KR20100039532A - Hydrogel composition for healing atopy and matrix patch for healing atopy using the hydrogel composition as a matrix - Google Patents

Abstract

PURPOSE: A matrix patch using a hydrogel composition is provided to prevent moisture loss in the skin and to prevent and relieve atopy. CONSTITUTION: A hydrogel composition for treating atopy contains Pseudoceramide, cerix 5, cerasol, moistin, morus bark extract, Oenothera odorata seed oil, jojoba oil, olive oil, Elhibin or Stimutex AS first raw material, Scutellaria baicallensis Georgi extract, Pleuropterus mulflorus extract, chamomile extract, or dismutin BT second raw material, Phytospingosine, Atofree, or Lipacide UG third raw ingredient. The hydrogel composition further contains carrageenan or locust bean gum. The hydrogel is water soluble hydrogel.

Description

Hydrogel Composition for Healing Atopy and Matrix Patch for Healing Atopy Using the Hydrogel Composition as a Matrix}

The present invention relates to a hydrogel composition and a matrix patch using the same as a matrix, and more particularly, to a hydrogel composition for treating atopy and a matrix patch using the same as a matrix.

Atopy is the name of 'natural insensitivity' in 1925 to the 'Coca' of the United States of certain kinds of human beings. Allergic diseases, including atopic dermatitis, allergic asthma and rhinitis, affect more than 20% of the world's population, especially in developing countries.

In particular, there are more than 50 million allergic patients in the United States alone, and the market for antihistamines consumed annually is about $ 5 billion a year. According to the data on domestic atopic dermatitis, allergic diseases have recently increased rapidly, and atopic dermatitis in children over 7 years old in Korea has increased significantly compared to 10 years ago.

Most of them heal naturally during the early years of childhood or childhood, but in recent years, they have been able to continue their social life. For atopic dermatitis, steroids, antihistamines, corticosteroids, and antibiotics are used in secondary infections, but these are mainly raw materials in the pharmaceutical field. Using only to approach the concept of relieving dryness of atopic skin rather than the treatment of diseases mainly.

Conventional products for the treatment of atopic dermatitis are in the form of ointments or creams, which are not only accompanied by pain when applied to the skin, but also due to the high flowability of the ointment applied to the topical area, which is caused by external flow and external contact. Ointment is often wiped out. That is, the leakage of this ointment not only reduces the therapeutic effect but also causes visual and tactile discomfort.

Accordingly, it is an object of the present invention to provide a hydrogel composition for treating atopy and a matrix patch comprising the same.

Hydrogel composition for treating atopic dermatitis according to the present invention for achieving the above object, the skin has a moisturizing function similar ceramide (Pseudoceramide), Cerix 5 (Cerix 5), cerazole (Cerasol), moistin (Moistin), epidermis A first raw material of at least one of extract, evening primrose seed oil, borage oil, jojoba oil, olive oil, Elhibin, and Stimu-tex AS; A second raw material of at least one of Scutellaria baicallensis Georgi extract, sewage extract, chamomile extract, and dismutin BT having anti-allergic efficacy; And at least one of Phytospingosine, Echochocho extract, Situary Mushroom Extract, Cordyceps Sinensis Extract, Lavender Oil, Tea Tree Oil, Apricot Seed Oil, Atofree, and Lipapide UG with antimicrobial efficacy. It includes a third raw material.

Preferably, the hydrogel composition is characterized in that it further comprises at least one natural polymer material of carrageenan and locust bean gum which is a natural polymer material.

In addition, the hydrogel composition is characterized in that it further comprises a synthetic polymer material of at least one of sodium polyacrylate, polyacrylic acid, sodium carboxymethyl cellulose, and carboxymethyl polymer which is a synthetic polymer material.

In addition, the hydrogel is characterized in that the water-soluble hydrogel.

Meanwhile, the matrix patch for treating atopy according to the present invention is characterized by using the hydrogel composition as a matrix.

When the matrix patch using the hydrogel composition according to the present invention is attached to the affected area with atopic dermatitis, it prevents the loss of moisture of the skin by strengthening the skin barrier function and strengthens the resistance and immunity to external stimulants to prevent secondary infection. At the same time it is possible to bring about the effect of preventing and mitigating atopic dermatitis.

Hereinafter, with reference to the drawings will be described the present invention in more detail. It should be noted that the same elements in the figures are represented by the same numerals wherever possible. In addition, detailed descriptions of well-known functions and configurations that may unnecessarily obscure the subject matter of the present invention will be omitted.

The hydrogel composition for treating atopy according to the present invention includes all or part of a raw material having a skin moisturizing function as a first raw material, a raw material having anti-allergic efficacy as a second raw material, and a raw material having antibacterial efficacy as a third raw material. have.

These first raw materials, the second raw materials, and the third raw materials are natural raw materials that are effective for atopy, and various raw materials may be exemplified as follows.

First, as a first raw material having a skin moisturizing function, pseudoceramide, Cerix 5, cerazole, moistin, lettuce extract, evening primrose oil, borage oil, jojoba Oils, olive oil, Elhibin, and alti-oil AS.

Pseudoceramide ( Pseudoceramide )

Important for the role of skin protection is spingolipids, including ceramides. Ceramides and sphingolipids, which are the most important components in the skin barrier, are responsible for inhibiting evaporation of moisture. . In addition, ceramides and sphingolipids control the growth and differentiation of the skin and inhibit inflammation and hyperplasia of the skin.

About 7% of the skin's slingolipids are present in the basal layer, which reaches more than 40% of the total lipids that make up the stratum corneum. Among them, ceramide, which is more important than any other component, is broken down in normal skin and converted into spingosine or phytospingosine, which acts as an antimicrobial barrier against the microorganisms on the skin surface.

In addition, phytospingosine, which forms the basic skeleton of ceramide, performs various functions such as anti-inflammatory and wound recovery, contributing to normalizing dysfunction of the skin.

- Cerix  5 ( Cerix  5)

Ceryx 5 (Doosan corporation) has excellent affinity through optimization of keratin lipids and has the effects of ceramide and phytosphingosine at the same time. In particular, Cerix 5 has a multi-layered layered structure similar to the stratum corneum and rapidly penetrates the skin, and is excellent for restoring damaged skin barrier and moisturizing effect, which is effective for improving dry and atopic skin and also for alleviating skin irritation.

-Cerazole ( Cerasol )

Important in the role of skin protection is the sphingolipids, including ceramides, ceramides and sphingolipids are the most important components in forming a skin barrier to inhibit the evaporation of moisture. In addition, ceramides and sphingolipids control the growth and differentiation of the skin and inhibit inflammation and hyperplasia of the skin.

-Moistin ( Moistin )

Moistin (Eurocostec Co., Ltd.) is a skin-friendly moisturizing ingredient containing dietary fiber components derived from Baeknyeoncho (Jeju palm cactus fruit), mucopolysaccharide component and amino acid component extracted from malt. In addition, moistine has the most moisturizing effect among the moisturizing agents, and it is also essential for atopy because of its excellent stimulating effect.

-Morus Extract

Phenylflavones contained in lettuce skin are known to inhibit potent tyrosinase activity, and water-soluble ingredients have anti-inflammatory and moisturizing effects.

-Evening Primrose Seed oil (skin Geological layer  supplement)

Evening primrose oil contains gamma-linolenic acid (GLA), dihomogamma-linolenic acid, and arachidonic acid to reduce these components. Evening primrose oil contains a natural form of gamma-linolenic acid that contains more than 7 to 8% of all fatty acids, which are ingested from the outside as unsaturated fatty acids that cannot be synthesized in the body. It must be done, but in nature it is contained only in the evening primrose and breast milk.

Because of these gamma-linolenic acids (omega-6 fatty acids), evening primrose oil has an excellent effect on preventing diseases and improving health, and in particular, removes inflammatory reactions and inflammation-causing substances in the body, and has excellent effects on atopic dermatitis and other skin diseases. have. In particular, a decrease in gamma-linolenic acid metabolites has been found in patients with atopic dermatitis.

- Borage oil

It contains 40% linoleic acid and 25% gamma-linolenic acid, and gamma-linolenic acid is known to be effective for healing dermatitis and inhibiting aging, and relieves symptoms of atopic dermatitis. In addition, it is rich in vitamins A, D, E and K, which has excellent antioxidant effects.

- Jojoba  oil

It promotes the spreading and lubricity of the skin, so it can be quickly absorbed through the pores and hair follicles, and contains a complex of minerals and vitamins, making the skin silky smooth. It is good for moisturizing and cleanliness, and it penetrates the skin quickly. Jojoba oil is very similar to the sebum molecular structure in humans, and its moisturizing properties help protect skin.

-Olive oil

Purely refined olive oil provides excellent moisturizing power It contains vitamin A and vitamin E for excellent antioxidant effects, harmful chemicals to human body, pure refined oil without coloring agents, soothes skin and maintains a healthy and healthy skin to form a skin barrier membrane do.

El Hibin Elhibin )

As skin connective tissue, it acts to inhibit the action of elastase, an enzyme that degrades elastin, a skin elasticity factor. Pentapharm LTD. Cancels the activity of elastase enzyme, which is greatly increased by physiological aging, other external environment such as ultraviolet rays or dermatitis, and stops aging process and prevents wrinkles by preventing the breakdown of elastin, a skin elastic fiber. effective. In addition, it is excellent in moisturizing, elasticity and irritation relief for atopic skin sensitive skin.

- Stimu - tex AS

Stimu-tex AS (Pentapharm LTD.) Contains a large amount of active ingredients, such as linoleic acid, which maintains skin improvement, forms and protects the skin's permeation layer, and provides grain wax and skin protection with excellent irritation and skin suppleness. Selects vegetable oil portion of argan oil, which contains high amounts of shea butter, vitamin E, linoleic acid, carotinoids, and unsaponifiable fatty acids As a raw material, it is effective for atopic skin and sensitive skin by protecting skin with the function of alleviating skin irritation, anti-inflammatory, antihistamine, skin moisturizing and skin membrane protection.

Next, examples of the second raw material having anti-allergic efficacy (antihistamine efficacy, itching relief, stimulation relief) include gold (Scutellaria baicallensis Georgi) extract, sewage extract, chamomile extract, and dismutin BT. Can be.

-Golden extract ( Huang 芩 ; Scutellaria baicallensis Georgi )

Gold belongs to Lamiaceae, and gold is dried root in herbal medicine. In spring or autumn, the roots are dug up, scrape off the bark and rotten genus, wash it in water, dry it in the sun and use it as a medicine. The root contains more than 35% of flavonoids, which are yellow, and the representative ones are Baikallein and Ugonin. Due to the abundant Baikal, Baikallein and ugonin components, it shows excellent antioxidant function and prevents photoaging in ultraviolet light. In addition, it has excellent skin sedation, anti-inflammatory and antibacterial effects. It is effective for skin whitening and prevents skin damage by inhibiting tyrosinase activity and blocking UV rays.

Gold extract shows over 90% SOD (super oxide dismutase) -like activity at 0.1% concentration, which removes free radicals that adversely affect atopic skin. The golden extract also acts as a natural preservative because it prevents the decay of the product, greatly reducing skin irritation and allergies that may be caused by synthetic preservatives.

- Shouao  extract

Inflammation, sputum and phlegm, treatment of all kinds of boils, hemorrhoids, chronic fatigue, gynecological treatment of women's postpartum disease, treatment of gynecology, qi and blood, strengthen musculature, faithful bone marrow, protect liver and kidney, Shows the effect of clearing blood. Tonic action, hematopoietic function strengthening, fatigue recovery promoting action, sedation and so on.

- Chamomile  extract

Triglyceride of oleic acid (triglyceride) forms a moisturizing film on the stratum corneum of the skin to smooth dry skin.

- Dismutin BT

Dismutin BT (Pentapharm LTD.) Is an antioxidant that has 1,000 times more antioxidant activity than vitamin E. SOD (superoxide dismutase) protects the skin with an enzyme that removes free radicals.

Finally, the third raw material having an antimicrobial effect is Phytospingosine, Echochocho extract, Sichuan mushroom extract, Cordyceps sinensis extract, Lavender oil, Tea tree oil, Apricot seed oil, Atofree, and Lipaside ( Lipacide) UG, for example.

-Phytosphingosine ( Phytospingosine )

Phytosphingosine (Doosan corporation), along with sphingosine and sphinganin, is a substance that forms the basic skeleton of sphingolipids. Phytosphingosine produced from the breakdown of ceramide is found to exist in the stratum corneum by about 1 ~ 2%, which has been shown to play the role of antimicrobial action against external microorganisms, alleviation of inflammation of skin and wound of skin. lost.

Eochocho extract

This plant is a perennial herb that grows in the shade of mountains and grows in southern Korea, Jeju Island, and Ulleungdo. It has a slightly spicy taste of leaves that resemble sweet potato leaves on red stems. It is called Eoseongcho because it smells like fishy fishy smell on stems and leaves. Also, it is called as a medicine, herbal medicine, juice, etc., and it is known as a plant that is widely used for anti-cancer activity due to its strong antibacterial and detoxification. In addition to itching, cell regeneration, antioxidant activity is excellent.

-Situation Mushroom Extract

Situation mushrooms contain nutrients such as potassium, calcium, magnesium, vitamins B2, B3, C, fiber and amino acids and contain a large amount of beta-glucan (β-glucan), which is excellent for enhancing immune function in the human body. .

Situation mushroom basidiomycete is a protein-bound polysaccharide, and also includes basic proteins, and protein polysaccharides do not have a toxic effect on normal cells. In addition, the situational mushroom extract inhibits the release of histamine, which mediates itching, and interferes with the binding of substance P (Substance P) -NK1 receptor, which is a major mediator of itching, which is effective in relieving itching as well as relieving atopic dermatitis. .

Cordyceps Sinensis Extract

Enhances immune donation and helps defend human and exogenous human body.

Lavender oil

It is effective for regenerating, disinfecting, disinfecting skin, and irritating hands and feet. It is effective for inflammation, erythema, burns and sunburn, and also has excellent anti-inflammatory and antibacterial effects. Lavender goes well with oils like rosemary, clary sage, juniper berry, lemon, orange and bergamot.

- Tea tree  oil

Used for insect bites, early cold symptoms, immune system enhancement, sterilization, fungi, fungus removal, astringents, oily skin or skin impurities. Effective in small amounts, it can also irritate sensitive skin. Use it later. In addition, it is good for removing oily skin and skin impurities, warts, foot treatment, hands and toenail fungus, and is used to obtain strong bactericidal effect on mucous membranes.

Apricot Seed Oil

Its main component, oleic acid and linoleic acid, are triglycerides and have a low proportion of saturated fatty acids, making them clear liquids even at low temperatures. It contains tocopherol, which removes free radicals that are harmful to the human body, making it suitable for aging skin and sensitive skin.

-Atopri ( Atofree )

Atopri (Eurocostec Co., Ltd.) is an extract of saponin, vitamin A and branching extract, which contains oleanolan oligosaccharide glycoside, morpholine 1C, 2-O-β-D-Glucopyranocylmomordin, and fermentation of perennial fruit and malt. Natural viscous polysaccharide, a product, is moistin (Eurocostec Co., Ltd.), which has excellent moisturizing power as a main ingredient, and phytocalm ((Note) ) Eurocostec) is a mixed extract.

-Lipacide UG

Glycine is the most common amino acid in proteins, an indispensable material in skin cell metabolism, and a major source of dermal structural proteins. Lipacide UG (Pentapharm LTD.) Can be used as a glycine mediator in the form of lipoamino acids, which closely resembles the natural structure of organics and facilitates skin penetration of glycine. Lipacide UG purifies the skin, weakens the skin and has excellent antibacterial and anti-inflammatory properties.

On the other hand, the hydrogel according to the present invention (Hydrogel) is a natural polymer such as carrageenan (carageenan, locust bean gum), or semi-synthetic polymer such as sodium carboxymethyl cellulose (Sodium Carboxymethyl Cellulose), or polyacrylic acid It is prepared by combining synthetic polymer materials such as sodium polyacrylate, polyacrylic acid, carboxyvinylpolymer, and the like by adding moisturizing glycerin, preservatives, crosslinking agents, and pH adjusting agents.

Carrageenan is a hydrothermal extract of seaweeds (Chondrus crispus, Gigartina manillosa, Gigarrtina stellata) belonging to the red algae. It forms the basic structure of galactan type which repeats β-D-galactose connected by β-1,3 bond and α-D-galctose connected by α-1,4 bond. The addition of potassium salts in aqueous solutions of carrageenan can form gels and increase their ability as thickeners. Carrageenan, which has protein reactivity, has a negative charge at pH above isoelectric point, and the protein has a positive charge. Therefore, carrageenan and protein undergoes ionic bonds, hydrogen bonds, and electrostatic bonds with each other to form a carrageenan-protein complex, which increases protein stability and, when present with other hydrophilic colloids, binds to molecules and ionic bonds. Synergistic.

Locust Bean Gum (LBG) is a polysaccharide obtained from the seeds of perennial legumes (Ceratonia siliqua, carob tree, ever green tree), grown in Spain, Italy, Morocco, Turkey and Portugal. Alternatively, the LBG powder may be dissolved in water to dissolve, and after filtration, the polysaccharide thereof may be obtained by precipitation of alcohols. White or slightly yellowish brown powder with a molecular weight of 310,000, granular, odorless or with a slight soybean odor.

It disperses in cold water but does not dissolve in part. It melts completely at 80 ° C and becomes a viscous liquid. It has little effect at pH 3.5∼9.0 and the viscosity is lower at other pHs. The lean salts, salts and solutions of magnesium and calcium chloride do not affect the viscosity, but are salted by acids, in particular inorganic acids and oxidizing agents, and the viscosity decreases.

Mixing gelatin, glucose, sucrose, and glycerin before salting will prevent some salting out. Surface tension is reduced by heat, pressure, friction, for example, by stirring. Viscosities are partially expressed in cold water and are fully viscous when cooled to room temperature after warming above 90 degrees.

Sodium Carboxymethyl Cellulose is one of the water-soluble cellulose derivatives and is the sodium salt of carboxymethyl ether of cellulose. The aqueous solution is highly viscous and has properties such as film forming ability, protective colloid, adhesiveness and emulsion stability. Carboxymethyl cellulose sodium generally has a degree of substitution of about 0.7 in commercial products and high hygroscopicity.

Unlike methyl and ethyl cellulose, it is more soluble in cold water than hot water, and the viscosity of aqueous solution is different depending on the pH of the solution. Solute is precipitated below pH 2, and the viscosity is significantly lower than pH 7 above pH 10. There are also many water soluble materials and usability.

Sodium polyacrylate (Sodium polyacrylate) is a sodium salt of the acrylic acid polymer having a very high viscosity compared to other synthetic pastes 10 times the viscosity. Monovalent salts do not produce precipitates but form insoluble metal salts with polyvalent metal ions. In addition, hygroscopicity is strong, and when water is added, it becomes a swelling and viscous uniform solution.

The carboxyvinyl polymer, which is a water-soluble vinyl polymer, increases in viscosity by neutralization and has a thickening effect in comparison with rubbery to form gels. There is no change in viscosity with temperature, and the presence of excess salts decreases the viscosity and shows a significant trend in polyvalent salts. Used as a thickener, it has a viscosity of 1,500-40,000 cP (0.2% aqueous solution) at pH 7.0-7.5.

Glycerin is a colorless, transparent, sweet, sticky liquid that is highly hygroscopic. As esters with fatty acids, they are widely distributed in animal and vegetable systems in the form of fats and oils and lipids. It is used as an enema, humectant, and viscous agent, and is widely used in food and cosmetics as a drying inhibitor, as a flavoring agent, as a paint, as a printing ink, as a raw material for transparent soap, and as an analytical reagent.

Preservatives are added to prevent the decay of organic substances by the action of microorganisms and for the purpose of preservation. In general, preservatives are added to prevent the deterioration of food, cosmetics and pharmaceuticals and to maintain their purity while using or preserving them. Therefore, it is essential that there is no harm to the human body, and the addition should not impair the quality.

In medicine, sodium salts of benzoic acid are added to eye drops, homemade drugs, and injections. Food is also called food preservative, and its use is regulated under the Pharmaceutical Affairs Law and Food Hygiene Law as with medicines.

In carrying out the present invention, a hydrogel may be prepared using a natural polymer, and in the preparation of a hydrogel including a carrageenan and a locust bean gum, which are natural polymers, and a moisturizer and a preservative, a specific amount of glycerin Carrageenan and locust bean gum, which are natural polymers, are dispersed and stirred while slowly added to 70 ° C purified water. After that, the mixture is stirred until a uniform solution is used, and then a coating gel is used to prepare a hydrogel having a constant thickness. (Hydrogel I)

On the other hand, it is prepared by the same method as hydrogel I, it is also possible to prepare a hydrogel by changing the properties of the hydrogel by controlling the content of carrageenan and locust bean gum (hydrogel II).

In addition, the hydrogel prepared by the same method as hydrogel I and by adjusting the carrageenan and locust bean gum content and the type of carrageenan will be able to prepare a hydrogel (hydrogel III).

In addition, in the practice of the present invention, a hydrogel may be prepared using a synthetic polymer, specifically, a polyadjusting agent, such as sodium polyacrylate, polyacrylic acid, sodium carboxymethyl cellulose and carboxyl methyl polymer, may be prepared using a pH adjuster, Preservatives, crosslinkers, moisturizers, etc. may be mixed to produce a uniform hydrogel (hydrogel IV).

In carrying out the present invention, the hydrogel composition comprising the above-mentioned hydrogel I, hydrogel II, hydrogel III, hydrogel IV natural polymer or synthetic polymer material contains a natural raw material effective for atopic dermatitis in Table 1 As such, it is possible to prepare a hydrogel composition according to various embodiments.

Sample 1  Cerix 5 (ceramide Ⅲ, phytosphingosine, etc.) Hydrogel Ⅰ Sample 2  Pseudoceramide, phytospingosine Hydrogel Ⅰ Sample 3  Pseudoceramide, Echo Extract Hydrogel Ⅰ Sample 4  Pseudoceramide, Atofree (branch, zinnia, malt, elm extract) Hydrogel Ⅰ Sample 5  Alligator, Rice Embryo, Eoseongcho, Situation Mushroom Extract Hydrogel Ⅰ Sample 6  Cerix 5 (ceramide Ⅲ, phytosphingosine, etc.) Hydrogel Ⅰ Sample 7  Lipacide UG, Elhibin, Dismutin BT, Stimu-tex AS, Cerasol Hydrogel Ⅰ Sample 8  Cerix 5 (ceramide Ⅲ, phytosphingosine, etc.) Hydrogel II Sample 9  Lipacide UG, Elhibin, Dismutin BT, Stimu-tex AS, Cerasol Hydrogel II Sample 10  Cerix 5 (ceramide Ⅲ, phytosphingosine, etc.) Hydrogel III Sample 11  Lipacide UG, Elhibin, Dismutin BT, Stimu-tex AS, Cerasol Hydrogel III Sample 12  Cerix 5 (ceramide Ⅲ, phytosphingosine, etc.) Hydrogel IV Sample 13  Lipacide UG, Elhibin, Dismutin BT, Stimu-tex AS, Cerasol Hydrogel IV Sample 14  Pseudoceramide, moistin extract, golden, fish extract Hydrogel IV Sample 15  Pseudoceramide, Sickle Mushroom, Geumsong, Morus extract Hydrogel IV Sample 16  Sewage Extract, Borage Oil, Lavender Oil Hydrogel IV Sample 17  Chamomile Extract, Jojoba Oil, Tea Tree Oil Hydrogel IV Sample 18  Cordyceps sinensis extract, evening primrose oil, apricot seed oil Hydrogel IV

In addition, in the practice of the present invention it is possible to prepare a matrix patch for atopic treatment by using the hydrogel composition prepared according to the embodiment in Table 1 as a matrix. In addition, the hydrogel composition according to the present invention may be used as a matrix of a hydrogel patch for wound treatment, a matrix of a transdermal drug delivery patch, and also used as a matrix in other skincare patches cosmetics. Could be.

In addition, in the practice of the present invention, if the water-soluble hydrogel of the new formulation is used, it has a moisturizing effect, a cooling effect of lowering heat, and dissolution occurs during skin adhesion, so that an active ingredient is gradually released to promote healing of the wound, and damaged. It helps regenerate the skin and makes the skin regenerate as quickly as possible during the healing process so that no scars are formed.

In addition, in the case of using the water-soluble hydrogel in the practice of the present invention, the ability to control the wound secretion, ease of attachment and removal of the dressing to the wound, air and water permeability of the wound, heat insulation of the wound to the outside, It can effectively heal atopy by securing resistance to invasion of bacteria, non-toxicity to human body and excellent mechanical properties.

While the above has been shown and described with respect to preferred embodiments and applications of the present invention, the present invention is not limited to the specific embodiments and applications described above, the invention without departing from the gist of the invention claimed in the claims Various modifications can be made by those skilled in the art, and these modifications should not be individually understood from the technical spirit or the prospect of the present invention.

Claims (5)

Pseudoceramide, Cerix 5, Cersol, Moistin, Morus extract, Evening Primrose Oil, Borage Oil, Jojoba Oil, Olive Oil, Elhibin And a first raw material of at least one of Stimu-tex AS; A second raw material of at least one of Scutellaria baicallensis Georgi extract, sewage extract, chamomile extract, and dismutin BT having anti-allergic efficacy; And At least one agent of Phytospingosine, Echochocho extract, Sichuan mushroom extract, Cordyceps sinensis extract, Lavender oil, Tea tree oil, Apricot seed oil, Atofree, and Lipapide UG with antimicrobial efficacy 3 raw material Hydrogel composition for atopic treatment comprising a. The method of claim 1, The hydrogel composition is a hydrogel composition for treating atopy further comprising at least one natural polymer material of carrageenan and locust bean gum, which is a natural polymer material. The method of claim 1, The hydrogel composition is a hydrogel composition for treating atopic dermatitis further comprising at least one synthetic polymer material of sodium polyacrylate, polyacrylic acid, sodium carboxymethyl cellulose, and carboxyl methyl polymer which is a synthetic polymer material. The method of claim 1, Wherein the hydrogel is a water-soluble hydrogel atopic hydrogel composition. A matrix patch for atopic treatment using the hydrogel composition of claim 1 as a matrix.