CN112754981A - Collagen regeneration promoting preparation and preparation method and application thereof - Google Patents
Collagen regeneration promoting preparation and preparation method and application thereof Download PDFInfo
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- CN112754981A CN112754981A CN202011615832.6A CN202011615832A CN112754981A CN 112754981 A CN112754981 A CN 112754981A CN 202011615832 A CN202011615832 A CN 202011615832A CN 112754981 A CN112754981 A CN 112754981A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention belongs to the technical field of cosmetics, and discloses a preparation for promoting collagen regeneration and a preparation method and application thereof. The preparation is prepared by adopting glucan polypeptide with good biodegradability, activated macrophages and secreted transforming growth factors, is used for supplementing raw materials of various proteins, collagen and plant cellulose for compatibility, and is further added with the functions of diminishing inflammation, resisting infection and stimulating the interaction and mutual fusion of active ingredients of various natural plant extracts for continuously regenerating the collagen, so that the tissue is repaired, the oxidation of facial skin is deeply resisted, the regeneration of the collagen at the muscle bottom is promoted, the metabolism is promoted, the wrinkles of the skin are stretched, the density of the skin is improved, the tension is generated, and the facial skin is more elastic, compact, smooth and bright. The preparation is natural, safe and mild, and has simple preparation process, easy operation, and convenient mass production.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a preparation for promoting collagen regeneration and a preparation method and application thereof.
Background
The skin is the largest organ of the human body and is the natural barrier between the body and the outside. The composition and structure of the skin are highly complex, including various biological macromolecules such as cells, elastic fibers, collagen peptide powder, proteoglycan and the like, and small molecules such as glucose, amino acids, inorganic salts, vitamins and the like.
The skin of the human body is composed of four parts, namely epidermis, basement membrane, dermis and subcutaneous tissue. Clinically, trauma, ulcer, inflammation, burn, operation, congenital deformity, skin defect and abnormality such as skin pit or pockmark, acne mark and the like caused by environmental factors not only cause the pain of the body of a patient, but also often cause the heart injury.
In order to solve physiological and psychological pains of human beings caused by skin damage, tissue aging, etc., attempts have been made in recent years to use collagen, etc., as a repair material for skin, bone tissue, etc., to alleviate symptoms and promote regeneration of tissues and cells.
In the prior art, human-like blood protein is used as a raw material, various polypeptide products and various chemical raw material preparations are used as auxiliary materials for products used in the medical and beauty industry, the raw materials added in the preparation process of the products are numerous, the dosage of the raw materials is complicated, the step flow is more, and meanwhile, the products cannot be metabolized after being used by a user and are continuously left in the body, so that secondary injury is caused.
Disclosure of Invention
In order to solve the above problems in the prior art, the present invention aims to provide a collagen regeneration promoting preparation, a preparation method and an application thereof.
The technical scheme adopted by the invention is as follows: a preparation for promoting collagen regeneration is mainly prepared from the following raw materials in parts by mass:
600 parts of glucan polypeptide, 300 parts of collagen peptide powder, 300 parts of sheep embryo extract, 30-100 parts of amino acid, 20-80 parts of sodium hyaluronate, 100 parts of corn extract, 180 parts of red ginseng extract, 100 parts of acerola cherry powder and 180 parts of green tea extract.
Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:
540 parts of glucan polypeptide, 120 parts of collagen peptide powder, 220 parts of sheep embryo extract, 30-70 parts of amino acid, 60-110 parts of sodium hyaluronate, 170 parts of corn extract, 120 parts of red ginseng extract, 170 parts of acerola cherry powder and 170 parts of green tea extract.
Preferably, the preparation is mainly prepared from the following raw materials in parts by mass:
480 parts of glucan polypeptide, 150 parts of collagen peptide powder, 65 parts of sheep embryo extract, 50 parts of amino acid, 70 parts of sodium hyaluronate, 145 parts of corn extract, 135 parts of red ginseng extract, 120 parts of acerola powder and 145 parts of green tea extract.
The collagen peptide powder is a fiber composition mainly containing collagen, and amino acids such as glycine, proline and hydroxyproline. The biochemical component of the collagen peptide powder is type I collagen. Collagen (collagen) is secreted by fibroblasts, and is polymerized extracellularly into collagen fibrils, which are then bonded to collagen peptide powder in small quantities.
The placenta extract contains mainly protein, nucleic acid, phospholipids, polysaccharide, amino acids, minerals, vitamins, etc. and its essence is small molecular peptide matter and nucleic acid segment as well as essential element for activating cell.
Sodium hyaluronate is a polysaccharide substance. Generally, proteins are bound together in the connective tissue of the skin, and together with chondroitin sulfate, they fill the intercellular spaces, and play a good role in maintaining tissue moisture, lubricity, softness, and tissue structure, and preventing the entry of bacteria. It has hygroscopic property. Insoluble in organic solvent, soluble in water, and has high viscosity. The product is water soluble and has no greasy feeling, and the sugar chain is linear and has random crimp state. Has good viscoelasticity, plasticity, permeability and biocompatibility. Coexisting with other hyaluronic acids, causes hydrolysis of glycosidic bonds in the molecule, or intermolecular depolymerization in the presence of reducing substances and irradiation with light (ultraviolet rays, electron beam radiation). Hyaluronic Acid (HA) is widely used in cosmetic medicine due to its binding ability to a large number of water molecules. It can improve tissue hydration and resist mechanical damage. HA plays an important role in wound healing, ovulation, fertilization, signal transduction and tumor physiology. HA is used in joint diseases such as osteoarthritis or rheumatoid arthritis. High molecular weight HA reduces chemotaxis and migration of inflammatory cells, which acts as a good barrier to inflammatory processes and protects against free radicals. HA is used in ophthalmology due to its lubricating properties on the corneal endothelium, and improves tissue hydration and cell resistance to mechanical damage in aesthetic dermatology, with marginal side effects. Several tests have shown their role in tumor markers, liver disease and drugs. Hyaluronic acid plays an important role in cancer growth and metastasis.
Ginseng radix Rubri extract containing anticancer ginsenoside Rh2It is used to reduce the generation of active oxygen free radicals in vivo, resist aging and enhance immunity.
The green tea extract is helpful for delaying aging, and the tea polyphenol has strong oxidation resistance and physiological activity and is a scavenger of free radicals of a human body. Tea polyphenols have effects of blocking lipid peroxidation and removing active enzyme. According to the results of Japanese Australian brave experiment, the anti-aging effect of tea polyphenol is proved to be 18 times stronger than that of vitamin E. Astringe pores, and has effects of sterilizing, resisting skin aging, and reducing skin injury caused by ultraviolet radiation in sunlight.
Preferably, the formulation is a liquid formulation.
A preparation method of a collagen regeneration promoting preparation comprises the steps of correspondingly selecting glucan polypeptide, collagen peptide powder, a sheep placenta extract, amino acid, sodium hyaluronate, a corn extract, a red ginseng extract, acerola cherry powder and a green tea extract, adding an emollient, a penetrating agent and a solvent, uniformly mixing, and filtering to obtain a finished product.
Preferably, the emollient comprises one or more of kumquat extract, blueberry extract and raspberry extract.
The cumquat extract cumquat fruit contains rich vitamin A, and can prevent pigmentation, improve skin luster and elasticity, slow aging and avoid skin relaxation and wrinkles. It can also be used for preventing civilized diseases such as angiopathy and cancer, regulating qi-flowing, relieving cough, invigorating stomach, eliminating phlegm, and preventing asthma and bronchitis. Kumquat also contains vitamin P, is an important nutrient for maintaining the health of blood vessels, can strengthen the elasticity of micro blood vessels, and can be used as an auxiliary nursing food for hypertension, angiosclerosis and heart diseases. 80% of vitamin C in kumquat is stored in the pericarp, which has the efficacy of detoxification function of liver, eye care and health care of immune system, and the pericarp of kumquat is sweeter than pulp.
Preferably, the osmotic agent comprises an extract of Equisetum arvense.
Equisetum arvense has medical value. The plant stem contains a large amount of silicone and silicic acid, which contribute to repair of bone fractures and formation of collagen, which are important proteins present in connective tissues, skin, bones, cartilage and ligaments. The whole herb contains equisetum arvense saponin, equisetum glycoside, isoquercitrin, luteolin, silicic acid (the content of silicic acid is 5.19-7.77% of dry crude drugs), organic acid, fat, beta-sitosterol, equisetum arvense alkali, dimethyl sulfone, thymine, 3-methoxypyridine and various amino acids. The spore contains pentahydroxy anthraquinone glucoside, octacosanedioic acid, triacontanedioic acid, dimethyl triacontanedioic acid, hypodermoside and gossypin.
Preferably, the solvent comprises deionized water.
Preferably, the ratio of the total dosage of the glucan polypeptide, the collagen peptide powder, the sheep placenta extract, the amino acid, the sodium hyaluronate, the corn extract, the red ginseng extract, the acerola cherry powder and the green tea extract to the dosage of the emollient, the penetrant and the solvent is 10-30:3-5:6-8: 30-70.
Use of a collagen regeneration promoting preparation according to any one of claims 1 to 3 in a cosmetic product.
The invention has the beneficial effects that:
the invention provides a preparation for promoting collagen regeneration, which is prepared by adopting glucan polypeptide with good biodegradability, activated macrophages and secreted transforming growth factors, is used for supplementing raw materials of various proteins, collagen and plant cellulose, and is added with the functions of diminishing inflammation, resisting infection and stimulating the interaction and mutual fusion of active ingredients of various natural plant extracts for continuously regenerating the collagen, so that the effects of repairing tissues, deeply resisting the oxidation of facial skin, promoting the regeneration of the collagen at the muscle bottom, promoting the metabolism, stretching skin wrinkles, improving skin density and generating tension are achieved, and the facial skin is more elastic, compact, smooth and glossy. The preparation is natural, safe and mild, and has simple preparation process, easy operation, and convenient mass production.
Detailed Description
The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples were carried out under the conventional conditions, unless otherwise specified. The reagents used are all conventional products which are commercially available.
Example 1:
a preparation method of a preparation for promoting collagen regeneration comprises the steps of correspondingly selecting 300 g of glucan polypeptide, 100 g of collagen peptide powder, 30 g of sheep embryo extract, 20 g of amino acid, 50 g of sodium hyaluronate, 100 g of corn extract, 100 g of red ginseng extract, 100 g of acerola cherry powder and 100 g of green tea extract, adding 270 g of kumquat extract, 540 g of field horsetail extract and 2700 g of deionized water, uniformly mixing, and filtering to obtain a finished product.
Example 2:
a preparation method of a collagen regeneration promoting preparation comprises the steps of correspondingly selecting 300 g of glucan polypeptide, 100 g of collagen peptide powder, 30 g of sheep embryo extract, 20 g of amino acid, 50 g of sodium hyaluronate, 100 g of corn extract, 100 g of red ginseng extract, 100 g of acerola cherry powder and 100 g of green tea extract, adding 150 g of blueberry extract, 240 g of field horsetail extract and 2100 g of deionized water, uniformly mixing, and filtering to obtain a finished product.
Example 3:
a preparation method of a preparation for promoting collagen regeneration comprises the steps of correspondingly selecting 600 g of glucan polypeptide, 300 g of collagen peptide powder, 100 g of sheep embryo extract, 80 g of amino acid, 150 g of sodium hyaluronate, 180 g of corn extract, 180 g of red ginseng extract, 180 g of acerola cherry powder and 180 g of green tea extract, adding 585 g of raspberry extract, 1170 g of field horsetail extract and 5850 g of deionized water, mixing uniformly, and filtering to obtain a finished product.
Example 4:
a preparation method of a preparation for promoting collagen regeneration comprises the steps of correspondingly selecting 320 g of glucan polypeptide, 120 g of collagen peptide powder, 40 g of sheep embryo extract, 30 g of amino acid, 60 g of sodium hyaluronate, 120 g of corn extract, 120 g of red ginseng extract, 120 g of acerola cherry powder and 120 g of green tea extract, adding 175 g of kumquat extract, 280 g of field horsetail extract and 2450 g of deionized water, mixing uniformly, and filtering to obtain a finished product.
Example 5:
a preparation method of a preparation for promoting collagen regeneration comprises the steps of correspondingly selecting 540 g of glucan polypeptide, 220 g of collagen peptide powder, 80 g of sheep placenta extract, 70 g of amino acid, 110 g of sodium hyaluronate, 170 g of corn extract, 170 g of red ginseng extract, 170 g of acerola cherry powder and 170 g of green tea extract, adding 260 g of kumquat extract, 250 g of blueberry extract, 1020 g of field horsetail extract and 5100 g of deionized water, mixing uniformly, and filtering to obtain a finished product.
Example 6:
a preparation method of a preparation for promoting collagen regeneration comprises the steps of correspondingly selecting 480 g of glucan polypeptide, 150 g of collagen peptide powder, 65 g of sheep embryo extract, 50 g of amino acid, 70 g of sodium hyaluronate, 145 g of corn extract, 135 g of red ginseng extract, 120 g of acerola cherry powder and 145 g of green tea extract, adding 150 g of kumquat extract, 120 g of blueberry extract, 138 g of raspberry extract, 816 g of field horsetail extract and 3173 g of deionized water, mixing uniformly, and filtering to obtain a finished product.
In the actual operation process of all the embodiments, the selected blending device comprises a three-dimensional motion mixer, stainless steel materials with specification models of SYH-30 and SYH-1000, and manufacturers: jiangyin and Rong mechanical Co. The selection of the stirring device is not limited to the above, and all devices which can complete the corresponding stirring work and have no influence on raw materials belong to the protection scope of the invention.
In the actual operation process of all the above embodiments, the selected filtering device comprises a filter press, which is made of stainless steel, and has the specification and model number: x (AM) G30/870-30U, manufacturer: shanghai Shangding machinery, Inc. The selection of the filtering device is not limited to the above, and all devices which can complete the corresponding filter pressing work and have no influence on the whole reaction belong to the protection scope of the invention.
In the actual operation process of all the embodiments, a high-temperature sterilization device is recommended to be selected for carrying out sterilization treatment on finished products, the high-temperature sterilization device comprises an ultrahigh-temperature instantaneous sterilizer which is made of stainless steel materials, and the specifications and the models are as follows: RP6L10, manufacturer: shanghai Taiwan light tools and equipments Ltd. The selection of the high-temperature sterilization device is not limited to the selection provided above, and all devices which can complete the corresponding high-temperature sterilization work and have no influence on the overall reaction belong to the protection scope of the invention.
Glucan polypeptide, manufacturer: guangzhou Lichen pharmaceutical Biotechnology, Inc., net contents: 7 g/mL.
Collagen peptide powder, manufacturer: jiangsu ancient shellfish biotechnology limited company, the content is more than or equal to 99 percent.
Sheep placenta extract, manufacturer: shanxi Teng mai Biotechnology Limited liability company, the content is more than or equal to 70%.
Amino acids, manufacturer: shandong Xinbaihe chemical technology Co., Ltd, the content is more than or equal to 38%.
Sodium hyaluronate, manufacturer: the content of the product is more than or equal to 99 percent by the biological technology limited of the Xian Ruien.
Corn extract, manufacturer: the content of the Xian Jinheng chemical industry Limited company is more than or equal to 30 percent.
Red ginseng extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Acerola cherry powder, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Green tea extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Kumquat extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Blueberry extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Raspberry extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Horsetail extract, manufacturer: shanxi Longzhou Biotech Co., Ltd., the content is more than or equal to 99%.
Deionized water, manufacturer: shenzhen, Baoan region, Tejiean environmental protection equipment factory, level: and 4, high-grade purity.
Examples of the experiments
The method comprises the steps of taking 70 white rabbits for biological experiments as experimental animals, constructing soft tissue injury around the radial joints of the right sides of the rabbits for the biological experiments by using the white rabbits for the biological experiments (the average month age is 6 months, the body weight is 3kg), constructing a skin injury notch on the corresponding skin surface, and excising 1.5cm of the radius from the middle section of the right side of the radius together with a periosteum to cause segmental bone defect.
The experimental animals were randomly divided into 10 groups of 10 animals, each group had 10 animals, 1-6 groups were applied to the corresponding lesions with the products prepared in examples 1-6, and 7 groups were applied with the control group selected from example 1 of CN 201710178736.1.
The detection mode is as follows: the regeneration and repair status was observed dissectively one week after the administration of the experimental group and the control group.
The detection result shows that 1-4 groups of segmental bone defects are filled with a large amount of fibrous tissues, and the bone defects are improved; the soft tissue injury around the right side radial joint is better, and the skin injury gap on the surface of the skin is basically healed.
The final products of examples 5 and 6 were significantly better than the other groups, with the two groups having a substantial healing of soft tissue injury, healing of skin injury gaps on the skin surface, and no visible gaps and scabs.
The above-described example products of the present application performed better than the control group, especially in the recovery of wounds on the skin surface.
The invention provides a preparation for promoting collagen regeneration, which is prepared by adopting glucan polypeptide with good biodegradability, activated macrophages and secreted transforming growth factors, is used for supplementing raw materials of various proteins, collagen and plant cellulose, and is added with the functions of diminishing inflammation, resisting infection and stimulating the interaction and mutual fusion of active ingredients of various natural plant extracts for continuously regenerating the collagen, so that the effects of repairing tissues, deeply resisting the oxidation of facial skin, promoting the regeneration of the collagen at the muscle bottom, promoting the metabolism, stretching skin wrinkles, improving skin density and generating tension are achieved, and the facial skin is more elastic, compact, smooth and glossy. The preparation is natural, safe and mild, and has simple preparation process, easy operation, and convenient mass production.
While particular embodiments of the present invention have been illustrated and described, it will be appreciated that the present invention is not limited to the above-described alternative embodiments, and that various other forms of product may be devised by anyone in light of the present invention. The foregoing detailed description should not be construed as limiting the scope of the invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the foregoing embodiments, or that equivalent substitutions may be made to some or all of the technical features thereof, without departing from the spirit and scope of the invention, and that these modifications or substitutions may not substantially depart from the essence of the corresponding technical solutions.
Claims (10)
1. The preparation for promoting collagen regeneration is characterized by being prepared from the following raw materials in parts by mass:
600 parts of glucan polypeptide, 300 parts of collagen peptide powder, 300 parts of sheep embryo extract, 30-100 parts of amino acid, 20-80 parts of sodium hyaluronate, 100 parts of corn extract, 180 parts of red ginseng extract, 100 parts of acerola cherry powder and 180 parts of green tea extract.
2. The preparation for promoting collagen regeneration according to claim 1, wherein the preparation is prepared from the following raw materials in parts by mass:
540 parts of glucan polypeptide, 120 parts of collagen peptide powder, 220 parts of sheep embryo extract, 30-70 parts of amino acid, 60-110 parts of sodium hyaluronate, 170 parts of corn extract, 120 parts of red ginseng extract, 170 parts of acerola cherry powder and 170 parts of green tea extract.
3. The preparation for promoting collagen regeneration according to claim 2, wherein the preparation is prepared from the following raw materials in parts by mass:
480 parts of glucan polypeptide, 150 parts of collagen peptide powder, 65 parts of sheep embryo extract, 50 parts of amino acid, 70 parts of sodium hyaluronate, 145 parts of corn extract, 135 parts of red ginseng extract, 120 parts of acerola powder and 145 parts of green tea extract.
4. The agent for promoting collagen regeneration according to any one of claims 1 to 3, wherein said agent is a liquid agent.
5. The method for preparing a collagen regeneration promoting agent according to any one of claims 1 to 3, wherein the preparation method comprises adding an emollient, a penetrant, and a solvent to the glucan polypeptide, the collagen peptide powder, the sheep placenta extract, the amino acid, the sodium hyaluronate, the corn extract, the red ginseng extract, the acerola cherry powder, and the green tea extract, mixing them uniformly, and filtering to obtain the final product.
6. The method for preparing a collagen regeneration promoting preparation according to claim 5, wherein the emollient comprises one or more of cumquat extract, blueberry extract and raspberry extract.
7. The method for preparing a collagen regeneration promoting agent according to claim 5, wherein said penetrating agent comprises an extract of Equisetum arvense.
8. The method for preparing an agent for promoting collagen regeneration according to claim 5, wherein the solvent comprises deionized water.
9. The method for preparing a collagen regeneration promoting preparation according to claim 5, wherein the ratio of the total amount of the glucan polypeptide, the collagen peptide powder, the sheep placenta extract, the amino acid, the sodium hyaluronate, the corn extract, the red ginseng extract, the acerola cherry powder and the green tea extract to the amount of the emollient, the amount of the penetrant and the solvent is 10-30:3-5:6-8: 30-70.
10. Use of a preparation for promoting collagen regeneration according to any one of claims 1 to 3 in a cosmetic product.
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