CN110368347A - Anti-ageing reparation double-layer bi-color essence of one kind and preparation method thereof - Google Patents
Anti-ageing reparation double-layer bi-color essence of one kind and preparation method thereof Download PDFInfo
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- A61Q19/08—Anti-ageing preparations
Abstract
A kind of anti-ageing reparation double-layer bi-color essence of the invention, it is made by following raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, beta carotene, jojoba seed oil, camellia seed oil, oat kernel oil, allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride, parahydroxyacet-ophenone, propylene glycol, arginine, avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan profit dew, septuple anti-sensitizer, 1, 2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400, water-soluble hesperidin and deionized water.The present invention it is anti-ageing repair double-layer bi-color essence avenabeta glucosan and SYN-COLL promote skin in collagenic protein generation, repair skin deep wrinkles, improve skin roughness, inhibit in terms of play significant effect.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to anti-ageing reparation double-layer bi-color essence of one kind and preparation method thereof.
Background technique
With the growth at age, our body and histoorgan is all constantly weak.Skin is as the maximum device of human body
Official shows as microgroove, wrinkle, drying, relaxation, colour of skin dimness and color spot etc., a variety of skin problems also in continuous aging.Skin
Epidermis, corium and subcutaneous tissue can be divided into.Between surface layer and corium, there are also one layer to be referred to as epidermal-dermal interlayer,
Referred to as (DEJ).
Epidermis plays the role of barrier and protection, counts for much whether dry skin with epidermis.Collagen in corium
To the elasticity of skin, plumpness plays the role of conclusive for albumen and elastin.And hyaluronic acid therein and other viscous
Polysaccharide is filled in skin corium, it is highly important that fibroblast, it is responsible for the update of extracellular matrix in dermal cell,
Be exactly collagen, hyaluronic acid these be all to be generated by fibroblast.The number of wrinkle in skin, every physics refers to
Mark (such as elasticity) is all determined by this layer.
DEJ layers play the role of linking epidermis and skin corium, allow skin to be less easy slack and undisciplined.Each layer of skin for
The skin of young state suffers from important function, all should conscientiously nurse.If being related to complete anti-aging process, have a lot of
Project need to consider:
1. moisturizing
2. epidermal barrier function is rebuild
3. anti-microgroove
4. anti-wrinkle
5. the elasticity of skin
6. skin is compact
7. contoured skin and volume
8. anti-oxidant
9. anti-saccharification
10. matrix protection
11. pore
12. color spot
13. anti-inflammatory
14.…
Each of the above step is some problems that skin can slowly occur during with aging, and needs to do
Skin care be directed to direction.However each step is carried out, it is all remarkable.If further that the means of these anti-ageing reparations and direction are comprehensive
Altogether, it rises to from the point of view of higher level, the skin care of anti-ageing reparation and technology realization means, is in fact exactly two aspects, on the one hand
It is: inhibits；On the other hand it is: promotes.
One, inhibit
With the aging of body, the reason of the influence of environment or gene, the cell and institutional framework of skin layers will point
It solves and changes, if these harmful variations can be inhibited, anti-ageing repair can be played.Meanwhile if it can inhibit
The internal factor that has an impact is carried out in some harmful outsides, also will be helpful to anti-ageing reparation skin problem.
Inhibit this one end, there are many things to need to be suppressed, for example aoxidize, free radical, Collagenase, elastin laminin
Enzyme, metallo-matrix proteases, fibrinolysin, saccharification etc...
Human body cell constantly suffers from the attack of free radical, and human body itself can also generate the antioxygen for resisting free radical naturally
Compound matter is exactly not enough in many cases.The oxidation resistance of human body is stronger, and body is more healthy, and skin is also better.
We can resist influence of a part of free radical to skin, such as the chemical conversion of antioxygen known to us by external application antioxidant
Point, including beta carotene, VC, VE, Q10 etc..This is also the ingredient added extensively in various cosmetic products.
Two, promote
The renewal speed of the cell of aging can be slack-off, and the speed for generating collagen and hyaluronic acid can all reduce.
So, if it is possible to which the work for promoting these aged cells accelerates renewal speed, then can play anti-ageing
The effect of reparation.For example promote the exchange of cell signal, to allow cell more energetically to work, promote collagen and elasticity
The generation of albumen promotes skin microcirculation etc..Ingredient relevant to promotion, including palmityl tripeptides -5, A alcohol, carnosine etc.
It is all the good hand of " promotion ".
Either inhibit or promote, wants that it is all to think and adhere to for a long time that any one step therein, which is carried out,
, accomplish in one move absolutely not.Promote this aspect, to promote the generation of collagen, or even generate compact effect.
So, there are also environmental factor, genetic factors can all influence the process of aging in addition to skin care.Specifically, diet,
Movement, environmental pollution, mood etc., each factor can interfere the anti-ageing war of skin, influence final skin condition.
Present invention relates to a kind of anti-ageing reparation double-layer bi-color essences and preparation method thereof, have anti-ageing reparation to make skin
With clinical trial discovery truly has good effect.
Summary of the invention
To achieve the above object, a kind of anti-ageing reparation double-layer bi-color essence of the present invention, is made by following raw material: ring five is poly-
Dimethyl siloxane/cyclohexasiloxane, dimethyl silicone polymer, beta carotene, jojoba seed oil, camellia seed oil, oat kernel
Oil, allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride, parahydroxyacet-ophenone, propylene glycol, arginine, oat
Beta glucan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan moisten dew, CalmYang, 1,2 oneself two
Alcohol, PEG-12 glycerol monolaurate, polyethylene glycol-400, water-soluble hesperidin and deionized water.
Preferably, anti-ageing reparation double-layer bi-color essence can be divided into six kinds of mixed raw material compositions of A, B, C, D, E, F, will
Each mixed raw material mixes step by step prepares the essence:
Wherein, include in A raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, β-Hu
Radish element, jojoba seed oil, camellia seed oil, oat kernel oil；
Include in B raw material: allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride；
Include in C raw material: parahydroxyacet-ophenone, propylene glycol；
Include in D raw material: arginine；
Include in E raw material: avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5,
Lin Lan moistens dew, CalmYang, 1,2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400；
Include in F raw material: water-soluble hesperidin.
The anti-ageing reparation double-layer bi-color essence, the proportion (mass percent) of each raw material are as follows:
Compared with prior art, using several there is anti-ageing skin to repair in the anti-ageing reparation double-layer bi-color essence of the present invention
The component of multiple effect is grouped mixing according to a specific ratio, by various experimental verifications, the anti-ageing reparation double-layer bi-color essence of the present invention
The generation of avenabeta glucosan and the SYN-COLL collagenic protein in promoting skin of element, improves reparation skin deep wrinkles
Skin roughness, inhibition skin allergy etc. play significant effect, than the moisturizing containing yeast dextran, hyaluronic acid
Stoste has effects that protrude in anti-ageing reparation skin, this is that the various components of entire essence are mixed with by several times in specific proportions
It obtains, complements each other, SYN-COLL promotion combines reaction with avenabeta glucosan, also the effect of promotion avenabeta glucosan
The effect of playing, optimal reparation skin can be obtained.
Detailed description of the invention
Fig. 1 is the skin roughness using anti-ageing reparation double-layer bi-color essence and blank cream containing oat beta-glucan
Compare effect picture；
Fig. 2 is using the anti-ageing reparation double-layer bi-color essence containing oat beta-glucan and containing yeast dextran, blank cream
Skin elasticity comparison effect picture；
Fig. 3 is using the anti-ageing reparation double-layer bi-color essence containing oat beta-glucan and containing yeast dextran, hyaluronic acid
Moistening effect contrast effect figure；
Fig. 4 is the anti-ageing molecular principle repaired collagen in double-layer bi-color essence and generate and prevent degradation of the present invention
Figure；
Fig. 5 is that SYN-COLL and avenabeta glucosan be combined with each other activation in anti-ageing the reparations double-layer bi-color essence of the present invention
The response diagram of avenabeta glucosan；
Fig. 6 is the anti-ageing chemical structural drawing for repairing SYN-COLL in double-layer bi-color essence of the present invention；
Fig. 7, which is that the present invention is anti-ageing, repairs the life for promoting collagen in double-layer bi-color essence in SYN-COLL efficacy in vitro
At；
Fig. 8 is keratinocyte under SYN-COLL efficacy in vitro pressure state in the anti-ageing reparation double-layer bi-color essence of the present invention
In to the protection schematic diagram of collagen；
Fig. 9 is that SYN-COLL and the in vivo efficacy of blank cream are being releived in the anti-ageing reparation double-layer bi-color essence of the present invention
Wrinkle and the contrast effect figure for reducing wrinkle depth；
Figure 10, which is the anti-ageing in vivo efficacy for repairing SYN-COLL in double-layer bi-color essence of the present invention, wrinkle and to be subtracted releiving
The front and back using effect comparison diagram of few wrinkle depth；
Figure 11 is the anti-ageing in vivo efficacy for repairing SYN-COLL in double-layer bi-color essence of the present invention in confrontation and smooth skin
The effect of skin contrast test figure；
Figure 12 is SYN-COLL and palmityl tripeptides -5 effect in vitro in anti-ageing the reparations double-layer bi-color essence of the present invention
On contrast test figure；
Figure 13 is that SYN-COLL is detected in the synthesis of stimulation hyaluronic acid in the anti-ageing reparation double-layer bi-color essence of the present invention
Figure；
Figure 14 is that SYN-COLL is transparent in stimulating old fibrocyte in the anti-ageing reparation double-layer bi-color essence of the present invention
The contrast test figure of matter acid；
Figure 15 is SYN-COLL in the anti-ageing reparation double-layer bi-color essence of the present invention the effect of inhibiting proinflammatory cytokine
Schematic diagram.
Specific embodiment
A kind of anti-ageing reparation double-layer bi-color essence of the invention, is made: ring five dimethyl silicone polymer/ring by following raw material
Own siloxanes, dimethyl silicone polymer, beta carotene, jojoba seed oil, camellia seed oil, oat kernel oil, allantoin, EDTA-
2NA, glycerol, propylene glycol, glycine betaine, sodium chloride, parahydroxyacet-ophenone, propylene glycol, arginine, avenabeta glucosan, oligopeptides -1,
Dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan profit dew, septuple anti-sensitizer, 1,2 hexylene glycols, the PEG-12 glycerol moon
Cinnamic acid ester, polyethylene glycol-400, water-soluble hesperidin and deionized water.
Preferably, anti-ageing reparation double-layer bi-color essence can be divided into six kinds of mixed raw material compositions of A, B, C, D, E, F, will
Each mixed raw material mixes step by step prepares the essence:
Wherein, include in A raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, β-Hu
Radish element, jojoba seed oil, camellia seed oil, oat kernel oil；
Include in B raw material: allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride；
Include in C raw material: parahydroxyacet-ophenone, propylene glycol；
Include in D raw material: arginine；
Include in E raw material: avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5,
Lin Lan moistens dew, septuple anti-sensitizer (CalmYang), 1,2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400；
Include in F raw material: water-soluble hesperidin.
Wherein, septuple anti-sensitizer includes: chamomile, Radix Glycyrrhizae, centella, rosemary, Scutellaria baicalensis, tea and Japan tiger
Cane.
The anti-ageing reparation double-layer bi-color essence, the proportion (mass percent) of each raw material are as follows:
Preferably, the anti-ageing reparation double-layer bi-color essence, the proportion (mass percent) of each raw material are as follows:
The effect of detailed description below group subassembly A and E:
The effect of component A, illustrates:
1, beta carotene: beta carotene is the natural products obtained from Dunaliella salina, it, which is otherwise known as, ties up life
The plain source A, chemical structure are joined end to end by 4 isoprene double bonds, belong to tetraterpenes compound, respectively have at the both ends of molecule
1 β-purple trailing plants ketone ring, center burst can produce 2 vitamin A molecules, and have between multiple double bonds and double bond altogether in structure
Yoke.Such system is more stable, and chromogenesis is greatly reinforced, and the more, dark color movement is more significant for conjugated double bond.
The structure of exactly this conjugated double bond, so that beta carotene has the characteristics that following and effect:
1.1. Dunaliella salina accumulates a large amount of carrotene, and carotene carotene content is up to the 14% of dry cell weight in cell
(mass fraction), therefore, it has become the best algae of production natural Beta-carotene.Its not still natural antidotal agent, also
The effect of cleaning blood and blood vessel well.Because it can allow the capillary of hardening to restore life, restore the soft of capillary
Toughness.And complete cell and treatment damage cell can be protected.
1.2. antioxidation.Beta carotene can safeguard that microsomal membrane is complete using itself unique chemical structure characteristic
It is whole, and cytomicrosome film integrality can prevent oxygen radical from generating, and the electronics and removing freedom that stabilized radical is extra
Base delays body catagen speed, prevents skin aging.
1.3 substances with physiological activity.It can be converted to vitamin A in vivo, epithelial tissue seborrheic keratosis can be treated, maintain
The integrality of skin and mucous membrane layer, prevent dry skin, it is coarse.Promote skin growth development, effectively facilitates Skin Cell health hair
It educates.
The effect of component E, illustrates:
Illustrate several core components in component E individually below: avenabeta glucosan, oligopeptides -1 and SYN-COLL are (sweet
Oil, palmityl tripeptides -5, water) the effect of mechanism.
1. avenabeta glucosan:, β-(1 → 3,1 → 4) glucan in oat sugared for natural non-starch class water-soluble plant
Abbreviation avenabeta glucosan is a kind of non-starch polysaccharide for being present in oat endosperm and gluten cell wall.It is by monomer β-D-
Glucopyranose is got up a kind of high molecular polymer to be formed by β-(1 → 3) and β-(1 → 4) glucosides key connection, is a kind of
The lesser short chain glucan of relative molecular mass, the variation range of relative molecular mass are 5300-257200, and oat β-Portugal is poly-
It possesses excellent senile-resistant efficacy to sugar, can smooth fine wrinkles, improves skin elasticity, improves dermatoglyph degree；With only
Special straight-chain molecular structure, imparts good Transdermal absorption performance；Promote fibroblast to synthesize collagen, promotes wound
Healing repairs impaired skin, gives skin and moisten smooth sense of touch such as silk.
Avenabeta glucosan is a kind of pure natural polysaccharide from oat, using the advanced biotechnology of modernization and solely
Special product processes are process, and do not add any organic solvent in production process, guarantee Product Green safety.Oat β-
Glucan has very outstanding anti-aging properties, and tightening that can be instant and softening fine wrinkles improve dermatoglyph degree.Swallow
Wheat beta glucan unique 1,3 and Isosorbide-5-Nitrae straight-chain molecular structure, Transdermal absorption performance is good, and the release that can be used as active ingredient carries
Body.Avenabeta glucosan has long-term efficient moisture-retention performance, can assign skin and moisten smooth sense of touch such as silk.Oat β-Portugal
Glycan can also significantly improve the immune function of skin, and enhancing improves the ability that skin resists environmental stimuli to skin sparing, promotees
Into wound healing, desalinate scar color.
The property of avenabeta glucosan
Avenabeta glucosan is a kind of active cosmetic additive of multifunctionality, mainly extracts and divides from oat bran
From obtaining.Avenabeta glucosan is a kind of by 1,3 and Isosorbide-5-Nitrae position glycosidic bond, i.e. cellotriose connects sugared single with cellotetrose
The polysaccharide of body composition；The ratio between (l-3) glycosidic bond and (l-4) glucosides linkage content are about 3: 7 in beta glucan.80 years 20th century
Dai Hou, Wood et al. are shown with specificity enzyme hydrolysis: β-(1-4) and β-(1-3) glycosidic bond are in space in avenabeta glucosan
Upper is in chain type single coil configuration.Wherein, there is every 2~3 β-(1-4) glycosidic bonds for 85% or more avenabeta glucosan molecule
There is β-(1-3) glycosidic bond, a large amount of hydrophilic radicals are evenly distributed on dextran backbone.It is most main that product has merged mesh the first two
The anti-aging and natural development trend wanted.
The cosmetic property of avenabeta glucosan
1, excellent Transdermal absorption performance
β-(1-4) and β-(1-3) glycosidic bond are spatially in chain type single coil configuration in avenabeta glucosan, can be quick
Ground penetrates skin, smoothes away wrinkles.It has delivered in " international cosmetic science " (volume 27, the 5th phase) researcher to oat β-Portugal
The research achievement of glycan Transdermal absorption.After labelled atom is added in 0.5% beta glucan by experiment, it is applied to the abdomen of volunteer
On skin, dosage 5mg/cm2.As a result, it has been found that avenabeta glucosan can penetrate into skin quickly through intercellular lipid matrix
Deep layer.
Compared with yeast beta-dextran, avenabeta glucosan molecule is straight-chain molecular structure.Unique space structure makes swallow
Wheat beta glucan has excellent Transdermal absorption performance, gives the directly effective nutritional supplementation of skin, its cosmetics is tested in experiment
Effect is about twice of yeast beta-dextran.Avenabeta glucosan, which can rapidly promote, is immunized and promotes fibroblastic life
It is long, enhance skin elasticity, delay skin aging；And avenabeta glucosan can promote fibroblast to synthesize collagen,
Promote wound healing and reduce scar, dry, thinning skin is made to seem and significantly improve.
2, anti-senescence function
2.1 improve skin roughness
Human test's experiment.
(1) laboratory apparatus: test instrument for skin roughness；(2) experimental period: 8 hours；(3) volunteer: 10, men and women is each
Half.(4) effective ingredient amount contained by each cream: 1. avenabeta glucosan 5%；2. blank cream.
Experimental result is as shown below.After continuous use 8 hours, it can be obviously improved the roughness of skin, tested
Room measurement, under same use condition, avenabeta glucosan can reduce skin roughness about 43.7%.Shown in referring to Fig.1, this hair
The bright essence containing avenabeta glucosan the skin roughness the effect of on than blank cream the effect of improve obvious, have significant
It is promoted.
2.2 increase skin elasticity
Shown in referring to Fig.1, in human test's experiment, the contrast effect schematic diagram of skin roughness.
(1) laboratory apparatus: skin elasticity tester.
(2) experimental period: 8 hours.
(3) volunteer: 10, men and women is fifty-fifty.
(4) effective ingredient amount contained by each cream:
1. avenabeta glucosan 5%；
2. yeast beta-dextran 5%；
3. blank cream.
Experimental result is as shown below.From experimental result it can be seen that avenabeta glucosan is bright in terms of improving skin elasticity
It is aobvious to be better than yeast beta-dextran.It is straight chain single coil configuration this is mainly due to the space conformation of 1. avenabeta glucosan, and ferment
There are many branch of female beta glucan, hinder the Transdermal absorption of yeast beta-dextran.2. the molecular weight of avenabeta glucosan is less than
Yeast beta-dextran, it is easier to which penetrate to the skin deep layer, to have very greatly in terms of increasing skin elasticity compared with yeast beta-dextran
Advantage.From Fig. 2 using the skin elasticity comparison diagram of essence of the present invention and yeast dextran, blank cream, it is evident that this
The effect of inventing containing avenabeta glucosan essence to skin elasticity is obvious, improves obviously than other two kinds of skin care item, has aobvious
It writes and is promoted.
3. promoting collagen synthesis, impaired skin is repaired
3.1 promote the synthesis of collagen
Animal testing experiment:
Experiment uses 1% avenabeta glucosan；Control group is 1% hyaluronic acid.
Rat is divided into control group and avenabeta glucosan group, every group 8, is pushed away respectively with pet in experimental animal rat
The depilation of ridge two sides, lose hair or feathers range 3cm × 3cm.It is first cleaned with clear water in back two sides without hair-fields, then chooses every rat
Back two sides are without the skin among hair-fields, experimental point about 2cm × 2cm, and control group is without any processing in addition to clear water cleans；Oat
Beta glucan group is coated with isodose avenabeta glucosan preparation, once a day.It draws materials within 7 days after coating, detects glue in skin
Former protein content.
Experiment finds that Collagen I and Collage Ⅲ glomerulopathy content are apparently higher than control group in avenabeta glucosan group rat skin, and
Significant difference.It proves that avenabeta glucosan can promote the synthesis of a variety of collagens, effectively slows down cutis laxa and aging,
Enhance skin elasticity, repairs the damage due to the growth at age and the influence bring of environment to skin.
3.2 improve the immunity function of skin
Many famous research institutions in the world, including medical college, Harvard University, Tu Lun university, University of Washington and beauty
Air force, state radiobiological studies are waited and are all confirmed, beta glucan has the function of significantly improving immunity.
Research shows that beta glucan can improve the phagocytic activity of macrophage, the immunocyte that can accelerate to determine crowd is to thin
The reaction of bacterium infection, and the position of bacterium infection is controlled, restore infection face as early as possible.
It is thin that beta glucan is bundled in the most abundant immunocyte neutrophil(e) granule in human body natural's immunocyte by researcher
On the receptor of born of the same parents, as a result beta glucan enhances the killing ability of neutrophil cell, and promotes neutrophil cell and exist
It is mobile towards infection position under the action of hematoglobin protein, and rapid reaction is made to outer infections in first time.
By the neutrophil cell that beta glucan is equiped with arms, the ability for perceiving infection position is also enhanced, and help in thermophilic
Property granulocyte finds master pulse of the bacterium in infected tissue, faster reaction can be made to infection site, as early as possible bacteria removal
It infects and makes the rehabilitation of infection face.
3.3 good skin repair functions
Avenabeta glucosan is used for wound and burn treating by FDA and European Union's approval, and releases associated treatment product.Experiment
The result shows that pain, and speed of wound healing fast 15% or so can be reduced rapidly using avenabeta glucosan.
3.4. efficient moisture-retention effect
Human test's experiment:
(1) laboratory apparatus: moisture of skin tester.
(2) experimental period: 4 hours；
(3) volunteer: 10, men and women is fifty-fifty；
(4) effective ingredient amount contained by each cream: 1. avenabeta glucosan 3%；
2. hyaluronic acid 0.1%；
3. yeast beta-dextran 3%.
Avenabeta glucosan has excellent performance of keeping humidity, its own unique film forming characteristics can assign skin smooth
Appearance.From experimental result this it appears that the moistening effect of avenabeta glucosan is better than hyaluronic acid and yeast beta-dextran,
And the performance of keeping humidity of avenabeta glucosan is close to twice of yeast beta-dextran.This may be due to avenabeta glucosan point
The contained a large amount of hydrophilic radicals of son itself are exposed, and caused by the hydrophilic radical of yeast beta-dextran is containing.
Referring to shown in Fig. 3, by containing oat beta-glucan, yeast dextran, three kinds of different components of hyaluronic acid essence
Moistening effect comparison, the effect of moistening effect and moisture of skin, the essence containing avenabeta glucosan be better than β containing yeast-Portugal
The essence of glycan, the essence containing yeast beta-dextran are better than the essence containing hyaluronic acid.
3.5. release performance is controlled
Beta glucan in oat can form nanostructure, make active constituent slow release in cosmetics, and small point of nanometer
Minor structure makes it easier to skin permeation skin corium, locks moisture, moistening effect it is further preferred that.
2. oligopeptides -1: promoting dermal cell growth, collagen regeneration, repair damaging skin surface；Enhancing skin supports
Drag improves skin quality, conditioning skin sensitivity, stimulation, allergy, rubescent, pruritis；Skin Cell vigor is improved, cell is promoted
Metabolism accelerates the metabolism of surface layer color spot, bright color, makes skin translucent luster；Promote Skin Cell to secrete collagen, mentions
High skin elasticity enables compact smooth, the desalination dry line of microgroove of skin；Promote Skin Cell to secrete hyaluronic acid, improves skin water lock
Ability enables skin water tender soft and moist.
The brief introduction of 2.1 oligopeptides -1
Oligopeptides -1 is a tri-peptide molecule, and sequence is GHK.It is naturally occurring in blood, saliva and the urine of people.20
Concentration of the GHK in blood is 200ng/mL (10-7M) when year, and concentration drops to 80ng/mL when by 60 years old.This
Kind decline phenomenon be remarkably decreased with the neomorph ability of people it is directly related.Dr.LorenPickart divides first within 1973
From GHK-Cu has been arrived, it is the tripeptides object found in the active material that research equally works to ageing tissues and young tissue
Matter, next research have shown that the sequence of this tripeptides is Gly-His-Lys, and have with copper ion very strong
Affinity forms GHK-Cu compound.Research has shown that GHK is functioned in the form of forming compound with copper ion.
The feature of GHK maximum is to form compound with Cu ion, this is very important, because having in human body and on skin
Many important enzymes need Cu ion, these enzymes play a role in connective tissue formation, anti-oxidative defense, cellular respiration.Cu
Ion also plays semiotic function simultaneously, can influence the behavior and metabolism of cell.Such as enough Cu ions are that stem cell increases
Grow the signal with tissue repair.GHK also helps to reduce the Cu ion concentration of free state, prevents oxidative damage.In addition to Cu ion
In conjunction with GHK can also neutralize a toxin, especially those toxin generated during lipid peroxidation, and GHK is a kind of very high
The antioxidant of effect.Last GHK can be used as cell adhesion molecule, cell adherence can be helped into extracellular matrix, help cell
Migration, differentiation, repairs Skin Cell at proliferation.
2.1.1.GHK being regenerated with skin progenitor cell
Skin regeneration depends on the survival ability and proliferative capacity of skin progenitor cell.Skin hyperplasia starts from basal part and is attached to
Keratinocyte on basilar memebrane.It begins to carry out terminal differentiation when cell leaves basilar memebrane.Stem cell has unlimited self-renewing
Ability, however their multiplication potentiality declines year by year with advancing age.Concentration of the GHK-Cu in 0.1-10micromolar
The marker such as integrin in epidermal stem cells and the expression of the marker p63 in basal layer keratinocyte, root can be improved
According to the statement of author, these molecules are the marks that basal layer keratinocyte Stem Cell Activity improves.Therefore integrin and p63 are perhaps
It is the related target that GHK adjusts skin regeneration.Recent study has confirmed, the stem cell of people GHK gel pre-processes can be with
The secretion of such as VEGF, bFGF of angiogenic factors etc. is improved, and is dose-dependant pattern.When the anti-integration of stem cell
When the processing of plain antibody, above situation no longer occurs, and implies that effect of the GHK on stem cell is occurred by integrin signaling approach
's.
Effect of the GHK and IL-6 in skin repair
Wound healing and skin regeneration include anti-inflammatory response, cell Proliferation, cell migration and matrix remodeling etc..Excessive inflammation
Disease reaction can postpone the healing of wound and lead to the formation of scar.In the tooth fibroblast of normal person, copper peptide complexes
GGH, GHK etc. can reduce the secretion of the IL-6 of TNF-alpha induction.And other copper complexs are without this effect.Researcher pushes away
The anti-inflammatory agent that disconnected GHK and GHK-Cu can be used as substitution glucocorticoid uses.
2.1.2.GHK with DNA damage reparation
GHK can restore fibroblastic vigor of raying.Researcher is with from being exposed to radiation environment
The neck fibroblast of (5000rad) is added to GHK (10-9M) in serum free medium.GHK is not added in control group.Right
Although can survive and breed according to cell in group, their growth curve and normal cell is entirely different.Raying cell
In the detection for 24 hours with 48h compared with normal cell growth delay.And it grows faster with the irradiated cell that GHK is handled and (shows
It is similar to normal cell).Furthermore the processed cell of GHK produces more growth factors, these factors are for wound healing
It is extremely important.Fibroblast is the main cell of wound healing and regeneration.Their not only synthetic cell epimatrixs it is each
Kind ingredient, also generating a large amount of growth factor, (these factors adjust migration and proliferation, angiogenesis, epithelialization of cell etc.
Deng).The DNA of radiation injury cell, and then damaging cells function.Since GHK can restore the function of raying cell, Wo Menyou
Reason believes that GHK has the ability for repairing damaged dna.The software genetic analytical tool developed using Broad research institute: gene connects
Logical figure research GHK discovery: GHK can be improved the expression with 47 genes of DNA damage reparation row pipe and lower the table of 5 genes
It reaches.
2.1.3.GHK: a kind of natural dermis restoration regulator
The healing of wound experienced with the next stage in skin: hemostasis, inflammatory reaction, granulation, scar are rebuild.Each stage
Need to coordinate cell interaction, therefore a large amount of bioactive molecule of separate sources guides cell to complete as expeditor
Whole process.Such as threshing immediately after injury, intra platelet free calcium growth factor transfer immunocyte to injured position.Angling is thin
Born of the same parents and fibroblast can also generate a large amount of cell factor, neutrophil leucocyte, macrophage and other called up to by traumatic part
The immunocyte of position produces corresponding cell factor.GHK is sequence rare in human protein；However, it is in extracellular base
In the protein of matter more common (ECM).GHK is the component part in 2 chain of a Collagen Type VI, and proteases for decomposing collagen will when injured
GHK is discharged into wound part.Another very famous glycoprotein for containing GHK is SPARC, it decomposes generation after injury
GHK-Cu.Protein releases a series of important regulatory molecules after hydrolyzing extracellular matrix proteolysis in other words, referred to as extracellularly
Matrix activin.These molecular activations or regulation dermis restoration process.Since GHK is deposited in extracellular matrix after being used as injury
Polypeptide sequence, then it is considered that it is a kind of natural dermis restoration agent.
By above to oligopeptides -1 the effect of mechanism elaborate, illustrate oligopeptides -1 be applied to essence in, with it
He mixes raw material, has effects that the remarkable efficacies such as skin repair and water lock outstanding, promotes the skin repair moisturizing of essence
Efficacy exertion.
3.SYN-COLL (glycerol, palmityl tripeptides -5, water): (bibliography: the medicinal and used for cosmetic activity of skin is few
Peptide patent No. CN 1582302A)
(CN1582302A) of the invention is related to medicinal, the medicinal and used for cosmetic active oligopeptide of skin and its derivative, peptides
Like object and its derivative and its application in the medicinal and used for cosmetic active compound of skin.
Oneself knows that the fundamental mechanism of skin aging occurs to hand between epithelial cell and connective tissue in extracellular matrix
In the so-called base layer of crunode.The regeneration of extracellular matrix is very important, and is in contact with it because this will be significantly affected
Cell behavior, the especially growth, migration of those cells, proliferation, form and function.In extracellular matrix at fiber
The collagen of cell synthesis and aging-related reduction, as a result cause the amount of the chemical substance as secreted by these cells to reduce.By
Contain about 80% collagen in skin protein, reduce can physics and physiology to skin for a small amount of natural of collagen concentration in the tissue
Characteristic generates apparent influence.
Katayama et al. (TheJournalofBiologicalChemistry, volume 268, the 14th phase, 9941-9944
Page, 1993) find that the minimum subfragrnent sequence of stimulation collagen and fibronectin is indicated by pentapeptide Lys-Thr-Thr-Lys-Ser.
The sequence of four or less amino acid has slighter effect of stimulation or does not have effect of stimulation.
European patent application WO00/15188 describes palm fibre and puts acylated pentapeptide, palmityl-Lys-Thr-Thr-Lys-Ser
The effect of ingredient as treatment skin aging, accelerating wound healing and increase moisture of skin.
Have been found that seleced new oligopeptides and its derivative and peptide analogues and its derivative (hereinafter referred to as " this hair
The compound of bright (CN1582302A) ") there is effect extra high medicinal and/or used for cosmetic, therefore particularly suitable for skin
Skin is medicinal and/or effective composition used for cosmetic.The compound diffusion of (CN1582302A) of the invention is rapid, and with enough
Concentration reaches intracellular action site by cell membrane, they can significantly improve the child of collagen and fibronectin herein.Therefore,
The compound on intracellular epimatrix of of the invention (CN1582302A) is applied with wonderful positive and irritant effects, and thin
Extracellular matrix has decisive impact the physics and physical appearance of skin, especially, with other changes known in the art
Conjunction object induces the synthesis to collagen more rapidly and more strong impulse compared to the compound of (CN1582302A) of the invention.It is described
(CN1582302A) compound of the invention to collage synthesis more rapidly and more strong impulse may be by decrease in molecular weight, ammonia
In base acid the introducing of N- methyl group and with such as aliphatic ester to the result for modifying synergistic effect obtained of amino acid.
But (CN1582302A) of the invention is not limited by such explanation.
Moreover, (CN1582302A) of the invention, which further relates to the compounds of this invention, is used to prepare promotion wound healing and stimulation skin
The application of skin moisturizing drug, and delay or treat skin aging, the especially method of the formation of wrinkle, the method includes
The compound of the present invention and/or composition of the invention are applied on skin.
SYN-COLL (glycerol, palmityl tripeptides -5, water) mechanism and dependence test.Fig. 4-15 is for SYN-COLL at this
The performance test of various aspects in anti-ageing reparation double-layer bi-color essence is invented, sampling is joined with the essence containing hyaluronic acid
Comparison is examined, is tested by a series of Experimental comparison, from effect mechanism, molecular structure, skin repair and moisture-keeping efficacy test etc.
Aspect is illustrated in the anti-ageing reparation double-layer bi-color essence of the present invention using SYN-COLL in essence, is pressed with other components
Special ratios mixing be combined with each other with avenabeta glucosan and activates avenabeta glucosan promotion effect obvious, in vitro in effect,
Generation and the efficacy exertion for promoting collagen, to the protection of collagen in keratinocyte under pressure state.After use
In vivo efficacy comparison on, the anti-ageing reparation double-layer bi-color essence containing SYN-COLL and blank cream are compared, contained
The anti-ageing reparation double-layer bi-color essence of SYN-COLL improves in releive wrinkle and reduction wrinkle depth, in confrontation and even skin
Obviously, the breakthrough of anti-wrinkle effect can be seen from using renderings.In addition, SYN-COLL can also stimulate hyaluronic acid and
Hyaluronic acid and inhibition proinflammatory cytokine play a role in old fibrocyte.
Shown in referring to Fig.1, promotes collagen to generate, prevent the schematic diagram of collagen degradation.
Referring to Figure 5, Fig. 5 is the process schematic of SYN-COLL stimulation TGF-8: the TGF-8 of inactivation and (LAP) are potential
Property GAP-associated protein GAP) under the reagentia of SYN-COLL or thrombospondin (TSP), the fiber in TGF-8 can be stimulated
The synthesis of collagen in cell, so that the function of activation TGF-8 is realized, in addition, TSP and LAP-TGF- β, which is combined, to be swashed
TGF-β living, SYN-COLL can be combined with similar approach, and effect is identical.
It is that SYN-COLL and palm fibre put -5 chemical structure schematic diagram of acyl tripeptides referring to shown in Fig. 6, wherein the ammonia of SYN-COLL
Base acid moieties, sequence:
Palm-lysine-valine-lysine-carboxyl, in addition, best infiltration can choose tripeptides small molecule and palm fibre is put
The reaction of acyl group group；
It is the schematic diagram that SYN-COLL efficacy in vitro increases collagen I synthesis referring to shown in Fig. 7, SYN-COLL stimulates glue
The test of former protein I synthesis is completed in the human fibroblasts of culture, and SYN-COLL is effective with dose-dependant sexual approach
Inducing collagen synthesis.
Referring to shown in Fig. 8, the efficacy in vitro of SYN-COLL, under pressure state in keratinocyte collagen protection,
Chemical induction (PMA) stress be after (24 hours), the expression of cell factor and MMP in normal human subject keratinocyte (NHK), with nothing
Stress cell compare, fluorescence intensity is multiplied (=1.00), through SYN-COLL handle cell do not show collagen drop
Solve enzyme and cell factor stress be shown in related is formationed (being multiplied less than 1) reference Fig. 9, and the in vivo efficacy of SYN-COLL has
There are anti-Zou and smooth effect, SYN-COLL has effects that smooth and reduction wrinkle depth of releiving as we know from the figure；
It is anti-Zou of SYN-COLL and smooth display effect shown in 0 referring to Fig.1, wherein the dosage of SYN-COLL is:
2.5%, as seen from the figure: SYN-COLL can significantly reduce wrinkle
It is the example of the in vivo efficacy confrontation and smooth wrinkle of SYN-COLL, as seen from the figure, deep layer wrinkle shown in 1 referring to Fig.1
Line significantly reduces in three months: entire skin appearance is improved, by 3D dermal imaging it is found that the texture of skin uses
Primos technology is indicated with different colours, wherein SYN-COLL dosage is 2.5%.
It is the efficacy in vitro comparison schematic diagram that SYN-COLL and palm fibre put acyl pentapeptide -3 shown in 2 referring to Fig.1, by SYN-COLL
(palm fibre puts acyl tripeptides -5；It 25ppm) is compared with commercialized competing product, (palm fibre puts acyl pentapeptide -3；It is 10ppm) brown in this test
Acyl pentapeptide -3 is put to seem even to deepen wrinkle, as seen from the figure, the production of the product of 2.5% rival of the SYN-COLL than 10%
Product cost is lower, and effect is more preferable.
Referring to Fig.1 shown in 3 one be experimental data, SYN-COLL stimulate hyaluronic acid synthesis and untreated cell
Compared to the case where it is as shown in the figure.
SYN-COLL stimulates the synthesis of hyaluronic acid, and hyaluronic acid is as shown in the human skin fibroblasts addition on upper layer
What Concentration X Substance culture measured after 72 hours.
It is the in vivo efficacy of SYN-COLL shown in 4 referring to Fig.1, stimulates the synthesis of hyaluronic acid in old fibroblast,
It is represented with 7 and shows young cell, represented with 28 and show aged cells, SYN-COLL 50um descendant's chrotoplast is added or do not added in measurement
The concentration of hyaluronic acid in fibroblast, the right picture indicate to show label of the sweet enzyme dyeing of β galactolipin as senile cell.
It is the in vivo efficacy of SYN-COLL shown in 5 referring to Fig.1, indicates that fibroblast (stretches) under mechanical stress, machine
The schematic diagram that tool load causes many cell signals and cell behavior to change, 1 in figure that represent is interleukins B,
In figure 2 indicate be interleukin 8, in figure 3 indicate TNF-α；Tensile cell culture, under the influence of SYN-COLL, allusion quotation
The change perceived of type proinflammatory cytokine, under mechanical stress, SYN-COLL inhibit proinflammatory cytokine such as TNF-α, IL-8:
TGFbeta、SYN-COLL。
The present invention also provides a kind of preparation methods for preparing the anti-ageing reparation double-layer bi-color essence comprising with
Lower step:
Component A is mixed evenly step 1) in proportion, for use；
Step 2) mixes component B in proportion, is stirred and heated to 80-85 DEG C；
Step 3) is cooled to 70 DEG C, and the component C heats 70-75 DEG C of dissolution in advance；It is equal that component C stirring is added in stirring on one side
Even, it is transparent that component D need to shift to an earlier date dispersing and dissolving, and then stirring on one side is added D component and cools down after mixing evenly；
After step 4) is cooled to 40 DEG C, it is transparent that component F component need to shift to an earlier date dispersing and dissolving, and component E, F is added and stirs evenly i.e.
It can；
Wherein, include in A raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, β-Hu
Radish element, jojoba seed oil, camellia seed oil, oat kernel oil；
Include in B raw material: allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride；
Include in C raw material: parahydroxyacet-ophenone, propylene glycol；
Include in D raw material: arginine；
Include in E raw material: avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5,
Lin Lan profit dew, septuple anti-sensitizer, 1,2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400；
Include in F raw material: water-soluble hesperidin.
Wherein, the ratio of the component A and component B/C/D/E/F mixed phase: 0.3:1.7.The essence prepared
Appearance: faint yellow bilayer essence, pH (25 DEG C): 6.50.
Claims (10)
1. a kind of anti-ageing reparation double-layer bi-color essence, which is characterized in that be made by following raw material: five polydimethylsiloxanes of ring
Alkane/cyclohexasiloxane, dimethyl silicone polymer, beta carotene, jojoba seed oil, camellia seed oil, oat kernel oil, allantoin,
EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride, parahydroxyacet-ophenone, propylene glycol, arginine, avenabeta glucosan, widow
Peptide -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan profit dew, septuple anti-sensitizer, 1,2 hexylene glycols, PEG-12
Glycerol monolaurate, polyethylene glycol-400, water-soluble hesperidin and deionized water.
2. anti-ageing reparation double-layer bi-color essence according to claim 1, which is characterized in that its can be divided into A, B, C, D, E,
Six kinds of mixed raw material compositions of F, each mixed raw material is mixed step by step and prepares the essence:
Wherein, include in A raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, β-carrot
Element, jojoba seed oil, camellia seed oil, oat kernel oil；
Include in B raw material: allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride；
Include in C raw material: parahydroxyacet-ophenone, propylene glycol；
Include in D raw material: arginine；
Include in E raw material: avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan
Profit dew, septuple anti-sensitizer, 1,2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400；
Include in F raw material: water-soluble hesperidin.
3. anti-ageing reparation double-layer bi-color essence according to claim 1, which is characterized in that the proportion of each raw material
(mass percent) are as follows:
4. anti-ageing reparation double-layer bi-color essence according to claim 3, which is characterized in that the proportion of each raw material
(mass percent) are as follows:
5. a kind of prepare the anti-ageing preparation method for repairing double-layer bi-color essence as described in claim 1, it is characterised in that packet
Include following steps:
Component A is mixed evenly step 1) in proportion, for use；
Step 2) mixes component B in proportion, is stirred and heated to 80-85 DEG C；
Step 3) is cooled to 70 DEG C, and stirring is added component C and stirs evenly on one side, and then stirring on one side is added D component and stirs evenly
After cool down；
After step 4) is cooled to 40 DEG C, component E, F is added and stirs evenly；
Wherein, include in A raw material: ring five dimethyl silicone polymer/cyclohexasiloxane, dimethyl silicone polymer, β-carrot
Element, jojoba seed oil, camellia seed oil, oat kernel oil；
Include in B raw material: allantoin, EDTA-2NA, glycerol, propylene glycol, glycine betaine, sodium chloride；
Include in C raw material: parahydroxyacet-ophenone, propylene glycol；
Include in D raw material: arginine；
Include in E raw material: avenabeta glucosan, oligopeptides -1, dendrobium candidum stem extraction, glycerol, palmityl tripeptides -5, Lin Lan
Profit dew, septuple anti-sensitizer, 1,2 hexylene glycols, PEG-12 glycerol monolaurate, polyethylene glycol-400；
Include in F raw material: water-soluble hesperidin.
6. the anti-ageing preparation method for repairing double-layer bi-color essence according to claim 5, it is characterised in that: in step 3)
In, the component C heats 70-75 DEG C of dissolution in advance；It is transparent that component D need to shift to an earlier date dispersing and dissolving.
7. the anti-ageing preparation method for repairing double-layer bi-color essence according to claim 5, it is characterised in that: in step 4)
In, it is transparent that component F component need to shift to an earlier date dispersing and dissolving.
8. the anti-ageing preparation method for repairing double-layer bi-color essence according to claim 5, it is characterised in that: the component
The ratio of A and component B/C/D/E/F mixed phase: 0.3:1.7.
9. the anti-ageing preparation method for repairing double-layer bi-color essence according to claim 5, it is characterised in that: each original
The proportion (mass percent) of material are as follows:
10. the anti-ageing preparation method for repairing double-layer bi-color essence according to claim 5, it is characterised in that: the essence
The pH value of Hua Su is 6.5.
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| CN111973464A (en) * | 2020-09-04 | 2020-11-24 | 广州市轩颜化妆品有限公司 | Double-layer wrinkle-removing and wrinkle-comforting shaking cream for face and preparation method thereof |
| CN114259420A (en) * | 2021-12-29 | 2022-04-01 | 青岛黛优佳生物科技有限公司 | Cosmetic composition and preparation method thereof |
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Application publication date: 20191025 |