CN110897950A - Facial mask with anti-inflammatory, moisturizing and whitening effects and preparation method thereof - Google Patents
Facial mask with anti-inflammatory, moisturizing and whitening effects and preparation method thereof Download PDFInfo
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- CN110897950A CN110897950A CN201911055997.XA CN201911055997A CN110897950A CN 110897950 A CN110897950 A CN 110897950A CN 201911055997 A CN201911055997 A CN 201911055997A CN 110897950 A CN110897950 A CN 110897950A
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- moisturizing
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 230000002087 whitening effect Effects 0.000 title claims abstract description 20
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 18
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 18
- 230000001815 facial effect Effects 0.000 title abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 60
- 239000002994 raw material Substances 0.000 claims abstract description 30
- 238000003756 stirring Methods 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 22
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 22
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 22
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 14
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 14
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 14
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 14
- 229960001631 carbomer Drugs 0.000 claims abstract description 14
- -1 glycerol glucoside Chemical class 0.000 claims abstract description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 13
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 13
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 13
- 229930182478 glucoside Natural products 0.000 claims abstract description 13
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 13
- 239000011734 sodium Substances 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 11
- 125000003118 aryl group Chemical group 0.000 claims abstract description 10
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 10
- 239000002738 chelating agent Substances 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000002562 thickening agent Substances 0.000 claims abstract description 10
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims abstract description 9
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims abstract description 8
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims abstract description 8
- 229950011318 cannabidiol Drugs 0.000 claims abstract description 8
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims abstract description 8
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims abstract description 8
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000005086 pumping Methods 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims description 18
- 241001530056 Athelia rolfsii Species 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical group OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 5
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- 229960003993 chlorphenesin Drugs 0.000 claims description 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 241000628997 Flos Species 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000008104 Prunus humilis Nutrition 0.000 claims description 2
- 241000057271 Prunus humilis Species 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 238000012797 qualification Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 239000002537 cosmetic Substances 0.000 abstract description 8
- 206010061218 Inflammation Diseases 0.000 abstract description 6
- 230000004054 inflammatory process Effects 0.000 abstract description 6
- 238000012360 testing method Methods 0.000 description 25
- 239000012071 phase Substances 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 17
- 244000025254 Cannabis sativa Species 0.000 description 9
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 9
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 9
- 235000009120 camo Nutrition 0.000 description 9
- 235000005607 chanvre indien Nutrition 0.000 description 9
- 239000011487 hemp Substances 0.000 description 9
- 208000002874 Acne Vulgaris Diseases 0.000 description 7
- 206010000496 acne Diseases 0.000 description 7
- 241000218236 Cannabis Species 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 208000026935 allergic disease Diseases 0.000 description 6
- 230000007815 allergy Effects 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000000116 mitigating effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229940094944 saccharide isomerate Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a facial mask with anti-inflammatory, moisturizing and whitening effects, which comprises the following raw materials in percentage by mass: 1 to 3 percent of cannabidiol, 0.3 to 1.0 percent of glycerol glucoside, 0.05 to 0.2 percent of dipotassium glycyrrhizinate, 1 to 5 percent of 1, 3-propylene glycol, 0.5 to 2.0 percent of glycerol, 0.05 to 0.1 percent of sodium hyaluronate, 0.01 to 0.05 percent of sodium polyglutamate, 0.5 to 1.0 percent of saccharide isomer, 0.5 to 1.0 percent of caprylyl hydroximic acid, 0.1 to 0.2 percent of thickening agent, 0.01 to 0.05 percent of chelating agent, 0.01 to 0.1 percent of preservative, 0.1 to 0.3 percent of pH regulator, 0.001 to 0.005 percent of aromatic, 0.01 to 0.05 percent of solubilizer and the balance of water. The preparation method of the facial mask comprises the following steps: and adding the carbomer serving as the raw material in the phase A into a water phase pot containing water and EDTA disodium under the condition of rapid stirring, heating to 85 ℃ under the stirring of 30Hz, stirring until the carbomer is dissolved uniformly, pumping into a main pot, and the like. According to the invention, as the cannabidiol is added into the components and the rich and various functional components are mutually blended, the product has remarkable effects of resisting inflammation, moisturizing and whitening the skin.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a mask with anti-inflammatory, moisturizing and whitening effects.
Background
With the development of society, people pursue beauty more and more. However, due to the influence of computer radiation, outdoor ultraviolet irradiation, dietary factors, living pressure and the like, the face of people is damaged, and the face of some people has symptoms such as allergy, acne, face itching due to wind blowing, dryness and peeling, so that people are worried, especially young people secrete vigorous secretion, and particularly the whelks are the most common. Although a lot of beauty products are used for treating whelk, the effect is not obvious, the skin burden is increased after long-term use, and red swelling, suppuration, pain and the like of the skin are easily caused. Meanwhile, the products often contain hormone substances, although symptoms can be relieved in a short period, pigment spots can be left after long-term use, irreversible influence is generated on the skin, and psychological and physiological damage is caused to patients.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a facial mask with anti-inflammatory, moisturizing and whitening effects, so as to improve the antibacterial and anti-inflammatory effects.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the facial mask with the anti-inflammatory, moisturizing and whitening effects comprises the following raw materials in percentage by mass: 1-3% of wrapped hemp leaf extract, 0.3-1.0% of glycerol glucoside, 0.05-0.2% of dipotassium glycyrrhizinate, 1, 3-propylene glycol 1-5%, 0.5-2.0% of glycerol, 0.05-0.1% of sodium hyaluronate, 0.01-0.05% of sodium polyglutamate, 0.5-1.0% of saccharide isomer, 0.5-1.0% of caprylyl hydroximic acid, 0.1-0.2% of thickening agent, 0.01-0.05% of chelating agent, 0.01-0.1% of preservative, 0.1-0.3% of pH regulator, 0.001-0.005% of aromatic, 0.01-0.05% of solubilizer and the balance of water.
In the facial mask with anti-inflammatory, moisturizing and whitening effects provided by the invention, the facial mask preferably comprises the following raw materials in percentage by mass: 1.5 to 2.5 percent of wrapped hemp leaf extract, 0.5 to 0.8 percent of glycerol glucoside, 0.05 to 0.1 percent of dipotassium glycyrrhizinate, 3 to 5 percent of 1, 3-propylene glycol, 0.5 to 1.5 percent of glycerol, 0.05 to 0.08 percent of sodium hyaluronate, 0.01 to 0.03 percent of sodium polyglutamate, 0.5 to 0.8 percent of saccharide isomer, 0.5 to 0.8 percent of caprylyl hydroximic acid, 0.15 to 0.2 percent of thickening agent, 0.01 to 0.03 percent of chelating agent, 0.05 to 0.1 percent of preservative, 0.1 to 0.2 percent of PH regulator, 0.003 to 0.005 percent of aromatic, 0.01 to 0.03 percent of solubilizer and the balance of water.
In the facial mask with anti-inflammatory, moisturizing and whitening effects provided by the invention, the facial mask preferably comprises the following raw materials in percentage by mass: 2% of wrapped hemp leaf extract, 0.5% of glycerol glucoside, 0.1% of dipotassium glycyrrhizinate, 4% of 1, 3-propylene glycol, 1% of glycerol, 0.06% of sodium hyaluronate, 0.02% of sodium polyglutamate, 0.5% of carbohydrate isomer, 0.6% of caprylyl hydroximic acid, 0.17% of thickening agent, 0.02% of chelating agent, 0.05% of preservative, 0.14% of pH regulator, 0.003% of aromatic, 0.01% of solubilizer and the balance of water.
In the present invention, the water may be deionized water, purified water or distilled water; the thickening agent can be hydrolyzed sclerotium rolfsii gum or carbomer or a mixture of the hydrolyzed sclerotium rolfsii gum and the carbomer; the chelating agent can be disodium EDTA, etc.; the antiseptic can be chlorphenesin, etc.; the pH regulator may be arginine, etc.; the aromatic agent can be Prunus humilis Bunge flower; the solubilizer can be PEG-40 hydrogenated castor oil, etc.
Preferably, the sodium hyaluronate is a complex of sodium hyaluronate of ordinary molecular weight and oligomeric sodium hyaluronate.
On the other hand, the technical problem to be solved by the invention is a preparation method of the facial mask with anti-inflammatory, moisturizing and whitening effects, which divides the raw materials into the following four phases,
phase A comprises water, disodium EDTA, 1, 3-propylene glycol, glycerol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate, carbomer, chlorphenesin and dipotassium glycyrrhizinate;
phase B comprises arginine;
the phase C comprises glycerol glucoside, saccharide isomer, caprylyl hydroxamic acid, and wrapped folium Cannabis extract;
phase D comprises flos Pruni Salicinae and PEG-40 hydrogenated castor oil.
The preparation method comprises the following steps:
step one, adding carbomer serving as a raw material in the phase A into an aqueous phase pot containing water and EDTA disodium under rapid stirring, stirring at 30Hz, heating to 85 ℃, stirring until the carbomer is dissolved uniformly, and pumping into a main pot;
step two, adding the raw materials of 1, 3-propylene glycol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate and sodium hyaluronate pre-dispersed in the phase A into a preparation pot, stirring at 30Hz until the raw materials are completely dissolved, then sequentially adding the rest raw materials in the phase A into the preparation pot, stirring until the raw materials are uniform, and cooling;
step three, cooling to 70 ℃, adding the diluent prepared from the phase B into a preparation pot with the concentration of 10% into the preparation pot, stirring the mixture evenly at 30Hz, and continuously cooling;
step four, cooling to 45 ℃, sequentially adding the C-phase raw materials into a preparation pot, stirring, and continuing stirring at 30Hz for cooling;
and step five, cooling to 40 ℃, adding the phase D after pre-dissolution into a preparation pot, stirring uniformly at 25Hz, taking materials, detecting, filtering with 200-mesh filter cloth after passing, and discharging.
Several components of the present invention are described below:
the cannabis leaf extract is wrapped, the main component of Cannabidiol (CBD) is the main chemical component in the medicinal plant cannabis, the cannabis is a non-addictive component in the cannabis, the anti-inflammatory effect is high, the skin inflammatory symptoms such as acne, eczema and psoriasis can be improved, and the effects of moisture retention, oxidation resistance and the like are achieved.
Dipotassium glycyrrhizinate (Dipotassium Glycyrrhetate) is white powder, sweet in taste, soluble in water, glycerol and propylene glycol, and slightly soluble in absolute ethyl alcohol and diethyl ether. The dipotassium glycyrrhizinate has the effects of resisting inflammation, resisting allergy, preserving moisture and the like. In the pharmaceutical industry, can be used for eye drops and ointment for stomatitis; in the cosmetic industry, the product can be used as skin care product and face cream; in the daily chemical industry, the toothpaste can be used; in the food industry, the potassium replenishing agent can be used as a potassium replenishing agent, a sweet agent, an antistaling agent and a flavoring agent for sports drinks.
The glucoside, APG for short, is synthesized by renewable resources, namely natural fatty alcohol and glucose, is a novel nonionic surfactant with comprehensive performance, has the characteristics of common nonionic and anionic surfactants, has high surface activity, good ecological safety and intermiscibility, and simultaneously has the function of humidifying, and completely meets the performance requirements of active components for cosmetics. APG has been used as an active ingredient to make cosmetics at home and abroad, and such novel cosmetics exhibit good skin moisturizing and skin care properties.
Compared with the prior art, the invention has the following technical effects:
the active component of the facial mask with the anti-inflammatory, moisturizing and whitening effects is the extract of the wrapped hemp leaves, the raw material of the wrapped hemp leaf extract meets the requirement of 'announcement of the national food and drug administration for releasing the name of used cosmetic raw materials (2015 edition) (No. 105 in 2015)', and simultaneously meets the control requirement of the public safety and toxicity control department on industrial hemp products.
In the invention, because the hemp leaf-wrapped extract is added into the components and the rich functional components are mutually blended, the product has the remarkable effects of resisting inflammation, preserving moisture and whitening skin, has the effects of inhibiting bacteria, resisting inflammation and the like, has no stimulation, allergy or toxic or side effect to skin, and is suitable for long-term use.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Examples 1-3 and comparative examples 1-3 each provide a composition having the following formulation, in mass percent, as set forth in table 1 below.
Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
Wrapped hemp leaf extract | 1.0 | 2.0 | 3.0 | 0 | 2.0 | 2.0 |
Glycerol glucoside | 0.3 | 0.2 | 1.0 | 0.2 | 0 | 0.2 |
Glycyrrhizic acid dipotassium salt | 0.05 | 0.1 | 0.2 | 0.1 | 0.1 | 0 |
1, 3-propanediol | 1.0 | 4.0 | 5.0 | 4.0 | 4.0 | 4.0 |
Glycerol | 0.5 | 1.0 | 2.0 | 1.0 | 1.0 | 1.0 |
Hyaluronic acid sodium salt | 0.01 | 0.03 | 0.05 | 0.03 | 0.03 | 0.03 |
Polyglutamic acid sodium salt | 0.01 | 0.02 | 0.05 | 0.02 | 0.02 | 0.02 |
Saccharide isomerate | 0.5 | 0.6 | 1.0 | 0.6 | 0.6 | 0.6 |
Octanoyl hydroximic acid | 0.5 | 0.6 | 1.0 | 0.6 | 0.6 | 0.6 |
Thickening agent | 0.1 | 0.12 | 0.2 | 0.12 | 0.12 | 0.12 |
Chelating agents | 0.01 | 0.05 | 0.1 | 0.05 | 0.05 | 0.05 |
Preservative | 0.01 | 0.05 | 0.1 | 0.05 | 0.05 | 0.05 |
PH regulator | 0.1 | 0.14 | 0.3 | 0.14 | 0.14 | 0.14 |
Aromatic agent | 0.001 | 0.003 | 0.005 | 0.003 | 0.003 | 0.003 |
Solubilizer | 0.01 | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 |
Deionized water | Balance of | Balance of | Balance of | Balance of | Balance of | Balance of |
The compositions of examples 1-3 were prepared by the following procedure:
the raw material is divided into the following four phases,
phase A comprises water, disodium EDTA, 1, 3-propylene glycol, glycerol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate, carbomer, chlorphenesin and dipotassium glycyrrhizinate;
phase B comprises arginine;
the phase C comprises glycerol glucoside, saccharide isomer, caprylyl hydroxamic acid, and wrapped folium Cannabis extract;
phase D comprises flos Pruni Salicinae and PEG-40 hydrogenated castor oil.
The preparation method comprises the following steps:
step one, adding carbomer serving as a raw material in the phase A into an aqueous phase pot containing water and EDTA disodium under rapid stirring, stirring at 30Hz, heating to 85 ℃, stirring until the carbomer is dissolved uniformly, and pumping into a main pot;
step two, adding the raw materials of 1, 3-propylene glycol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate and sodium hyaluronate pre-dispersed in the phase A into a preparation pot, stirring at 30Hz until the raw materials are completely dissolved, then sequentially adding the rest raw materials in the phase A into the preparation pot, stirring until the raw materials are uniform, and cooling;
step three, cooling to 70 ℃, adding the diluent prepared from the phase B into a preparation pot with the concentration of 10% into the preparation pot, stirring the mixture evenly at 30Hz, and continuously cooling;
step four, cooling to 45 ℃, sequentially adding the C-phase raw materials into a preparation pot, stirring, and continuing stirring at 30Hz for cooling;
and step five, cooling to 40 ℃, adding the phase D after pre-dissolution into a preparation pot, stirring uniformly at 25Hz, taking materials, detecting, filtering with 200-mesh filter cloth after passing, and discharging.
Comparative example 1
The difference from the embodiment 2 is that the hemp leaf extract is not contained, and the addition of other components and the preparation process are not changed.
Comparative example 2
The difference from the example 2 is only that glycerol glucoside is not contained, the other components are added, and the preparation process is not changed.
Comparative example 3
The differences from the embodiment 2 are only that dipotassium glycyrrhizinate is not contained, the addition of other component substances and the preparation process are not changed.
Efficacy testing
Test example 1
Testing the healing effect of skin allergy:
60 women between 20 and 40 years old and patients with face allergy are selected, the products prepared in the embodiments 1-3 and the comparative examples 1-3 are tried, 10 persons are randomly selected from the products in each group, the test is carried out for 45 days, and the wiping is carried out after the face is cleaned in the morning and at the evening every day, and the effects are shown in the following table 2:
the criteria for "significant improvement" in table 2 are: the allergy is obviously reduced or disappeared.
The criteria for "mitigation" in table 2 are: reduce allergy to a certain extent, reduce swelling and reduce inflammation.
As can be seen from Table 2, the products of examples 1-3 were significantly improved at a high rate after 45 days of continuous use, significantly higher than the products of comparative examples 1-3, and had no side effects, and no irritation to human skin. The product prepared in example 2 has better treatment effects on symptoms such as skin allergy and pruritus.
Test example 2
Healing efficacy test of skin acne:
selecting 60 facial acne patients between 20-40 years old, trying the products prepared in the embodiments 1-3 and the comparative examples 1-3, randomly selecting 10 people from each group of products, testing for 45 days, cleaning the face every morning and evening, and then wiping, wherein the effects are shown in table 2:
obviously improve | Mitigation | No effect | Side effects | |
Example 1 | 7 | 3 | 0 | 0 |
Example 2 | 9 | 1 | 0 | 0 |
Example 3 | 8 | 2 | 0 | 0 |
Comparative example 1 | 0 | 0 | 10 | 0 |
Comparative example 2 | 0 | 1 | 9 | 0 |
Comparative example 3 | 0 | 1 | 9 | 0 |
The criteria for "significant improvement" in table 2 are: acne is significantly reduced or eliminated.
The criteria for "mitigation" in table 2 are: the acne is relieved to a certain extent, and swelling and inflammation are reduced.
As can be seen from Table 2, the products of examples 1-3 were significantly improved at a high rate after 45 days of continuous use, significantly higher than the products of comparative examples 1-3, and had no side effects, and no irritation to human skin. Among them, the product prepared in example 2 has better treatment of acne symptoms.
Test example 3
Whitening efficacy test (T/ZHCA 001-2018)
Reagents and materials: laboratory water, which adopts tertiary water in GB/T6682; masks in examples 1 to 3 and comparative examples 1 to 3; a non-dusting absorbent dry tissue.
Testing instrument
A tristimulus value colorimeter; analytical balance, precision 0.0001 g.
And (3) testing conditions are as follows:
testing the environmental temperature of 20-22 ℃ and the relative humidity of 40-60%, and carrying out real-time dynamic monitoring;
the testing conditions of testers, places, instruments and the like in the testing process are kept consistent.
Test method
The number of the testees is 30, the test part is the forearm area side, and before each test, the testees clean the tested part uniformly and suck the tested part by using a non-scrap water-absorbing dry paper towel.
The product is required to be evenly smeared; the left and right arms were randomized to test areas and the subjects were applied once a day, morning and evening, for a 5 week period. During the test period, the test area was not filled with any other cosmetic.
The test results are shown in Table 2.
As can be seen from table 2, the skin ITA ° values of the samples tested at the test sites tended to increase compared to the initial values over the time period from week 0 to week 5 of the experimental period. Among them, the difference of the ITA ° values of the test groups of examples 1 to 3 is significantly different, and the difference of the ITA ° values of the test groups of comparative examples 1 to 3 is not significant, so that the whitening effect of the test groups of examples 1 to 3 is significantly higher than that of the test groups of comparative examples 1 to 3. Wherein example 2 is more superior to examples 1 and 2 in effect.
The embodiments of the present invention have been described in detail, but the embodiments are only examples, and the present invention is not limited to the above-described embodiments. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Therefore, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.
Claims (6)
1. The mask with the anti-inflammatory, moisturizing and whitening effects is characterized by comprising the following raw materials in percentage by mass: 1 to 3 percent of cannabidiol, 0.3 to 1.0 percent of glycerol glucoside, 0.05 to 0.2 percent of dipotassium glycyrrhizinate, 1 to 5 percent of 1, 3-propylene glycol, 0.5 to 2.0 percent of glycerol, 0.05 to 0.1 percent of sodium hyaluronate, 0.01 to 0.05 percent of sodium polyglutamate, 0.5 to 1.0 percent of saccharide isomer, 0.5 to 1.0 percent of caprylyl hydroximic acid, 0.1 to 0.2 percent of thickening agent, 0.01 to 0.05 percent of chelating agent, 0.01 to 0.1 percent of preservative, 0.1 to 0.3 percent of pH regulator, 0.001 to 0.005 percent of aromatic, 0.01 to 0.05 percent of solubilizer and the balance of water.
2. The anti-inflammatory, moisturizing and whitening mask as claimed in claim 1, which is characterized by comprising the following raw materials in percentage by mass: 1.5 to 2.5 percent of cannabidiol, 0.5 to 0.8 percent of glycerol glucoside, 0.05 to 0.1 percent of dipotassium glycyrrhizinate, 3 to 5 percent of 1, 3-propylene glycol, 0.5 to 1.5 percent of glycerol, 0.05 to 0.08 percent of sodium hyaluronate, 0.01 to 0.03 percent of sodium polyglutamate, 0.5 to 0.8 percent of saccharide isomer, 0.5 to 0.8 percent of caprylyl hydroximic acid, 0.15 to 0.2 percent of thickening agent, 0.01 to 0.03 percent of chelating agent, 0.05 to 0.1 percent of preservative, 0.1 to 0.2 percent of PH regulator, 0.003 to 0.005 percent of aromatic, 0.01 to 0.03 percent of solubilizer and the balance of water.
3. The anti-inflammatory, moisturizing and whitening mask as claimed in claim 2, which is characterized by comprising the following raw materials in percentage by mass: cannabidiol 2%, glycerol glucoside 0.5%, dipotassium glycyrrhizinate 0.1%, 1, 3-propylene glycol 4%, glycerol 1%, sodium hyaluronate 0.06%, sodium polyglutamate 0.02%, saccharide isomer 0.5%, caprylyl hydroximic acid 0.6%, thickening agent 0.17%, chelating agent 0.02%, preservative 0.05%, pH regulator 0.14%, aromatic 0.003%, solubilizing agent 0.01%, and the balance of water.
4. An anti-inflammatory moisturizing and whitening mask as in any of claims 1 to 3, characterized in that the sodium hyaluronate is a complex of sodium hyaluronate of ordinary molecular weight and oligomeric sodium hyaluronate.
5. An anti-inflammatory moisturizing and whitening mask as claimed in any of claims 1 to 3, characterized in that the water is deionized water, purified water or distilled water;
the thickening agent is selected from hydrolyzed sclerotium rolfsii gum or/and carbomer;
the chelating agent is selected from disodium EDTA;
the preservative is selected from chlorphenesin;
the pH regulator is selected from arginine;
the aromatic is selected from Prunus humilis Bunge flower;
the solubilizer is selected from PEG-40 hydrogenated castor oil.
6. A method for preparing a mask having anti-inflammatory, moisturizing and whitening effects according to any one of claims 1 to 3,
firstly, the raw material is divided into the following four phases,
phase A comprises water, disodium EDTA, 1, 3-propylene glycol, glycerol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate, carbomer, chlorphenesin and dipotassium glycyrrhizinate;
phase B comprises arginine;
the phase C comprises glycerol glucoside, saccharide isomer, octanoyl hydroximic acid, and cannabidiol;
phase D comprises flos Pruni Salicinae and PEG-40 hydrogenated castor oil.
The preparation method comprises the following steps:
step one, adding carbomer serving as a raw material in the phase A into a water phase pot containing water and EDTA disodium under the condition of rapid stirring, heating to 85 ℃ under the stirring of 30Hz, stirring until the carbomer is dissolved uniformly, and pumping into a main pot;
step two, adding the raw materials of 1, 3-propylene glycol, hydrolyzed sclerotium rolfsii gum, sodium hyaluronate, sodium polyglutamate and sodium hyaluronate pre-dispersed in the phase A into a preparation pot, stirring at 30Hz until the raw materials are completely dissolved, then sequentially adding the rest raw materials in the phase A into the preparation pot, stirring uniformly, and cooling;
step three, cooling to 70 ℃, adding the diluent prepared from the phase B into a preparation pot with the concentration of 10% into the preparation pot, stirring the mixture evenly at 30Hz, and continuously cooling;
step four, cooling to 45 ℃, sequentially adding the C-phase raw materials into a preparation pot, stirring, and continuing stirring at 30Hz for cooling;
and step five, cooling to 40 ℃, adding the phase D after pre-dissolution into a preparation pot, stirring uniformly at 25Hz, taking materials, detecting, filtering with 200-mesh filter cloth after qualification, and discharging.
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