KR20150116504A - A cosmetics composition containing tea tree and solt - Google Patents
A cosmetics composition containing tea tree and solt Download PDFInfo
- Publication number
- KR20150116504A KR20150116504A KR1020140041090A KR20140041090A KR20150116504A KR 20150116504 A KR20150116504 A KR 20150116504A KR 1020140041090 A KR1020140041090 A KR 1020140041090A KR 20140041090 A KR20140041090 A KR 20140041090A KR 20150116504 A KR20150116504 A KR 20150116504A
- Authority
- KR
- South Korea
- Prior art keywords
- tea tree
- salt
- skin
- extract
- present
- Prior art date
Links
- 235000009024 Ceanothus sanguineus Nutrition 0.000 title claims abstract description 83
- 240000003553 Leptospermum scoparium Species 0.000 title claims abstract description 83
- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 83
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 239000002537 cosmetic Substances 0.000 title claims abstract description 44
- 101100166829 Mus musculus Cenpk gene Proteins 0.000 title 1
- 239000000284 extract Substances 0.000 claims abstract description 80
- 150000003839 salts Chemical class 0.000 claims abstract description 58
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 18
- 229920002674 hyaluronan Polymers 0.000 claims description 18
- 229960003160 hyaluronic acid Drugs 0.000 claims description 18
- 239000006210 lotion Substances 0.000 claims description 17
- 239000006071 cream Substances 0.000 claims description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 8
- 235000016709 nutrition Nutrition 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 235000019439 ethyl acetate Nutrition 0.000 claims description 4
- 230000003020 moisturizing effect Effects 0.000 abstract description 21
- 239000000126 substance Substances 0.000 abstract description 11
- 230000001965 increasing effect Effects 0.000 abstract description 8
- 230000005764 inhibitory process Effects 0.000 abstract description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 4
- 239000011707 mineral Substances 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 3
- 230000007812 deficiency Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 51
- 235000002639 sodium chloride Nutrition 0.000 description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 16
- 101710128038 Hyaluronan synthase Proteins 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 230000000845 anti-microbial effect Effects 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 210000004927 skin cell Anatomy 0.000 description 8
- 230000004044 response Effects 0.000 description 7
- 108010003272 Hyaluronate lyase Proteins 0.000 description 6
- 102000001974 Hyaluronidases Human genes 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000000686 essence Substances 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 229960002773 hyaluronidase Drugs 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 230000009759 skin aging Effects 0.000 description 5
- 235000013599 spices Nutrition 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000004792 oxidative damage Effects 0.000 description 3
- -1 pack Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 229940111630 tea tree oil Drugs 0.000 description 3
- 239000010677 tea tree oil Substances 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 241000217937 Halimodendron halodendron Species 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 241001514662 Leptospermum Species 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- 241000378467 Melaleuca Species 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006533 astragalus Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000012907 medicinal substance Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000018343 nutrient deficiency Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRYLYDPHFGVWKC-JTQLQIEISA-N (R)-(-)-p-Menth-1-en-4-ol Natural products CC(C)[C@@]1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-JTQLQIEISA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
- WRYLYDPHFGVWKC-UHFFFAOYSA-N 4-terpineol Chemical compound CC(C)C1(O)CCC(C)=CC1 WRYLYDPHFGVWKC-UHFFFAOYSA-N 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 241001105098 Angelica keiskei Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- SMDOOINVMJSDPS-UHFFFAOYSA-N Astragaloside Natural products C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)=C1 SMDOOINVMJSDPS-UHFFFAOYSA-N 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007269 Carcinogenicity Diseases 0.000 description 1
- 208000009043 Chemical Burns Diseases 0.000 description 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 241000371652 Curvularia clavata Species 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241001514666 Kunzea Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000010195 Onychomycosis Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- QMNWISYXSJWHRY-XWJCTJPOSA-N astragaloside Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)C4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)CC3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-XWJCTJPOSA-N 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000007670 carcinogenicity Effects 0.000 description 1
- 231100000260 carcinogenicity Toxicity 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000007665 chronic toxicity Effects 0.000 description 1
- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- FVIZARNDLVOMSU-UHFFFAOYSA-N ginsenoside K Natural products C1CC(C2(CCC3C(C)(C)C(O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O FVIZARNDLVOMSU-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000002044 hexane fraction Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 231100000944 irritant response Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N lauric acid triglyceride Natural products CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 201000005882 tinea unguium Diseases 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 235000018648 unbalanced nutrition Nutrition 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 티트리 추출물 및 소금을 함유한 조성물을 통해 HA의 함량 증가에 따른 보습효과의 기전으로 HaCaT에서 HA 생산과 HYAL 저해를 통해 피부의 당김, 거칠음, 탄력 부족현상을 개선하는 티트리 추출물 및 소금을 포함하는 화장료 조성물에 관한 것으로서, 그 특징은 천연소금을 800℃ 이상의 고온으로 7 ~ 8 시간 동안 가열하여 소금의 모든 유해물질이 제거되고, 가열된 천연소금은 무기질 성분 및 미네랄 성분은 피부의 보습효과 및 피부의 재생에도 뛰어난 효과와, 이를 본 발명의 티트리 추출물과 함께 사용하면 그 효능을 향상시킬 수 있는 티트리 추출물 및 소금을 함유한 조성물을 제공하는데 있다.The present invention relates to a tea tree extract which improves skin pulling, roughness and elasticity deficiency through HA production and HYAL inhibition in HaCaT as a mechanism of moisturizing effect by increasing HA content through tea tree extract and a composition containing salt, The present invention relates to a cosmetic composition comprising a salt, wherein the natural salt is heated at a high temperature of 800 ° C or higher for 7 to 8 hours to remove all the harmful substances of the salt, and the heated natural salt has an inorganic component and a mineral component, And a composition containing tea tree extract and salt, which can improve the efficacy of the tea tree extract of the present invention when used together with the tea tree extract of the present invention.
Description
본 발명은 티트리 추출물 및 소금을 포함하는 화장료 조성물에 관한 것으로 보다 상세하게는, 티트리 추출물 및 소금을 함유한 조성을 통해 HA의 함량 증가에 따른 보습효과의 기전으로 HaCaT에서 HA 생산과 HYAL 저해를 통해 피부의 당김, 거칠음, 탄력 부족현상을 개선하는 티트리 추출물 및 소금을 포함하는 화장료 조성물에 관한 것이다.
The present invention relates to a cosmetic composition comprising tea tree extract and salt. More particularly, the present invention relates to a cosmetic composition comprising tea tree extract and salt, To a cosmetic composition comprising tea tree extract and salt which improves skin pulling, roughness, lack of elasticity, and the like.
피부는 외부에서부터 순서대로 표피, 진피, 피하 조직의 3개 층으로 크게 구분되며, 체내의 제 기관을 기온 및 습도 변화, 자외선, 기타 물리적, 화학적인 외부 환경의 자극으로부터 보호해 주는 기능이 있다. The skin is largely divided into three layers: epidermis, dermis, and subcutaneous tissue in order from the outside. It has a function to protect the internal organs of the body from changes in temperature and humidity, ultraviolet rays, and other physical and chemical external stimuli.
피부의 노화는 자유라디칼(free-radical)에 의한 세포내 물질의 산화적 손상이 원인이 된다. 즉, 하이드록시 라디칼, 슈퍼옥사이드 라디칼 등의 활성 산소와 같은 높은 반응성의 자유라디칼은 세포막을 구성하는 지방 성분을 산화시켜 세포막을 파괴하고, 이 결과로 단백질을 산화시키며 핵산의 기능을 정지시켜 결국 생체내 성분을 파괴하고 세포사멸을 일으킨다. 이와 같은 피부노화의 원인으로는 과다한 자외선 노출, 피부세포의 영양 결핍 및 화장품의 부작용 등을 들 수 있다.Skin aging is caused by oxidative damage of intracellular substances by free radicals. That is, highly reactive free radicals, such as active radicals such as hydroxy radicals and superoxide radicals, oxidize the lipid components constituting the cell membrane to destroy the cell membrane, thereby oxidizing the protein and stopping the function of the nucleic acid, It destroys its components and causes cell death. Such skin aging can be caused by excessive exposure to ultraviolet rays, nutritional deficiency of skin cells, and side effects of cosmetics.
피부세포 영양결핍의 주된 원인으로는 무리한 다이어트, 불규칙한 식사등 불균형적인 영양으로 인한 피부세포의 영양결핍이 있으며, 이러한 결과로 진피층에 존재하는 콜라겐(collagen)의 생성이 억제되어 피부의 수분이 증발하는 증상이 나타나며, 또한 피하지방층에 이상이 생겨 피부의 탄력이 손실되는 원인이 된다.The major cause of skin cell nutritional deficiency is the inadequate nutrition of skin cells due to unbalanced nutrition such as excessive diet and irregular diet. As a result, the production of collagen in the dermal layer is inhibited and the moisture of the skin is evaporated Symptoms appear, and it also causes abnormalities in the subcutaneous fat layer, causing loss of skin elasticity.
특히, 표피에서는 인체 내부의 수분증발을 방지하는 중요한 역할을 한다. 표피는 외부로부터 순서대로 각질층, 과립층, 유극층, 기저층으로 구분되며, 각질층의 세포들은 벽돌과 같은 역할을 하고, 각질세포 사이의 세포간 지질들은 모르타르와 같은 역할로 작용하여 피부 장벽을 구성한다. 또한, 건강한 사람의 각질세포에는 고농도의 자연보습인자(Natural Moisturing Factor, NMF)가 존재하여 피부의 수분 보유를 돕는데, 예를 들면 아미노산과 같은 물질은 수용성이기 때문에 효과적으로 수분과 결합하여 피부에서 수분이 건조되는 것을 억제한다.In particular, the epidermis plays an important role in preventing water evaporation inside the human body. The epidermis is divided into stratum corneum, granular layer, superficial layer, and basal layer in order from the outside. Cells of stratum corneum act like bricks, and intercellular lipids between keratinocytes act like mortar to constitute skin barrier. In addition, a healthy human keratinocyte has a high concentration of natural moisturizing factor (NMF) to help maintain moisture in the skin. For example, substances such as amino acids are water-soluble, Thereby suppressing drying.
또한, 과도한 환경오염으로 인해 오존층이 파괴되면서 자외선에 존재하는 입자가 음(-)이온을 형성하여 피부세포를 구성하는 단백질 분자와 결합하면서 자유라디칼을 생성하게 되는데, 이는 불안정한 물질로 피부세포의 단백질과 반응하여 피부세포의 단백질을 다른 단백질로 변화시켜 결국 피부세포를 크게 손상시키고, 이렇게 손상된 피부세포는 자기 고유의 세포 기능이 불가능해져 피부세포가 노화되게 된다.In addition, as the ozone layer is destroyed due to excessive environmental pollution, the particles in the ultraviolet rays form negative ions and combine with the protein molecules constituting the skin cells to generate free radicals. This is an unstable substance, And the protein of the skin cell is converted into another protein, thereby greatly damaging the skin cell. The damaged skin cell becomes unable to function as its own cell, and the skin cell becomes aged.
이외에도 화장품의 부작용으로 피부의 지방과 수분의 조화를 파괴하는 것도 피부노화의 원인이 된다. 따라서 생체내의 산화적 손상을 억제함으로써 피부의 노화를 예방하거나 줄일 수 있다. 한편 항산화 화장료는 지방 성분의 산화를 포함한 피부의 산화적 손상을 억제하여 피부의 노화를 예방, 또는 지연시키는 작용을 한다.In addition, the side effects of cosmetics to break the harmony of fat and moisture in the skin causes skin aging. Therefore, it is possible to prevent or reduce skin aging by inhibiting oxidative damage in vivo. Antioxidant cosmetics, on the other hand, inhibit the oxidative damage of skin, including the oxidation of fat components, to prevent or delay skin aging.
그러나, 요즘과 같이 환경의 변화나 생활 패턴의 변화에 따른 냉/난방의 인위적인 온도 조절, 사회 생활에서 발생되는 각종 스트레스와 환경 오염으로 인한 피부 스트레스, 화장 습관에 따른 잦은 세안 및 연령 증가에 따른 자연적인 피부 노화 등의 여러 가지 원인으로 인하여 각질층의 수분이 감소하여 피부가 건조해지고 표면이 거칠게 되며 피부가 푸석거리고 윤기를 잃어 칙칙하게 보이는 등의 현상이 발생하기 때문에 피부 보습제의 필요가 증가하고 있다.However, as it is nowadays, there is a tendency to adjust the temperature of the air / heating due to the change of environment or life pattern, the stress caused by various stresses and environmental pollution in the social life, frequent washing according to make- Due to various causes such as aging of skin and the like, moisture of the stratum corneum is reduced, and the skin becomes dry, the surface becomes rough, the skin becomes loose, the luster is lost and the skin looks dull, and the need for skin moisturizing agent is increasing.
지금까지 항산화 작용을 갖는 것으로 알려진 물질은 퀘세틴(Quercetin) ,알파-토코페롤(α-tocopherol), 아스코르빈산(ascorbic acid), 베타카로틴(β-carotene), 하이드로퀴논 (hydroquinone) 등이 알려져 있다. 그러나 이러한 물질들은 대부분 화학적으로 합성한 물질로, 이들 화학 물질은 안전성에 대한 우려가 있어 사용이 제한되거나 일부 국한되어 있으며, 이러한 유독성분이 지속적으로 체내에 축적될 경우 만성 독성, 발암성, 돌연 변이 유발등 그에 따른 부작용이 발생될 수 있다. Quercetin, alpha-tocopherol, ascorbic acid, beta-carotene, hydroquinone and the like have been known to have antioxidative action so far . However, most of these substances are chemically synthesized. These chemicals are limited or limited in use due to safety concerns. If these toxic substances are continuously accumulated in the body, they may cause chronic toxicity, carcinogenicity, mutagenicity And so forth.
피부에서 일정 수분을 유지한다는 것은 물분자들이 증발한다는 점을 고려하면 수분을 잃지 않기 위한 장벽을 구성한다는 의미가 포함된다고 생각한다. Maintaining a constant water content in the skin implies that it constitutes a barrier to avoid water loss, considering that water molecules evaporate.
이러한 장벽이 원활히 작동하기 위해 여러 종류의 지질, 당, 단백질 등이 관여하고 상호작용한다. Hyaluronic acid(HA)의 구조식에 따라 이중 Hyaluronic acid (이하 HA)는 세포외 연결 조직에 존재하는 고분자의 glycosaminoglycan으로서 수분 증발을 막는 장벽의 역할을 수행한다고 알려져 있고, 나이가 들어감에 따라 HA의 함량이 줄어든다고 보고되었다.Several kinds of lipids, sugars, and proteins are involved and interact in order for these barriers to work smoothly. According to the structural formula of hyaluronic acid (HA), double hyaluronic acid (HA) is known to be a glycosaminoglycan of a polymer present in extracellular connective tissues and acts as a barrier against moisture evaporation. It was reported to be reduced.
외부의 환경적 요인 중 특히 자외선의 장기 노출은 피부의 일정한 HA 유지에 부정적 영향을 준다. 이러한 내재적 혹은 외재적 요인으로 인한 HA의 함량 감소는 피부의 탄력 감소, 거친 피부, 주름의 한 요인이 된다. 따라서 피부에서 HA의 함량유지는 피부 보습은 물론 미용상 젊은 피부를 유지하는데 있어 매우 중요하다. Long-term exposure to UV radiation, especially from external environmental factors, has a negative impact on the maintenance of a constant HA of the skin. The decrease in HA content due to these intrinsic or extrinsic factors is a factor of skin elasticity reduction, rough skin and wrinkles. Therefore, maintaining the HA content in the skin is very important for keeping skin moisturized as well as young skin for cosmetics.
HA는 지속적인 Hyaluronic acid Synthase(HAS)에 의한 합성과 Hyaluronidase (HYAL)에 의한 분해에 의해 함량이 조절된다. 피부에서 HA의 함량을 유지 혹은 증대시키는 방법 중에 하나는 HA의 합성을 증가시킴과 동시에 HA의 분해를 억제한다.The content of HA is controlled by the synthesis by continuous hyaluronic acid synthase (HAS) and the degradation by hyaluronidase (HYAL). One method of maintaining or increasing HA content in the skin is to increase the synthesis of HA while at the same time inhibiting HA degradation.
따라서, Hyaluronic acid Synthase(HAS)의 유전자 발현의 증가와 Hyaluronidase(HYAL) 활성 감소를 시키는 능력이 있는 약재 혹은 이 두 가지 기능이 있는 약재의 혼합은 피부의 보습력을 강화시키는 방법이 될 수 있는 것을 확인하였다. 실제로 많은 천연물과 물질들이 HAS의 유전자 발현 증가를 통해 HA의 생산량을 증가시킨다고 보고되고 있으며 대표적으로 Black rice, 인삼에서 분리한 compound K,kaempferol, quercetin, retinoic acid 등이 있다. Therefore, it has been confirmed that the combination of a medicinal substance capable of increasing hyaluronic acid synthase (HAS) gene expression and a decrease in hyaluronidase (HYAL) activity or a medicinal substance having these two functions can be a method for enhancing the moisturizing power of the skin Respectively. Indeed, many natural products and substances have been reported to increase the production of HA through increased gene expression of HAS, including black rice, compound K, kaempferol, quercetin and retinoic acid isolated from ginseng.
이에, 본 발명자들은 티트리 잎의 추출물과 소금의 유효성분을 함유한 화장료 조성을 통해 피부와 관련하여 피부수분함량 측정 시험에서 보습효과를 확인하여 humankeratinocyte인 HaCaT에서 HA 생산과 HYAL 저해에 미치는 영향을 확인하고, 본 발명을 완성하였다.
Therefore, the present inventors confirmed the moisturizing effect in the skin moisture content measurement test through the composition of the cosmetic composition containing the tea tree leaf extract and the active ingredient of the salt, and confirmed the effect of the humankeratinocyte HaCaT on HA production and HYAL inhibition And completed the present invention.
[관련기술문헌][Related Technical Literature]
1. 피부보습용 화장료 조성물(Cosmetic composition for skin miosture) (특허출원번호 제10-2004-0083125호)1. Cosmetic composition for skin miosture (Patent Application No. 10-2004-0083125)
2. 옹기를 구비하는 추출기로부터 추출된 황기 추출물을 유효성분으로 함유하는 피부 외용제 조성물(Composition for skin external application comprising Astragalus Membranaceus extract prepared by using pottery extractor) (특허출원번호 제10-2007-0123388호)2. Composition for skin external application comprising Astragalus Membranaceus extract prepared by using pottery extract (Patent Application No. 10-2007-0123388) containing an extract of Angelica keiskei koidz
3. 아스트라갈로사이드를 다량 함유한 황기 추출물을 포함하는 화장료 조성물(Cosmetic composition containing the extract of Astragali Radix with lots of astragloside) (특허출원번호 10-2009-0116784호)
3. Cosmetic composition containing extract of Astragalus containing a large amount of astragaloside (Patent Application No. 10-2009-0116784)
본 발명은 상기와 같은 문제점을 해결하기 위해 안출된 것으로서, 그 목적은 티트리 추출물 및 소금을 함유한 조성을 통해 HA의 함량 증가에 따른 보습효과의 기전으로 HaCaT에서 HA 생산과 HYAL 저해를 통해 피부의 당김, 거칠음, 탄력 부족현상을 개선하는 티트리 추출물 및 소금을 포함하는 화장료 조성물을 제공하고자 한다.
The object of the present invention is to solve the above-mentioned problems, and it is an object of the present invention to provide a composition containing tea tree extract and salt, which is a mechanism of moisturizing effect by increasing HA content, And to provide a cosmetic composition comprising tea tree extract and salt which improves pulling, roughness and lack of elasticity.
상기의 목적을 달성하기 위한 본 발명의 특징에 따르면, 티트리(Tea Tree) 잎부 추출물과 소금의 유효성분으로 Hyaluronic aid synthase(HaCaT) 세포에서 Hyaluronic acid(HA) 생성으로 피부 보습을 유지하는 것을 특징으로 하는 티트리 잎부 추출물과 소금을 포함하는 화장료 조성물을 제공하는데 있다.According to an aspect of the present invention to achieve the above object, the present invention provides a method for producing a hyaluronic acid synthase (HaCaT) cell, which is an active ingredient of tea tree leaf extract and salt, And a cosmetic composition comprising the tea tree leaf extract and the salt.
또한, 본 발명의 실시예에 따른 티트리 잎부 추출물과 소금을 포함하는 화장료 조성물은 상기 티트리 잎부는 n-Hexane, CHCl3 또는 EtOAc 용매를 이용하여 추출한 추출물과 이를 용매를 이용하여 순차적으로 추출한 분획물을 포함하는 것을 특징으로 한다.In addition, the cosmetic composition comprising tea tree leaf extract and salt according to an embodiment of the present invention is characterized in that the tea tree leaf part is an extract obtained by using n-hexane, CHCl 3 or EtOAc solvent and a fraction obtained by sequentially extracting it with a solvent And a control unit.
또한, 본 발명의 실시예에 따른 티트리 잎부 추출물과 소금을 포함하는 화장료 조성물은 상기 티트리 잎 추출물이 유효성분으로 조성물 전체 중량에 대하여 0.1 내지 10 중량%을 함유하고, 구운 소금을 8 중량% 함유하여 유연화장수(스킨), 수렴화장수, 영양화장수(로션), 영양크림, 맛사지크림, 세안제 또는 에센스의 혼합물인 것을 특징으로 한다.
In addition, the cosmetic composition comprising tea tree leaf extract and salt according to an embodiment of the present invention is characterized in that the tea tree leaf extract contains 0.1 to 10% by weight based on the total weight of the composition as an active ingredient, 8% (Skin), a convergent lotion, a nutritional lotion (lotion), a nutritional cream, a massage cream, a cleanser or an essence.
본 발명에 따른 티트리 추출물 및 소금을 포함하는 화장료 조성물은 티트리 추출물 및 소금을 함유한 조성을 통해 HA의 함량 증가에 따른 보습효과의 기전으로 HaCaT에서 HA 생산과 HYAL 저해를 통해 피부의 당김, 거칠음, 탄력 부족현상을 개선할 수 있다.The tea tree extract and the cosmetic composition containing the salt according to the present invention are characterized by a composition containing tea tree extract and salt as a mechanism of moisturizing effect by increasing the content of HA, and by HA production and HYAL inhibition in HaCaT, , The elasticity shortage phenomenon can be improved.
또한, 본 발명의 티트리 추출물 및 소금을 포함하는 화장료 조성물은 천연소금을 800℃ 이상의 고온으로 7 ~ 8 시간 동안 가열하여 소금의 모든 유해물질이 제거되고, 가열된 천연소금은 무기질 성분 및 미네랄 성분은 피부의 보습효과 및 피부의 재생에도 뛰어난 효과와, 이를 본 발명의 티트리 추출물과 함께 사용하면 그 효능을 향상시키는 효과를 얻을 수 있다.
In addition, the cosmetic composition comprising the tea tree extract and the salt of the present invention is prepared by heating the natural salt at a high temperature of 800 ° C or higher for 7 to 8 hours to remove all harmful substances of the salt, and the heated natural salt contains the mineral component and the mineral component Can exert an effect of moisturizing the skin and regenerating the skin, and when used together with the tea tree extract of the present invention, the effect of improving the efficacy can be obtained.
도 1은 본 발명의 티트리 잎부의 각 분획물을 제조하는 과정을 나타낸 도면
도 2는 본 발명의 티트리 추출물 및 소금이 함유된 크림의 사용에 따른 수분손실률의 측정결과를 도시한 그래프
도 3은 본 발명의 실시예에 따른 티트리 추출물 및 소금을 포함하는 화장료 조성물이 인체에 사용시 피부의 수분보유율의 시간 경과에 따라 측정결과를 도시한 그래프BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a view showing a process for producing each fraction of a tea tree leaf part of the present invention
2 is a graph showing the results of measurement of the water loss rate according to the use of the tea tree extract of the present invention and the cream containing the salt
FIG. 3 is a graph showing the results of measurement of the water retention rate of the skin when the cosmetic composition containing the tea tree extract and the salt according to the embodiment of the present invention is applied to human body
이하, 본 발명의 바람직한 실시예에 따른 티트리 추출물 및 소금을 함유한 화장료 조성물에 대하여 상세하게 설명하기로 한다.Hereinafter, the tea tree extract and the cosmetic composition containing the salt according to a preferred embodiment of the present invention will be described in detail.
상세한 설명은 첨부된 도면들을 참조하여 설명할 것이다. 하기에서 본 발명을 설명함에 있어서, 관련된 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 것이다.
The detailed description will be made with reference to the accompanying drawings. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.
상기와 같이 구성된 본 발명의 화장료 조성물의 원료인 티트리, 소금에 대한 특징 및 효능에 대하여 간략히 설명하면 다음과 같다.The characteristics and efficacy of the tea tree and salt, which are the raw materials of the cosmetic composition of the present invention, will be briefly described below.
티트리는 Leptospermum, Melaleuca, Kunzea 속에 해당하며, 세계적으로 Leptospermum 속(genus)에 약 86 종, Melaleuca 속에 약 230여종의 식물이 알려져 있다. Tea tree belongs to Leptospermum, Melaleuca, Kunzea. About 86 species are known to Leptospermum genus and about 230 species are found in Melaleuca.
원산지는 오스트레일리아로 뉴사우스웨일스주에서 자생한다. 높이 약 6m까지 늪지대에서 자라며 생명력이 강해서 줄기를 잘라내도 잘 자란다. 공기를 상쾌하게 정화하는 역할을 하는 허브의 한 종류이다. Origin is native to Australia and New South Wales. It grows in a marshy area up to about 6m in height. It grows well even if it cuts its stem because its vitality is strong. It is a kind of hub that plays a role of refreshing air.
오스트레일리아 원주민들은 이미 오래전부터 티트리 나무의 잎으로 베인 상처에 생긴 감염증을 치료해왔다. 제2차 세계대전 중에는 피부 창상의 치료제로서 열대지방의 군인에게 지급되었다. 외과와 치과에서 사용되며 살균소독제·탈취제·비누·공기정화제에도 넣어 사용하며, 이 밖에도 각종 감염증, 감기, 입냄새, 무좀, 비듬 등에도 효과가 있다. 그러나 자극성이 강하기 때문에 원액을 희석시켜 사용하는 것이 좋다.Aboriginal Australians have long been treating infections caused by cuts of leaf tea tree leaves. During the Second World War, it was paid to soldiers in the tropics as a treatment for skin wounds. It is used in surgery and dentistry. It is also used in disinfectant disinfectant, deodorant, soap, air purifier. It is also effective in various infectious diseases, cold, bad breath, athlete's foot, dandruff. However, since it is highly irritant, it is recommended to dilute the stock solution.
티트리는 자극성이 강하기 때문에 원액을 아몬드, 아프리코트, 헤즐넛과 같은 캐리어 오일에 2%를 희석하여 사용하며, 항 박테리아, 항바이러스 항진균 효과와 더불어 가장 강력한 면역 자극제, 백혈구를 활성화시켜 체내에 침입한 유기체에 대한 방어선을 구축하고 병에 걸려있는 기간을 단축하고, 호흡계 및 비뇨기계에 항박테리아 작용으로 호흡기계 및 비뇨기계 감염에 사용되는 물질이다.Because Tea Tree is highly irritant, it dilutes 2% of carrier liquid such as almond, apricot, and hazelnut, and is the most powerful immunostimulant with antibacterial and antiviral antifungal effect. It activates leukocyte, It is a substance that is used for respiratory and urinary tract infections by constructing a defense line, shortening the period of illness and antibacterial action on the respiratory system and urinary tract.
티트리 오일이 햇빛에 노출되면, 미량의 성분인 파라시멘이 3%에서 305d로 급격히 늘어나며, 항 미생물효과가 있는 terpinene-4-ol이 산화되어 트리하이드톡시멘테인으로 변화된다. Para-cymene은 피부에 고통스러운 홍반과 부종을 유발하는 원소로 밝혀졌으며 산화된 티트리 오일을 피부에 사용할 경우 증상의 치료를 지연시킬 뿐만 아니라 화학적 화상을 일으켜 이러한 급격한 산화를 막기 위해 항상 차광병에 보관해야 한다.When tea tree oil is exposed to sunlight, the trace amount of paracimen is rapidly increased from 3% to 305d, and terpinene-4-ol, which has an antimicrobial effect, is oxidized and converted to trihydroxydentimene. Para-cymene has been shown to cause painful erythema and edema on the skin, and oxidized tea tree oil, when applied to the skin, not only delays the treatment of the symptoms but also causes chemical burns, Must be kept.
또한, tea tree oil의 Escherichia coli (J.E. Gustafson et al, 1998, S.D. Cox et al 1998, M.R. Moreira et al, 2005)), Staphylococcus aureus (C.H. Chan et al, 1998, Christine F. Carson et al, 2002, Linda Halcon et al 2004), Candida albicans (S.D. Cox et al, 2000), Pseudomonas aeruginosa (S. Messager et al, 2005, Katgerine A. Hammer et al, 1996), Serratia marcescens, Klebsiella pneumoniae (Katherine A. Hammer et al. 1996)에 대한 항미생물 효과가 보고된 바 있으며, 또한, tea tree oil 은 onychomycosis(Buck DS et al, 1994), tinea pedis(Tong MM et al, 1992, Andrew C Satchell et al, 2002)), acne(Bassett IB et al, 1990), dandruff(Satchell AC et al, 2002)의 치료에 효과적임이 제안된 바 있다.Staphylococcus aureus (CH Chan et al., 1998, Christine F. Carson et al., 2002) was also used in this study. Klebsiella pneumoniae (Katherine A. Hammer et al., 2004), Candida albicans (SD Cox et al., 2000), Pseudomonas aeruginosa (S. Messager et al., 2005; Katgerine A. Hammer et al., 1996), Serratia marcescens, (Tong MM et al., 1992; Andrew C. Satchell et al., 2002)), the tea tree oil has been reported to be effective against onychomycosis (Buck DS et al, , acne (Bassett IB et al, 1990), and dandruff (Satchell AC et al, 2002).
특히, 피부사상균인 Trichophyton rubrum에 대한 항균활성은 평판배지를 이용한 항균활성(Steven Benger et al, 2004) 뿐만 아니라 vapour contact에 의한 항균활성(S. Inouye et al, 2001)도 보고되었다.In particular, the antimicrobial activity against Trichophyton rubrum, a dermatophytic strain, was reported not only by the antimicrobial activity using a plate medium (Steven Benger et al, 2004) but also by the vapour contact (S. Inouye et al, 2001).
티트리(Tea Tree) 나무는 피부질환에 잎의 추출물을 사용하여 왔든 것으로 항균작용이 우수하여 이 나무의 수증기법으로 오일을 취하여 식물성 천연 항균성 오일로 화장품 및 의약품으로 많이 사용되고 있다Tea Tree is a plant natural antimicrobial oil that has been used as a cosmetic and medicinal product because it has been used as an extract of leaves for skin diseases and has excellent antimicrobial action.
또한, 소금의 삼투압 작용은 피부의 묵은 각질은 물론 노폐물을 효과적으로 제거해 신진대사를 촉진시키고 혈액순환을 돕는다. 또한 살균, 소염의 효과가 있어 여드름이나 뾰루지 등의 발진을 완화시키는데 도움이 될 뿐만 아니라 피부의 수분을 잡아주어 뛰어난 보습효과를 주는 것으로 알려져 있다. 많이 섭취하면 몸에 해롭다고 흔히들 알고 있는 정제염이 아니라 죽염이나 사해소금 같은 미네랄이 풍부하고 입자가 고운 소금을 선별해 사용해야 한다. 입자가 굵은 천일염은 곱게 갈아 사용하는 것도 좋은 방법이다.In addition, the osmotic action of salt effectively removes dead skin as well as dead skin, promoting metabolism and helping blood circulation. It also has a sterilization and anti-inflammatory effect, which not only helps alleviate rashes such as acne and rash, but also gives moisture to the skin and gives it an excellent moisturizing effect. If you eat a lot of harmful to your body is not known to be a refined salt, such as bamboo salt and Dead Sea salt minerals rich and fine salt should be used to select. It is also a good idea to use fine-grained sun-dried salt.
따라서, 천연소금을 800℃ 이상의 고온으로 7 ~ 8 시간 동안 가열하면 소금 내의 모든 유해물질이 제거되고, 가열된 천연소금은 무기질 성분 및 미네랄 성분은 피부의 보습효과 및 피부의 재생에도 뛰어난 효과가 있고, 이를 본 발명의 티트리 추출물과 함께 사용하면 그 효능을 향상시키는 효과를 얻을 수 있다.Therefore, if the natural salt is heated at a high temperature of 800 ° C or more for 7 to 8 hours, all the harmful substances in the salt are removed, and the heated natural salt is excellent in the moisturizing effect of the skin and the regeneration of the skin, , And when it is used together with the tea tree extract of the present invention, the effect of improving the efficacy can be obtained.
본 발명은 천일염 천연소금 8%와 티트리 추출물이 함유된 보습료 화장료 조성물을 제시하고자 한다.
The present invention is to provide a moisturizing cosmetic composition containing 8% of natural salt of sun salted salt and tea tree extract.
본 발명에 있어서 티트리 추출물은 화장료 조성물의 유효성분으로 사용할 수 있으며, 바람직하게는 화장료 조성물로 이용할 수 있다. 티트리 조성물은 티트리 추출물을 0.1% 내지 10 중량%로 포함하는 것이다. In the present invention, tea tree extract can be used as an active ingredient of a cosmetic composition, and can be preferably used as a cosmetic composition. The tea tree composition contains 0.1% to 10% by weight of tea tree extract.
본 발명의 티트리 추출물은 티트리 잎으로 분류 한 후, 95% 에틸 알코올로 상온에서 2시간 동안 환류 추출한 시료와, 50 ℃로 2시간 동안 2회 환류 추출한 시료로 분류하여 이를 여과하여 감압농축 하였다. The tea tree extract of the present invention was classified into tea tree leaves and classified into a sample which was refluxed and extracted with 95% ethyl alcohol at room temperature for 2 hours and a sample which was refluxed twice at 50 ° C for 2 hours, followed by filtration and concentration under reduced pressure .
상기와 같이 수득한 티트리 추출물은 보습에 대한 Hyaluronic aid synthase(HaCaT)에 대한 항균활성이 매우 높아 화장료 조성물에 매우 효과적이다. 이에 본 발명은 보습 및 피부 개선에 효과가 있는 티트리 추출물 및 소금을 함유한 화장료 조성물에 관한 것이다. The tea tree extract thus obtained is highly effective in cosmetic compositions because of its high antibacterial activity against the hyaluronic aid synthase (HaCaT) for moisturizing. Accordingly, the present invention relates to a tea tree extract and a cosmetic composition containing salt which are effective for moisturizing and skin improvement.
상기 화장료 조성물에 포함되는 티트리 추출물 함량은 0.1% 내지 10 중량%가 바람직하며, 더욱 바람직하게는 0.1 내지 5 중량% 이다. 상기 함유량이 0.1 중량% 미만 일때는 항균효과가 미미하고, 10 중량%를 초과하는 경우에는 사용량에 따른 효과가 저하되는 문제점이 있다. The content of tea tree extract contained in the cosmetic composition is preferably from 0.1% to 10% by weight, more preferably from 0.1 to 5% by weight. When the content is less than 0.1% by weight, the antibacterial effect is insignificant. When the content is more than 10% by weight, there is a problem that the effect according to the usage amount is lowered.
상기 화장료 조성물은 일반 피부 화장료에 배합되는 보통의 성분, 예를들면 유분,물, 계면활성제, 보습제, 저급 알코올, 중점제, 킬레이트제, 색소, 향료 등을 필요한 만큼 적용 배합하는 것이 가능하다. The above-mentioned cosmetic composition can be blended with usual ingredients to be blended with common skin cosmetic ingredients such as oil, water, surfactant, humectant, lower alcohol, thickening agent, chelating agent, coloring matter, perfume and the like as necessary.
또한 상기 화장료 조성물은 피부에 사용하는 것으로서, 유연화장수(스킨), 수렴화장수, 영양화장수(로션), 영양크림, 맛사지크림, 에센스, 팩, 피부접착용 패취, 피부접착용 겔, 파우더, 비누, 서스펜션, 에멀젼, 스프레이 또는 미용약 등의 통상의 화장료 형태로 제조될 수 있다.
The cosmetic composition is used for the skin, and can be used for skin, cosmetic lotion, nutritional lotion, nutritional cream, massage cream, essence, pack, skin patch, skin adhesive gel, powder, soap, Suspension, emulsion, spray or cosmetics, and the like.
이하 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention.
첨부된 도 1은 본 발명의 티트리 잎부의 각 분획물을 제조하는 과정을 나타낸 도면이고, 도 2는 본 발명의 티트리 추출물 및 소금이 함유된 크림의 사용에 따른 수분손실률의 측정결과를 도시한 그래프이며, 도 3은 본 발명의 실시예에 따른 티트리 추출물 및 소금을 포함하는 화장료 조성물이 인체에 사용시 피부의 수분보유율의 시간 경과에 따라 측정결과를 도시한 그래프를 나타낸다.FIG. 1 is a view showing a process for producing the respective fractions of the tea tree leaf part of the present invention, and FIG. 2 is a graph showing the results of measurement of the water loss rate according to the use of the tea tree extract of the present invention and the cream containing the salt FIG. 3 is a graph showing the results of measurement of the moisture retention rate of skin when the cosmetic composition comprising tea tree extract and salt according to an embodiment of the present invention is applied to the human body over time.
그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐 본 발명이 하기의 실시예에 한정되는 것은 아니다.
However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited to the following examples.
실시예 1.Example 1.
1. 티트리 추출물 제조1. Tea tree extract preparation
티트리 잎을 건조, 분쇄하여 티트리 100g을 80%(v/v) 추출용매로 메탄올과 주정 에탄올을 사용하여 상온 추출법과 가온 추출법을 사용하여 표 1과 같이 4가지 종류의 추출물을 제조하였다.Tea tree leaves were dried and pulverized, and 100 g of tea tree was extracted with 80% (v / v) methanol and ethanol using room temperature extraction method and hot extraction method to prepare four kinds of extracts as shown in Table 1.
상온 추출은 시료를 용매에 72시간 동안 2회 침적하여 여과 후 농축하여 사용하였고, 가온 추출은 시료를 용매에 2시간 동안 50 ℃에서 2회 침적하여 추출한 후 여과 후 농축하여 사용하였다
For extraction at room temperature, the sample was immersed twice in a solvent for 72 hours, filtered and concentrated. The warm-up extraction was performed by extracting the sample twice at 50 ° C for 2 hours, filtering, and then concentrating
각 추출된 티트리 추출물의 보습 작용을 측정하기 위하여 Hyaluronic aid synthase(HaCaT) 세포는 Dulbecco's Modified EagleMedium (DMEM, Gibco)에 10% Fetal bovineserum (FBS, Gibco)과 1% penicillin-streptomycin(PS, Gibco)이 함유된 배지에서 37℃, 5% CO2 조건에서 배양하여 항균활성을 관찰하였다.Hyaluronic aid synthase (HaCaT) cells were treated with 10% fetal bovineserum (FBS, Gibco) and 1% penicillin-streptomycin (PS, Gibco) in Dulbecco's Modified EagleMedium (DMEM, Gibco) to determine the moisturizing effect of each extracted tea tree extract. Were cultured in a medium containing 5% CO 2 at 37 ° C to observe the antimicrobial activity.
본 연구에 대한 항균활성은 표 1, 2에 나타내었다. The antimicrobial activity for this study is shown in Tables 1 and 2.
잎
leaf
Methanol
Ethanol in alcohol
잎부
Leaf part
- :균의 성장을 억제하지 못함-: Does not inhibit growth of bacteria
+ : colony 100개 이상으로 성장+: grow to over 100 colony
++ : colony 1 - 100개 성장++: colony 1 - Grow 100
+++ : colony 성장을 100% 억제+++: 100% inhibition of colony growth
실시예 2.Example 2.
티트리 추출물의 Minimum inhibitory concentration(MIC) 결정Determination of minimum inhibitory concentration (MIC) of tea tree extract
상기 실시예 1에서 추출한 티트리무 추출물 중 항균활성이 우수한 1번과 3번의 항염증 작용을 측정하기 위하여 배양된 세포 Hyaluronic aid synthase(HaCaT) 배지에 최종균 농도가 10 5 CFU/㎖가 되도록 접종하였다. In order to measure the anti-inflammatory effects of the first and third anti-inflammatory activities of the tea tree extract obtained in Example 1, the cells were inoculated in a culture medium of Hyaluronic aid synthase (HaCaT) to a final bacterial concentration of 10 5 CFU / ml .
이를 microdilution 법으로 티트리 추출물 1번과 3번을 처리하여 32℃에서 48 시간 동안 배양한 후, 균들의 성장과 비성장을 육안으로 관찰하여 성장이 억제된 최소농도를 최소 억제농도(MIC)로 결정하고, 그 결과를 하기 표 3에 나타내었다.After incubation at 32 ° C for 48 hours, microbial growth and non-growth of microorganisms were observed by microdilution method and the minimum inhibitory concentration (MIC) And the results are shown in Table 3 below.
티트리 잎 추출물
Tea tree leaf extract
- :균의 성장을 억제하지 못함-: Does not inhibit growth of bacteria
+ : colony 100개 이상으로 성장+: grow to over 100 colony
++ : colony 1 - 100개 성장++: colony 1 - Grow 100
+++ : colony 성장을 100% 억제
+++: 100% inhibition of colony growth
상기 표 3의 결과로 티트리 잎부 추출물의 Hyaluronic aid synthase(HaCaT)에 대한 MIC는 각각 0.5%임을 확인하였다.As a result of the above Table 3, it was confirmed that the MIC for the hyaluronic aid synthase (HaCaT) of the tea tree leaf extract was 0.5%, respectively.
상기 표 3의 티트리 잎부의 추출물을 각 0.5% 투여시 상기 활성된 균 성장이 100% 억제된 것을 볼 수가 있다.
It can be seen that when the 0.5% extract of the tea tree leaf part of Table 3 is administered, the active bacteria growth is inhibited by 100%.
실시예 3. Example 3.
티트리 잎부의 분획물 제조 및 항균활성Fractionation and antibacterial activity of tea tree leaf
상기 실시예 1, 실시예 2에서 추출한 티트리 추출물 중 항균활성이 우수한 3번을 각 용매 n-Hexane, CHCl3, EtOAc, Residue로 순차 추출 후 분획물을 제조하였다. Fractions 3 were sequentially extracted from the tea tree extracts obtained in Example 1 and Example 2, respectively, into n-hexane, CHCl 3 , EtOAc and residues.
즉, 첨부된 도 1에 제시된 바와 같이 본 발명의 티트리 잎부는 주정 상온 추출을 통하여 잎부 추출물을 제조 후, 추출물을 각 용매 n-hexane(1-1), CHCl3(1-2), EtOAc(1-3), Residue(1-4)로 순차 추출 후 분획물을 제조하였다. That is, as shown in FIG. 1, the tea tree leaf part of the present invention was prepared by extracting leaves with a solvent at room temperature, and then the extract was dissolved in each solvent n-hexane (1-1), CHCl 3 (1-2), EtOAc (1-3) and Residue (1-4).
상기와 같이 분획된 추출물의 각 티트리 잎부의 항염증 작용을 측정하기 위하여 Hyaluronic aid synthase(HaCaT) 배지에 최종균 농도가 10 5 CFU/㎖가 되도록 접종하였다. 접종된 각 균주는 0.9% 농도의 각 분획물을 처리하여 32℃에서 48 시간 동안 배양한 후, 균들의 성장과 비 성장을 육안으로 관찰하였다.In order to measure the anti-inflammatory activity of each tea tree leaf part of the thus-extracted extract, the seeds were inoculated to a hyaluronic aid synthase (HaCaT) medium to have a final bacterial concentration of 10 5 CFU / ml. Each of the inoculated strains was treated with 0.9% of each fraction and cultured at 32 ° C for 48 hours. The growth and non - growth of the bacteria were visually observed.
본 발명에 대한 상세한 설명은 표 4에 나타내었다.
The details of the present invention are shown in Table 4.
- :균의 성장을 억제하지 못함-: Does not inhibit growth of bacteria
+ : colony 100개 이상으로 성장+: grow to over 100 colony
++ : colony 1 - 100개 성장++: colony 1 - Grow 100
+++ : colony 성장을 100% 억제+++: 100% inhibition of colony growth
상기의 티트리 잎부 추출물은 Hyaluronic aid synthase(HaCaT) 배지에 대해 항균활성이 있음을 알 수 있다.
The above tea tree leaf extract has antimicrobial activity against the hyaluronic aid synthase (HaCaT) medium.
본 발명에 따른 티트리 추출물 및 소금이 함유된 화장료 조성물은 보습용 크림, 화장수(스킨, 로션), 젤, 폼, 파우더, 바디워시, 스크럽 삼푸, 마사지 크림 등의 사용 목적이나 용도에 맞게 적절한 형태로 만들어 세안, 목욕, 세발, 피부 마사지 등의 다양한 용도로 사용할 수 있다.
The tea tree extract and the cosmetic composition containing the salt according to the present invention can be suitably used for the purpose or use of the moisturizing cream, the skin lotion, the gel, the foam, the powder, the body wash, the scrub shampoo, It can be used for a variety of purposes such as cleansing, bathing, hair removal, and skin massage.
실시예 4. 피부 보습제용 화장료 조성물Example 4. Cosmetic composition for skin moisturizer
상기 표 5에 나타낸 조성에 따라 정제수, 보습제, 계면활성제, 방부제, 점증제, 향료, 구운소금, 티트리 추출물을 각각 계량한 다음, 수상 성분과 유상 성분 및 첨가 성분으로 분류하여 각기 특성에 따라 용해시킨 후 수상 성분과 유상 성분을 믹스기를 이용하여 2500rpm으로 78℃를 유지시키면서 10분간 교반 하다가 55℃에서 첨가 성분을 투입한 후 약 5분간 더 교반한 다음, 40℃까지 냉각시켜 본 발명에 따른 티트리 추출물 및 소금을 포함하는 피부 보습용 화장료 조성물을 제조하였다.
The purified water, moisturizing agent, surfactant, preservative, thickener, fragrance, baked salt and tea tree extract were respectively weighed according to the composition shown in the above Table 5, and classified into a water phase component, an oil phase component and an additive component, And then the aqueous phase component and the water phase component were stirred at 25 ° C. for 10 minutes while maintaining 78 ° C. at 2500 rpm using a mixing machine. Then, the components were added at 55 ° C. and stirred for about 5 minutes, and then cooled to 40 ° C. A tree extract and a salt were prepared.
이하에서는 상기 조성에 따른 피부 보습용 화장료에 대하여 피부 자극성 검사 및 보습력 평가를 실시하여 그 결과를 표로 표시하였다.Hereinafter, the skin-moisturizing cosmetic according to the above composition was subjected to a skin irritation test and an evaluation of moisturizing ability, and the results were tabulated.
상기에 의해 제조된 보습료 크림을 성인 남녀 50명에게 온수의 물로서 얼굴에 세수한 후 3분 후 자극시험을 하고 2차 실험은 30분 후 자극 테스트하였으며 3차 실험은 매일 아침, 저녁 2회 실시하여 10일 후에 자극시험, 4차 실험은 매일 아침, 저녁 2회 30일 후 자극시험을 실시하였다.The moisturizing cream cream prepared by the above method was applied to 50 adult men and women as water of hot water, and then stimulated after 3 minutes. The second experiment was stimulated 30 minutes later. The stimulation test was performed 10 days later and the fourth test was conducted every morning and two
* 피부 반응도 산출 공식은 = 반응치 X 반응 사람 수* Skin response calculation formula = response value X response person number
* 평균 반응도 = (1차 반응치 x 반응 수 + 2차 반응치 x 반응 수 + 3차 반응치 x 반응 수 + 4차 반응치 x 반응 수) / 종합반응 참가자 수 평균 반응도를 계산하여 표 7의 평균반응에 따른 판정기준을 산정하여 표 8의 판정기준에 따라 자극의 정도를 나타내었다.
* Average Reaction Rate = (First Reaction Value x Reaction Number + Second Reaction Value x Reaction Number + Third Reaction Value x Reaction Number + Fourth Reaction Value x Reaction Number) The criteria for the average response were calculated and the degree of stimulation was shown according to the criteria in Table 8.
표 7의 평균 판정기준에 따른 반응도(표8) 결과에 의해 평균반응도 값이 최고 0.006 이하이므로 피부 무자극이었다.
The results of the responses according to the average judgment criteria in Table 7 (Table 8) indicate that skin irritation was caused by the average response value of 0.006 or less.
<보습력 평가><Moisture power evaluation>
피험자들을 대상으로 본 발명에 따른 티트리 추출물 및 소금이 포함된 보습용 화장료 조성물의 보습력을 다음과 같이 평가하였다. 여기서, 보습력은 각질층의 수분보유량을 의미한다.The moisturizing power of the tea tree extract and the moisturizing cosmetic composition containing the salt according to the present invention was evaluated as follows. Here, the moisturizing power means the moisture holding amount of the stratum corneum.
피험자의 팔 안쪽 5cm×5cm 부위에 각 시료를 도포한 후 1분간 문지른 다음 약 30초 후에 흐르는 물에 약 10초간 씻었다. 1일 4시간 간격으로 2회 실시한 후 수분보유량을 측정하였으며, 그 결과를 하기의 표 9 및 도 2에 나타내었다. 이때, 측정기는 Corneometer CM 825(Courage + Khazaka 사, 독일)를 이용하였고, 시험은 25℃, 상대습도 50%의 항온 항습실에서 15, 30, 60, 120분 간격으로 실시하였다.Each sample was applied to a 5 cm x 5 cm area inside the subject's arm, rubbed for 1 minute, and then rinsed for about 10 seconds in flowing water about 30 seconds later. The water content was measured twice after being carried out at intervals of 4 hours per day, and the results are shown in Table 9 and FIG. 2 below. The test was carried out at 15, 30, 60, and 120 minutes in a constant temperature and humidity chamber at 25 ° C and a relative humidity of 50%, using a Corneometer CM 825 (Courage + Khazaka, Germany).
여기서, 본 발명에 따른 화장료 조성물의 대조군은 피험자의 팔 안쪽 5cm×5cm 부위를 흐르는 물에 약 10초간 씻은 다음 수분보유량을 측정하여 그 결과를 나타낸 것이다.
Herein, the control group of the cosmetic composition according to the present invention was washed with water flowing in a region of 5 cm x 5 cm inside the arm of the subject for about 10 seconds, and moisture content was measured.
상기 표 9 및 도 2 및 도 3에 도시된 바와 같이, 본 발명에 따른 티트리 추출물 및 소금이 포함된 화장료 조성물이 대조군에 비하여 수분보유율이 매우 높음을 확인할 수 있다.
As shown in Table 9, FIG. 2 and FIG. 3, it can be seen that the tea tree extract according to the present invention and the cosmetic composition containing the salt have a much higher moisture retention than the control group.
이하, 본 발명의 제형예로서 유연화장수(스킨), 영양화장수(로션), 에센스, 영양크림, 마사지 크림, 팩, 센안제(클렌징 폼), 비누제를 예시하고 있으나, 본 발명의 화장료 조성물을 포함하는 제형은 이에 한정되는 것은 아니다.
Hereinafter, the formulation of the present invention is exemplified by a softening longevity (skin), a nutritional lotion (lotion), an essence, a nutritive cream, a massage cream, a pack, a sensitizer (cleansing foam) The formulations that comprise are not so limited.
제형제 1. 유연 화장수(스킨)
Brother 1. Flexible lotion (skin)
본 발명의 티트리 추출물 및 소금을 포함하는 피부용 유연 화장수를 제조하기 위해 하기 표 10에 기재된 것처럼 배합하여 통상적인 화장품 분야에서의 제조 방법에 따라 제조할 수 있다.To prepare a skin lotion for skin comprising the tea tree extract of the present invention and salt, it may be formulated as described in Table 10 below and may be manufactured according to a conventional manufacturing method in the field of cosmetics.
제형예 2. 영양 화장수(로션)Formulation Example 2. Nourishing lotion (lotion)
본 발명의 티트리 추출물 및 소금을 포함하는 피부용 유연 화장수를 제조하기 위해 하기 표 11에 기재된 것처럼 배합하여 통상적인 화장품 분야에서의 제조 방법에 따라 제조할 수 있다.To prepare a skin lotion for skin comprising the tea tree extract of the present invention and salt, it may be formulated as described in Table 11 below and may be manufactured according to a conventional manufacturing method in the field of cosmetics.
제형예 3. 에센스Formulation Example 3. Essence
본 발명의 티트리 추출물 및 소금을 포함하는 피부용 에센스를 제조하기 위해 하기 표 12에 기재된 것처럼 배합하여 통상적인 화장품 분야에서의 제조 방법에 따라 제조할 수 있다.To prepare essences for skin comprising the tea tree extract of the present invention and salt, as described in Table 12 below, they can be manufactured according to a conventional manufacturing method in the field of cosmetics.
제형예 4. 세안제(클렌징 폼)Formulation Example 4. Cleanser (cleansing foam)
본 발명의 티트리 추출물 및 소금을 포함하는 피부용 세안제(클렌징 폼)를 제조하기 위해 하기 표 13에 기재된 것처럼 배합하여 통상적인 화장품 분야에서의 제조 방법에 따라 제조할 수 있다.To prepare a skin cleanser (cleansing foam) containing the tea tree extract of the present invention and salt, it may be formulated as described in Table 13 below and may be manufactured according to a conventional manufacturing method in the field of cosmetics.
이상, 본 발명의 구체적인 실시예를 통하여 상세하게 설명하였으나, 여기서 특정하게 사용된 용어들은 단지 본 발명을 설명하기 위한 목적에서 사용되는 것이지 의미 한정이나 특허등록청구범위에 기재된 본 발명의 범위를 제한하기 위하여 사용된 것은 아니다. 그러므로 본 기술 분야의 통상의 지식을 가진 자라면 이로부터 다양한 변형 및 균등한 타 실시예로 여러 가지 변형이 가능하다.While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. It is not used for. Therefore, those skilled in the art will appreciate that various modifications and equivalent arrangements may be made therein without departing from the scope of the present invention.
Claims (3)
A cosmetic composition comprising tea tree leaf extract and salt, characterized in that skin moisturization is maintained by the production of hyaluronic acid (HA) in hyaluronic aid synthase (HaCaT) cells as an effective ingredient of tea tree leaf extract and salt.
상기 티트리 잎부는 n-Hexane, CHCl3 또는 EtOAc 용매를 이용하여 추출한 추출물과 이를 용매를 이용하여 순차적으로 추출한 분획물을 포함하는 것을 특징으로 하는 예덕나무 추출물을 포함하는 화장료 조성물
The method according to claim 1,
Wherein the tea tree leaf part comprises an extract obtained by extracting with n-hexane, CHCl 3 or EtOAc solvent and a fraction obtained by sequentially extracting it with a solvent.
상기 티트리 잎 추출물이 유효성분으로 조성물 전체 중량에 대하여 0.1 내지 10 중량%을 함유하고, 구운 소금을 8 중량% 함유하여 유연화장수(스킨), 수렴화장수, 영양화장수(로션), 영양크림, 맛사지크림, 세안제 또는 에센스의 혼합물인 것을 특징으로 하는 티트리 잎부 추출물과 소금을 포함하는 화장료 조성물.3. The method according to any one of claims 1 to 3,
Wherein the tea tree leaf extract contains 0.1 to 10% by weight based on the total weight of the composition as an active ingredient and contains baked salt in an amount of 8% by weight and contains softening longevity (skin), convergent lotion, nutritional lotion (lotion) A cosmetic composition comprising a tea tree leaf extract and a salt, wherein the tea tree leaf extract is a mixture of a cream, a cleanser and an essence.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020140041090A KR20150116504A (en) | 2014-04-07 | 2014-04-07 | A cosmetics composition containing tea tree and solt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020140041090A KR20150116504A (en) | 2014-04-07 | 2014-04-07 | A cosmetics composition containing tea tree and solt |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20150116504A true KR20150116504A (en) | 2015-10-16 |
Family
ID=54365523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020140041090A KR20150116504A (en) | 2014-04-07 | 2014-04-07 | A cosmetics composition containing tea tree and solt |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR20150116504A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190027641A (en) | 2017-09-07 | 2019-03-15 | 주식회사 래디안 | Natural antibacterial agent and manufacturing method thereof |
KR102342695B1 (en) | 2021-07-14 | 2021-12-24 | 에이드코리아컴퍼니 주식회사 | Cosmetic composition for skin soothing |
CN118105324A (en) * | 2024-03-05 | 2024-05-31 | 广州市碧颜化妆品有限公司 | Whitening antibacterial toothpaste and preparation method thereof |
-
2014
- 2014-04-07 KR KR1020140041090A patent/KR20150116504A/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190027641A (en) | 2017-09-07 | 2019-03-15 | 주식회사 래디안 | Natural antibacterial agent and manufacturing method thereof |
KR102342695B1 (en) | 2021-07-14 | 2021-12-24 | 에이드코리아컴퍼니 주식회사 | Cosmetic composition for skin soothing |
CN118105324A (en) * | 2024-03-05 | 2024-05-31 | 广州市碧颜化妆品有限公司 | Whitening antibacterial toothpaste and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPWO2004016236A1 (en) | Cosmetics | |
JP2000128730A (en) | Cosmetic composition containing moisture-retaining plant extract | |
CN109998937B (en) | Cosmetic series containing glycerol glucoside (alpha GG) and preparation method thereof | |
JP5758174B2 (en) | Antioxidants and antioxidant cosmetics | |
CA2882392C (en) | Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne | |
KR20180069756A (en) | Cosmetic Composition for comprising longanae arillus extracts | |
KR20080053614A (en) | Composition comprising lava seawater salt | |
KR102220534B1 (en) | Soothing cream and manufacturing method for the same | |
KR20160119967A (en) | Cosmetic composition comprising echinacea purpurea extract | |
JP2020502172A (en) | Cosmetic composition containing Chinese herbal extract as active ingredient | |
CN103494737A (en) | Cosmetic preparation using ginger flower as anti-ageing and skin-protecting factor and preparation method of cosmetic preparation | |
KR20150116504A (en) | A cosmetics composition containing tea tree and solt | |
MX2014005713A (en) | Compositions comprising extracts of bursera simaruba. | |
KR100979143B1 (en) | Cosmetic composition containing herb extract for skin moisturizing effect and for enhancing skin elasticity | |
CN118236288A (en) | Sun-proof skin care product and preparation method thereof | |
KR20210072966A (en) | Nanocapsule composition for skin moisturizing or skin inflammatory improvement comprsing encapsulated centella and calamine | |
FR3034667A1 (en) | COSMETIC AND / OR DERMATOLOGICAL COMPOSITION AGAINST ACNE | |
KR101736478B1 (en) | Method for manufacturing lotions with effective in treating acne | |
KR101922089B1 (en) | Cosmetic Composition for comprising longanae arillus extracts | |
KR101876744B1 (en) | A step 3 method for improving skin condition using cosmetic composition comprising a ginseng extract | |
KR20070065926A (en) | Composition comprising green tea extract and brassica olecea var. botrytis extract having anti-biotic, deodorante and the use thereof | |
KR20190021114A (en) | Composition for anti-inflammation, inhibiting secretion of sebum, or treating acne on the skin comprising plant extract | |
KR20090075281A (en) | Cosmetic composition with the effect of atopy skins | |
KR20180082058A (en) | A cosmetic composition for skin desquamation comprising natural complex extract | |
JPH10175814A (en) | Skin preparation for external use and bathing agent containing garcinia extract |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 20140407 |
|
PA0201 | Request for examination | ||
PG1501 | Laying open of application | ||
E902 | Notification of reason for refusal | ||
PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20160107 Patent event code: PE09021S01D |
|
E601 | Decision to refuse application | ||
PE0601 | Decision on rejection of patent |
Patent event date: 20160627 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20160107 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |