CN102357164B

CN102357164B - Medicine composition for clinical care of burns and preparation method thereof

Info

Publication number: CN102357164B
Application number: CN2011102578366A
Authority: CN
Inventors: 黄廷芬
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-09-02
Filing date: 2011-09-02
Publication date: 2013-02-20
Anticipated expiration: 2031-09-02
Also published as: CN102357164A

Abstract

The invention relates to a medicine composition for clinical care of burns and a preparation method thereof. The medicine composition is formed by the following raw materials by weight: 25 parts of mimosa pudica, 12 parts of lithospermum, 10 parts of polygonum cuspidatum, 10 parts of radix angelicae, 6 parts of gardenia, 35 parts of coptis chinensis, 30 parts of syzygium aromaticum, 15 parts of honeysuckle, 30 parts of scutellaria baicalensis, 30 parts of angelica sinensis, 12 parts of myrrh, 6 parts of rhizoma atractylodis, 10 parts of garden burnet, 12 parts of gallnut, 10 parts of pearl, 6 parts of smoked plum, 10 parts of calamine, 2 parts of pseudo-ginseng, 8 parts of gypsum rubrum, 5 parts of divaricate saposhnikovia roots, 10 parts of white backleaf mallotus roots, 6 parts of radix ampelopsis, 8 parts of frankincense and 10 parts of dragon's blood. The medicine composition for the clinical care of burns has low cost and remarkable curative effect, leaves no scars after curing and has broad application prospects.

Description

Pharmaceutical composition of a kind of clinical care of burns and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, more specifically, the present invention relates to pharmaceutical composition of a kind of clinical care of burns scalded patient and preparation method thereof.

Background technology

Burn, scald very commonly in people's daily life, burn is that body directly contacts high temp objects or is subject to the variation that strong heat radiation occurs, and is the tissue injury that is caused by high temperature, chemical substance or electricity.The degree of burn is by the height of temperature, the length of action time and difference, and local variation can be divided into four degree: the first degree: because of angioparalysis hyperemia; The second degree: form the burn vesicle that is full of serum; The 3rd degree: tissue necrosis; Fourth: the carbonization of tissue.Lactic acid production during burn in the visible blood increases, and the pH value of arteriovenous blood reduces, and blood capillary is handicapped to be increased the weight of along with organizing, and anoxemia is also serious.

The traditional Chinese medical science has deep theoretical basis about burn, and the traditional Chinese medical science thinks that burn also claims to burn skin ulcer, soup sprinkles baked wheaten cake, burn.Light shallow person does not affect viscera function usually, only blush occurs in the part, blisters, or rots; Severe one infringement area is large and dark, produces fire and contains impairment of YIN, and pyretic toxicity is very vehement, and consumption is hindered cloudy liquid in the body.Very then pyretic toxicity inside fire attack, or the General Symptoms such as QI and blood deficiency, clinical as seen thirsty, heating, constipation, even the dysuria agitation is not peaceful, unconsciousness and delirium.Treatment the lighter only needs external treatment, and with Radix Sanguisorbae, Radix Et Rhizoma Rhei equivalent, a little grinds into powder Borneolum Syntheticum, and Oleum sesami is transferred and applied.The suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of severe one, heat-clearing and toxic substances removing, Liang Ying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., or the solid and gas yin nourishing, recuperating depleted YANG and rescuing the patient from collapse, multiselect adds flavor with Rhizoma Coptidis toxic materials clearing away decoction, xijiao Dihuang Tang, Saigae Tataricae Ramulus Uncariae Cum Uncis soup or SHENGMAI SAN, shenfu decoction etc., if the course of disease is with the passing of time, the wasting QI-blood person then should benefiting qi and nourishing blood, available eight delicacies Tonga flavor.Outer treating method comprises the skin ulcer face that cleans, and blister is processed, and removes the items such as eschar or skin-grafting, also can be with above-mentioned ointment coating skin ulcer face, and severe patient should in time carry out Chinese and western medicine and rescue.

Western medicine burn mainly contains: 1. silver sulfadiazine (CF-100), and astriction is strong, can impel wound surface dry, but its shortcoming is to cause granulocytopenia; 2. first sulphur sky pus is applicable to suppurative wound surface, and to Gram-positive, gram negative bacteria has inhibitory action, its shortcoming: 1. topical application has the sense of calcination pain disease.2. the part patient has allergy.3. make the incrustation segregation lag, the course of disease prolongs, and suppresses the unfavorable wound healing of epithelial cell growth.3. gentamycin, broad-spectrum antiseptic, non-stimulated to wound surface, without pain, nursing is convenient, its shortcoming: long-term in a large number with after can cause renal dysfunction, Auditory nerve impairment easily produces drug resistance.

At present, the medication effect of most treatment empyrosis is not very good, the cycle that some drugs needs when the treatment empyrosis is longer, or still has the phenomenon of cicatrix after the treatment, or the dosage that need every day often, bring inconvenience to the patient, the medicine that is exactly in addition is when the treatment empyrosis, and the patient can not walk about outdoor, has limited patient's activity, or in medicine, add too much chemical constituent, patient's health is caused potential harm.

Summary of the invention

The present inventor in conjunction with secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, take external treatment with Chinese medicine as main, seek therapeutic regimen, adopt the pure natural herbal raw material, meticulously be mixed with the pharmaceutical composition of clinical care of burns of the present invention in conjunction with the Traditional Chinese Medicine technology, this Chinese medicine composition is not only short to empyrosis punishment more cycle, 1 degree is burnt or is scalded and can fully recover in 3 to 5 days, and 2 degree burns or scald can be fully recovered in 7-12 days, and 3 degree are burnt or scalded 15-25 and get final product, the patient only needs to change a 1-2 medicine in and gets final product, for the patient brings convenience, in addition, the said composition cure rate reaches 100%.

The present invention adopts following technical scheme to achieve these goals:

A kind of pharmaceutical composition of clinical care of burns is characterized in that it is that raw material by the following weight proportioning is made:

Herba Mimosae Pudicae 20-25 part, Radix Arnebiae (Radix Lithospermi) 12-15 part, Rhizoma Polygoni Cuspidati 10-25 part, Radix Angelicae Dahuricae 8-12 part,

Fructus Gardeniae 6-7 part, Rhizoma Coptidis 30-40 part, Flos Caryophylli 26-32 part, Flos Lonicerae 12-18 part,

Radix Scutellariae 28-32 part, Radix Angelicae Sinensis 26-32 part, Myrrha 12-18 part, Rhizoma Atractylodis 6-8 part,

Radix Sanguisorbae 8-12 part, Galla Chinensis 10-12 part, Margarita 10-12 part, Fructus Mume 5-8 part,

Calamina 10-12 part, Radix Notoginseng 1-3 part, Mirabilitum crystallina 8-12 part, Radix Saposhnikoviae 5-6 part,

Folium Malloti Apeltae 10-12 part, Radix Ampelopsis 4-6 part, Olibanum 8-12 part, Sanguis Draxonis 4-8 part.

The pharmaceutical composition of described clinical care of burns is characterized in that the weight portion of its constitutive material is preferably:

25 parts of Herba Mimosae Pudicaes, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts of the Radixs Angelicae Dahuricae,

6 parts of Fructus Gardeniaes, 35 parts of Rhizoma Coptidis, 30 parts of Flos Caryophyllis, 15 parts of Flos Loniceraes,

30 parts of Radix Scutellariaes, 30 parts of Radix Angelicae Sinensis, 12 parts of Myrrhas, 6 parts of Rhizoma Atractylodis,

10 parts of Radix Sanguisorbaes, 12 parts of Galla Chinensiss, 10 parts of Margaritas, 6 parts of Fructus Mumes,

10 parts of Calaminas, 2 parts of Radix Notoginseng, 8 parts of Mirabilitum crystallinas, 5 parts of Radix Saposhnikoviaes,

10 parts of Folium Malloti Apeltaes, 6 parts of Radix Ampelopsis, 8 parts of Olibanums, 10 parts of Sanguis Draxonis.

The side separates:

1 Herba Mimosae Pudicae; Nature and flavor: cold nature, sweet in the mouth, puckery; Slightly poisonous.Function cures mainly: the calmness of calming the nerves, eliminating stasis to stop pain, hemostasis convergence.Be used for neurasthenia, traumatic injury, spitting of blood, herpes zoster;

2, Radix Arnebiae (Radix Lithospermi): the property of medicine is sweet, salty, cold.GUIXIN, Liver Channel; Effect: clearing away heat,cooling blood and removing toxin rash;

3, Rhizoma Polygoni Cuspidati: the little hardship of the property of medicine is slightly cold.Return spleen, gallbladder, lung meridian; Effect: promoting the function of the gallbladder to alleviate jaundice, heat-clearing and toxic substances removing, eliminating stasis to stop pain, preventing phlegm from forming and stopping coughing;

4, the Radix Angelicae Dahuricae: the property of medicine is hot, warm.Return spleen, stomach, large intestine channel; Effect: detoxifcation cold expelling, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis;

5, Fructus Gardeniae: property of medicine bitter cold, GUIXIN, lung, tri-jiao channel; Effect: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body;

6, Rhizoma Coptidis: property of medicine bitter cold.GUIXIN, spleen, stomach, gallbladder, large intestine channel; Effect: heat clearing and damp drying, rush down large detoxifcation;

7, Flos Caryophylli: property is hot, temperature; Enter stomach, spleen, kidney channel, sending down the abnormal ascending QI, antifungal;

8, Flos Lonicerae: the property of medicine is sweet cold, returns lung, the heart, stomach warp; Effect: heat-clearing and toxic substances removing, dispelling wind and heat pathogens;

9, Radix Scutellariae: property of medicine bitter cold.Return lung, gallbladder spleen, stomach, large intestine small intestine meridian; Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis;

10, Radix Angelicae Sinensis: the property of medicine is sweet, hot, warm.Return liver, the heart, spleen channel; Effect: tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation;

11, Myrrha: property is bitter, flat, and loose blood goes to become silted up, reducing swelling and alleviating pain, granulation promoting, sterilization;

12, Rhizoma Atractylodis: the property of medicine is hot, bitter, warm, returns spleen, stomach, Liver Channel; Effect: drying damp and strengthening spleen, expelling wind and cold;

13, Radix Sanguisorbae: bitter, the acid, puckery of the property of medicine is slightly cold.Return liver, large intestine channel; Effect: cooling blood for hemostasis, detoxifcation sore;

14, Galla Chinensis: the property of medicine is sour, puckery, cold.Return lung, large intestine, kidney channel;

15, Margarita: nature and flavor are sweet, salty, cold, energy tranquilizing mind, removing toxic substances and promoting granulation;

16, Fructus Mume: property of medicine acid, puckery, flat.Return liver, spleen, lung, large intestine channel; Effect: astringing lung-QI and relieving cough, relieving diarrhea with astringents, relieving pain by calming ascaris, promoting the production of body fluid to quench thirst;

17, Calamina: the property of medicine is sweet flat, returns liver, stomach warp; Effect: detoxifcation improving acuity of vision and removing nebula, the antipruritic liana skin ulcer of removing dampness;

18, Radix Notoginseng: the sweet little hardship of property, temperature, nontoxic, hemostasis, loose silt, reducing swelling and alleviating pain, antiviral;

19, Mirabilitum crystallina: the property of medicine is hot, one-tenth, cold.GUIXIN, stomach kidney; Effect: clearing away heat-fire;

20, Radix Saposhnikoviae: hot, sweet, temperature.Return bladder, liver, spleen channel.Inducing diaphoresis to dispel wind wins and wets, relieving convulsion;

21, Folium Malloti Apeltae: cold, nontoxic.Heat clearing away, dampness removing, pain relieving, detoxifcation, hemostasis.Control stranguria with turbid discharge, stomachache, aphtha, hemorrhoid, ulcer, traumatic injury, venom, traumatic hemorrhage;

22, Radix Ampelopsis: property is bitter, hot, be slightly cold.GUIXIN, stomach warp; Effect: heat-clearing and toxic substances removing, expelling pus and promoting granulation, medicinal powder for relieving pain knot;

23, Olibanum: property suffering, hardship, sending down the abnormal ascending QI, antifungal;

24, Sanguis Draxonis: sweet, salty, the flat Liver Channel of returning of the property of medicine; Effect: the analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, expelling pus and promoting granulation;

Pharmaceutical composition its preparation method of the present invention is:

Example is taken various traditional Chinese medicine powders and is broken to 100-150 purpose fine powder in mass ratio, mixes and puts into the wide-mouth vial, and is for subsequent use.

The pharmaceutical composition of clinical care of burns of the present invention can be prepared into paste, and method is:

Example is taken various traditional Chinese medicine powders and is broken to 100-150 purpose fine powder in mass ratio, mixes and puts into the wide-mouth vial, and for subsequent use, then adding weight is the Oleum sesami of 4 times of raw material components weight, stirs and namely gets the paste product.

The patient when using medicine of the present invention, burn or scald broken skin no matter whether occurs, all without the gauze parcel, with wound with the disinfectant cleaning after, apply compositions of the present invention, changing dressings in one day gets final product for 1 time; The employing of broken skin ointment of the present invention or medicated powder do not spread upon the affected part, and scald or burn a few days ago also can be changed dressings 1-3 time in one day;

Compared with prior art, pharmaceutical composition of a kind of clinical care of burns provided by the invention and preparation method thereof has the following advantages:

1, using method is simple, does not need to be combined with other antibiotics the healing cycle short, instant effect, and preventing from scar;

The number of times of 2, changing dressings every day is few, brings a lot of convenience to the patient, and the patient can be freely movable at indoor or outdoors in therapeutic process;

3, the cure rate of 1 degree, 2 degree or 3 degree burns or scald all can reach 100%, even third degree burn, two weeks can be cured fully;

4, preparation method is simple, and cost is low, can carry out Produce on a large scale

5, after serious burn or the scald, do not need to arrange sterilizing room, do not need infrared ray radiation or skin-grafting, easy infection can not treated at common environment, does not have the requirement of gnotobasis, is applicable to all kinds of burns or scald.

The specific embodiment

Embodiment 1:

A kind of pharmaceutical composition of clinical care of burns, the weight portion of its constitutive material is:

Embodiment 2:

Example is taken various Chinese crude drugs and is crushed to respectively 100-150 purpose fine powder in mass ratio, mixes and puts into the wide-mouth vial, then gets the Oleum sesami of 4 times of above-mentioned Chinese medicine total amounts, adds the cream drug that stirs to get.

Embodiment 3:

1. this group patient 320 examples, wherein inpatient's 158 examples account for 49.4%, and outpatient's 162 examples account for 50.6%.The oldest 78 years old, minimum October.The average year tinkling of pieces of jade 36 years old.The burn common cause: (1) boiled water is scalded, (2) fire burn, and (3) thermal current blast injury, (4) chemical substance burn, such as sulphuric acid, lime water, (5) exhaustor is scalded.

Burned part: extremity 201 examples of burning account for 63%; Great part of face burns 87 examples account for 27%; Trunk 32 examples account for 10%.3. burn surface area and the degree of depth: I degree 86 examples of burning, maximum area accounts for whole body area 23.6%; Shallow II degree 105 examples of burning, maximum burn surface area 37%, deep ii degree burn 93 examples, maximum burn surface area 17%; III degree 36 examples of burning, maximum burn surface area 5%.

2. Therapeutic Method

For the fresh wound surface of firm burn, give after being admitted to hospital with povidone iodine or Povidone-Iodine Solution liquid disinfectant, and the dirt on the removing wound surface, there is the blister low level to break and emits hydrops, keep the bubble skin.Formation gives to steep skin and albumen freezes whole removings but albumen freezes.Downright bad beancurd sheet free or fold is removed, and sterilizes once after removing is clean again.Coating the present invention gets powder agent or the unguentum of the pharmaceutical composition of clinical care of burns, changes dressings once in 24 hours, changes dressings continuously 3 times, should give the wound surface debridement when changing dressings at every turn.

3. therapeutic outcome

This organizes 320 examples, I degree 86 examples of burning, all healed in 5 days.Shallow II degree 105 examples of burning, deep ii degree burn 93 examples, healing in 7～15 days.III degree 36 examples of burning, healing in 15～25 days.The II degree of being admitted to hospital in early days-III degree patient is through the debridement wrapping or expose treatment, does not occur affecting healing because of inflammatory reaction.The II degree of being admitted to hospital late period-III degree patient, because the part of burning occurs under the infected tissue liquefaction crust or empyema under the crust, though through thoroughly debridement, the local organization oxidation, but still inflammatory lesion impact healing appears.Though this group only has the patient of 2 routine III degree burns to climb living Regeneration and Repair and voluntarily healing through debridement circumferential edges skin, but still leaves the strip cicatrix.Clinically visit 1～3 year 173 example and account for 54%, do not have other discomforts.

Embodiment 4

Following for adopting the some patients were treatment situation behind the pharmaceutical composition of the present invention

At poplar 31 years old age of woman, shank and thigh place are scalded by boiled water, and the scald place is red and swollen, bubble, burn surface area reaches 10%, behind the coating present composition powder formulation, and afterwards recovery from illness in 3 days, and scald place preventing from scar, the patient does not have pain in the process of the drug of topical application, cure rate reaches 100%;

At 24 years old age of Liu man, step is burnt, and belongs to serious burn, and burn surface area reaches 35%, apply pharmaceutical composition ointment preparation of the present invention after, rear preventing from scar is cured in afterwards recovery from illness in 12 days;

At 60 years old age of Wang woman, the arm place is burnt, and burn surface area reaches 25%, the broken skin phenomenon occurs, apply compositions medicated powder of the present invention after, recovery from illness in 7 days, affected part preventing from scar after curing, cure rate reaches 100%;

At Lee's 22 years old age of man, the shank burn is serious, changes treatment over to from other hospital, rots in the affected part, it is uncontrollable to be in a bad way, and patient's pain can't bear, and wound deterioration infects, rear employing combination treatment of the present invention after 7 days the state of an illness greatly take a turn for the better, afterwards recovery from illness in 25 days is not stayed scar after more.

Above-mentioned each Chinese medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative effect of curing the disease, having drug effect between each composition of used raw material of Chinese medicine is interweaved and mutually promotes and coordinate usefulness, through clinical verification, can be used in various degree burn, scald, in the medical practice in nearly ten years of the applicant, the case number of curing is numerous, all obtain good effect, and with low cost, alleviate patient's burden.

The pharmaceutical composition of the application's clinical care of burns is with low cost, and is evident in efficacy, and preventing from scar after the treatment has broad application prospects.

Claims

1. the pharmaceutical composition of a clinical care of burns is characterized in that, the weight portion of its constitutive material is:

2. the pharmaceutical composition of clinical care of burns claimed in claim 1 is preparing the purposes for the treatment of in the burn and scald medicine.