CN103432584A - Cooling and itching relieving composition and paper towel employing same - Google Patents
Cooling and itching relieving composition and paper towel employing same Download PDFInfo
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- CN103432584A CN103432584A CN2013103526743A CN201310352674A CN103432584A CN 103432584 A CN103432584 A CN 103432584A CN 2013103526743 A CN2013103526743 A CN 2013103526743A CN 201310352674 A CN201310352674 A CN 201310352674A CN 103432584 A CN103432584 A CN 103432584A
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Abstract
The invention relates to a cooling and itching relieving composition which comprises at least one antipruritic agent, at least one freshener and at least one transdermal enhancer, wherein the mass ratio of the antipruritic agent to the freshener to the transdermal enhancer is 0.1-20 to 0.1-30 to 30-80; the percentage by mass of a hydrophobic lipophilic substance in the cooling and itching relieving composition reaches at least 60 percent. The invention also provides a paper towel applying the cooling and itching relieving composition. The cooling and itching relieving composition disclosed by the invention is prepared by selecting the antipruritic agent, the freshener and the transdermal enhancer according to a specific ratio and takes good cooling and itching relieving effects. Moreover, when the cooling and itching relieving composition disclosed by the invention is transferred to the surface of paper, a plurality of points distributed at intervals are formed on the surface of the paper, so that when the paper is used for wiping the skin, the cooling and itching relieving composition on the paper is very easy to transfer onto the skin.
Description
Technical field
The present invention relates to a kind of refrigerant antipruritic compositions and apply the napkin of this refrigerant antipruritic compositions.
Background technology
Skin pruritus can be brought discomfort to the people usually, when serious, even can hinder orthobiosis.The reason that causes skin pruritus includes endocrine disturbance, pruritus hiemalis, hepatorenal disease, malignant tumor, spirituality factor, skin degreaser drying, mosquito bite etc.
At present, the medicine for the treatment of/releasing skin pruritus is mainly to take orally and two kinds of externals.Generally, the medicine of orally taken for curing pruritus can produce some side effect beastly, such as drowsiness, tired out sense or digestive system obstacle etc.; And the article of external are mainly some water, condensation, paste, be substantially all outer painting, outer wiping articles for use, user, by topical drug being transferred to the pruritus position, is then rubbed out it by finger.Medicine for external use does not generally have significant side effect, but it carries inconvenience.
Summary of the invention
In view of this, be necessary to provide a kind of refrigerant antipruritic compositions, it can be applicable to napkin and can be convenient for carrying, and can play refrigerant antipruritic effect.
In addition, also be necessary to provide a kind of napkin that is added with above-mentioned refrigerant antipruritic compositions.
A kind of refrigerant antipruritic compositions, it contains at least one pruritus, at least one freshener and at least one transdermal enhancer, and the mass ratio of wherein said pruritus, freshener, transdermal enhancer is 0.1～20:0.1～30:30～80; In this refrigerant antipruritic compositions the quality percentage composition of hydrophobic lipophilicity substance reach 60% and more than.
A kind of napkin of applying above-mentioned refrigerant antipruritic compositions, this refrigerant antipruritic compositions directly puts at least one surface of paper, and this refrigerant antipruritic compositions forms a plurality of points spaced apart at paper surface.
Refrigerant antipruritic compositions of the present invention, by selecting pruritus, freshener and transdermal enhancer formulated according to specific ratio, plays good refrigerant itching-relieving efficacies.In addition, when transferring to paper surface, refrigerant antipruritic compositions of the present invention can as the water solublity formula is transferred on paper, not spread, but form a plurality of points spaced apart at paper surface, during paper wiping skin, the refrigerant antipruritic compositions on paper is easy to transfer on skin like this.
The specific embodiment
Refrigerant antipruritic compositions involved in the present invention, it contains at least one pruritus, at least one freshener, at least one transdermal enhancer, the mass ratio of wherein said pruritus, freshener, transdermal enhancer is 0.1～20:0.1～30:30～80, is preferably 1～10:1～15:50～80.
Like this, be difficult for diffusion when this refrigerant antipruritic compositions is transferred to paper surface, but form a plurality of points that contain compositions at paper surface, during paper wiping skin, the refrigerant antipruritic compositions on paper is easy to transfer on skin like this.
This pruritus can make in human body the chemical mediator that causes pruritus reduce, thereby the permeability of blood capillary and lysosome membrane is reduced, thereby makes tissue fluid ooze out minimizing, and last skin pruritus symptom alleviates and disappears.
This pruritus is selected from terpinenol-4, Artemisia alcohol, linalool, cineole, phellandrene, Bi Cheng adds alkene, thujanol, mequitazine, Cyproheptadine, doxepin, cimetidine, ichthyol, crotamiton, antol (Sumitomo), chlorphenamine maleate, dexbrompheniramine maleate, indomethacin, diphhydramine hydrochloride, dexamethasone, dexamethasone acetate, methylprednisolone acetate, the propanoic acid dexamethasone, dexamethasone acetate, prednisolone acetate, prednisolone valerate acetate, hydrocortisone acetate, triamcinolone acetonide acetate, Borneolum Syntheticum, Oleum Caryophylli, litsea cubeba oil, paeonol, Radix Sophorae Flavescentis extract, Fructus cnidii extract, Fructus Kochiae extract, Herba Schizonepetae extract, Radix Saposhnikoviae extract, Radix Scutellariae extract, Folium perillae extract, Folium Artemisiae Argyi extract, the Cortex cercis chinensis extract, Cortex Meliae extract, Rhizoma Bistortae extract, at least one in Alumen extract and Bulbus Allii extract.
This freshener can chafe Cold receptor, give skin refrigerant pleasant sensation.
This freshener can be selected from least one in natural plant extract, is specially at least one being selected from Fructus Piperis peppermint oil, oleum menthae viridis, Oleum menthae, Mentholum, Camphora, eucalyptus oil, chrysanthemum extract liquid, Borneolum Syntheticum, Rhizoma Picrorhizae extract, Cortex Dictamni extract, Olibanum oil, parsley oil, Oleum Anisi Stellati, wintergreen oil, Oleum Cinnamomi, Fructus Citri Limoniae oil, orange peel oil, Cardamom oil, Fructus Coriandri oil, Pericarpium Citri Reticulatae oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, caraway seed oil, cassia oil, Indian oil of verbena, pine needle oil, orange blossom oil, attar of roses and Jasmin oil.
This freshener also can be selected from least one of chemosynthesis composition, be specially and be selected from menthol, menthone, menthyl ester, Herba Menthae salt and amides compound, concrete can be 3-1-menthoxypropane-1, the 2-glycol, menthone glycerol ketals, menthyl lactate, menthyl acetate, the Herba Menthae alkyl formamides, acyclic Methanamide, the succinic acid menthyl ester, thin lotus alcohol radical succinate, the alkali metal salt of thin lotus alcohol radical succinate, L-Monomenthyl glutarate, single menthyl glutarate, free radical N-ethyl-P-terpane-3-carboxylic acid amides, trimethyl isopropyl butanamide, (1R, 2S, 5R)-N-ethyl-2-isopropyl-5-hexahydrotoluene Methanamide, (1R, 2S, 5R)-N-(4-(cyano methyl) phenyl)-2-isopropyl-5-hexahydrotoluene amide and (1R, 2S, 5R)-2-isopropyl-5-methyl-N-(2-(pyridine-2-isopropyl) ethyl) at least one in cyclohexane carboxamide.
The main barrier of skin restriction inside and outside material exchange comes from cuticular tight structure, short skin penetrating agent can reversibly change the arrangement configuration of lipid, the ability that sees through of intercellular channel is increased, thereby be conducive to pruritus and freshener, see through horny layer and play a role.And, when not re-using transdermal enhancer, cuticular permeability returns to normal again.The part transdermal enhancer can also give the surface property that paper is good simultaneously, makes paper surface become smoothly comfortable.
This transdermal enhancer is selected from Oleum menthae, Flos Matricariae chamomillae oil, menthol, isopropyl methyl phenol, 1, the 3-butanediol, two polypropylene glycols, propylene glycol, pentanediol, hexadecanol, ethanol, glycerol, dicaprylyl carbonate, caprylic/capric triglyceride, Palmic acid is monooctyl ester, isopropyl myristate (IPM), isopropyl palmitate (IPP), Jojoba oil (also being Jojoba oil), olive oil, mineral oil, Oleum Ricini, lanoline, hyaluronic acid, collagen protein, dimethyl sulfoxide, salicylic acid, resorcinol, allantoin, propolis, theophylline, the total alkaloids, Cortex Moutan extract, Radix Sophorae Flavescentis extract, Rhizoma Chuanxiong extract, Radix Angelicae Sinensis extract, opopanax is pure, at least one in Radix Hamamelidis Mollis extracting solution and Aloe extraction solution.
In addition, in this refrigerant antipruritic compositions the quality percentage composition of hydrophobic lipophilicity substance reach 60% and more than, preferably reach 70%～90%.Generally speaking, hydrophilic group mainly comprises carboxylic acid group, sulfonic group, sulfate, phosphate, amino, quaternary ammonium salt, ether, carboxyl, carboxylate, block polyether etc.; The hydrophobic group mainly comprises alkyl, halogen atom, phenyl ring, ester group etc.Be judged to be hydrophilic compounds if only contain hydrophilic group in material; Be judged to be lipophilic cpd if only contain the hydrophobic group in material; If certain material had both contained hydrophilic group, contain again the hydrophobic group, by HLB value (hydrophile-lipophile balance value), judge its hydrophilic or lipophilicity.Be judged to be lipophilic cpd when the HLB value is less than 10, if the HLB value is greater than at 10 o'clock, is judged to be hydrophilic compounds.
Above-named pruritus, freshener, transdermal enhancer are multiple, as long as meet the ratio range of above-mentioned pruritus, freshener, transdermal enhancer, and make the quality percentage composition of hydrophobic lipophilicity substance in this refrigerant antipruritic compositions reach 60% and above getting final product.
Understandable, in this refrigerant antipruritic compositions also alternative be added with antiseptic, with to this refrigerant antipruritic compositions each composition play sterilization, antiseptical effect, make each composition can play a role within the shelf-life always.This antiseptic is selected from least one in tea tree ethereal oil, methyl hydroxybenzoate, mud moor gold ethyl ester, propylparaben, hibitane, Kazon, potassium sorbate, sodium dehydroacetate, sodium benzoate, benzalkonium chloride, benzalkonium bromide, benzethonium chloride and poly hexamethylene biguanide.
Understandable, also optionally adding pH adjusting agent in this refrigerant antipruritic compositions, to take the pH value of adjusting refrigerant antipruritic compositions be 6.0～6.5, makes its pH value similar to the pH value of skin surface.This pH adjusting agent is selected from least one in citric acid, sorbic acid, tartaric acid, malic acid, phosphoric acid, acetic acid, adipic acid, hydrochloric acid, the rich acid of horse, sodium citrate, potassium citrate, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, sodium hydroxide, sodium hydrogen phosphate and potassium carbonate.
While in described refrigerant antipruritic compositions, containing antiseptic and pH adjusting agent, the mass ratio of described pruritus, freshener, transdermal enhancer, antiseptic and pH adjusting agent is 0.1～20:0.1～30:30～80:1～10:0.05～5.
Napkin of the present invention is that at least one surface that above-mentioned refrigerant antipruritic compositions is put on to paper makes.The coating weight of this refrigerant antipruritic compositions is 5%～30% of paper quality, is preferably 8%～20%.The applying method that this refrigerant antipruritic compositions directly puts on paper surface can adopt one or more the compound mode in spraying, printing, coating, applying glue.
In this refrigerant antipruritic compositions the quality percentage composition of hydrophobic lipophilicity substance reach 60% and more than.So, when being transferred to paper surface, this refrigerant antipruritic compositions can as the water solublity formula is transferred on paper, not be easy to diffusion, but form a plurality of points that contain compositions at paper surface, during paper wiping skin, the refrigerant antipruritic compositions on paper is easy to transfer on skin like this.
This paper can be monolayer, bilayer, or more multi-layered.This paper is preferably the tissue paper of low grammes per square metre, and basic weight is 10～80g/m
2, preferred basis weights is 10～40g/m
2.
Refrigerant antipruritic compositions of the present invention, by selecting pruritus, freshener and transdermal enhancer formulated according to specific ratio, plays good refrigerant itching-relieving efficacies.In addition, when transferring to paper surface, refrigerant antipruritic compositions of the present invention can as the water solublity formula is transferred on paper, not spread, but form a plurality of points spaced apart at paper surface, during paper wiping skin, the refrigerant antipruritic compositions on paper is easy to transfer on skin like this.
Below by specific embodiment, the present invention is described further.
The preparation of napkin in embodiment 1-3: the cellulose suspension that at first prepares low concentration, then this suspension is dewatered after by the forming net molding, form thin slice, will can obtain the monolayer paper for daily use thin slice of required drying after the thin slice drying, the basic weight of this single sheet is 10g/m2.Monolayer paper for daily use thin slice can carry out rewinding, obtains two-layer, three layers, more multi-layered paper for daily use.With coating method, refrigerant antipruritic compositions of the present invention is transferred on the tissue paper outer surface, institute's spray composition quality accounts for tissue paper mass percent 10%, can prepare the napkin that the present invention has refrigerant antipruritic function.
Embodiment 1
The refrigerant antipruritic compositions of the embodiment 1 ginseng table one of specifically filling a prescription.
Table one
Embodiment 2
The refrigerant antipruritic compositions of the embodiment 2 ginseng table two of specifically filling a prescription.
Table two
Embodiment 3
The refrigerant antipruritic compositions of the embodiment 3 ginseng table three of specifically filling a prescription.
Table three
Result of use test: will cause crowd 40 people of pruritus symptom due to mosquito bite, and be equally divided into four groups, every group of each 10 people.First group of napkin that uses embodiment 1, second group of napkin that uses embodiment 2, the 3rd group of napkin that uses embodiment 3, the 4th group is used common napkin.Three to five times, wiping every day pruritus position, wiping dynamics and frequency are accustomed to according to each one, with comfortable, are advisable, and use continuously 7 days.In use procedure, the people of first, second and third group obviously feels that there is refrigerant comfortable sensation at the pruritus position, and the 4th group of people do not have this sensation.After 7 days, people's pruritus symptom of first, second and third group disappears substantially, and is also substantially recovered by the damaged skin of mosquito bite; In the 4th group of people, have 60% above people to still have scratchiness, and skin recover do not have the people of first, second and third group fast.
In addition, those skilled in the art also can make various modifications, interpolation and the replacement on other form and details in the claims in the present invention scope of disclosure and spirit.Certainly, the variations such as various modifications, interpolation and replacement that these are made according to spirit of the present invention, within all should being included in the present invention's scope required for protection.
Claims (12)
1. a refrigerant antipruritic compositions, it is characterized in that: this refrigerant antipruritic compositions contains at least one pruritus, at least one freshener and at least one transdermal enhancer, and the mass ratio of wherein said pruritus, freshener, transdermal enhancer is 0.1～20:0.1～30:30～80; In this refrigerant antipruritic compositions the quality percentage composition of hydrophobic lipophilicity substance reach 60% and more than.
2. refrigerant antipruritic compositions as claimed in claim 1, it is characterized in that: the mass ratio of described pruritus, freshener, transdermal enhancer is 1～10:1～15:50～80.
3. refrigerant antipruritic compositions as claimed in claim 1, it is characterized in that: in this refrigerant antipruritic compositions, the quality percentage composition of hydrophobic lipophilicity substance reaches 70%～90%.
4. refrigerant antipruritic compositions as claimed in claim 1, it is characterized in that: this pruritus is selected from terpinenol-4, Artemisia alcohol, linalool, cineole, phellandrene, Bi Cheng adds alkene, thujanol, mequitazine, Cyproheptadine, doxepin, cimetidine, ichthyol, crotamiton, antol (Sumitomo), chlorphenamine maleate, dexbrompheniramine maleate, indomethacin, diphhydramine hydrochloride, dexamethasone, dexamethasone acetate, methylprednisolone acetate, the propanoic acid dexamethasone, dexamethasone acetate, prednisolone acetate, prednisolone valerate acetate, hydrocortisone acetate, triamcinolone acetonide acetate, Borneolum Syntheticum, Oleum Caryophylli, litsea cubeba oil, paeonol, Radix Sophorae Flavescentis extract, Fructus cnidii extract, Fructus Kochiae extract, Herba Schizonepetae extract, Radix Saposhnikoviae extract, Radix Scutellariae extract, Folium perillae extract, Folium Artemisiae Argyi extract, the Cortex cercis chinensis extract, Cortex Meliae extract, Rhizoma Bistortae extract, at least one in Alumen extract and Bulbus Allii extract.
5. refrigerant antipruritic compositions as claimed in claim 1, it is characterized in that: this freshener is selected from Fructus Piperis peppermint oil, oleum menthae viridis, Oleum menthae, Mentholum, Camphora, eucalyptus oil, chrysanthemum extract liquid, Borneolum Syntheticum, Rhizoma Picrorhizae extract, the Cortex Dictamni extract, Olibanum oil, parsley oil, Oleum Anisi Stellati, wintergreen oil, Oleum Cinnamomi, Fructus Citri Limoniae oil, orange peel oil, Cardamom oil, Fructus Coriandri oil, Pericarpium Citri Reticulatae oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, caraway seed oil, cassia oil, Indian oil of verbena, pine needle oil, orange blossom oil, attar of roses, Jasmin oil, menthol, menthone, menthyl ester, Herba Menthae salt and amides compound, 3-1-menthoxypropane-1, the 2-glycol, menthone glycerol ketals, menthyl lactate, menthyl acetate, the Herba Menthae alkyl formamides, acyclic Methanamide, the succinic acid menthyl ester, thin lotus alcohol radical succinate, the alkali metal salt of thin lotus alcohol radical succinate, L-Monomenthyl glutarate, single menthyl glutarate, free radical N-ethyl-P-terpane-3-carboxylic acid amides, trimethyl isopropyl butanamide, (1R, 2S, 5R)-N-ethyl-2-isopropyl-5-hexahydrotoluene Methanamide, (1R, 2S, 5R)-N-(4-(cyano methyl) phenyl)-2-isopropyl-5-hexahydrotoluene amide and (1R, 2S, 5R)-2-isopropyl-5-methyl-N-(2-(pyridine-2-isopropyl) ethyl) at least one in cyclohexane carboxamide.
6. refrigerant antipruritic compositions as claimed in claim 1, it is characterized in that: this transdermal enhancer is selected from Oleum menthae, Flos Matricariae chamomillae oil, menthol, isopropyl methyl phenol, 1, the 3-butanediol, two polypropylene glycols, propylene glycol, pentanediol, hexadecanol, ethanol, glycerol, dicaprylyl carbonate, caprylic/capric triglyceride, Palmic acid is monooctyl ester, isopropyl myristate, isopropyl palmitate, Jojoba oil, olive oil, mineral oil, Oleum Ricini, lanoline, hyaluronic acid, collagen protein, dimethyl sulfoxide, salicylic acid, resorcinol, allantoin, propolis, theophylline, the total alkaloids, Cortex Moutan extract, Radix Sophorae Flavescentis extract, Rhizoma Chuanxiong extract, Radix Angelicae Sinensis extract, opopanax is pure, at least one in Radix Hamamelidis Mollis extracting solution and Aloe extraction solution.
7. refrigerant antipruritic compositions as claimed in claim 1, is characterized in that: in this refrigerant antipruritic compositions, also contain at least one in antiseptic and pH adjusting agent.
8. refrigerant antipruritic compositions as claimed in claim 7, it is characterized in that: this antiseptic is selected from least one in tea tree ethereal oil, methyl hydroxybenzoate, mud moor gold ethyl ester, propylparaben, hibitane, Kazon, potassium sorbate, sodium dehydroacetate, sodium benzoate, benzalkonium chloride, benzalkonium bromide, benzethonium chloride and poly hexamethylene biguanide; It is 6.0～6.5 that this pH adjusting agent makes the pH value of this refrigerant antipruritic compositions, and this pH adjusting agent is selected from least one in citric acid, sorbic acid, tartaric acid, malic acid, phosphoric acid, acetic acid, adipic acid, hydrochloric acid, the rich acid of horse, sodium citrate, potassium citrate, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, sodium hydroxide, sodium hydrogen phosphate and potassium carbonate.
9. refrigerant antipruritic compositions as claimed in claim 7, it is characterized in that: while in described refrigerant antipruritic compositions, containing antiseptic and pH adjusting agent, the mass ratio of described pruritus, freshener, transdermal enhancer, antiseptic and pH adjusting agent is 0.1～20:0.1～30:30～80:1～10:0.05～5.
10. an application rights requires the napkin of the described refrigerant antipruritic compositions of any one in 1～9, and this refrigerant antipruritic compositions directly puts at least one surface of paper, and this refrigerant antipruritic compositions forms a plurality of points spaced apart at paper surface.
11. napkin as claimed in claim 10 is characterized in that: the coating weight of this refrigerant antipruritic compositions is paper quality 5%～30%.
12. napkin as claimed in claim 10 is characterized in that: the coating weight of this refrigerant antipruritic compositions is paper quality 8%～20%.
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| CN104000741A (en) * | 2014-04-25 | 2014-08-27 | 万强胜 | Externally applied solution for itching relieving and mosquito repelling |
| CN104250927A (en) * | 2014-06-09 | 2014-12-31 | 浙江纺织服装科技有限公司 | Wrinkle resistant and shrink proof mugwort microcapsule finishing agent for fabric and preparation method thereof |
| CN104274634A (en) * | 2014-08-14 | 2015-01-14 | 杭州方回春堂国药馆有限公司 | Compound plant essential oil for refreshing, restoring consciousness, diminishing swelling and relieving itching and preparation method of compound plant essential oil |
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| CN104721270A (en) * | 2013-12-20 | 2015-06-24 | 刘艳红 | Medicinal ointment and preparation method thereof |
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