CN112315845A

CN112315845A - Whitening and freckle removing cream and preparation method thereof

Info

Publication number: CN112315845A
Application number: CN202011404962.5A
Authority: CN
Inventors: 邱镇国; 张毅; 梁达锋; 李怡殊
Original assignee: Guangdong Gadetin Daily Necessities Co ltd
Current assignee: Guangdong Gadetin Daily Necessities Co ltd
Priority date: 2020-12-03
Filing date: 2020-12-03
Publication date: 2021-02-05

Abstract

The invention relates to the field of cosmetics, and particularly relates to a whitening and freckle-removing cream and a preparation method thereof. The raw materials for preparing the whitening and freckle-removing cream at least comprise a low-temperature phase component, a water phase component and an oil phase component; the low temperature phase component comprises a skin tone improving composition, acid pea seed polysaccharide, betaine; the composition for improving skin color comprises a skin toner and a plant extract. The whitening cream has the effects of substantially moisturizing, moistening, whitening, removing freckles and resisting allergy, and has the advantages of higher formula mildness, stable product, more obvious whitening effect and no stimulation. Inhibiting the activity of tyrosinase, inhibiting the oxidation reaction in the process of melanogenesis, inhibiting the expression and transfer of melanogenesis-related protein, and synergistically inhibiting the formation of melanosis and color spots in multiple aspects.

Description

Whitening and freckle removing cream and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to a whitening and freckle-removing cream and a preparation method thereof.

Background

Whitening is always sought by asian women, and with the improvement of the living standard and aesthetic standard of people, smooth, fair, and even skin with little speckles or pigment deposition is more and more advocated. The skin color becomes dark due to a plurality of factors such as natural aging and the like, and people can achieve the effect by applying whitening products such as whitening milk, whitening cream, whitening essence and the like. Wherein the whitening agent generally comprises ascorbic acid and its derivatives, arbutin, glabridin, etc. The whitening effect is achieved mainly by inhibiting the enzymatic activity related to the synthesis of eumelanin such as tyrosinase, inhibiting the transfer of melanin from the basal layer to the epidermal layer, and promoting the production of melatonin to inhibit the production of eumelanin.

At present, in order to lighten stains, wrinkles and skin color, the skin can be whitened only by cosmetics and concealer products, but the skin is only covered, and the surface is good but not treated. In addition, the existing whitening and freckle-removing cream can only focus on solving a certain problem, but cannot give consideration to various effects, for example, comprehensive problems in various aspects such as moisturizing, moistening, whitening, freckle removing, anti-allergy, repairing and the like are also given consideration to, and even if the existing commercially available product is declared to be capable of solving the problems in various aspects, the advertised effect is difficult to achieve really and practically. The skin care products sold on the market are various, but the existing whitening products are added with too many synthetic chemical reagents and are easy to damage the skin. Particularly, a great amount of mercury and hydroquinone-containing preparations are added into part of whitening and freckle-removing cosmetics, which can rapidly achieve the effects of whitening and removing freckles, but the accumulation of toxic substances can cause facial skin necrosis of consumers, and incurable green spots or white spots are left. At present, hydroquinone has good whitening effect but has toxicity and carcinogenicity to a human body, so the hydroquinone is forbidden to be used in a resident product; arbutin has good whitening effect, but is easy to generate hydroquinone under certain conditions; ascorbic acid is unstable, easily oxidized in neutral or alkaline solutions, unstable under light and heat conditions, and easily yellowed after storage for a certain period of time, so many ascorbic acid derivatives such as ascorbic acid phosphate, ascorbic acid glucoside, and ascorbic acid ethyl ether appear.

Therefore, a whitening and freckle-removing cream with substantial moisturizing, moistening, whitening, freckle removing and anti-allergy functions is needed, has high tolerance to functional substances in the cream, is stable in formula, can achieve whitening, skin tendering, anti-allergy and other effects, keeps the facial skin young, and does not damage the skin after long-term use.

Disclosure of Invention

In order to solve the above problems, the first aspect of the present invention provides a whitening and spot-removing cream, which is prepared from at least a low-temperature phase component, a water phase component, and an oil phase component; the low temperature phase component comprises a composition for improving skin color, acid soybean seed polysaccharide, betaine; the composition for improving skin color comprises a skin toner and a plant extract.

As a preferred technical scheme, the complexion improving agent is selected from one or more of niacinamide, tranexamic acid, glabridin, a yeast cell lysis fermentation product and a rice fermentation product filtrate.

As a preferred technical scheme, the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the schizolysis fermentation product of the yeast and the rice fermentation product filtrate is (2.5-3.5): (1.5-2.5): (0.08-0.12): (0.05-0.15): (0.8-1.2).

As a preferred technical scheme, the plant extract is selected from one or more of magnolia sieboldii extract, mulberry root extract, undaria pinnatifida extract and hypsizygus marmoreus callus culture filtrate.

As a preferable technical scheme, the mass ratio of the magnolia sieboldii extract to the mulberry root extract to the undaria pinnatifida extract is (0.05-0.15): (0.05-0.15): 0.01.

as a preferred technical scheme, the low-temperature phase component also comprises sodium metabisulfite; the mass ratio of the skin toner, the plant extract, the tamarind seed polysaccharide, the betaine and the sodium metabisulfite is (5.5-7.0): (0.2-0.3): (0.1-0.3): (0.4-0.6): (0.04-0.06).

As a preferable technical scheme, the water phase component comprises, by weight, 3-6 parts of glycerol, 0.8-1.2 parts of butanediol, 0.15-0.25 part of allantoin, 0.01 part of sodium hyaluronate and 60-70 parts of water.

As a preferable technical scheme, the oil phase component comprises 1.5-2.5 parts of glyceryl stearate and PEG-100 stearate, 0.8-1.2 parts of cetearyl olive oleate and sorbitan olive oleate, 3-5 parts of cetearyl alcohol, 2-4 parts of palmitoyl ethylhexyl ester, 2-4 parts of caprylic/capric triglyceride, 0.4-0.6 part of tocopherol acetate, 1.5-2.5 parts of glycerol triethyl hexanoate, 2-4 parts of polydimethylsiloxane and 0.04-0.06 part of bisabolol in parts by weight.

As a preferable technical scheme, the preparation raw materials of the whitening and freckle-removing cream also comprise a component C and a component D; the component C comprises 0.02-0.04 part by weight of triethanolamine and 0.7-1.2 parts by weight of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The second aspect of the invention provides a preparation method of the whitening and freckle-removing cream, which comprises the following steps:

s1: weighing the water phase components into an emulsifying pot, heating, stirring and homogenizing to obtain a mixture 1;

s2: weighing the oil phase components into an oil phase pot, heating and stirring to obtain a mixture 2;

s3: adding the mixture 2 into the mixture 1, homogenizing and emulsifying uniformly, stirring and cooling to obtain a mixture 3;

s4: adding the component C into the mixture 3, stirring and homogenizing, and continuously cooling to obtain a mixture 4;

s5: mixing and dissolving the component D, putting the component D into the mixture 4, and stirring and mixing to obtain a mixture 5;

s6: and sequentially adding the low-temperature phase components into the mixture 5, and stirring and mixing to obtain the whitening and freckle-removing cream.

Has the advantages that: the whitening and freckle-removing cream provided by the invention has the effects of substantially moisturizing, moistening, whitening, freckle removing, anti-allergy and repairing, adopts tranexamic acid and nicotinamide as whitening and freckle-removing components, inhibits the activity of tyrosinase, inhibits the oxidation reaction in the melanogenesis process, inhibits the expression and transfer of melanogenesis-related protein, and synergistically inhibits the formation of melanin and color spots in multiple aspects. By improving scientific compounding among skin color agents, the whitening effect is more obvious, the formula is higher in mildness, the product is stable, and the whitening and freckle removing essence has the characteristics of stable system, long acting, moisture retention and the like while effectively achieving the whitening and freckle removing effects.

Detailed Description

The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when the range "1 to 5" is disclosed, the described range should be construed as including the ranges "1 to 4", "1 to 3", "1 to 2", "2 to 3" and "3 to 4", "4 to 5" and "3 to 5", etc. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

In order to solve the technical problems, the invention provides a whitening and freckle-removing cream which is prepared from at least a low-temperature phase component, a water phase component and an oil phase component.

In one embodiment, the mass ratio of the low-temperature phase component to the water phase component to the oil phase component is (5-12): (63.96-77.46): (13.24-23.86); preferably, the mass ratio of the low-temperature phase component to the water phase component to the oil phase component is 7.16: 70.66: 18.55.

low temperature phase component

In one embodiment, the low temperature phase components include a composition for improving skin tone, tamarind seed polysaccharides, betaines; the composition for improving skin color comprises a skin toner and a plant extract.

(toner for improving skin conditions)

In one embodiment, the skin tone improving agent is selected from one or more of niacinamide, tranexamic acid, glabridin, schizosaccharomyces cerevisiae lysate fermentation product, rice fermentation product filtrate; preferably, the skin toner is a mixture of niacinamide, tranexamic acid and glabridin.

In a preferred embodiment, the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the cracked yeast cell lysis fermentation product and the rice fermentation product filtrate is (2.5-3.5): (1.5-2.5): (0.08-0.12): (0.05-0.15): (0.8-1.2); more preferably, the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the cracked yeast cell lysis fermentation product and the rice fermentation product filtrate is 3: 2: 0.1: 0.1: 1.

in the present invention, nicotinamide (niacinamide), also called nicotinamide, is an amide compound of nicotinic acid. A crystalline powder that is white; no or almost no odorSmelly and bitter; it is slightly hygroscopic. It is easily soluble in water or ethanol, and soluble in glycerol. Chemical formula C₆H₆N₂O, molecular weight 122.13, CAS number 98-92-0.

In one embodiment, the nicotinamide is purchased from cypress chemical company, ltd.

In the invention, the Tranexamic acid is also named tranoxamic acid (Tranexamic acid) and Tranexamic acid, the chemical name of the Tranexamic acid is trans-4-aminomethyl cyclohexanecarboxylic acid, and white crystalline powder is prepared; no smell, slightly bitter taste. Is easily soluble in water and hardly soluble in ethanol, acetone, chloroform or diethyl ether. Molecular formula C₈H₁₅NO₂CAS number 1197-18-8, molecular weight 157.21 at 1 standard atmosphere, density 1.095g/cm³The melting point was 233 ℃ and the boiling point was 300.2 ℃.

In one embodiment, the tranexamic acid is purchased from Shanghai Violet Pont biomedical corporation, Inc.

The tranexamic acid and the nicotinamide are used as whitening and freckle-removing components, the activity of the tyrosinase is inhibited, the oxidation reaction in the melanogenesis process is inhibited, the expression and transfer of melanogenesis-related protein are inhibited, and the formation of the melanogenesis and the freckles is inhibited in a multi-aspect synergistic manner. Particularly, the glabridin and the nicotinamide have a compound synergistic effect, and the whitening effect is more obvious when the glabridin and the nicotinamide are matched together.

In the invention, the glabridin is a flavonoid substance and is extracted from a precious plant called glabrous licorice, and the glabridin is known as whitening gold because of the strong whitening effect, can eliminate free radicals and muscle bottom melanin and is a whitening and anti-aging holy substance for skin. The molecular formula is as follows: c₂₀H₂₀O₄CAS number: 59870-68-7. It has strong anti-free radical oxidation effect in cytochrome P450/NADPH oxidation system, and can obviously inhibit free radicals generated in vivo metabolism process, so as to prevent biomacromolecule (low density lipoprotein LDL, DNA) sensitive to oxidation and cell wall and the like from being damaged by free radical oxidation. Thereby preventing and treating certain pathological changes related to free radical oxidation, such as atherosclerosis, cell aging and the like. In addition, glabridin has definite therapeutic effectHas effects in reducing blood lipid and lowering blood pressure.

In one embodiment, the glabridin is purchased from oxsnow chemical, inc.

In the present invention, the lysate of the fermentation product of the binary split yeast is a chemical substance, and the CAS number is 96507-89-0. Is prepared from Bifidobacterium through culturing, deactivating and decomposing to obtain metabolite, cytoplasm segment, cell wall component and polysaccharide complex. The lysate of the yeast fermentation product has strong anti-immunosuppression activity, can promote DNA repair, can effectively protect skin from being damaged by ultraviolet rays, is used for skin care, sun protection and after-sun care products of emulsion, water-based and hydroalcoholic systems, and helps to prevent photoaging of epidermis and dermis. The yeast fermentation product lysate can generate small molecules which comprise vitamin B group, minerals, amino acids and the like and are beneficial to skin care, and the yeast essence is high-quality yeast essence only used for skin care. It has effects in promoting metabolism of stratum corneum, capturing free radicals, inhibiting lipid peroxidation, whitening skin, and resisting aging. The product is rich in nutrients, and has skin nourishing effect.

In one embodiment, the split yeast fermentation product lysate is purchased from cypress chemical company, ltd.

In the invention, the rice fermentation product filtrate is a natural rice bran fermentation product, has the whitening effect, and can inhibit the growth of melanin and the activation of the tyrosinase. But the generation of cholesterol and ceramide is promoted, the cholesterol and the ceramide are important components of sebum, and the increase of the content of the cholesterol and the ceramide is helpful for improving the skin softness, so the cholesterol and the ceramide have the conditioning effect; has effects of activating glutathione reductase, improving skin activity and resisting aging.

In one embodiment, the rice fermentation product filtrate is of the brand number

XGN, purchased from New chemical industries, Inc.

(plant extract)

In one embodiment, the plant extract is selected from one or more of magnolia sieboldii extract, mulberry root extract, undaria pinnatifida extract, hypsizygus marmoreus callus culture filtrate; preferably, the skin color improving extract is a mixture of magnolia sieboldii extract, mulberry root extract and undaria pinnatifida extract.

In a preferred embodiment, the mass ratio of the magnolia sieboldii extract to the mulberry root extract to the undaria pinnatifida extract is (0.05-0.15): (0.05-0.15): 0.01; more preferably, the mass ratio of the magnolia sieboldii extract to the mulberry root extract to the undaria pinnatifida extract is 0.1: 0.1: 0.01.

in the invention, the magnolia sieboldii extract is extracted from flowers and branches of magnolia sieboldii, is a component with a whitening effect, and can be used as a skin conditioner.

In one embodiment, the magnolia sieboldii extract is purchased from baihabo corporation.

In the invention, the mulberry root extract contains a plurality of effective substances such as mulberroside and the like, can powerfully take out free radicals, inhibit tyrosinase activity, inhibit indirect melanin formation, effectively relieve pressure and keep a pleasant mood.

In one embodiment, the mulberry root extract is purchased from clariant corporation.

The undaria pinnatifida extract is a pure natural surfactant, has excellent oxidation resistance, antibacterial property, anti-inflammatory property and dispersing capacity, and is used as a skin conditioner and a skin protective agent.

In one embodiment, the undaria pinnatifida extract is purchased from oxsnow chemical ltd, guangzhou.

(tamarind seed polysaccharide)

In the invention, the sour soybean seed polysaccharide has the following components: sour bean polysaccharide and tamarind seed polysaccharide can be used as thickener, and has effects of slightly increasing viscosity, stabilizing emulsion, keeping moisture better than hyaluronic acid, reducing skin roughness, increasing skin elasticity, and providing velvet skin feeling.

In one embodiment, the tamarind seed polysaccharide is purchased from shanghai ascend daycare technologies, inc.

(betaine)

In the invention, the betaine is an alkaloid, the chemical name of the betaine is 1-carboxyl-N, N, N-trimethyl glycine lactone, the chemical structure of the betaine is similar to that of amino acid, the betaine belongs to a quaternary ammonium base substance, and the molecular formula of the betaine is C₅H₁₁NO₂. The raw powder was fluid and was a slightly brown powder. The melting point is 293 ℃. Is very soluble in water and methanol.

In one embodiment, the betaine is purchased from cypress chemical company, ltd.

The addition of betaine can improve the moisturizing effect and stability of the composition for improving skin color.

In one embodiment, the low temperature phase component further comprises sodium metabisulfite.

(sodium metabisulfite)

In the invention, the sodium metabisulfite has a chemical formula of Na₂S₂O₅CAS registry No. 7681-57-4, is an inorganic compound, white or yellow crystals, with strong pungent odor, dissolved in water, the aqueous solution is acidic, and when contacting with strong acid, sulfur dioxide is released and corresponding salts are formed. When the sodium pyrosulfite is put in the air for a long time, sodium sulfate is oxidized, so the sodium pyrosulfite cannot be stored for a long time.

In one embodiment, the mass ratio of the skin toner, the plant extract, the tamarind seed polysaccharide, the betaine and the sodium metabisulfite is (5.5-7.0): (0.2-0.3): (0.1-0.3): (0.4-0.6): (0.04-0.06); preferably, the mass ratio of the skin toner, the plant extract, the tamarind seed polysaccharide, the betaine and the sodium metabisulfite is 6.2: 0.21: 0.2: 0.5: 0.05.

according to the invention, betaine, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate, tamarind seed polysaccharide, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate, magnolia sieboldii extract, mulberry root extract and undaria pinnatifida extract are added into low-temperature phase components, so that the skin melanin content can be further reduced, the skin whitening and skin melanin lightening effects can be achieved, the skin whitening effect can be kept for a long time in nicotinamide, tranexamic acid and glabridin, more importantly, the stability of the whitening and freckle removing cream is improved, the skin whitening and freckle removing cream does not have a layering phenomenon after being placed at 48 ℃ for 30 days, the skin whitening and skin melanin removing cream does not have a solidification phenomenon after being placed at-18 ℃ for 30 days, and the skin does not turn yellow after being stored for a long time.

Aqueous phase component

In one embodiment, the water phase component comprises 3-6 parts by weight of glycerin, 0.8-1.2 parts by weight of butanediol, 0.15-0.25 parts by weight of allantoin, 0.01 parts by weight of sodium hyaluronate, and 60-70 parts by weight of water; preferably, the water phase component comprises 5 parts of glycerol, 1 part of butanediol, 0.2 part of allantoin, 0.01 part of sodium hyaluronate and 65 parts of water in parts by weight.

(Glycerol)

In the invention, the glycerin is colorless, transparent, odorless and viscous liquid, tastes sweet and has hygroscopicity. Mixing with water and alcohols, amines and phenols in any ratio, and making the aqueous solution neutral.

(butanediol)

In the invention, the butanediol is 1, 2-butanediol and can be used as a cosmetic moisturizer and a solvent, and the CAS number: 26171-83-5.

(allantoin)

In the invention, the allantoin, namely N- (2, 5-dioxo-4-imidazolinyl) urea has a molecular formula of C₄H₆N₄O₃Is a hydantoin derivative. The pure allantoin is a non-toxic, tasteless, non-irritant and non-allergenic white crystal, and is crystallized in water into a prism or colorless crystalline powder. Can be dissolved in hot water, hot alcohol and dilute sodium hydroxide solution. Water and alcohol which are slightly soluble at normal temperature are difficult to dissolve in organic solvents such as ether and chloroform; the saturated aqueous solution (concentration is 0.6%) is slightly acidic; the pH was 5.5. Is stable in aqueous solution with pH value of 4-9. Is also stable in non-aqueous solvents and dry air; can be decomposed by boiling in strong alkaline solution and exposing in sunlight.

CAS number 97-59-6, structural formula:

(sodium hyaluronate)

In the invention, the sodium hyaluronate has the chemical formula of (C)₁₄H₂₀NO₁₁Na) n, an inherent component in human body, is a glucan aldehyde acid, has no species specificity, and is widely present in tissues such as placenta, amniotic fluid, crystalline lens, articular cartilage, skin dermis and the like; it is distributed in the cytoplasm and the intercellular substance of the organ, and plays a role in lubricating and nourishing the cells and the organelles contained therein. Sodium hyaluronate belongs to high molecular polymer and has strong lubricating feeling and film forming property. The skin care product containing sodium hyaluronate has obvious lubrication feeling and good hand feeling when being smeared. After being applied to the skin, a layer of film can be formed on the surface of the skin, so that the skin can generate good smooth feeling and moist feeling, and the protective effect on the skin is achieved.

In one embodiment, the sodium hyaluronate is available under the trade designation Hybloom sodium hyaluronate (HA-T) and purchased from Huaxi Biotech.

(Water)

In the invention, the water is deionized water.

Oil phase component

In one embodiment, the oil phase components include, by weight parts, 1.5-2.5 parts of glyceryl stearate and PEG-100 stearate, 0.8-1.2 parts of cetearyl and sorbitan olivil oleate, 3-5 parts of cetearyl alcohol, 2-4 parts of ethylhexyl palmitoyl, 2-4 parts of caprylic/capric triglyceride, 0.4-0.6 part of tocopheryl acetate, 1.5-2.5 parts of glyceryl triethylhexanoate, 2-4 parts of polydimethylsiloxane, 0.04-0.06 part of bisabolol; preferably, the oil phase components comprise, by weight, 2 parts of glyceryl stearate and PEG-100 stearate, 1 part of cetearyl olivetoleate and sorbitan olivetoleate, 4 parts of cetearyl alcohol, 3 parts of ethylhexyl palmitat, 3 parts of caprylic/capric triglyceride, 0.5 part of tocopherol acetate, 2 parts of glyceryl triethylhexanoate, 3 parts of polydimethylsiloxane, and 0.05 part of bisabolol.

(Glycerol stearate and PEG-100 stearate)

In the present invention, the glyceryl stearate and PEG-100 stearate are available under the trade name ARLACEL170-PA- (SG) from Daco company

The invention adopts glyceryl stearate and PEG-100 stearate as oil-in-water emulsifier suitable for various lipophilic substances, which is stable in specific cosmetic acidic environment, can be used in combination with various surface active ingredients, can be used as a clearing agent in products, is an oil-in-water emulsifier suitable for various lipophilic substances, is stable in specific cosmetic acidic environment, can be used in combination with various surface active ingredients, and can be used as a clearing agent in products.

(cetearyl olive oleate and sorbitan olive oleate)

In the present invention, the cetearyl olive oleate and sorbitan olive oleate are available from Holothan corporation in Olivem 1000.

Olivem1000 is a new generation mild skin-friendly emulsifier derived from natural vegetable olive oil, does not contain EO, can form a self-emulsifying system, can form a liquid crystal structure, is easy to spread, and obtains a refreshing, silky and invar hand feeling and has long-acting moisture retention; excellent skin affinity and easy absorption, because olive oil is the oil with the highest affinity with the skin among all natural oils. The natural waxy oil can introduce active ingredients into skin, and the unique network structure can contain a large amount of oil, prevent the oil from being oxidized, has excellent moisture retention capacity and can enhance the elasticity and smoothness of the skin.

(cetostearyl alcohol)

In the present invention, CETEARYL ALCOHOL, herein designated CETEARYL ALCOHOL, has the formula C₁₆H₃₄O, white solid crystal, particle or wax block shape and has fragrance. Insoluble in water, soluble in ethanol, diethyl ether, chloroform and mineral oil. The catalyst and concentrated sulfuric acid have sulfonation reaction and do not have chemical action when meeting strong alkali. Has the effects of inhibiting greasy feeling, reducing viscosity of wax raw materials, and stabilizing cosmetic emulsion.

In one embodiment, the cetearyl alcohol is purchased from New Enhan chemical commerce, Foshan.

(ethylhexyl palmitoyl)

In the invention, the palmitoyl ethylhexyl ester, (2-EHP), named as isooctyl hexadecanoate, octyl palmitate, 2-ethylhexyl palmitate and 2-ethylhexyl palmitate, is clear and transparent liquid, is tasteless, insoluble in water, is compatible with most solvents, is a high-purity high-grade fatty acid ester product, is mainly used as a cosmetic raw material, and is an excellent skin softening agent. Has stable property, and is not easy to oxidize or generate peculiar smell. The skin can be soft, tender and smooth without greasy feeling, has good permeability, is fresh and cool, is easy to push away, has no sticky feeling of common vegetable oil, is easy to permeate into pores to clean grease dirt due to small molecules, but also can permeate into keratinocytes, and can cause the skin to be keratinized and become coarse and yellow when being used excessively. The dosage is 1 to 5 percent, and the mixture is added into the oil phase. Is suitable for oily raw materials of various cosmetics, but is not suitable for aqueous products. Chemical formula C₂₄H₄₈O₂CAS number 29806-73-3.

(caprylic/capric triglyceride)

In the invention, the caprylic/capric triglyceride is high-cleanness odorless grease, and belongs to derivatives of palm oil or coconut oil. Can be used as base material of moisturizing factor, cosmetic stabilizer, antifreezing agent, and homogenizing agent. Is easy to be absorbed by skin, and has good effect on the uniformity and fineness of cosmetics, so that the skin is smooth and glossy. Has characteristics compatible with human skin, is suitable for oily skin, does not block pores, has non-greasy texture, can improve extensibility by being added into cream or lotion, has effects of lubricating and softening skin, and has the function of filtering ultraviolet light.

In one embodiment, the caprylic/capric triglyceride is purchased from oxsnow.

(Tocopherol acetate)

In the invention, the tocopherol acetate is easily soluble in chloroform, diethyl ether, acetone and vegetable oil, is soluble in alcohol and is insoluble in water. Has good heat resistance, can be oxidized when being exposed to light, has dark color and belongs to vitamin E derivatives.

In one embodiment, the tocopherol acetate is purchased from beijing beiLeililai daily chemical Co.

The tocopherol acetate belongs to a derivative of vitamin E, is commonly used as an antioxidant in cosmetics, has good antioxidant effect, is an oil-soluble natural substance, is a good nutritional moistening agent for skin, can prevent rancidity oxidation of oil and stabilize the oil when added into a care product. The composition has good effects in moisturizing and maintaining connective tissues, and protecting skin from ultraviolet rays, and can soften skin touch and retain skin moisture, promote wound healing, prevent inflammation, prevent skin from rough and chapped, improve black spots, and has a low safety risk index, thus being widely used. The tocopherol acetate is used as an antioxidant in the oil phase, so that the high-temperature stability of the system is improved.

(Glycerol triethylhexanoate)

In the invention, the glycerol triethyl caproate is liquid oil, colorless, transparent, tasteless and odorless; a multifunctional oil agent having a very excellent quality by high purification. CAS number 7360-38-5, excellent low temperature performance, high branching degree, excellent spreadability and air permeability, and is a very light, fast and dry emollient. The cosmetic has low freezing point, excellent freezing resistance, excellent compatibility and no stimulation to skin, and can improve the freezing resistance of cosmetics.

(polydimethylsiloxane)

In the invention, the polydimethylsiloxane is a hydrophobic organic silicon material. CAS registry No. 9006-65-9, tradename DC200/100SCT, purchased from Dow Corning Inc.

(bisabolol)

In the invention, the bisabolol is a component existing in the chamomile, and the anti-inflammatory effect of the chamomile is mainly derived from the bisabolol. Bisabolol is colorless to glutinous liquid of rice straw yellow, and is soluble in lower alcohol (ethanol, isopropanol), fatty alcohol, glyceride and vinegar, and hardly soluble in water and glycerol.

In one embodiment, the bisabolol is α -bisabolol.

In the present invention, the α -bisabolol has a chemical formula C₁₅H₂₆O, CAS number 515-69-5, structural formula:

the invention adopts alpha-bisabolol as a skin feel regulator, has good stability and excellent skin compatibility, and not only has anti-inflammatory performance, but also is proved to have bacteriostatic activity.

In one embodiment, the raw materials for preparing the whitening and freckle-removing cream further comprise a component C and a component D.

In one embodiment, the mass ratio of the low-temperature phase component, the water phase component, the oil phase component, the C component and the D component is (5-12): (63.96-77.46): (13.24-23.86): (0.72-1.24): (2.9-4.5); preferably, the mass ratio of the low-temperature phase component, the water phase component, the oil phase component, the C component and the D component is 7.16: 70.66: 18.55: 0.93: 2.7.

c component

In one embodiment, the C component comprises 0.02 to 0.04 part of triethanolamine, 0.7 to 1.2 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer; preferably, the component C comprises 0.03 part of triethanolamine and 0.9 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer in parts by weight.

(Triethanolamine)

In the present invention, the triethanolamine, i.e., tris (2-hydroxyethyl) amine, is an organic compound that can be regarded as a trihydroxy substituent of triethylamine and has a chemical formula of C₆H₁₅NO₃. Similar to other amine compounds, because of the lone pair of electrons on the nitrogen atom, triethanolamine has weak alkalinity and can react with inorganic acid or organic acid to generate salt. CAS number 102-71-6.

(hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer)

In the invention, the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is a solid anionic acrylic polymer, has high dissolution speed in water (can be prepared into paste at room temperature), and is used for thickening an aqueous solution and maintaining the stability of an O/W emulsion. The product is a quick thickening agent and has emulsifying capacity. And the thickener has good adaptability to the conditions of lower or higher pH value, certain electrolyte tolerance capability, shear dilution provided by the thickener and good compatibility. CAS number 111286-86-3, purchased from Baihabo corporation.

D component

In one embodiment, the D component comprises 0.5 to 0.7 part of 1, 2-pentanediol, 0.5 to 0.7 part of 1, 2-hexanediol, 1.5 to 2.5 parts of 1, 2-butanediol and 0.4 to 0.6 part of p-hydroxyacetophenone by weight parts; preferably, the component D comprises 0.6 part of 1, 2-pentanediol, 0.6 part of 1, 2-hexanediol, 2 parts of 1, 2-butanediol and 0.5 part of p-hydroxyacetophenone in parts by weight.

(1, 2-pentanediol)

In the invention, the 1, 2-pentanediol has a chemical formula of C₅H₁₂O₂Can be dissolved in organic solvents such as alcohol, ether and ethyl acetate, and is often applied to cosmetic solvents. CAS number 5343-92-0.

(1, 2-hexanediol)

In the present invention, the 1, 2-hexanediol has a molecular formula C₆H₁₄O₂And a molecular weight of 118.17. A colorless transparent liquid. Has mild sweet flavor. Dissolving in water, ethanol, ether, and low-carbon aliphatic hydrocarbon. Can be used as solvent, perfume, and medical disinfectant. Acetone is condensed to obtain diacetone alcohol, and the diacetone alcohol is subjected to liquid phase hydrogenation to obtain the product. CAS number: 107-41-5.

(1, 2-butanediol)

In the present invention, the 1, 2-butanediol can be used as a cosmetic moisturizer and solvent, CAS No.: 26171-83-5.

(p-hydroxyacetophenone)

In the invention, the p-hydroxyacetophenone is white needle-shaped crystal at normal temperature, is combustible, is easily soluble in hot water, methanol, ethanol, diethyl ether, acetone and benzene, and is difficult to dissolve in petroleum ether. CAS registry number 99-93-4, molecular formula C₈H₈O₂。

The 1, 2-butanediol, 1, 2-pentanediol and 1, 2-hexanediol are compounded to be synergistic, and simultaneously, the solvent has good solubility to p-hydroxyacetophenone, and the 1, 2-butanediol has the moisturizing effect and acts together with the p-hydroxyacetophenone, so that the irritation of the system is reduced.

In one embodiment, the preparation method of the whitening and freckle-removing cream comprises the following steps:

s1: weighing the water phase components into an emulsifying pot, heating to 80-85 ℃, and stirring and homogenizing to obtain a mixture 1;

s2: weighing oil phase components into an oil phase pot, heating to 80-85 ℃, and stirring to obtain a mixture 2;

s3: adding the mixture 2 into the mixture 1, homogenizing and emulsifying uniformly, stirring and cooling to 55-65 ℃ to obtain a mixture 3;

s4: adding the component C into the mixture 3, stirring and homogenizing, and continuously cooling to 40-45 ℃ to obtain a mixture 4;

s5: mixing and completely dissolving the component D at about 60 ℃, adding the component D into the mixture 4, and stirring and mixing to obtain a mixture 5;

The whitening and freckle-removing cream prepared by the method can improve the stability of the whitening and freckle-removing cream, is not layered or discolored, can obviously reduce the content of skin melanin, and has the effects of whitening and fading the skin melanin. The skin color becomes white and obvious.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Examples

Example 1

Embodiment 1 provides a whitening and freckle-removing cream, which is prepared from the following raw materials: a low-temperature phase component, a water phase component, an oil phase component, a C component and a D component; the mass ratio of the low-temperature phase component to the water phase component to the oil phase component to the C component to the D component is 6.03: 77.11: 13.24: 0.72: 2.9;

the low-temperature phase component comprises a skin toner improving agent, a plant extract, acid soybean seed polysaccharide, betaine and sodium metabisulfite; the mass ratio of the skin toner improving agent to the plant extract to the tamarind seed polysaccharide to the betaine to the sodium metabisulfite is 5.18: 0.21: 0.2: 0.4: 0.04; the skin color improving agent is a mixture of nicotinamide, tranexamic acid, glabridin, a lysis fermentation product of saccharomyces cerevisiae and a filtrate of a rice fermentation product; the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the schizolysis fermentation product of the yeast and the rice fermentation product filtrate is 2.5: 1.5: 0.08: 0.1: 1; the nicotinamide CAS number 98-92-0; the tranexamic acid CAS number 1197-18-8; the glabridin CAS number is 59870-68-7; the tamarind seed polysaccharide is purchased from Shanghai ascend daycare technologies, Inc.; the two split yeast fermentation product lysate purchased from cypress chemical company; the rice fermentation product filtrate has the brand number of

XGN, purchased from New chemical industries, Inc.; the plant extract is Magnolia sieboldiiA mixture of the extract, mulberry root extract, undaria pinnatifida extract; the mass ratio of the magnolia sieboldii extract to the mulberry root extract to the undaria pinnatifida extract is 0.1: 0.1: 0.01; the Magnolia sieboldii extract was purchased from Baihabo corporation; the mulberry root extract is purchased from clariant corporation; the Undaria pinnatifida extract is purchased from Auxue chemical Co., Ltd, Guangzhou; the betaine is purchased from cypress chemical company, ltd; the CAS accession number of sodium metabisulfite is 7681-57-4;

the water phase components comprise 3 parts of glycerin, 0.8 part of butanediol, 0.15 part of allantoin, 0.01 part of sodium hyaluronate and 73.15 parts of water in parts by weight; the allantoin CAS number 97-59-6; the sodium hyaluronate is Hybloom sodium hyaluronate (HA-T) and purchased from Huaxi Biotech company;

the oil phase components comprise 1.5 parts of glyceryl stearate and PEG-100 stearate, 0.8 part of cetearyl olive oleate and sorbitan olive oleate, 3 parts of cetearyl alcohol, 2 parts of palmitoyl ethylhexyl ester, 2 parts of caprylic/capric triglyceride, 0.4 part of tocopherol acetate, 1.5 parts of glyceryl triethylhexanoate, 2 parts of polydimethylsiloxane and 0.04 part of bisabolol in parts by weight; the glyceryl stearate and PEG-100 stearate were purchased from prochloraz; cetearyl olive oleate and sorbitan olive oleate, model Olivem1000, available from Holothan corporation; the cetearyl alcohol was purchased from Xinan chemical trade, Inc. of Foshan; the palmitoyl ethylhexyl ester CAS number 29806-73-3; the caprylic/capric triglyceride was purchased from oxsnow; the tocopherol acetate was purchased from Beijing Beiliei daily chemical Co., Ltd; the glycerol triethylhexanoate CAS number 7360-38-5; the polydimethylsiloxane, having a designation of DC200/100SCT, was purchased from Dow Corning; the bisabolol is alpha-bisabolol with CAS number 515-69-5;

the component C comprises 0.02 part of triethanolamine and 0.7 part of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer in parts by weight; the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer CAS number 111286-86-3, purchased from Baihaobo corporation;

the component D comprises 0.5 part of 1, 2-pentanediol, 0.5 part of 1, 2-hexanediol, 1.5 parts of 1, 2-butanediol and 0.4 part of p-hydroxyacetophenone in parts by weight.

The preparation method of the whitening and freckle-removing cream comprises the following steps:

s1: weighing the water phase components into an emulsifying pot, heating to 83 ℃, and stirring and homogenizing to obtain a mixture 1;

s2: weighing oil phase components into an oil phase pot, heating to 83 ℃, and stirring to obtain a mixture 2;

s3: adding the mixture 2 into the mixture 1, homogenizing and emulsifying uniformly, stirring and cooling to 60 ℃ to obtain a mixture 3;

s4: adding the component C into the mixture 3, stirring and homogenizing, and continuously cooling to 45 ℃ to obtain a mixture 4;

s5: mixing and dissolving the component D at 60 ℃, putting the component D into the mixture 4, and stirring and mixing to obtain a mixture 5;

Example 2

Embodiment 2 provides a whitening and freckle-removing cream, which is prepared from the following raw materials: a low-temperature phase component, a water phase component, an oil phase component, a C component and a D component; the mass ratio of the low-temperature phase component to the water phase component to the oil phase component to the C component to the D component is 8.09: 65.31: 20.86: 1.24: 4.5;

the low temperature phase was the same as example 1 except that: the mass ratio of the skin color improving agent to the skin color improving extract to the betaine to the sodium metabisulfite is 7.22: 0.21: 0.6: 0.06; the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the schizosaccharomyces cerevisiae fermentation product lysate to the rice fermentation product filtrate is 3.5: 2.5: 0.12: 0.1: 1;

the aqueous phase composition was the same as in example 1 except that: the water phase components comprise 4 parts of glycerol, 1.1 parts of butanediol, 0.2 part of allantoin, 0.01 part of sodium hyaluronate and 60 parts of water in parts by weight;

the oil phase components were the same as in example 1 except that: the oil phase components comprise 2.5 parts of glyceryl stearate and PEG-100 stearate, 1.2 parts of cetearyl olive oleate and sorbitan olive oleate, 4 parts of cetearyl alcohol, 3 parts of palmitoyl ethylhexyl ester, 4 parts of caprylic/capric triglyceride, 0.6 part of tocopherol acetate, 2.5 parts of glyceryl triethylhexanoate, 3 parts of polydimethylsiloxane and 0.06 part of bisabolol in parts by weight;

the C component was the same as example 1 except that: the component C comprises 0.04 part of triethanolamine and 1.2 parts of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer by weight;

the component D comprises 0.7 part of 1, 2-pentanediol, 0.7 part of 1, 2-hexanediol, 2.5 parts of 1, 2-butanediol and 0.6 part of p-hydroxyacetophenone in parts by weight.

The preparation method of the whitening and freckle-removing cream is the same as that of the example 1.

Example 3

Embodiment 3 provides a whitening and freckle-removing cream, which is prepared from the following raw materials: a low-temperature phase component, a water phase component, an oil phase component, a C component and a D component; the mass ratio of the low-temperature phase component to the water phase component to the oil phase component to the C component to the D component is 7.16: 70.6: 18.55: 0.93: 2.76;

the low temperature phase was the same as example 1 except that: the mass ratio of the skin color improving agent to the skin color improving extract to the sour bean seed polysaccharide to the betaine to the sodium metabisulfite is 6.2: 0.21: 0.2: 0.5: 0.05; the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the schizolysis yeast fermentation product and the rice fermentation product filtrate is 3: 2: 0.1: 0.1: 1;

the aqueous phase composition was the same as in example 1 except that: the water phase components comprise 5 parts of glycerol, 1 part of butanediol, 0.2 part of allantoin, 0.01 part of sodium hyaluronate and 64.39 parts of water in parts by weight;

the oil phase components were the same as in example 1 except that: the oil phase components comprise 2 parts of glyceryl stearate and PEG-100 stearate, 1 part of cetearyl olive oleate and sorbitan olive oleate, 4 parts of cetearyl alcohol, 3 parts of ethylhexyl palmitat, 3 parts of caprylic/capric triglyceride, 0.5 part of tocopherol acetate, 2 parts of glycerol triethyl hexanoate, 3 parts of polydimethylsiloxane and 0.05 part of bisabolol in parts by weight;

the C component was the same as example 1 except that: the component C comprises 0.03 part of triethanolamine and 0.9 part of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer in parts by weight;

the component D comprises 0.6 part of 1, 2-pentanediol, 0.6 part of 1, 2-hexanediol, 2 parts of 1, 2-butanediol and 0.5 part of p-hydroxyacetophenone in parts by weight.

Example 4

Example 4 provides a whitening and spot-removing cream, which is different from example 3 only in that: the cetearyl olive oleate and sorbitan olive oleate were replaced with olive oil PEG-7 esters, which were purchased from wayside biotechnology limited, guangzhou.

Example 5

Example 5 provides a whitening and spot-removing cream, which is different from example 3 only in that: the pH was adjusted to > 7 by the addition of triethanolamine.

Example 6

Example 6 provides a whitening and spot-removing cream, which is different from example 3 only in that: the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer was replaced with hydroxyethyl cellulose, which was purchased from cypress chemical co.

Performance testing

1. High-temperature stability: the whitening and freckle-removing cream described in examples 1-6 was placed at 48 ℃ for 30 days, and whether or not the phenomenon of demixing occurred after 30 days was observed, and the test results are shown in table 1.

2. Low-temperature stability: the whitening and freckle-removing cream described in examples 1-6 was placed at-18 ℃ for 30 days, and whether the phenomenon of coagulation and agglomeration occurred after 30 days was observed, and the test results are shown in table 1.

3. Storage stability: the whitening and freckle-removing cream described in examples 1-6 was placed in air at 25 ℃ for 12 months, and whether discoloration occurred after 12 months was observed, and the test results are shown in table 1.

TABLE 1

	High temperature stability	Stability at Low temperature	Storage stability
				Example 1	Without delamination	No coagulation and agglomeration	No color change
Example 2	Without delamination	No coagulation and agglomeration	No color change
				Example 3	Without delamination	No coagulation and agglomeration	No color change
Example 4	Layering	Little solidification and no caking	No color change
				Example 5	Without delamination	No coagulation and agglomeration	No color change
Example 6	Little delamination	Solidified cake	No color change

4. And (3) testing the whitening effect: 30 female volunteers with healthy skin (ITA ° values between 28 and 41) were selected and randomly divided into 6 groups of 5 persons; the whitening and freckle-removing cream disclosed in examples 1-6 is used once every night and continuously used for 4 weeks, and the skin color difference before and after use is compared by adopting an instrument efficacy determination and self-evaluation method. Skin MI values were determined using a skin black and red pigment tester MX18 (CK, Germany); and the P value of the cooperation significance difference is analyzed, the P value is larger than 0.05, the significance difference does not exist, the P value is smaller than 0.01, and the test result is shown in a table 2.

TABLE 2

5. Self-evaluation: the whitening and freckle-removing cream described in examples 1-6 is observed for 4 weeks, and the evaluation criteria are as follows: the skin was visibly darkened 1, a little skin darkening was noted 2 when carefully observed, no apparent skin change was noted 3 when carefully observed, a little skin whitening was noted 4 when carefully observed, a little skin whitening was noted 5 when averaged, and the test results are shown in table 3.

TABLE 3

	Skin complexion changes
		Example 1	3.7
Example 2	3.8
		Example 3	4.0
Example 4	3.1
		Example 5	2.9
Example 6	3.2

6. And (3) safety evaluation: the irritation of the whitening and spot-removing cream described in example 3 was measured by the chick embryo chorioallantoic membrane vascular test (CAMVA), and after the chick embryo was incubated up to 4d (incubation temperature: 37 ℃ C., humidity: 60%), 2-3mL of serum was taken out from the bottom by a syringe and sealed with wax, and a window was opened (about 1 cm) above the chick embryo²) Reuse bookSealing with a membrane, opening the window at 14d, placing into a resin ring, dripping 40 μ L of the whitening and freckle-removing cream described in example 3, and placing into an incubator to incubate for 30min to observe bleeding and change. The samples are diluted by water to 70% and 100%, no positive reaction is found at 70%, 1 positive reaction appears in 3 chick embryos of 100% samples, so that 100% is adopted in subsequent formal experiments, 1 positive reaction appears in 10 chick embryos, RC50 (the concentration of the sample when half of chick embryos are positive) is calculated to be more than 100%, and the whitening and freckle-removing cream is non-irritant according to the judgment standard.

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. The whitening and freckle-removing cream is characterized in that the preparation raw materials at least comprise a low-temperature phase component, a water phase component and an oil phase component; the low temperature phase component comprises a composition for improving skin color, acid soybean seed polysaccharide, betaine; the composition for improving skin color comprises a skin toner and a plant extract.

2. The cream for whitening skin and removing freckles as claimed in claim 1, wherein the agent for improving skin color is selected from one or more of niacinamide, tranexamic acid, glabridin, yeast schizolysis ferment and rice ferment filtrate.

3. The cream for whitening and removing freckles according to claim 2, wherein the mass ratio of the nicotinamide, the tranexamic acid, the glabridin, the cracked yeast cell lysis fermentation product and the rice fermentation product filtrate is (2.5-3.5): (1.5-2.5): (0.08-0.12): (0.05-0.15): (0.8-1.2).

4. The cream for whitening and removing freckles as claimed in claim 1, wherein the plant extract is selected from one or more of magnolia sieboldii extract, mulberry root extract, undaria pinnatifida extract, and hypecol callus culture filtrate.

5. The whitening and freckle-removing cream according to claim 4, wherein the mass ratio of the magnolia sieboldii extract to the mulberry root extract to the undaria pinnatifida extract is (0.05-0.15): (0.05-0.15): 0.01.

6. the cream of claim 1, wherein the low temperature phase component further comprises sodium metabisulfite; the mass ratio of the skin toner, the plant extract, the tamarind seed polysaccharide, the betaine and the sodium metabisulfite is (5.5-7.0): (0.2-0.3): (0.1-0.3): (0.4-0.6): (0.04-0.06).

7. The cream with whitening and freckle removing functions of claim 1, wherein the water phase component comprises 3-6 parts by weight of glycerin, 0.8-1.2 parts by weight of butanediol, 0.15-0.25 part by weight of allantoin, 0.01 part by weight of sodium hyaluronate and 60-70 parts by weight of water.

8. The cream for whitening and removing freckles according to claim 1, characterized in that the oil phase component comprises 1.5-2.5 parts of glyceryl stearate and PEG-100 stearate, 0.8-1.2 parts of cetearyl olive oleate and sorbitan olive oleate, 3-5 parts of cetearyl alcohol, 2-4 parts of palmitoyl ethylhexyl ester, 2-4 parts of caprylic/capric triglyceride, 0.4-0.6 part of tocopherol acetate, 1.5-2.5 parts of glyceryl triethylhexanoate, 2-4 parts of polydimethylsiloxane and 0.04-0.06 part of bisabolol in parts by weight.

9. The whitening spot-removing cream according to any one of claims 1 to 8, wherein the preparation raw materials of the whitening spot-removing cream further comprise a component C and a component D; the component C comprises 0.02-0.04 part by weight of triethanolamine and 0.7-1.2 parts by weight of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

10. The preparation method of the whitening and freckle-removing cream according to claim 9 is characterized by comprising the following steps: