KR102247965B1 - Cosmetic Composition for Whitening of the Skin Comprising the Extract of Fermented Zea Mays Silk - Google Patents

Abstract

The present invention relates to a cosmetic composition and a cosmetic method for skin whitening comprising a fermented corn beard obtained by culturing corn beard with yeast ( Saccharomyces cerevisiae ) or lactic acid bacteria (lactobacillus). According to the invention The corn beard fermentation broth is excellent in inhibiting melanin production and tyrosinase activity, and the cosmetic composition for skin whitening comprising the corn beard fermentation broth of the present invention is excellent in whitening effect.

Description

Cosmetic Composition for Whitening of the Skin Comprising the Extract of Fermented Zea Mays Silk

The present invention relates to a cosmetic composition for skin whitening comprising a fermented corn beard. More specifically, it relates to a cosmetic composition for skin whitening comprising a fermented corn beard obtained by culturing corn beard with yeast or lactic acid bacteria.

Factors that determine skin color include spots, freckles and tanning caused by UV exposure, or overall pigmentation, as well as acne and scars, and the distribution status of dead skin cells, excluding differences according to race, region, sex, and age. There are blood circulation, stress, and health conditions. Among the above factors, the most important factor is pigmentation. Pigments that affect skin color include melanin, melazoid, carotene, hemoglobin, and carotenoids, and various colors of skin, hair and eyes are determined by these pigments. Among them, the most important factor in determining the color of the skin is melanin, and the most important factors affecting the biosynthesis of this melanin are ultraviolet rays and the secretion of hormones in the body. Melanin absorbs or scatters ultraviolet rays and plays a big role in preventing skin damage from ultraviolet rays. There is no special maximum absorption wavelength and absorbs light in all areas. In addition, the function of removing active oxygen species is excellent, but sometimes melanin itself generates active oxygen, and it reduces or oxidizes other substances by catechols or quinones in the melanin structure, and melanin itself exhibits the properties of free radicals. I pray.

The biosynthesis of melanin begins with tyrosine, a type of amino acid, being oxidized by tyrosinase in melanosomes of melanocytes and converted to dihydroxy phenylalanine. It is formed from a black (eumelanin) polymer. This biosynthetic process proceeds in a special type of brown intracellular organelle called melanosomes, and melanosomes including melanin granules move from the periphery of the nucleus to the ends of the dendritic processes and move into the cytoplasm by phagocytosis of keratinocytes. Accumulates around the nucleus.

The synthesis of melanin, the number of melanosomes, and migration to the surrounding keratinocytes are partially affected by hormones and ultraviolet rays, and primarily genetically affected. In addition, it is known that metal ions such as cytokines, copper, zinc, iron, and interferon, prostaglandins, and histamines, which are intracellular regulators involved in the expression of tyrosinase and synthesis and transmission of melanin, are known to be involved.

On the other hand, in recent years, many cosmetic companies are making great efforts to develop skin whitening ingredients, and they also apply active ingredients obtained through fermentation to products.

For example, there is a case to provide a cosmetic composition using a fermentation broth produced using a fermentation product by Bacillus bacillus used in typical fermented foods such as cheonggukjang and natto. Such fermentation broth has the advantage of reducing skin irritation by decomposing irritants by microorganisms or converting them into other substances, and fermentation products by microorganisms are also widely used because they have a good effect on the skin.

The present inventors also developed a product using natural products for this purpose, and studied to increase the effect of the corn beard extract, which is known to help skin whitening, than the conventional corn beard extract by fermenting it.

The present inventors searched for various skin physiological activities for natural plant ingredients in order to improve skin pigmentation. As a result, the fermentation broth obtained by culturing corn beard with yeast or lactic acid bacteria among natural plant extracts has the effect of inhibiting tyrosinase activity and melanin. The present invention was completed by confirming that it was possible to effectively improve skin whitening by suppressing the production inhibitory effect, skin pigmentation, and the like.

It is an object of the present invention to provide a cosmetic composition for skin whitening comprising a fermented corn beard.

In addition, another object of the present invention is to provide a cosmetic method, characterized in that it suppresses tyrosinase activity by applying a cosmetic composition for skin whitening comprising a fermented corn beard to the skin, inhibiting melanin production and exhibiting a whitening effect. It is to do.

The above object is achieved by a cosmetic composition for skin whitening comprising a corn beard fermentation broth obtained by culturing corn beard with yeast or lactic acid bacteria.

Preferably, the corn beard fermentation broth is a fermentation broth obtained by culturing corn beard using Saccharomyces cerevisiae as yeast or Bifidobacterium as lactic acid bacteria.

In addition, preferably, the fermented corn beard is characterized in that it is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition.

In addition, preferably, the fermented corn beard broth is characterized in that it inhibits melanin production and inhibits tyrosinase activity.

In addition, preferably, the cosmetic composition is a group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleansing, an oil, a powder foundation, an emulsion foundation, a wax foundation, and a spray. It is characterized by having a formulation selected from.

The cosmetic composition of the present invention, as an active ingredient, contains a fermentation broth obtained by culturing corn beard with yeast or lactic acid bacteria, and thus has excellent melanin production inhibitory effect and tyrosinase activity inhibitory effect, thus exhibiting excellent whitening effect. In addition, the cosmetic composition containing the corn beard fermentation broth of the present invention has excellent whitening effect compared to the conventional cosmetic composition containing corn beard extract.

The present invention provides a cosmetic composition for skin whitening comprising a fermented corn beard.

Corn beard used as an active ingredient in the composition of the present invention is corn of the rice family in Korea ( Zea mays Linn ) refers to fresh flower stalks (flowers: 花柱) and pistils heads (main heads: 柱頭).

Okchokseoye refers to the collection and drying of the beards of corn native to tropical America. This drug smells a little peculiar, tastes sweet and light, and its nature is not biased towards either side. Okchok calligraphy is used for swelling caused by pyelonephritis, when urine does not come out well, jaundice hepatitis, cholecystitis, gallbladder stones, and high blood pressure. As pharmacological action, diuretic action, promotion of bile secretion, lowering of blood pressure and blood sugar, and hemostatic action have been reported.

The shape of the corn whiskers is tangled with each other in the shape of fine threads or hairs to form a loose lump, and it has a pale green to yellowish green or yellowish brown color. The quality is soft, very light and glossy. Other names include Okmisu, Okmacsu, Okgoryang, Pogoksu, Okcheokseo, Okmibal, Okbal, etc. There is this. Compound leaves come out.

Until recently, corn beard has been used in the form of a dry powder or for facial massage by dipping it in water or honey, or as corn beard tea made by mixing corn beard and Cassia tora.

In the present specification, the term "corn beard" preferably means a flower stalk and a pistil head of corn.

The corn beard fermentation broth used in the present invention is characterized in that it is a corn beard fermentation broth obtained by culturing corn beard using yeast or lactic acid bacteria.

The yeast fungus used to ferment the corn beard of the present invention belongs to eukaryotic microorganisms (organisms in which the nucleus and cytoplasm are divided by the nuclear membrane) and has organelles such as cell walls, cell membranes, nuclei, crypts and granules. Those with no gender distinction are mainly reproduced by budding, but among many isolated yeasts, there is no fermentation ability, proliferation by fission or bud-fission instead of germination, and injection rather than ascospore. There are also various groups of yeast, such as the formation of ballistospores or no spore formation. The size is usually 5-10×5-12 μm, which is 5 to 10 times the size of bacteria, and the appropriate pH is 4.5 to 5.5, but survives even at pH 1 to pH 10. Yeast, which survives 12 hours at pH 1, is more acid-resistant than bacteria, so setting the pH of the medium to 3.5 to 3.8 can suppress bacterial contamination to some extent.

Yeast is slightly different depending on the species, but most grow well at 20~25℃. Normally, it is said to die above 50℃, but it can be overcome to some extent by directly adding growth factors that cannot be synthesized above that temperature. Saccharomyces cerevisiae dies at 40℃ or higher, but it can be prevented by adding oleic acid and ergosterol to the medium. The yeast cells themselves are single-celled plants and contain large amounts of protein and trace minerals. A preferred yeast for use in fermenting the corn beard of the present invention is Saccharomyces cerevisiae.

The lactic acid bacteria used to ferment the corn beard of the present invention is a kind of microorganism that is beneficial to the human body, and is a fungus that generates organic acids such as lactic acid (lactic acid) or acetic acid by decomposing carbohydrates such as glucose or lactose. When lactic acid bacteria make lactic acid from sugar, it is called fermentation, and fermented food is made through this fermentation process. In the present invention, Bifido bacterium was used among representative lactic acid bacteria (Lactobacillus, Streptococcus, Bifido Bacterium, Leukono Stock, Pediococcus, Lactococcus).

In the present invention, the fermented corn beard broth is prepared as follows:

a) finely making corn beard powder using 100 to 500 mesh;

b) adding 1 to 50 g/L of the corn beard powder prepared in step a) to a conventional microbial culture solution, and adding a yeast strain or lactic acid bacteria in an amount of 10,000 to 100,000 cfu/L;

c) culturing the culture of step b) at 30-37° C., pH 5-7 under aerobic or usually anaerobic conditions for about 5 to 10 days; And

d) filtering the culture solution of step c) and then aging at low temperature for 5 to 10 days to filter.

According to a preferred embodiment of the present invention, the fermented corn beard broth used in the present invention was prepared as follows:

After powdering the corn beard powder into 300 mesh, 10 g/L was added to the culture solution, and yeast strains or lactic acid bacteria were added at 50,000 cfu/L. Incubate for about 7 days in a fermenter under conditions. After cultivation, a culture solution is obtained, and the culture solution is filtered using 0.25 μM filter paper. The filtrate is further aged at low temperature for 10 days, filtered, and concentrated to prepare a corn beard fermentation broth of the present invention.

In the present invention, the fermented corn beard broth has features of improving skin whitening by inhibiting tyrosinase activity and inhibiting melanin production.

In the present invention, the content of the corn beard fermentation broth is 0.0001 to 30.0% by weight, more preferably 0.001 to 20% by weight, based on the total cosmetic composition. If the content of the corn beard fermentation broth is less than 0.0001% by weight, you cannot expect a clear skin whitening improvement effect, and when the content of the corn beard fermentation broth exceeds 30.0% by weight, there is no apparent increase in the effect due to the increase in the content, and skin irritation. Or a problem in the stability of the formulation.

Ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to fermented corn whiskers as an active ingredient, for example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, And a carrier.

The cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , Oil, powder foundation, emulsion foundation, wax foundation, and may be formulated as a spray, but is not limited thereto. In more detail, it may be prepared in the form of a flexible lotion (skin), nourishing lotion (milk lotion), nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder. .

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as a carrier component. I can.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / May contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, and crystallites Sex cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.

When the formulation of the present invention is a surfactant containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters may be used.

In addition, the present invention provides a cosmetic method characterized in that it suppresses tyrosinase activity and melanin production by applying a cosmetic composition for skin whitening comprising a fermented corn beard to human skin.

The cosmetic method of the present invention refers to all cosmetic methods in which the cosmetic composition of the present invention is applied to human skin. That is, all methods known in the art for applying the cosmetic composition to the skin belong to the cosmetic method of the present invention.

The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in duplicate with other cosmetic compositions other than the present invention. In addition, the cosmetic composition having excellent skin whitening effect according to the present invention may be used according to a conventional method of use, and the number of times of use thereof may be varied according to a user's skin condition or taste.

When the cosmetic composition of the present invention is a soap, a cleansing formulation containing a surfactant, or a cleansing formulation containing no surfactant, it may be applied to the skin and then wiped off, removed, or washed off with water. As a specific example, the soap is liquid soap, powder soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water, and cleansing gel, but is not limited thereto.

When the cosmetic composition comprising the fermented corn beard of the present invention is applied to the human skin, a cosmetic composition can be applied to the human skin, thereby inhibiting tyrosinase activity and melanin production, and improving skin pigmentation to obtain a skin whitening effect.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Manufacturing example 1. Preparation of fermented corn whisker yeast fermentation broth using yeast

After washing with purified water and pulverizing dried corn beard, it was made fine using 300 mesh. This was added to the yeast culture (Potato Dextrose Broth, Accumedia, United States of America) at 10 g/L. The yeast strain used for fermentation was Saccharomyces cerevisiae , and 50,000 cfu/L per culture was added. Culture was carried out using a 5L fermenter for 7 days, maintaining at 30°C and pH 5-7. After cultivation, the culture medium was centrifuged to remove the cultured bacteria first, and the final filtration was performed using 0.25 μM filter paper. The filtrate thus obtained was further aged for about 10 days in a low temperature warehouse at 4° C., and the filtered aged solution was filtered again using a 0.25 μM filter and used in the present invention. The fermentation broth prepared in this way is hereinafter collectively referred to as'corn salt yeast fermentation broth'. The corn beard yeast fermentation broth used in the following experimental examples was used by maintaining the final concentration to 1g/100mL.

Manufacturing example 2. Bifidobacterium Manufacture of fermentation broth of lactic acid bacteria using corn whisker strains

After washing with purified water and pulverizing dried corn beard, it was made fine using 300 mesh. This was added to the lactic acid bacteria culture medium at 10 g/L. Glucose as a carbon source and dipotassium phosphate as a pH adjuster were added thereto. Bifidobacterium was used as the lactic acid bacteria used at this time, and 50,000 cfu/L per culture solution was added. Culture was carried out using a 5L fermenter for 7 days, maintaining at 37°C and pH 5-7. After cultivation, the culture solution was centrifuged to remove the cultured bacteria first, and the final filtration was performed using 0.25 μM filter paper. The filtrate thus obtained was further aged for about 10 days in a low temperature warehouse at 4° C., and the filtered aged solution was filtered again using a 0.25 μM filter and used in the present invention. The fermentation broth prepared in this way is hereinafter collectively referred to as “corn lactic acid bacteria fermentation broth”. The fermentation broth of lactic acid bacteria used in the following experiment was used by maintaining the final concentration of 1g/100mL.

Manufacturing example 3. Corn beard extract manufacturing

Corn beard was washed with purified water, dried, powdered, and then 100 g was added to 0.6 L of 70% ethanol solution, followed by heat extraction for 4 hours in a reflux extractor equipped with a cooling condenser. Then, the obtained extract was filtered through a 300 mesh filter cloth, filtered through filter paper No. 5, the solvent was removed using a vacuum concentrator, and freeze-dried to obtain 5.5 g of dry weight. The extract thus obtained is hereinafter collectively referred to as'corn beard extract', and the corn beard extract was used so that the final concentration was 1 g/100 mL.

Experimental example 1: Experiments on the inhibition of tyrosinase activity of fermented corn beard broth

As a substrate, 40 µl of 1.5 mmol/L tyrosine (Sigma, USA) dissolved in sodium phosphate buffer (pH 6.8) was used. The corn beard yeast fermentation broth prepared in Preparation Example 1 and the corn beard lactic acid bacteria fermentation broth prepared in Preparation Example 2 were diluted with 0.05 M sodium phosphate buffer solution (pH 6.8) to prepare sample solutions for each concentration (0.5%, 1.0%). . 240 µl of the sample solution for each concentration was added to 40 µl of tyrosine, 20 µl of tyrosinase (Sigma, 1500 U/ml) was added to the solution, followed by reaction at 37° C. for 15 minutes, and then at 490 nm. The absorbance was measured. As a comparative group, the corn beard extract of Preparation Example 3 was used instead of the corn beard fermentation broth. As a control, the fermentation broth was not treated.

The degree of inhibition of the activity of tyrosinase was calculated according to Equation 1 below. The experimental results are shown in Table 1 below.

division Test substance concentration (%) Tyrosinase activity inhibition rate (%) Manufacturing Example 1 0.5% 44.7 1.0% 62.6 Manufacturing Example 2 0.5% 53.9 1.0% 74.8 Manufacturing Example 3 0.5% 31.6 1.0% 45.8

From the above results, when the corn beard yeast fermentation broth and corn beard lactic acid bacteria fermentation broth were treated, the tyrosinase activity inhibitory effect was superior compared to the corn beard extract (comparative group), and from this, the corn beard fermentation broth inhibited melanin production. It was found that it could solve the skin pigment problem.

Experimental example 2: Experiment on inhibition of melanin biosynthesis of fermented corn whisker broth

B-16 cells (mouse melanoma cells, Korea Cell Line Bank) were inoculated into a 6-well plate at 1×10 ⁵ cells/well and cultured for 24 hours. Each well was treated with 0.5% and 1% corn beard fermentation broth, and cultured for 3 to 4 days, and then the culture broth of each well was centrifuged. The separated cells were dissolved in 500 µl of 1N NaOH solution dissolved in dimethyl sulfoxide (DMSO) and heated in a 90° C. water bath for 10 minutes. This supernatant was measured for absorbance at 490 nm. As a control, the fermentation broth was not treated. The melanin production inhibition rate was calculated according to Equation 2 below, and the results are shown in Table 2.

division Test substance concentration (%) Melanogenesis inhibition rate (%) Manufacturing Example 1 0.5% 34.8 1.0% 79.1 Manufacturing Example 2 0.5% 46.5 1.0% 85.9 Manufacturing Example 3 0.5% 35.6 1.0% 56.6

Through the above results, when the corn beard yeast fermentation broth and corn beard lactic acid bacteria fermentation broth were treated, the tyrosinase activity inhibitory effect and melanin biosynthesis inhibitory effect were superior compared to the corn beard extract (comparative group). It was found that the problem of skin pigmentation could be solved by suppressing melanin production. Hereinafter, based on the results of the above-described experimental examples, a cosmetic composition comprising the fermented corn and whisker liquid of the present invention is prepared and presented. However, it is not intended to limit the composition of the present invention to the following prescription examples. The corn beard fermentation broth used in the following formulation examples may be either corn beard yeast fermentation broth or corn beard lactic acid bacteria fermentation broth.

Formulation example 1: flexible lotion

Among the cosmetics containing fermented corn whiskers, examples of the prescription of softening lotion are as follows.

ingredient Content (% by weight) Corn beard fermentation broth 0.5 glycerin 5.0 1.3-butylene glycol 3.0 Allantoin 0.1 DL-panthenol 0.3 E.D.T.A-2NA 0.02 Benzophenone-9 0.04 Sodium hyaluronate 5.0 Nicole HCO 60 0.4 Methyl paraben 0.2 incense, 0.01 Distilled water Balance Sum 100

Formulation example 2: nourishing lotion

Examples of the prescription of nutrient cosmetic water among cosmetics containing fermented corn beard liquid are as follows.

ingredient Content (% by weight) Corn beard fermentation broth 2.0 Glyceryl stearate SE 1.5 Stearyl alcohol 1.5 lanolin 1.5 Polysorbate 60 1.3 Sorbitan stearate 0.5 Hydrogenated vegetable oil 1.0 Mineral oil 5.0 Squalane 3.0 Trioctanoine 2.0 Dimethicone 0.8 Tocopherol acetate 0.5 Carboxyvinyl polymer 0.12 glycerin 5.0 1.3-butylene glycol 3.0 Sodium hyaluronate 5.0 Triethanolamine 0.12 Methylparaben 0.2 incense 0.02 Distilled water Balance Sum 100

Formulation example 3: nourishing cream

Examples of the prescription of nutritional cream among cosmetics containing fermented corn beard liquid are as follows.

ingredient Content (% by weight) Corn beard fermentation broth 3.0 Lipotype glycerin monostearate 2.0 Cetearyl alcohol 2.2 Stearic acid 1.5 Beeswax 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Hydrogenated vegetable oil 1.0 Squalane 3.0 Mineral oil 5.0 Trioctanoine 5.0 Dimethicone 1.0 Sodium magnesium silicate 0.1 glycerin 5.0 Betaine 3.0 Triethanolamine 1.0 Sodium hyaluronate 4.0 Methylparaben 0.2 incense 0.05 Distilled water Balance Sum 100

Experimental example 3: Cosmetic Whitening effect experiment of composition

A whitening effect test of the cosmetic composition of the present invention was conducted on 40 Korean women, especially those aged 20-40, with dark skin. As prescribed in Formulation Example 3, a product containing 3% corn beard yeast fermentation broth (Example 1) and a product containing 3% corn beard lactic acid bacteria fermentation broth (Example 2) were prepared, and Comparative Example 1 contains no corn beard fermentation broth. It was prepared, and as Comparative Example 2, a product containing 3% corn beard extract was prepared. In the experiment, a control product and a product containing fermented corn beard yeast were used on both sides of each face to 20 subjects, and 20 subjects used the comparison product and the product containing the fermented corn beard lactic acid bacteria to each of 20 subjects. Both sides of were used. Minolta CR 300 was used as a measuring device and was measured for 8 weeks. The experimental results were compared with the L value taken at week 8 with the L value taken at week 0, and the results are shown in Table 8 below.

division Comparative Example 1 Comparative Example 2 Example 1 Example 2 L value 0.125 0.235 0.453 0.468

As shown in Table 6, the products (Examples 1 and 2) containing the fermentation broth of corn beard showed higher whitening effect compared to Comparative Example 1 that did not contain the corn beard extract. In addition, it exhibited a significantly higher whitening effect compared to Comparative Example 2 containing the corn beard extract. That is, it can be seen that the whitening effect is increased by fermenting the corn beard extract having whitening activity. Therefore, it can be seen that the cosmetic composition of the present invention has a very excellent whitening effect.

As described above, specific parts of the present invention have been described in detail, and it is obvious that these specific techniques are only preferred embodiments, and the scope of the present invention is not limited thereto for those of ordinary skill in the art. Accordingly, it will be said that the substantial scope of the present invention is defined by the appended claims and their equivalents.

Claims (5)

A cosmetic composition for skin whitening comprising a fermented corn beard obtained by culturing corn beard with Bifidobacterium. The cosmetic composition for skin whitening according to claim 1, wherein the fermented corn beard liquid is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition for skin whitening according to claim 1, wherein the fermented corn beard broth inhibits melanin production and inhibits tyrosinase activity. The method of claim 1, wherein the cosmetic composition is composed of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleansing, an oil, a powder foundation, an emulsion foundation, a wax foundation, and a spray. A cosmetic composition for skin whitening, characterized in that it has a formulation selected from the group. delete