CN103860449A - Skin care product with effect of removing stretch marks and preparation method thereof - Google Patents
Skin care product with effect of removing stretch marks and preparation method thereof Download PDFInfo
- Publication number
- CN103860449A CN103860449A CN201410098925.4A CN201410098925A CN103860449A CN 103860449 A CN103860449 A CN 103860449A CN 201410098925 A CN201410098925 A CN 201410098925A CN 103860449 A CN103860449 A CN 103860449A
- Authority
- CN
- China
- Prior art keywords
- skin care
- skin
- growth factor
- rhizoma
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010040925 Skin striae Diseases 0.000 title claims abstract description 42
- 230000000694 effects Effects 0.000 title claims abstract description 38
- 208000031439 Striae Distensae Diseases 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 22
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 18
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 14
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 13
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 13
- 239000011718 vitamin C Substances 0.000 claims abstract description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 12
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims abstract description 12
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 12
- 235000008434 ginseng Nutrition 0.000 claims abstract description 12
- 229940116978 human epidermal growth factor Drugs 0.000 claims abstract description 12
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 12
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims abstract description 12
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 11
- 229960000458 allantoin Drugs 0.000 claims abstract description 11
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000628997 Flos Species 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 18
- 230000003187 abdominal effect Effects 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 14
- DDKGKOOLFLYZDL-UHFFFAOYSA-N 3',4',7-trihydroxyisoflavone Chemical compound C=1C(O)=CC=C(C2=O)C=1OC=C2C1=CC=C(O)C(O)=C1 DDKGKOOLFLYZDL-UHFFFAOYSA-N 0.000 claims description 12
- 241000756943 Codonopsis Species 0.000 claims description 12
- 241001523405 Limax Species 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 12
- 241000208340 Araliaceae Species 0.000 claims description 11
- 230000006798 recombination Effects 0.000 claims description 11
- 238000005215 recombination Methods 0.000 claims description 11
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000002481 ethanol extraction Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 235000013599 spices Nutrition 0.000 claims description 5
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 abstract description 17
- 108010035532 Collagen Proteins 0.000 abstract description 17
- 102000016942 Elastin Human genes 0.000 abstract description 12
- 108010014258 Elastin Proteins 0.000 abstract description 12
- 229920002549 elastin Polymers 0.000 abstract description 12
- 229920001436 collagen Polymers 0.000 abstract description 8
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 230000004663 cell proliferation Effects 0.000 abstract description 6
- 210000002950 fibroblast Anatomy 0.000 abstract description 5
- 230000007803 itching Effects 0.000 abstract description 4
- 210000001519 tissue Anatomy 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 3
- 235000013372 meat Nutrition 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 2
- 230000001976 improved effect Effects 0.000 abstract description 2
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 244000144725 Amygdalus communis Species 0.000 abstract 1
- 235000011437 Amygdalus communis Nutrition 0.000 abstract 1
- 244000144730 Amygdalus persica Species 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 241000007126 Codonopsis pilosula Species 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 241000237858 Gastropoda Species 0.000 abstract 1
- 241000208680 Hamamelis mollis Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 239000008168 almond oil Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003833 cell viability Effects 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 108700005467 recombinant KCB-1 Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 229940118846 witch hazel Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 53
- 210000004027 cell Anatomy 0.000 description 24
- 239000003921 oil Substances 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- 210000002615 epidermis Anatomy 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 210000000130 stem cell Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 3
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 229960002591 hydroxyproline Drugs 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 230000036560 skin regeneration Effects 0.000 description 3
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 3
- 241000555712 Forsythia Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241000257303 Hymenoptera Species 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 2
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229960002429 proline Drugs 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 208000006770 Ascorbic Acid Deficiency Diseases 0.000 description 1
- MQVRGDZCYDEQML-UHFFFAOYSA-N Astragalin Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 MQVRGDZCYDEQML-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 102000018386 EGF Family of Proteins Human genes 0.000 description 1
- 108010066486 EGF Family of Proteins Proteins 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- YPWHZCPMOQGCDQ-UHFFFAOYSA-N Populnin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=CC(O)=CC=3)OC2=C1 YPWHZCPMOQGCDQ-UHFFFAOYSA-N 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- ZKEKDTIKFVCKMW-UHFFFAOYSA-N Trifolin Natural products OCC1OC(Oc2cc(O)ccc2C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O ZKEKDTIKFVCKMW-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000008294 cold cream Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- JPUKWEQWGBDDQB-DTGCRPNFSA-N kaempferol 3-O-beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O JPUKWEQWGBDDQB-DTGCRPNFSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a skin care product with an effect of removing stretch marks and a preparation method thereof. The skin care product consists of nidus vespae, fructus forsythiae, red flower, peach blossom, ginseng, gastrodia elata, dragon bone, red halloysite, witch hazel, coptis chinensis, codonopsis pilosula, bletilla striata, snail meat, a recombinant human epidermal growth factor, a recombinant human basic fibroblast growth factor, vitamin C, hyaluronic acid, sweet almond oil, rosehip seed oil, 1,3-butanediol, allantoin and auxiliary materials. The skin care product is a comprehensive and complete system and infiltrates into skin tissues through the synergistic effect between the traditional Chinese medicine and multiple nutrients, so that the fibroblast genes are activated, the cell viability is enhanced, and cell proliferation is promoted. Moreover, repair and synthesis of collagens and elastins are promoted, the skin resilience and elasticity are improved, and the skin care product has the effects of diminishing inflammation, relieving itching and reducing pigments, so that the aim of removing the stretch marks is achieved.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to skin care of pregrant abdominal stretch marks-removing effect and preparation method thereof.
Background technology
Anemia of pregnant woman later stage of pregnancy, uterus also can little by little increase along with the growth of fetus; When under the situation of abdominal part in rapid expanding, exceed the elongation of belly skin, will cause collagen fabric and elastin laminin that subcutaneous tissue is rich in to rupture because being unable to undergo expansion, produce striae gravidarum.Because abdominal part is at pregnancy duration, the ratio maximum of expansion, therefore, the forming part of striae gravidarum, maximum with abdominal part, at other positions, as around breast, femoribus internus, and buttocks also may occur, these positions are because tissue expander degree is larger, and cause striae gravidarum.Its distribution is often radiated outward by the mediad of health, become parallel shape or radial, and color is darker than other position of skin.Medically, striae gravidarum is called as dilatancy striped, it appears on anemia of pregnant woman's body in fact incessantly, some not conceived women are because its acth secretion goes out a kind of glucocorticoid, or because of reasons such as fat-reducing or long-term taking sugar sebum steroid hormones, abdominal part also there will be the skin pattern of similar striae gravidarum, these striae gravidarum bring endless worry to many Mies, the especially Ms that likes to be beautiful, and investigation shows, the appearance of striae gravidarum has caused being discord of conjugal relation, and the confidence and the family that have had a strong impact on the women that likes to be beautiful are stable.
More and more paid attention to for repairing striae gravidarum, had the investigative technique for striae gravidarum.Patent application document-striae gravidarum dermis restoration liquid of application number 201110342731.0, adopts Chinese medicine, accelerates division, the Growth and Reproduction differentiation of skin corium, stromal cell; The structure of skin comprises epidermis and corium, and this Chinese medicine is just repaired corium, and not to epidermal area reparation, and concrete curative effect there is no record.The cold cream of patent application document-elimination striae gravidarum of application number 201310391728.7, adopt breaking cellular wall meat poisoning rhzomorph, as everyone knows, meat poisoning rhzomorph is to health harmful substance, if improper use, to make a big impact to health, and expensive, in this technology, comprised collagen protein, and collagen protein is macromole, can not enter in cell by skin barrier, can not utilized by cell.The patent document of Granted publication CN 101152138 B, the main material synergism such as somatomedin, micromolecule polypeptide that adopt, promote fibroblast proliferation, synthetic more collagen protein, fibroblast is present in the skin corium of cell, this technology has just promoted the cell proliferation of skin corium, do not reach the effect of the cell proliferation that promotes epidermal area, the generation of striae gravidarum is except there being the fracture of collagen protein in addition, elastin laminin also ruptures simultaneously, and the reparation of striae gravidarum need to be promoted the synthetic of collagen protein and elastin laminin and be repaired.At present in some technology, technology emphasis is replenishing collagen how, and elastin laminin is even more important in fact.Elastin laminin is played the part of the role of rubber band in skin, allows skin have the ability of stretching, extension, and its function, just as the spring in mattress, is responsible for maintaining and the elasticity that supports skin.Therefore, dispel striae gravidarum and need to supplement reparation elastin laminin.Current technology does not all solve the sense of discomfort of itching that striae gravidarum brings to women in addition, and does not solve the different problem of striae gravidarum and normal skin color.
Summary of the invention
The object of this invention is to provide and a kind ofly realize the skin care of dispelling striae gravidarum by the mutual synergism of the many kinds of substance such as Chinese herbal medicine, recombinant human epidermal growth factor.
Another object of the present invention is to provide the preparation method of the above-mentioned skin care with pregrant abdominal stretch marks-removing effect.
The object of the invention is to be achieved through the following technical solutions:
A kind of skin care with pregrant abdominal stretch marks-removing effect, it is characterized in that comprising the raw material of following weight portion: Nidus Vespae 10-30 part, Fructus Forsythiae 20-30 part, Flos Carthami 3-9 part, Flos persicae 15-35 part, Radix Ginseng 5-15 part, Rhizoma Gastrodiae 8-12 part, Os Draconis 5-20 part, Halloysitum Rubrum 10-18 part, Radix Hamamelidis Mollis 30-45 part, Rhizoma Coptidis 30-40 part, Radix Codonopsis 25-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-60 part, Carnis Limax 10-50 part, recombinant human epidermal growth factor 1-5 part, recombination human basic fibroblast growth factor 1-4 part, vitamin C 1-10 part, hyaluronic acid 2-10 part, Semen pruni armeniacae oil 20-60 part, Rosehips oil 30-80 part, 1, 3-butanediol 3-9 part, allantoin 4-8 part, adjuvant 10-20 part.
An above-mentioned skin care, characterized by further comprising the raw material of following weight portion: 3', 4', 7-trihydroxy-isoflavone 1-5 part.
Prepare above-mentioned skin care, it is characterized in that described adjuvant is selected from thickening agent, antiseptic, PH regulator, dispersant, astringent, spice.
The method of the skin care with pregrant abdominal stretch marks-removing effect described in preparation, is characterized in that comprising the following steps:
1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, take, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: the 80% ethanol extraction 1-2 hour that adds for the first time crude drug 5-6 doubly to measure, filter, obtain filtrate; The water heating extraction 1-3 hour that adds for the second time crude drug 4-5 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) concentrated solution of step 1 is added to Semen pruni armeniacae oil, Rosehips oil, heated and stirred is cooled to 40～50 ℃ after dissolving completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, vitamin C, hyaluronic acid, 1,3-butanediol, allantoin, adjuvant, mix homogeneously, sterilizing, subpackage, sealing.
Preparation comprises 3', 4', the method of the skin care of 7-trihydroxy-isoflavone, it is characterized in that comprising the following steps, 1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, take, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: the 80% ethanol extraction 1-2 hour that adds for the first time crude drug 5-6 doubly to measure, filter, obtain filtrate; The water heating extraction 1-3 hour that adds for the second time crude drug 4-5 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) concentrated solution of step 1 is added to Semen pruni armeniacae oil, Rosehips oil, heated and stirred is cooled to 40～50 ℃ after dissolving completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, vitamin C, hyaluronic acid, 3', 4', 7-trihydroxy-isoflavone, 1,3-butanediol, allantoin, adjuvant, mix homogeneously, sterilizing, subpackage, sealing.
Principle of the present invention is:
Flos Carthami of the present invention has elimination effect to superoxide radical, can be for the aging resistance of skin; And the Flos Carthami effect of invigorating blood circulation, can promote the supply of blood, increase the activity of cell.
Flos persicae sweet in the mouth, pungent, slightly warm in nature, enters the heart, lung, large intestine channel, the effects such as the happy skin of invigorating blood circulation, drastic purgation diuresis, blood-activating analgetic; Modern medicine study shows, Flos persicae has good beautification function.The beautification function of Flos persicae, mainly to come from spending to contain the nutrient substance such as kaempferol, perfume (or spice), bean essence, trifolin and vitamin A, B, C, these substance blood vessel dilating, promotion of blood circulation, moist skin, improves blood circulation, promotes skin-nourishing and oxygen supply, make to promote the lipofuscin element of human senility to accelerate excretion, prevent melanin chronic deposition in skin.
Radix Codonopsis, Radix Ginseng are rich in aminoacid, are easily absorbed by the skin, and to preventing and treating xerosis cutis, coarse and wrinkle etc. effectively, also can strengthen the resistance against diseases of skin, thereby prevent and treat dermatosis, seborrheic dermatitis, suppurative dermatitis, vitamin C deficiency etc., of great advantage to skin.Radix Codonopsis and Flos persicae compatibility, can promote the generation of collagen protein and elastin laminin.
In the Pseudobulbus Bletillae (Rhizoma Bletillae), contain the raw materials such as abundant starch, glucose, volatile oil and phlegmatic temperament, can restraint of tyrosinase activity, therefore can whitening and speckle dispelling, astringing to arrest bleeding, detumescence and promoting granulation.
Rhizoma Gastrodiae energy suppressing the hyperactive liver QI invigorating, sharp waist knee joint, bone and muscle strengthening, also can increase periphery and coronary flow.
Nidus Vespae has antiinflammatory, itching-relieving action, and the senses of discomfort such as pain of itching that striae gravidarum brings to women are alleviated in Nidus Vespae and the combined effect of Pseudobulbus Bletillae (Rhizoma Bletillae) energy.
Radix Hamamelidis Mollis includes tannin matter and multiplely can regulate sebum secretion, have moisturizing and Milk Protein.Promote lymph blood circulation, the effect of have calmness, pacifying, is improved effect to skin
In Limax containing chondroitin sulfate native element, can metabolism aging cutin, prevent skin ageing, promote skin regeneration, prevent the injury of some harmful bacteria, promote the synthetic new life of fibroblast there is desalination cicatrix, skin sore, speckle and dwindles the functions such as pore.And Limax and Radix Hamamelidis Mollis, the compatibility of Rhizoma Gastrodiae can promote the generation of elastin laminin.
Chinese medicine of the present invention contains micromolecular polysaccharide, polypeptide, amino acids, have whitening skin and preserving moisture, releive crease-resistant, repair impaired cell, the effects such as the generation of promotion collagen protein and elastin laminin, antioxidation, restraint of tyrosinase activity, the features such as epidermis cell and hypodermal cell propagation that promote.
Recombinant human epidermal growth factor of the present invention, recombination human basic fibroblast growth factor participate in regulation and control cell generation cycle, promote cell proliferation, and the new and old replacement of cell is accelerated, and present young state.
3' of the present invention, 4', 7-trihydroxy-isoflavone can promote the propagation of epidermis cell, can utilize the known known method manufacture of the industry.The structure of skin comprises epidermis and corium, and epidermis can divide for the horny layer being made up of the hexagonal dead cell of plane and the epidermis of living.The epidermis of living comprises basal layer, has spinous layer, granular layer and 4 layers of clear layer.Wherein, skin keratin stem cell is positioned on basal layer, and skin keratin stem cell continues division will form transition amplifying cells.This type of cell carries out several division again, is formed on the horn cell of playing an important role in skin barrier function at the middle and late stage of skin production process.Horn cell breaks up, and rises into skin surface whereby in the later stage of skin production process.In this process, the differentiation of horn cell and keratinization are constantly to form cuticular source, and last, horn cell peels off out from horny layer.3', 4', 7-trihydroxy-isoflavone can be induced proliferating epidermal keratinocyte stem cells, has the effect that improves skin regeneration ability and improve skin elasticity.
Vitamin C of the present invention is the important cofactor of the synthetic middle hydroxylase of collagen process, the composition of collagen is glycine, proline, hydroxyproline or hydroxyproline, proline is in the time of synthetic hydroxyproline, need hydroxylase, vitamin C is its important cofactor, is therefore the synthetic requisite material of collagen.
Hyaluronic acid is that extracellular is unique does not have a Sulfated aminoglycan, has very strong water absorption, can adsorb the hydrone that is greater than own hundred times own, has very strong moisture retention.
Advantage of the present invention and good effect are:
Skin care of dispelling striae gravidarum provided by the present invention be one comprehensively, complete nutrition system, is the synergistic function of the various nutrients such as Chinese medicine and other chemical substances, infiltrate the tissue of skin, make fibroblast gene activation, increase cytoactive, impel cell proliferation; Goods of the present invention can promote the reparation of collagen protein and elastin laminin and synthesize, and improve the toughness of skin, recover skin vigor and elasticity.Thereby reach the object of dispelling striae gravidarum.
2. the present invention not only can promote the propagation of hypodermal cell, can also induce proliferating epidermal keratinocyte stem cells, has the effect that improves skin regeneration ability and improve skin elasticity; At present indivedual technology only relate to hypodermal cell, although and some technology have been used epithelical cell growth factor, only can promote epithelial cell, fibroblastic propagation; And 3' of the present invention, 4', 7-trihydroxy-isoflavone can be induced proliferating epidermal keratinocyte stem cells.
3. herbal mixture of the present invention has antiinflammatory, antipruritic effect simultaneously, except having solved the beauty treatment puzzlement of striae gravidarum except bringing to women, has also solved the discomfort of the pain of itching.
4. the invention provides the synthetic necessary vitamin C of collagen, promoted collagen synthetic, hyaluronic acid is also provided simultaneously, moistening environment is provided, make Skin tissue fluid full, is the prerequisite that cell is realized above-mentioned functions.
5. herbal mixture of the present invention also has the effect of restraint of tyrosinase simultaneously, and the desalination of striae gravidarum is played an important role, and the color of striae gravidarum and normal skin color are reached unanimity.
Skin care provided by the present invention be one comprehensively, complete nutrition system, many-sided propagation that promotes cell, promote cell proliferation from the transduction of cell signal, to the propagation of keratodermatitis and dermis of skin confluent monolayer cells, the present invention can not only promote the reparation of collagen protein with synthetic, can also promote the reparation of elastin laminin and synthesize, product of the present invention can be desalinated the color of skin, anti-inflammatory anti-itch, thus hyaluronic acid can make the moistening reparation striae gravidarum that reaches of cell simultaneously.
The specific embodiment
Embodiment 1
A kind of skin care with pregrant abdominal stretch marks-removing effect, it is characterized in that comprising the raw material of following weight portion: 10 parts of Nidus Vespaes, 20 parts of Fructus Forsythiaes, 3 parts, Flos Carthami, 15 parts, Flos persicae, 5 parts of Radix Ginsengs, 8 parts, Rhizoma Gastrodiae, 5 parts of Os Draconis, 10 parts of Halloysitum Rubrums, 30 parts of Radix Hamamelidis Molliss, 30 parts of Rhizoma Coptidis, 25 parts of Radix Codonopsis, 30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Carnis Limaxs, 1 part of recombinant human epidermal growth factor, 1 part of recombination human basic fibroblast growth factor, 1 part of vitamin C, 2 parts of hyaluronic acids, 20 parts of Semen pruni armeniacae oil, 30 parts of Rosehips oil, 1, 3 parts of 3-butanediols, 4 parts of allantoin, 10 parts of adjuvants.
The method of manufacturing the above-mentioned skin care with pregrant abdominal stretch marks-removing effect, comprises the following steps:
1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: 80% ethanol extraction 1 hour that adds for the first time 5 times of amounts of crude drug, filter, obtain filtrate; Add for the second time the water heating extraction 1-3 hour of 4 times of amounts of crude drug, filter, obtain filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) be cooled to 40 ℃ after the concentrated solution of step 1 being added Semen pruni armeniacae oil, Rosehips oil, heated and stirred dissolve completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, vitamin C, hyaluronic acid, 1,3-butanediol, allantoin, adjuvant mix homogeneously, sterilizing, subpackage, sealing.
Wherein said adjuvant is selected from thickening agent, antiseptic, PH regulator, dispersant, astringent, spice.
Embodiment 2
A kind of skin care with pregrant abdominal stretch marks-removing effect, it is characterized in that comprising the raw material of following weight portion: 30 parts of Nidus Vespaes, 30 parts of Fructus Forsythiaes, red 9 parts, 35 parts, Flos persicae, 15 parts of Radix Ginsengs, 12 parts, Rhizoma Gastrodiae, 20 parts of Os Draconis, 18 parts of Halloysitum Rubrums, 45 parts of Radix Hamamelidis Molliss, 40 parts of Rhizoma Coptidis, 50 parts of Radix Codonopsis, 60 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 50 parts of Carnis Limaxs, 5 parts of recombinant human epidermal growth factors, 4 parts of recombination human basic fibroblast growth factors, 3', 4', 5 parts of 7-trihydroxy-isoflavones, 10 parts of vitamin, 10 parts of hyaluronic acids, 60 parts of Semen pruni armeniacae oil, 80 parts of Rosehips oil, 1, 9 parts of 3-butanediols, 8 parts of allantoin, 20 parts of adjuvants.
The method of manufacturing the above-mentioned skin care with pregrant abdominal stretch marks-removing effect, comprises the following steps:
1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: the 80% ethanol extraction 1-2 hour that adds for the first time 6 times of amounts of crude drug, filter, obtain filtrate; Add for the second time the water heating extraction 3 hours that crude drug 4-5 doubly measures, filter, obtain filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) be cooled to 50 ℃ after the concentrated solution of step 1 being added Semen pruni armeniacae oil, Rosehips oil, heated and stirred dissolve completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, 3', 4', 7-trihydroxy-isoflavone, vitamin C, hyaluronic acid, 1,3-butanediol, allantoin, adjuvant mix homogeneously, sterilizing, subpackage, sealing.
Wherein said adjuvant is selected from thickening agent, antiseptic, PH regulator, dispersant, astringent, spice.
Implementation result: the skin care preparing is carried out to clinic trial observation.
The object of observation: choosing 24～38 years old age has women's 100 examples of striae gravidarum, is divided at random 2 groups, 50 every group, wherein first group uses the common skin care that there is no effect, and second group uses skin care of the present invention.
Using method: after cleaning skin, coat skin care at the position of striae gravidarum before sleep every night.Using continuously 28 days is a course for the treatment of, adheres to 3 months.
Experimental result:
| ? | Dispel striae gravidarum | Elasticity | Color | Smooth degree |
| First group | Without effect | Without effect | Without effect | Effect is general |
| Second group | Effect is very remarkable | Effect is very remarkable | Effect is more remarkable | Effect is very remarkable |
The above; only for the preferably specific embodiment of the present invention, but protection scope of the present invention is not limited to this, is anyly familiar with in technical scope that those skilled in the art disclose in the present invention; the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (5)
1. one kind has the skin care of pregrant abdominal stretch marks-removing effect, it is characterized in that comprising the raw material of following weight portion: Nidus Vespae 10-30 part, Fructus Forsythiae 20-30 part, Flos Carthami 3-9 part, Flos persicae 15-35 part, Radix Ginseng 5-15 part, Rhizoma Gastrodiae 8-12 part, Os Draconis 5-20 part, Halloysitum Rubrum 10-18 part, Radix Hamamelidis Mollis 30-45 part, Rhizoma Coptidis 30-40 part, Radix Codonopsis 25-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-60 part, Carnis Limax 10-50 part, recombinant human epidermal growth factor 1-5 part, recombination human basic fibroblast growth factor 1-4 part, vitamin C 1-10 part, hyaluronic acid 2-10 part, Semen pruni armeniacae oil 20-60 part, Rosehips oil 30-80 part, 1, 3-butanediol 3-9 part, allantoin 4-8 part, adjuvant 10-20 part.
2. a skin care according to claim 1, characterized by further comprising the raw material of following weight portion: 3', 4', 7-trihydroxy-isoflavone 1-5 part.
3. skin care according to claim 1 and 2, is characterized in that described adjuvant is selected from thickening agent, antiseptic, PH regulator, dispersant, astringent, spice.
4. prepare a method for the skin care with pregrant abdominal stretch marks-removing effect claimed in claim 1, it is characterized in that comprising the following steps:
1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, take, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: the 80% ethanol extraction 1-2 hour that adds for the first time crude drug 5-6 doubly to measure, filter, obtain filtrate; The water heating extraction 1-3 hour that adds for the second time crude drug 4-5 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) concentrated solution of step 1 is added to Semen pruni armeniacae oil, Rosehips oil, heated and stirred is cooled to 40～50 ℃ after dissolving completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, vitamin C, hyaluronic acid, 1,3-butanediol, allantoin, adjuvant, mix homogeneously, sterilizing, subpackage, sealing.
5. prepare a method for the skin care with pregrant abdominal stretch marks-removing effect claimed in claim 2, it is characterized in that comprising the following steps:
1) by Nidus Vespae, Fructus Forsythiae, Flos Carthami, Flos persicae, Radix Ginseng, Rhizoma Gastrodiae, Os Draconis, Halloysitum Rubrum, Radix Hamamelidis Mollis, Rhizoma Coptidis, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carnis Limax, take, be dried, pulverize and sieve by above-mentioned weight portion, extract twice: the 80% ethanol extraction 1-2 hour that adds for the first time crude drug 5-6 doubly to measure, filter, obtain filtrate; The water heating extraction 1-3 hour that adds for the second time crude drug 4-5 doubly to measure, filters, and obtains filtrate; Merge filtrate twice, filter, concentrated, obtain concentrated solution;
2) concentrated solution of step 1 is added to Semen pruni armeniacae oil, Rosehips oil, heated and stirred is cooled to 40～50 ℃ after dissolving completely, and then add successively recombinant human epidermal growth factor, recombination human basic fibroblast growth factor, vitamin C, hyaluronic acid, 3', 4', 7-trihydroxy-isoflavone, 1,3-butanediol, allantoin, adjuvant, mix homogeneously, sterilizing, subpackage, sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410098925.4A CN103860449B (en) | 2014-03-18 | 2014-03-18 | A kind of skin care with pregrant abdominal stretch marks-removing effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410098925.4A CN103860449B (en) | 2014-03-18 | 2014-03-18 | A kind of skin care with pregrant abdominal stretch marks-removing effect and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103860449A true CN103860449A (en) | 2014-06-18 |
| CN103860449B CN103860449B (en) | 2016-05-11 |
Family
ID=50899844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410098925.4A Active CN103860449B (en) | 2014-03-18 | 2014-03-18 | A kind of skin care with pregrant abdominal stretch marks-removing effect and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103860449B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906559A (en) * | 2015-06-30 | 2015-09-16 | 桂林华诺威基因药业有限公司 | Traditional Chinese medicine composition for treating burns and scalds |
| CN104921983A (en) * | 2015-05-25 | 2015-09-23 | 广西达庆生物科技有限公司 | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof |
| CN108057015A (en) * | 2018-01-12 | 2018-05-22 | 李忠 | A kind of striae of pregnancy repairs oil, preparation method and applications |
| CN108653158A (en) * | 2017-03-27 | 2018-10-16 | 上海莱妃化妆品有限公司 | There are the cosmetics and preparation method of auxiliary repair to sensitive skin |
| WO2019075801A1 (en) * | 2017-10-19 | 2019-04-25 | 广州无添加主义化妆品有限公司 | Skincare mask and preparation method therefor |
| CN113198003A (en) * | 2021-06-22 | 2021-08-03 | 万永年 | External liquid for preventing atrophic scars after skin injury and preparation method thereof |
| CN114344238A (en) * | 2022-02-15 | 2022-04-15 | 武汉中点医药科技有限公司 | Cosmetic product with effect of removing striae gravidarum and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083217A (en) * | 2011-11-03 | 2013-05-08 | 天津威欧斯生物科技发展有限公司 | Striae gravidarum epidermal repair liquid |
| CN103479565A (en) * | 2013-09-02 | 2014-01-01 | 吉安市御美丽健康产业有限公司 | Skin cream for removing striae gravidarum |
| CN103536519A (en) * | 2013-10-17 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Skin tendering cream for preventing striae gravidarum |
-
2014
- 2014-03-18 CN CN201410098925.4A patent/CN103860449B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083217A (en) * | 2011-11-03 | 2013-05-08 | 天津威欧斯生物科技发展有限公司 | Striae gravidarum epidermal repair liquid |
| CN103479565A (en) * | 2013-09-02 | 2014-01-01 | 吉安市御美丽健康产业有限公司 | Skin cream for removing striae gravidarum |
| CN103536519A (en) * | 2013-10-17 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Skin tendering cream for preventing striae gravidarum |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104921983A (en) * | 2015-05-25 | 2015-09-23 | 广西达庆生物科技有限公司 | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof |
| CN104906559A (en) * | 2015-06-30 | 2015-09-16 | 桂林华诺威基因药业有限公司 | Traditional Chinese medicine composition for treating burns and scalds |
| CN108653158A (en) * | 2017-03-27 | 2018-10-16 | 上海莱妃化妆品有限公司 | There are the cosmetics and preparation method of auxiliary repair to sensitive skin |
| WO2019075801A1 (en) * | 2017-10-19 | 2019-04-25 | 广州无添加主义化妆品有限公司 | Skincare mask and preparation method therefor |
| CN108057015A (en) * | 2018-01-12 | 2018-05-22 | 李忠 | A kind of striae of pregnancy repairs oil, preparation method and applications |
| CN113198003A (en) * | 2021-06-22 | 2021-08-03 | 万永年 | External liquid for preventing atrophic scars after skin injury and preparation method thereof |
| CN114344238A (en) * | 2022-02-15 | 2022-04-15 | 武汉中点医药科技有限公司 | Cosmetic product with effect of removing striae gravidarum and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103860449B (en) | 2016-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103860449B (en) | A kind of skin care with pregrant abdominal stretch marks-removing effect and preparation method thereof | |
| CN110692879A (en) | Collagen peptide drink and preparation method thereof | |
| KR100963792B1 (en) | Shampoo containing composite for growing hair and preventing fall-out of hair | |
| CN103585097B (en) | Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof | |
| CN101648003A (en) | Medicinal composition for treating gynecological inflammation and application thereof | |
| CN107157909A (en) | A kind of Hair-loss-preventingshampoo shampoo | |
| CN108686255A (en) | It is a kind of to prevent the biological dressing and preparation method thereof that scar is formed | |
| CN104921983A (en) | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof | |
| CN102657278A (en) | Asparagus healthcare tea | |
| CN102133168B (en) | Novel beautifying mask and preparation method thereof | |
| CN104434618A (en) | Nine-herb cream with effects of whitening and removing freckle marks and preparation method thereof | |
| CN102755613A (en) | Traditional Chinese medicine preparation for treating alopecia | |
| CN108743921A (en) | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed | |
| CN109464348A (en) | A kind of creme and preparation method thereof with beauty and improvement subhealth symptom | |
| CN110368347A (en) | Anti-ageing reparation double-layer bi-color essence of one kind and preparation method thereof | |
| KR100780180B1 (en) | Chinese composition preventing loss of hair and promoting growth of hair and method for preparing the same | |
| CN106362125A (en) | Health-care foot patch and application method thereof | |
| CN106036325A (en) | Fructus lycii enzyme and preparation method thereof | |
| CN105213279A (en) | A kind of body lotion eliminating striae atrophicae and preparation method thereof | |
| CN105380874A (en) | Preparation method of seaweed mask | |
| CN103875841B (en) | Tea drink with function of removing postpartum stretch marks, and preparation method thereof | |
| JP7365664B2 (en) | Dermal stem cell differentiation promoter | |
| CN102462655A (en) | Chinese medicinal herb anti-wrinkle paste and preparation method | |
| CN108635618B (en) | Preparation method of medical adhesive with healing promoting and repairing functions | |
| CN103040943A (en) | Chinese medicinal liniment for treating premature graying of youngsters |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Jian Inventor before: Yu Fazhou |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160412 Address after: Jinghu District of Anhui city of Wuhu province Jiuhua Road 241000 No. 263 Wuhu Second People's Hospital Applicant after: Li Jian Address before: 235000 Anhui Province Economic Development Zone Huaibei City Duji District Tengfei Road No. 7 Applicant before: Yu Fazhou |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160909 Address after: Jinghu District of Anhui city of Wuhu province Jiuhua Road 241000 No. 263 Wuhu Second People's Hospital Patentee after: WUHU NO.2 PEOPLE'S Hospital Address before: Jinghu District of Anhui city of Wuhu province Jiuhua Road 241000 No. 263 Wuhu Second People's Hospital Patentee before: Li Jian |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20180521 Address after: 050000 Shijiazhuang, Changan District, Hebei, 20 Heping Road, 20 Li new district - free port apartment Patentee after: Shijiazhuang Chi Hui Electronic Technology Co.,Ltd. Address before: 241000 Wuhu Second People's Hospital, 263 Jiuhua Road, Jinghu District, Wuhu, Anhui. Patentee before: WUHU NO.2 PEOPLE'S Hospital |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181029 Address after: 200000 Hongkou District, Shanghai Guangji road 173, 10 level 1001 room (centralized registration) Patentee after: Australia Lauder (Shanghai) Biotechnology Co.,Ltd. Address before: 050000 Shijiazhuang, Changan District, Hebei, 20 Heping Road, 20 Li new district - free port apartment Patentee before: Shijiazhuang Chi Hui Electronic Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190531 Address after: 510800 Room 1202, Building 179 Yingbin Avenue, Huadu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Miyanxiu Biotechnology Co.,Ltd. Address before: 200000 Hongkou District, Shanghai Guangji road 173, 10 level 1001 room (centralized registration) Patentee before: Australia Lauder (Shanghai) Biotechnology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510800 Room 1202, Building 179 Yingbin Avenue, Huadu District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU IYANXIU BIOLOGY TECHNOLOGY Co.,Ltd. Address before: 510800 Room 1202, Building 179 Yingbin Avenue, Huadu District, Guangzhou City, Guangdong Province Patentee before: Guangzhou Miyanxiu Biotechnology Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200323 Address after: 510800 Building 5, No.41, Lianglong South Street, Huashan Town, Huadu District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU YUANDA BIOTECHNOLOGY Co.,Ltd. Address before: 510800 Room 1202, Building 179 Yingbin Avenue, Huadu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU IYANXIU BIOLOGY TECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right |