CN114259420A - Cosmetic composition and preparation method thereof - Google Patents
Cosmetic composition and preparation method thereof Download PDFInfo
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- CN114259420A CN114259420A CN202111632195.8A CN202111632195A CN114259420A CN 114259420 A CN114259420 A CN 114259420A CN 202111632195 A CN202111632195 A CN 202111632195A CN 114259420 A CN114259420 A CN 114259420A
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Abstract
The invention belongs to the technical field of skin care product preparation, and discloses a cosmetic composition and a preparation method thereof. The cosmetic composition consists of a mixture of retinol, beta carotene and essential oil; 0.05 to 0.5 percent of retinol, 0.0025 to 0.05 percent of beta carotene and 94.5 to 99.475 percent of essential oil mixture according to the mass ratio. The cosmetic composition is prepared by preparing emulsion from jojoba oil, white chinlon oil and grapeseed oil, and cooling; cooling the emulsion, and adding retinol and beta carotene; and adding antioxidant and surfactant. The mixture of beta carotene and vitamin A provided by the invention can enhance the light stability and improve the utilization rate of active ingredients; the natural and safe raw materials are selected, so that the preservative can be effectively used, the safety of the product is improved, the irritation risk is reduced, and the effects of better antioxidation and anti-aging effects and skin color brightening can be achieved.
Description
Technical Field
The invention belongs to the technical field of skin care product preparation, and particularly relates to a cosmetic composition and a preparation method thereof.
Background
"skin" is used to refer to the entire skin of the human body, including the area of skin covered with body hair. Thus, in particular, facial skin, neckline skin, skin of arms and legs, lips and scalp are targeted.
Human skin is composed of three regions, namely a superficial region as epidermis, dermis, and a deep region as subcutaneous tissue. The epidermis is a keratinized, stratified squamous epithelium. It is composed mainly, i.e. of keratinocytes and other cells, and rests on the basement membrane separating it from the dermis.
The dermis is connective tissue. Its structure results from the arrangement and interaction between the components of the extracellular matrix and fibroblasts, which perform the synthesis and degradation of the dermis. The dermis constitutes the majority of the skin. The dermis is composed of collagen and elastic fibers, as well as mucopolysaccharides and proteoglycans. These different structures form complex networks which play an important role in the biomechanical properties of the skin.
The skin is constantly exposed to physical, chemical, mechanical or infectious external attacks, in particular generated by the climate, ultraviolet radiation, tobacco, pollution and or exogenous substances such as microorganisms. Skin is not able to recover from biological clock aging and light-induced or sun aging. These aging phenomena are manifested by their uneven pigmentation, pigmentation spots, dark yellow skin color, sagging, wrinkles, dryness, roughness, etc., through a series of characteristic clinical symptoms that occur upon prolonged exposure of the skin to light.
The expression "symptoms of skin ageing" is used to indicate all the alterations in the appearance of the skin due to ageing, whether chronobiological and or photoinduced or associated with the menopause, such as wrinkles and fine lines, wrinkled skin, loose skin, thinned skin, dull skin lacking radiance, lack of elasticity and or tension of the skin.
For obvious reasons, all of these changes or symptoms of skin aging are generally unacceptable to individuals for aesthetic reasons.
Retinol or retinol compounds are useful for skin aging, especially to reduce deep wrinkles and fine lines, skin laxity and hyperpigmentation.
Vitamin a is not a single compound, but a series of retinol derivatives including retinol (retinol), retinal (retinene), retinoic Acid (retinic Acid), retinol AcetAte (retinyl AcetAte), retinol palmitate (retinyl palmitate), and the like. Vitamin A is only present in animals, and is present in fish, especially cod liver oil, in large amounts. Plants do not contain vitamin a, but many vegetables and fruits contain provitamin-carotene, which is decomposed in the small intestine to vitamin a, wherein 1 molecule of beta-carotene can be decomposed to 2 molecules of vitamin a, whereas 1 molecule of a-carotene or gamma-carotene can only produce 1 molecule of vitamin a.
Since vitamin a acetate (retinol acetate) is more stable than vitamin a alcohol (retinol), the commercial product known as "vitamin a" on the market, which is actually vitamin a acetate, is a pale yellow oily liquid that is curable upon freezing, has little or weak fishy smell but no rancidity taste, is very soluble in chloroform or esters, is also soluble in anhydrous ethanol and vegetable oils, but is insoluble in glycerol and water, and is unstable in air and when exposed to light.
Retinol (retinol) is in the form of yellow flaky crystals or crystalline powder, is insoluble in water and glycerin, and is soluble in most organic solvents such as alcohols, ethers, hydrocarbons, and halogenated hydrocarbons. It is chemically stable, but is easily damaged by exposure to heat, light or air, and should generally be stored protected from light.
Vitamin A can be protected because vitamin A alcohol (retinol) has insufficient light stability, and carotene has color capable of reducing light transmission.
Through the above analysis, the problems and defects of the prior art are as follows:
(1) the prior art has no ideal wrinkle-removing effect on the anti-wrinkle and anti-aging products of the skin.
(2) The prior art vitamin A-containing acetate anti-skin wrinkle aging product is unstable when exposed to light and has short quality guarantee period, so that the cost of the anti-skin wrinkle aging product is increased.
(3) The prior art has lower utilization rate of active ingredients of the acetate product containing vitamin A and resisting skin wrinkle and aging.
(4) The safety effects of the prior acetate anti-skin wrinkle aging product containing vitamin A on the antisepsis, irritation risk, oxidation resistance and aging resistance need to be further improved.
The difficulty in solving the above problems and defects is: the product is unstable when exposed to light, has short shelf life and low utilization rate of active ingredients.
The significance of solving the problems and the defects is as follows: further improves the safety effect of oxidation resistance and aging resistance, improves the utilization rate of active ingredients of the product, and reduces the cost of customers on the product.
The invention provides a mixture of carotene and vitamin A (10% of carotene is added in the original vitamin A component), and the photostability analysis demonstration is carried out by measuring the absorption peak and the contents of vitamin A alcohol and carotene after 3 days of illumination.
Disclosure of Invention
To overcome the problems of the related art, the disclosed embodiments of the present invention provide a cosmetic composition, a method of preparing the same, and applications thereof.
The present invention aims to provide a true product containing a "retinol" (retinol) ingredient. The stability of vitamin A alcohol (retinol) added into the product is increased.
The technical scheme is as follows: a cosmetic composition consisting of a mixture of retinol, beta carotene and essential oil;
0.05 to 0.5 percent of retinol, 0.0025 to 0.05 percent of beta carotene and 94.5 to 99.475 percent of essential oil mixture according to the mass ratio.
In one embodiment, the essential oil mixture consists of jojoba oil, meadowfoam seed oil, grape seed oil, antioxidants, and surfactants;
the cosmetic composition consists of 50% of jojoba oil, 30% of chinaroot greenbrier seed oil, 19.48% of grape seed oil, 0.2% of antioxidant, 0.1% of surfactant, 0.2% of retinol and 0.02% of beta carotene according to mass ratio.
In one embodiment, the antioxidant is tocopherol; the surfactant is tween-20.
In one embodiment, the cosmetic composition consists of 0.1% of retinol, 0.003% of beta-carotene, and 98.97% of essential oil mixture by mass ratio.
In one embodiment, the cosmetic composition is composed of 0.3% of retinol, 0.03% of beta carotene, and 96.7% of essential oil mixture by mass ratio.
In one embodiment, the cosmetic composition is composed of 0.05% of retinol, 0.0025% of beta carotene, and 99.475% of essential oil mixture by mass ratio.
In one embodiment, the cosmetic composition consists of 0.5% of retinol, 0.05% of beta carotene, and 94.5% of essential oil mixture by mass ratio.
In one embodiment, the cosmetic composition has a pH of 4.5 to 8.0.
Another object of the present invention is to provide a method for preparing a cosmetic composition comprising:
preparing emulsion by using jojoba oil, chinaroot greenbrier seed oil and grape seed oil, and cooling;
step two, adding retinol and beta carotene after the emulsion is cooled;
and step three, adding an antioxidant and a surfactant.
In one embodiment, retinol is added after the emulsion is cooled to below 40 ℃ in step two.
By combining all the technical schemes, the invention has the advantages and positive effects that:
the carrot is a precursor of the vitamin A, and can be metabolized and converted into the vitamin A after being absorbed by the skin of a human body, so that the synergistic effect can be achieved. The present invention proposes a ratio. The wrinkle removing effect can be achieved by 0.1% alcohol A provided by Disemann.
The color of the carotene can reduce the light transmission, so the carotene has the protection effect on the vitamin A alcohol, and the invention carries out the light stability analysis demonstration on the contents of the vitamin A alcohol and the carotene by measuring the absorption peak and after X days of illumination.
The corresponding product of the invention can be added with oil products, such as essential oil, or water-in-oil cream products to obtain related skin care products.
The advantages of the present invention over the prior art further include: the mixture of carotene and vitamin A provided by the invention can enhance the light stability and improve the utilization rate of active ingredients; the natural and safe raw materials are selected, the preservative can be effectively used, so that the safety of the product is improved, the irritation risk is reduced, and the effects of better antioxidation and anti-aging effects and skin color brightening can be achieved.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present disclosure and together with the description, serve to explain the principles of the disclosure.
FIG. 1 is a flow chart of a method for preparing a cosmetic composition according to an embodiment of the present invention.
Fig. 2(a) is a graph showing the overall effect of protecting retinol from light damage according to the embodiment of the present invention.
Fig. 2(b) is a schematic representation of the benefits of retinol in attenuating fine lines and wrinkles and in enhancing skin firmness and elasticity provided by embodiments of the present invention.
FIG. 3 is a graph of the long-lasting anti-aging efficacy usage provided by embodiments of the present invention.
Fig. 4 is a graph illustrating the increase in mucopolysaccharide content of retinol-treated skin compared to placebo-treated skin, provided by an example of the present invention.
FIG. 5 is a graph showing the effects of retinol in promoting epidermal cell proliferation and thickening of the epidermis.
FIG. 6 is a graph showing the effect of retinol in promoting Ki67 protein expression.
Fig. 7 is a schematic diagram of the effect of retinol on improving skin smoothness and promoting epidermal cell proliferation, thereby promoting epidermal thickening.
FIG. 8 is a graph showing the inhibition of tyrosinase and tyrosinase-related proteins in B16 melanoma cells according to an embodiment of the present invention.
Fig. 9 is a schematic view of retinol in improving dark brown and mottled pigmentation, wherein fig. 9(a) is a schematic view of improvement of dark brown and mottled pigmentation; FIG. 9(b) is a graph showing the effect of remarkably improving the pigmentation phenomenon after 1 year of use.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed as broadly as the present invention is capable of modification in various respects, all without departing from the spirit and scope of the present invention.
The invention provides a cosmetic composition, which consists of a mixture of retinol, beta carotene and essential oil; wherein, the carotene: retinol is 1:10-1: 20;
0.05 to 0.5 percent of retinol, 0.0025 to 0.05 percent of beta carotene and 94.5 to 99.475 percent of essential oil mixture according to the mass ratio.
In a preferred embodiment, the essential oil mixture consists of jojoba oil, meadowfoam seed oil, grape seed oil, antioxidant and surfactant in a mass ratio.
In a preferred embodiment, the antioxidant is tocopherol; the surfactant is tween-20.
In a preferred embodiment, the pH value of the cosmetic composition is 4.5-8.0.
As shown in fig. 1, the present invention provides a method for preparing a cosmetic composition comprising:
s101, preparing emulsion by using jojoba oil, chinaroot greenbrier seed oil and grape seed oil, and cooling;
s102, adding retinol and beta carotene after the emulsion is cooled;
s103, adding an antioxidant and a surfactant.
In a preferred embodiment, retinol is added after the emulsion is cooled to below 40 ℃ in step S102.
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1
The cosmetic composition (vitamin A alcohol essential oil) provided by the embodiment of the invention comprises the following components in percentage by mass
Comparative example (No retinol and beta carotene added)
Plant essence oil (blank)
Example 2
The cosmetic composition provided by the embodiment of the invention comprises 0.1% of retinol, 0.003% of beta carotene and 98.97% of essential oil mixture in percentage by mass.
Example 3
The cosmetic composition consists of 0.3% of retinol, 0.03% of beta carotene and 96.7% of essential oil mixture according to the mass ratio.
Example 4
The cosmetic composition consists of 0.05% of retinol, 0.0025% of beta carotene and 99.475% of essential oil mixture according to the mass ratio.
Example 5
The cosmetic composition consists of 0.5 percent of retinol, 0.05 percent of beta carotene and 94.5 percent of essential oil mixture according to the mass ratio.
The technical solution of the present invention is further described below with reference to specific examples.
The invention provides a skin care product for promoting wrinkle removal, which consists of retinol and an antioxidant;
the pH value of the final formula is 4.5-8.0;
antioxidants such as tocopherol or BHT improve the stability of retinol.
The preparation method comprises the following steps:
retinol can be dissolved/mixed in oil and fat;
pure retinol addition amount: daily care, hand cream: 0.3 percent; a body care product: 0.05 percent;
retinol is temperature sensitive (>40 ℃), so when an emulsion is produced, it is added after emulsification and cooling to below 40 ℃; antioxidants such as tocopherol or BHT are added to improve the stability of retinol.
The technical solution of the present invention is further described below with reference to experimental analysis.
1. Retinol has the main effects:
retinol can lighten skin aging signs, promote skin cell proliferation, thicken epidermis and form stronger skin barrier function. Retinol also improves skin appearance and enhances skin elasticity.
Anti-aging; reducing photodamage to the skin, reducing fine lines and wrinkles, enhancing skin firmness and elasticity, improving skin smoothness, and reducing skin roughness.
2. Skin color:
retinol can relieve the phenomena of brown, dark yellow and mottled pigmentation, and can make skin color uniform.
Retinol also has anti-aging effects: retinol increases the content of type I collagen and elastin in the skin; retinol increases collagen synthesis; inducing the formation of dermal elastin and fibers in the skin.
Improving the structure of collagen and elastic fibers in the papillary dermis and improving the structure of the true epidermal junction.
3. Retinol improves overall photoaging:
retinol is one of the most effective skin care actives to improve skin photoaging, with significant efficacy in as little as one month.
The efficacy evaluation of retinol was performed in winter, 64 female volunteers aged 40-65 years, double-blind, half-face, blank control, random test, cycle 8 weeks.
Moisturizing creams containing 0.1% retinol were applied daily. Evaluation scores were scored by the dermatologist on 0-9 scales at the initial, week 4 and week 8, respectively. Such as the overall photodamage protection effect of retinol in figure 2(a), and the contribution of retinol in figure 2(b) to the reduction of fine lines and wrinkles and to the enhancement of skin firmness and elasticity.
4. Long lasting anti-aging efficacy: the use effect graph is shown in fig. 3.
After 1 year of using the retinol product, the aging signs can still be improved;
type I procollagen (blue staining of the dermoepidermal junction tissue) indicates new collagen synthesis in the skin.
5. Retinol skin protectant (CORNEOCARETM):
5.1 can promote the deposition of mucopolysaccharide in the epidermis;
5.2 topical retinol promotes the expression of mucopolysaccharide (hyaluronic acid) in chronically aging skin. After 24 weeks, the mucopolysaccharide content was increased by an average of 40% in the skin treated with retinol compared to the skin treated with the blank control. As shown in fig. 4.
The test also proves that the composition is still effective after 1 year of use! Topical retinol (0.1%) induced the expression of hyaluronic acid in the dermis and epidermis.
5.3 can promote the increase of the number of epidermal proliferation cells:
thinning of the epidermis in mature skin; epidermal thinning is a sign of aging due to a reduced rate of keratinocyte turnover; the epidermis under fine lines and wrinkles is especially thin; retinol promotes the proliferation of epidermal cells, thereby promoting the thickening of the epidermis. The effect graph is shown in fig. 5.
5.4 Retinol promotes an increase in the number of epidermal proliferating cells:
thinning of the epidermis in mature skin: epidermal thinning is a sign of aging due to a reduced rate of keratinocyte turnover. The epidermis under the fine lines and wrinkles is especially thin. Retinol promoted Ki67 protein expression as shown in FIG. 6.
5.5 Retinol can improve skin smoothness:
according to the record of 24 weeks, the rough skin touch after the treatment with retinol is obviously improved;
the epidermis underlying the fine lines and wrinkles is particularly thin. The retinol can promote the proliferation of epidermal cells, thereby promoting the thickening of the epidermis. As shown in fig. 7.
5.6 improving skin color: inhibiting the expression of tyrosinase.
Tyrosinase is a major enzyme in melanin synthesis, whereas α -MSH is a natural melanocyte-stimulating hormone, IBMX is a melanin synthesis stimulator.
Retinol inhibits the expression of tyrosinase and tyrosinase related proteins in B16 melanoma cells. As shown in fig. 8. Wherein, FIG. 8(a) is a graph of inhibition of tyrosinase expression in B16 melanoma cells; FIG. 8(B) is a graph showing the inhibition of tyrosinase-related protein expression in B16 melanoma cells.
5.7 improving skin color: retinol helps to ameliorate the phenomena of brownish yellow, dull and mottled pigmentation.
A double-blind half-face placebo randomized analysis over an 8-week period was performed in winter on 64 female volunteers between 40 and 65 years of age.
The efficacy of retinol was evaluated. Subjects used a moisturizer containing 0.1% retinol daily. Dermatologists performed clinical assessments of the semi-facial skin status at baseline, week 4 and week 8 according to a score scale of 0-9 points. As shown in fig. 9. Wherein FIG. 9(a) is a schematic representation of improvement of tan-dark and mottled pigmentation; FIG. 9(b) is a graph showing the effect of remarkably improving the pigmentation phenomenon after 1 year of use.
Experiments prove that the carotene (retinol) is added to enhance the stability of the vitamin A alcohol and finally play a role in removing wrinkles. The invention can develop different skin care products according to a plurality of proportion.
Other embodiments of the disclosure will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure disclosed herein. This application is intended to cover any variations, uses, or adaptations of the disclosure following, in general, the principles of the disclosure and including such departures from the present disclosure as come within known or customary practice within the art to which the disclosure pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the disclosure being indicated by the following claims.
It will be understood that the present disclosure is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The scope of the present disclosure should be limited only by the attached claims.
Claims (10)
1. A cosmetic composition consisting of a mixture of retinol, beta carotene and essential oil;
0.05 to 0.5 percent of retinol, 0.0025 to 0.05 percent of beta carotene and 94.5 to 99.475 percent of essential oil mixture according to the mass ratio.
2. The cosmetic composition of claim 1, wherein the essential oil mixture consists of jojoba oil, meadowfoam seed oil, grape seed oil, antioxidants, and surfactants;
the cosmetic composition consists of 50% of jojoba oil, 30% of chinaroot greenbrier seed oil, 19.48% of grape seed oil, 0.2% of antioxidant, 0.1% of surfactant, 0.2% of retinol and 0.02% of beta carotene according to mass ratio.
3. The cosmetic composition of claim 2, wherein the antioxidant is tocopherol; the surfactant is tween-20.
4. The cosmetic composition according to claim 1, characterized in that it consists of retinol 0.1%, beta-carotene 0.003% and essential oil mixture 98.97% in mass ratio.
5. The cosmetic composition according to claim 1, characterized in that it consists of retinol 0.3%, beta-carotene 0.03% and essential oil mixture 96.7% in mass ratio.
6. The cosmetic composition according to claim 1, wherein the cosmetic composition consists of 0.05% by mass of retinol, 0.0025% by mass of beta-carotene, and 99.475% by mass of essential oil mixture.
7. The cosmetic composition according to claim 1, characterized in that it consists of retinol 0.5%, beta-carotene 0.05% and essential oil mixture 94.5% in mass ratio.
8. Cosmetic composition according to claim 1, characterized in that the cosmetic composition has a pH value: 4.5 to 8.0.
9. A method for preparing a cosmetic composition according to any one of claims 1 to 8, characterized in that it comprises:
preparing emulsion by using jojoba oil, chinaroot greenbrier seed oil and grape seed oil, and cooling;
step two, adding retinol and beta carotene after the emulsion is cooled;
and step three, adding an antioxidant and a surfactant.
10. A process for the preparation of a cosmetic composition according to claim 9 wherein in step two the retinol is added after the emulsion has cooled to below 40 ℃.
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| CN111329772A (en) * | 2020-04-16 | 2020-06-26 | 齐振乾 | Skin-brightening and freckle-removing lotion and preparation method thereof |
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2021
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|---|---|---|---|---|
| JPH09110669A (en) * | 1985-12-11 | 1997-04-28 | Lvmh Rech | Composition for skin disease or for cosmetics |
| JP2002265313A (en) * | 2001-03-06 | 2002-09-18 | Kose Corp | Skin care preparation |
| KR20100060753A (en) * | 2008-11-28 | 2010-06-07 | (주)아모레퍼시픽 | Anti-aging cosmetic composition |
| US20130309183A1 (en) * | 2012-05-18 | 2013-11-21 | Le Thuy Vuong | Skin anti-oxidant enhancing formulation and associated method |
| US20190307662A1 (en) * | 2018-04-06 | 2019-10-10 | Pangaea Laboratories Limited | Compositions and methods for stabilization of retinoids |
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