CN103202892A - Traditional Chinese medicine composition and skin care essence having acne treatment efficacy and preparation method of essence - Google Patents
Traditional Chinese medicine composition and skin care essence having acne treatment efficacy and preparation method of essence Download PDFInfo
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- CN103202892A CN103202892A CN2013101299336A CN201310129933A CN103202892A CN 103202892 A CN103202892 A CN 103202892A CN 2013101299336 A CN2013101299336 A CN 2013101299336A CN 201310129933 A CN201310129933 A CN 201310129933A CN 103202892 A CN103202892 A CN 103202892A
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Abstract
The invention provides acne treatment essence with acne treatment efficacy and a preparation method of the essence. The acne treatment water is prepared by taking traditional Chinese medicine theory of China as a basis, taking skin health as a purpose, taking a composite traditional Chinese medicine extract as a main efficacy additive and taking common substrate components in makeup as assistance. The acne treatment essence provided by the invention has bacteriostasis efficacy, and also has the efficacies of removing pathogenic heat from blood, promoting blood, reducing the stagnation, relieving itching, diminishing inflammation and the like. The composite traditional Chinese medicine extract is naturally green, healthy and safe, and can be widely applied to acne treatment cosmetics.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of have anti-acne and have the Chinese medicine composition and preparation method thereof of bacteriostasis efficacy concurrently and the Chinese medicine facial treatment repair that is prepared by said composition.
Background technology
Comedo is that hair follicle and sebaceous gland are blocked, and a kind of chronic inflammatory disease dermatoses that inflammation causes is common in the youth of both sexes of adolescence, mainly occur in face, cervical region, chest and back, shoulder and upper arm, form pimple, the traditional Chinese medical science claims " acne ", and the doctor trained in Western medicine name of disease is " acne ".The adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls the hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form the fat bolt and deposit.When these dyskeratosis cell aggregationes, when expanding, lower hopper just forms ripe acne.The bacterial decomposition that sebum is existed in the hair follicle produces fatty acid, and latter's hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, and the hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree on every side.The genesis mechanism of comedo, relevant with following three big factors:
(1) to the agnogenio property aggravation of androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction, causes sebum to produce and increase.
(2) propionibacterium acnes hypertrophy.This bacterium is formed for the hair follicle normal flora, and it is its effect machine matter with sebum, and makes it partly to be converted into free fatty.But propionibacterium acnes is the activating complement path also, produces two kinds of chemotactic factors at least, impels inflammation to take place.
(3) the capsular epithelium cell quantity increases, and tackness is arranged, and it is excessive to form the hair follicle tetention keratosis.Latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
At present there is following problem in popular product for resolving poxes on the market: 1, easily cause skin allergy, and big to skin irritation; 2, add chemical antibacterial and destroy the skin normal flora; 3, add hormones such as some banned substances such as chloromycetin; 4, add heavy metal substance.
Summary of the invention
The objective of the invention is to propose a kind of Chinese medicine composition with acne-removing.
A further object of the present invention is to propose a kind of preparation method of above-mentioned Chinese medicine composition.
The 3rd purpose of the present invention is to propose to utilize the purposes of the Chinese medicine extract that above-mentioned preparation method prepares.
The 4th purpose of the present invention is to propose a kind of skin care formulation that includes above-mentioned Chinese medicine extract.
Invention thinking of the present invention is:
The present invention utilizes advanced biotechnology, in conjunction with the traditional theory of Chinese medical science of China, Herba Artemisiae Scopariae, the Fructus Kochiae, Cortex Moutan, Galla Chinensis, Spina Gleditsiae, Spica Prunellae are effectively combined, form compound preparation, and with it as active component, be added in the anti-acne elite, make it have antibiotic, short infiltration, the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence, thus can effectively prevent and treat dissimilar acnes, give the new life of skin and vigor.
For realizing purpose of the present invention, the present invention adopts following concrete technical scheme:
A kind of Chinese medicine composition with acne-removing, the crude drug of described Chinese medicine composition is:
Herba Artemisiae Scopariae 20～30 weight portions, the Fructus Kochiae 20～30 weight portions, Cortex Moutan 10～20 weight portions, Galla Chinensis 10～20 weight portions, Spina Gleditsiae 10～20 weight portions, Spica Prunellae 10～20 weight portions.
A kind of preparation method of above-mentioned Chinese medicine composition, described method step is as follows:
(1) according to above-mentioned weight portion proportioning weighting raw materials;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 50 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,50 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time are concentrated into 0.2g/ml～0.5g/ml for the first time, get concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant, namely.
A kind of Chinese medicine extract with acne-removing, described extract is obtained by method for preparing.
Described Chinese medicine extract has purposes in the skin care formulation of acne-removing in preparation.
A kind of skin care formulation with acne-removing, described skin care formulation is prepared from by said extracted thing and skin care field adjuvant commonly used.
A kind of skin care compositions with acne-removing, described compositions is made up of the raw material of following mass percent:
A kind of above-mentioned skin protection preparation of compositions method processed, described method comprises the steps:
(1) water is heated to the water solublity Jojoba oil 80 ℃～90 ℃ dissolvings fully earlier;
(2) EDTA disodium, hyaluronate sodium, glycerol, allantoin, Aloe powder are added in the solution of step (1), be stirred to dissolving fully after being heated to 80 ℃～90 ℃; Add ammonium acryloyldime-thyltaurate// VP copolymer again and be stirred to dissolving fully;
(3) cool to below 40 ℃, add described antiseptic and Chinese medicine extract and stir, namely.
A kind of skin care formulation with acne-removing, described skin care formulation is made by said method.
Described skin care formulation is essence.
The preparation that above-mentioned raw materials and method prepare is the anti-acne essence.According to use approach difference, Chinese medicine composition of the present invention can utilize the simplest method to pulverize and make powder, pats skin, also can realize final technique effect.Or Chinese medicine extract also can be made into other external-use skin care preparations, as external facial cream, cleansing milk, water preparation or spray etc.But be not limited to above-mentioned dosage form, can be according to method preparation known in the skin care item industrial circle.
Essence of the present invention recommends using method to be: after clean of every day, essence is coated on the skin of pox, massage treats that essence slowly absorbs gently.
Useful result of the present invention:
Raw material of the present invention is all selected natural plant composition for use, and is non-stimulated to skin safe through experiment confirm, can fundamentally improve the skin microenvironment and reach the effect of curing acne, and have clearing away heat and cooling blood concurrently, blood circulation promoting and dispersing pathogen accumulation, antipruritic, press down effects such as fat antiinflammatory, can also alleviate and eliminate cicatrix pockmark etc.Raw material of the present invention obtains easily, preparation method is easy, green safety, and anti-acne is effective, is easy to be accepted by consumers in general, has good application prospects and market prospect.
Description of drawings
Fig. 1 anti-acne elite sample uses back skin oil and fat changes of contents situation;
Fig. 2 anti-acne elite sample uses the situation of change of back skin oil and fat increment rate;
Fig. 3 anti-acne elite sample uses the relative increment rate of back skin oil and fat.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.
Preparation raw material of the present invention source sees Table 1:
Table 1
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) take by weighing each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 30g, Fructus Kochiae 20g, Cortex Moutan 10g, Galla Chinensis 20g, Spina Gleditsiae 10g, Spica Prunellae 20g.
(2) percent by volume is 75% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:20, and 60 ℃ of heated and stirred 1 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10,60 ℃ of heated and stirred 30min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.2g/ml, gets concentrate;
(3) redissolve according to adding propylene glycol in the mass ratio g/g concentrate that to be 1:1 obtain to step (2), sucking filtration, 3000 rev/mins of centrifuging and taking supernatant, namely.
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) take by weighing each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 20g, Fructus Kochiae 30g, Cortex Moutan 15g, Galla Chinensis 10g, Spina Gleditsiae 15g, Spica Prunellae 10g.
(2) percent by volume is 80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10, and 70 ℃ of heated and stirred 2 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:20,70 ℃ of heated and stirred 60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.5g/ml, gets concentrate;
(3) redissolve according to adding propylene glycol in the mass ratio g/g concentrate that to be 1:2 obtain to step (2), sucking filtration, 5000 rev/mins of centrifuging and taking supernatant, namely.
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) take by weighing each raw material of Chinese medicine medicine according to following compositions:
Herba Artemisiae Scopariae 25g, Fructus Kochiae 25g, Cortex Moutan 20g, Galla Chinensis 15g, Spina Gleditsiae 20g, Spica Prunellae 15g.
(2) percent by volume is 80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:15, and 50 ℃ of heated and stirred 1.5 hours are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:15,50 ℃ of heated and stirred 40min, filter the second time filtrate; Filtrate and filtrate mixing for the second time for the first time, rotary evaporation is concentrated into 0.3g/ml, gets concentrate;
(3) redissolve according to adding propylene glycol in the mass ratio g/g concentrate that to be 1:1.5 obtain to step (2), sucking filtration, 4000 rev/mins of centrifuging and taking supernatant, namely.
The preparation of embodiment 4 essences of the present invention
Raw material and proportioning (mass percent) see Table 2:
Table 2
Preparation method:
(1) first with water solublity Jojoba oil heating for dissolving with deionized water, 80 ℃ of heating-up temperatures;
(2) EDTA disodium, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined be heated to 80 ℃ in the solution of step (1) after stirring and dissolving; Add AVC, stir, it is dissolved fully.
(3) be cooled to below 40 ℃, add antiseptic and Chinese medicine extract, stir, namely get anti-acne elite finished product.
The preparation of embodiment 5 essences of the present invention
Raw material and proportioning (mass percent) see Table 3
Table 3
Preparation method:
(1) first with water solublity Jojoba oil heating for dissolving with deionized water, 90 ℃ of heating-up temperatures;
(2) EDTA disodium, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined be heated to 90 ℃ in the deionized water after stirring and dissolving; Add AVC, stir, it is dissolved fully.
(3) be cooled to below 40 ℃, add antiseptic and Chinese medicine extract, stir, namely get anti-acne elite finished product.
The preparation of embodiment 4 essences of the present invention
Raw material and proportioning (mass percent) see Table 4
Table 4
Preparation method:
(1) first with water solublity Jojoba oil heating for dissolving with deionized water, 85 ℃ of heating-up temperatures
(2) EDTA disodium, hyaluronate sodium, glycerol, allantoin, Aloe powder are joined be heated to 85 ℃ in the deionized water after stirring and dissolving, add AVC, stir, it is dissolved fully;
(3) be cooled to below 40 ℃, add antiseptic and Chinese medicine extraction liquid, stir, namely get anti-acne elite finished product.
Effect experiment of the present invention
One, anti-acne elite anti-acne effect
1, inhibition zone
1) experimental principle:
On inoculating for examination culture of strains base, impose quantitative sample, utilize the scattering and permeating effect of sample in agar culture medium, reach certain limit through sample infiltration diffusion behind the certain hour.In the scope that Mlc reaches, the growth of indicator bacteria just is suppressed, and produces an aseptic transparent region, is called inhibition zone.Under certain condition with certain limit in, the diameter of inhibition zone and the logarithm of sample concentration be functional relationship linearly.Utilize this principle, can compare the size of antibacterial virulence, or the working sample content of effective.
2) inhibition zone of external bacteriostatic experiment the results are shown in Table 5:
Table 5 Chinese medicine extraction liquid and erythromycin benzoyl peroxide MIC measurement result (mg/ml)
| Group | Propionibacterium acnes | Staphylococcus aureus | Staphylococcus epidermidis | The Fructus Citri |
| Embodiment | ||||
| 1 extract | 27.96 | 30.25 | 16.42 | 66.35 |
| Erythromycin | 12.71 | 30.25 | 30.42 | 66.35 |
3) result
From this experiment as can be seen, embodiment 1 extract and erythromycin benzoyl peroxide all have bacteriostasis in various degree, but the bacteriostasis of the two there were significant differences.Embodiment 1 extract is 7.96mg/ml to the MIC of propionibacterium acnes, and fungistatic effect is the strongest, and the MIC of staphylococcus epidermidis and staphylococcus aureus is respectively 16.42,30.25, is 66.35 to the staphylococcic MIC of Fructus Citri Limoniae, and its bacteriostasis is the most weak; The erythromycin benzoyl peroxide is best to the fungistatic effect of staphylococcus epidermidis, staphylococcus aureus, the MIC measurement result is 30.42,30.25mg/ml, all low than the treatment group to Fructus Citri Limoniae staphylococcus bacteriostasis, MIC value 66.35mg/ml, bacteriostasis to propionibacterium acnes is the poorest, the MIC value is 12.71mg/ml, and curative effect is starkly lower than the treatment group.The Chinese medicine extract of the embodiment of the invention 1 preparation has bacteriostasis efficacy preferably as can be seen from the results, and it is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
2, product control oil effect
1) experimental principle
Human experimentation, the crowd forms test population by particular experiment, test subject makes the variation of the skin oil and fat content before and after (and cosmetic industry composition) of applying some make up, thus determine cosmetics (or functional component) press down the fat effect.
2) experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
Sample: embodiment 4 anti-acne essences.
Blank: as to be tried the position and do not use any cosmetics.
3) experiment crowd
The experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If there are 2 people untoward reaction to occur, then stop test during this time; The result does not find untoward reaction.
4) experimental technique
1. select experimenter's forehead (branch left and right sides two parts) cycle labeling successively: tried region samples group and blank zone;
2. the technical staff uses the skin oil and fat tester
Averaging in test test position 3-5 time, is designated as initial value.
3. test the position the experimenter and smear sample, use the anti-acne elite.
4. the experimenter make continuously applied some make up one hour, two hours, four hours after, use the skin oil and fat tester by the technical staff
Measure 3-5 time, average.
5. add up the numerical value that records, analyze its skin oil and fat changes of contents rule.
5) interpretation of result
Fat content changes
The fat content variation is reflected in test period Experimental Area fat content change with time.Its value is more big, and fat content is more big, otherwise fat content is more little.
As shown in Figure 1, sample sets is compared with the blank group after using 1 hour, and diversity is obvious; Sample used in 4 hours, and the fat content of sample sets is starkly lower than blank group.
The oils and fats increment rate changes
Oils and fats increment rate=(sample sets fat content-initial fat content)/initial fat content
As shown in Figure 2, in test period, tried the position after sample uses 1 hour, compare with initial value, skin oil and fat secretion increment rate is starkly lower than blank group, and is lower than blank group always.
Press down the fat rate
The relative increment rate of oils and fats namely presses down fat rate=(sample sets fat content-blank group fat content)/blank group fat content; This value is more little, and it is more obvious to illustrate that the relative blank sample of test specimen presses down the fat effect.
As shown in Figure 3, in test period, tried after the position uses sample, it presses down the fat rate is negative value always.
6) conclusion
After using sample, the fat secretion amount of being tried the position be starkly lower than do not smear sample be subjected to illustrate that product has the ability that skin oil and fat is secreted that suppresses in the examination zone.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
3, prevent that pockmark from telling on
1) experimental principle
Pockmark a kind of reparation reaction that to be body produce tissue injury, when the damage of skin reaches corium or large-area skin blemish deeply, the epidermis at this position can not be regenerated, will be by the corium fabric cell, collagen and proliferation of vessels replace, and pockmark so just occurred.The pox scar is because the extruding of infection inflammation or external force forms, and the inflammatory response of Skin Cell has caused the destruction of skin histology and to injure the collagen protein of corium too many, has caused the generation of cicatrix.Therefore improve the skin environment, keep skin elasticity, guarantee that collagen protein not by excessive degradation, can reduce the generation of cicatrix.
(Matrix Metalloproteinases 1 MMP-1) is the key enzyme of degrade collagen albumen to matrix metalloproteinase 1, and the activity that suppresses MMP-1 can effectively reduce the collagen protein amount that is degraded, thereby reduces the generation of cicatrix.Therefore the effect that cicatrix is produced of the active reaction plant functional component by vitro inhibition matrix metalloproteinase-1(MMP-1).
Set up MMP-1 enzyme reaction experiment porch, based on this platform, under the prerequisite of destructive enzyme reaction system not, add the plant extract functional component, detect the variation of product fluorescence intensity by the enzyme reaction system, the variation of reflection enzyme activity indirectly, thus reflect that this plant extraction liquid functional component is to the influence of MMP-1 activity.
2) experimental procedure
1. solvent preparation:
(1) preparation buffer (50mmol/L HEPES, 0.12mol/L NaCl, 10mmol/L CaCl2,20 μ mol/L ZnSO4,0.05%Brij-35, pH=7.5),
(2) the MMP-1 proenzyme is standby with buffer gradient dilution to 0.22 μ g/100 μ L;
(3) fluorogenic substrate DQ-gelatin is standby with buffer gradient dilution to 0.20 μ g/100 μ L;
(4) the zymoexcitator APMA of adding 30mmol in the 0.1mol/L of 1L NaOH solution, it is standby to form APMA storing solution (30mmol/L);
(5) sample (embodiment 1 preparation) is mixed with certain density solution for standby;
2.MMP-1 the activation of proenzyme: the volume ratio (MMP:APMA) of MMP-1 proenzyme solution (0.22 μ g/100 μ L) and APMA solution (30mmol/L) being pressed 10:1 is mixed, and hatches the 45min activation at 37 ° of C;
3. application of sample: MMP-1 solution (concentration has been reduced to 0.20 μ g/100 μ L) the 40 μ L that get after the activation add in the 96 hole ELISA Plate, add sample (embodiment 1 preparation) solution 8 μ L again, fluorogenic substrate DQ-gelatin solution (0.20 μ g/100 μ L) 52 μ L, making the end reaction system is 100 μ L;
Table 6 vitro inhibition MMP-1 experiment application of sample table
4. constant temperature is hatched: the 96 hole ELISA Plate that will finish application of sample are put into 37 ℃ of incubator constant temperature and are hatched 600s;
5. experimental result detects
(1). be 460nm in excitation wavelength before the reaction, emission wavelength is to detect the fluorescence intensity for the treatment of the measuring plants functional component under the testing conditions of 520nm;
(2). detect the fluorescence intensity of whole reaction system after reaction system stops to hatch immediately with Bio-Red FLx-800 fluorescence microplate reader, excitation wavelength is 460nm, and emission wavelength is 520nm.
6. Data Processing in Experiment
MMP-1 suppresses percent (%)=[1-(A
1-A
2)/Ao] * 100%
A
1The fluorescence intensity of sample (embodiment 1 preparation) inhibition group is added in-representative
A
2The fluorescence intensity of-representative sample (embodiment 1 preparation) self
Ao-the represent fluorescence intensity of blank group
It is more remarkable to the active inhibition of MMP-1 to suppress this kind of plant functional component of the more big expression of percent.
3) experimental result
Chinese medicine extraction liquid is 97.62% to the maximum inhibition of MMP-1 after tested.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
Conclusion: this product prevents that pockmark from producing and the desalination pockmark has positive effect.
4, anti-acne effect clinical data and method
4.1 data and method
4.1.1 case is selected
200 routine patients are divided into treatment group, matched group at random.100 examples are organized in treatment, 13 years old～33 years old age, average 20.5 years old; Man's 40 examples, women 60 examples; The course of disease 2 months～10 years, average 3.1 years; Wherein acne, papular type 58 examples, pustule type 30 examples, pockmark type 12 examples.Matched group 100 examples, 14 years old～35 years old age, average 21.5 years old; Man's 37 examples, women 63 examples; The course of disease 2 months～12 years, average 3.6 years; Wherein acne, papular type 60 examples, pustule type 27 examples, pockmark type 12 examples.2 groups of patient's sexes, age, courses of disease are learned processing by statistics, and difference not statistically significant (P＞0.05) has comparability.
4.1.2 Therapeutic Method: treatment group external embodiment 4 preparation anti-acne elite, every day 2 times, 4 weeks were 1 course for the treatment of.Matched group is with erythromycin benza gel every day 2 times, 4 weeks of the course for the treatment of.Observing skin lesion improves degree and adds up clinical efficacy.
4.1.3 clinical efficacy
Skin lesion counting * 100% before curative effect=(skin lesion counting before the treatment-treatment back skin lesion counting)/treatment
Recovery from illness: skin lesion disappears more than 90%, and a little pigmentation is only arranged;
Produce effects: skin lesion disappears 60%～90%, sx;
Effectively: skin lesion disappears 20%～60%, doing well,improving;
Invalid: skin lesion disappears＜and 20%, clinical symptoms is not improved;
Total effective rate=cure rate+obvious effective rate
Onset time is judged: the natural law that sx, deflorescence reach more than 20% after the medication is onset time.
Treatment group 55 examples of fully recovering, produce effects 42 examples, total effective rate is 97.0%, matched group 31 examples of fully recovering, produce effects 42 examples, total effective rate is 73.0%, the treatment group is apparently higher than matched group.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
Table 7 treatment group and matched group curative effect be (%) relatively
| Group | The example number | Recovery from illness | Produce effects | Invalid | Cure rate | Effective percentage |
| The |
100 | 55 | 42 | 3 | 55.0% | 97.0% |
| Matched |
100 | 31 | 42 | 27 | 31.0% | 73.0% |
4.1.4 onset time relatively: treatment group: 1d～3d onset patient 42 examples, 3d～7d onset 30 examples,＞7d onset 28 examples; Matched group: 1d～3d onset patient 29 examples, 3d～7d onset 27 examples,＞7d onset 46 examples.Treatment group and matched group compare, and onset time obviously shifts to an earlier date.It is identical that the inventor repeats above-mentioned experimental result with other embodiment preparing products.
Table 8 matched group and the onset time comparison for the treatment of group
| Group | The |
1～3d | 3～7d | ﹥7d |
| The |
100 | 42 | 30 | 28 |
| Matched |
100 | 29 | 27 | 46 |
Claims (9)
1. the Chinese medicine composition with acne-removing is characterized in that, the crude drug of described Chinese medicine composition is:
Herba Artemisiae Scopariae 20～30 weight portions, the Fructus Kochiae 20～30 weight portions, Cortex Moutan 10～20 weight portions, Galla Chinensis 10～20 weight portions, Spina Gleditsiae 10～20 weight portions, Spica Prunellae 10～20 weight portions.
2. the preparation method of the described Chinese medicine composition of claim 1 is characterized in that, described method step is as follows:
(1) according to the described weight portion proportioning of claim 1 weighting raw materials;
(2) percent by volume is 75%～80% ethanol extraction twice, for the first time extracts crude drug with ethanol mass volume ratio g/ml is 1:10～1:20, and 50 ℃～70 ℃ heated and stirred 1～2 hour are filtered the inferior filtrate of winning; For the second time extract crude drug with ethanol mass volume ratio g/ml is 1:10～1:20,50 ℃～70 ℃ of heated and stirred 30min～60min, filter the second time filtrate; Filtrate and filtrate mixing for the second time are concentrated into 0.2g/ml～0.5g/ml for the first time, get concentrate;
(3) according to adding propylene glycol or butanediol in the mass ratio concentrate that to be 1:1～1:2 obtain to step (2), sucking filtration, 3000～5000 rev/mins of centrifuging and taking supernatant, namely.
3. the Chinese medicine extract with acne-removing is characterized in that, described extract is prepared by the described method of claim 2.
4. the described Chinese medicine extract of claim 3 has purposes in the skin care formulation of acne-removing in preparation.
5. the skin care formulation with acne-removing is characterized in that, described skin care formulation is prepared from by the described extract of claim 3 and skin care field adjuvant commonly used.
6. the skin care compositions with acne-removing is characterized in that, described compositions is made up of the raw material of following mass percent:
7. the described skin protection of claim 6 a preparation of compositions method processed is characterized in that described method comprises the steps:
(1) water is heated to the water solublity Jojoba oil 80 ℃～90 ℃ dissolvings fully earlier;
(2) EDTA disodium, hyaluronate sodium, glycerol, allantoin, Aloe powder are added in the solution of step (1), be stirred to dissolving fully after being heated to 80 ℃～90 ℃; Add ammonium acryloyldime-thyltaurate// VP copolymer again and be stirred to dissolving fully;
(3) cool to below 40 ℃, add described antiseptic and Chinese medicine extract and stir, namely.
8. the skin care formulation with acne-removing is characterized in that, described skin care formulation is made by the described method of claim 7.
9. the skin care formulation with acne-removing according to claim 8 is characterized in that, described skin care formulation is essence.
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| CN104940048A (en) * | 2014-03-26 | 2015-09-30 | 无锡康健因生命科学技术研究院有限公司 | Scar-removing essence |
| CN105194286A (en) * | 2015-05-28 | 2015-12-30 | 孟宏 | Radiation-proof external skin-care composition and essence with skin barrier repair effect and preparation method thereof |
| CN105919863A (en) * | 2016-05-30 | 2016-09-07 | 皖南医学院 | Acne removing and skin beautifying cream rich in extracts of natural ingredients and preparation method thereof |
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| CN105194286B (en) * | 2015-05-28 | 2019-03-01 | 孟宏 | Have effects that radiation protection and repair the external skin-care composition of skin barrier, essence and preparation method thereof |
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| CN105919863B (en) * | 2016-05-30 | 2018-08-21 | 皖南医学院 | Beautiful skin frost of a kind of anti-acne rich in natural component extract and preparation method thereof |
| CN105919876A (en) * | 2016-06-12 | 2016-09-07 | 马殿伟 | Traditional Chinese medicine composition containing cerasusssp and applied to acne removing cosmetics |
| CN106176523A (en) * | 2016-08-10 | 2016-12-07 | 西宁琉璃王生物科技有限公司 | For making compositions of essence containing yak milk composition and preparation method thereof |
| CN106491439A (en) * | 2016-11-28 | 2017-03-15 | 上海珍芙生物科技有限公司 | A kind of anti-acne essence compositionss, anti-acne essence and preparation technology |
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