CN112315844A - Composition for improving skin color and preparation method and application thereof - Google Patents
Composition for improving skin color and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention relates to the field of cosmetics, in particular to a composition for improving skin color and a preparation method and application thereof. The composition for improving skin color comprises a skin color improving agent and a plant extract; the skin color improving agent comprises one or more of nicotinamide, glabridin, tranexamic acid, yeast bifidus fermentation product lysate, and rice fermentation product filtrate. The composition for improving skin color provided by the invention adopts tranexamic acid and nicotinamide as components for improving skin color, inhibits the activity of tyrosinase, inhibits the oxidation reaction in the melanogenesis process, inhibits the expression and transfer of melanogenesis-related protein, and synergistically inhibits the formation of melanin and color spots in multiple aspects. Through scientific compounding among the skin color improving agent, the plant extract and the aspergillus fermentation product, the whitening effect is more obvious under the synergistic action of various plant extracts, and the composition for improving the skin color can effectively achieve the effect of improving the skin color and simultaneously has excellent stability and long-acting improvement on the quality of the skin.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a composition for improving skin color and a preparation method and application thereof.
Background
Whitening is always sought by asian women, and with the improvement of the living standard and aesthetic standard of people, smooth, fair, and even skin with little speckles or pigment deposition is more and more advocated. The skin color becomes dark due to a plurality of factors such as natural aging and the like, and people can achieve the effect by applying whitening products such as whitening milk, whitening cream, whitening essence and the like. Wherein the whitening agent generally comprises ascorbic acid and its derivatives, arbutin, glabridin, etc. The whitening effect is achieved mainly through the following aspects of firstly inhibiting the enzyme activity related to the synthesis of the eumelanin such as tyrosinase, secondly inhibiting the transfer of the melanin from a basal layer to an epidermal layer, and thirdly promoting the generation of the melatonin so as to inhibit the generation of the eumelanin.
The skin care products sold on the market are various, but the existing whitening products are added with too many synthetic chemical reagents and are easy to damage the skin. Particularly, a cosmetic for partially improving skin color is added with a preparation containing mercury and hydroquinone in a large amount, which can rapidly improve skin color, but the accumulation of toxic substances can lead to facial skin necrosis of consumers, and incurable green spots or white blocks are left. At present, hydroquinone has good whitening effect but has toxicity and carcinogenicity to a human body, so the hydroquinone is forbidden to be used in a resident product; arbutin has good whitening effect, but is easy to generate hydroquinone under certain conditions; ascorbic acid is unstable, easily oxidized in neutral or alkaline solutions, unstable under light and heat conditions, and easily yellowed after storage for a certain period of time, so many ascorbic acid derivatives such as ascorbic acid phosphate, ascorbic acid glucoside, and ascorbic acid ethyl ether appear.
Therefore, there is a need to develop a composition for improving skin color that can improve the stability and efficacy problems of whitening agents in cosmetic formulations.
Disclosure of Invention
In order to solve the above problems, the present invention provides in a first aspect a composition for improving skin color comprising a skin color improving agent, a plant extract; the skin color improving agent comprises one or more of nicotinamide, glabridin, tranexamic acid, yeast bifidus fermentation product lysate, and rice fermentation product filtrate.
As a preferred technical scheme, the skin color improving agent comprises, by weight, 15-20 parts of tranexamic acid, 10-30 parts of nicotinamide, 0.5-1 part of schizosaccharomyces cerevisiae fermentation product lysate, 5-10 parts of rice fermentation product filtrate and 0.5-1 part of glabridin.
As a preferable technical scheme, the mass ratio of the nicotinamide to the glabridin is (20-30): 1.
as a preferable technical scheme, the plant extract comprises one or more of magnolia sieboldii extract, mulberry root extract and undaria pinnatifida extract.
As a preferred technical solution, the plant extract further comprises hypecoum vulgare callus culture filtrate.
As a preferable technical scheme, the plant extract comprises 1 part of Magnolia sieboldii extract, 0.1 part of Undaria pinnatifida extract and 1 part of mulberry root extract in parts by weight.
As a preferred technical scheme, the plant extract also comprises 0.1 part of hypsizygus marmoreus callus culture filtrate in parts by weight.
As a preferable technical scheme, the composition for improving the skin color also comprises 1 part of aspergillus fermentation product by weight.
In a second aspect, the present invention provides a method for preparing the above composition for improving skin color, comprising the steps of:
s1: adding the plant extract, the lysate of the yeast fermentation product of the secondary fission, the filtrate of the rice fermentation product and the fermentation product of the aspergillus into the deionized water in sequence, and stirring uniformly;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
The third aspect of the invention provides the application of the composition for improving skin color in preparing cosmetics for improving skin color.
Has the advantages that: the composition for improving skin color provided by the invention adopts tranexamic acid and nicotinamide as components for improving skin color, inhibits the activity of tyrosinase, inhibits the oxidation reaction in the melanogenesis process, inhibits the expression and transfer of melanogenesis-related protein, and synergistically inhibits the formation of melanin and color spots in multiple aspects. Through scientific compounding among the skin color improving agent, the plant extract and the aspergillus fermentation product, the whitening effect is more obvious under the synergistic action of various plant extracts, and the composition for improving the skin color can effectively achieve the effect of improving the skin color and simultaneously has excellent stability and long-acting improvement on the quality of the skin.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when the range "1 to 5" is disclosed, the described range should be construed as including the ranges "1 to 4", "1 to 3", "1 to 2", "2 to 3" and "3 to 4", "4 to 5" and "3 to 5", etc. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the above technical problems, the present invention provides in a first aspect a composition for improving skin color comprising a skin color improving agent, a plant extract; the skin color improving agent comprises one or more of nicotinamide, glabridin, tranexamic acid, yeast bifidus fermentation product lysate, and rice fermentation product filtrate.
In one embodiment, the mass ratio of the skin toner to the plant extract is 1: 1.
skin color improving agent
In one embodiment, the skin tone improving agent comprises niacinamide, glabridin, tranexamic acid, a yeast bifida fermentation product lysate, a rice fermentation product filtrate.
In a preferred embodiment, the skin color improving agent comprises 15-20 parts by weight of tranexamic acid, 10-30 parts by weight of nicotinamide, 0.5-1 part by weight of yeast fermentation lysate, 5-10 parts by weight of rice fermentation product filtrate and 0.5-1 part by weight of glabridin.
In a more preferred embodiment, the skin color improving agent comprises, by weight, 20 parts of tranexamic acid, 30 parts of niacinamide, 1 part of a saccharomyces bifidus fermentation product lysate, 10 parts of a rice fermentation product filtrate, and 1 part of glabridin.
(tranexamic acid)
In the present invention, the tranexamic acid is also called tranexamic acid (Tranex)amic acid), tranexamic acid, chemical name trans-4-aminomethyl cyclohexanecarboxylic acid, white crystalline powder; no smell, slightly bitter taste. Is easily soluble in water and hardly soluble in ethanol, acetone, chloroform or diethyl ether. Molecular formula C8H15NO2CAS number 1197-18-8, molecular weight 157.21 at 1 standard atmosphere, density 1.095g/cm3The melting point was 233 ℃ and the boiling point was 300.2 ℃.
In one embodiment, the tranexamic acid is purchased from Shanghai Violet Pont biomedical corporation, Inc.
(Nicotinamide)
In the present invention, nicotinamide (niacinamide), also called nicotinamide, is an amide compound of nicotinic acid. A crystalline powder that is white; no or almost no odor, bitter taste; it is slightly hygroscopic. It is easily soluble in water or ethanol, and soluble in glycerol. Chemical formula C6H6N2O, molecular weight 122.13, CAS number 98-92-0.
In one embodiment, the nicotinamide is purchased from cypress chemical company, ltd.
In one embodiment, the mass ratio of niacinamide to glabridin is (20-30): 1; preferably, the mass ratio of the nicotinamide to the glabridin is 30: 1.
the tranexamic acid and the nicotinamide are used as components for improving skin color, inhibiting activity of tyrosinase, inhibiting oxidation reaction in a melanogenesis process, inhibiting expression and transfer of melanogenesis-related protein, and inhibiting formation of melanin and color spots in a multi-aspect synergistic manner. Particularly, the glabridin and the nicotinamide have a compound synergistic effect, and the whitening effect is more obvious when the glabridin and the nicotinamide are matched together.
(two cracking yeast fermentation lysate)
In the present invention, the lysate of the fermentation product of the binary split yeast is a chemical substance, and the CAS number is 96507-89-0. Is prepared from Bifidobacterium through culturing, deactivating and decomposing to obtain metabolite, cytoplasm segment, cell wall component and polysaccharide complex. The lysate of the yeast fermentation product has strong anti-immunosuppression activity, can promote DNA repair, can effectively protect skin from being damaged by ultraviolet rays, is used for skin care, sun protection and after-sun care products of emulsion, water-based and hydroalcoholic systems, and helps to prevent photoaging of epidermis and dermis. The yeast fermentation product lysate can generate small molecules which comprise vitamin B group, minerals, amino acids and the like and are beneficial to skin care, and the yeast essence is high-quality yeast essence only used for skin care. It has effects in promoting metabolism of stratum corneum, capturing free radicals, inhibiting lipid peroxidation, whitening skin, and resisting aging. The product is rich in nutrients, and has skin nourishing effect.
In one embodiment, the split yeast fermentation product lysate is purchased from cypress chemical company, ltd.
(Rice fermentation product filtrate)
In the invention, the rice fermentation product filtrate is a natural rice bran fermentation product, has the whitening effect, and can inhibit the growth of melanin and the activation of the tyrosinase. But the generation of cholesterol and ceramide is promoted, the cholesterol and the ceramide are important components of sebum, and the increase of the content of the cholesterol and the ceramide is helpful for improving the skin softness, so the cholesterol and the ceramide have the conditioning effect; has effects of activating glutathione reductase, improving skin activity and resisting aging.
In one embodiment, the rice fermentation product filtrate is of the brand number
XGN, purchased from New chemical industries, Inc.
(Glabridin)
In the invention, the glabridin is a flavonoid substance and is extracted from a precious plant called glabrous licorice, and the glabridin is known as whitening gold because of the strong whitening effect, can eliminate free radicals and muscle bottom melanin and is a whitening and anti-aging holy substance for skin. The molecular formula is as follows: c20H20O4CAS number: 59870-68-7. It shows strong anti-free radical oxidation effect in cytochrome P450/NADPH oxidation system, and can obviously inhibit the production in the metabolism process in vivoFree radicals are generated to protect against oxidation-sensitive biological macromolecules (low density lipoprotein LDL, DNA) and cell walls etc. from damage by free radical oxidation. Thereby preventing and treating certain pathological changes related to free radical oxidation, such as atherosclerosis, cell aging and the like. In addition, glabridin has certain functions of lowering blood fat and lowering blood pressure.
In one embodiment, the glabridin is purchased from oxsnow chemical, inc.
The composition for improving skin color provided by the invention adopts tranexamic acid and nicotinamide as components for improving skin color, inhibits the activity of tyrosinase, inhibits the oxidation reaction in the melanogenesis process, inhibits the expression and transfer of melanogenesis-related protein, and synergistically inhibits the formation of melanin and color spots in multiple aspects.
Plant extracts
In one embodiment, the plant extract comprises one or more of magnolia sieboldii extract, mulberry root extract, undaria pinnatifida extract.
In a preferred embodiment, the plant extract comprises 1 part by weight of magnolia sieboldii extract, 0.1 part by weight of undaria pinnatifida extract and 1 part by weight of mulberry root extract.
(Magnolia sieboldii extract)
In the invention, the magnolia sieboldii extract is extracted from flowers and branches of magnolia sieboldii, is a component with a whitening effect, and can be used as a skin conditioner.
In one embodiment, the Magnolia sieboldii extract is purchased from Brandy corporation.
(Undaria pinnatifida extract)
The undaria pinnatifida extract is a pure natural surfactant, has excellent oxidation resistance, antibacterial property, anti-inflammatory property and dispersing capacity, and is used as a skin conditioner and a skin protective agent.
In one embodiment, the undaria pinnatifida extract is purchased from austempered chemical ltd, guangzhou.
(Mulberry root extract)
In the invention, the mulberry root extract contains a plurality of effective substances such as mulberroside and the like, can powerfully take out free radicals, inhibit tyrosinase activity, inhibit indirect melanin formation, effectively relieve pressure and keep a pleasant mood.
In one embodiment, the mulberry root extract is purchased from clariant corporation.
According to the skin-color-improving composition, the magnolia sieboldii extract, the undaria pinnatifida extract and the mulberry root extract are compounded, the skin-whitening effect is more obvious by utilizing the synergistic effect of the plant extracts, the skin-color-improving composition can effectively achieve the effect of improving skin color, can improve the effect of improving a skin-color agent, and has excellent stability and long-acting improvement on the quality of skin.
In one embodiment, the plant extract further comprises a hypecoum vulgare callus culture filtrate.
(Criste anisetree callus culture filtrate)
In the invention, the hypecoum anisopliae callus culture filtrate is used as a skin protective agent, is a plant stem cell extract, has the effects of resisting inflammation and skin aging, and has no side effect on skin after long-term use. The natural plant moisture-retaining essence can effectively improve the primary aging phenomena of dryness, roughness, darkness, dry wrinkles, looseness and the like of skin caused by nutrient loss.
In one embodiment, the hypsizygus marmoreus callus culture filtrate is purchased from baihabo corporation.
In another preferred embodiment, the plant extract comprises 1 part of magnolia sieboldii extract and 0.1 part of hypecoum vulgare callus culture filtrate by weight.
According to the invention, the magnolia sieboldii extract and the hypsizygus marmoreus callus culture filtrate are compounded, the whitening effect is more obvious by utilizing the synergistic effect of the plant extracts, and the composition for improving the skin color can effectively achieve the effect of improving the skin color, has excellent stability and long-acting quality of improving the skin, and can improve the moisturizing effect of the composition for improving the skin color.
In the invention, the plant extracts are compounded in a way including but not limited to the enumerated modes, and any 3 or 4 of the magnolia sieboldii extract, the mulberry root extract, the undaria pinnatifida extract and the hypsizygus marmoreus callus culture filtrate have excellent skin color improving effect.
In one embodiment, the composition for improving skin color further comprises 1 part by weight of a fermentation product of aspergillus.
Aspergillus fermentation products
According to the invention, the aspergillus fermentation product is obtained by fermenting aspergillus, is a skin whitening agent, can inhibit tyrosinase activity in a human body, can reduce melanin of the skin after a period of time, relieves pigmentation, and helps to expel toxin and regenerate the skin.
In one embodiment, the aspergillus fermentation product is purchased from behabo corporation.
In one embodiment, the composition for improving skin tone further comprises 25 to 60 parts by weight of deionized water; preferably, the composition for improving skin color further comprises 45 parts by weight of deionized water.
The skin color improving composition comprises specific components of a skin color improving agent, tranexamic acid, nicotinamide, a schizosaccharomyces cerevisiae fermentation product lysate, a rice fermentation product filtrate, glabridin, a specific plant extract and an aspergillus fermentation product, and has no layering phenomenon after being placed at 48 ℃ for 30 days and no solidification phenomenon after being placed at-18 ℃ for 30 days. Can significantly reduce the content of skin melanin and has the effects of whitening and lightening the skin melanin.
In a second aspect, the present invention provides a method for preparing the above composition for improving skin color, comprising the steps of:
s1: adding the plant extract, the lysate of the yeast fermentation product of the secondary fission, the filtrate of the rice fermentation product and the fermentation product of the aspergillus into the deionized water in sequence, and stirring uniformly;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
The applicant unexpectedly finds that the plant extract, the schizosaccharomyces cerevisiae fermentation product lysate, the rice fermentation product filtrate and the aspergillus fermentation product are sequentially added, so that the skin melanin content can be further reduced, the skin whitening and skin melanin lightening effects are achieved, the skin whitening effect can be kept for a long time by subsequently adding the nicotinamide, the glabridin and the tranexamic acid, more importantly, the stability of the composition for improving the skin color is improved, the composition is free of layering phenomenon after being placed at 48 ℃ for 30 days, and the composition is free of solidification phenomenon after being placed at-18 ℃ for 30 days.
The third aspect of the invention provides the application of the composition for improving skin color in preparing cosmetics for improving skin color.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
The raw materials used in examples 1-7 and their manufacturers were:
the tranexamic acid was purchased from Shanghai purple Banghai biomedicine, Inc.;
the nicotinamide was purchased from cypress chemical company, ltd;
the two split yeast fermentation product lysate purchased from cypress chemical company;
the rice fermentation product filtrate has the brand number of
XGN, purchased from New chemical industries, Inc.;
the glabridin is purchased from Orxue chemical Co., Ltd, Guangzhou city;
the Magnolia sieboldii extract was purchased from Bailander;
the undaria pinnatifida extract is purchased from Oxue chemical Co., Ltd, Guangzhou;
the mulberry root extract is purchased from clariant corporation;
the hypsizygus marmoreus callus culture filtrate was purchased from baihaobo corporation;
the Aspergillus fermentation product was purchased from Baihabo Co.
Example 1
Embodiment 1 provides a composition for improving skin color, comprising, in parts by weight: 20 parts of tranexamic acid, 30 parts of nicotinamide, 1 part of schizosaccharomyces fermentation product lysate, 10 parts of rice fermentation product filtrate, 1 part of glabridin, 1 part of magnolia sieboldii extract, 0.1 part of undaria pinnatifida extract, 1 part of mulberry root extract, 1 part of aspergillus fermentation product and 35 parts of deionized water;
the preparation method of the composition for improving skin color comprises the following steps:
s1: sequentially adding Undaria pinnatifida extract, Magnolia sieboldii extract, mulberry root extract, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate and aspergillus fermentation product into deionized water, and uniformly stirring;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
Example 2
Embodiment 2 provides a composition for improving skin color, comprising, in parts by weight: 20 parts of tranexamic acid, 30 parts of nicotinamide, 1 part of schizosaccharomyces fermentation product lysate, 10 parts of rice fermentation product filtrate, 1 part of glabridin, 2 parts of magnolia sieboldii extract, 0.1 part of undaria pinnatifida extract, 2 parts of mulberry root extract, 3 parts of aspergillus fermentation product and 31 parts of deionized water;
the composition for improving skin color was prepared in the same manner as in example 1.
Example 3
Embodiment 3 provides a composition for improving skin color, comprising, in parts by weight: 15 parts of tranexamic acid, 10 parts of nicotinamide, 0.5 part of schizosaccharomyces fermentation product lysate, 5 parts of rice fermentation product filtrate, 0.5 part of glabridin, 4 parts of magnolia sieboldii extract, 0.1 part of undaria pinnatifida extract, 2 parts of mulberry root extract, 4 parts of aspergillus fermentation product and 59 parts of deionized water;
the composition for improving skin color was prepared in the same manner as in example 1.
Example 4
Embodiment 4 provides a composition for improving skin color, comprising, in parts by weight: 20 parts of tranexamic acid, 30 parts of nicotinamide, 1 part of schizosaccharomyces fermentation product lysate, 10 parts of rice fermentation product filtrate, 1 part of glabridin, 3 parts of magnolia sieboldii extract, 0.5 part of hypecol callus culture filtrate, 4 parts of aspergillus fermentation product and 34 parts of deionized water;
the preparation method of the composition for improving skin color comprises the following steps:
s1: sequentially adding Magnolia sieboldii extract, Crithmum maritimum callus culture filtrate, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate and Aspergillus fermentation product into deionized water, and stirring uniformly;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
Example 5
Example 5 provides a composition for improving skin color, which is the same as example 1 except that 0 part of an undaria pinnatifida extract;
the preparation method of the composition for improving skin color comprises the following steps:
s1: sequentially adding Magnolia sieboldii extract, mulberry root extract, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate and aspergillus fermentation product into deionized water, and uniformly stirring;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
Example 6
Example 6 provides a composition for improving skin color, which is the same as example 1 except that 0 part of the koji mold fermentation product and 0 part of the rice fermentation product filtrate;
the preparation method of the composition for improving skin color comprises the following steps:
s1: sequentially adding Undaria pinnatifida extract, Magnolia sieboldii extract, mulberry root extract and schizosaccharomyces cerevisiae fermentation product lysate into deionized water, and uniformly stirring;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
Example 7
Example 7 provides a composition for improving skin tone, as in example 1;
the preparation method of the composition for improving skin color comprises the following steps:
adding nicotinamide, glabridin, tranexamic acid, undaria pinnatifida extract, magnolia sieboldii extract, mulberry root extract, schizosaccharomyces cerevisiae fermentation product lysate, rice fermentation product filtrate and aspergillus fermentation product into deionized water, and uniformly stirring to obtain the composition for improving the skin color.
Performance testing
1. High-temperature stability: the skin color improving compositions described in examples 1-7 were allowed to stand at 48 ℃ for 30 days, and observed for delamination after 30 days, the test results are shown in table 1.
2. Low-temperature stability: the skin color improving compositions described in examples 1 to 7 were left at-18 ℃ for 30 days, and whether or not coagulation occurred after 30 days was observed, and the test results are shown in table 1.
TABLE 1
| High temperature stability | Stability at Low temperature | |
| Example 1 | Without delamination | Without coagulation |
| Example 2 | Without delamination | Without coagulation |
| Example 3 | Without delamination | Without coagulation |
| Example 4 | Without delamination | Without coagulation |
| Example 5 | Layering | Slightly solidified |
| Example 6 | Without delamination | Slightly solidified |
| Example 7 | Little delamination | Coagulation |
3. And (3) testing the efficacy: the compositions for improving skin color described in examples 1 to 7 were tested for their inhibition of tyrosine by the tyrosinase inhibition method, which specifically comprises: taking L-tyrosine as a substrate, taking a 10mL centrifuge tube, adding a tyrosine solution (2mmol/L), PBS and a composition for improving the skin color by 1% according to the dosage of the following table 2, shaking uniformly, and carrying out constant-temperature water bath at 37 ℃ for 10 min. And sequentially adding tyrosinase (1mg/mL) into test tubes with different numbers every 1min, shaking uniformly, quickly putting into a constant-temperature water bath kettle at 37 ℃, and performing enzymatic reaction for 10min, and then measuring the absorbance value at 475 nm. Each group is provided with 3 parallels; the inhibition rate of tyrosinase by the skin color improving compositions (samples) described in examples 1-7 was calculated as follows, wherein a is the sample + substrate + enzyme absorbance; b is the absorbance of the sample + substrate; c is the absorbance of the substrate + enzyme; d is the absorbance of the substrate.
The results of the test of the inhibition rate of tyrosine by the skin color improving compositions of examples 1 to 7 are shown in table 3.
TABLE 2 monophenolase Activity inhibition test reaction solution composition
| Test number | 1 | 2 | 3 | 4 | C | D | B |
| 2mmol/L tyrosine/mL | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 |
| PBS/mL | 0.30 | 0.30 | 0.30 | 0.30 | 0.50 | 1.00 | 0.80 |
| sample/mL | 0.20 | 0.20 | 0.20 | 0.20 | 0 | 0 | 0.20 |
| 1mg/mL tyrosinase/mL | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0 | 0 |
TABLE 3
| Inhibition ratio (%) | |
| Example 1 | 90.49 |
| Example 2 | 91.90 |
| Example 3 | 89.55 |
| Example 4 | 91.70 |
| Example 5 | 77.68 |
| Example 6 | 71.30 |
| Example 7 | 69.89 |
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. A composition for improving skin color comprises a skin color improving agent, a plant extract; the skin color improving agent comprises one or more of nicotinamide, glabridin, tranexamic acid, yeast bifidus fermentation product lysate, and rice fermentation product filtrate.
2. The composition for improving skin color according to claim 1, wherein the skin color improving agent comprises 15 to 20 parts by weight of tranexamic acid, 10 to 30 parts by weight of niacinamide, 0.5 to 1 part by weight of yeast fermentation lysate, 5 to 10 parts by weight of rice fermentation product filtrate, and 0.5 to 1 part by weight of glabridin.
3. The composition for improving skin color according to claim 2, wherein the mass ratio of niacinamide to glabridin is (20-30): 1.
4. the composition for improving skin color according to claim 1, wherein the plant extract comprises one or more of magnolia sieboldii extract, mulberry root extract, and undaria pinnatifida extract.
5. The composition for improving skin color according to claim 4, wherein the plant extract further comprises a hypsizygus marmoreus callus culture filtrate.
6. The composition for improving skin color according to claim 4, wherein the plant extract comprises 0.5 to 5 parts by weight of Magnolia sieboldii extract, 0.1 part by weight of Undaria pinnatifida extract, and 1 to 2 parts by weight of Morus alba root extract.
7. The composition for improving skin color according to claim 5, wherein the plant extract further comprises 0.1 to 0.5 parts by weight of hypecoum vulgare callus culture filtrate.
8. The composition for improving skin color according to any one of claims 1 to 7, wherein the composition for improving skin color further comprises 1 to 5 parts by weight of a product of fermentation of Aspergillus.
9. A method of preparing the composition for improving skin color according to claim 8, comprising the steps of:
s1: adding the plant extract, the lysate of the yeast fermentation product of the secondary fission, the filtrate of the rice fermentation product and the fermentation product of the aspergillus into the deionized water in sequence, and stirring uniformly;
s2: adding nicotinamide, glabridin and tranexamic acid, and stirring uniformly to obtain the composition for improving skin color.
10. Use of the composition for improving skin color according to any one of claims 1 to 8 for preparing a cosmetic for improving skin color.
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| CN114712258B (en) * | 2022-04-29 | 2023-02-03 | 广州市百好博有限公司 | Cosmetic composition with antioxidant, anti-wrinkle and repairing effects |
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