CN110090190B - Soothing cooling liquid for baby plants and preparation method thereof - Google Patents
Soothing cooling liquid for baby plants and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a soothing cooling liquid for infants and children and a preparation method thereof. The infant plant relieving and cooling liquid comprises the following components in percentage by mass: 4-12% of 1, 3-propylene glycol, 1-6% of butanediol, 1-5% of oat kernel extract, 2-8% of 1, 2-pentanediol, 1-5% of menthyl lactate, 1-5% of CalmYang composite plant soothing essence, 0.5-2.5% of beta-glucan, 0.1-0.6% of argy wormwood leaf oil, 0.1-0.5% of aloe barbadensis powder and 0.1-0.5% of dipotassium glycyrrhizinate. The invention utilizes the specificity of 1, 2-pentanediol under a certain amount to promote the permeability of the oat kernel extract and the CalmYang, the oat kernel extract and the CalmYang plant extract have good synergistic interaction, the used functional components are all plant sources, no chemical preservative is added, and the invention can quickly relieve itching and is mild and non-irritant.
Description
Technical Field
The invention relates to a skin care product, in particular to a soothing cooling liquid for infants and children and a preparation method thereof.
Background
Due to the reasons of thin skin, weak barrier function, weak external stimulation resistance and the like of the infants, the infants are very easy to have skin itch, stabbing pain and other reactions, and the cool and refreshing product for quickly relieving itching is more and more popular with mothers.
At present, the soothing and itching-relieving products for babies mainly comprise cream and water aqua. The aqua products have the fastest itching relieving efficiency, so that a plurality of products are available, in order to seek for quick itching relieving, medicinal diphenhydramine hydrochloride is added into the formula, menthol, borneol, alcohol and the like are artificially synthesized, and the product containing medicinal and chemical synthesis components is used for a long time, so that the skin is easy to generate dependence, and certain damage is caused to the skin of infants. Plant extracts are also used for relieving itching and cooling in the market, the overall safety is improved, but the plant extracts are not easy to be absorbed by the skin, so that the product has slow effect and unsatisfactory itching relieving effect.
In conclusion, the existing relieving and itching-relieving refreshing aqueous solution products on the market have the advantages and the disadvantages. Therefore, the development of the infant and child plant relieving cooling liquid which is safe to use and quick in effect has important practical significance.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the infant plant relieving and cooling liquid.
The invention also aims to provide a preparation method of the baby plant soothing and cooling liquid.
The purpose of the invention is realized by the following technical scheme:
the infant plant relieving and cooling liquid comprises the following components in percentage by mass: 4-12% of 1, 3-propylene glycol, 1-6% of butanediol, 1-5% of oat kernel extract, 2-8% of 1, 2-pentanediol, 1-5% of menthol lactate, 1-5% of CalmYang composite plant soothing essence, 0.5-2.5% of beta-glucan, 0.1-0.6% of blumea oil, 0.1-0.5% of aloe barbadensis powder and 0.1-0.5% of dipotassium glycyrrhizinate.
The infant plant relieving and cooling liquid also comprises substances with bacteriostatic functions.
The substance with bacteriostatic function is preferably a substance whose active ingredient is mainly caprylhydroxamic acid, such as caprylhydroxamic acid & caprylyl glycol & glycerin, caprylhydroxamic acid & caprylic acid caprylate & methyl propylene glycol, caprylhydroxamic acid & caprylic acid caprylate & glycerin, caprylhydroxamic acid & ethylhexyl glycerin & methyl propylene glycol, caprylhydroxamic acid & caprylyl glycol &1,3 propylene glycol, or caprylhydroxamic acid &1,3 propylene glycol; more preferably caprylhydroxamic acid &1,3 propanediol (Zeastat).
The content of the substance with the antibacterial function in the infant and child plant soothing and cooling liquid is preferably 0.5-2% by mass.
The infant plant soothing and cooling liquid preferably comprises the following components in percentage by mass: 6-10% of 1, 3-propylene glycol, 2-4% of butanediol, 2-4% of oat kernel extract, 3-7% of 1, 2-pentanediol, 2-4% of menthol lactate, 2-4% of CalmYang composite plant soothing essence, 1-2% of beta-glucan, 0.2-0.5% of argy oil, 0.2-0.4% of aloe barbadensis powder, 0.2-0.4% of dipotassium glycyrrhizinate and 0.8-1.6% of Zeastat; more preferably comprises the following components in mass percent: 6-8% of 1, 3-propylene glycol, 3-3.5% of butanediol, 2-3% of oat kernel extract, 4-5% of 1, 2-pentanediol, 2-3% of menthol lactate, 2.2-3% of CalmYang, 1.5-1.8% of beta-glucan, 0.2-0.35% of argy wormwood leaf oil, 0.25-0.3% of aloe barbadensis powder, 0.2-0.3% of dipotassium glycyrrhizinate and 0.8-1.25% of Zeastat.
The infant plant relieving and cooling liquid also comprises water.
The balance of the water is the balance. The balance means that the sum of water and other components is 100% by mass.
The preparation method of the baby plant soothing and cooling liquid comprises the following steps:
(1) adding 1, 3-propylene glycol, Aloe barbadensis Miller powder and beta-glucan into water, and stirring to obtain a uniform system as phase A;
(2) uniformly stirring oat kernel extract, CalmYang composite plant soothing essence, 1, 2-pentanediol and menthol lactate to obtain a phase B;
(3) mixing butanediol with oleum folium Artemisiae Argyi to obtain transparent liquid as phase C; when the substance with the bacteriostatic function is contained, butanediol, blumea oil and the substance with the bacteriostatic function are mixed to obtain transparent liquid as a C phase;
(4) adding phase B into phase A, stirring to obtain transparent liquid, adding phase C and dipotassium glycyrrhizinate, mixing, and homogenizing to obtain the final product.
The water in the step (1) is preferably deionized water.
The homogenization conditions in step (4) are preferably as follows: the homogenizing speed is 2000 r/min.
The time for homogenization in step (4) is preferably 1 min.
According to the preparation method of the baby plant soothing and cooling liquid, the temperature in the whole preparation process is preferably controlled below 45 ℃. The objective is to reduce the disruption of activity of plant extract ingredients.
Compared with the prior art, the invention has the following advantages and effects:
1. the plant soothing and cooling liquid for infants and children does not contain chemical preservatives or alcohol, and the plant soothing essence components are used for replacing medicinal or chemically synthesized soothing antipruritic agents, so that the safety of the soothing and cooling liquid is improved, and the risk of generating irritation is reduced.
2. The functional components used for soothing and cooling the infant and child plants, namely the oat kernel extract, the menthol lactate, the centella asiatica extract, the chamomile extract, the glycyrrhiza glabra root extract, the tea leaf extract, the polygonum cuspidatum root extract, the rosemary leaf extract, the scutellaria baicalensis root extract, the glucan, the aloe barbadensis leaf powder and the dipotassium glycyrrhizinate are all plant sources, and are mild and non-irritant.
3. According to the infant plant soothing and cooling liquid, the principle that a certain amount of 1, 2-pentanediol can increase skin permeability is utilized, so that the plant soothing essence component of the formula obtains good bioavailability, the plant soothing essence component can rapidly enter the skin, the effect of relieving itching quickly is achieved, and the current situation that the relieving and itching relieving efficiency is low due to the single use of the plant extract is obviously improved.
Drawings
FIG. 1 is a graph showing the results of HPLC-UV quantitative analysis of bioavailability of each of the observed indicators of example 1 and comparative examples 1 to 4.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to embodiments and the accompanying drawings, but those skilled in the art will understand that the following embodiments and examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. Those who do not specify the conditions are performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The infant plant soothing and cooling liquid provided by the embodiment of the invention comprises the following components in parts by weight:
oat kernel extract: the avenoyl anthranilic acid in oats provides temporary protection to the skin, and relieves minimal pain and itching caused by poison ivy, poison oak, poison sumac and mosquito bites, and also relieves itching caused by dry skin. Oat kernel extracts used in the examples of the present invention were from demi.
calmYang: is prepared from herba Centellae extract, rhizoma Polygoni Cuspidati extract, Scutellariae radix extract, folium Camelliae sinensis extract, radix Glycytthizae extract, herba Rosmarini officinalis extract, and flos Matricariae Chamomillae extract, and has antioxidant, antiinflammatory, allergy relieving, and skin tranquilizing effects. The calmsang used in the examples of the present invention was from the hundred o stedt corporation of korea.
Beta-glucan: the effective components extracted from Agaricus campestris (Schizophyllum commune) can promote wound healing, moisturize, sunburn repair, collagen synthesis, cell proliferation, and immunoregulation. The beta-glucan used in the examples of the present invention was from behabo corporation.
Aloe vera leaf powder: fresh pure plants are extracted, and the skin care product is mild and pure, and can relieve common skin redness of the skin of a baby. The aloe vera leaf powder used in the examples of the present invention is from kalun chemical limited, guangzhou city.
Dipotassium glycyrrhizinate: effective components of Glycyrrhrizae radix are extracted, and the extract has antiallergic and antiinflammatory effects. The dipotassium glycyrrhizinate used in the examples of the present invention was obtained from the company macifu.
1, 2-pentanediol: the humectant has excellent performance, has antiseptic effect, can be used for preparing antiseptic-free products, and reduces allergy caused by the antiseptic. The 1.2-pentanediol has the functions of corrosion prevention, synergism and permeation promotion. The 1.2-pentanediol used in the examples of the present invention was obtained from Doxz corporation.
Zeastat: caprylyl hydroximic acid &1,3 propylene glycol is an antiseptic system designed and developed for preservative-free cosmetics and personal care products, has a good moisturizing effect and a bacteriostatic effect, and can ensure that the system inhibits the growth of microorganisms and ensures the product quality under the condition of not adding a preservative. Zeastat used in embodiments of the present invention is available from England Dies, USA.
Example 1
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Stirring 2% oat kernel extract, 2.2% CalmYang, 5% 1, 2-pentanediol and 2% menthyl lactate to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Example 2
(1) Adding 8% 1, 3-propylene glycol, 0.3% Aloe barbadensis Miller powder and 1.5% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Stirring 3% oat kernel extract, 3% CalmYang, 4% 1, 2-pentanediol and 3% menthyl lactate to obtain phase B.
(3) 3.5% of butanediol, 1.25% of Zeastat and 0.35% of argy wormwood leaf oil were mixed to obtain a clear liquid as a C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.3% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 1
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Stirring 2% oat kernel extract, 2.2% CalmYang and 2% menthyl lactate to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 2
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Stirring 2% oat kernel extract, 2.2% CalmYang, 5% 1, 2-hexanediol and 2% menthyl lactate to obtain phase B.
(3) 3% butanediol, 0.8% Zeastat (caprylhydroxamic acid) and 0.2% argy wormwood oil were mixed to obtain a clear liquid as a C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 3
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Stirring 2% oat kernel extract, 2.2% CalmYang, 10% water-soluble azone and 2% menthyl lactate to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 4
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) And stirring 2% diphenhydramine hydrochloride and 2% menthyl lactate uniformly to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 5
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) Mixing 2% oat kernel extract, 5% 1, 2-pentanediol and 2% menthyl lactate, and stirring to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Comparative example 6
(1) Adding 6% 1, 3-propylene glycol, 0.25% Aloe barbadensis Miller powder and 1.8% beta-glucan into water, and stirring to obtain homogeneous system as phase A.
(2) CalmYang 2.2%, 1, 2-pentanediol 5% and menthyl lactate 2% were stirred well to obtain phase B.
(3) The transparent liquid obtained by mixing 3% of butanediol, 0.8% of Zeastat and 0.2% of argy wormwood leaf oil was used as the C phase.
(4) Adding the phase B into the phase A, fully stirring to obtain transparent liquid, adding the phase C and 0.2% dipotassium glycyrrhizinate, mixing, and homogenizing at 2000r/min for one minute to obtain the baby plant relieving and cooling liquid.
To reduce the damage to the activity of the plant extract components, the temperature of all the whole preparation process is controlled below 45 ℃.
Effects of the embodiment
1. And (3) bioavailability test: evaluation of the penetration of the formulations of example 1 and comparative examples 1 to 4 into the skin
Experimental materials: in vitro wistar rat skin made into 4cm2The large and small skin pieces are washed clean with normal saline and stored in a refrigerator at-20 ℃, and the rat skin is detected before the experiment, and no damage can be seen by naked eyes.
The experimental method comprises the following steps: the diffusion area was 2.45cm using a modified Franz diffusion chamber2Stirring at a constant speed of 150 r/min. The treated rat skin was fixed between a supply tank and a receiving tank of a diffusion cell with the stratum corneum surface facing the supply tank, 3ml of the example or comparative sample was added to the supply tank, and distilled water was added to the receiving tank. The water bath temperature is 37 +/-1 ℃, 10ml of the receiving solution is precisely absorbed into a beaker at 10min, 30min and 100min respectively, and 10ml of normal saline is immediately supplemented at the same time. The receiving solution was filtered through a microporous membrane, and the amount of the filtrate in example 1 and comparative example was quantitatively analyzed by HPLC-UVExamples 1-3HPLC-UV observations Total oat kernel extract and CalmYang, comparative example 4HPLC-UV observations diphenhydramine hydrochloride (note: good permeability by itself) was analyzed.
And (3) test results: as can be seen from fig. 1, the bioavailability of example 1 is relatively close to that of comparative example 4, and comparative example 4 replaces the pentylene glycol oat kernel extract and calmsang with the chemically synthesized antipruritic diphenhydramine hydrochloride, thus illustrating that the permeability of oat kernel extract and calmsang in example 1 is relatively close to that of diphenhydramine hydrochloride in comparative example 4.
Example 1 in comparison with comparative example 1, comparative example 1 does not contain 1, 2-pentanediol and the bioavailability is significantly different by more than several times, thus illustrating that 1, 2-pentanediol has the effect of promoting the permeability of oat kernel extract and calmsang.
Example 1 in comparison to comparative example 2, comparative example 2 used 1, 2-hexanediol instead of 1, 2-pentanediol, but the bioavailability of comparative example 2 was relatively low, indicating that other polyols did not have significant penetration enhancing effects on oat kernel extract and calmsang.
Example 1 in comparison with comparative example 3, comparative example 3 was a skin penetrating agent, water soluble azone, instead of 1, 2-pentanediol, but the bioavailability of comparative example 3 was still relatively low, indicating that the skin penetrating agent did not significantly enhance penetration of oat kernel extract and calmsang.
In summary, the following steps: the permeability of oat kernel extract and CalmYang in the presence of 1, 2-pentanediol was similar to that of the chemically synthesized antipruritic diphenhydramine hydrochloride. 1, 2-pentanediol is uniquely effective in enhancing the permeability of oat kernel extract and CalmYang.
2. Safety test
The test method comprises the following steps: according to a skin irritation/corrosivity test method of ' cosmetic hygiene code ' 2007 edition of the ministry of health of the people's republic of China, the general-grade New Zealand rabbits (two male and female, provided by the three-water base of the Guangdong province medical laboratory animal center) qualified for quarantine are directly used for the skin irritation test. Before the test, the hair on both sides of the spine of the experimental animal is cut off, and the hair removing range is about 3cm multiplied by 3cm respectively. About 0.5g of the infant soothing and cooling liquid prepared in the examples or comparative examples is smeared on the skin of the left side of an animal, the smearing area is about 2.5cm multiplied by 2.5cm, the liquid is smeared once a day for 14 days continuously, and the other side of the liquid is used as a blank control. Shearing hair before smearing every day from the next day, removing residual infant soothing and cooling liquid with purified water, treating the control area in the same way, and observing the result 1h after smearing.
TABLE 1 skin irritation Strength grading
| Integral mean value | Strength of |
| 0～＜0.5 | Has no irritation |
| 0.5～＜2.0 | Light irritation |
| 2.0～＜6.0 | Middle irritation |
| 6.0～8.0 | Strong irritation |
TABLE 2 New Zealand rabbits multiple skin irritation test results
| Sample (I) | Example 1 | Example 2 | Comparative example 3 | Comparative example 4 |
| Mean of daily score for each animal | 0 | 0.12 | 0.93 | 0.45 |
The above data (tables 1 and 2) are provided by the Guangdong provincial underwriting test center test.
The test results show that the soothing cooling liquid prepared in example 1, example 2 and comparative example 4 has no irritation according to the skin irritation intensity grading standard, the data of example 1 and example 2 are superior to the data of comparative example 4 using a chemically synthesized antipruritic agent, and the safety of the plant soothing cooling liquid using 1, 2-pentanediol together with oat kernel extract and CalmYang is slightly better than that of the soothing cooling liquid using the chemical antipruritic agent diphenhydramine hydrochloride.
Comparative example 3 the soothing and cooling liquid prepared in example 1 and example 2 has light irritation, and 1, 2-pentanediol is used as a penetration enhancer, so that the safety of the 1, 2-pentanediol is obviously better than that of water-soluble azone used as a skin penetrating agent.
3. Efficacy test
100 volunteers (mother and infant) were selected and the example samples were changed every two months during the period from 2 months to 10 months, and the example efficacy evaluation statistics were collected every two months.
TABLE 3 evaluation results of efficacy of soothing, itching-relieving and refreshing liquid
Efficacy test results: as can be seen from table 3, the evaluation of the relieving itching effect and the relieving itching time of example 1 and example 2 and the comparative example 4 have no obvious difference, which indicates that the relieving and cooling liquid prepared by using pentanediol together with the oat kernel extract and the CalmYang plant extract is very close to the relieving and cooling liquid prepared by using diphenhydramine hydrochloride in the relieving and itching effect. In the test of whether there was irritation during use, examples 1 and 2, which were prepared using the plant soothing essence, were slightly superior to comparative example 4, which was prepared using a chemically synthesized anti-itching agent.
Comparing example 1 with comparative example 5 and comparative example 6, it can be seen that comparative example 5 (lacking the CalmYang) and comparative example 6 (lacking the oat kernel extract) have far lower skin soothing and itching relieving effects than example 1 due to the lack of one component in the raw material formulation, thereby illustrating that the oat kernel extract and the CalmYang plant extract have good synergistic effect under the condition of 5% of 1,2 pentanediol for promoting penetration.
While the preferred embodiments and examples of the present invention have been described in detail, the present invention is not limited to the embodiments and examples described above, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (5)
1. The infant plant relieving and cooling liquid is characterized by comprising the following components in percentage by mass: 4-12% of 1, 3-propylene glycol, 1-6% of butanediol, 1-5% of oat kernel extract, 2-8% of 1, 2-pentanediol, 1-5% of menthyl lactate, 1-5% of CalmYang composite plant soothing essence, 0.5-2.5% of beta-glucan, 0.1-0.6% of argy wormwood leaf oil, 0.1-0.5% of aloe barbadensis powder, 0.1-0.5% of dipotassium glycyrrhizinate, 0.5-2% of substance with an antibacterial function and the balance of water;
the CalmYang composite plant soothing essence consists of a centella extract, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea extract, a glycyrrhiza glabra root extract, a rosemary leaf extract and a chamomile flower extract;
the substance with the bacteriostatic function is Zeastat, and the Zeastat consists of caprylhydroxamic acid and 1, 3-propylene glycol.
2. The soothing and cooling liquid for infants and young plants as claimed in claim 1, which is characterized by comprising the following components in percentage by mass: 6-10% of 1, 3-propylene glycol, 2-4% of butanediol, 2-4% of oat kernel extract, 3-7% of 1, 2-pentanediol, 2-4% of menthyl lactate, 2-4% of CalmYang composite plant soothing essence, 1-2% of beta-glucan, 0.8-1.6% of Zeastat, 0.2-0.5% of blumea oil, 0.2-0.4% of aloe barbadensis powder, 0.2-0.4% of dipotassium glycyrrhizinate and the balance of water.
3. The soothing and cooling liquid for infants and young plants as claimed in claim 2, which is characterized by comprising the following components in percentage by mass: 6-8% of 1, 3-propylene glycol, 3-3.5% of butanediol, 2-3% of oat kernel extract, 4-5% of 1, 2-pentanediol, 2-3% of menthol lactate, 2.2-3% of CalmYang composite plant soothing essence, 1.5-1.8% of beta-glucan, 0.2-0.35% of argy leaf oil, 0.25-0.3% of aloe barbadensis powder, 0.2-0.3% of dipotassium glycyrrhizinate, 0.8-1.25% of Zeastat and the balance of water.
4. A method of preparing a soothing and cooling liquid for infants and young children as claimed in any one of claims 1 to 3, wherein the method comprises the following steps: the method comprises the following steps:
(1) adding 1, 3-propylene glycol, Aloe barbadensis Miller powder and beta-glucan into water, and stirring to obtain a uniform system as phase A;
(2) uniformly stirring oat kernel extract, CalmYang composite plant soothing essence, 1, 2-pentanediol and menthyl lactate to obtain a phase B;
(3) mixing butanediol, oleum folium Artemisiae Argyi and substance with antibacterial function to obtain transparent liquid as phase C;
(4) adding phase B into phase A, stirring to obtain transparent liquid, adding phase C and dipotassium glycyrrhizinate, mixing, and homogenizing to obtain infantile plant relieving and cooling liquid;
all the temperature of the whole preparation process is controlled below 45 ℃.
5. The method for preparing a soothing and refreshing liquid for infants and young children according to claim 4, wherein the method comprises the following steps: the homogenization conditions in the step (4) are as follows: the homogenizing speed is 2000r/min, and the homogenizing time is 1 min.
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| CN110478296A (en) * | 2019-09-20 | 2019-11-22 | 杭州雅妍化妆品有限公司 | With the preparation method for the phalacrosis prevention and hair generation essence agent that Cacumen Platycladi extract is main effective component |
| CN110742844B (en) * | 2019-11-26 | 2021-02-19 | 苏州东方之宝生物药业有限公司 | Multi-effect talcum powder and preparation method thereof |
| CN111529468A (en) * | 2020-06-02 | 2020-08-14 | 徐志邦 | Water-replenishing and moisture-preserving mask essence and preparation method thereof |
| CN111821231A (en) * | 2020-06-19 | 2020-10-27 | 广州艾蓓生物科技有限公司 | Refreshing composition and preparation method thereof |
| CN113576952A (en) * | 2021-09-02 | 2021-11-02 | 广州葆妍生物科技有限公司 | Moisturizing repair composition for skin of infants and children and preparation method and application thereof |
| CN115813840A (en) * | 2022-12-27 | 2023-03-21 | 福建省梦娇兰日用化学品有限公司 | Children soothing gel containing oat extract and preparation method thereof |
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