CN110314127A - One kind is dispelled striae of pregnancy essence cream and preparation method thereof - Google Patents

One kind is dispelled striae of pregnancy essence cream and preparation method thereof Download PDF

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CN110314127A
CN110314127A CN201910783722.1A CN201910783722A CN110314127A CN 110314127 A CN110314127 A CN 110314127A CN 201910783722 A CN201910783722 A CN 201910783722A CN 110314127 A CN110314127 A CN 110314127A
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peg
essence cream
pregnancy
striae
water
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CN110314127B (en
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庄培民
冯中军
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Hangzhou Qiandao Lake Blue Angel Industrial Co Ltd
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Hangzhou Qiandao Lake Blue Angel Industrial Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966Triazines or their condensed derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/004Aftersun preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

It dispels striae of pregnancy essence cream and preparation method thereof the present invention relates to one kind.The essence cream component includes: glycerol, carbomer, allantoin, Chlorphenesin, methyl hydroxybenzoate, isononyl isononanoate, caprylic/capric triglyceride, PEG-75 propylene glycol stearate, Butyrospermum parkii fruit fatty oil, PEG-10 phytosterol, butanediol, asiaticosid, Sodium Hyaluronate, Gotu Kola P.E, 1,2- hexylene glycol, Uvinul T 150, oat kernel extract, triethanolamine.The essence cream has removal striae of pregnancy effect well.

Description

One kind is dispelled striae of pregnancy essence cream and preparation method thereof
Technical field
The invention belongs to essence cream and preparation method thereof field, in particular to one kind is dispelled striae of pregnancy essence cream and its preparation side Method.
Background technique
Striae of pregnancy is that the significant physiology of skin appearance at the positions such as pregnancy period abdomen, buttocks, breast sexually revises, and is due to subcutaneous Elastic fibers elongates (based on transverse direction) or is broken, thinning of skin, and capillary exposure simultaneously portion fractures occurs, causes subcutaneously to go out Blood, forms the tortuous speckle of irregular aubergine, and every childbirth once can all leave one layer of corresponding striae of pregnancy (95.9%- 98.4%).It is fresh striped in the pregnancy period, and subcutaneous hemorrhage is gradually absorbed after childbirth, and color is become from aubergine or pale red Canescence or silvery white.With the extension of time, its length is basically unchanged, the fiber retraction of elongation makes width tend to constriction, breaks The fiber split cannot heal, and form scar, will leave throughout one's life, but width range is larger.It, may be first due to individual difference 3 years striae of pregnancy width and 1 year of same size after second people childbirth after people's childbirth, or 5 years after giving a birth with third individual Of same size, shade but has difference.
The control method of striae of pregnancy has prevention and has generated the reparation of striae of pregnancy.The such as pregnant preceding attention of prevention is taken exercises, It eats the food rich in protein more, enhances the elasticity of skin, after pregnancy, keep modest movement and balanced nutritious, avoid weight Increase excessive.The most of method reparations using operation removal and drug reparation of reparation of striae of pregnancy, removal of performing the operation are generated Method is although quick, but damages to the body of puerpera, and its price;And drug repairing effect is bad, slow effect.
In view of the above-mentioned problems, researcher obtains preferable effect by skin surface improvement.Such as Chinese patent CN108175740A discloses a kind of with effective prevention and the repair cream of pregrant abdominal stretch marks-removing effect and preparation method thereof, the reparation Frost includes following weight percent composition: 'Heijialun ' seed oil 3~6%;Butyrospermum parkii fruit rouge 2~4%;Olive oil 3~ 6%;Cocoa butter 2~4%;Methyl-monosilane alcohol hydroxyproline ester aspartate 5~10%;Pseudoalteromonas tunning mentions Take object 3~10%;Acetyl group tripeptides -1 3~6%;Collagen 2.5~5%;Gotu Kola P.E 2~4%;Oligopeptides -11~ 2%;Beta glucan 10~20%;The repair cream has a feather in one's cap in terms of striae of pregnancy size reduction and color aufhellung.But Be above-mentioned postpartum striae of pregnancy reparation need striae of pregnancy active material of dispelling it is more.
Summary of the invention
It dispels striae of pregnancy essence cream and preparation method thereof technical problem to be solved by the invention is to provide one kind, it is existing to overcome Have in technology striae of pregnancy reparation need it is more dispel striae of pregnancy active material the defects of.
Dispelling the present invention provides one kind, striae of pregnancy essence is newborn, and the essence cream component includes: glycerol 2 according to weight percent ~4%, carbomer 0.2~0.3%, allantoin 0.1~0.2%, Chlorphenesin 0.1~0.2%, methyl hydroxybenzoate 0.05~ 0.12%, isononyl isononanoate 2.5~4%, caprylic/capric triglyceride 1.6~3.3%, PEG-75 propylene glycol stearate 1 ~2.5%, Butyrospermum parkii fruit fatty oil 0.2~1.1%, PEG-10 phytosterol 0.4~0.8%, butanediol 5~8%, centella Glycosides 1.5~2.8%, Sodium Hyaluronate 0.05~0.12%, 2.5~4%, 1,2- hexylene glycol 1~2% of Gotu Kola P.E, second Base hexyl triazinone 1~2%, oat kernel extract 1~1.8%, triethanolamine 0.2~0.3%, the water of surplus.
The essence cream component includes: glycerol 2%, carbomer 0.2%, allantoin 0.1%, chlorobenzene according to weight percent Sweet ether 0.1%, methyl hydroxybenzoate 0.05%, isononyl isononanoate 2.5%, caprylic/capric triglyceride 1.6%, PEG-75 the third two Alcohol stearate 1%, Butyrospermum parkii fruit fatty oil 0.2%, PEG-10 phytosterol 0.4%, butanediol 5%, asiaticosid 1.5%, Sodium Hyaluronate 0.05%, Gotu Kola P.E 2.5%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat Benevolence extract 1%, triethanolamine 0.2%, the water of surplus.
The essence cream component includes: glycerol 3%, carbomer 0.25%, allantoin 0.15%, chlorine according to weight percent The sweet ether 0.15% of benzene, methyl hydroxybenzoate 0.1%, isononyl isononanoate 2.5%, caprylic/capric triglyceride 2%, PEG-75 the third two Alcohol stearate 1.8%, Butyrospermum parkii fruit fatty oil 0.5%, PEG-10 phytosterol 0.5%, butanediol 5%, asiaticosid 2%, Sodium Hyaluronate 0.07%, Gotu Kola P.E 3%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat kernel mentions Take object 1%, triethanolamine 0.25%, the water of surplus.
The essence cream component includes: glycerol 4%, carbomer 0.3%, allantoin 0.2%, chlorobenzene according to weight percent Sweet ether 0.2%, methyl hydroxybenzoate 0.12%, isononyl isononanoate 4%, caprylic/capric triglyceride 3.3%, PEG-75 propylene glycol Stearate 2.5%, Butyrospermum parkii fruit fatty oil 1.1%, PEG-10 phytosterol 0.8%, butanediol 8%, asiaticosid 2.8%, Sodium Hyaluronate 0.12%, Gotu Kola P.E 4%, 1,2- hexylene glycol 2%, Uvinul T 150 2%, oat kernel Extract 1.8%, triethanolamine 0.3%, the water of surplus.
The present invention also provides a kind of preparation methods of striae of pregnancy essence cream of dispelling, comprising:
(1) by glycerol 2~4%, carbomer 0.2~0.3%, allantoin 0.1~0.2%, Chlorphenesin 0.1~0.2%, The mixing of the water of methyl hydroxybenzoate 0.05~0.12% and 37.46~64.6%, is heated to 85 DEG C -90 DEG C;
(2) isononyl isononanoate 2.5~4%, caprylic/capric triglyceride 1.6~3.3%, PEG-75 propylene glycol is hard Resin acid ester 1~2.5%, Butyrospermum parkii fruit fatty oil 0.2~1.1% and PEG-10 phytosterol 0.4~0.8% mix, and are heated to 85℃-90℃;
(3) mixed solution after heating in step (1) and the solution after the middle heating of step (2) are pumped into emulsion pot respectively, Homogeneous 4~10min, 85 DEG C of -90 DEG C of 20~30min of heat preservation under vacuum and stirring, cooling;
(4) it disperses asiaticosid 1.5~2.8% and Sodium Hyaluronate 0.05~0.12% in butanediol 5~8%, 15%~25% water is added to stir to abundant dissolution;
(5) 42~45 DEG C are cooled in step (3), sequentially add dissolved solution, Gotu Kola P.E in step (4) 2.5~4%, 1,2- hexylene glycol 1~2%, Uvinul T 150 1~2%, oat kernel extract 1~1.8%, triethanolamine 0.2~0.3%, it discharges after stirring 20~30min;
The content of raw material is weight percentage in step (1)-(5).
The main triggering factors of Pathological Physiology of comprehensive striae of pregnancy first is that inflammation, therefore the gestational period can pass through destroy it is scorching Disease is reduced striae of pregnancy and is possibly realized.Asiaticosid and centella (CENTELLA ASIATICA) extract have pole in the present invention The function of good reparation skin inflammation.Oat alkaloid in the present invention in oat (AVENA SATIVA) benevolence extract is certain It can be able to suppress under concentration and directly related keratinocyte nuclear factor NF kappa B- α degradation occurs with inflammation, to prevent The phosphorylation of p65 protein protomer on nuclear factor NF kappa B, to block the generating process of cellular inflammation.In addition, swallow Wheat alkaloid is able to suppress the NF kappa B degrading enzymatic activity of tumor necrosis factor TNF-alpha induction, reduces inflammatory factor IL-8 Release.Asiaticosid, the Gotu Kola P.E of certain content are cooperateed with oat kernel extract repairs inflammation, bring reparation Inflammatory effects than individually the sum of anti-inflammatory effects brought by asiaticosid, Gotu Kola P.E or oat kernel extract also than It is good.
In addition, skin penetrant Uvinul T 150 of the invention can promote asiaticosid, snow grass (CENTELLA ASIATICA) extract and oat (AVENA SATIVA) benevolence extract through surface skin arrive at inflammatory cell, cicatricial tissue, Fibroblast etc., to make asiaticosid, avenge careless (CENTELLA ASIATICA) extract and oat (AVENA SATIVA) The repair of benevolence extract performance striae of pregnancy.
Butyrospermum parkii fruit rouge has effects that promote skin regeneration, prevents light aging in the present invention, to dermatitis, sunburn There is apparent promotion Healing with the skin of scar.
Beneficial effect
The present invention repairs inflammation using asiaticosid, Gotu Kola P.E and the collaboration of oat kernel extract, and collaboration plays pregnant It is pregnent the repair of line, while Uvinul T 150 and Butyrospermum parkii fruit rouge can increase the repair of striae of pregnancy.To Achieve the effect that striae of pregnancy of dispelling well.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited Range.
Embodiment 1
Dispelling the present embodiment provides one kind, striae of pregnancy essence is newborn, and the essence cream component is according to weight percent are as follows: glycerol 2%, Carbomer 0.2%, allantoin 0.1%, Chlorphenesin 0.1%, methyl hydroxybenzoate 0.05%, isononyl isononanoate 2.5%, octanoic acid/ Triglyceride DDD 1.6%, PEG-75 propylene glycol stearate 1%, Butyrospermum parkii fruit fatty oil 0.2%, PEG-10 phytosterol 0.4%, butanediol 5%, asiaticosid 1.5%, Sodium Hyaluronate 0.05%, Gotu Kola P.E 2.5%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.2%, the water of surplus.
The present embodiment also provides a kind of preparation method of striae of pregnancy essence cream of dispelling, specifically:
(1) by glycerol 2%, carbomer 0.2%, allantoin 0.1%, Chlorphenesin 0.1%, 0.05% and of methyl hydroxybenzoate 64.6% water puts into the mixing of water phase pot respectively, is heated to 85 DEG C;
(2) by isononyl isononanoate 2.5%, caprylic/capric triglyceride 1.6%, PEG-75 propylene glycol stearate 1%, Butyrospermum parkii fruit fatty oil 0.2% and PEG-10 phytosterol 0.4% put into the mixing of water phase pot respectively, are heated to 85 DEG C;
(3) mixed solution after heating in step (1) and the solution after the middle heating of step (2) are pumped into emulsion pot respectively, Open vacuum, stirring, homogeneous 4min, 85 DEG C of -90 DEG C of heat preservation 20min, cooling;
(4) it disperses asiaticosid 1.5% and Sodium Hyaluronate 0.05% in butanediol 5%, 15% water, stirring is added To abundant dissolution;
(5) 42 DEG C are cooled in step (3), sequentially add solution, Gotu Kola P.E after completely dissolution in step (4) 2.5%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.2% stir 20min After discharge;
The content of raw material is weight percentage in step (1)-(5).
Embodiment 2
Dispelling the present embodiment provides one kind, striae of pregnancy essence is newborn, and the essence cream component is according to weight percent are as follows: glycerol 3%, Carbomer 0.25%, allantoin 0.15%, Chlorphenesin 0.15%, methyl hydroxybenzoate 0.1%, isononyl isononanoate 2.5% are pungent Acid/Triglyceride DDD 2%, PEG-75 propylene glycol stearate 1.8%, Butyrospermum parkii fruit fatty oil 0.5%, PEG-10 plant steroid Alcohol 0.5%, butanediol 5%, asiaticosid 2%, Sodium Hyaluronate 0.07%, Gotu Kola P.E 3%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.25%, the water of surplus.
The present embodiment also provides a kind of preparation method of striae of pregnancy essence cream of dispelling, specifically:
(1) by glycerol 3%, carbomer 0.25%, allantoin 0.15%, Chlorphenesin 0.15%, 0.1% and of methyl hydroxybenzoate 50.73% water puts into water phase pot respectively and mixes, and is heated to 90 DEG C;
(2) by isononyl isononanoate 2.5%, caprylic/capric triglyceride 2%, PEG-75 propylene glycol stearate 1.8%, Butyrospermum parkii fruit fatty oil 0.5% and PEG-10 phytosterol 0.5% are put into water phase pot respectively mixes, and is heated to 90 ℃;
(3) mixed solution after heating in step (1) and the solution after the middle heating of step (2) are pumped into emulsion pot respectively, Open vacuum, stirring, homogeneous 8min, 85 DEG C of -90 DEG C of heat preservation 25min, cooling;
(4) it disperses asiaticosid 2% and Sodium Hyaluronate 0.07% in butanediol 5%, 25% water is added, stirring is extremely Sufficiently dissolution;
(5) 42~45 DEG C are cooled in step (3), sequentially add dissolved solution, Gotu Kola P.E in step (4) 3%, 1,2- hexylene glycol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.25% stir 30min After discharge;
The content of raw material is weight percentage in step (1)-(5).
Embodiment 3
Dispelling the present embodiment provides one kind, striae of pregnancy essence is newborn, and the essence cream component is according to weight percent are as follows: glycerol 4%, Carbomer 0.3%, allantoin 0.2%, Chlorphenesin 0.2%, methyl hydroxybenzoate 0.12%, isononyl isononanoate 4%, the octanoic acid/last of the ten Heavenly stems Acid glycerol three ester 3.3%, PEG-75 propylene glycol stearate 2.5%, Butyrospermum parkii fruit fatty oil 1.1%, PEG-10 phytosterol 0.8%, butanediol 8%, asiaticosid 2.8%, Sodium Hyaluronate 0.12%, Gotu Kola P.E 4%, 1,2- hexylene glycol 2%, Uvinul T 150 2%, oat kernel extract 1.8%, triethanolamine 0.3%, the water of surplus.
The present embodiment also provides a kind of preparation method of striae of pregnancy essence cream of dispelling, specifically:
(1) by glycerol 4%, carbomer 0.3%, allantoin 0.2%, Chlorphenesin 0.2%, 0.12% and of methyl hydroxybenzoate 47.46% water puts into water phase pot respectively and mixes, and is heated to 90 DEG C;
(2) by isononyl isononanoate 4%, caprylic/capric triglyceride 3.3%, PEG-75 propylene glycol stearate 2.5%, Butyrospermum parkii fruit fatty oil 1.1% and PEG-10 phytosterol 0.8% are put into water phase pot respectively mixes, and is heated to 85 ℃;
(3) mixed solution after heating in step (1) and the solution after the middle heating of step (2) are pumped into emulsion pot respectively, Open vacuum, stirring, homogeneous 10min, 85 DEG C of -90 DEG C of heat preservation 30min, cooling;
(4) it disperses asiaticosid 2.8% and Sodium Hyaluronate 0.12% in butanediol 8%, 15%% water is added and stirs It mixes to dissolution;
(5) 45 DEG C are cooled in step (3), sequentially add dissolved solution in step (4), Gotu Kola P.E 4%, 1,2- hexylene glycol 2%, Uvinul T 150 2%, oat kernel extract 1.8%, triethanolamine 0.3% go out after stirring 30min Material;
The content of raw material is weight percentage in step (1)-(5).
Comparative example 1
According to embodiment 1, essence cream component does not add asiaticosid, and the weight percent of water is changed to 81.1%, remaining is It is same as Example 1.
The preparation method of essence cream in addition to not adding asiaticosid, the weight percent of water is changed to 66.1% in step (1), Remaining is same as Example 1.
Comparative example 2
According to embodiment 1, essence cream component does not add Gotu Kola P.E, and the weight percent of water is changed to 82.1%, Yu Jun is same as Example 1.
The preparation method of essence cream, which is removed, does not add that Gotu Kola P.E, the weight percent of water is changed in step (1) Outside 67.1%, remaining is same as Example 1.
Comparative example 3
According to embodiment 1, essence cream component does not add Uvinul T 150, and the weight percent of water is changed to 80.6%, Remaining is same as Example 1.
The preparation method of essence cream, which is removed, does not add that Uvinul T 150, the weight percent of water is changed in step (1) Outside 65.6%, remaining is same as Example 1.
Comparative example 4
According to embodiment 1, essence cream component does not add oat kernel extract, and the weight percent of water is changed to 80.6%, Yu Jun is same as Example 1.
The preparation method of essence cream, which is removed, does not add that oat kernel extract, the weight percent of water is changed in step (1) Outside 65.6%, remaining is same as Example 1.
Comparative example 5
According to Chinese patent CN108175740A, this comparative example provides a kind of with effectively prevention and pregrant abdominal stretch marks-removing effect Repair cream, the component of the repair cream is according to weight percent are as follows: glycerol 5%, M68 3%, 'Heijialun ' seed oil 3%;Butter fruit Set fruit rouge 2%, olive oil 3%, cocoa butter 2%, vitamin E 2%, methyl-monosilane alcohol hydroxyproline ester aspartate 10%;Collagen 5%;Beta glucan 20%, Pseudoalteromonas tunning extract 10%;Acetyl group tripeptides -1 6%;Gotu Kola P.E 4%;Oligopeptides -1 2%, use up acyl ketone 0.5%, 1,2- hexylene glycol 0.5%, the water of surplus.
Striae of pregnancy removal test is as follows:
It selects the mother given birth to, have newborn striae of pregnancy, 22-35 years old age volunteer 160, be divided into 8 groups, respectively using real Apply striae of pregnancy product of dispelling in a 1-3 and comparative example 1-5, abdomen is divided into two regions using ventrimeson as boundary by volunteer, by with The principle of machine chooses wherein side and striae of pregnancy product of dispelling is used as to use position, and other side is as control position.It is each side-draw new Striae of pregnancy is marked at fresh and severity similar one, carries out the clinical evaluation of target skin lesion.By embodiment 1-3 and comparative example Dispel in 1-5 striae of pregnancy product respectively to volunteer in abdominal massaging using 3 months, 1 times/day of frequency of use, usage amount 5-10g/ It is secondary.Clinical judgment criteria: assessment striae of pregnancy integrally repairs, four items such as striae of pregnancy area, striae of pregnancy color, striae of pregnancy slackness Mesh, while being scored (0-5 points) using 6 point-scores, 5 points represent perfect state, and 0 point represents severe conditions, is averaged, and use The results are shown in Table 1.
Table 1
As shown in Table 1, product removal striae of pregnancy effect is relatively good in embodiment 1-3.It is not added when in essence cream of the present invention The effect of asiaticosid, Gotu Kola P.E, Uvinul T 150 or oat kernel extract, removal striae of pregnancy drops significantly It is low, it does not add asiaticosid, Gotu Kola P.E or oat kernel extract especially, illustrates asiaticosid, Gotu Kola P.E Collaboration, which is played, with oat kernel extract three increases removal striae of pregnancy effect, and the addition of Uvinul T 150 also directly affects Removal striae of pregnancy effect.Although product removal striae of pregnancy effect and the present invention are similar in comparative example 5, the two is dispelled gestation The composition of line is different, and comparative example 5 is methyl-monosilane alcohol hydroxyproline ester aspartate, collagen, beta glucan, false friendship For monad tunning extract, acetyl group tripeptides -1, Gotu Kola P.E and oligopeptides -1, and the embodiment of the present invention 3 is long-pending Asiaticoside, Gotu Kola P.E, Uvinul T 150 and oat kernel extract, it is exactly that centella is extracted that the two is uniquely identical Object, but the present invention utilizes asiaticosid, the synergistic effect of Gotu Kola P.E and oat kernel extract this three, that is to say, that The combination of this three is essential for removal striae of pregnancy effect, while Uvinul T 150 can increase removal gestation Line effect, this is entirely different with comparative example 5.

Claims (5)

1. one kind is dispelled striae of pregnancy essence cream, which is characterized in that the essence cream component according to weight percent include: glycerol 2~ 4%, carbomer 0.2~0.3%, allantoin 0.1~0.2%, Chlorphenesin 0.1~0.2%, methyl hydroxybenzoate 0.05~ 0.12%, isononyl isononanoate 2.5~4%, caprylic/capric triglyceride 1.6~3.3%, PEG-75 propylene glycol stearate 1 ~2.5%, Butyrospermum parkii fruit fatty oil 0.2~1.1%, PEG-10 phytosterol 0.4~0.8%, butanediol 5~8%, centella Glycosides 1.5~2.8%, Sodium Hyaluronate 0.05~0.12%, 2.5~4%, 1,2- hexylene glycol 1~2% of Gotu Kola P.E, second Base hexyl triazinone 1~2%, oat kernel extract 1~1.8%, triethanolamine 0.2~0.3%, the water of surplus.
2. essence cream according to claim 1, which is characterized in that the essence cream component includes: sweet according to weight percent Oil 2%, carbomer 0.2%, allantoin 0.1%, Chlorphenesin 0.1%, methyl hydroxybenzoate 0.05%, isononyl isononanoate 2.5%, Caprylic/capric triglyceride 1.6%, PEG-75 propylene glycol stearate 1%, Butyrospermum parkii fruit fatty oil 0.2%, PEG-10 plant Sterol 0.4%, butanediol 5%, asiaticosid 1.5%, Sodium Hyaluronate 0.05%, Gotu Kola P.E 2.5%, 1,2- oneself two Alcohol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.2%, the water of surplus.
3. essence cream according to claim 1, which is characterized in that the essence cream component includes: sweet according to weight percent Oil 3%, carbomer 0.25%, allantoin 0.15%, Chlorphenesin 0.15%, methyl hydroxybenzoate 0.1%, isononyl isononanoate 2.5%, caprylic/capric triglyceride 2%, PEG-75 propylene glycol stearate 1.8%, Butyrospermum parkii fruit fatty oil 0.5%, PEG- 10 phytosterols 0.5%, butanediol 5%, asiaticosid 2%, Sodium Hyaluronate 0.07%, Gotu Kola P.E 3%, 1,2- oneself Glycol 1%, Uvinul T 150 1%, oat kernel extract 1%, triethanolamine 0.25%, the water of surplus.
4. essence cream according to claim 1, which is characterized in that the essence cream component includes: sweet according to weight percent Oil 4%, carbomer 0.3%, allantoin 0.2%, Chlorphenesin 0.2%, methyl hydroxybenzoate 0.12%, isononyl isononanoate 4% are pungent Acid/Triglyceride DDD 3.3%, PEG-75 propylene glycol stearate 2.5%, Butyrospermum parkii fruit fatty oil 1.1%, PEG-10 plant Sterol 0.8%, butanediol 8%, asiaticosid 2.8%, Sodium Hyaluronate 0.12%, Gotu Kola P.E 4%, 1,2- hexylene glycol 2%, Uvinul T 150 2%, oat kernel extract 1.8%, triethanolamine 0.3%, the water of surplus.
5. a kind of preparation method for striae of pregnancy essence cream of dispelling, comprising:
(1) by glycerol 2~4%, carbomer 0.2~0.3%, allantoin 0.1~0.2%, Chlorphenesin 0.1~0.2%, oxybenzene The mixing of the water of methyl esters 0.05~0.12% and 37.46~64.6%, is heated to 85 DEG C -90 DEG C;
(2) by isononyl isononanoate 2.5~4%, caprylic/capric triglyceride 1.6~3.3%, PEG-75 propylene glycol stearic acid Ester 1~2.5%, Butyrospermum parkii fruit fatty oil 0.2~1.1% and PEG-10 phytosterol 0.4~0.8% mix, be heated to 85 DEG C- 90℃;
(3) mixed solution after heating in step (1) and the solution after the middle heating of step (2) are pumped into emulsion pot respectively, true Empty and stirring lower 4~10min of homogeneous, 85 DEG C of -90 DEG C of 20~30min of heat preservation, cooling;
(4) it disperses asiaticosid 1.5~2.8% and Sodium Hyaluronate 0.05~0.12% in butanediol 5~8%, is added 15%~25% water is stirred to dissolution;
(5) 42~45 DEG C are cooled in step (3), sequentially add dissolved solution, Gotu Kola P.E 2.5 in step (4) ~4%, 1,2- hexylene glycol 1~2%, Uvinul T 150 1~2%, oat kernel extract 1~1.8%, triethanolamine 0.2 ~0.3%, it discharges after stirring 20~30min;
The content of raw material is weight percentage in step (1)-(5).
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