CN104814901A - Striae gravidarum preventing gel and preparation method thereof - Google Patents
Striae gravidarum preventing gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses striae gravidarum preventing gel. The striae gravidarum preventing gel comprises the following ingredients: purified water, an antiseptic substance, gel, polyalcohol, sodium alginate, hydroxyethyl cellulose, deep-sea gadus skin collagen protein, alkali liquor, beta-glucan, water soluble ceramide and centella extract. The invention also discloses a preparation method of the striae gravidarum preventing gel. The striae gravidarum preventing gel has good affinity with peripheral tissues of skin and can promote production of skin flbroblast collagen and hyaluronic acid, repair skin tissues, promote metabolism of the skin and improve skin elasticity, so that skin moistening, scleroderma softening, skin neogenesis promoting, skin cornification retarding and pore minimizing aims are realized.
Description
Technical field
The invention belongs to cosmetic technical field, particularly one prevention striae gravidarum gel and preparation method thereof.
Background technology
Now, along with the continuous lifting of living standard, increasing female friend pays close attention to oneself appearance bearing, but puerperal, striae gravidarum but became the problem perplexing a lot of women.
Striae gravidarum is a kind of striae distensae.At phenolics, on the one hand, due to the acute variation of hormone secretion, cause the flexibility decrease of skin, make the elastic fiber under skin produce Damage and Fracture; On the other hand, along with the expansion in uterus increases, abdominal part protuberance causes muscle to elongate, and thinning of skin attenuates, and irregular aubergine decorative pattern appears in stomach wall.By the time after childbirth terminates, these decorative pattern decorative patterns fade away, and leaving the cicatrix line-transect stricture of vagina of white, is exactly striae gravidarum.
The generation of striae gravidarum is subject to the impact of many factors, and many factors all can affect the emergence and development of striae gravidarum, such as age factor, individual variation, diet aspect and normal some cosmetics used.But existing for preventing the massage products of striae gravidarum or being exactly Fructus Canarii albi wet goods oily matter, in the process used, there is inconvenience, easy pollution clothes; May to the influential material of baby containing artificial color or essence etc.; Price is very expensive, can not meet the long-term needs of numerous female friends.Therefore, need to find one effectively simple, moderate product solves the problem perplexing a lot of women.
Summary of the invention
Problem to be solved by this invention is to provide a kind of safe and harmless, and Costco Wholesale is cheap, and manufacturing process is gel preventing striae gravidarum and preparation method thereof simply.
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 45.00%-96.00%
Antiseptic: 0.00%-3.00%
Gel: 0.01%-3.00%
Polyhydric alcohol: 1.00%-20.00%
Sodium alginate: 0.20%-10.00%
Hydroxyethyl-cellulose: 0.01%-15.00%
Deep-sea cod collagen: 0.05%-15.00%
Alkali liquor: 0.10%-3.00%
Beta glucan: 0.10%-20.00%
Water solublity ceramide: 0.10%-10.00%
Herba Centellae extract: 0.01%-10.00%
Allantoin: 0.05%-5.00%
Glycyrrhizic acid dipotassium: 0.01%-8.00%
Hyaluronate sodium: 0.01%-5.00%
Preferably, described antiseptic is one or more the mixture in methyl hydroxybenzoate, propylparaben, Methylisothiazolinone and diazonium imidazolidinyl urea.
Preferably, described gel is the one in acrylate, carbomer and xanthan gum.
Preferably, described polyhydric alcohol is the one in 1,3 butylene glycol, propylene glycol and glycerol.
Preferably, described alkali liquor is the one in triethanolamine and 5% sodium hydroxide solution.
Prevent a preparation method for striae gravidarum gel, comprise the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, polyhydric alcohol, gel, antiseptic mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add alkali liquor and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Preferably, described hydroxyethyl-cellulose adopts particle diameter to be less than 40 object hydroxyethyl-cellulose powder.
Preferably, described Herba Centellae extract adopts water solublity Herba Centellae extract.
Preferably, described purified water adopts water purification equipment to obtain, and water purification equipment adopts ultraviolet sterilization and pasteurization to carry out disinfection when obtained described purified water.
Purified water is the water of the hyoscine that drinking water obtains through the way of distillation, ion exchange, hyperfiltration or other suitable methods, not containing any additive.Water purification equipment is the equipment producing purified water for meeting every profession and trade demand, be used for the industries such as medicine, biochemistry chemical industry, hospital, whole system is all combined by SUS304L or SUS316L all steel material, and whole system adopts ultraviolet sterilization or pasteurization, antibacterial when making purified water is eliminated, ensures the sanitation degree of purified water.
Polyhydric alcohol is the alcohols containing more than three or three hydroxyls in molecule.Adopt the one in 1,3 butylene glycol, propylene glycol and glycerol in the present invention, it has polar substances solvability strong, and toxicity and the characteristic such as volatility is little, have good hygroscopicity and bactericidal action, has no stimulation to the mucosa of human body and skin.
Sodium alginate is a kind of natural polysaccharide, there is the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and safety, the suspension of various medicine is beneficial in the present invention, and energy can effectively improve skin-nourishing, improve epithelial tissue healthy growth, prevent xerosis cutis, make skin be rich in gloss, improve fat secretion, careful pore.
Hydroxyethyl-cellulose is a kind of white or faint yellow, and tasteless, nontoxic threadiness or pulverulent solids are prepared through etherification reaction by alkali cellulose and oxirane (or 2-chloroethyl alcohol), belongs to nonionic soluble fiber element ethers.Complement each other to form the atherosclerotic thing do not allowed in the present invention with polyhydric alcohol, there is good moisture retention and water absorption, can ensure that skin obtains sufficient moisture, ensure the vigor of cell.
Collagen protein is extracted by animal skins, can be spread to the deep layer of skin, tyrosine in its tyrosine contained and skin is competed, and be combined with the catalytic center of tryrosinase, thus the generation of check melanin, make the collagen protein increased activity in skin, keep the integrity of horny layer moisture and fibre structure, improve the living environment of Skin Cell, promote the metabolism of skin histology, and for the circulation of blood, there is certain reinforced effects, good moist moisturizing, effect wrinkles eliminating vanishing effect are produced to skin.Deep-sea cod collagen is from the morrhua in deep-sea, and the range of activity of the principle mankind, the pollutant component in its fish skin is less, less on the impact of skin when being used as medicine.
Beta glucan is a kind of new product with unique process exploitation, and it derives from fresh food beer yeast, Herba bromi japonici, edible fungi etc.It is a kind of polysaccharide, general chemical structure β-1,3 glucosans and β-1,6 glucosans, assist damaged tissues to produce cytokines as histiocyte adds quick-recovery, impel and comprise antibiotic, antifungal, anti-parasitic medicine is played effectiveness better at interior other drug, can accelerate the performance of other composition drug effects.
Water solublity ceramide water solublity ceramide, have another name called ceramide, be a kind of water-soluble grease metallic substance, it is close with the structure of matter forming keratodermatitis, can penetrate into skin very soon, combine with the water in horny layer, form a kind of network structure, pin moisture, there is the ability of active cell, promote the metabolism of cell, impel the regular regeneration of keratoprotein.
Herba Centellae extract Herba Centellae can be compacted epidermis and corium coupling part, and skin can be made to limber up, and contributes to solving cutis laxa phenomenon, makes skin smooth flexible; Help to promote that collagen protein is formed in skin corium, makes fibrin regenerate, reconnects, fundamentally eliminate striae gravidarum, skin is reached compact smooth effect.Also can help impaired organization healing and consolidation skin.Can to promote between epidermis with corium close is connected, the increase of adipose cell can be suppressed again, prevent hydroderma, occur fat.To compact epidermis and corium coupling part, skin can be made to limber up, help to promote that in skin corium, collagen protein is formed, and has the effect making skin compact.The present invention adopts water solublity Herba Centellae extract to be convenient to it to spread in gel evenly, and the assimilation effect of skin is better.
Allantoin is a kind of amphoteric compound, can form double salt, have lucifuge, sterilization and anticorrosion, pain relieving, antioxidation in conjunction with many kinds of substance, and skin can be made to keep moisture content, moist and soft.
Glycyrrhizic acid dipotassium be white or off-white color fine powder, purity reaches 98%, has special sweet taste, water-soluble good, mouthfeel is pure.Glycyrrhizic acid dipotassium has the multiple efficacies such as antibacterial, antiinflammatory, removing toxic substances, antiallergic, deodorization.Glycyrrhizic acid diformazan and other components matching use in the present invention, can accelerate the absorption of other composition, and have and regulate the effect of sebum, for striae gravidarum prevention and eliminate very effective.
Hyaluronate sodium is white or off-white color granule or powder; odorless; be one of formation of human body skin, be the widest glutinous sugar of one acidity of people's distribution in vivo, be present in the substrate of connective tissue; there is good moisture-keeping function; skin moisturizing can be kept smooth, fine and smooth tender, high resilience; there is the effect of wrinkle resistant, crease-resistant, aesthetic health care and recovery skin physiology function, prevent the generation of chapped skin and wrinkle.
Above-mentionedly made explanation to the pharmacology of each composition and the effect of performance, what each component of the present invention was particular about is mutual synergism, reaches following effect:
1. with the affinity good Neng Cu Walk-reverently skin fibroblast collagen of skin surrounding tissue and hyaluronic production, repairing skin tissue, promote the metabolism of skin, and improve skin elasticity, thus realize skin care, softening sclerderm, promote skin revitalization, slow down skin keratin, the object of careful pore;
2. affinity is strong, can combine together, form the natural barrier of one deck, and promote the propagation of skin base cell at skin surface, have obvious physiologic effect to delay skin aging, careful pore with the sebum film of mankind itself;
3. can effectively improve skin-nourishing, improve epithelial tissue healthy growth, prevent xerosis cutis, make skin be rich in gloss, improve fat secretion, careful pore;
4. formula rationally, environmental protection, to no skin irritation, life-time service can supplement skin-nourishing, careful pore, makes skin wet flexible.
The effect being prevention and treating that inventive gel plays for striae gravidarum, different from the medicine of traditional treatment striae gravidarum, general medicine is that after anemia of pregnant woman produces, striae gravidarum formation starts to smear medicine, then after smearing a period of time continuously, striae gravidarum starts slowly to eliminate, the required time is longer, be generally between 3 months to 12 months, although also can play the effect for the treatment of to striae gravidarum, but anemia of pregnant woman wants after producing cannot accomplish putting on refrigerant summer clothing within these few days, the overlong time of striae gravidarum treatment has had a strong impact on effect and the meaning of its treatment.Inventive gel can use at anemia of pregnant woman's phenolics, impact be there is no on fetus, can in use after conceived three months of anemia of pregnant woman, pregnancy is got appropriate inventive gel for 3 to 6 months and is smeared to abdominal part, buttocks and huckle, and carry out stroking 2 to 5 minutes, make inventive gel uniform application on skin, play good absorption to drug effect, frequency of utilization once a day; Conceived 6 to October gets appropriate inventive gel and smears to abdominal part, buttocks and huckle, and carries out stroking 2 to 5 minutes, and frequency of utilization twice daily; Anemia of pregnant woman gets appropriate inventive gel and smears to abdominal part, buttocks and huckle after producing, and carries out massage 5 to 10 minutes, frequency of utilization every day three times.Through test repeatedly prove to use inventive gel striae gravidarum two weeks internal therapy thoroughly probability can reach 85%, the rehabilitation probability in three months puerperal is 100%.Inventive gel is all very effective for the anemia of pregnant woman of Different age group, in the anemia of pregnant woman one month of 20 years old to 35 years old, rehabilitation probability is 100%, in anemia of pregnant woman's striae gravidarum one month of more than 35 years old, rehabilitation probability reaches 90%, the patient that striae gravidarum was not fully recovered in one month continues to use the present invention, all cures within three months puerperal.
The service condition of inventive gel is as follows:
| Pregnant woman age section | Two weeks recovery from illness in puerperal probability | Recovery from illness in one month puerperal probability | Recovery from illness in three months puerperal probability |
| 20 to 35 years old | 90% | 100% | 100% |
| More than 35 years old | 70% | 90% | 100% |
Detailed description of the invention
Embodiment one
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 86.05%; Methyl hydroxybenzoate: 0.1%; Carbomer: 0.3%; Glycerol: 10%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.25%; Triethanolamine: 0.3%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, carbomer, methyl hydroxybenzoate mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment two
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 80%; Propylparaben: 0.2%; Carbomer: 0.2%; Propylene glycol: 16.05%; Sodium alginate: 0.3%; Hydroxyethyl-cellulose: 0.6%; Deep-sea cod collagen: 0.25%; Triethanolamine: 0.3%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.3%; Glycyrrhizic acid dipotassium: 0.3%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, propylene glycol, carbomer, propylparaben mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment three
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 86%; Methyl hydroxybenzoate: 0.2%; Acrylate: 0.35%; Glycerol: 10%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.45%; Deep-sea cod collagen: 0.25%; 5% sodium hydroxide solution: 0.3%; Beta glucan: 0.4%; Water solublity ceramide: 0.4%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.45%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, acrylate, methyl hydroxybenzoate mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add 5% sodium hydroxide solution and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment four
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 84%; Methyl hydroxybenzoate: 0.15%; Xanthan gum: 0.3%; 1,3 butylene glycol: 12%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.35%; Triethanolamine: 0.2%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.38%; Hyaluronate sodium: 0.12%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) by the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, 1, join in 40-50 DEG C of purified water after 3-butanediol, xanthan gum, methyl hydroxybenzoate mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment five
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 87%; Propylparaben: 0.1%; Carbomer: 0.3%; 1,3 butylene glycol: 9.05%; Sodium alginate: 0.3%; Hydroxyethyl-cellulose: 0.6%; Deep-sea cod collagen: 0.25%; Triethanolamine: 0.3%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 0.9%; Allantoin: 0.3%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) by the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, 1, join in 40-50 DEG C of purified water after 3-butanediol, carbomer, propylparaben mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment six
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 80%; Propylparaben: 0.15%; Acrylate: 0.3%; 1,3 butylene glycol: 16%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.2%; 5% sodium hydroxide solution: 0.35%; Beta glucan: 0.3%; Water solublity ceramide: 0.6%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) by the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, 1, join in 40-50 DEG C of purified water after 3-butanediol, acrylate, propylparaben mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add 5% sodium hydroxide solution and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment seven
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 82%; Methylisothiazolinone: 0.1%; Carbomer: 0.35%; Glycerol: 14%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.25%; Triethanolamine: 0.35%; Beta glucan: 0.35%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.4%; Glycyrrhizic acid dipotassium: 0.2%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, carbomer, Methylisothiazolinone mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment eight
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 88%; Diazonium imidazolidinyl urea: 0.1%; Carbomer: 0.35%; Glycerol: 8%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.25%; 5% sodium hydroxide solution: 0.4%; Beta glucan: 0.25%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.05%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) join in 40-50 DEG C of purified water by after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, carbomer, diazonium imidazolidinyl urea mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add 5% sodium hydroxide solution and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment nine
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 86%; Methyl hydroxybenzoate: 0.05%; Propylparaben: 0.05%; Carbomer: 0.3%; Glycerol: 10%; Sodium alginate: 0.4%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.3%; Triethanolamine: 0.3%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, carbomer, methyl hydroxybenzoate, propylparaben mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment ten
A kind of prevention striae gravidarum gel, the percentage by weight of its composition and each composition is as follows:
Purified water: 87%; Methylisothiazolinone: 0.05%; Diazonium imidazolidinyl urea: 0.05%; Acrylate: 0.3%; Glycerol: 9%; Sodium alginate: 0.45%; Hydroxyethyl-cellulose: 0.5%; Deep-sea cod collagen: 0.15%; Triethanolamine: 0.4%; Beta glucan: 0.4%; Water solublity ceramide: 0.5%; Herba Centellae extract: 1.0%; Allantoin: 0.2%; Glycyrrhizic acid dipotassium: 0.4%; Hyaluronate sodium: 0.1%.
Its preparation method comprises the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) join in 40-50 DEG C of purified water by after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, glycerol, acrylate, Methylisothiazolinone, diazonium imidazolidinyl urea mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add triethanolamine and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
Embodiment one is gels of different formulations and weight ratio to embodiment ten, in treatment striae gravidarum process, each embodiment treatment number of patients is 80 patients, within 20 to 35 years old, anemia of pregnant woman's quantity is 60 people, and more than 35 years old anemia of pregnant woman quantity of fully recovering is 20 people, and the effect of curing number is as shown in the table:
The effect of embodiment one is best as seen from the above table, number of fully recovering in 20 to 35 years old anemia of pregnant woman's striae gravidarum two weeks is 54 people, can fully recover in one month, in more than 35 years old anemia of pregnant woman's striae gravidarum two weeks, recovery from illness number is 14 people, number of fully recovering in one month is 18 people, can fully recover in three months, the speed for the treatment of and there is very high healing success rate.
The present invention uses extensively, be no matter that anemia of pregnant woman's striae gravidarum at much ages can be accomplished very to fully recover, and the time for the treatment of is shorter, can reply vigor and the elasticity of skin within the extremely short time.And inventive gel has no side effect, in use not there is anaphylaxis in 800 anemia of pregnant woman of ten embodiments, and does not impact neonate, illustrates that inventive gel is non-stimulated to skin mucosa, bad impact can not be caused on offspring, be applicable to promoting the use of.
Inventive gel treatment case is clinically as follows:
Case one: Xiong Xuehui, female, 33 years old, people from Nanyang City, Henan Province, conceived rising for three months brings into use inventive gel, natural labor, abdominal part and the pregnant stricture of vagina of being pregnent of buttocks not obvious, continue use the 22nd day striae gravidarum after producing son and eliminate, skin is repaired completely.
Case two: Li Meng, female, 24 years old, people from Nanyang City, Henan Province, conceived rising for three months brought into use inventive gel, natural labor, and abdominal part has striae gravidarum not obvious, and continue use the 12nd day striae gravidarum after producing son and eliminate, skin is repaired completely.
Case three: Wang Yiyi, female, 28 years old, people from Xinyang City, Henan Province, conceived rising for three months brought into use inventive gel, natural labor, and abdominal part has striae gravidarum not obvious, and continue use the 14th day striae gravidarum after producing son and eliminate, skin is repaired completely.
Case four: Gong Yanxiao, female, 40 years old, people from Nanyang City, Henan Province, conceived rising for three months brings into use inventive gel, natural labor, and abdominal pregnancy stricture of vagina is comparatively obvious, buttocks and thigh striae gravidarum not obvious, continue use the 57th day striae gravidarum after producing son and eliminate, skin is repaired completely.
Claims (9)
1. prevent a striae gravidarum gel, it is characterized in that: the percentage by weight of its composition and each composition is as follows:
Purified water: 45.00%-96.00%
Antiseptic: 0.00%-3.00%
Gel: 0.01%-3.00%
Polyhydric alcohol: 1.00%-20.00%
Sodium alginate: 0.20%-10.00%
Hydroxyethyl-cellulose: 0.01%-15.00%
Deep-sea cod collagen: 0.05%-15.00%
Alkali liquor: 0.10%-3.00%
Beta glucan: 0.10%-20.00%
Water solublity ceramide: 0.10%-10.00%
Herba Centellae extract: 0.01%-10.00%
Allantoin: 0.05%-5.00%
Glycyrrhizic acid dipotassium: 0.01%-8.00%
Hyaluronate sodium: 0.01%-5.00%.
2. prevention striae gravidarum gel as claimed in claim 1, is characterized in that: described antiseptic is one or more the mixture in methyl hydroxybenzoate, propylparaben, Methylisothiazolinone and diazonium imidazolidinyl urea.
3. prevention striae gravidarum gel as claimed in claim 1, is characterized in that: described gel is the one in acrylate, carbomer and xanthan gum.
4. prevention striae gravidarum gel as claimed in claim 1, is characterized in that: described polyhydric alcohol is the one in 1,3 butylene glycol, propylene glycol and glycerol.
5. prevention striae gravidarum gel as claimed in claim 1, is characterized in that: described alkali liquor is the one in triethanolamine and 5% sodium hydroxide solution.
6. prevent a preparation method for striae gravidarum gel, it is characterized in that: comprise the steps:
(1) each component is taken according to the percentage by weight of specifying;
(2) will join in 40-50 DEG C of purified water after the hyaluronate sodium of formula ratio, glycyrrhizic acid dipotassium, allantoin, deep-sea cod collagen, hydroxyethyl-cellulose, sodium alginate, polyhydric alcohol, gel, antiseptic mix homogeneously, be heated to 75-80 DEG C of insulation 10-15 minute while stirring, make each material dispersion even;
(3) reduce temperature to 35-40 DEG C, add the Herba Centellae extract of formula ratio, water solublity ceramide and beta glucan, be uniformly mixed;
(4) finally add alkali liquor and regulate pH, ensure that temperature stirs at 35-40 DEG C and make mix homogeneously, obtain described prevention striae gravidarum gel.
7. the preparation method of prevention striae gravidarum gel as claimed in claim 6, is characterized in that: described hydroxyethyl-cellulose adopts particle diameter to be less than 40 object hydroxyethyl-cellulose powder.
8. the preparation method of prevention striae gravidarum gel as claimed in claim 6, is characterized in that: described Herba Centellae extract adopts water solublity Herba Centellae extract.
9. the preparation method of prevention striae gravidarum gel as claimed in claim 6, is characterized in that: described purified water adopts water purification equipment to obtain, and water purification equipment adopts ultraviolet sterilization and pasteurization to carry out disinfection when obtained described purified water.
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| CN106511131A (en) * | 2016-11-28 | 2017-03-22 | 丁慧 | Moisturizing water capable of adjusting bioactivity of cuticle desmosome and preparation method thereof |
| CN109125173A (en) * | 2018-09-19 | 2019-01-04 | 李燕 | A kind of face cream and preparation method thereof removing striae of pregnancy |
| CN110314127A (en) * | 2019-08-23 | 2019-10-11 | 杭州千岛湖蓝色天使实业有限公司 | One kind is dispelled striae of pregnancy essence cream and preparation method thereof |
| CN112006938A (en) * | 2020-09-04 | 2020-12-01 | 广州莱梧生物科技有限公司 | Damaged skin repairing gel and preparation process thereof |
| CN112107504A (en) * | 2020-09-24 | 2020-12-22 | 成都维德医疗器械有限责任公司 | Preparation method of modified type I collagen gel |
| CN115670992A (en) * | 2022-09-06 | 2023-02-03 | 南京天其美生物技术有限公司 | Herbal peritoneal membrane for gestation repair and preparation method thereof |
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| US20040208902A1 (en) * | 2003-04-18 | 2004-10-21 | Gupta Shyam K. | Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511131A (en) * | 2016-11-28 | 2017-03-22 | 丁慧 | Moisturizing water capable of adjusting bioactivity of cuticle desmosome and preparation method thereof |
| CN109125173A (en) * | 2018-09-19 | 2019-01-04 | 李燕 | A kind of face cream and preparation method thereof removing striae of pregnancy |
| CN110314127A (en) * | 2019-08-23 | 2019-10-11 | 杭州千岛湖蓝色天使实业有限公司 | One kind is dispelled striae of pregnancy essence cream and preparation method thereof |
| CN110314127B (en) * | 2019-08-23 | 2022-06-21 | 杭州千岛湖蓝色天使实业有限公司 | Stretch mark removing essence lotion and preparation method thereof |
| CN112006938A (en) * | 2020-09-04 | 2020-12-01 | 广州莱梧生物科技有限公司 | Damaged skin repairing gel and preparation process thereof |
| CN112107504A (en) * | 2020-09-24 | 2020-12-22 | 成都维德医疗器械有限责任公司 | Preparation method of modified type I collagen gel |
| CN115670992A (en) * | 2022-09-06 | 2023-02-03 | 南京天其美生物技术有限公司 | Herbal peritoneal membrane for gestation repair and preparation method thereof |
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| CN104814901B (en) | 2017-10-24 |
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Address after: 473000 Nanyang City, new energy economic and Technological Development Zone, Henan, the middle of the road in the middle of the ten Applicant after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Applicant before: Nanyang Hui Bo Bioisystech Co., Ltd |
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