CN105770436A - Ointment for burns and scalds - Google Patents
Ointment for burns and scalds Download PDFInfo
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- CN105770436A CN105770436A CN201610154693.9A CN201610154693A CN105770436A CN 105770436 A CN105770436 A CN 105770436A CN 201610154693 A CN201610154693 A CN 201610154693A CN 105770436 A CN105770436 A CN 105770436A
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- herba
- radix
- rhizoma
- ointment
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/13—Coniferophyta (gymnosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention relates to an ointment for burns and scalds, made from the medicinal materials: Rhizoma Polygoni Cuspidati, Radix Arnebiae seu Lithospermi, Poria, Stigma Croci Sattvi, Galla Chinensis, Radix Glycyrrhizae, Herba Violae, Fructus Forsythiae, Herba Patriniae, Herba Houttuyniae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Hedyotis Diffusae, Pseudobulbus Cremastrae seu Pleiones, Rhizoma Paridis, Cacumen Platycladi, Fructus Gardeniae, Radix Angelicae Dahuricae, Cortex Phellodendri, Herba Artemisiae Anomalae, Rhizoma Bletillae, Folium Artemisiae Argyi, Cortex Moutan Radicis, Radix Paeoniae Rubra, Rhizoma Rehmanniae Preparata, Radix Notoginseng, Rhizoma Atractylodis Macrocephalae, Flos Carthami, Rhizoma Chuanxiong, Semen Vaccariae, Herba Lycopodii, and Fructus Tribuli. The ointment is prepared by pulverizing and screening effective medicinal ingredients. The ointment is effective in clearing heat and drying dampness, subsiding swelling and relieving pain, and activating blood and dredging channels, has significant effect for treating burns and scalds and has a promising application prospect.
Description
Technical field
The invention belongs to Chinese medicine technical field, concrete, relate to a kind of ointment for empyrosis.
Background technology
Empyrosis is the common accident trauma that a kind of serious harm people are healthy, and burn or the degree scalded are different, and the weight caused injury differs, light injured skin, the muscle injury of weight, heavier damage muscles and bones.No matter the burn and scald of weight, itself is all fire-toxin or pyretic toxicity, hinders face and infects as malpractice causes and maybe can compel poison inside fire attack, even can develop into septicemia, pyaemia septica or tetanus.Empyrosis is always the difficult and complicated illness being difficult to treat, and the degree of burn is different by the height of temperature, the length of action time, and the change of local can be divided into four degree: first degree: congested because of angioparalysis;Second degree: form the burn vesicle being full of serum;3rd degree: tissue necrosis;Fourth: the carbonization of tissue.During burn, the lactic acid production in visible blood increases, and the pH value of arteriovenous blood reduces, and along with organizing, blood capillary is handicapped to be increased the weight of, and anoxemia is also serious.
The method of whether traditional or modern traditional Chinese medical herbal treatment burn or prescription, generally all rest on the secret recipe stage, do not form practical pharmaceutical products, it is easy to make traditional secret recipe lost and make the treasure of our Traditional Chinese Medicine run off, the present inventor is for above-mentioned situation, the mechanism of traditional Chinese medical herbal treatment of concentrating on studies burn.The traditional Chinese medical science has deep theoretical basis about burn, and the traditional Chinese medical science thinks that burn is also known as burning skin ulcer, the bold and vigorous baked wheaten cake of soup, burn.Light shallow person does not generally affect viscera function, only blush occurs in local, blisters, or rots;Severe one infringement area is deep greatly, produces fire and contains impairment of YIN, and pyretic toxicity is vehement very, consumes the internal cloudy liquid of wound.Very then pyretic toxicity inside fire attack, or the General Symptoms such as QI and blood deficiency, clinic is thirsty as seen, heating, constipation, even dysuria agitation is peaceful, unconsciousness and delirium.Treatment the lighter only needs external treatment, and by Radix Sanguisorbae, Radix Et Rhizoma Rhei equivalent, Borneolum Syntheticum is ground into powder a little, and Oleum sesami dresses.The suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of severe one, heat-clearing and toxic substances removing, Liang Ying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., or solid and gas yin nourishing, recuperating depleted YANG and rescuing the patient from collapse, selects Rhizoma Coptidis toxic materials clearing away decoction, xijiao Dihuang Tang, Saigae Tataricae Ramulus Uncariae Cum Uncis soup or SHENGMAI SAN, shenfu decoction etc. to add taste, if the course of disease is with the passing of time more, wasting QI-blood person, then suitable benefiting qi and nourishing blood, available eight delicacies Tonga taste.Outer treating method includes cleaning skin ulcer face, and blister processes, and removes the item such as eschar or skin-grafting, also above-mentioned ointment can be applied skin ulcer face, and severe patient should carry out Chinese and western medicine rescue in time.
Currently for the treatment of empyrosis, it is generally adopted doctor trained in Western medicine or application compress, but they often do not have the function of antiinflammatory, and it is poor with the antiphlogistic antibacterial adaptability of Western medicine, easily cause the internal phenomenon remaining in inflammation of surface healing, cause the wound obstinate of patient, bad during fashion.In conventional epiderm skin burn therapeutic process, the cycle of curing is very long, and medication process patient is very painful, and easy scar, affects attractive in appearance.
The medication effect of most treatment empyrosis is not very good, some drugs treatment cycle is longer, or the dosage that every day needs is often, inconvenience is brought to patient, the medicine patient being exactly additionally can not walk about in outdoor, limit the activity of patient, or in medicine, add too much chemical composition, the health of patient is caused potentially hazardous.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating burn and scald and preparation method thereof, present inventor in conjunction with secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, based on external treatment with Chinese medicine, seek therapeutic regimen, adopt pure natural Chinese herbal medicine raw material, the pharmaceutical composition of the treatment burn of the present invention meticulously it is configured in conjunction with Traditional Chinese Medicine technology, it is short that empyrosis place is not only cured the cycle by this Chinese medicine composition, bring convenience for patient, additionally, said composition cure rate is high, have no side effect.
For realizing the object of the invention, the technical solution used in the present invention is as follows:
A kind of ointment for empyrosis, it is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 20-25 part, Radix Arnebiae (Radix Lithospermi) 20-25 part, Poria 20-25 part, Stigma Croci 20-25 part, Galla Chinensis 20-22 part,
Radix Glycyrrhizae 20-22 part, Herba Violae 18-20 part, Fructus Forsythiae 18-20 part, Herba Patriniae 18-20 part, Herba Houttuyniae 18-20 part,
Herba Scutellariae Barbatae 15-18 part, Herba Taraxaci 15-18 part, Herba Hedyotidis Diffusae 15-18 part, Pseudobulbus Cremastrae Seu Pleiones 15-18 part, Rhizoma Paridis 15-18 part,
Cacumen Platycladi 12-15 part, Fructus Gardeniae 12-15 part, Radix Angelicae Dahuricae 12-15 part, Cortex Phellodendri 12-15 part, Herba Artemisiae Anomalae 12-15 part,
Pseudobulbus Bletillae (Rhizoma Bletillae) 10-12 part, Folium Artemisiae Argyi 10-12 part, Cortex Moutan 10-12 part, Radix Paeoniae Rubra 10-12 part, Radix Rehmanniae Preparata 10-12 part,
Radix Notoginseng 5-8 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Flos Carthami 5-8 part, Rhizoma Chuanxiong 5-8 part, Semen Vaccariae 5-8 part,
Lycopodium casuarinoides Spring 3-5 part, Fructus Tribuli 3-5 part.
The preparation method of described ointment is: weigh each crude drug according to above-mentioned parts by weight
(1) take tiger account, Stigma Croci, Herba Patriniae, Herba Houttuyniae, Herba Scutellariae Barbatae, Cacumen Platycladi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Rhizoma Chuanxiong mix in described ratio, add the ethanol relative to 2 times of weight 95% of mixture, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of drying, it is ground into powder, is complex A;
(2) taking surplus stock medicine and add 5 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merge twice filtrate, it is the extractum of 1.2g/ml that filtrate decompression dries acquisition density, after 80 DEG C of drying, is ground into powder, is complex B;
(3) Homogeneous phase mixing complex A and complex B obtains medicated powder, is stirred evenly by weight 1:1.5 mix with Oleum Sesami by medicated powder, after infrared lamp sterilizing, loads interior sealing of sterile vessel and preserves.Used time ointment of getting it filled is applied to through cleaning or hindering on face of sterilizing.
Points for attention: avoid the food of edible pungent stimulation and photosensitivity during treatment, such as Fructus Capsici, beef or mutton, fish and shrimp, seafood, Herba Apii graveolentis, Herba Coriandri, white turnip, Fructus Mangifera Indicae, soy sauce, drinks etc., it is to avoid cause inflammation infection, pigmentation and promote scar hyperplasia.Want many edible vegetables and digestible food, with QI and blood deficiency in complement and having additional nutrients, control and prevention is infected, the nutrition such as activated protein, micro-element and immunity in reinforcement.To improve health and the healing of skin function acceleration callus, skin is conducive to recover normal as early as possible, it is prevented that wound cicatrix.And in combinations with taking vitamin C, vitamin E, each 100 milligrams every time.Three times on the one, it is possible to reduce because of the calmness of pigment in the treatment wound processes such as medicine (external is taken orally), promote rehabilitation.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and it prepares simplicity, and medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and all medicines share, and bring out the best in each other, mild in medicine property and, it possesses following effect:
1) minimizing is oozed out, and protects wound surface, and wound healing, after healing, cicatrix is few;
2) using method is simple, and the number of times changed dressings every day is few, brings a lot of convenience to patient, and need not be short in conjunction with the healing cycle with other antibiotics, instant effect;
3) can treating at common environment, it does not have the requirement of gnotobasis, preparation method is simple, and cost is low, it is possible to carry out Produce on a large scale.Toxic and side effects does not occur, has a extensive future.
Detailed description of the invention
Embodiment 1
A kind of ointment for empyrosis, it is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 20 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, 20 parts of Poria, Stigma Croci 20 parts, Galla Chinensis 20 parts,
20 parts of Radix Glycyrrhizae, Herba Violae 18 parts, Fructus Forsythiae 18 parts, Herba Patriniae 18 parts, Herba Houttuyniae 18 parts,
Herba Scutellariae Barbatae 15 parts, Herba Taraxaci 15 parts, Herba Hedyotidis Diffusae 15 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Rhizoma Paridis 15 parts,
Cacumen Platycladi 12 parts, Fructus Gardeniae 12 parts, the Radix Angelicae Dahuricae 12 parts, Cortex Phellodendri 12 parts, Herba Artemisiae Anomalae 12 parts,
The Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Folium Artemisiae Argyi 10 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 10 parts, 10 parts of Radix Rehmanniae Preparata,
Radix Notoginseng 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts of Flos Carthami, Rhizoma Chuanxiong 5 parts, Semen Vaccariae 5 parts,
Lycopodium casuarinoides Spring 3 parts, Fructus Tribuli 3 parts.
The preparation method of described ointment is: weigh each crude drug according to above-mentioned parts by weight
(1) take tiger account, Stigma Croci, Herba Patriniae, Herba Houttuyniae, Herba Scutellariae Barbatae, Cacumen Platycladi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Rhizoma Chuanxiong mix in described ratio, add the ethanol relative to 2 times of weight 95% of mixture, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of drying, it is ground into powder, is complex A;
(2) taking surplus stock medicine and add 5 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merge twice filtrate, it is the extractum of 1.2g/ml that filtrate decompression dries acquisition density, after 80 DEG C of drying, is ground into powder, is complex B;
(3) Homogeneous phase mixing complex A and complex B obtains medicated powder, is stirred evenly by weight 1:1.5 mix with Oleum Sesami by medicated powder, after infrared lamp sterilizing, loads interior sealing of sterile vessel and preserves.Used time ointment of getting it filled is applied to through cleaning or hindering on face of sterilizing.
Embodiment 2
A kind of ointment for empyrosis, it is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 25 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, 25 parts of Poria, Stigma Croci 25 parts, Galla Chinensis 22 parts,
22 parts of Radix Glycyrrhizae, Herba Violae 20 parts, Fructus Forsythiae 20 parts, Herba Patriniae 20 parts, Herba Houttuyniae 20 parts,
Herba Scutellariae Barbatae 18 parts, Herba Taraxaci 18 parts, Herba Hedyotidis Diffusae 18 parts, Pseudobulbus Cremastrae Seu Pleiones 18 parts, Rhizoma Paridis 18 parts,
Cacumen Platycladi 15 parts, Fructus Gardeniae 15 parts, the Radix Angelicae Dahuricae 15 parts, Cortex Phellodendri 15 parts, Herba Artemisiae Anomalae 15 parts,
The Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, Folium Artemisiae Argyi 12 parts, Cortex Moutan 12 parts, Radix Paeoniae Rubra 12 parts, 12 parts of Radix Rehmanniae Preparata,
Radix Notoginseng 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, 8 parts of Flos Carthami, Rhizoma Chuanxiong 8 parts, Semen Vaccariae 8 parts,
Lycopodium casuarinoides Spring 5 parts, Fructus Tribuli 5 parts.
The preparation method of described ointment is: weigh each crude drug according to above-mentioned parts by weight
(1) take tiger account, Stigma Croci, Herba Patriniae, Herba Houttuyniae, Herba Scutellariae Barbatae, Cacumen Platycladi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Rhizoma Chuanxiong mix in described ratio, add the ethanol relative to 2 times of weight 95% of mixture, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of drying, it is ground into powder, is complex A;
(2) taking surplus stock medicine and add 5 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merge twice filtrate, it is the extractum of 1.2g/ml that filtrate decompression dries acquisition density, after 80 DEG C of drying, is ground into powder, is complex B;
(3) Homogeneous phase mixing complex A and complex B obtains medicated powder, is stirred evenly by weight 1:1.5 mix with Oleum Sesami by medicated powder, after infrared lamp sterilizing, loads interior sealing of sterile vessel and preserves.Used time ointment of getting it filled is applied to through cleaning or hindering on face of sterilizing.
Embodiment 3
Experiment of Zoology
Pharmacology pharmacodynamic is tested
One, local application of the present invention toxicology
The acute toxicity test of research rat damaged skin surface administration
Rat skin toxicity test Cmax (30 times of pharmacodynamics optium concentration) is administered once.To observation post administration 7 days, and matched group compared, and tested group of rat not only death does not occur but also obvious toxic reaction do not occur.Illustrate that invention formulation is extremely low through damaged skin surface administration toxicity.
Rabbit Skin Irritation Test
Muptiple-use (continuous coating 7 days) irritant test is carried out, by " new drug (Western medicine) preclinical study guideline compilation (pharmacy, pharmacology, toxicology) " scoring with New Zealand white rabbit intact skin and damaged skin.Result shows: after multiple dosing terminates, and at check plot and tested district comparative observation, the equal < of skin wound repair intensity 0.5 point, does not also observe the irritant reaction such as skin erythema, edema during multiple dosing.Show that ointment multiple dosing of the present invention (7 days) is to the equal nonirritant of rabbit intact skin and damaged skin.
Embodiment 4
Clinical case
1. this group patient 133 example, wherein inpatient 78 example accounts for 58.6%, and outpatient 55 example accounts for 41.4%.The oldest 61 years old, minimum 12 years old.Burn common cause: (1) boiled water is scalded, (2) fire burn, (3) thermal current blast injury, (4) chemical substance is burnt, such as sulphuric acid, lime water, (5) Colophonium scald etc..
Diagnosis proves: burned part, and extremity 77 examples of burning account for 57.9%;Great part of face burns 29 example accounts for 21.8%;Trunk 27 example accounts for 20.3%.
Burn surface area and the degree of depth: I degree is burnt 53 examples, and maximum area accounts for whole body area 21.3%;Shallow II degree is burnt 44 examples, deep ii degree burn 23 example;III degree is burnt 13 examples.
2. Therapeutic Method
For the fresh wound surface just burnt, give with povidone iodine or Povidone-Iodine Solution liquid disinfectant after being admitted to hospital, and remove the dirt on wound surface, have blister low level to break releasing hydrops, retain bubble skin.Free or fold downright bad beancurd sheet is removed, and removes after totally and sterilizes once again.The coating present invention obtains the Chinese medicine unguentum of embodiment 1 preparation, within 24 hours, changes dressings once, changes dressings continuously 3 times, should give wound surface debridement every time when changing dressings.
3. therapeutic outcome
This organizes 133 examples, and I degree is burnt 53 examples, all healed in 3-4 days.Shallow II degree is burnt 44 examples, deep ii degree burn 23 example, healing in 6~15 days.III degree is burnt 13 examples, healing in 20~42 days.II degree-III degree the patient of early hositalization is through debridement wrapping or exposes treatment, it does not have occur affecting healing because of inflammatory reaction.II degree-III degree the patient being admitted to hospital late period, because burn local occurs under infected tissue's liquefaction crust or empyema under crust, though through thorough debridement, local organization aoxidizes, but still inflammatory lesion impact healing occurs.Though the patient that this group only has 3 example III degree burns climbs raw Regeneration and Repair and self-heal through debridement circumferential edges skin peptide, but still leaves strip cicatrix.Clinic visits more than II degree half a year patient, it does not have other are uncomfortable.
Model case
Zhang, man, 31 years old, boiling water burn, wound was red and swollen, bubbles, affected part area 3 × 6cm, after giving the ointment of embodiment 2 preparation, fully recovers after 4 days, and scald place preventing from scar, and patient is in the process of the drug of topical application, it does not have pain and other sense of discomfort.
Listed above is only the best specific embodiment of the present invention.It is clear that the invention is not restricted to above example, it is also possible to there are many deformation.All deformation that those of ordinary skill in the art can directly derive from present disclosure or associate, are all considered as protection scope of the present invention.
Claims (4)
1., for an ointment for empyrosis, it is prepared from by following raw material:
Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Poria, Stigma Croci, Galla Chinensis, Radix Glycyrrhizae, Herba Violae, Fructus Forsythiae, Herba Patriniae, Herba Houttuyniae,
Herba Scutellariae Barbatae, Herba Taraxaci, Herba Hedyotidis Diffusae, Pseudobulbus Cremastrae Seu Pleiones, Rhizoma Paridis, Cacumen Platycladi, Fructus Gardeniae, the Radix Angelicae Dahuricae, Cortex Phellodendri, Herba Artemisiae Anomalae,
The Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Artemisiae Argyi, Cortex Moutan, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Notoginseng, the Rhizoma Atractylodis Macrocephalae, Flos Carthami, Rhizoma Chuanxiong, Semen Vaccariae, Lycopodium casuarinoides Spring, Fructus Tribuli.
2. ointment according to claim 1, it is characterised in that it is made by the raw material of following weight proportioning:
Rhizoma Polygoni Cuspidati 20-25 part, Radix Arnebiae (Radix Lithospermi) 20-25 part, Poria 20-25 part, Stigma Croci 20-25 part, Galla Chinensis 20-22 part,
Radix Glycyrrhizae 20-22 part, Herba Violae 18-20 part, Fructus Forsythiae 18-20 part, Herba Patriniae 18-20 part, Herba Houttuyniae 18-20 part,
Herba Scutellariae Barbatae 15-18 part, Herba Taraxaci 15-18 part, Herba Hedyotidis Diffusae 15-18 part, Pseudobulbus Cremastrae Seu Pleiones 15-18 part, Rhizoma Paridis 15-18 part, Cacumen Platycladi 12-15 part, Fructus Gardeniae 12-15 part, Radix Angelicae Dahuricae 12-15 part, Cortex Phellodendri 12-15 part, Herba Artemisiae Anomalae 12-15 part,
Pseudobulbus Bletillae (Rhizoma Bletillae) 10-12 part, Folium Artemisiae Argyi 10-12 part, Cortex Moutan 10-12 part, Radix Paeoniae Rubra 10-12 part, Radix Rehmanniae Preparata 10-12 part,
Radix Notoginseng 5-8 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Flos Carthami 5-8 part, Rhizoma Chuanxiong 5-8 part, Semen Vaccariae 5-8 part,
Lycopodium casuarinoides Spring 3-5 part, Fructus Tribuli 3-5 part.
3. the ointment described in claim 1-2, it is characterised in that the preparation method of described ointment is:
Each crude drug is weighed according to above-mentioned parts by weight;
(1) take tiger account, Stigma Croci, Herba Patriniae, Herba Houttuyniae, Herba Scutellariae Barbatae, Cacumen Platycladi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Rhizoma Chuanxiong mix in described ratio, add relative to 2 times of weight 95%(volume ratios of mixture) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of drying, it is ground into powder, is complex A;
(2) taking surplus stock medicine and add 5 times of weight water decoctions twice, 2 hours first times, second time 1 hour, merge twice filtrate, it is the extractum of 1.2g/ml that filtrate decompression dries acquisition density, after 80 DEG C of drying, is ground into powder, is complex B;
(3) Homogeneous phase mixing complex A and complex B obtains medicated powder, is stirred evenly by weight 1:1.5 mix with Oleum Sesami by medicated powder, to obtain final product.
4. the purposes of ointment described in claim 1-3.
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