CN115813840A - Children soothing gel containing oat extract and preparation method thereof - Google Patents
Children soothing gel containing oat extract and preparation method thereof Download PDFInfo
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- CN115813840A CN115813840A CN202211682354.XA CN202211682354A CN115813840A CN 115813840 A CN115813840 A CN 115813840A CN 202211682354 A CN202211682354 A CN 202211682354A CN 115813840 A CN115813840 A CN 115813840A
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- 238000000605 extraction Methods 0.000 title description 2
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 239000002904 solvent Substances 0.000 claims abstract description 9
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 8
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 8
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
- 239000002562 thickening agent Substances 0.000 claims abstract description 6
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- 239000001841 zingiber officinale Substances 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
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- 238000000034 method Methods 0.000 claims description 7
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 claims description 6
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 claims description 6
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- 238000003756 stirring Methods 0.000 claims description 5
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- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
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- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
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- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 2
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- 206010040914 Skin reaction Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
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- 229940002508 ginger extract Drugs 0.000 description 1
- 235000020708 ginger extract Nutrition 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
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- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000008368 mint flavor Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
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- 231100000430 skin reaction Toxicity 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
A children soothing gel containing oat extract is characterized by comprising the following raw materials in percentage by weight of the total weight of the aqueous gel: 0.1 to 3 percent of oat conditioner, 0.01 to 1 percent of bisabolol conditioner, 0.01 to 1 percent of ginger root conditioner, 0.01 to 0.5 percent of pH regulator, 0.01 to 1 percent of aromatic, 0.01 to 1 percent of thickening agent and 30 to 80 percent of solvent; a preparation method of children soothing gel containing oat extract comprises the following steps: comprises putting the raw materials into a proper container according to the proportion, and controlling the temperature to be 90-100 ℃ under the heating condition. The invention has the advantages that: a skin conditioner derived from herba Avenae Fatuae is combined with skin conditioners derived from multiple plants as soothing component, contains a certain amount of ethanol component, etc., and has effects of refreshing and refreshing body and relieving.
Description
Technical Field
The invention relates to a mild and safe gel-like care product with a soothing effect on children skin and low irritation on skin, in particular to a children soothing gel containing oat extract.
Background
The skin is the largest organ of the human body, after the child is born, the delicate skin does not develop completely, and the skin can develop and mature gradually after 3 years in a big summary. The skin of children is different from the skin of adults in structure and function, the skin of children is smooth, tender and unclear in texture, sebum secretion is less, intercellular lipid is soft, the resistance to external physical, chemical, mechanical and biological invasion is weak, and skin problems are easily caused. For example, the skin is not moist enough, and is easy to dry, desquamate, pruritus and rubefaction; the weak defense force of the skin causes the pathogenic bacteria to easily invade the skin, and causes diseases such as atopic dermatitis, eczema and the like.
The glucocorticoid product can effectively relieve various skin diseases of babies, the topical glucocorticoid product is still a nursing product which can be used for setting the pole to take effect in the current market, although the product can effectively control symptoms, the side effect is large, the product can cause certain damage to the fragile skin of the babies, and the product is easy to cause certain degree of dependence after long-term use. The delicate skin of the children needs careful care of mothers, it is very important to select a correct nursing product, and a healthy and non-irritant anti-allergy nursing product special for the children needs to be selected to care the delicate skin of the children. The soothing nursing product is natural and mild, has a refreshing and cool effect, is particularly suitable for the sensitive skin of children, and can relieve the skin discomfort of the children caused by dry weather or mosquito bite. The natural herbal components of the plant source are extracted, so that the skin barrier effect of the baby can be enhanced, the skin micro-ecosystem can be conditioned, and the damaged skin can be assisted to be repaired. In recent years, care products containing plant sources are increasingly favored by young mothers.
Disclosure of Invention
The skin care product aims to solve the problems that the skin care product has large side effect, can cause certain damage to the fragile skin of a baby, and is easy to cause certain degree of dependence after long-term use. The invention aims to provide a children soothing gel containing oat extract and a preparation method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a children soothing gel containing oat extract is characterized by comprising the following raw materials in percentage by weight of the total weight of the aqueous gel: 0.1 to 3 percent of oat conditioner, 0.01 to 1 percent of bisabolol conditioner, 0.01 to 1 percent of ginger root conditioner, 0.01 to 0.5 percent of pH regulator, 0.01 to 1 percent of aromatic, 0.01 to 1 percent of thickening agent and 30 to 80 percent of solvent;
preferably, the oat conditioning agent is selected from butanediol, 1, 2-pentanediol and hydroxyphenylpropionamide benzoic acid, wherein the hydroxyphenylpropionamide benzoic acid is an active ingredient derived from cereal oat seeds, and the hydroxyphenylpropionamide benzoic acid has rapid anti-inflammatory and antipruritic activities;
the bisabolol conditioner is extracted from chrysanthemum plants, has the functions of anti-inflammation and bacteriostasis, has good stability and good compatibility with skin, reduces skin inflammation, relieves skin acne, prevents pimples, improves the anti-irritation capacity of the skin, repairs the skin with inflammation injury, and improves the SPF value in a sun-proof product;
the ginger root conditioner adopts a ginger root extract, and the main active substances are gingerol and gingerol; the ginger extract has obvious inhibition effect on staphylococcus aureus, staphylococcus albus, typhoid bacillus, dysentery bacillus sonnei and pseudomonas aeruginosa;
arginine is selected as the pH regulator;
the aromatic agent is herbal essence;
the thickening agent is carbomer;
the solvent is 95% food grade alcohol.
A preparation method of children soothing gel containing oat extract comprises the following steps: the raw materials are put into a proper container according to the proportion, water and carbomer are pumped into the container, then stirring is started, the temperature is controlled to be 90-100 ℃ under the heating condition, the raw materials are stirred, dissolved and mixed uniformly, then the rest raw materials are added one by one, and the last raw material is stirred, dissolved and mixed uniformly before each raw material is added.
Preferably, the preparation vessel may employ any conventional mixing apparatus well known in the art, such as: stirred pots, and the like.
The invention has the advantages that: a skin conditioner derived from herba Avenae Fatuae is combined with skin conditioners derived from multiple plants as soothing component, contains a certain amount of ethanol component, etc., and has effects of refreshing and refreshing body and relieving.
Detailed Description
A children soothing gel containing oat extract is prepared from the raw materials, and deionized water.
Example 1
The raw materials are prepared according to the following proportion
Example 2
The raw materials are prepared according to the following proportion:
example 3
Preparing raw materials according to the following proportion:
raw material name raw material percentage action
95% food grade alcohol 50% solvent
(hydroxyphenylpropionamide benzoic acid,
Butanediol, 1, 2-pentanediol) 1.8% skin conditioner
Bisabolol 0.15% skin conditioner
Ginger root extract 0.05% skin conditioner
Carbomer 0.2% thickening agent
Arginine 0.05% pH regulator
Deionized Water to 100% solvent
Mint flavor 0.1% aromatic
Test for soothing efficacy
Principle of testing
Hyaluronidase is a specific lyase of hyaluronic acid, is a participant in allergic reactions, and has a strong correlation with histamine release from mast cells, and the like. Whether the test sample has the effect of relieving can be judged by using the hyaluronidase inhibition rate, and the higher the hyaluronidase inhibition rate is, the stronger the effect of relieving without the substance is reflected, and otherwise, the weaker the effect is.
According to the test method, the hyaluronidase inhibition test results of the samples are compared with those of the negative control, and if the inhibition rate of the test sample is higher than that of the negative control and has significant difference (p is less than 0.05), the test sample can be considered to have certain relieving efficacy.
The test indexes are shown in Table 1
TABLE 1 test indexes
Test materials and methods:
the instrument equipment comprises:
BSA224S analytical balance
L6s ultraviolet spectrophotometer
Reagent:
(ii) a hyaluronidase enzyme(s),
the sodium hyaluronate of BR is prepared by the steps of,
BR dipotassium glycyrrhizinate with the purity not less than 98 percent
The test method comprises the following steps:
(1) Treatment of controls and test samples
Example samples;
positive control (dipotassium glycyrrhizinate, purity > 98%): diluting with water to reach a positive control concentration of 3%;
negative control: pure water.
(2) Procedure for testing
Setting up sample group, sample background group, solvent group and solvent background group, wherein each group needs 3 parallels, adding different reagent solutions into four groups, shaking, standing at room temperature for 30min for color development, and measuring absorbance value at 528nm with ultraviolet spectrophotometer.
(3) Formula for calculation
In the formula: a-is the absorbance of the reaction solution without the sample;
b-is the absorbance of the reaction solution without sample and enzyme;
c-is the absorbance of the reaction solution containing the sample and the enzyme;
d-is the absorbance of the reaction solution containing the sample and no enzyme.
(4) Data analysis
The statistical analysis software was SPSS, and the comparison between hyaluronidase inhibition for test samples, positive controls and negative controls was performed using independent sample t-tests. The above statistical analyses were all two-tailed tests with significance level α =0.05.P >0.05, indicating no significant difference between the two groups; p <0.05, indicating significant differences between the two groups.
The test results are shown in table 2:
TABLE 2 results of the soothing efficacy test
Note: hyaluronidase inhibition was maintained at three decimal places, p <0.05, indicating significant differences between samples and positive controls.
As can be seen from table 2, the children's aqueous gel containing an oat composition having soothing effect according to the present invention has an inhibitory effect on hyaluronidase, and example 3 is superior to examples 1 and 2, it can be seen that soothing effect increases with the increase of the addition amount of the oat composition, and when used in combination with bisabolol and ginger root extract, the oat composition and the bisabolol ginger root extract can be reduced in the use amount of each, and the reduction of the addition amount of the raw materials can reduce the production cost, so that example 3 is preferred in the present invention. The specific production process comprises the following steps:
pumping water and carbomer into the stirring kettle, stirring, dissolving, mixing, adding the rest materials one by one, and stirring, dissolving and mixing the above materials before adding each material.
Skin irritation test
The specific methods and results are as follows:
the test substance:
the test substance in this test was an aqueous child gel containing an oat composition with soothing effect, without dissolution and without dilution.
Experimental animals and breeding environment:
4 common-grade white New Zealand rabbits weight 2.49-2.51kg. Provided by suzhou lake bridge biotechnology limited, laboratory animal production licenses: SCXK (su) 2020-0001, quality certification number: 202214716. the temperature of the laboratory animal feeding room is 19-21 ℃, the relative humidity is 41-49%, and the use license number of the laboratory animal is as follows: SYXK (Su) 2020-0011. The rabbit feed is provided by Laiwukang big feed Co., ltd, and the feed production license number is as follows: shanghai feeding (2019) 12004, feed quality certification number: 20220303001.
multiple skin irritation test procedures:
approximately 24 hours before the test, the hairs on two sides of the spine of the rabbit are cut off, the hair removing range is approximately 3cm multiplied by 3cm on the left side and the right side respectively, and the smearing area is 2.5cm multiplied by 2.5cm. For the test, 0.5mL of the test substance was applied evenly to the right depilated skin and the left skin was treated with water as a control. The application is carried out once a day for 14 days. Shearing hair before applying the skin cream every day from the next day, removing residual test substances by using warm water, observing skin reaction after one hour, grading the skin stimulation reaction according to skin stimulation reaction grading of chapter 4 of technical Specification for safety of cosmetics (2015 edition), 3, respectively calculating the integral mean value of each animal for 14 days and the integral mean value of each animal every day after the test is finished, and grading the skin stimulation intensity according to the skin stimulation intensity of table 4.
TABLE 3 skin irritation response score
And (4) evaluating the results: the average integral per animal per day was calculated according to the following formula, and the skin irritation intensity was determined as shown in Table 4. The test results are shown in Table 5.
Table 4 skin irritation intensity grading
TABLE 5 test results
It can be seen that the child soothing lotion is non-irritating to the skin.
In conclusion, the children soothing gel containing the oat extract component has a good soothing effect, and is mild, safe and non-irritant.
The invention and its embodiments have been described above, without this being limitative. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (4)
1. A children soothing gel containing oat extract is characterized by comprising the following raw materials in percentage by weight of the total weight of the aqueous gel: 0.1 to 3 percent of oat conditioner, 0.01 to 1 percent of bisabolol conditioner, 0.01 to 1 percent of ginger root conditioner, 0.01 to 0.5 percent of pH regulator, 0.01 to 1 percent of aromatic, 0.01 to 1 percent of thickening agent and 30 to 80 percent of solvent.
2. The children's soothing gel containing oat extract according to claim 1, wherein the oat extract comprises:
the oat conditioner is a composition of butanediol, 1, 2-pentanediol and hydroxyphenylpropionamide benzoic acid, wherein the hydroxyphenylpropionamide benzoic acid is an active ingredient from cereal oat seeds;
the bisabolol conditioner is extracted from chrysanthemum plants;
the ginger root conditioner is prepared from a ginger root extract;
arginine is selected as the pH regulator;
the aromatic agent is herbal essence;
the thickening agent is ginger root extract;
the solvent is 95% food grade alcohol.
3. The method of preparing a children's soothing gel containing oat extract according to claim 1, wherein the method comprises the following steps: the raw materials are put into a proper container according to the proportion, water and carbomer are pumped into the container, then stirring is started, the temperature is controlled to be 90-100 ℃ under the heating condition, the raw materials are stirred, dissolved and mixed uniformly, then the rest raw materials are added one by one, and the last raw material is stirred, dissolved and mixed uniformly before each raw material is added.
4. The method of preparing a children's soothing gel containing oat extract component according to claim 3, wherein the method comprises the following steps: the preparation vessel may employ any conventional mixing equipment well known in the art, such as: stirred pots, and the like.
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|---|---|---|---|---|
| CN110090190A (en) * | 2019-05-22 | 2019-08-06 | 中山爱护日用品有限公司 | A kind of baby child plant is releived refrigerant liquid and preparation method thereof |
| CN114073657A (en) * | 2021-11-17 | 2022-02-22 | 广州市添姿彩精细化工有限公司 | Multi-effect cream for infants and preparation method thereof |
| CN114983910A (en) * | 2022-07-21 | 2022-09-02 | 福建省梦娇兰日用化学品有限公司 | Soothing and repairing type children sunscreen cream and preparation method thereof |
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- 2022-12-27 CN CN202211682354.XA patent/CN115813840A/en active Pending
Patent Citations (3)
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| CN110090190A (en) * | 2019-05-22 | 2019-08-06 | 中山爱护日用品有限公司 | A kind of baby child plant is releived refrigerant liquid and preparation method thereof |
| CN114073657A (en) * | 2021-11-17 | 2022-02-22 | 广州市添姿彩精细化工有限公司 | Multi-effect cream for infants and preparation method thereof |
| CN114983910A (en) * | 2022-07-21 | 2022-09-02 | 福建省梦娇兰日用化学品有限公司 | Soothing and repairing type children sunscreen cream and preparation method thereof |
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| 福建省梦娇兰日用化学品有限公司: "小浣熊植萃舒缓冰露", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=917792929186054144&gb=G> * |
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