CN104491104A - Traditional Chinese medicine composition for treating bedsore in clinical care - Google Patents
Traditional Chinese medicine composition for treating bedsore in clinical care Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine and discloses a traditional Chinese medicine composition for treating bedsore in clinical care. Specifically, the traditional Chinese medicine composition for treating bedsore in clinical care is prepared from the following traditional Chinese medicinal materials in parts by weight: 40-80 parts of humifuse euphorbia herb, 40-80 parts of cortex phellodendri, 40-80 parts of radix scutellariae, 20-40 parts of cortex moutan, 20-40 parts of Chinese gall, 10-36 parts of frankincense, 10-36 parts of myrrh, 10-28 parts of flos lonicerae, 10-28 parts of radix arnebiae and 5-28 parts of radix sophorae flavescentis. Through mutual cooperation and interaction of the 10 medicinal materials, the traditional Chinese medicine composition disclosed by the invention has the functions of clearing heat and removing toxicity, activating blood and resolving stasis, resisting and inhibiting bacteria, stopping and treating pain, healing up sore and diminishing swelling and eliminating putridity and promoting granulation, can improve the blood circulation of the pressed tissues of long-term bedridden patients and promote quick growth of epithelial cell tissues, and has the advantages of short treatment course, high cure rate and rare relapse after cure.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to Chinese medicine composition being used for the treatment of decubital ulcer and preparation method thereof in a kind of clinical care.
Background technology
Pressure ulcer, also known as pressure ulcer, decubital ulcer, is due to the long-term pressurized of local organization, and continuous ischemia, anoxia, malnutrition and cause tissue fester's necrosis occur.Pressure ulcer is the problem of a universality in rehabilitation, nursing.According to related documents, 60,000 people are about had to die from pressure ulcer concomitant symptoms every year.
Decubital ulcer is mainly in the easily pressurized position such as tail sacrum, elbow ankle, ridge more, and with skin ulceration, the open sore part is prolonged is not more feature.At present, the treatment of decubital ulcer belongs to one difficult medical problem, and the state of an illness is once form huge decubital ulcer, and treatment cycle is long, and medical expense is also very large.Very easily there is wound infection, even cause fatal septicemia in decubital ulcer after worsening broken skin.Decubital ulcer primary treatment regimen takes infrared ray radiation, puts Gentian Violet and excision on the skin, and in row, thick skin-grafting or flap, muscle flap, musculo cutaneous flap Shift recovery are main, there is the shortcomings such as treatment time length, weak effect.
Traditional Chinese medical herbal treatment decubital ulcer has unique treatment advantage, and in recent years, the medicine of numerous treatment decubital ulcer is in the news out, and so these medicine ubiquity flavour of a drug are various, and formula is complicated, and raw medicinal material not easily obtains, preparation difficulty shortcoming.
Summary of the invention
The object of this invention is to provide the Chinese medicine composition a kind of clinical care being used for the treatment of decubital ulcer.
In order to realize object of the present invention, the invention provides the Chinese medicine composition a kind of clinical care being used for the treatment of decubital ulcer, it is made up of following Chinese crude drug:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis.
Preferably, clinical care of the present invention is used for the treatment of the Chinese medicine composition of decubital ulcer, it is made up of the Chinese crude drug of following weight proportioning:
Preferably, clinical care of the present invention is used for the treatment of the Chinese medicine composition of decubital ulcer, it is made up of the Chinese crude drug of following weight proportioning:
Fang Zhong, Herba Euphorbiae Humifusae: nature and flavor, pungent, flat.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.Cortex Phellodendri: nature and flavor, bitter, cold.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.Radix Scutellariae: nature and flavor is bitter, cold.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Cortex Moutan: nature and flavor, bitter, pungent, be slightly cold.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.Galla Chinensis: nature and flavor is sour, puckery, cold.Astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stops blooding, removing dampness sore.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.Olibanum: nature and flavor, acrid in the mouth; Bitter; Tepor.Blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.Main trusted subordinate's pain; Rheumatic arthralgia; Amenorrhea dysmenorrhea; Traumatic injury stasis of blood pain; Swollen ulcer drug; Intestinal carbuncle; The sore being festered and unhealed.Myrrha: nature and flavor is bitter; Flat.Promoting blood circulation and stopping pain; Detumescence and promoting granulation.Main breast abdomen stasis of blood pain; Dysmenorrhea; Amenorrhea; Lump in the abdomen; Traumatic injury; Carbuncle skin infection; Intestinal carbuncle; Conjunctival congestion and swelling pain.Flos Lonicerae: nature and flavor, sweet, cold.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.Radix Arnebiae (Radix Lithospermi): nature and flavor is sweet, salty, cold.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Radix Sophorae Flavescentis: nature and flavor is bitter, cold.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Present invention also offers the preparation method of the Chinese medicine composition a kind of clinical care being used for the treatment of decubital ulcer, it is characterized in that, comprise following steps
Take above-mentioned weight ratio Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis, put into reducing mechanism and be ground into coarse powder, add the 60%-80% ethanol of medical material total weight parts 4 times amount, stir 5-30 minute, be heated to 60-80 degree Celsius, insulation 2-8 hour, filtered while hot obtains filtrate, by filtrate fill spray bottle.Preferably, the alcohol concentration added is 70%-75%.Most preferably, the alcohol concentration added is 75%.
The present inventor also finds, when heating-up temperature is more than 80 degrees Celsius, drug effect can reduce greatly, more than 90 degrees Celsius, and drug action subsides, therefore heating-up temperature is no more than 80 degrees Celsius.So when temperature is lower than 60 degrees Celsius, effective ingredient stripping is less, does not have therapeutical effect, and cross and consider, above-mentioned heating-up temperature need control to be advisable at 60-80 degree Celsius.
The percentage ratio of ethanol of the present invention is percent by volume.
Through clinical verification, Chinese medicine composition of the present invention, compared with existing medicine, has following beneficial effect:
1. in side of the present invention, 10 taste medical materials can be worked in coordination with mutually, interact, and have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, antibacterial bacteriostatic, pain relieving control pain, healing up sore and subduing swelling, the effect of putrefaction-removing granulation-promoting, can improve the blood circulation of patient bedridden in long term pressurized tissue, promotes that epithelial cell tissues grows fast.
2. Chinese medicine composition of the present invention, effective percentage is high, instant effect, does not recur, short treating period, alleviates patient's misery, and the labor intensity of nursing staff.
3. Chinese medicine composition medication of the present invention is simplified, and flavour of a drug are few, and crude drug source used is extensive, without in great shortage.
Clinical data
Decubital ulcer has another name called " bed-sore ".Many because of prolonged illness bed, QI-blood circulation is lost smooth, failure of skin and muscle to be nourished, and often because friction skin is broken, contamination forms.Be mainly in the easily pressurized position such as tail sacrum, elbow ankle, ridge, with skin ulceration, the open sore part is prolonged is not more feature.
1 object and method
1.1 objects: select outpatient service and inpatient totally 142 examples, be the decubital ulcer that local skin pressurized causes, all meet the diagnosis about decubital ulcer in " tcm internal medicine disease Standardization of diagnosis and curative effect ": be apt to occur in the apophysis such as tail sacrum, ridge, elbow ankle and easily suffer oppression and the position that rubs; From the beginning of skin occurring brown erythema, micro-swollen, purple dark edema then, necrosis is festered; During secondary contamination, tissue necrosis is rapid, and pus is dripping, corresponding site Bing Fa Xing core pain; Be more common in the patient of the prolonged illness beds such as stupor, paralysis, fracture, large-area burns.
All patients are divided into two groups at random:
Treatment group 71 example, man 38 example, female 33 example; Age 57-88 year, 70.2 years old mean age; According to decubital ulcer staging scale in " basic nursing operation code ": I phase 15 example, II phase 14 example, III phase 30 example, IV phase 12 example.
Matched group 71 example, man 38 example, female 33 example; Age 58-90 year, 70.5 years old mean age; According to decubital ulcer staging scale in " basic nursing operation code ": I phase 14 example, II phase 15 example, III phase 31 example, IV phase 11 example.
Two groups of sexes, age, the state of an illness, body constitution, nutriture, decubital ulcer position, Area comparison, no significant difference (P > 0.05), has comparability.
1.2 method
1.2.1 treatment group: give spray treatment prepared by the embodiment of the present invention 1, every day 3-6 time, twice at least 3 hours medication interval time, squirt affected part at every turn; Asepsis injector teasing blister epidermis need be used to be released by the liquid oozed out if any blister person, with the least possible destruction blister epidermis for principle, medicine can be made like this to infiltrate skin and can reduce again the invasion and attack of wound surface by antibacterial.
1.2.2 matched group: with iodine tincture coating wound surface after the skin before treatment around routine disinfection decubital ulcer, local is with the bedsore wound soak of tobramycin 80,000 unit.Every day 2 times, each 2 hours.
Treat 8 days all continuously for two groups.
1.2.3 criterion of therapeutical effect: draft with reference to " clinical disease diagnosis and curative effect judging standard ".
Cure: the ulcer open sore part forms a scab and comes off, and local organization is repaired completely;
Effective: ulcer forms a scab, and ulcer area reduces;
Effective: ulcer area reduces, shoal, exudate reduces;
Invalid: local is unchanged or increase the weight of.
1.2.4 statistical analysis, adopts SPSS16.0 to carry out statistical analysis.
2, experimental result
2.1 liang of group Clinical efficacy comparisons: add up after medication 8d, clinical efficacy is in table 1.
Table 1 liang group Clinical efficacy comparison
| Group | Number of cases | Cure (cure rate) | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 71 | 39(54.9％) * | 18 | 12 | 2 | 97.2％ * |
| Matched group | 71 | 25(35.2％) | 17 | 10 | 19 | 73.2％ |
Note: * P < 0.05 more flat with matched group
Treatment group cure rate (54.9%) is apparently higher than matched group cure rate (35.2), and P < 0.05, has statistical significance.Treatment group total effective rate (97.2) is apparently higher than matched group total effective rate (73.2), and P < 0.05, has statistical significance.Illustrate that the Chinese medicine composition that the present invention treats decubital ulcer has good therapeutical effect.
2.2 adverse reaction rates: two groups all do not find obvious adverse reaction.
2.3 recurrences: the routine patient of matched group 39 carries out tracing observation 3 months, has no recurrent cases.
Detailed description of the invention
Explain the present invention further below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
Embodiment 1
Prescription (weight portion):
Preparation method:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis is taken by above-mentioned weight ratio, put into reducing mechanism and be ground into coarse powder, add 75% ethanol of medical material total weight parts 4 times amount, stir 10 minutes, be heated to 70 degrees Celsius, be incubated 4 hours, filtered while hot obtains filtrate, by filtrate fill spray bottle.
Embodiment 2
Prescription (weight portion):
Preparation method:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis is taken by above-mentioned weight ratio, put into reducing mechanism and be ground into coarse powder, add 80% ethanol of medical material total weight parts 4 times amount, stir 10 minutes, be heated to 65 degrees Celsius, be incubated 4 hours, filtered while hot obtains filtrate, by filtrate fill spray bottle.
Embodiment 3
Prescription (weight portion):
Preparation method:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis is taken by above-mentioned weight ratio, put into reducing mechanism and be ground into coarse powder, add 70% ethanol of medical material total weight parts 4 times amount, stir 20 minutes, be heated to 70 degrees Celsius, be incubated 4 hours, filtered while hot obtains filtrate, by filtrate fill spray bottle.
Embodiment 4
Prescription (weight portion):
Preparation method:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis is taken by above-mentioned weight ratio, put into reducing mechanism and be ground into coarse powder, add 60% ethanol of medical material total weight parts 4 times amount, stir 10 minutes, be heated to 80 degrees Celsius, be incubated 3 hours, filtered while hot obtains filtrate, by filtrate fill spray bottle.
Embodiment 5
Prescription (weight portion):
Preparation method:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis is taken by above-mentioned weight ratio, put into reducing mechanism and be ground into coarse powder, add 70% ethanol of medical material total weight parts 4 times amount, stir 30 minutes, be heated to 75 degrees Celsius, be incubated 4 hours, filtered while hot obtains filtrate, by filtrate fill spray bottle.
The technology contents of the not detailed description of the present invention is known technology.
Claims (4)
1. clinical care is used for the treatment of a Chinese medicine composition for decubital ulcer, it is characterized in that, it is made up of following Chinese crude drug:
Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis.
2. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the Chinese crude drug of following weight proportioning:
3. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the Chinese crude drug of following weight proportioning:
4. the clinical care according to claim 1-3 is used for the treatment of the preparation method of the Chinese medicine composition of decubital ulcer, it is characterized in that, comprise following steps:
Take above-mentioned weight ratio Herba Euphorbiae Humifusae, Cortex Phellodendri, Radix Scutellariae, Cortex Moutan, Galla Chinensis, Olibanum, Myrrha, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi) and Radix Sophorae Flavescentis, put into reducing mechanism and be ground into coarse powder, add the 60%-80% ethanol of medical material total weight parts 4 times amount, stir 5-30 minute, be heated to 60-80 degree Celsius, insulation 2-8 hour, filtered while hot obtains filtrate, by filtrate fill spray bottle.Preferably, the alcohol concentration added is 70%-75%, and most preferably, the alcohol concentration added is 75%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870295A (en) * | 2021-03-22 | 2021-06-01 | 丽水市中心医院 | Traditional Chinese medicine granulation promoting powder and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870295A (en) * | 2021-03-22 | 2021-06-01 | 丽水市中心医院 | Traditional Chinese medicine granulation promoting powder and application thereof |
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