CN105311370A - Preparation for treating electric burn and preparation process of preparation for treating electric burn - Google Patents
Preparation for treating electric burn and preparation process of preparation for treating electric burn Download PDFInfo
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- CN105311370A CN105311370A CN201510322738.4A CN201510322738A CN105311370A CN 105311370 A CN105311370 A CN 105311370A CN 201510322738 A CN201510322738 A CN 201510322738A CN 105311370 A CN105311370 A CN 105311370A
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Abstract
The invention relates to a preparation for treating electric burn and a preparation process of the preparation for treating electric burn. The preparation is mainly prepared from rhizoma polygoni cuspidati, radix sanguisorbae, dragon's blood, radix notoginseng, herba euphorbiae humifusae, radix angelicae sinensis, crocus sativus, radix paeoniae rubra, olibanum, rhizoma ligustici wallichii, fructus forsythiae, rhizoma rehmanniae, radix ophiopogonis, radix zanthoxyli, rhizoma atractylodis, fructus gardeniae, herba patriniae, honeysuckle, folium perillae, radix isatidis, fructus chaenomelis lagenariae and rhizoma corydalis. Active medicinal ingredients are extracted for preparing powder. The preparation for treating electric burn is remarkable in electric burn treatment effect and has a promising application prospect.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, concrete, relate to a kind of preparation for electric burn and preparation technology thereof.
Background technology
Electric burn refers to that electric current produces by human body the extensive injuries that pyroelectric effect, electro physiology effect, electrochemical effect and electric arc, electric spark etc. cause human body and skin, subcutaneous tissue, muscle and deep, blood vessel, nerve, osteoarthrosis and internal viscera.Degree is by the height of temperature, the length of action time and different, and the change of local can be divided into four degree: first degree: the hyperemia because of angioparalysis; Second degree: form the burn vesicle being full of serum; 3rd degree: tissue necrosis; Fourth: the carbonization of tissue.Lactic acid production during burn in visible blood increases, and the pH value of arteriovenous blood reduces, and along with organizing, blood capillary is handicapped to be increased the weight of, and anoxemia is also serious.The gas of severe patient infringement pyretic toxicity burns very, injures body meat muscles and bones, or pyretic toxicity inside fire attack internal organs, so that internal organs discord, skin and flesh rot; The clinical manifestation of the wounded mainly contains that tired behaviour is peaceful, unconsciousness and delirium, shortened and contracted tongue and rolling up, the hot tongue spinosity of loathing of cold shape, and urine twinge is not well, is pyretic toxicity telepathy; And for example roughly to pant, cough blood of spitting, expectorant is sticky smooth, gurgling with sputum, flaring of nares, urine inaccessible obstructed is that pyretic toxicity passes lung; Altering direct-view or spasm jaundice for another head tremor order, is that pyretic toxicity passes liver; For another example abdominal distention constipation, it is frequently many that smelly, number of times is glued in loose stool, and nausea and vomiting is pyretic toxicity transmitting into the spleen; That pyretic toxicity passes kidney if see urine retention, hematuria, edema, pant.
Domestic mostly employing is at present cut crust or is cut the method for crust skin-grafting, but the method clinical requirement condition is higher, and expense is comparatively large, and basic hospital is difficult to be competent at.Superficial burns is as improper in early stage Wound treatment, now can occur creating all inflammation.Serious burn is due to the strike of experience shock, and general immunity function state at a low ebb, very high to the susceptibility of pathogen, the probability of early stage outburst systemic infection is also high, and the threat of infection will last till the healing of wound surface.
Motherland's traditional medicine has deep theoretical basis about calcination wound, and the traditional Chinese medical science thinks that burn sprinkles baked wheaten cake, burn also known as baked wheaten cake skin ulcer, soup.Light shallow person does not affect viscera function usually, only occurs blush in local, blisters, or rots; Severe one infringement area is large and deeply, produce fire and contain impairment of YIN, and pyretic toxicity is very vehement, and consumption hinders cloudy liquid in body.Very then pyretic toxicity inside fire attack, or the General Symptoms such as QI and blood deficiency, clinical thirsty as seen, heating, constipation, even dysuria agitation is peaceful, unconsciousness and delirium.Treatment the lighter only needs external treatment, and by Radix Sanguisorbae, Radix Et Rhizoma Rhei equivalent, Borneolum Syntheticum is ground into powder a little, and Oleum sesami dresses.The suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of severe one, heat-clearing and toxic substances removing, Liang Ying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., or solid and gas yin nourishing, recuperating depleted YANG and rescuing the patient from collapse, multiselect Rhizoma Coptidis toxic materials clearing away decoction, xijiao Dihuang Tang, Saigae Tataricae Ramulus Uncariae Cum Uncis soup or SHENGMAI SAN, shenfu decoction etc. add taste, if the course of disease is with the passing of time, wasting QI-blood person, then suitable benefiting qi and nourishing blood, available eight delicacies Tonga taste.Outer treating method comprises cleaning skin ulcer face, and the item such as eschar or skin-grafting is removed in blister process, also can by above-mentioned ointment coating skin ulcer face.
At present, the medication effect of most treatment burn is not very good, some drugs treatment cycle is longer, or the dosage that every day needs often, bring inconvenience to patient, the medicine patient being exactly in addition can not walk about in outdoor, limits the activity of patient, or in medicine, add too much chemical composition, potential harm is caused to the health of patient.
Summary of the invention
The object of the present invention is to provide a kind of preparation and the preparation technology thereof that treat electric burn, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core theory of Chinese medicine disease always, how to take into account secondary pathogenesis for main pathogenesis medication simultaneously, take into account the treatment of general character and individual character, thus at utmost embody intension and the extension of Chinese traditional treatment disease, be a realistic problem of Chinese patent medicine compatibility.The present invention, based on external treatment with Chinese medicine, seeks therapeutic regimen, adopts pure natural Chinese herbal medicine raw material, the preparation for electric burn of the present invention is meticulously mixed with in conjunction with Traditional Chinese Medicine technology, said preparation is not only short to the electric burn healing cycle, and for patient brings convenience, cure rate also significantly improves.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
For a preparation for electric burn, it is characterized in that it is made by following raw material:
Rhizoma Polygoni Cuspidati, Radix Sanguisorbae, Sanguis Draxonis, Radix Notoginseng, Herba Euphorbiae Humifusae, Radix Angelicae Sinensis, Stigma Croci, Radix Paeoniae Rubra, Olibanum, Rhizoma Chuanxiong, Fructus Forsythiae, Radix Rehmanniae, Radix Ophiopogonis, Radix Zanthoxyli, Rhizoma Atractylodis, Fructus Gardeniae, Herba Patriniae, Flos Lonicerae, Folium Perillae, Radix Isatidis, Fructus Chaenomelis, Rhizoma Corydalis.
Preferably, described preparation is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 50 parts, Radix Sanguisorbae 50 parts, Sanguis Draxonis 45 parts, Radix Notoginseng 40 parts, Herba Euphorbiae Humifusae 40 parts, Radix Angelicae Sinensis 40 parts, Stigma Croci 35 parts, Radix Paeoniae Rubra 35 parts, Olibanum 35 parts, Rhizoma Chuanxiong 30 parts, Fructus Forsythiae 30 parts, Radix Rehmanniae 30 parts, Radix Ophiopogonis 25 parts, Radix Zanthoxyli 25 parts, Rhizoma Atractylodis 25 parts, Fructus Gardeniae 20 parts, Herba Patriniae 20 parts, Flos Lonicerae 20 parts, Folium Perillae 18 parts, Radix Isatidis 18 parts, Fructus Chaenomelis 18 parts, Rhizoma Corydalis 15 parts.
The preparation method of described preparation is: take each crude drug according to above-mentioned parts by weight;
(1) get Herba Euphorbiae Humifusae, Stigma Croci, Radix Ophiopogonis, Herba Patriniae, Folium Perillae, Rhizoma Corydalis mix in described ratio, add the ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;
(2) get surplus stock medicine and add 4 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merges twice filtrate, and it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, after 80 DEG C of oven dry, is ground into powder, is complex B;
(4) Homogeneous phase mixing complex A and complex B, obtains powder.
Patient, when using medicine of the present invention, after being cleared up by wound use water, applies compositions of the present invention, within one day, changes dressings 1 time; The employing of broken skin powder of the present invention does not spread upon affected part, bandages.Initial two days that burn, within one day, also can change dressings 3 times.The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, and bring out the best in each other, mild in medicine property and, it possesses following effect:
1) minimizing is oozed out, protection wound surface, wound healing, and after healing, cicatrix is few;
2) using method is simple, and the number of times of changing dressings every day is few, brings a lot of convenience to patient, and does not need short in conjunction with the healing cycle with other antibiotics, instant effect;
3) can treat at common environment, not have the requirement of gnotobasis, preparation method is simple, and cost is low, can carry out Produce on a large scale.There is not toxic and side effects, have a extensive future.
Detailed description of the invention
Embodiment 1
For a preparation for electric burn, it is characterized in that described preparation is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 50 parts, Radix Sanguisorbae 50 parts, Sanguis Draxonis 45 parts, Radix Notoginseng 40 parts, Herba Euphorbiae Humifusae 40 parts, Radix Angelicae Sinensis 40 parts, Stigma Croci 35 parts, Radix Paeoniae Rubra 35 parts, Olibanum 35 parts, Rhizoma Chuanxiong 30 parts, Fructus Forsythiae 30 parts, Radix Rehmanniae 30 parts, Radix Ophiopogonis 25 parts, Radix Zanthoxyli 25 parts, Rhizoma Atractylodis 25 parts, Fructus Gardeniae 20 parts, Herba Patriniae 20 parts, Flos Lonicerae 20 parts, Folium Perillae 18 parts, Radix Isatidis 18 parts, Fructus Chaenomelis 18 parts, Rhizoma Corydalis 15 parts.
The preparation method of described preparation is: take each crude drug according to above-mentioned parts by weight
(1) get Herba Euphorbiae Humifusae, Stigma Croci, Radix Ophiopogonis, Herba Patriniae, Folium Perillae, Rhizoma Corydalis mix in described ratio, add the ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, be ground into powder, be complex A;
(2) get surplus stock medicine and add 4 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merges twice filtrate, and it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, after 80 DEG C of oven dry, is ground into powder, is complex B;
(3) Homogeneous phase mixing complex A and complex B, obtains powder.
After wound use water is cleared up, apply compositions of the present invention, within one day, change dressings 1 time; The employing of broken skin powder of the present invention does not spread upon affected part, bandages.Initial two days that burn, within one day, also can change dressings 3 times.
Embodiment 2
Experiment of Zoology
Pharmacology pharmacodynamic is tested
One, local application of the present invention toxicology
The acute toxicity test of research rat damaged skin surface administration
Rat skin toxicity test Cmax (30 times of pharmacodynamics optium concentration) is administered once.To observation post administration 7 days, and matched group compared, and tested group of rat does not only occur death but also do not occur obvious toxic reaction.Illustrate that invention formulation is extremely low through damaged skin surface administration toxicity.
Rabbit Skin Irritation Test
Muptiple-use (continuous coating 7 days) irritant test is carried out, by " new drug (Western medicine) preclinical study guideline compilation (pharmacy, pharmacology, toxicology) " scoring with New Zealand white rabbit intact skin and damaged skin.Result shows: after multiple dosing terminates, and at check plot and tested district comparative observation, the equal < of skin wound repair intensity 0.5 point, does not observe the irritant reaction such as skin erythema, edema during multiple dosing yet.Show that invention formulation multiple dosing (7 days) is to rabbit intact skin and the equal nonirritant of damaged skin.
Embodiment 3
Clinical case
This test data have recorded 87 routine electric burn patient test of cure and follows the tracks of return visit situation.
Test group data: this group patient is totally 87 examples, man 53 example, female 34 example, patient age is between 21 years old-50 years old, and burn gross area 1%-40%.Wound surface reach dark II degree be 23%, light degree Ⅱ is 45%, I degree of burn and scald is 32%.Traumatogenic reason is the burns such as hydrothermal solution, flame, electricity.
Therapeutic Method: for fresh wound surface, gives with povidone iodine or Povidone-Iodine Solution liquid disinfectant, and removes the dirt on wound surface, have blister low level to break releasing hydrops, retains bubble skin.Downright bad beancurd sheet that is free or fold is removed, and removes totally and sterilizes once again.Coating preparation, Direct Uniform is applied to wound surface, can wrap up or not wrap up, if wound is dirtier, the drug of topical application after available clean water wound surface; General patient only needs medication every day once, serious symptom person can change dressings every day three times or wound surface dry after coating again.
This group 87 example, I degree burn 28 example, all healed in 5 days.Shallow II degree burn 39 example, deep ii degree burn 20 example, healing in 7 ~ 14 days.Repair and self-heal though this group only has the epithelium of patient through wound surface edge of 2 routine deep ii degree burns to climb life, but still leave strip cicatrix, do not have other uncomfortable.
Model case
Case 1, Zhao, man, 41 years old, electric spark was burnt right shoulder, wound is red and swollen, bubbles, affected part area 4 × 9cm, after coating present composition powder formulation, fully recover after 4 days, and scald place preventing from scar, patient, in the process of the drug of topical application, does not have pain and other sense of discomfort.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (3)
1. for a preparation for electric burn, it is characterized in that, described preparation is prepared from by the raw material of following weight parts:
Rhizoma Polygoni Cuspidati 50 parts, Radix Sanguisorbae 50 parts, Sanguis Draxonis 45 parts, Radix Notoginseng 40 parts, Herba Euphorbiae Humifusae 40 parts, Radix Angelicae Sinensis 40 parts, Stigma Croci 35 parts, Radix Paeoniae Rubra 35 parts, Olibanum 35 parts, Rhizoma Chuanxiong 30 parts, Fructus Forsythiae 30 parts, Radix Rehmanniae 30 parts, Radix Ophiopogonis 25 parts, Radix Zanthoxyli 25 parts, Rhizoma Atractylodis 25 parts, Fructus Gardeniae 20 parts, Herba Patriniae 20 parts, Flos Lonicerae 20 parts, Folium Perillae 18 parts, Radix Isatidis 18 parts, Fructus Chaenomelis 18 parts, Rhizoma Corydalis 15 parts.
2. preparation according to claim 1, is characterized in that, the preparation method of described preparation comprises the steps:
1) each raw material for standby is taken according to weight portion;
2) get Herba Euphorbiae Humifusae, Stigma Croci, Radix Ophiopogonis, Herba Patriniae, Folium Perillae, Rhizoma Corydalis, mixing, adds the ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, are ground into powder, are complex A;
3) get surplus stock, mixing, add 4 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merges twice filtrate, and it is the extractum of 1.2g/ml that filtrate decompression drying is obtained density, after 80 DEG C of oven dry, is ground into powder, is complex B;
4) by complex A and complex B mix homogeneously, to obtain final product.
3. preparation described in claim 1-2 is used for the purposes of electric burn.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510322738.4A CN105311370A (en) | 2015-06-14 | 2015-06-14 | Preparation for treating electric burn and preparation process of preparation for treating electric burn |
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| CN201510322738.4A CN105311370A (en) | 2015-06-14 | 2015-06-14 | Preparation for treating electric burn and preparation process of preparation for treating electric burn |
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| CN105311370A true CN105311370A (en) | 2016-02-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770436A (en) * | 2016-03-18 | 2016-07-20 | 杭州富阳飞博科技有限公司 | Ointment for burns and scalds |
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| CN101249247A (en) * | 2008-03-21 | 2008-08-27 | 贾桂英 | Chinese medicine ointment preparation for curing shallow second-degree burn |
| CN102688360A (en) * | 2012-06-20 | 2012-09-26 | 解阳阳 | Externally-applied skin medicine for treating burn and scald |
| KR101325608B1 (en) * | 2011-05-13 | 2013-11-06 | 김일광 | Compositions for burn treatment, and producing method of the same |
| CN104352944A (en) * | 2014-12-07 | 2015-02-18 | 黄勇 | Pharmaceutical composition for acnes |
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2015
- 2015-06-14 CN CN201510322738.4A patent/CN105311370A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249247A (en) * | 2008-03-21 | 2008-08-27 | 贾桂英 | Chinese medicine ointment preparation for curing shallow second-degree burn |
| KR101325608B1 (en) * | 2011-05-13 | 2013-11-06 | 김일광 | Compositions for burn treatment, and producing method of the same |
| CN102688360A (en) * | 2012-06-20 | 2012-09-26 | 解阳阳 | Externally-applied skin medicine for treating burn and scald |
| CN104352944A (en) * | 2014-12-07 | 2015-02-18 | 黄勇 | Pharmaceutical composition for acnes |
Non-Patent Citations (1)
| Title |
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| 葛欣: "中医疗法在烧伤治疗中的应用", 《辽宁医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770436A (en) * | 2016-03-18 | 2016-07-20 | 杭州富阳飞博科技有限公司 | Ointment for burns and scalds |
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Application publication date: 20160210 |