of urethra patient 13 examples.

2, Therapeutic Method:

Every day potion divide 2 times oral, each (medicine) being taken before meal 100～110ml sooner or later, takes nine courses of treatment altogether at one Zhou Weiyi the course of treatment.

3, therapeutic effect: use compound pyrrosia leaf Herba Lysimachiae soup agent of the present invention to treat 60 examples altogether, the result cures 53 examples fully, effective 4 examples, invalid 3 examples, what wherein renal calculus was invalid is 1 example, what calculus of urethra was invalid is 2 examples, ureteral calculus effectively is 3 examples, and calculus of urethra effectively is 1 example, and surplus person cures fully, effective percentage is 95%, and inefficiency is 5%.

Claims (1)

1. compound pyrrosia leaf Herba Lysimachiae soup of changing ureteral calculus, adopt Folium Pyrrosiae, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is a crude drug, Endothelium Corneum Gigeriae Galli is disturbed, with Folium Pyrrosiae, Herba Lysimachiae, Radix Cyathulae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Herba Taraxaci, Herba Dianthi, Talcum, Radix Et Rhizoma Rhei (parched) is soaked in water, remove slag after decocting filtrate, promptly make compound pyrrosia leaf Herba Lysimachiae soup, it is characterized in that the crude drug composition is by weight percentage: Folium Pyrrosiae is 5～8%, Herba Lysimachiae 15～20%, Endothelium Corneum Gigeriae Galli 5～8%, Radix Cyathulae 5～8%, Radix Paeoniae Rubra 8～12%, the Radix Paeoniae Alba 8～12%, Radix Glycyrrhizae Preparata 2～5%, Herba Taraxaci 15～20%, Herba Dianthi 5～8%, Talcum 10～15%, Radix Et Rhizoma Rhei (parched) 2～5%.