CN106361599A - Multi-vegetable-oil-containing infantile eczema care cream - Google Patents

Abstract

The invention discloses a multi-vegetable-oil-containing infantile eczema care cream. The infantile eczema care cream is proportionally prepared from the following raw materials by a conventional cream preparation method: 10-30% of shea butter, 1-5% of camellia seed oil, 5-10% of Moringa oleifera seed oil, 1-5% of lanolin, 1-5% of Calm Yang (WAX), 0.5-1.0% of dendrobe/Tremella fuciformis extract and 1-5% of Calm Yang. The infantile eczema care cream can improve the skin, is nonirritating and safe for the skin, is mild, moisturizing and not oily, has favorable spreadability, has favorable itching relieving effects after use, and has favorable relieving effects on multiple skins.

Description

A kind of infant eczema maintenance cream containing various plants oil

Technical field

The present invention relates to a kind of eczema maintenance cream, specifically a kind of infant eczema maintenance cream containing various plants oil.

Background technology

Skin is the maximum organ of baby's body, and thin tender skin could gradually will be reached maturity when 3 years old about.Mother In addition to feeding baby, the problem of most critical is just to maintain the sanitation and hygiene of baby's skin and resists various dermatosis.Little The skin of baby is very tender and lovely, and it is uncomfortable or even ill that very slight stimulation just can make the skin of baby produce.And ask in many In topic skin, modal expression is infantile eczema, and eczema is a kind of very universal anaphylaxis dermatosis, can be sent out in each year Age section, sends out and is commonly called as infantile eczema in infancy stage.

Infant skin develop not bery sound, the horny layer of outermost layer epidermis is very thin, capillary network enrich, endothelium aqueous and Oxide is abundanter, so being susceptible to anaphylaxiss to cause eczema, the general appearance of eczema be born again after this section of January to 2 years old Time, big multipotency is alleviated automatically within two years old about, and with baby's most serious of 2-3 month.Often betide cheeks, scalp, forehead, eyebrow Between, after gill under cervical region, jaw, also extend to other positions, be usually expressed as diaper rash, infantile eczema, saliva rash, intertrigo and fat Excessive property dermatitis etc., in order to be able to effective various skin disorders preventing and treating baby, external Donisolone is still to be controlled Treat the key agents of eczema, but as immunizing agent, glucocorticoid should use with caution or without.

At present specific Therapeutic Method be there is no for eczema, be in most cases only capable of alleviating prurituss, reduce and stimulate, clinical General based on antfhistamine medicine, although such medicine can the effective control state of an illness, side effect larger it is possible to fragile to baby Skin cause certain damage, life-time service is also easy to cause dependence syndrome to a certain extent, and therefore precious mothers need one kind Skin sense can be improved, skin is not almost stimulated with gentle and safe baby's eczema maintenance product simultaneously.

Content of the invention

It is an object of the invention to provide a kind of infant eczema maintenance cream containing various plants oil.

Technical scheme is as follows:

A kind of infant eczema maintenance cream containing various plants oil, described infant eczema maintenance cream is to be joined in proportion by following The method of the raw material conventional preparation cream put is prepared from:

Vegetable oil lipoprotein shea butter 10%-30%, Camellia oil 1%-5%, seed oil of Moringa oleigera 5%-10%

Animal raw fat lanoline 1%-5%

Plant mixture lipophilic component calm yang(wax) 1%-5%

Plant additive Lin Lan profit dew 0.5%-1.0%

Plant mixture water-soluble composition calm yang 1%-5%.

Described infant eczema maintenance cream also includes following constituents:

Repair composition allantoin 0.1%-0.5%, nicotiamide 1%-5%, vitamin e 0.1%-0.5%, hydroxy phenylpropionyl amine benzene first Sour 1%-5%, Phosphoric acid monohexadecyl ester potassium 1%-5%, glyceryl stearate/peg-100 stearate 1%-5%, xanthan gum 0.1%-0.5%, methyl hydroxybenzoate 0.1%-0.5%, Methylisothiazolinone 0.1%-0.5%, glycerol 10%-30%, gluceptate sodium 0.01%-.0.05%, polyacrylamide 1%-5%, hyaluronate sodium 0.01%-.0.1%, cetearyl alcohol 1%-5%, surplus is Water.

Compared with prior art, the invention has the advantages that

The present invention is that one kind can improve skin sense, skin is not almost stimulated simultaneously and safety eczema repairing paste, can be in skin Surface forms membrane structure, similar natural biological sebum system.These thin film have good water holding capacity, so that sebum layer is had long-acting Moisturizing power, and the repairing paste of the present invention can form the gel structure of three-dimensional, contributes to the long-term stability of system, and can shape Become the skin sense of pleasant, protective barrier can also be formed in skin surface, to skin almost nonirritant.

Specific embodiment

For the ease of it will be appreciated by those skilled in the art that being described in further detail to the present invention by the following examples, but The present invention is not limited only to this.

A kind of preferred embodiment of the present invention:

A kind of infant eczema cream containing various plants oil maintenance composition, its raw material proportion of composing configuration by weight percentage For:

Material name Material Percentage

Lanoline 1

Shea butter 15

Camellia oil 3

Seed oil of Moringa oleigera 6

Glyceryl stearate/peg-100 stearate 2.5

Methyl hydroxybenzoate 0.1

Cetearyl alcohol 2.0

Calm yang(wax) 3.0

Water 39.68

Xanthan gum 0.3

Glycerol 15

Allantoin 0.2

Phosphoric acid monohexadecyl ester potassium 1

Gluceptate sodium 0.02

Nicotiamide 3

Polyacrylamide 1.3

Hyaluronate sodium 0.05

Methylisothiazolinone 0.1

Hydroxy phenylpropionyl amine benzoic acid 1

calm yang 3

Lin Lan moistens dew 0.5

Tocopherol (vitamin e) 0.25

Wherein calm yang(wax) and calm yang all purchase in Guangzhou Rui Yu Chemical Industry Science Co., Ltd.calm yang And the main component of calm yang is all: Herba Centellae extract, Flos Matricariae chamomillae flower extract, rosemary leaf extract, Folium Camelliae sinensis (wax) Extract, the mixture of Radix Scutellariae root extract, Glycyrrhiza glabra L. root extract and Rhizoma Polygoni Cuspidati root extract, the former is Oil soluble materials, The latter is water-soluble material；

Wherein Lin Lan profit dew is purchased in Beijing Orient Miao Sen bio tech ltd.The main component of Lin Lan profit dew is Dendrobium nobile Lindl stone Dry measure used in former times stem extract, Aloe vulgariss leaf extract, Radix Sophorae Flavescentiss root extract, lycium barbarum berry extract and Echinacea angustifolia extract.

Raw material is added in container by said ratio, so that it is mixed with suitable environmental condition, can during preparation Using any conventional mixing apparatus well known in the art, such as: emulsifying homogeneous pot etc..Need oil soluble and water-soluble during mixing Distinguish Hybrid Heating to 80 DEG C, then oil phase is mixed with water conjunction stirring homogenizing, cools to addition plant extract when 45 DEG C.

The concrete grammar of zest test-multiple acute skin irritation test and result are as follows:

Tested material: in this test tested material be a kind of containing various plants oil infant eczema maintenance cream, without dissolving without Dilution.

Laboratory animal and feeding environment:

Experimental animal used in this test be grow up, health, the Cavia porcelluss body weight (250～300g) of skin zero damage, female With male, but jenny should unpregnancy and not farrowing.Experimental animal at least with 4, such as to clarify some can Doubtful reaction then needs to increase experimental animal number.Experimental animal answers single cage to raise, and before test, animal is (real in experimental animal room environment Test room temperature: 20～24 DEG C, relative humidity 60～70%) at least adapt to the 3d time.Experimental animal and experimental animal room should accord with Close national respective specified.From conventional feed, drinking-water does not limit.

Repeatedly irritation test step:

Before 1 test, the hair of experimental animal back spinal column both sides is cut, unhairing scope is respectively 3cm × 3cm, application area 2.5cm ×2.5cm.

2 take repairing paste about 0.5g to be applied on the skin of side, and opposite side is not smeared as blank.Smear 1 daily Secondary, continuously smear 14d.From the beginning of second day, before smearing every time, answer cropping, remained with water or nonirritant solvent cleaning tested Thing.Observed result after one hour, scores by table 1；

Table 1 skin wound repair scores

Dermoreaction	Scoring
		Erythema and eschar are formed
No erythema	0
		Slight erythema (visible reluctantly)	1
Substantially erythema	2
		Moderate ~ severe erythema	3
Severe erythema (aubergine) is formed to slight eschar	4
Edema is formed
		No edema	0
Slight edema (visible reluctantly)	1
		Mild edema (cutaneous protuberance is clear-cut)	2
Intermediate edema (cutaneous protuberance gets over 1mm)	3
		Severe edema's (cutaneous protuberance is more than 1mm, expanded range)	4
Top	8

Note: check plot and trial zone are equally processed.

Evaluation of result: calculate every animal average integral daily by following equation, skin irritation intensity is judged with table 2.Examination Test and the results are shown in Table 3；

Daily every Evaluation integration=

Table 2 skin irritation strength grading

Integral mean value	Intensity
		0～＜ 0.5	Nonirritant
0.5～＜ 2.0	Slight stimulation
		2.0～＜ 6.0	Medium zest
6.0～8.0	Strong and stimulating

Table 3 result of the test

As can be seen here, this soothing oil is nontoxic to skin non-stimulated.

Questionnaire survey tried out by eczema maintenance cream

20 parts of questionnaire is provided in this test altogether, and evaluation index includes product mildness, comfort, spreadability, moistens degree, releives Effect etc., final appraisal results adopt arithmetic average Data-Statistics, and result is as shown in table 4 below:

Table 4 questionnaire survey statistical table

Project	Mildness	Comfort	Spreadability	Moisten degree	Releive effect
						Score value	4.8	4.5	4.4	4.5	4.6

Note: in table, evaluation result adopts 5 points of systems, divides from 1-5, it is very poor, poor, general, good, fine to be followed successively by.

As shown in Table 4, this eczema ointment service condition is good, and all more than 4.0, most subjects think that this is wet to statistical Rash maintenance cream does not gently stimulate, moist non-greasy, and smear is preferably, good with rear antipruritic effect, and multiple skin discomforts are all had not Wrong effect of releiving.

A kind of infant eczema maintenance cream containing various plants oil of the present invention meets national industry mark through inspection Standard, its indices complies fully with sanitary quality standard and the security requirement of national regulation.

Shea butter has the skin-care effect of moisturizing and nourishing, and its indices is very close to human secretory oils and fatss index, Contain the abundant non-saponified composition being extremely easy to absorption of human body, abundant fat and fatty acid, there is the pretty good moist benefit of comparison Water function.Shea butter contains substantial amounts of unsaponifiable lipid, can provide abundant vitamin a, d, e, f etc. for skin, to skin The enough nutritional labeling of supplement, more can effectively help cell more raw promotion microcirculation, can effectively prevent skin ageing, The problems such as be dried, burst, meanwhile, shea butter also has the effect promoting the even healing of tiny wound.Secondly shea butter energy Enough it is effectively isolated ultraviolet, have a kind of natural sun-prevention composition-cinnamic acid in shea butter, it can absorb the uvb in sunlight Ultraviolet, is that skin provides protection from Exposure to Sunlight infringement.The natural emulsion that it contains can help the skin that prevention causes because of light Tender subject.Furthermore shea butter has the antianaphylactic special efficacy of antiinflammatory, because shea butter is natural plant essence, so Stimulation will not be produced or cause skin sensitive for skin, care skin that can be gentle, therefore it is relatively specific for weakness Sensitive part, the plant sterin composition especially wherein containing, can have good antiinflammation to compromised skin.

Lanoline is the oiliness secretions being deposited on Pilus Caprae seu Oviss root secreted by the sebaceous gland of sheep, is by liquid and wax-like The complex mixture that hydroxy ester is constituted；A series of courses of processing such as reclaim, refine and can be made up through wool grease scouring, thick fat The anhydrous lanolin of grade.The complex mixture that lanoline is made up of multiple senior polyol fatty acids.Wherein ester content is 94%, The content of free alcohol, free acid and hydrocarbon is respectively 4%, 1% and 1%.In ester, non-hydroxyl ester accounts for 60%, and hydroxy ester accounts for 40%；In ester Lanonol and lanolin fatty acid respectively account for 50%.Different from general oils and fatss, do not contain triglyceride in lanoline, there is no free fatty yet, Therefore lanoline is a kind of wax rather than fat composition.Lanoline has good emulsifying and osmosiss, can be inhaled by skin and hair Receive, and mutually can be used in mixed way with multiple chemical compositions, be a kind of good natural cosmetics raw material, be characterized in moisturizing, moist, Fine and smooth, property is gentle.The lubricant component of lanoline and human body itself secretion extracted from sheep's wool is closest, and its surface is tied Structure is well suited for the mankind and uses.

The main component of Camellia oil is the unsaturated fatty acid based on Oleic acid and linoleic acid, content up to more than 90%, Oleic acid content has exceeded 80%；Containing abundant vitamin a, d, e, k, carotene and the thing such as micro Squalene, flavone, Saponin Matter, can effective protection skin, especially can prevent skin injury and aging, help water lock moisturizing.The vitamin a energy being wherein rich in Enough skin moistening drying, prevent skin wrinkling；Vitamin d can promote body metabolism, protection and strengthening skin elasticity, prevention The generation of little wrinkle；Vitamin e can blood circulation promoting unimpeded, skin aging and flexibility decrease always；Vitamin k can promote Make skin have natural elasticity, absorb subcutaneous unnecessary fat.Camellia oil molecular structure is small, can penetrate skin corium it is easy to Skin absorption, and salubrious do not stick greasy, for deep layer the repair ability of skin itself can be waken up in infant product, make impaired after Skin recover natural elasticity, gloss and tender.

Seed oil of Moringa oleigera has antibacterial, anti-inflammatory anti-itch effect well；Being capable of uvioresistant and the guarantor to ultraviolet injury Shield acts on；There is the protection to skin trauma and repair, more have outstanding non-oxidizability, be beneficial to stablizing of formula.Peppery The bacteriostasis of wooden seed oil are primarily due to it and contain 4- α-l- Fructus rhamni (Rhamnus davurica Pall.) glycosyloxy benzene acetonitrile composition and pterigospermin composition.Moringa seeds Oil to the erythrasma disease leading to human body skin tinea and is sent out skin ulcer microsporum and can be caused people's parapneumonia, urinary tract infection, wound Infection and the bacillus pyocyaneus of septicemia and staphylococcus aureuses are respectively provided with good inhibitory action, it are directly applied to little wound With prevention of inflammation and infection suppurates can be prevented on mouthful, be one kind safely and efficiently Vegetable oil lipoprotein.

Calm yang(wax) it is plant mixture lipophilic component, calm yang is plant mixture water-soluble composition, is suitable The suitable plant component to skin function with maintenance effect includes, calm yang or calm yang(wax), it is concrete Group be divided into Herba Centellae extract, Flos Matricariae chamomillae flower extract, rosemary leaf extract, Glycyrrhiza glabra L. root extract, Radix Scutellariae root extract, Rhizoma Polygoni Cuspidati root extract and Folium Camelliae sinensis extract.There is in the present composition plant mixture oil soluble of maintenance effect to skin function Composition is the new breakthrough made on the basis of original water soluble ingredient, and this composition can preferably protect the work(of seven big plant components , so as to effect is more stable, more notable, safety is higher for effect.

Lin Lan profit dew is that have three-dimensional moisturizing, and three-dimensional moisture-keeping efficacy is added with the plant improving skin transepidermal water content Agent, be specifically.This composition is mainly by Dendrobium nobile stem extract, Aloe vulgariss leaf extract, Radix Sophorae Flavescentiss root extract, Ningxia Fructus Lycii berry extract and Echinacea angustifolia extract combine.This composition combines the thought of the traditional Chinese medical science " overall, dialectical ", according to " monarch, Minister, help, make " the principles of formulating prescriptions, the work(taking Dendrobium nobile fluid infusion to promote the production of body fluid, adopt the power of Radix Sophorae Flavescentiss heat clearing and inflammation relieving, receive Echinacea purpurea Moench solid water Accumulateing of shield screen, receives Aloe vulgariss, lycium barbarum supports the benefit of profit YIN nourishing, by optimizing the ratio between component, realizes prescription and works in coordination with Potentiation.Lin Lan profit dew can be effectively increased aquaporin aqp3 and express in cell, thus strengthening water between skin epidermis cell The transport capacity divided, improves the content of skin transepidermal water, has quick, the long-acting effect improving skin moisture, simultaneously The activity of hyaluronidase can effectively being suppressed, reduce hyaluronic acid degradation, thus maintaining the barrier function of skin, and then promoting Skin Cell to the absorption of other effective ingredient in formula and utilization, thus improving skin resistivity to external world.

The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with Modify, all should belong to the covering scope of the present invention.

Claims (2)

1. a kind of containing various plants oil infant eczema maintenance cream it is characterised in that: described infant eczema maintenance cream is It is prepared from by the method for following raw materials configuring in proportion conventional preparation cream:

Vegetable oil lipoprotein shea butter 10%-30%, Camellia oil 1%-5%, seed oil of Moringa oleigera 5%-10%

Animal raw fat lanoline 1%-5%

Plant mixture lipophilic component calm yang(wax) 1%-5%

Plant additive Lin Lan profit dew 0.5%-1.0%

Plant mixture water-soluble composition calm yang 1%-5%.

2. according to claim 1 a kind of containing various plants oil infant eczema maintenance cream it is characterised in that: described Infant eczema maintenance cream also includes following constituents:

Repair composition allantoin 0.1%-0.5%, nicotiamide 1%-5%, vitamin e 0.1%-0.5%, hydroxy phenylpropionyl amine benzene first Sour 1%-5%, Phosphoric acid monohexadecyl ester potassium 1%-5%, glyceryl stearate/peg-100 stearate 1%-5%, xanthan gum 0.1%-0.5%, methyl hydroxybenzoate 0.1%-0.5%, Methylisothiazolinone 0.1%-0.5%, glycerol 10%-30%, gluceptate sodium 0.01%-.0.05%, polyacrylamide 1%-5%, hyaluronate sodium 0.01%-.0.1%, cetearyl alcohol 1%-5%, surplus is Water.