CN110090190A

CN110090190A - A kind of baby child plant is releived refrigerant liquid and preparation method thereof

Info

Publication number: CN110090190A
Application number: CN201910427257.8A
Authority: CN
Inventors: 丘北泳; 黄飞燕; 胡永星
Original assignee: ZHONGSHAN AIHU COMMODITY CO Ltd
Current assignee: ZHONGSHAN AIHU COMMODITY CO Ltd
Priority date: 2019-05-22
Filing date: 2019-05-22
Publication date: 2019-08-06
Anticipated expiration: 2039-05-22
Also published as: CN110090190B

Abstract

It releives refrigerant liquid and preparation method thereof the invention discloses a kind of baby child plant.The baby child plant releive refrigerant liquid include following component by mass percentage: 1,3-propanediol 4-12%, butanediol 1-6%, oat kernel extract 1-5%, 1,2- pentanediol 2-8%, peppermint lactate 1-5%, CalmYang composite plant are releived essence 1-5%, beta glucan 0.5-2.5%, Blumea oil 0.1-0.6%, aloe barbadensis Miller powder 0.1-0.5%, dipotassium glycyrrhizinate 0.1-0.5%.The present invention utilizes 1 under a certain amount of, the permeability of 2- pentanediol specificity promotion oat kernel extract and CalmYang, there is good synergistic function between oat kernel extract and CalmYang plant extracts, effect ingredient used is plant origin, chemical preservative is not added, it is mildly non-stimulated while quickly capable of releiving antipruritic.

Description

A kind of baby child plant is releived refrigerant liquid and preparation method thereof

Technical field

It releives refrigerant liquid and preparation method thereof the present invention relates to skin care implement more particularly to a kind of baby child plant.

Background technique

Due to baby child's skin is thin, barrier function is weak, environmental stimuli resilience is weak etc., baby child is easy to skin occur The reaction such as itch, shouting pain, antipruritic refrigerant product of quickly releiving increasingly are welcome by mothers.

The antipruritic class product of releiving of current baby child's class on the market, mostly based on cream and aqua.The antipruritic effect of aqua class product Rate is most fast, therefore product is numerous, and in order to pursue Quick itch stopping in these products, medicinal hydrochloric acid diphenhydramine can be added in formula, Artificial synthesized menthol, borneol, alcohol etc. are used for a long time containing medicinal and chemical synthesis component product, can be easy to produce skin Raw dependence, certain damage is caused to baby child's skin.Also occur antipruritic refrigerant product of releiving with plant extracts on the market, Overall security improves, but since plant extract is not easy to be absorbed by the skin, this kind of products work slowly, antipruritic Effect is undesirable.

In conclusion antipruritic refrigerant aqua product of releiving on the market respectively has advantage and disadvantage at present.So exploitation uses peace Entirely, rapid-action baby child plant refrigerant liquid of releiving has important practical significance.

Summary of the invention

The primary purpose of the present invention is that the shortcomings that overcoming the prior art and insufficient, provide a kind of baby child plant releive it is refrigerant Liquid.

It is another object of the present invention to provide releived the preparation method of refrigerant liquid by above-mentioned baby child plant.

The purpose of the invention is achieved by the following technical solution:

A kind of baby child plant is releived refrigerant liquid, includes following component by mass percentage: 1,3-PD 4-12%, Butanediol 1-6%, oat kernel extract 1-5%, 1,2- pentanediol 2-8%, menthanol lactic acid ester 1-5%, CalmYang are compound Plant is releived essence 1-5%, beta glucan 0.5-2.5%, Blumea oil 0.1-0.6%, aloe barbadensis Miller powder 0.1-0.5%, sweet Oxalic acid dipotassium 0.1-0.5%.

The baby child plant refrigerant liquid of releiving also includes the substance with bacteria resistance function.

The substance with bacteria resistance function is preferably the substance that active constituent is mainly decoyl hydroximic acid, such as decoyl hydroxyl The pungent glycol & glycerol of oxime acid &, decoyl hydroximic acid & glycerol caprylate & methyl propanediol, decoyl hydroximic acid & glycerol caprylate & glycerol, Decoyl hydroximic acid & Sensiva SC50 & methyl propanediol, the pungent Gan Chun &1,3 propylene glycol of decoyl hydroximic acid & or decoyl hydroximic acid & 1,3 propylene glycol；More preferably decoyl Qiang Wosuan &1,3 propylene glycol (Zeastat).

The substance with bacteria resistance function is preferably quality hundred in the releive content of refrigerant liquid of the baby child plant Divide and compares 0.5-2%.

The baby child plant is releived refrigerant liquid, and following component by mass percentage: 1,3-PD is preferably included 6-10%, butanediol 2-4%, oat kernel extract 2-4%, 1,2- pentanediol 3-7%, menthanol lactic acid ester 2-4%, CalmYang composite plant is releived essence 2-4%, beta glucan 1-2%, Blumea oil 0.2-0.5%, aloe barbadensis Miller powder 0.2- 0.4%, dipotassium glycyrrhizinate 0.2-0.4%, Zeastat 0.8-1.6%；More preferably comprising it is following by mass percentage Component: 1,3- propylene glycol 6-8%, butanediol 3-3.5%, oat kernel extract 2-3%, 1,2- pentanediol 4-5%, menthol cream Acid esters 2-3%, CalmYang 2.2-3%, beta glucan 1.5-1.8%, Blumea oil 0.2-0.35%, aloe barbadensis Miller powder 0.25-0.3%, dipotassium glycyrrhizinate 0.2-0.3%, Zeastat 0.8-1.25%.

The baby child plant is releived refrigerant liquid, also includes water.

The amount of the water is surplus.Surplus refers to that the summation of water and other compositions is mass percent 100%.

Above-mentioned baby child plant is releived the preparation method of refrigerant liquid, is included the following steps:

(1) 1,3-PD, aloe barbadensis Miller powder and beta glucan are added to the water and stir to get uniform system, as A phase；

(2) releive essence, 1,2- pentanediol, menthanol lactic acid ester of oat kernel extract, CalmYang composite plant is stirred It mixes uniformly, obtains B phase；

(3) butanediol and Blumea oil are mixed to get transparency liquid, as C phase；When containing with bacteria resistance function substance When, it is that butanediol, Blumea oil and the material mixing with bacteria resistance function are obtained into transparency liquid, as C phase；

(4) first B is added in A phase, is sufficiently stirred after obtaining transparency liquid, add C phase and dipotassium glycyrrhizinate, mixed After the completion of conjunction, homogeneous is releived refrigerant liquid to get baby child plant.

Water described in step (1) is preferably deionized water.

The condition of homogeneous described in step (4) is preferred are as follows: homogeneous revolving speed is 2000r/min.

The time of homogeneous described in step (4) is preferably 1min.

The baby child plant is releived the preparation method of refrigerant liquid, and all entire process for preparation temperature are preferably controlled in 45 DEG C Below.The purpose is to reduce the destruction to plant extracts Ingredients Active.

The present invention has the following advantages and effects with respect to the prior art:

The refrigerant liquid 1. baby child plant of the invention is releived, does not add chemical preservative, alcohol-free, with plant releive essence at Point substituting medicinal or chemical synthesis releives antipruritic, improves the safety for refrigerant liquid of releiving, reduces and generate irritating risk.

Refrigerant effect ingredient oat kernel extract used, menthanol lactic acid ester, product 2. baby child plant of the invention is releived Careless extract, german chamomile flower extract, glycyrrhiza glabra root extract, tea extract, polygonum cuspidate root extract, rosemary leave is avenged to extract Object, radix scutellariae root extract, glucan, Aloe Barbadensis Miller powder, dipotassium glycyrrhizinate, are plant origin, mild non-stimulated.

The refrigerant liquid 3. baby child plant of the invention is releived can increase skin permeation using 1, the 2- pentanediol under a certain amount of Property principle so that the plant of formula is releived, essential ingredient obtains good bioavilability, the essence so that plant is releived Ingredient can rapidly enter skin, antipruritic effect of quickly being releived, hence it is evident that improve that be applied alone plant extracts to releive antipruritic The status of low efficiency.

Detailed description of the invention

Fig. 1 is the bioavilability result figure of HPLC-UV quantitative analysis embodiment 1 and each observation index of comparative example 1-4.

Specific embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment and attached drawing, but art technology Personnel will be understood that following embodiments and embodiment are merely to illustrate the present invention, and are not construed as limiting the scope of the invention. The person that is not specified actual conditions, carries out according to conventional conditions or manufacturer's recommended conditions.Production is not specified in agents useful for same or instrument Manufacturer person is the conventional products that can be obtained by commercially available purchase.

Embodiment of the present invention provide baby child plant releive refrigerant liquid formula in:

Oat kernel extract: the oat acyl group anthranilic acid in oat can provide provisional protection for skin, and delay Solution small pain and itch as caused by poison ivy, poison oak, black poison wood and bite by mosquitos, also can be relieved dry skin Caused itch.The oat kernel extract that the embodiment of the present invention uses comes from the fragrant company of moral.

CalmYang: by Gotu Kola P.E, polygonum cuspidate root extract, scutellariae,radix extraction, tea extract, glycyrrhiza glabra root Extract, rosemary leaf extract, german chamomile flower extract composition, the work with anti-oxidant, anti-inflammatory, allergy of releiving, Lavender Extract With.The CalmYang that the embodiment of the present invention uses comes from hundred Ou Site company, South Korea.

Beta glucan: the effective component lifted from mushroom (schizophyllum commune) can promote wound healing, moisturizing, sunburn to repair Again, the features such as collagen synthesis, cell Proliferation, immunological regulation.The beta glucan that the embodiment of the present invention uses is good rich from hundred Company.

Aloe Barbadensis Miller powder: fresh pure plant extraction, mild pure, can releive the common heat flush of baby's skin.This The Aloe Barbadensis Miller powder that inventive embodiments use comes from Guangzhou Wan Lu Chemical Co., Ltd..

Dipotassium glycyrrhizinate: extracting the effective component in Radix Glycyrrhizae, has antiallergy, anti-inflammatory effect.The embodiment of the present invention uses Dipotassium glycyrrhizinate come from Mai Fu company.

1,2- pentanediol: the moisturizer haveing excellent performance, while there is antisepsis, the product of preservative free can be prepared, is subtracted Allergy caused by few preservative.1.2- pentanediol effect of the present invention is anti-corrosion synergy, promotes infiltration.What the embodiment of the present invention used 1.2- pentanediol comes from the fragrant company of moral.

Zeastat: it is that preservative free cosmetics and personal care product design that decoyl Qiang Wosuan &1,3 propylene glycol, which are a kind of, The protective system of exploitation has good moisture-keeping function, while having bacteriostasis efficacy, it is ensured that system is not adding preservative Under conditions of, it suppresses growth of microorganism, guarantees product quality.The Zeastat that the embodiment of the present invention uses comes from U.S. Ying Dishi Company.

Embodiment 1

(1) 6%1,3- propylene glycol, 0.25% aloe barbadensis Miller powder and 1.8% beta glucan are added to the water and are stirred to get Uniform system, as A phase.

(2) 2% oat kernel extract, 2.2%CalmYang, 5%1,2- pentanediol and 2% peppermint lactate are stirred equal It is even, obtain B phase.

(3) 3% butanediol, 0.8%Zeastat and 0.2% Blumea oil are mixed, obtained transparency liquid is as C phase.

(4) first B is added in A phase, after obtaining transparency liquid after being sufficiently stirred, adds C phase and 0.2% glycyrrhizic acid After the completion of dipotassium mixing, finally releived refrigerant liquid with the revolving speed homogeneous of 2000r/min one minute to get baby child plant.

In order to reduce the destruction to plant extracts Ingredients Active, all entire process for preparation temperature to control 45 DEG C with Under.

Embodiment 2

(1) 8%1,3- propylene glycol, 0.3% aloe barbadensis Miller powder and 1.5% beta glucan are added to the water and are stirred to get One system, as A phase.

(2) 3% oat kernel extract, 3%CalmYang, 4%1,2- pentanediol and 3% peppermint lactate are stirred equal It is even, obtain B phase.

(3) 3.5% butanediol, 1.25%Zeastat and 0.35% Blumea oil are mixed, obtained transparency liquid is as C Phase.

(4) first B is added in A phase, after obtaining transparency liquid after being sufficiently stirred, adds C phase and 0.3% glycyrrhizic acid After the completion of dipotassium mixing, finally releived refrigerant liquid with the revolving speed homogeneous of 2000r/min one minute to get baby child plant.

Comparative example 1

(2) 2% oat kernel extract, 2.2%CalmYang and 2% peppermint lactate are stirred evenly, obtains B phase.

Comparative example 2

(2) 2% oat kernel extract, 2.2%CalmYang, 5%1,2- hexylene glycol and 2% peppermint lactate are stirred equal It is even, obtain B phase.

(3) 3% butanediol, 0.8%Zeastat (decoyl hydroximic acid) and 0.2% Blumea oil are mixed, obtained transparent liquid Body is as C phase.

Comparative example 3

(2) 2% oat kernel extract, 2.2%CalmYang, 10% water-solubleazone and 2% peppermint lactate are stirred Uniformly, B phase is obtained.

Comparative example 4

(2) 2% bagodryl hydrochloride and 2% peppermint lactate are stirred evenly, obtains B phase.

Comparative example 5

(2) 2% oat kernel extract, 5%1,2- pentanediol and 2% peppermint lactate are stirred evenly, obtains B phase.

Comparative example 6

(2) 2.2%CalmYang, 5%1,2- pentanediol and 2% peppermint lactate are stirred evenly, obtains B phase.

Effect example

1. bioavilability is tested: evaluation embodiment 1 and comparative example 1-4 are formulated the permeability to skin

Experimental material: 4cm is made in vitro wistar big white mouse mouse skin²The skin graft of size, with normal saline flushing it is clean after It puts in -20 DEG C of refrigerator and saves, mouse skin, the invisible any breakage of naked eyes are detected before testing.

Experimental method: using improvement Franz diffuser casing, diffusion area 2.45cm², the stirring of 150r/min constant speed.It will place The mouse skin managed is fixed between the supply pool of diffusion cell and reception tank, and towards supply pool, supply pool is added to be implemented stratum corneum side Distilled water is added in example or comparative example 3ml, reception tank.37 ± 1 DEG C of bath temperature, respectively at 10min, 30min, 100min essence Close absorption acceptable solution 10ml supplements 10ml physiological saline in beaker immediately.Again by receiving liquid micro-pore-film filtration, use HPLC-UV quantitative analysis embodiment 1 and comparative example 1-3HPLC-UV observation index oat kernel extract and CalmYang summation, point Analyse comparative example 4HPLC-UV observation index bagodryl hydrochloride (note: itself has excellent permeability).

Test result: as seen in Figure 1, embodiment 1 and 4 bioavilability of comparative example are relatively comparisons Example 4 substitutes pentanediol oat kernel extract and CalmYang with chemical synthesis antipruritic bagodryl hydrochloride, thus illustrates reality Applying the bagodryl hydrochloride of the permeability of oat kernel extract and CalmYang and comparative example 4 in 1 is relatively.

For embodiment 1 compared with comparative example 1, comparative example 1 is free of 1,2- pentanediol, and bioavilability obviously differs several multiples More than, thus illustrating 1,2- pentanediol has the infiltrative effect for promoting oat kernel extract and CalmYang.

For embodiment 1 compared with comparative example 2, comparative example 2 substitutes 1,2- pentanediol, but comparative example 2 using 1,2- hexylene glycol Bioavilability be it is relatively low, illustrate that other polyalcohols promote osmotic effect unknown oat kernel extract and CalmYang It is aobvious.

Embodiment 1 compared with comparative example 3, comparative example 3 be with skin penetrant water-solubleazone substitute 1,2- pentanediol, but The bioavilability of comparative example 3 or relatively low illustrates that skin penetrant promotes oat kernel extract and CalmYang Osmotic effect is unobvious.

In summary: under the premise of 1,2- pentanediol is existing, the permeability and change of oat kernel extract and CalmYang It is more similar to learn synthesis antipruritic bagodryl hydrochloride.1,2- pentanediol have uniqueness effectively facilitate oat kernel extract and The permeability of CalmYang.

2. security test

Test method: the skin irritation of foundation Ministry of Health of the People's Republic of China " cosmetics health specification " 2007 editions/ Corrosion test method, and the common grade new zealand rabbit for taking quarantine qualified (male and female each two, by Guangdong Province medical experiment animal The heart three provides water basely) it is directly used in skin irritation test.Experimental animal back backbone two sides coat is cut before test, is gone Hair range is left and right Ge Yue 3cm × 3cm.The baby that Example or comparative example the are prepared refrigerant liquid about 0.5g that releives is applied to On the left of animal on skin, application area about 2.5cm × 2.5cm is smeared once daily, and continuous to smear 14 days, blank is made in the other side Control.Since second day, cropping before smearing daily removed residual baby with pure water and releives refrigerant liquid, and check plot is made same It handles, observes result after 1h after smearing.

1 skin irritatin strength grading of table

Integral mean value	Intensity
		0~< 0.5	It is nonirritant
0.5~< 2.0	Subexcite
		2.0~< 6.0	Moderate stimulation
6.0~8.0	Strong and stimulating

The multiple skin irritation test result of 2 new zealand rabbit of table

Sample	Embodiment 1	Embodiment 2	Comparative example 3	Comparative example 4
					Daily every animal integral mean value	0	0.12	0.93	0.45

Above data (Tables 1 and 2) is tested by Bao Hua inspection center, Guangdong Province and is provided.

Test result shows that, according to skin irritatin strength grading standard, embodiment 1, embodiment 2 and comparative example 4 are prepared into To refrigerant liquid of releiving it is nonirritant, embodiment 1 and embodiment 2 are better than the comparative example 4 with chemical synthesis antipruritic in data, Illustrate to be slightly better than useization with the arrange in pairs or groups plant refrigerant liquid safety of releiving of oat kernel extract and CalmYang of 1,2- pentanediol Learn the refrigerant liquid of releiving of antipruritic bagodryl hydrochloride.

Comparative example 3 is prepared refrigerant liquid of releiving and uses 1,2- pentanediol with subexcite, embodiment 1 and embodiment 2 As permeation enhancers, it is seen that the safety of 1,2- pentanediol, which is significantly better than, uses skin penetrant water-solubleazone.

3. both effectiveness test

100 volunteers (mother and baby) are chosen, in 2 months to during October, changing embodiment sample every two months, every two The embodiment efficacy assessments statistical collection of progress in a month.

Table 3 is releived antipruritic refrigerant liquid efficacy assessments result

Both effectiveness test result: as can be seen from Table 3, embodiment 1 and embodiment 2 and comparative example 4 are releived the antipruritic time With antipruritic effect evaluation of releiving, data differences are unobvious, illustrate arranged in pairs or groups with pentanediol oat kernel extract and CalmYang plant It releives refrigerant liquid made from object extract and refrigerant liquid of releiving made from bagodryl hydrochloride releiving on antipruritic effect is very Close.In use process test whether excitatory, with plant releive essence embodiment 1 and embodiment 2 is made will be slightly Better than the comparative example 4 made from chemical synthesis antipruritic.

Comparative example 1 is with comparative example 5 and comparative example 6, it can be seen that comparative example 5 (scarce CalmYang) is with comparative example 6 (lack oat kernel extract) releives antipruritic effect far away from embodiment 1 to skin due to lacking a component in composition of raw materials, To which explanation is in the case where 5% 1,2 pentanediols promote infiltration, have between oat kernel extract and CalmYang plant extracts good Synergistic function.

The preferred embodiments of the disclosure and embodiment are explained in detail above, but the present invention is not limited to The above-described embodiment and examples can also not depart from the present invention in the knowledge category that those skilled in the art have Various changes can be made under the premise of design.

Claims

The refrigerant liquid 1. a kind of baby child plant is releived, it is characterised in that: include following component by mass percentage: 1,3- the third two Alcohol 4-12%, butanediol 1-6%, oat kernel extract 1-5%, 1,2- pentanediol 2-8%, peppermint lactate 1-5%, CalmYang composite plant is releived essence 1-5%, beta glucan 0.5-2.5%, Blumea oil 0.1-0.6%, aloe barbadensis Miller powder 0.1-0.5%, dipotassium glycyrrhizinate 0.1-0.5%.
The refrigerant liquid 2. baby child plant according to claim 1 is releived, it is characterised in that: the baby child plant is releived refrigerant Liquid also includes the substance with bacteria resistance function.
The refrigerant liquid 3. baby child plant according to claim 2 is releived, it is characterised in that: the object with bacteria resistance function Matter is the pungent glycol & glycerol of decoyl hydroximic acid &, decoyl hydroximic acid & glycerol caprylate & methyl propanediol, decoyl hydroximic acid & caprylic Acid esters & glycerol, decoyl hydroximic acid & Sensiva SC50 & methyl propanediol, the pungent Gan Chun &1,3 propylene glycol or pungent of decoyl hydroximic acid & At least one of acyl Qiang Wosuan &1,3 propylene glycol.
The refrigerant liquid 4. baby child plant according to claim 2 is releived, it is characterised in that: the object with bacteria resistance function Matter the baby child plant releive refrigerant liquid content be mass percent 0.5-2%.
The refrigerant liquid 5. baby child plant according to any one of claims 1 to 4 is releived, it is characterised in that: comprising pressing matter below Measure the component of percentages: 1,3- propylene glycol 6-10%, butanediol 2-4%, oat kernel extract 2-4%, 1,2- pentanediol 3- 7%, peppermint lactate 2-4%, CalmYang composite plant is releived essence 2-4%, beta glucan 1-2%, Zeastat0.8- 1.6%, Blumea oil 0.2-0.5%, aloe barbadensis Miller powder 0.2-0.4%, dipotassium glycyrrhizinate 0.2-0.4%.
The refrigerant liquid 6. baby child plant according to claim 5 is releived, it is characterised in that: comprising it is following by mass percentage Component: 1,3- propylene glycol 6-8%, butanediol 3-3.5%, oat kernel extract 2-3%, 1,2- pentanediol 4-5%, menthol Lactate 2-3%, CalmYang 2.2-3%, beta glucan 1.5-1.8%, Blumea oil 0.2-0.35%, aloe barbadensis Miller powder 0.25-0.3%, dipotassium glycyrrhizinate 0.2-0.3%, Zeastat 0.8-1.25%.
The refrigerant liquid 7. baby child plant according to any one of claims 1 to 4 is releived, it is characterised in that: the baby Tong Zhi Object is releived refrigerant liquid, also includes water, and the amount of the water is surplus.
The preparation method of refrigerant liquid 8. the described in any item baby child plants of claim 1~7 are releived, it is characterised in that: including such as Lower step:

(1) 1,3-PD, aloe barbadensis Miller powder and beta glucan are added to the water and stir to get uniform system, as A phase；

(2) releive essence, 1,2- pentanediol, peppermint lactate of oat kernel extract, CalmYang composite plant is stirred evenly, Obtain B phase；

(3) butanediol and Blumea oil are mixed to get transparency liquid, as C phase；When containing the substance with bacteria resistance function, it is Butanediol, Blumea oil and the material mixing with bacteria resistance function are obtained into transparency liquid, as C phase；

(4) first B is added in A phase, is sufficiently stirred after obtaining transparency liquid, added C phase and dipotassium glycyrrhizinate, mixed Cheng Hou, homogeneous are releived refrigerant liquid to get baby child plant.
The preparation method of refrigerant liquid 9. baby child plant according to claim 8 is releived, it is characterised in that: institute in step (4) The processing condition stated are as follows: homogeneous revolving speed is 2000r/min；The time of the homogeneous is 1min.
The preparation method of refrigerant liquid 10. baby child plant according to claim 8 is releived, it is characterised in that: all entirely to match Process temperature control processed is at 45 DEG C or less.