CN109431842B

CN109431842B - Eczema cream for children

Info

Publication number: CN109431842B
Application number: CN201811441492.2A
Authority: CN
Inventors: 张立萌
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-11-28
Filing date: 2018-11-28
Publication date: 2022-01-18
Anticipated expiration: 2038-11-28
Also published as: CN109431842A

Abstract

The invention discloses an eczema cream for children, which comprises a plant extract, chlorhexidine, paeonol and a humectant; the plant extract comprises centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract, and the humectant comprises ceramide; the weight percentage content of the paeonol in the eczema cream for children is 0.005-0.05%; the content of the chlorhexidine in the eczema cream for children is 0.01-0.25 wt%. The eczema cream for children contains rich natural nourishing components, supplements nutrition required by skin, balances damaged skin, resists bacteria, eliminates eczema red spots, relieves sensitive skin, cares delicate and sensitive skin, and is particularly suitable for children.

Description

Eczema cream for children

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an eczema cream for children.

Background

The main causes of eczema are:

(1) environmental factors: many studies prove that environmental factors are one of the important causes of eczema, the environment includes group environment and individual environment, and the human group environment pathogenic factors refer to outdoor large-scale air, water, soil, radioactive source, large-scale sensitized pollen vegetation, large-scale airborne allergenic bacteria source and the like, such as: it is closely related to the contact with clothes, the eating environment, air pollution, etc.

(2) Infectious agents (associated with microbial infection): viruses and fungi are ubiquitous in daily life, and common staphylococcus aureus, candida albicans, malassezia, escherichia coli, alternaria alternate, penicillium chrysogenum, mycosporium, penicillium punctatum, fusarium, aspergillus fumigatus, aspergillus niger and the like are one of the causes of eczema; cause of infantile eczema.

(3) Dietary factors: one of the causes of eczema is diet. The food diversification and the food development are continuous, a plurality of foods with too high additive components appear, the eczema is easily caused, and particularly, some chemically synthesized foods such as saccharin, acetic acid, citric acid, essence, synthetic dye and the like are applied.

(4) Drug allergy: generally, any drug may cause eczematous drug eruptions, but the main common causes are: ethylenediamine antihistamines such as aminophylline, piperazine; ampicillin, such as amoxicillin, nickel, heparin and mercury, mainly cause Budd baboon syndrome; penicillin such as methyldopa.

(5) Genetic factors: certain types of eczema are closely related to inheritance.

Symptoms of eczema are:

(1) infant eczema: according to traditional Chinese medicine, psoriasis usually occurs in the second or third postnatal month, is easy to occur at the face and skin folds, can affect the whole body, generally gradually relieves to recover with age, but few cases continue to develop to childhood or even adult.

(2) Dry eczema: it is usually seen in thin infants, especially on the scalp and glabella, and is manifested as flushing, desquamation and pimple, but no obvious exudation, and also in chronic stage, it may be slightly infiltrated and thickened, with chap, scratch or scab, often causing crying and restless sleep due to paroxysmal severe pruritus.

(3) Anal eczema: eczema around anus is red and swollen and erosive in acute stage, infiltrates and becomes thick in chronic stage, even chaps occur, itching and pain occur, especially after defecation, skin can become thick or thin due to frequent scratching, atrophy and brightness occur, children anal eczema is often related to enterobiasis, adults are often related to hemorrhoids and hyperhidrosis.

(4) Eczema of hands: eczema at the finger tip often repeatedly causes blisters, scabbing, thickening and desquamation, and affects the nail bed, so that the nail plate is rough and uneven, and the eczema is aggravated by contact with water, soap, washing powder and the like.

(5) Eczema of legs and feet: the disease is easy to develop in the front of the shin and the ankle, which is often caused by varicose veins or trauma of the lower limbs, and the disease is manifested as scabbing, thickening and lichenification, erosion, water running, easy secondary infection or ulcer formation, and stubborn and difficult to treat.

(6) Eczema rhagadiforme: related to allergy, the disease condition can be aggravated by factors such as mental trauma, endocrine disturbance and the like in the disease process due to the contact of cleaning agents, soaps, dyes, paints, sunlight and other irritants in daily life.

The reason is as follows:

(1) comparing healthy skin structure to damaged skin barrier structure-healthy skin structure: the skin can keep moist for a long time, can resist external invasion, and is glossy and elastic; however, the damaged skin has excessive evaporation of water, is invaded by bacteria (such as staphylococcus aureus, candida albicans, malassezia and the like) and chemical substances, is damaged, has weakened self-protection capability, is easy to generate eczema, red and itchy skin and red spot spots, and is particularly easy to generate red buttocks, flush, desquamation, pimples and the like in young and tender infant skin.

(2) Human skin is affected by many factors: such as air, water, radioactive sources, etc. in the environment; most importantly, the skin is invaded by bacteria, and if the bacteria is greatly related to the infection of microorganisms, the tissue layer of the skin is damaged, so that the skin has skin problems of dry molting, skin chapping, itching, allergic eczema and the like; secondly, some people depend on the medicine excessively, so that the medicine is allergic, and the skin is in a problem; finally, some types of eczema are closely related to inheritance.

The annoyance of eczema: the biggest trouble is 'itching', which causes the extreme itching to be unbearable, uneasy to sit, unbearable to itch and go to sleep at night, the old itching is repeated and cannot treat the root cause, and the dampness-eliminating rash ointment sold on the market treats the symptoms and does not treat the root cause; in addition, skin pigment is thickened and discolored.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide the eczema cream for children.

In order to achieve the purpose, the invention adopts the technical scheme that: an eczema ointment for children comprises plant extract, chlorhexidine, paeonol and humectant; the plant extract comprises centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract, and the humectant comprises ceramide; the weight percentage content of the paeonol in the eczema cream for children is 0.005-0.05%; the content of the chlorhexidine in the eczema cream for children is 0.01-0.3 wt%.

The eczema cream for children has good bacteriostatic and itching relieving effects, can inhibit harmful bacteria from breeding on staphylococcus aureus, candida albicans, malassezia and escherichia coli, and can prevent bacteria from invading. When the paeonol and the chlorhexidine are added in the above amount, the bacteriostatic and antipruritic effects can be better exerted, and the paeonol and the chlorhexidine are particularly suitable for children.

The eczema cream for children contains plant extract components, can effectively treat skin and mucosa diseases, can promote the synthesis of fibroblasts and collagen cells, promote wound ulcer healing and blood circulation, and has the greatest characteristics of promoting skin repair capacity, improving resistance, inhibiting bacteria and diminishing inflammation, reducing scars and pigmentation and reducing skin allergy.

The eczema cream for children disclosed by the invention contains the ceramide as a moisturizing component, and can provide unprecedented strong moisturizing capability to skin; the skin care product has good water dispersibility, can keep moisture continuously, can improve skin feel quickly, can not be too oily, keeps fresh and moist, and can increase skin smoothness and softness immediately; improving the dryness and aging of skin, and making skin glossy.

As a preferable embodiment of the eczema cream for children, the content of paeonol in the eczema cream for children is 0.04% by weight; the content of the chlorhexidine in the eczema ointment for children is 0.2 percent by weight.

In a preferred embodiment of the eczema cream for children, the content of the plant extract in the eczema cream for children is 0.005-0.12% by weight. The plant extract can act together with paeonol and chlorhexidine by adopting the above addition amount, plays the role of bacteriostasis and sterilization, and is mild and non-irritant.

As a preferred embodiment of the eczema cream for children of the present invention, the ceramide is water-soluble ceramide; the weight percentage of the ceramide in the eczema cream for children is 0.1-1.5%. The water-soluble ceramide is composed of a mixture of ceramide 1, ceramide 2, ceramide 3, ceramide 4 and ceramide 6 II.

As a more preferable embodiment of the eczema ointment for children of the present invention, the ceramide is contained in the eczema ointment for children in an amount of 1% by weight. When the ceramide is added in the above amount, the moisturizing effect can be better exerted, and the wound healing is promoted.

As a preferred embodiment of the eczema cream for children of the present invention, the eczema cream for children further comprises dipotassium glycyrrhizinate and allantoin; the weight percentage content of the dipotassium glycyrrhizinate in the eczema cream for children is 0.001-1%; the weight percentage content of the allantoin in the eczema cream for children is 0.01-0.5%.

The eczema cream for children is added with dipotassium glycyrrhizinate and allantoin, and can improve the effects of sterilization, anti-inflammation and healing promotion.

As a preferable embodiment of the eczema cream for children, the content of the dipotassium glycyrrhizinate in the eczema cream for children is 0.05 percent by weight; the weight percentage content of the allantoin in the eczema cream for children is 0.15%.

As a preferred embodiment of the eczema cream for children of the present invention, the eczema cream for children further comprises panthenol, bisabolol, and menthol; the weight percentage content of the panthenol in the eczema cream for children is 0.1-1%, the weight percentage content of the bisabolol in the eczema cream for children is 0.0001-0.1%, and the weight percentage content of the menthol in the eczema cream for children is 0.01-0.5%.

The eczema cream for children is added with panthenol, bisabolol and menthol, so that the effects of sterilization, inflammation resistance and healing promotion can be improved, and the penetrability of skin to other medicines can be improved.

In a more preferred embodiment of the eczema pack for children of the present invention, the content of panthenol in the eczema pack for children is 0.5% by weight, the content of bisabolol in the eczema pack for children is 0.002% by weight, and the content of menthol in the eczema pack for children is 0.3% by weight.

As a preferred embodiment of the eczema cream for children, the eczema cream for children further comprises the following components in percentage by weight: 2-12% of glycerol, 1-7% of white petrolatum, 2-6% of C12-15 alcohol benzoate, 2-6% of liquid paraffin, 2-12% of propylene glycol, 2-6% of cetearyl alcohol, 2-6% of stearic acid, 2-5% of glyceryl stearate/PEG-100 stearate, 1-3% of sorbitan stearate, 601-3% of polysorbate-3%, 0.01-0.5% of camphor, 0.01-0.1% of triethanolamine, 0.1-0.6% of 1, 2-hexanediol and 0.1-0.6% of p-hydroxyacetophenone. The uniform and stable paste can be obtained by adopting the auxiliary material matrix.

As a preferred embodiment of the eczema cream for children of the present invention, the ratio by weight of the centella asiatica extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the tea leaf extract, the glycyrrhiza glabra root extract, the chamomile flower extract and the rosemary leaf extract is: centella asiatica extract: giant knotweed rhizome root extract: radix scutellariae extract: tea extract: glycyrrhiza glabra root extract: mother chrysanthemum extract: the rosemary leaf extract is 5:2:2:1:1:0.5: 0.5.

The invention has the beneficial effects that: the invention provides eczema cream for children. The eczema cream for children contains rich natural nourishing components, supplements nutrition required by skin, balances damaged skin, resists bacteria, eliminates eczema red spots, relieves sensitive skin, cares delicate and sensitive skin, and is particularly suitable for children.

Detailed Description

Each of the raw materials in the examples was purchased from the market.

The product model of glyceryl stearate/PEG-100 stearate is LONZEST MSA/LPK-200; the submicron lipid particle of paeonol was purchased from Suzhou Nakang Biotech Co., Ltd, and contains 5% of paeonol. The plant extract is purchased from Guangzhou Rui Yu chemical technology Limited company and has a commercial model of CalmYang, wherein the weight ratio of the centella asiatica extract to the polygonum cuspidatum root extract to the scutellaria baicalensis root extract to the tea extract to the glycyrrhiza glabra root extract to the chamomile flower extract to the rosemary leaf extract is as follows: centella asiatica extract: giant knotweed rhizome root extract: radix scutellariae extract: tea extract: glycyrrhiza glabra root extract: mother chrysanthemum extract: the rosemary leaf extract is 5:2:2:1:1:0.5: 0.5.

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Examples 1 to 5 and comparative examples 1 to 5

The formulations of the eczema creams for children described in examples 1 to 5 and comparative examples 1 to 5 are shown in Table 1.

The preparation method of the eczema cream for children in the embodiment 1 comprises the following steps:

s1, putting petrolatum, C12-15 alcohol benzoate, liquid paraffin, cetostearyl alcohol, stearic acid, LONZEST MSA/LPK-200, sorbitan stearate, polysorbate-60, bisabolol, chlorhexidine, water-soluble ceramide, 1, 2-hexanediol, paeonol submicron lipid particles and triethanolamine into a main pot, heating to 80-85 ℃, stirring and dissolving completely to obtain a material A, and preserving heat for later use;

s2, adding water, glycerol, propylene glycol, panthenol, allantoin, p-hydroxyacetophenone and dipotassium glycyrrhizinate into a main pot, starting stirring and heating to 85-90 ℃, keeping the temperature until the materials are completely dissolved, then starting a vacuum valve to pump S1 into the main pot, homogenizing for 5-8 min, keeping the temperature and stirring for 10min, and then starting cooling;

and S3, continuously cooling to 45 ℃, adding CalmYang, camphor and menthol, stirring uniformly, sampling, detecting, discharging after qualified to obtain the eczema cream for children.

The preparation methods of the eczema cream for children described in examples 2 to 5 and comparative examples 1 to 5 refer to the preparation method of example 1.

TABLE 1 formulation of eczema cream for children described in examples 1 to 5 and comparative examples 1 to 5

Example 6

The tests show that the eczema cream for children in the examples 1 to 5 and the comparative examples 1 to 5 meet the relevant requirements of QB/T1857-.

Product safety evaluation (human body skin patch experiment)

Firstly, testing a test article: eczema cream for children described in examples 1 to 5 and comparative examples 1 to 5

Number of test population: 50, 22 men, 28 women

Age: between 3 and 16 years old

Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.

Grouping: 10 groups of 5 people each, mean age 10 ± 2 years.

Secondly, a spot pasting method: selecting a qualified spot tester, dripping 0.020 g-0.025 g of a tested object into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the tested object is removed respectively, and recording the results according to the skin reaction grading standard in the cosmetic hygiene standard.

Thirdly, experimental results: the result of the human body skin patch test shows that: each group of subjects pass the spot-pasting test of the eczema cream for children described in examples 1-5 and comparative examples 1-5, and skin reactions are observed at 0.5, 6, 12, 24 and 48 hours, wherein 0 case has adverse skin reactions, which indicates that the eczema cream for children is safe to use.

Evaluation of product Effect

Firstly, testing a test article: 50 children volunteers diagnosed with eczema were collected and divided into 10 groups, 5 persons in each group, 1 to 5 persons were applied to the eczema part for two weeks and the children eczema cream described in comparative examples 1 to 5 were used, the change of itching, erythema and pimple before and after application was compared, the itching was measured by the volunteer's self-sensation, the degree of redness was measured by comparing pictures, the number of pimples was calculated by the area of skin, the test result was expressed by comparing with the original value, each parameter was the average value of patients, the original value was the value before application and was defined as 100, wherein the original value of the degree of itching was 100, the slight decrease was defined as 70, the decrease was 50, the significant decrease was defined as 20, and the test result was shown in table 2.

TABLE 2 eczema ointment for children use effect

As can be seen from the data in table 2, the eczema ointments for children described in examples 1 to 5 have a certain effect on treatment and relief of eczema, can relieve erythema and pimple symptoms, and relieve itching, wherein the use effect of example 1 is the best, compared with example 1, the use effects of comparative examples 1 to 3 are slightly poor, and have a certain relationship with the proportion of chlorhexidine and paeonol in the eczema ointments for children, the effect is better when the chlorhexidine and the paeonol are used in combination, the addition amount of the paeonol is 0.005 to 0.05%, and the effect is better when the addition amount of the chlorhexidine is 0.01 to 0.25%. Compared with example 1, examples 4 and 5 and comparative examples 4 and 5 have slightly poor using effect, which shows that the using effect of the eczema ointment for children is influenced by the plant extract, dipotassium glycyrrhizinate, allantoin and water-soluble ceramide.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. An eczema ointment for children is characterized by comprising plant extracts, chlorhexidine, paeonol submicron lipid particles and a humectant; the plant extracts comprise centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, chamomile flower extract and rosemary leaf extract; the weight ratio of the centella asiatica extract to the polygonum cuspidatum root extract to the scutellaria baicalensis root extract to the tea leaf extract to the glycyrrhiza glabra root extract to the chamomile flower extract to the rosemary leaf extract is as follows: centella asiatica extract: giant knotweed rhizome root extract: radix scutellariae extract: tea extract: glycyrrhiza glabra root extract: mother chrysanthemum extract: rosemary leaf extract =5:2:2:1:1:0.5: 0.5; the humectant comprises a water-soluble ceramide; the eczema cream for children also comprises dipotassium glycyrrhizinate and allantoin; the weight percentage content of the paeonol submicron lipid particle in the eczema ointment is 0.8%; the chlorhexidine accounts for 0.2 percent of the weight of the eczema cream for children; the weight percentage content of the plant extract in the eczema cream for children is 0.01 percent; the weight percentage content of the water-soluble ceramide in the eczema cream for children is 1%; the weight percentage content of the dipotassium glycyrrhizinate in the children eczema cream is 0.05 percent; the weight percentage content of the allantoin in the eczema cream for children is 0.15%; the eczema cream for children also comprises the following components in percentage by weight: panthenol 0.5%, bisabolol 0.002%, menthol 0.3%, glycerin 10%, white petrolatum 5%, C12-15 alcohol benzoate 5%, liquid paraffin 4%, propylene glycol 6%, cetostearyl alcohol 3%, stearic acid 3%, glyceryl stearate/PEG-100 stearate 2.5%, sorbitan stearate 2%, polysorbate-601%, camphor 0.2%, triethanolamine 0.05%, 1, 2-hexanediol 0.4%, p-hydroxyacetophenone 0.4%; the paeonol submicron lipid particle contains 5 percent of paeonol by weight percentage.