CN106491439A - A kind of anti-acne essence compositionss, anti-acne essence and preparation technology - Google Patents
A kind of anti-acne essence compositionss, anti-acne essence and preparation technology Download PDFInfo
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Abstract
The present invention relates to a kind of anti-acne essence compositionss, anti-acne essence and preparation technology.The invention that purpose is to provide can with active balance fat secretion the effects such as.Technical scheme is：A kind of anti-acne essence compositionss, including raw material as follows：Composition in compositionss one is：Lecithin etc.；Composition in compositionss two is ethanol etc.；Composition in compositionss three is：Asiaticoside etc..A kind of anti-acne essence, including raw material as follows：A groups：Plant sterol etc.；B groups：Tremella polysaccharide etc.；C groups：Butanediol etc..The preparation method of above-mentioned anti-acne essence compositionss, comprises the steps successively：1) dissolve stock dispersion after C groups raw material being mixed heating, persistently stirring cooling；2) by B groups raw material sequentially add and homogenizing, stirring, disperse, after the completion of persistently stir；3) A group raw materials heated and stirred is dissolved；4) treat that step 2 completes to lower the temperature, A groups raw material is added, persistently stirring cooling, filtering and discharging.
Description
Technical field
The present invention relates to small pox repairs field, specifically a kind of anti-acne essence compositionss, anti-acne essence and system
Standby technique.
Background technology
In general, either teenager or adult, the people of oily skin compares and can cause skin oil and fat excessive secretion
Situation produce, however, skin oil and fat is the balance for adjusting hair and skin and hair in itself, ensure pliability and the hair of skin
The brightness that sends out, while the invasion and attack of external environment condition are also resisted, but, excessive fat secretion can be such that microorganism quickly increases in hair follicle
Raw, clogging of pores is easily caused, the generation of acne and the generation of inflammation is caused, another easily causes skin oil and fat excessive secretion
Reason, is exactly that skin oil and fat secretion is mainly androgen and adjusts produced by hormonal imbalance, mainly by male mainly by
Testosterone is controlled, and each sebaceous cell makes testosterone be converted into dihydrotestosterone (DHT) containing 5a- reductases, and DHT turns
To promotion sebaceous gland, to produced sebum.Therefore, hormonal imbalance, such as testosterone content are excessive, result in excessive
5a- reductases and DHT, as a result cause the increase of epidermis and deep skin sebum quantity, and other non-hormonal factors are same
Smegma (such as ambient temperature, age, ultraviolet etc.) can also be promoted, therefore, consumer has small pox reparation to these
The requirement product of effect is more and more urgent.
Content of the invention
The technical problem to be solved in the present invention is to provide a kind of effectively prevention small pox and produces and repair anti-acne essence after pox
Compositionss, anti-acne essence and preparation technology, with active balance fat secretion, suppress increasing, contracting for small pox propionibacterium acness
The time of short pox scar healing, and the small pox skin to inflammation, play the effect for reparation of releiving in time.
For solving above-mentioned technical problem, the technical scheme that the present invention is provided is：
A kind of anti-acne essence compositionss, including raw material and weight portion as follows：
One 3.0-5.0 of compositionss, two 5.0-8.0 of compositionss；Three 0.1-1.0 of compositionss；
Composition and percentage by weight in compositionss one be：Lecithin 9-11, butanediol 23-27, Salix alba (SALIX
ALBA) bark extract 9-11, bone fat phenol 0.9-1.1, evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract
0.9-1.1, remaining are water；
Composition and percentage by weight in compositionss two be：Ethanol 18-22, Propylene Glycol 28-32, pale flag (IRIS
FLORENTINA) root extract 4.4-4.6, zinc sulfate 0.4-0.6, retinyl palmitate 0.4-0.6, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 36-44, Madecassic acid 36-44, Herba Centellae
Sour 18-22.
Composition and percentage by weight in compositionss one be：Lecithin 10, butanediol 25, Salix alba bark extract 10,
Bone fat phenol 1.0, evergreen magnolia leaf extract 1.0, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 20, Propylene Glycol 30, pale flag root extract 4.5, sulfur
Sour zinc 0.5, retinyl palmitate 0.5, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 40, Madecassic acid 40, asiatic acid 20.
A kind of anti-acne essence, including raw material and percentage by weight as follows：
A groups：Plant sterol 1.4-1.6, octyl dodecanol lauroyl glutamate ester 1.4-1.6, three 0.1-1.0 of compositionss；
B groups：Tremella (TREMELLA FUCIFORMIS) polysaccharide 4.9-5.1, -1 9-11 of biological carbohydrate gum；One 3.0- of compositionss
5.0th, two 5.0-8.0 of compositionss；
C groups：Butanediol 5.9 6.1, glycerol 2.9 3.1,1,2 pentanediols 2.9 3.1, glycyrrhizic acid 2 0.09 0.11, essence
Propylhomoserin 0.11 0.13, carbomer 0.19 0.21, hyaluronate sodium 0.04-0.06, -73 0.009-0.011 of quaternary ammonium salt, remaining
For deionized water.
The preparation method of above-mentioned anti-acne essence compositionss, comprises the steps successively：
1), when the mixing of C groups raw material being heated to 85 DEG C, homogenizing, stirring dissolve stock dispersion, then persistently stir
It is cooled to 45 DEG C；
2) after C groups raw material reach 45 DEG C after, by B groups raw material sequentially add and homogenizing, stirring, disperse, after the completion of persistently stir
Mix and be cooled to 35 DEG C；
3) A group raw materials are heated to 45 DEG C, standby after stirring and dissolving；
4) after step 2 completes to be cooled to 35 DEG C, A groups raw material is added, after persistently stirring is cooled to 30 DEG C, filtering and discharging
?.
Described homogenizing adopts high speed dispersor.
Step 1) in homogenizing time be preferably 5Mins, mixing speed is preferably 600rpm.
Step 2) in homogenizing time be preferably 1Mins, mixing speed is preferably 600rpm.
The invention has the beneficial effects as follows：Lecithin/butanediol/Salix alba (SALIX ALBA) bark in compositionss one is extracted
Thing/bone fat phenol/evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract), can be to small pox inflammatory factor prostate
Plain (PEG2) produces good inhibition with interleukin (IL-8)；
Water in compositionss two/ethanol/Propylene Glycol/pale flag (IRIS FLORENTINA) root extract/zinc sulfate/
Retinyl palmitate)：Face's fat secretion can be balanced, it is ensured that hair follicle will not produce cutin and pile up situation, it is to avoid antibacterial grows
The raw situation with inflammation is produced；
Asiaticoside/Madecassic acid/asiatic acid in compositionss three) the pox scar for having produced can be removed, plus
Fast cicatrix healing rate, replys skin normal condition.And asiaticoside/Madecassic acid/the product that is extracted using titrimetry
Snow oxalic acid), it is a kind of pharmaceutical grade Herba Centellae extract of standard, separates from pure fractionating section, wherein containing super
Cross 95% active factorses, respectively 60% asiatic acid and Madecassic acid/40% asiaticoside；And utilize conventional solvent
The Herba Centellae extract of extraction, only about 80% active factorses.
Using combination of the above thing configure essence, can active balance fat secretion, suppress small pox acne propanoic acid
The growth of bacillus, shortens the time of pox scar healing, and the small pox skin to inflammation, plays the effect for reparation of releiving in time.
Description of the drawings
Fig. 1 is to reduce the propionibacterium acness contrast effect figure on skin.
Specific embodiment
Further illustrate below in conjunction with specific embodiment.
Embodiment one：
Anti-acne essence compositionss, the composition and weight portion for containing be：Compositionss 1, compositionss 2 5.0, compositionss
3 0.1.
Composition and percentage by weight in compositionss one be：Lecithin 9, butanediol 27, Salix alba (SALIX ALBA) bark
Extract 9, bone fat phenol 1.1, evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract 0.9, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 22, Propylene Glycol 28, pale flag (IRIS
FLORENTINA) root extract 4.6, zinc sulfate 0.4, retinyl palmitate 0.6, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 36, Madecassic acid 44, asiatic acid 20.
Anti-acne essence
Anti-acne elite liquid and preparation method thereof comprises the steps：
1., when the mixing of C groups raw material being heated to 85 DEG C, using Ultra Turrax homogenizing head homogenizing 5Mins, stir
Speed 600rpm, after whole stock dispersion dissolvings, persistently stirring is cooled to 45 DEG C；
2. after C groups raw material reaches 45 DEG C, B group raw materials are sequentially added, using high speed dispersor homogenizing 1Mins, stirred
Speed 600rpm, after the completion of dispersion, persistently stirring is cooled to 35 DEG C；
3. A group raw materials are heated to 45 DEG C, standby after stirring and dissolving；
4. after step 2 is cooled to 35 DEG C, A groups raw material is added, after persistently stirring is cooled to 30 DEG C, filtering and discharging is
Into.
Embodiment two：Anti-acne essence compositionss, the composition and weight portion for containing be：Compositionss 1, compositionss two
6.0th, compositionss 3 0.5.
Composition and percentage by weight in compositionss one be：Lecithin 10, butanediol 25, Salix alba (SALIX ALBA) bark
Extract 10, bone fat phenol 1.0, evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract 1.0, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 20, Propylene Glycol 30, pale flag (IRIS
FLORENTINA) root extract 4.5, zinc sulfate 0.5, retinyl palmitate 0.5, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 40, Madecassic acid 40, asiatic acid 20.
Anti-acne essence
Anti-acne elite liquid and preparation method thereof comprises the steps：
1. when the mixing of C groups raw material being heated to 85 DEG C, homogenizing 5Mins, mixing speed
600rpm, after whole stock dispersion dissolvings, persistently stirring is cooled to 45 DEG C；
2., after C groups raw material reaches 45 DEG C, B group raw materials are sequentially added, using Ultra Turrax homogenizing head homogenizing
1Mins,
Mixing speed 600rpm, after the completion of dispersion, persistently stirring is cooled to 35 DEG C；
3. A group raw materials are heated to 45 DEG C, standby after stirring and dissolving；
4., after step 2 is cooled to 35 DEG C, A groups raw material is added, after persistently stirring is cooled to 30 DEG C, filtering and discharging, i.e.,
Into.
Embodiment three：Anti-acne essence compositionss, the composition and weight portion for containing be：Compositionss 1, compositionss two
6.0th, compositionss 3 1.0.
Composition and percentage by weight in compositionss one be：Lecithin 11, butanediol 23, Salix alba (SALIX ALBA) bark
Extract 11, bone fat phenol 0.9, evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract 1.1, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 18, Propylene Glycol 32, pale flag (IRIS
FLORENTINA) root extract 4.4, zinc sulfate 0.6, retinyl palmitate 0.4, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 44, Madecassic acid 35, asiatic acid 21.
Anti-acne essence
Anti-acne elite liquid and preparation method thereof comprises the steps：
1) when the mixing of C groups raw material being heated to 85 DEG C, using Ultra Turrax homogenizing head homogenizing 5Mins, stir
Speed 600rpm, after whole stock dispersion dissolvings, persistently stirring is cooled to 45 DEG C；
2) after C groups raw material reaches 45 DEG C, B group raw materials are sequentially added, using Ultra Turrax homogenizing head homogenizing
1Mins, mixing speed 600rpm, after the completion of dispersion, persistently stirring is cooled to 35 DEG C；
3) A group raw materials are heated to 45 DEG C, standby after stirring and dissolving；
4) after step 2 is cooled to 35 DEG C, A groups raw material is added, after persistently stirring is cooled to 30 DEG C, filtering and discharging is
Into.
Efficacy test：
1st, testing in vitro suppresses propionibacterium acness to increase
Testing program
Method：By concentration for per milliliter of 10^8 colony forming units propionibacterium acness suspension be seeded to respectively containing
In the agar plate of variable concentrations quaternary amine -73, culture plate is cultivated 2 days in 37 DEG C of oxygen-free environments, culture is measured after terminating
Growth of microorganism in agar, -73 concentration of minimum quaternary amine that can be suppressed growth of microorganism is considered as minimum inhibitory concentration
(MIC).
Testing time：48 hours
Test temperature：37℃
Tested product：Anti-acne essence
Tested result：See the table below
| Bacterial strain | MIC (%)) |
| 30 plants of propionibacterium acness being clinically separated | 0.00003‐0.00005 |
| Propionibacterium acness ATCC6919 | 0.00003 |
| Propionibacterium acness ATCC11827 | 0.00003 |
| Propionibacterium acness ATCC11828 | 0.00003 |
Summarize：The quaternary amine -73 of low consumption can also suppress the growth of propionibacterium acness.
2nd, internal test reduces the propionibacterium acness on skin
Testing program
Method：By the anti-acne essence of the quaternary amine -73 containing 0.004%, it is put in facial film bag and uses as base material, in
Using respectively containing the facial film (standard specimen) for adding quaternary amine -73 before sleeping daily, with the facial film (blank sample) without quaternary amine -73
Test, is wiped over the skin surface at the wing of nose with aseptic cotton carrier, is then incubated in PUK-MEDIUM under anaerobic, so
Clump count agar on is calculated afterwards and the quantity of the antibacterial that lives.
Testing time：8 days
Tested product：Anti-acne essence
Tested result：See Fig. 1
Summarize：The number that skin acne propionibacterium can soon be reduced using the elite facial mask liquid containing quaternary amine -73
Mesh.
3rd, internal test ----reduce skin epidermis fat secretory volume
Testing program
Method：By the ((water/ethanol/Propylene Glycol/pale flag (IRIS FLORENTINA) root extract/sulfur containing 6%
Sour zinc/retinyl palmitate (compositionss two)) the essence oily skin testees test that has acne symptom at 12 respectively,
Use 2 times daily, tested position is respectively in face's forehead, nose, lip, buccal both sides；Using German CK companies skin test
The oils and fatss test probe of 580 models of instrument MPA records above face position sebum level ratio change.
Testing time：28 days
Tested product：Anti-acne essence
Tested result：
Face's forehead fat secretion reduces by 20%, nose fat secretion and reduces the minimizing 10%, face of 21%, lip fat secretion
Cheek both sides fat secretion reduces 60%.
Summarize：Using containing 6% (water/ethanol/Propylene Glycol/pale flag (IRIS FLORENTINA) root extract/
Zinc sulfate/retinyl palmitate (compositionss two)) essence can soon reduce the sebum secretion of acne oily skin, returns
Restore skin sebum poised state.
4. internal test ----anti-inflammatory measure of merit
Testing program
Method：Human skin horn cell is studied using enzyme immunoassay (ELISA)；After induced inflammation, addition contains
There is 3% ((lecithin, butanediol, Salix alba (SALIX ALBA) bark extract, bone fat phenol, evergreen magnolia (MAGNOLIA
GRANDIFLORA) leaf extract) compositionss one) in essence culture 24 hours with 48 hours.
Testing time：24 hours/48 hours
Tested sample：Contain 3% ((lecithin, butanediol, Salix alba (SALIX ALBA) bark extract, bone fat phenol, lotus
Flower Magnolia denudata (MAGNOLIA GRANDIFLORA) leaf extract) compositionss one) anti-acne essence
Control sample：Essence containing the equal aspirin of equivalent
Tested result：
Suppress both prostaglandin PEG2 products almost without too big difference after 24 hours, after 48 hours, suppress prostaglandin
Both PEG2 samples decline 45%, it is seen that suppress inflammatory factor effect quite, suppress interleukin I L-8 to receive test sample after 48 hours
Product decline 35%, and control sample declines 12%；It can be seen that suppressing the tested samples of inflammatory factor interleukin I L-8 than control sample more preferably.
Summarize：Even if low concentration ((lecithin, butanediol, Salix alba (SALIX ALBA) bark extract, bone fat phenol,
Evergreen magnolia (MAGNOLIA GRANDIFLORA) leaf extract) compositionss one), also effectively can suppress Prostaglandin PGE2 with white
Interleukin IL-8 inflammatory factor is produced, the suitable aspirin of effect.
5th, internal test ----accelerate pox scar healing speed
Testing program
Method：By the asiaticoside/Madecassic acid/asiatic acid (compositionss three) containing 1% and without compositionss
Essence control sample test in 12 mouse skin pox scars.
Testing time：20 days
Tested sample：Asiaticoside/Madecassic acid/asiatic acid (compositionss three) anti-acne essence containing 1%
Control sample：(compositionss three) anti-acne essence is not contained
Tested result：
The speed that standard specimen pox scar containing 1% (compositionss four) is cured can shorten for 40% time, after treating 12 days, most
The pox scar very little for staying eventually and ten split-phase of pox scar healing in order, staying after treating 20 days with control sample that heals
Seemingly.
Summarize：
Above experimental data shows：The anti-acne essence that the present invention is provided has played the prevention of comprehensive small pox producing cause
With repair, from suppress 5-reductase → prevention sebum keratinization → suppression propionibacterium acness → Bergamot Mint Extract/receipts
Pore → anti-inflammatory factor → shortening pox scar healing time is held back, repairing effect is notable.
Claims (7)
1. a kind of anti-acne essence compositionss, including raw material and weight portion as follows：
One 3.0-5.0 of compositionss, two 5.0-8.0 of compositionss；Three 0.1-1.0 of compositionss；
Composition and percentage by weight in compositionss one be：Lecithin 9-11, butanediol 23-27, Salix alba bark extract 9-11,
Bone fat phenol 0.9-1.1, evergreen magnolia leaf extract 0.9-1.1, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 18-22, Propylene Glycol 28-32, pale flag root extract 4.4-
4.6th, zinc sulfate 0.4-0.6, retinyl palmitate 0.4-0.6, remaining is water；
Composition and percentage by weight in compositionss three be：Asiaticoside 36-44, Madecassic acid 36-44, asiatic acid
18-22.
2. anti-acne essence compositionss according to claim 1, it is characterised in that：
Composition and percentage by weight in compositionss one be：Lecithin 10, butanediol 25, Salix alba bark extract 10, bone fat
Phenol 1.0, evergreen magnolia leaf extract 1.0, remaining is water；
Composition and percentage by weight in compositionss two be：Ethanol 20, Propylene Glycol 30, pale flag root extract 4.5, zinc sulfate
0.5th, retinyl palmitate 0.5, remaining are water；
Composition and percentage by weight in compositionss three be：Asiaticoside 40, Madecassic acid 40, asiatic acid 20.
3. a kind of anti-acne essence, including raw material and percentage by weight as follows：
A groups：Plant sterol 1.4-1.6, octyl dodecanol lauroyl glutamate ester 1.4-1.6, three 0.1-1.0 of compositionss；
B groups：Tremella (TREMELLA FUCIFORMIS) polysaccharide 4.9-5.1, -1 9-11 of biological carbohydrate gum；One 3.0-5.0 of compositionss,
Two 5.0-8.0 of compositionss；
C groups：Butanediol 5.9-6.1, glycerol 2.9-3.1,1,2- pentanediol 2.9-3.1, two 0.09-0.11 of glycyrrhizic acid, arginine
0.11-0.13, carbomer 0.19-0.21, hyaluronate sodium 0.04-0.06, -73 0.009-0.011 of quaternary ammonium salt, remaining are to go
Ionized water.
4. the preparation method of the anti-acne essence described in claim 3, comprises the steps successively：
1), when the mixing of C groups raw material being heated to 85 DEG C, homogenizing, stirring make whole stock dispersions dissolvings, then persistently stir
It is cooled to 45 DEG C；
2) after C groups raw material reaches 45 DEG C, B groups raw material is sequentially added and homogenizing, stirring, persistently stirring cooling after the completion of dispersion
To 35 DEG C；
3) A group raw materials are heated to 45 DEG C, standby after stirring and dissolving；
4) after step 2 completes to be cooled to 35 DEG C, A groups raw material is added, after persistently stirring is cooled to 30 DEG C, filtering and discharging is
Into.
5. the preparation method of anti-acne essence according to claim 4, it is characterised in that described homogenizing is using at a high speed point
Scattered machine.
6. the preparation method of anti-acne essence according to claim 5, it is characterised in that step 1) in homogenizing time preferred
For 5Mins, mixing speed is preferably 600rpm.
7. the preparation method of anti-acne essence according to claim 6, it is characterised in that step 2) in homogenizing time preferred
For 1Mins, mixing speed is preferably 600rpm.
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Application publication date: 20170315 |