CN106377463A - Hydrating toner composition free from preservatives - Google Patents
Hydrating toner composition free from preservatives Download PDFInfo
- Publication number
- CN106377463A CN106377463A CN201611000547.7A CN201611000547A CN106377463A CN 106377463 A CN106377463 A CN 106377463A CN 201611000547 A CN201611000547 A CN 201611000547A CN 106377463 A CN106377463 A CN 106377463A
- Authority
- CN
- China
- Prior art keywords
- plant
- preservative
- hydrating
- water
- preservatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention discloses a hydrating toner composition free from preservatives. The hydrating toner composition free from the preservatives is prepared from the following components in percentage by weight: 0.05 to 10 percent of plant extract, 1 to 20 percent of humectant, 0.1 to 5 percent of caprylyl glycol, 0.1 to 5 percent of isooctyl glycerinum, and the balance of deionized water to achieve 100 percent. The hydrating toner composition is free from any preservative specified by Cosmetic Safety Technology Specification (Year of 2015). Prepared hydrating toner does not use traditional preservatives but adopts an inherent anti-bacterial function of common raw materials of cosmetics to cooperate with plant antibiotic constituents, so as to achieve an antiseptic aim through a synergistic effect, and overcomes the defects of irritation and safety brought by the traditional preservatives.
Description
Technical field
The present invention relates to a kind of moisturizing cosmetic water, specifically, it is a kind of moisturizing skin smoothing water composition without preservative,
Belong to cosmetic field.
Background technology
The use of cosmetics has a long history, now constantly carrying with expanding economy and people's living standard
Height, cosmetics have become an indispensable part in people's daily life.The cosmetics great majority of mankind's early application are all
Natural mineral matter, these materials inherently have the ability of antibacterial, there is not Anticorrosion.With social progress, science and technology
Development, former, the adjuvant of cosmetics are no longer limited to natural materials, but with the addition of various nutrient substance, cosmetics
In abundant nutritional labeling be easily subject to microorganism pollution, in addition the extraneous factor such as production equipment, packaging, storage also results in product
Product microorganism pollution, in order that cosmetics do not occur microorganism pollution within the shelf-life and in consumer's validity period, rationally prolongs
The long products shelf-life, various cosmetics must add certain preservative to prevent cosmetics from deterioration.
The cosmetics preservative of regulation definition is it is simply that refer to add in cosmetics to suppress microorganism to grow in this cosmetics
For the purpose of material.《Cosmetics safety technical specification》(2015)Defining preservative used in cosmetics must be this specification
In listed material, the meeting that these cosmetics preservatives using at present have produces stimulations, allergy etc. to skin and reacts, have to ring
Border has than larger harm.In recent years, state food drug regulatory department proposes increasingly to the safety of cosmetics
High requirement, safe and non-stimulating cosmetics progressively become focus of concern, and the safety of Preservative Technology for Personal Care is always
Enjoy query.With the raising of living standards of the people, for cosmetic allergic contact dermatitis problem pay attention to day by day.In order to comply with the consumption of the people
Demand, the research for the cosmetics without preservative has become as focus.
Content of the invention
The present invention is directed to the weak point of existing preservative, provides a kind of moisturizing skin smoothing water composition without preservative.
For achieving the above object, the present invention adopts the following technical scheme that:
A kind of moisturizing skin smoothing water composition without preservative is it is characterised in that include following components in percentage by weight:Plant
Extract 0.05~10%;Wetting agent 1~20%;Caprylyl glycol 0.1~5%;Iso-octyl glycerol 0.1~5%;Deionized water adds to
100%.
Preferably, a kind of described moisturizing skin smoothing water composition without preservative is it is characterised in that include following weight hundred
Divide the component of ratio:Vegetable composition extract 0.1~8%;Wetting agent 3~10%;Caprylyl glycol 0.1~3%;Iso-octyl glycerol 0.1~
3%;Deionized water adds to 100%.
Preferably, a kind of described moisturizing skin smoothing water composition without preservative is it is characterised in that include following weight hundred
Divide the component of ratio:Plant extract 0.5~6%;Wetting agent 4~8%;Caprylyl glycol 0.2~2%;Iso-octyl glycerol 0.2~2.5%;Go
Ionized water adds to 100%.
Preferably, a kind of described moisturizing skin smoothing water composition without preservative is it is characterised in that include following weight hundred
Divide the component of ratio:Vegetable composition extract 1~5%;Wetting agent 4~8%;Caprylyl glycol 0.3~2%;Iso-octyl glycerol 0.3~2%;
Deionized water adds to 100%.
Wherein said wetting agent is glycerol, 1,3- propylene glycol, 1,2- pentanediol, butanediol, Xylitol-based glucoside, wood
The compositionss of the three kinds or more in sugar alcohol, anhydro xylitol, biological carbohydrate gum -1, hyaluronate sodium, glucosan.
Wherein said plant extract is to make Folium olive 30-50 part, Cynara scolymus L (Cyhara cardunculus.) 20-45 by the plant of following parts by weight
Part, Pericarpium Granati 20-45 part, Radix Glycyrrhizae 15-30 part.Preparation method is as follows:Plant is pulverized, is sieved with 20~100 mesh sieve respectively,
Mixing, is 5 by liquid material mass ratio:1~20:1 addition Extraction solvent, after soaking 1~5h, extracts in 10~100MPa and uses under pressure
High pressure homogenization method machine carries out extract at room temperature, after extracting solution is centrifuged, with membrance concentration, concentrated solution macroporous resin adsorption,
The multiple eluting of ethanol being 10~95% with volume fraction again, collects eluent, the mass ratio of membrance concentration to extracting solution and plant amedica
For 1:0.1~1:5, add butanediol dissolving, filter, prepared plant drug composition;Extraction solvent is water, ethanol or ethanol water
Solution.
In addition to containing above composition, can also interpolation in a kind of described moisturizing skin smoothing water composition without preservative
Cosmetic commonly uses composition, such as the composition such as antioxidant, emollient, surfactant, essence.
A kind of moisturizing skin smoothing water composition without preservative of the present invention does not contain《Cosmetics safety technology is advised
Model》(2015)Any preservative of defined.
The moisturizing cosmetic water of the present invention is prepared from using industry universal method, for example, wetting agent is added deionized water
In, heated and stirred to mix homogeneously, it is separately added into plant extract and other heat-sensitive ingredients after cooling again, stir
This moisturizing cosmetic water is obtained.Obviously, preparation method adopts known technology, is not the innovation of the present invention.
Compared with prior art, the invention has the beneficial effects as follows:Do not use traditional preservatives, but commonly used using cosmetics
The intrinsic antibacterial functions cooperation plants antimicrobial composition of raw material, synergism reaches anti-corrosion purpose.Overcome traditional preservatives to bring
Zest and security flaw.
Plant extract, in addition to having antibiotic effect, also has the effects such as free radical resisting, antiallergic, irritation, specifically such as
Under:
Olive leaf P.E mainly contains secoiridoid and its glycosides, flavone and its glycosides, bisflavone and its glycosides, low molecule tannin etc.
Composition, has good broad-spectrum antibacterial action, also has functions that good antioxidation simultaneously and repairs skin injury.
Scolymus extract mainly contains abundant vitamin, flavone compound and liposoluble ingredient, has wider resisting
Bacterium property, can assist irritation, promote to ooze sterilization;And there is mitigation to the skin allergy leading to due to excessive histamine release and eliminate
Effect.
Pericarpium Granati extract mainly contains multiple alkaloids, bacteriostatic test confirmation, the alcohol extract of Punica granatum L. and peel decocting
Agent, has broad-spectrum antibacterial action and skin contraction effect.
Radix Glycyrrhizae extract mainly contains glycyrrhizin, glycyrrhizic acid, and liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, thorn awns handle
Florigen, Quercetin etc., have extraordinary heat-clearing and toxic substances removing, whitening and speckle dispelling, antioxidation and uvioresistant effect.
Specific embodiment
In order to preferably illustrate present invention, illustrated with some preferably specific embodiments below.But these tools
Body embodiment is simply to illustrate that present disclosure, rather than present invention is limited.
Embodiment 1
A kind of moisturizing skin smoothing water composition without preservative, is made up of the parts by weight component in formula as below table, is shown in Table 1.
Table 1
Preparation method:At room temperature, hyaluronate sodium is disperseed in glycerol and 1,3-PD in advance, be dissolved into deionized water
In after, be separately added into other compositions, be evenly stirred until and be completely dissolved, 200 mesh screen, discharging.
Comparative example 1
Commonly use protective system containing cosmetic water(Methyl parahydroxybenzoate, propyl p-hydroxybenzoate, phenoxyethanol)Moisturizing
Skin smoothing water composition, formula is shown in Table 1.
Embodiment 2-3
A kind of moisturizing skin smoothing water composition without preservative, is made up of the parts by weight component in formula as below table, is shown in Table 2 institutes
Show.
Table 2
Preparation method:At room temperature, hyaluronate sodium is disperseed in glycerol and 1,3-PD in advance, be dissolved into deionized water
In after, be separately added into other compositions, be evenly stirred until and be completely dissolved, 200 mesh screen, discharging.
Test example 1 moistening effect functional evaluation
According to light industry standard QB/T 4256-2011 cosmetics moisture-keeping efficacy evaluation guide, measure embodiment 1 and comparative example 1
The moistening effect of the moisturizing cosmetic water prepared respectively.
1st, experimental principle:It is based on water and other materials using the moisture that capacitance method measures human skin keratinocyte's layer
Difference in dielectric constant is notable, and according to the difference of keratodermatitis moisture, the capacitance of the skin recording is different, and its parameter can
Represent skin moisture content.
2nd, experimental apparatus:Comermeter CM825(German Courage+Khazaha company
3rd, experimental technique:Healthy volunteer 30, male 20, women 10, the age is in 25-50 year.In isoperibol(20~
22℃), relative humidity 50 ± 10%, after 1 hour of rest.It is respectively adopted embodiment 1, the sample of comparative example 1, press(2.0±
0.1)Mg/ 2 consumption is coated in experimenter's left hand inner forearm(3cm×3cm)Inside right forearm(3cm×3cm).Blank
(Do not apply)Test simultaneously.It is being painted with 1 hour of sample, 2 hours, 4 hours, the degree of hydration state of 6 hours test skin respectively.
4th, experimental result:It is shown in Table 3.
Table 3
Result shows, the moisturizing cosmetic water of the present invention has good moistening effect, and better than comparative example moistening effect.
Test example 2 preservation challenge is tested
With the moisturizing cosmetic water of system described in embodiment 1, common mixed cell in the work of single inoculation cosmetics(Golden yellow Fructus Vitis viniferae
Coccus SA, escherichia coli EC, Pseudomonas aeruginosa PA), mixed fungus(Aspergillus niger AN, white vacation screw mandrel bacterium CA), according to change
Cosmetic, toilet articles and fragrance association(CTFA)Microbial Challenge test method, the sample monitoring cycle is 28 days, and period is respectively
Carry out sample detection at the 2nd, 7,14 and 28 days, calculate the clump count of every mL(cfu).Result is as shown in table 4
Table 4 bacteriostatic experiment result
Strain | 0 day | 7 days | 14 days | 21 days | 28 days |
Mixed cell | 3×107 | 0 | 0 | 0 | 0 |
Mixed fungus | 5×105 | 0 | 0 | 0 | 0 |
Table 4 result shows, with the moisturizing cosmetic water obtaining described in embodiment 1, can pass through preservation challenge, fully achieve anti-corrosion
Effect.The growth of antibacterial and funguses can effectively be suppressed, so, the moisturizing cosmetic water of the present invention also has good anti-inflammation and makees
With.
Test example 3 patch is tested
With the moisturizing cosmetic water of system described in embodiment 1 and comparative example 1, carry out patch test and test its anaphylaxis to skin,
Method is:Try device from qualified speckle, sample uniform application is tried in device in speckle, then spread on the back of experimenter, gently pressed with palm
Be allowed to uniformly docile and obedient with skin on, continue 72h.It is spaced 30min after removing tested material speckle examination device, after impression disappears, observe skin
Reaction.Reference《Cosmetics safety technical specification》(Version in 2015)Middle dermoreaction grade scale record reaction result.Negative right
According to:Deionized water.Experimenter totally 30 people, male 20, women 10.Face test result on probation is as shown in table 5.
Table 5
Phenomenon | Skin pruritus | Skin irritation | Red swelling of the skin | Skin generates heat | Other untoward reaction | Amount to |
Comparative example 1 | 1 | 1 | 0 | 0 | 0 | 2 |
Embodiment 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Table 5 result shows, with the moisturizing cosmetic water of system described in embodiment 1, any allergic phenomena and not in trier
Good reaction.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not subject to above-described embodiment
Limit, other any spirit without departing from the present invention and the change made under principle, modification, replacement, combine, simplify,
All should be equivalent replacement mode, be included within protection scope of the present invention.
Claims (4)
1. a kind of moisturizing skin smoothing water composition without preservative is it is characterised in that include following components in percentage by weight:Plant
Thing extract 0.05~10%;Wetting agent 1~20%;Caprylyl glycol 0.1~5%;Iso-octyl glycerol 0.1~5%;Deionized water adds to
100%;A kind of described moisturizing skin smoothing water composition without preservative does not contain《Cosmetics safety technical specification》(2015)
Any preservative of defined.
2. the wetting agent described in claim 1 is glycerol, 1,3- propylene glycol, 1,2- pentanediol, butanediol, Xylitol-based glucose
The compositionss of the three kinds or more in glycosides, xylitol, anhydro xylitol, biological carbohydrate gum -1, hyaluronate sodium, glucosan.
3. the plant extract described in claim 1 is to make Folium olive 30-50 part, Cynara scolymus L (Cyhara cardunculus.) by the plant of following parts by weight
20-45 part, Pericarpium Granati 20-45 part, Radix Glycyrrhizae 15-30 part.
4. preparation method is as follows:Plant is pulverized, is sieved with 20~100 mesh sieve respectively, mixing, be 5 by liquid material mass ratio:1
~20:1 addition Extraction solvent, after soaking 1~5h, extracts in 10~100MPa and carries out room temperature with high pressure homogenization method machine under pressure
Extract, after extracting solution is centrifuged, with membrance concentration, concentrated solution macroporous resin adsorption, then be 10~95% with volume fraction
The multiple eluting of ethanol, collects eluent, and membrance concentration to extracting solution is 1 with the mass ratio of plant amedica:0.1~1:5, add fourth two
Alcohol dissolves, and filters, prepared plant drug composition;Extraction solvent is water, ethanol or ethanol water.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611000547.7A CN106377463A (en) | 2016-11-14 | 2016-11-14 | Hydrating toner composition free from preservatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611000547.7A CN106377463A (en) | 2016-11-14 | 2016-11-14 | Hydrating toner composition free from preservatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106377463A true CN106377463A (en) | 2017-02-08 |
Family
ID=57958553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611000547.7A Pending CN106377463A (en) | 2016-11-14 | 2016-11-14 | Hydrating toner composition free from preservatives |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106377463A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106860101A (en) * | 2017-02-23 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment nti-freckle toner |
CN106860154A (en) * | 2017-02-23 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment nti-freckle toner |
CN107582425A (en) * | 2017-10-19 | 2018-01-16 | 丹东欣时代生物医药科技有限公司 | A kind of anti-fog haze surfactant and preparation method thereof |
CN113304085A (en) * | 2021-07-15 | 2021-08-27 | 浙江明洋生命科技有限公司 | Application of plant extract in preparation of cosmetics with antibacterial and mite-killing functions |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011505353A (en) * | 2007-11-30 | 2011-02-24 | 株式會社アモーレパシフィック | Skin external preparation composition containing a compound herbal extract as an active ingredient |
CN103432047A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Natural preservative composition and application thereof in cosmetics |
CN105963151A (en) * | 2016-05-14 | 2016-09-28 | 广东轻工职业技术学院 | No-preservative composite used for cosmetics corrosion prevention |
-
2016
- 2016-11-14 CN CN201611000547.7A patent/CN106377463A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011505353A (en) * | 2007-11-30 | 2011-02-24 | 株式會社アモーレパシフィック | Skin external preparation composition containing a compound herbal extract as an active ingredient |
CN103432047A (en) * | 2013-09-12 | 2013-12-11 | 广东轻工职业技术学院 | Natural preservative composition and application thereof in cosmetics |
CN105963151A (en) * | 2016-05-14 | 2016-09-28 | 广东轻工职业技术学院 | No-preservative composite used for cosmetics corrosion prevention |
Non-Patent Citations (3)
Title |
---|
中华人民共和国卫生部: "《化妆品管理及安全性和功效性评价》", 31 January 2007 * |
刘军红,等: "生物碱提取、分离和纯化的研究进展", 《时珍国医国药》 * |
安徽医学院: "《中毒急救手册》", 28 February 1978, 上海科学技术出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106860101A (en) * | 2017-02-23 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment nti-freckle toner |
CN106860154A (en) * | 2017-02-23 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment nti-freckle toner |
CN107582425A (en) * | 2017-10-19 | 2018-01-16 | 丹东欣时代生物医药科技有限公司 | A kind of anti-fog haze surfactant and preparation method thereof |
CN113304085A (en) * | 2021-07-15 | 2021-08-27 | 浙江明洋生命科技有限公司 | Application of plant extract in preparation of cosmetics with antibacterial and mite-killing functions |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101374093B1 (en) | The functional beauti-pacl and its manufacturing method | |
CN109758420A (en) | A kind of infant containing various plants antipathogenic composition baths bath foam | |
CN109453087B (en) | Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive | |
CN106377463A (en) | Hydrating toner composition free from preservatives | |
KR101798026B1 (en) | Functional composition having blood circulation and atopy-soothing effect | |
KR101458887B1 (en) | Composition for improving skin condition containing the complex extracts of Pachyrhizus erosus, Brassica oleracea L. var botrytis, Malva sinensis var. mauritiana Mill. and Cetraria islandica | |
CN110638742A (en) | Blackhead guiding composition, convergence relieving composition and blackhead removing composition consisting of blackhead guiding composition and convergence relieving composition | |
CN114224779A (en) | Eye repair composition and application thereof | |
CN110638728B (en) | Skin care composition for removing acne and lightening acne marks and preparation method and application thereof | |
KR20110024315A (en) | Natural antibiotic composition including natural herb extract | |
CN111494258A (en) | Antibacterial, bacteriostatic and halitosis-resisting toothpaste prepared by mixing natural extract and vitamin C and preparation method thereof | |
KR102037927B1 (en) | Cosmetic composition composed of including extracts of drynaria fortunei and cosmetics using the same | |
KR20190074663A (en) | Natural soap composition | |
CN106137875B (en) | A kind of composition and facial mask | |
Mamillapalli et al. | Formulation, phytochemical, physical, biological evaluation of polyherbal vanishing cream, and facewash | |
KR101383519B1 (en) | Composition having excellent antibacterial effect and manufacturing method thereof and cosmetic composition comprising thereof | |
CN110613663A (en) | Skin repairing composition, skin care product and preparation method thereof | |
KR101427462B1 (en) | Composite Natural Antiseptics From Forsythia suspensa Vahl, Leonurus sibiricus L., Crataegi fructus and Akebia quinata Decaisne, Cosmetic Compositions Containing Them | |
KR101876744B1 (en) | A step 3 method for improving skin condition using cosmetic composition comprising a ginseng extract | |
CN104414901A (en) | Nymphaea-tetragona anthocyanidin antioxidative face-pasted mask | |
CN103211734A (en) | Hand cleaner containing multiple natural antibacterial components and preparation technology | |
CN109806205B (en) | Fructus chebulae immaturus extract and antibacterial application thereof | |
CN108888556B (en) | Noni active carrier composition, preparation method and application | |
CN110897950A (en) | Facial mask with anti-inflammatory, moisturizing and whitening effects and preparation method thereof | |
CN112274469B (en) | Traditional Chinese medicine composition and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170208 |
|
RJ01 | Rejection of invention patent application after publication |