CN108159247B

CN108159247B - Protective composition containing peach blossom extract and application thereof

Info

Publication number: CN108159247B
Application number: CN201810102348.XA
Authority: CN
Inventors: 练旗旗; 刘瑞学; 冷群英
Original assignee: Guangdong Bawei Biotechnology Co ltd
Current assignee: Guangdong Bawei Biotechnology Co ltd
Priority date: 2018-02-01
Filing date: 2018-02-01
Publication date: 2021-04-20
Anticipated expiration: 2038-02-01
Also published as: CN108159247A

Abstract

The invention discloses a protective composition containing a peach blossom extract and application thereof, and aims to provide a protective composition containing a peach blossom extract, which can moisturize and moisturize, resist bacteria and diminish inflammation and form a skin protection barrier, wherein the technical scheme comprises the following components in parts by weight: 4-6 parts of monarch drug, 1.6-2.4 parts of ministerial drug composition, 1.6-2.4 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition; the monarch drug is peach blossom extract; the ministerial drug composition comprises wintergreen extract and asparagus extract; the adjuvant composition comprises a parasitic loranthus extract and a cynanchum paniculatum extract; the said medicinal composition comprises semen glycines powder, protease dextran and Mel extract; belongs to the technical field of skin care products.

Description

Protective composition containing peach blossom extract and application thereof

Technical Field

The invention relates to a protective composition, in particular to a protective composition containing a peach blossom extract, and belongs to the technical field of skin care products.

Background

With the rapid development of production and economy, environmental pollution is increasingly serious, and sand storm, heavy metals, industrial waste gas, automobile exhaust, ultraviolet rays, haze, PM2.5 and the like are common pollution sources at present. The skin is exposed in the air for a long time and is influenced by the pollution sources, so a series of skin problems are easily caused, such as sand storm and waste gas pollution can increase the active oxygen group of the skin, and the aging process of the skin is accelerated; PM2.5 these fine dusts are easy to block pores, and toxic and harmful substances such as heavy metals, fungi, bacteria and the like are easy to attach to the dusts, so that the acne and skin allergy symptoms are caused; haze can cause skin to generate excessive extremely unstable free radicals, which cause damage to DNA and protein and lipid peroxidation, resulting in problems of darkness, pigmentation, laxity, dryness, wrinkles and the like.

Under such circumstances, anti-pollution cosmetics with protective efficacy are produced and are greatly favored by consumers, and the proportion of the anti-pollution cosmetics in daily chemical sales is also continuously increased, so that the anti-pollution cosmetics become a main direction of research in daily chemical industry. Most of the existing protective cosmetics on the market only add cleaning and film forming components or ultraviolet ray attractants and the like, can only achieve the effects of simply cleaning the face, moisturizing or resisting ultraviolet rays, cannot really and effectively resist various pollution sources comprehensively, and has insignificant anti-pollution effect.

Disclosure of Invention

In view of the above problems, a first object of the present invention is to provide a protective composition containing a peach blossom extract, which can enhance the natural barrier function and anti-irritation capability of the skin, has various effects of removing free radicals, effectively inhibiting bacteria, relieving and resisting allergy, caring and repairing the skin, and can effectively resist the problems of skin allergy, aging, etc. caused by external pollutants.

The second purpose of the invention is to provide the application of the protective composition containing the peach blossom extract.

Therefore, the first technical scheme provided by the invention is as follows:

a protective composition containing a peach blossom extract comprises the following components in parts by weight: 4-6 parts of monarch drug, 1.6-2.4 parts of ministerial drug composition, 1.6-2.4 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition comprises wintergreen extract and asparagus extract;

the adjuvant composition comprises a parasitic loranthus extract and a cynanchum paniculatum extract;

the said composition comprises semen glycines seed powder, protease dextran and Mel extract.

Further, the protective composition containing the peach blossom extract is characterized by also comprising a rehmannia root extract and a peach kernel extract.

Further, the protective composition containing the peach blossom extract is characterized in that the adjuvant drug composition also comprises an almond extract.

Further, the protective composition containing the peach blossom extract is characterized by comprising the wild soybean seed powder, the protease glucan and the honey extract according to a mass ratio of 4-5: 1-2: 2-3.

Furthermore, the protective composition containing the peach blossom extract comprises the wintergreen extract, the asparagus cochinchinensis extract, the rehmannia root extract and the walnut kernel extract according to a mass ratio of 5-6: 3-4: 5-6.

Furthermore, the adjuvant drug composition containing the peach blossom extract is composed of the parasitic loranthus extract, the cynanchum paniculatum extract and the almond extract according to the mass ratio of 3-4: 5-6: 9-10.

The second technical scheme provided by the invention is that the protective composition containing the peach blossom extract is applied as a skin care product additive, and the addition amount of the protective composition is 0.1-10% of the total mass of the skin care product in terms of mass fraction, and preferably 2-8% of the total mass of the skin care product.

Compared with the prior art, the utility modelThe invention has the advantages as follows

1. The technical scheme provided by the invention takes the concept of 'monarch, minister, assistant and guide' of traditional Chinese medicine as guidance to carry out prescription, andthe peach blossom extract is a monarch drug, the wintergreen extract, the asparagus extract, the rehmannia root extract and the walnut kernel extract are ministerial drugs, the parasitic loranthus extract, the paniculate swallowwort root extract and the almond extract are adjuvant drugs, and the wild soybean seed powder, the protease glucan and the honey extract are messenger drugs, so that the effects of strengthening the body and consolidating the constitution, nourishing and conditioning are achieved, and the skin immunity is enhanced as an anti-pollution basis; the anti-pollution targets are anti-inflammation, sterilization, relieving, anti-allergy, skin nursing and repairing.

2. The peach blossom extract provided by the invention contains nutrient substances such as kaempferol, coumarins, trifolioside, beta carotene, vitamin A, B, C and the like, and the substances can expand blood vessels, dredge veins, moisten skin, improve blood circulation, promote skin nutrition and oxygen supply, accelerate metabolism, enhance the disease resistance of skin and have good effects of resisting inflammation, bacteria, whitening and resisting oxidation.

3. In the technical scheme provided by the invention, the wintergreen extract, the cochinchnese asparagus root extract, the rehmannia root extract and the walnut kernel extract are used as ministerial drugs together, the wintergreen is recorded in the traditional Chinese pharmacology to be capable of tonifying deficiency, dispelling wind and removing dampness, promoting blood circulation to restore menstrual flow and stopping bleeding, the contained wintergreen has an inhibiting effect on staphylococcus aureus, typhoid bacillus, pseudomonas aeruginosa, escherichia coli and the like, and medical data shows that the wintergreen also has an immune promoting effect; the whole plant of radix asparagi contains a plurality of nutrient components such as asparagine, beta-sitosterol, solid saponin, mucus, furfural derivatives, amino acid, vitamin and the like, can supplement nutrition for skin, and simultaneously has the functions of removing free radicals, resisting lipid peroxidation and resisting bacteria; the rehmannia root extract has a promoting effect on the growth of fibrin, shows that the rehmannia root extract has the effect of enhancing the metabolism of skin, also has the moisture absorption capacity in a low-humidity environment, and has the effects of controlling oil, resisting seborrhea, softening the skin and moistening the skin; the walnut kernel is the pulp in walnut kernel, contains various amino acids and fatty acids, and can sterilize, moisturize, nourish, moisten, astringe skin and relieve allergy. The four components are used as ministerial drugs to assist monarch drugs in providing rich nutrient substances for skin, conditioning and strengthening skin, and simultaneously have the effects of oxidation resistance, inflammation resistance and bacteria resistance.

4. According to the technical scheme provided by the invention, the parasitic loranthus extract, the cynanchum paniculatum extract and the almond extract are used as adjuvant drugs together, the almond has rich nutrient substances, the parasitic loranthus is capable of relieving stress, calming and resisting viruses, the cynanchum paniculatum is capable of preventing allergy, resisting inflammation and purifying the skin, and the three components have synergistic effects, so that dermatitis can be prevented and resisted, skin swelling and pruritus caused by allergy can be relieved, and the barrier function of the skin can be repaired.

5. According to the technical scheme provided by the invention, the wild soybean seed powder, the protease glucan and the honey extract are used as messenger medicines together, wild soybeans contain higher nutrient components such as lecithin and the like than common soybeans, the wild soybean seed powder is decomposed by protease, and the honey extract is matched to improve the permeability of skin, promote the absorption of the skin on monarch medicines and nutrient components in the messenger medicines, solve the problem of transdermal absorption of oral traditional Chinese medicines acting on the skin, and simultaneously form a layer of nutrient film on the surface of the skin to achieve the purpose of nourishing the deep skin.

Detailed Description

The claims of the present invention are described in further detail below with reference to specific embodiments.

It should be noted that the raw materials used in the technical scheme provided by the invention are prepared by conventional means or purchased from commercial sources except for special instructions.

The peach flower extract is purchased from

Honey extract purchased from Huzhou Jiamei Biochemical products Co., Ltd

Extract of Loranthus mulberry mistletoe (Taxilluschinensis) was purchased from Shanxi Haoyang Biotech limited

The extract of Cynanchum paniculatum (Cynanchum paniculatum) is obtained from bioscience and technology, Inc. of Xianjin

Almond extract was purchased from Guangzhou Youran Biotech Co., Ltd

The rehmannia root extract is purchased from Beijing institute of anti-confirmatory biochemical technology

The extract of semen Persicae is purchased from Shaanxi Haoyang Biotech limited

Pyrola extract purchased from Saanera biotechnology limited

Asparagus cochinchinensis extract was purchased from Siemens Mingze Biotech Ltd

Example 1

The invention provides a protective composition containing a peach blossom extract, which comprises the following components in parts by weight: 4g of monarch drug, 2.4g of ministerial drug composition, 1.6g of adjuvant drug composition and 0.8g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition consists of a wintergreen extract and an asparagus cochinchinensis extract according to the mass ratio of 5: 3;

the adjuvant drug composition consists of a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 3: 5;

the messenger medicinal composition comprises wild soybean seed powder, protease dextran and honey extract at a mass ratio of 4: 1: 2.

Example 2

The invention provides a protective composition containing a peach blossom extract, which comprises the following components in parts by weight: 6g of monarch drug, 1.6g of ministerial drug composition, 2.4g of adjuvant drug composition and 0.8g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition consists of wintergreen extract and cochinchnese asparagus root extract according to the mass ratio of 6: 4;

the adjuvant drug composition consists of a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 4: 6;

the messenger medicinal composition comprises wild soybean seed powder, protease dextran and honey extract at a mass ratio of 5: 2: 3.

Example 3

The invention provides a protective composition containing a peach blossom extract, which comprises the following components in parts by weight: 5.5g of monarch drug, 2.2g of ministerial drug composition, 2.2g of adjuvant drug composition and 1.1g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition consists of wintergreen extract, cochinchnese asparagus root extract, rehmannia root extract and walnut kernel extract according to the mass ratio of 5: 4: 3: 6;

the adjuvant composition consists of a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 3: 5;

the messenger medicinal composition comprises wild soybean seed powder, protease dextran and honey extract at a mass ratio of 4: 2: 3.

Example 4

The invention provides a protective composition containing a peach blossom extract, which comprises the following components in parts by weight: 4.8g of monarch drug, 1.8g of ministerial drug composition, 1.8g of adjuvant drug composition and 0.9g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition is composed of wintergreen extract and cochinchnese asparagus root extract according to the mass ratio of 5: 4.

The adjuvant composition comprises herba Taxilli extract, radix Cynanchi Paniculati extract and semen Armeniacae amarum extract at a mass ratio of 4: 6: 9.

The messenger medicinal composition comprises wild soybean seed powder, protease dextran and honey extract at a mass ratio of 5: 1: 2.

Example 5

The invention provides a protective composition containing a peach blossom extract, which comprises the following components in parts by weight: 5g of monarch drug, 2g of ministerial drug composition, 2g of adjuvant drug composition and 1g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition consists of wintergreen extract, cochinchnese asparagus root extract, rehmannia root extract and walnut kernel extract according to the mass ratio of 5: 3: 4: 6;

the adjuvant composition consists of a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 4: 5: 9;

the messenger medicinal composition comprises wild soybean seed powder, protease dextran and honey extract at a mass ratio of 4: 1: 3.

The preparation method of the composition comprises the following steps: the ministerial drug composition, the adjuvant drug composition and the messenger drug composition are mixed uniformly in advance according to the specified mass ratio, and then the monarch drug, the ministerial drug composition, the adjuvant drug composition and the messenger drug composition in parts by weight are weighed, added with a proper amount of deionized water and stirred uniformly to obtain the composition.

When the protective composition containing peach blossom extract in any one of examples 1 to 5 is used as a skin care product additive, the addition amount of the protective composition is 0.1-10%, preferably 2-8% of the total mass of the skin care product. The composition of the invention is best used when being prepared in a specific use mode, namely the composition is added into a corresponding skin care product matrix as a skin care product additive immediately after being prepared.

To better illustrate the effects of the present invention, comparative examples of experimental protocols of the present invention during development are given below.

Comparative example 1

The wintergreen extracts in the monarch drug and ministerial drug composition in the embodiment 5 are exchanged, and other components and contents are unchanged, namely:

a protective composition comprising the following components in parts by weight: 5g of monarch drug, 2g of ministerial drug composition, 2g of adjuvant drug composition and 1g of messenger drug composition;

the monarch drug is wintergreen extract;

the ministerial drug composition consists of peach flower extract, cochinchnese asparagus root extract, rehmannia root extract and walnut kernel extract according to the mass ratio of 5: 3: 4: 6;

Comparative example 2

The radix asparagi extract in the monarch drug and ministerial drug composition in the embodiment 5 is exchanged, and other components and contents are unchanged, namely:

the monarch drug is an asparagus extract;

the ministerial drug composition consists of wintergreen extract, peach blossom extract, rehmannia root extract and walnut kernel extract according to the mass ratio of 5: 3: 4: 6;

Comparative example 3

The wintergreen extract of the ministerial drug composition in the embodiment 5 is replaced by the asparagus cochinchinensis extract, and other components and contents are unchanged, namely:

a protective composition containing peach blossom extract comprises the following components in parts by weight: 5g of monarch drug, 2g of ministerial drug composition, 2g of adjuvant drug composition and 1g of messenger drug composition;

the monarch drug is peach blossom extract;

the ministerial drug composition consists of an asparagus cochinchinensis extract, a rehmannia glutinosa root extract and a walnut kernel extract according to a mass ratio of 8: 4: 6;

Comparative example 4

Replacing the parasitic loranthus extract in the adjuvant composition in the embodiment 5 with the cynanchum paniculatum extract, wherein the other contents are unchanged, namely:

the monarch drug is peach blossom extract;

the adjuvant drug composition consists of a paniculate swallowwort root extract and an almond extract according to a mass ratio of 9: 9;

Comparative example 5

The drug composition of example 5 is prepared by removing the protease dextran and keeping the contents of the other substances unchanged

the monarch drug is peach blossom extract;

the messenger medicine composition is composed of wild soybean seed powder and honey extract according to a mass ratio of 4: 3.

Experimental data for the peach blossom extract containing protective composition provided herein and comparative experiments therewith are given below.

First, efficacy test

Normal skin has a strong barrier function and can prevent external harmful substances from entering the skin. When barrier function is compromised, pathways are formed between keratinocytes from which water is lost. Thus, the transdermal loss of water increases when the skin barrier efficacy is diminished and decreases vice versa. The better the skin protection layer, the higher the moisture content and the lower the value of TEWL for skin moisture loss. The test evaluates the strength of the skin barrier function by the trans-dermal water loss (TEWL) and thus the anti-pollution efficacy of the compositions of the present invention.

The test samples were prepared by adding the compositions prepared in examples 1-5 and comparative examples 1-5 to a cream base at 5% each; cream base served as blank control.

The test population is selected from 110 healthy volunteers with dry skin and wrinkles such as dry lines, fine lines, expression lines and the like, the age is 30-45 years, the average age is 38 years, no allergy is caused to cosmetics, no acute inflammation is caused to the face, no hormone drugs or immunosuppressants are used, no other clinical tests are participated, and no external preparation is applied. The test samples were randomly divided into 11 groups of 10 persons each, and used in turn.

Test method three days before the test, the face without any cosmetic product, the TEWL value of the face before the product was used on day 1 was determined using the TEWL probe from CKMPA580 (5 tests, mean values read on computer). Cleaning face of each group of subjects with warm water every day, respectively applying equal amount of cream on facial skin, once in the morning and evening, continuously using for 28 days, stopping using the product in 29 and 30 days, measuring TEWL value with TEWL probe of CKMPA580 on 31 days, and calculating TWEL difference before and after use; the water content in the stratum corneum of the facial skin was measured using a skin moisture meter CorneometerCM825, and the hydration rate (%) was calculated; measuring the oil content of the skin of the forehead of the face by using a SebumetersM815 probe of an oil content tester; the skin elasticity of the face was measured using the skin elasticity tester MPA580 (the negative pressure was constant at 450MPA during the test), and the result was expressed as the ratio of the rebound amount Ur (i.e., the recovery value of the skin after 0.1 second of negative pressure removal) to the maximum tensile amount Uf of the skin, and the closer the value to 1, the better the skin elasticity. The results are shown in tables 1 and 2.

Table 1 results of barrier function test

Table 2 evaluation of skin improving efficacy of each test sample

Test sample	Skin hydration (%)	Skin elasticity (Ur/Uf)
			Example 1 cream	42.27±1.03	0.58±0.03
Example 2 cream	42.33±2.15	0.60±0.06
			Example 3 cream	49.56±1.67	0.69±0.05
Example 4 cream	47.99±1.65	0.67±0.03
			Example 5 cream	58.76±2.13	0.77±0.08
Comparative example 1 cream	22.67±1.45	0.35±0.03
			Comparative example 2 cream	23.62±1.03	0.33±0.04
Comparative example 3 cream	28.87±1.55	0.44±0.02
			Comparative example 4 cream	31.48±1.56	0.45±0.02
Comparative example 5 cream	35.62±1.60	0.50±0.04
			Cream base	8.35±0.90	0.10±0.01

The above test data show that the TEWL value of the skin water loss after the cream added with the composition of the embodiment of the invention is obviously lower than the TEWL value before the use, and the difference value of TWEL before and after the use is obviously higher than that of the cream substrate, which shows that the composition of the invention has the function of enhancing the skin barrier function; and the skin hydration value and the skin elasticity value are obviously higher than those of the cream matrix, which shows that the cream prepared by the composition in the embodiment has good moisturizing effect, can increase the skin elasticity, and achieves the effects of moisturizing and delaying senility.

After the cream added with the composition of the invention in the example 5 is used, the difference of TEWL, the skin hydration rate and the skin elasticity value are obviously higher than those of the cream added with the compositions of the comparative examples 1-2, which indicates that the peach blossom extract plays a main role in the composition of the invention and is an irreplaceable or lacked medicament in the formula; moreover, the difference of TEWL, the skin hydration rate and the skin elasticity value in example 5 are higher than those of the cream added with the compositions of comparative examples 3 to 4, which shows that the efficacy of the wintergreen extract, the asparagus root extract, the rehmannia root extract and the walnut kernel extract in the ministerial drug composition of the invention is obviously better than that of the asparagus root extract, the rehmannia root extract and the walnut kernel extract with the same total mass, and the rigor and scientificity of the formula of the invention is demonstrated; similarly, in order to prove the scientificity and rigor of the formulation of the present application, the applicant further replaces the extract of loranthus parasiticus in the adjuvant composition with the extract of cynanchum paniculatum of the same quality in the research process, namely, comparative example 4, and as a result, the difference of TEWL, the skin hydration rate and the skin elasticity value of the composition in comparative example 4 are also reduced after the composition is added into cream, which is specifically shown in table 1 and table 2.

In order to prove the role of the protease glucan in the technical scheme provided by the application, the applicant removes the protease glucan in the components in the research process, namely, the comparative example 5, and as a result, the difference of TEWL, the skin hydration rate and the skin elasticity value of the composition in the comparative example 5 are also reduced after the composition is added into cream, and particularly, the difference, the skin hydration rate and the skin elasticity value are shown in tables 1 and 2, and the applicant believes that the protease glucan can be matched with wild soybean seed powder and honey extract to improve the permeability of the skin, promote the absorption of nutrient components, and simultaneously form a layer of nutrient film on the surface of the skin to help to enhance the barrier function of the skin.

Second, inhibition of Propionibacterium acnes

Preparation of a sample: the compositions prepared in examples 1 to 5 were mixed uniformly, and then an equal amount of the mixture was used to prepare an aqueous sample solution, which was subjected to the following experiment.

The experimental method comprises the following steps: 1mL of each sample aqueous solution was added to a sterile glass test tube, and 8mL of the previously prepared modified GAM broth was poured. Taking out the purified CO and keeping the temperature of the CO constant at 35 DEG C₂Culturing clinical propionibacterium acnes for 48h in an incubator, respectively injecting 1mL of bacterial suspension into a broth culture tube filled with sample aqueous solution, and taking a glass tube without bacterial suspension as a negative control. Placing at 35 deg.C constant temperature CO as soon as possible after inoculation₂The incubator is used for 48 hours. After culturing, the liquid in the broth culture medium is extracted for a verification experiment, and the survival condition of the propionibacterium acnes is observed.

The experiment results show that the propionibacterium acnes cannot grow in the culture medium added with the composition of the invention in the examples 1-5, and the composition has obvious inhibition effect on the propionibacterium acnes.

Third, testing the tolerance to stimuli

The skin is stimulated by exogenous pollutants, so that red swelling, pruritus, erythema, wheeze and the like are often caused, the autoimmune function of the skin can be reduced over time to form sensitive skin, the health of the skin is seriously damaged, so that the damaged skin is repaired and the immunity of the skin is enhanced, which is the most fundamental mode for resisting the exogenous pollutants, and the anti-pollution effect of the test composition is evaluated through the skin stimulation effect.

Experimental method: -stimulating the left and right forearm flexor skin with 3% SLS solution and 5% fruit acid as stimuli until the redness is developed, applying a cream containing 8% of the composition of the invention according to example 1 to the left forearm area, applying a cream containing 8% of the composition of the invention according to example 5 to the right forearm area, and observing the degree of regression of the redness of the skin after 2 days.

Test results compared with 3% SLS stimulation of the left forearm area 1, marked redness and swelling of the skin, 8% of the skin after application

After 2 days of cream with the composition of example 1, the redness in left forearm area 1 had clearly subsided; after 5% of the fruit acid had irritated the right forearm area 2, the skin was visibly red and swollen in the right forearm area 2 was also visibly resolved after 2 days of application of a cream containing 8% of the composition of example 5 of the invention. The composition of the invention has obvious anti-irritation and anti-inflammation effects.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims

1. The protective composition containing the peach blossom extract is characterized by comprising the following components in parts by weight: 4-6 parts of monarch drug, 1.6-2.4 parts of ministerial drug composition, 1.6-2.4 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition;

the monarch drug is peach blossom extract;

the messenger medicinal composition comprises wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 4-5: 1-2: 2-3;

the ministerial drug composition comprises wintergreen extract, cochinchnese asparagus root extract, rehmannia root extract and walnut kernel extract according to the mass ratio of 5-6: 3-4: 5-6;

the adjuvant composition comprises herba Taxilli extract, radix Cynanchi Paniculati extract and semen Armeniacae amarum extract at a mass ratio of 3-4: 5-6: 9-10.

2. Use of a peach blossom extract-containing protective composition according to claim 1 as a skin care product additive.