CN109646319A - One kind is based on private gene customization ultra light sun block lotion and preparation method thereof - Google Patents
One kind is based on private gene customization ultra light sun block lotion and preparation method thereof Download PDFInfo
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- CN109646319A CN109646319A CN201811574893.5A CN201811574893A CN109646319A CN 109646319 A CN109646319 A CN 109646319A CN 201811574893 A CN201811574893 A CN 201811574893A CN 109646319 A CN109646319 A CN 109646319A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses one kind based on private gene customization ultra light sun block lotion and preparation method thereof, it is related to technical field of skin care, the technical issues of solution is how to improve skin-protection product in people by the repair function after ultraviolet injury, the lotion carries out raw material proportioning according to private genetic test, raw material components include: 1, 3- butanediol, fragrant fresh ketone, hexylene glycol, Sodium Hyaluronate, glycerol, polyacrylate cross-linked polymer -6, dipotassium glycyrrhizinate, sodium hydroxide, cera alba, Tween-80, citric acid, sodium citrate, Octocrilene, diisopropyl sebacate, disodium ethylene diamine tetraacetate, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside, tremella polysaccharides, isoamyl laurate, Phenylbenzimidazolesulfonic acid, Uvinul T 150, tocopherol, Uvinul A Plus, over it Apply M, fibronectin and Chiba Jasmine water.The present invention has good sun-proof reparation effect.
Description
Technical field
The present invention relates to technical field of skin care, more particularly to a kind of individual's gene that is based on to customize ultra light sun block lotion and its preparation
Method.
Background technique
Sun-proof is a wheezy topic, and ultraviolet (UV) A will lead to skin and photo-aging phenomena occurs, is held to cell generation
Long, cumulative photo oxidative damage causes reparation problem after damage to become particularly important.With the increasing of the sun-proof consciousness of people
By force, people start largely to use sunscreen product, however sunscreen product is single currently on the market and the object that is directed to all is most of
People can be used, bad for the using effect of a small number of specific crowds or individual, and the high skin care item of some SPFs are in people
It is poor by repairing performance after ultraviolet injury, it can also carry out immense pressure after use to this kind of specific crowd skin tape, or even occur
Allergic phenomena.
With the upgrading of people's level of consumption and demand, different consumer individuals for sunscreen product demand also at the moment
Variation, the even personal skin care that is intended to obtain a cutaneous gene for oneself and developed of some high-end consumer groups
Product customizes the accurate skin care concept of skin-protection product implementation according to private gene and gradually rises.
Fibronectin is the necessary highly active protein of human body cell Regeneration and Repair, and addition fibronectin can improve flesh comprehensively
Skin improves skin self-healing ability, plays the role of to reparation fabulous.
This invention uses with private gene the theory for customizing skin-protection product, according to different application on human skin genetic test reports
Situation, season, age, the dimension scientific design of region seven customize skin care instantly for announcement, skin physiology, dermatopathology, skin
Scheme, using Chiba Jasmine water as solvent, fibronectin is formulated as primary raw material, is designed a for ultraviolet damage
Hurt, to the salubrious ultra light sun block lotion of anti-light aging.It is added fibronectin in lotion, the special RGD sequence of fibronectin can allow battalion
Feeding substance is continually supplied to everywhere, is provided logistic material guarantee to repair, is stimulated cell division, increases cuticle thickness, be
Exposed capillary is put on thick coat again, effectively solves the problems, such as reparation.
Summary of the invention
In view of the deficiencies of the prior art, technical problem solved by the invention be how to improve skin-protection product people by
Repair function after ultraviolet injury.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of customize sunscreen based on private gene
Liquid carries out raw material proportioning according to private genetic test, is made of following hundred score of raw material components quality: 1,3-BDO 1%~
16%, fragrant fresh ketone 0.01%~3%, hexylene glycol 0.1%~8%, Sodium Hyaluronate 0.0001%~3%, glycerol 1%~
20%, polyacrylate cross-linked polymer -6 0.02%~5%, dipotassium glycyrrhizinate 0.05%~10%, sodium hydroxide 0.05%
~2%, cera alba 0.5%~18%, Tween-80 0.08%~4%, citric acid 0.0001%~1%, sodium citrate
0.0001%~1%, Octocrilene 0.005%~8%, diisopropyl sebacate 0.04%~8%, disodium ethylene diamine tetraacetate
0.02%~5%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 0.5%~15%, tremella polysaccharides 0.05%~5%,
Isoamyl laurate 0.05%~10%, Phenylbenzimidazolesulfonic acid 0.1%~8%, Uvinul T 150 0.05%~
6%, applied over tocopherol 0.05%~5%, Uvinul A Plus 0.01%~8%, day M 1%~
10%, fibronectin 2%~20%, surplus are Chiba Jasmine water.
Another technical problem that the present invention solves is to provide one kind after people are by ultraviolet injury, and repairing performance is good
Skin-protection product preparation method.
In order to solve the above technical problems, the technical solution adopted by the present invention is that a kind of customize ultra light sun block lotion based on private gene
Preparation method carries out raw material proportioning according to private genetic test, raw material components is made by formula, comprising the following steps:
(1) Sodium Hyaluronate, polyacrylate cross-linked polymer -6 are dissolved in 1,3-BDO, are uniformly dispersed to obtain
One mixture；
(2) 1,3-BDO and glycerol are taken, hexylene glycol, fragrant fresh ketone are sequentially added, 40 DEG C to 60 DEG C heating stirrings to powder
Last particle is completely dissolved, and is uniformly dispersed, and the second mixture is obtained；
(3) sodium hydroxide is added in Chiba Jasmine water, stirs to being completely dissolved, obtains third mixture；
(4) M will be applied over day to be added in Chiba Jasmine water, is dispersed with stirring completely, is obtained the 4th mixture；
(5) by glycerol, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, citric acid, sodium citrate, tremella polysaccharides, phenyl
Benzimidazole sulfonic acid, Chiba Jasmine water, the first mixture are added sequentially to kettle, stir and are heated to 70 DEG C~80 DEG C, to
Dissolution completely, opens homogeneous insulated and stirred 20 minutes after five minutes, obtains water phase；
(6) by cera alba, Tween-80, Octocrilene, diisopropyl sebacate, arachidic alcohol (and) docosyl alcohol (and)
Arachidic alcohol glucoside, isoamyl laurate, Uvinul T 150, Uvinul A Plus, tocopherol
Be added sequentially to oil cauldron, stir and be heated to 70 DEG C~80 DEG C, it is to be dissolved completely, obtain oily phase；
(7) after adjusting water phase pH using third mixture, the oil phase is added to the aqueous phase, opens homogeneous 10 minutes, keeps the temperature later
Stirring 20 minutes；
(8) 45 DEG C are cooled to, the second mixture, the 4th mixture, fibronectin is sequentially added, obtains finished product.
Preferably, the step (5), in (six), temperature when stirring is 80 DEG C, the speed of stirring be 40rpm~
600rpm。
Compared with prior art products, the invention has the following beneficial effects:
Product of the present invention does not use titanium dioxide as sun-screening agent, avoids phenomenon not easy to apply and titanium dioxide
The risk of grain blocking pore；Fibronectin has the function of repair cell, not only can be with after tanning severely in sun-proof insufficient situation
Shallow cell is repaired, corium deep layer cells below can also be repaired, plays the role of repairing skin, is had sun-proof well
Repair effect.
Specific embodiment
A specific embodiment of the invention is further described below with reference to embodiment, but is not to limit of the invention
It is fixed.
Embodiment one:
One kind customizing ultra light sun block lotion based on private gene, raw material proportioning is carried out according to private genetic test, by following raw material
Hundred score of constituent mass is made: 1,3-BDO 10%, fragrant fresh ketone 0.2%, hexylene glycol 0.5%, Sodium Hyaluronate 0.2%, sweet
Oil 4%, polyacrylate cross-linked polymer -60.05%, dipotassium glycyrrhizinate 0.4%, sodium hydroxide 0.6%, cera alba 1.5%,
Tween-80 3%, citric acid 0.0005%, sodium citrate 0.51%, Octocrilene 5%, diisopropyl sebacate 6%,
Disodium ethylene diamine tetraacetate 0.2%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 3%, tremella polysaccharides 2%, lauric acid
Isopentyl ester 6%, Phenylbenzimidazolesulfonic acid 5%, Uvinul T 150 0.5%, tocopherol 0.1%, lignocaine oxybenzene first
It is Chiba Jasmine water that M 2%, fibronectin 8%, surplus are applied over acyl group hexyl-benzoate 2%, day.
Embodiment two:
One kind customizing ultra light sun block lotion based on private gene, raw material proportioning is carried out according to private genetic test, by following raw material
Hundred score of constituent mass is made: 1,3-BDO 8%, fragrant fresh ketone 0.3%, hexylene glycol 0.6%, Sodium Hyaluronate 0.5%, glycerol
5%, polyacrylate cross-linked polymer -60.03%, dipotassium glycyrrhizinate 0.4%, sodium hydroxide 0.4%, cera alba 3%, poly- mountain
Pear ester -802%, citric acid 0.0002%, sodium citrate 0.2%, Octocrilene 5%, diisopropyl sebacate 6%, ethylenediamine
Tetraacethyl disodium 0.1%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 2%, tremella polysaccharides 3%, isoamyl laurate
6%, Phenylbenzimidazolesulfonic acid 5%, Uvinul T 150 0.5%, tocopherol 0.05%, lignocaine hydroxyl Benzoylbenzene
It is Chiba Jasmine water that M 2%, fibronectin 18%, surplus are applied over hexyl formate 4%, day.
Embodiment three:
One kind customizing ultra light sun block lotion based on private gene, raw material proportioning is carried out according to private genetic test, by following raw material
Hundred score of constituent mass is made: 1,3-BDO 4%, fragrant fresh ketone 0.3%, hexylene glycol 0.6%, Sodium Hyaluronate 0.3%, glycerol
8%, polyacrylate cross-linked polymer -60.02%, dipotassium glycyrrhizinate 0.3%, sodium hydroxide 0.4%, cera alba 1.5%, poly-
Sorb ester -80 2%, citric acid 0.0004%, sodium citrate 0.4%, Octocrilene 5%, diisopropyl sebacate 5%, second two
Amine tetraacethyl disodium 0.1%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 5%, tremella polysaccharides 1%, lauric acid isoamyl
Ester 6%, Phenylbenzimidazolesulfonic acid 5%, Uvinul T 150 0.6%, tocopherol 0.06%, lignocaine oxybenzene formoxyl
It is Chiba Jasmine water that M 3%, fibronectin 12%, surplus are applied over hexyl-benzoate 1%, day.
One kind customizing ultra light sun block lotion preparation method based on private gene, carries out raw material proportioning according to private genetic test, will
Raw material components are made by formula, comprising the following steps:
(1) Sodium Hyaluronate, polyacrylate cross-linked polymer -6 are dissolved in 1,3-BDO, are uniformly dispersed to obtain
One mixture；
(2) 1,3-BDO and glycerol are taken, hexylene glycol, fragrant fresh ketone are sequentially added, 40 DEG C to 60 DEG C heating stirrings to powder
Last particle is completely dissolved, and is uniformly dispersed, and the second mixture is obtained；
(3) sodium hydroxide is added in Chiba Jasmine water, stirs to being completely dissolved, obtains third mixture；
(4) M will be applied over day to be added in Chiba Jasmine water, is dispersed with stirring completely, is obtained the 4th mixture；
(5) by glycerol, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, citric acid, sodium citrate, tremella polysaccharides, phenyl
Benzimidazole sulfonic acid, Chiba Jasmine water, the first mixture are added sequentially to kettle, stir and are heated to 70 DEG C~80 DEG C, to
Dissolution completely, opens homogeneous insulated and stirred 20 minutes after five minutes, obtains water phase；
(6) by cera alba, Tween-80, Octocrilene, diisopropyl sebacate, arachidic alcohol (and) docosyl alcohol (and)
Arachidic alcohol glucoside, isoamyl laurate, Uvinul T 150, Uvinul A Plus, tocopherol
Be added sequentially to oil cauldron, stir and be heated to 70 DEG C~80 DEG C, it is to be dissolved completely, obtain oily phase；
(7) after adjusting water phase pH using third mixture, the oil phase is added to the aqueous phase, opens homogeneous 10 minutes, keeps the temperature later
Stirring 20 minutes.
(8) 45 DEG C are cooled to, the second mixture, the 4th mixture, fibronectin is sequentially added, obtains invention finished product.
Preferably, the step (5), in (six), temperature when stirring is 80 DEG C, the speed of stirring be 40rpm~
600rpm。
To embody the product of the present invention after-sun recovery impact of performance, it is provided with control experiment, control group 1,2 is respectively on the market
The common sunscreen product of fibronectin is not added, control group 3 is to be added to its ingredient of the product of the present invention of fibronectin and reality
It is identical to apply example one, three set products are distributed to 60 volunteers and use, obtain effect comparation and assessment tables of data used below:
From in upper table as it can be seen that the product of the present invention for being added to fibronectin have in 60 20% volunteer think repair function
It can be particularly useful, hence it is evident that the 7% and 5% of the existing product of fibronectin is not added with higher than other two groups, it can be seen that, it is added to
The product of the present invention of fibronectin has good sun-proof reparation effect.
Detailed description is made that embodiments of the present invention in conjunction with the embodiments above, but the present invention be not limited to it is described
Embodiment.To those skilled in the art, without departing from the principles and spirit of the present invention, to these realities
The mode of applying carries out various change, modification, replacement and variant are still fallen in protection scope of the present invention.
Claims (6)
1. one kind customizes ultra light sun block lotion based on private gene, which is characterized in that raw material proportioning is carried out according to private genetic test, by
Following hundred score of raw material components quality is made: 1,3-BDO 1%~16%, fragrant fresh ketone 0.01%~3%, hexylene glycol 0.1%
~8%, Sodium Hyaluronate 0.0001%~3%, glycerol 1%~20%, polyacrylate cross-linked polymer -6 0.02%~
5%, dipotassium glycyrrhizinate 0.05%~10%, sodium hydroxide 0.05%~2%, cera alba 0.5%~18%, Tween-80
0.08%~4%, citric acid 0.0001%~1%, sodium citrate 0.0001%~1%, Octocrilene 0.005%~8%, the last of the ten Heavenly stems
Diisopropyl adipate 0.04%~8%, disodium ethylene diamine tetraacetate 0.02%~5%, arachidic alcohol (and) docosyl alcohol (and) peanut
Alcohol glucoside 0.5%~15%, tremella polysaccharides 0.05%~5%, isoamyl laurate 0.05%~10%, phenylbenzimidazol
Sulfonic acid 0.1%~8%, Uvinul T 150 0.05%~6%, tocopherol 0.05%~5%, lignocaine oxybenzene formoxyl
It is Chiba Jasmine water that M 1%~10%, fibronectin 2%~20%, surplus are applied over hexyl-benzoate 0.01%~8%, day.
2. as described in claim 1 customize ultra light sun block lotion based on private gene, which is characterized in that by following raw material components quality
Hundred scores are made: 1,3-BDO 10%, hexylene glycol 0.5%, Sodium Hyaluronate 0.2%, glycerol 4%, gathers fragrant fresh ketone 0.2%
Acrylate crosspolymers -6 0.05%, dipotassium glycyrrhizinate 0.4%, sodium hydroxide 0.6%, cera alba 1.5%, poly- sorb
Ester -80 3%, citric acid 0.0005%, sodium citrate 0.51%, Octocrilene 5%, diisopropyl sebacate 6%, ethylenediamine
Tetraacethyl disodium 0.2%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 3%, tremella polysaccharides 2%, isoamyl laurate
6%, Phenylbenzimidazolesulfonic acid 5%, Uvinul T 150 0.5%, tocopherol 0.1%, lignocaine hydroxyl Benzoylbenzene
It is Chiba Jasmine water that M 2%, fibronectin 8%, surplus are applied over hexyl formate 2%, day.
3. as described in claim 1 customize ultra light sun block lotion based on private gene, which is characterized in that by following raw material components quality
Hundred scores are made: 1,3-BDO 8%, fragrant fresh ketone 0.3%, hexylene glycol 0.6%, Sodium Hyaluronate 0.5%, glycerol 5%, poly- third
Olefin(e) acid ester cross-linked polymer -6 0.03%, dipotassium glycyrrhizinate 0.4%, sodium hydroxide 0.4%, cera alba 3%, Tween-80
2%, citric acid 0.0002%, sodium citrate 0.2%, Octocrilene 5%, diisopropyl sebacate 6%, ethylenediamine tetra-acetic acid two
Sodium 0.1%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 2%, tremella polysaccharides 3%, isoamyl laurate 6%, phenyl
Benzimidazole sulfonic acid 5%, Uvinul T 150 0.5%, tocopherol 0.05%, Uvinul A Plus
4%, it is Chiba Jasmine water that M 2%, fibronectin 18%, surplus are applied over day.
4. as described in claim 1 customize ultra light sun block lotion based on private gene, which is characterized in that by following raw material components quality
Hundred scores are made: 1,3-BDO 4%, fragrant fresh ketone 0.3%, hexylene glycol 0.6%, Sodium Hyaluronate 0.3%, glycerol 8%, poly- third
Olefin(e) acid ester cross-linked polymer -6 0.02%, dipotassium glycyrrhizinate 0.3%, sodium hydroxide 0.4%, cera alba 1.5%, polysorbate -
80 2%, citric acid 0.0004%, sodium citrate 0.4%, Octocrilene 5%, diisopropyl sebacate 5%, ethylenediamine tetrem
Acid disodium 0.1%, arachidic alcohol (and) docosyl alcohol (and) arachidic alcohol glucoside 5%, tremella polysaccharides 1%, isoamyl laurate 6%,
Phenylbenzimidazolesulfonic acid 5%, Uvinul T 150 0.6%, tocopherol 0.06%, lignocaine oxybenzene formylbenzoate
It is Chiba Jasmine water that M 3%, fibronectin 12%, surplus are applied over own ester 1%, day.
5. a kind of customize ultra light sun block lotion preparation method based on private gene as Claims 1-4 is described in any item, feature exists
In, according to private genetic test carry out raw material proportioning, raw material components are made by formula, comprising the following steps:
(1) Sodium Hyaluronate, polyacrylate cross-linked polymer -6 are dissolved in 1,3-BDO, it is mixed is uniformly dispersed to obtain first
Close object；
(2) 1,3-BDO and glycerol are taken, hexylene glycol, fragrant fresh ketone are sequentially added, 40 DEG C to 60 DEG C heating stirrings to powder
Grain is completely dissolved, and is uniformly dispersed, is obtained the second mixture；
(3) sodium hydroxide is added in Chiba Jasmine water, stirs to being completely dissolved, obtains third mixture；
(4) M will be applied over day to be added in Chiba Jasmine water, is dispersed with stirring completely, is obtained the 4th mixture；
(5) by glycerol, disodium ethylene diamine tetraacetate, dipotassium glycyrrhizinate, citric acid, sodium citrate, tremella polysaccharides, phenyl benzo
Imidazole sulfonic acid, Chiba Jasmine water, the first mixture are added sequentially to kettle, stir and are heated to 70 DEG C~80 DEG C, to be dissolved
Completely, homogeneous insulated and stirred 20 minutes after five minutes are opened, water phase is obtained；
(6) by cera alba, Tween-80, Octocrilene, diisopropyl sebacate, arachidic alcohol (and) docosyl alcohol (and) peanut
Alcohol glucoside, isoamyl laurate, Uvinul T 150, Uvinul A Plus, tocopherol are successively
Be added to oil cauldron, stir and be heated to 70 DEG C~80 DEG C, it is to be dissolved completely, obtain oily phase；
(7) after adjusting water phase pH using third mixture, the oil phase is added to the aqueous phase, unlatching homogeneous 10 minutes, later insulated and stirred
20 minutes；
(8) 45 DEG C are cooled to, the second mixture, the 4th mixture, fibronectin is sequentially added, obtains finished product.
6. as claimed in claim 5 customize ultra light sun block lotion preparation method based on private gene, which is characterized in that the step
(5), in (six), temperature when stirring is 80 DEG C, and the speed of stirring is 40rpm~600rpm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314127A (en) * | 2019-08-23 | 2019-10-11 | 杭州千岛湖蓝色天使实业有限公司 | One kind is dispelled striae of pregnancy essence cream and preparation method thereof |
| WO2021102873A1 (en) * | 2019-11-29 | 2021-06-03 | Beiersdorf Daily Chemical (Wuhan) Co., Ltd. | An oil-in-water sunscreen composition |
-
2018
- 2018-12-21 CN CN201811574893.5A patent/CN109646319A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314127A (en) * | 2019-08-23 | 2019-10-11 | 杭州千岛湖蓝色天使实业有限公司 | One kind is dispelled striae of pregnancy essence cream and preparation method thereof |
| WO2021102873A1 (en) * | 2019-11-29 | 2021-06-03 | Beiersdorf Daily Chemical (Wuhan) Co., Ltd. | An oil-in-water sunscreen composition |
| CN114144161A (en) * | 2019-11-29 | 2022-03-04 | 拜尔斯道夫股份有限公司 | Oil-in-water sunscreen compositions |
| CN114144161B (en) * | 2019-11-29 | 2023-11-24 | 拜尔斯道夫股份有限公司 | Oil-in-water sunscreen composition |
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Application publication date: 20190419 |