CN110279602A - Skin repair composition, preparation method, and the application in cosmetics - Google Patents
Skin repair composition, preparation method, and the application in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention relates to a kind of skin repair compositions, preparation method, and the application in cosmetics, the raw material components of the skin repair composition include: Cer NP 1-10 parts by weight, hydrolecithin 5-15 parts by weight, hydrogenated olive oil unsaponifiable matter 5-15 parts by weight, strigose oat extract 5-15 parts by weight, tetrahydro methylpyrimidine carboxylic acid 10-20 parts by weight, Gotu Kola P.E 5-15 parts by weight, hydroxyethyl piperazine ethane sulfonic acid 0.5-2 parts by weight.Skin repair composition of the present invention cooperates between various components and plays a role, internally can be improved the self-repairing capability and cutaneous immunisation ability of cell；Epidermal thickness can externally be increased, repair skin barrier, i.e., the present invention can play the repairing effect to skin in terms of inside and outside two simultaneously, thus skin repair significant effect, the present invention are safe and non-stimulating, are easy to add in the formula system of the various dosage forms of cosmetics.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of skin repair composition, preparation method, Yi Ji
Application in cosmetics.
Background technique
Skin is the maximum organ of human body, mainly has two aspect important function: on the one hand preventing moisture in vivo, electrolysis
Matter, other substances are lost；On the other hand the intrusion of extraneous harmful substance is prevented.
It is shown according to investigation, there is the consumer of skin problem puzzlement to be up to 20% for China.These skin problem majorities are
Due to caused by skin damage.The main reason for skin damage, there is 4 kinds: 1. environmental factor: such as pollution, climate change, solarization, temperature
Degree variation etc.；2. skin care is improper: such as abuse cosmetics, excessively cleaning, excessively makeup；3. life style: such as the pungent thorn of diet
Sharp, excessive drinking of smoking, operating pressure are big, and daily life system is irregular etc.；4. iatrogenic factors: such as external application dripping of irritant drugs, long-term outer
With invasive treatment such as glucocorticoid ointment and laser etc..Therefore, the skin care item that can repair skin injury become consumer
New pursuit.
The cardinal symptom of skin damage is that epidermis is thinning, sometimes visible vessels；In temperature change or the thorn of extreme temperature
Skin is easy rubescent under swashing；It is sensitive to environment, seasonal variations, cosmetics stimulation, it is also easy to produce inflammation, allergy；Renewal speed is slack-off,
Skin has been easy bits, intense darkness without light pool etc..
It is mainly carried out on the market from the following aspects for the skin-protection product of skin repair at present:
1. reducing stimulation, to anti-inflammatory.Product is reduced to the stimulation of skin and addition anti-inflammatory component.Disadvantage: only subtract
Few exogenous stimulation, has no any help for skin internal repair.
2. supplementing the nutrients, repairing skin barrier.It supplements the nutrients to cuticula, helps cuticula reparation.Disadvantage: only
It is the reparation for cuticula, deeper reparation cannot be carried out to skin.
3. promoting cell differentiation, repairing skin barrier.Some compositions that can promote cell differentiation are added, skin is promoted
It updates.Disadvantage: belonging to exogenous help, has very strong dependence, skin can not really be repaired by merely facilitating cell differentiation
Skin.
It can be seen that technology on the market not can be carried out and take into account both for exogenesis progress skin repair at present, and
It is non-from it is inside and outside because it is upper it is common solve the problems, such as, cannot improve the resilience of skin itself, transfer skin itself strength, make skin
Become more strong.
Summary of the invention
It is an object of that present invention to provide the skin repair composition that a kind of internal cause, external cause are taken into account, the skin repair combination
Object internally can be improved the self-repairing capability and cutaneous immunisation ability of cell；Epidermal thickness can externally be increased, repair skin
Skin barrier, the i.e. present invention can play the repairing effect to skin, thus skin repair significant effect in terms of inside and outside two simultaneously,
The present invention is safe and non-stimulating, is easy to add in the formula system of the various dosage forms of cosmetics.
The technical solution of the present invention is as follows:
A kind of skin repair composition, by weight, raw material components include:
Cer NP, 1-10 parts by weight；
Hydrolecithin, 5-15 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 5-15 parts by weight；
Strigose oat extract, 5-15 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10-20 parts by weight；
Gotu Kola P.E, 5-15 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.5-2 parts by weight.
Further, the skin repair composition, by weight, raw material components include:
Cer NP, 3-7 parts by weight；
Hydrolecithin, 8-12 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 8-12 parts by weight；
Strigose oat extract, 8-12 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10-15 parts by weight；
Gotu Kola P.E, 8-12 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.8-1.5 parts by weight.
Further, the skin repair composition, by weight, raw material components include:
Cer NP, 5 parts by weight；
Hydrolecithin, 10 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 10 parts by weight；
Strigose oat extract, 10 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10 parts by weight；
Gotu Kola P.E, 10 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 1 parts by weight.
The preparation method of the skin repair composition, includes the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, heats while stirring, then drops
Temperature obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid is stirred to dissolve completely, obtains component B；
(3) component A is added in Xiang Zufen B, stirs evenly to get the skin repair composition.
Further, in step (1), the speed of the stirring is 20-100r/min, and the temperature that is heated to is 85-90
DEG C, it is described to be cooled to 45 DEG C or less.
Further, in step (2), the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, centella are extracted
The mass ratio of object, the gross mass of four kinds of raw materials of hydroxyethyl piperazine ethane sulfonic acid and water is 1:0.5-1.7.
Further, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, ethoxy piperazine
The gross mass of four kinds of raw materials of piperazine ethane sulfonic acid and the mass ratio of water are 1:1.3.
Further, in step (3), the speed of the stirring is 20-100r/min, and the time of the stirring is 10-
15min。
A kind of cosmetics including the skin repair composition, addition of the skin repair composition in cosmetics
Amount is 2-5wt%.
Application of the skin repair composition in cosmetics.
The invention has the benefit that
1, skin repair composition of the present invention, is not saponified using Cer NP, hydrolecithin, hydrogenated olive oil
Object, strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E and hydroxyethyl piperazine ethane sulfonic acid are raw material
And carry out suitable weight proportion, wherein Cer NP is to pass through the chemical combination in conjunction with amido bond with fatty acid by sphingosinols
Object is N- stearoyl-phytosphingosine.Skin moisturizing, reconstituted cell bonding can be played in the intercellular lipid of skin barrier
Property, promote the update of skin natural containment, and repair the dry effect with damaged skin rapidly；Hydrolecithin and cell
The structure of phospholipid of film is quite similar, is the active constituent of biological cell, plays an important role in cell permeability and new old Dai Xinzhong；
Hydrolecithin can maintain the normal water balance of skin, prevent from peeling, increase skin softness, thicken cuticula, and can
The stimulation of product is reduced, allergy probability is reduced, plays a significant role in terms of repairing skin barrier；Hydrogenated olive oil unsaponifiable matter
With excellent infiltration and lubricating ability, facilitate the drying and problem of rough of alleviating skin, while increasing the pliability of skin；
Strigose oat contains the substances such as a large amount of vitamin, folic acid, saponin(e, amide, glucan, minerals, have anti-inflammatory, it is antipruritic and
Mitigate the effect of erythema；Tetrahydro methylpyrimidine carboxylic acid is also known as " Facultative Halophiles extract liquor ", also referred to as Ectoin, from high thermophilic salt
Bacterium, with high salt, high temperature, high ultraviolet radiation extreme condition under, so that Halophiles is escaped injury, can effectively promote Skin Cell
Immune protection ability increases cell repair ability, allows the skin to the invasion for effectively antagonizing microorganism and anaphylactogen；Centella is umbrella
The herb of shape section plant Centella asiatica, containing including Asiaticoside, thankuniside, isothankuniside, madecassoside, motor product
A variety of Triterpenoids including oxalic acid and asiatic acid are avenged, in addition, also recklessly containing meso inositol, centellose, wax, class
The ingredients such as radish element class, chlorophyll, have effects that clearing heat and promoting diuresis, promoting blood circulation and hemostasis, removing toxicity for detumescence；Hydroxyethyl piperazine ethane sulfonic acid
An effectively biological buffer, maintain to promote while biological enzymatic structure and the function of active constituent activity at
Point absorption, can cutin-softening, leniently promote the old horn cell of skin epidermis to peel off, enable skin soft, smooth.
2, skin repair composition of the present invention has synergistic effect between various components, and test proves, skin of the present invention
Skin remediation composition can make cell itself stress protect speed, self-healing repair speed promoted 2-3 times；Can effective protection it is bright
Ge Hansi cell, protects it from the injury of environmental stimuli, to enhance skin immune system, improves skin resistance；Can have
Effect increases epidermal thickness；There is good inhibitory effect for the generation of tetra- kinds of TNF-α, PGE 2, IL-6, IL-8 inflammatory factors；
Epidermal renewal can be effectively facilitated；Reduce average percutaneous moisture loss；Improve general red and pruritis.Therefore, of the present invention
Skin repair composition internally can be improved the self-repairing capability and cutaneous immunisation ability of cell；Table can externally be increased
Skin thickness repairs skin barrier, i.e. the present invention can play the repairing effect to skin, thus skin in terms of inside and outside two simultaneously
Repairing effect is significant, and the present invention is safe and non-stimulating, is easy to add in the formula system of the various dosage forms of cosmetics, thus has weight
The realistic meaning and extensive market prospects wanted.
Detailed description of the invention
Fig. 1: epidermal thickness is promoted to increase the test control group of effect
Fig. 2: the test for promoting epidermal thickness to increase effect is handled using 2% embodiment 4
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
1g is represented in following embodiment with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of skin repair compositions, and by weight, raw material components include:
Cer NP, 5 parts by weight；
Hydrolecithin, 10 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 10 parts by weight；
Strigose oat extract, 10 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10 parts by weight；
Gotu Kola P.E, 10 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 1 parts by weight.
Further, a kind of method preparing the skin repair composition is provided, is included the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, under 20r/min mixing speed, is added
Heat to temperature is 85 DEG C, is then cooled to 45 DEG C, obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyethyl piperazine
The gross mass of four kinds of raw materials of ethane sulfonic acid and the mass ratio of water are 1:0.5, are stirred to dissolve completely, obtain component B；
(3) component A is added in Xiang Zufen B, with the mixing speed stirring 15min of 20r/min to get the skin repair group
Close object.
Embodiment 2
The present embodiment provides a kind of skin repair composition, raw material components include:
Cer NP, 1 parts by weight；
Hydrolecithin, 5 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 5 parts by weight；
Strigose oat extract, 5 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 15 parts by weight；
Gotu Kola P.E, 12 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.8 parts by weight.
Further, a kind of method preparing the skin repair composition is provided, is included the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, under 100r/min mixing speed,
Being heated to temperature is 90 DEG C, is then cooled to 40 DEG C, obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyethyl piperazine
The gross mass of four kinds of raw materials of ethane sulfonic acid and the mass ratio of water are 1:1.7, are stirred to dissolve completely, obtain component B；
(3) component A is added in Xiang Zufen B, with the mixing speed stirring 10min of 100r/min to get the skin repair
Composition.
Embodiment 3
The present embodiment provides a kind of skin repair composition, raw material components include:
Cer NP, 7 parts by weight；
Hydrolecithin, 12 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 12 parts by weight；
Strigose oat extract, 8 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10 parts by weight；
Gotu Kola P.E, 8 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 1.5 parts by weight.
Further, a kind of method preparing the skin repair composition is provided, is included the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, under 40r/min mixing speed, is added
Heat to temperature is 90 DEG C, is then cooled to 40 DEG C, obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyethyl piperazine
The gross mass of four kinds of raw materials of ethane sulfonic acid and the mass ratio of water are 1:3, are stirred to dissolve completely, obtain component B；
(3) component A is added in Xiang Zufen B, with the mixing speed stirring 12min of 40r/min to get the skin repair group
Close object.
Embodiment 4
The present embodiment provides a kind of skin repair composition, raw material components include:
Cer NP, 10 parts by weight；
Hydrolecithin, 15 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 15 parts by weight；
Strigose oat extract, 12 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 20 parts by weight；
Gotu Kola P.E, 5 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 2 parts by weight.
Further, a kind of method preparing the skin repair composition is provided, is included the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, under 60r/min mixing speed, is added
Heat to temperature is 90 DEG C, is then cooled to 30 DEG C, obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyethyl piperazine
The gross mass of four kinds of raw materials of ethane sulfonic acid and the mass ratio of water are 1:1, are stirred to dissolve completely, obtain component B；
(3) component A is added in Xiang Zufen B, with the mixing speed stirring 15min of 60r/min to get the skin repair group
Close object.
Embodiment 5
The present embodiment provides a kind of skin repair composition, raw material components include:
Cer NP, 3 parts by weight；
Hydrolecithin, 8 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 8 parts by weight；
Strigose oat extract, 15 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 12 parts by weight；
Gotu Kola P.E, 15 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.5 parts by weight.
Further, a kind of method preparing the skin repair composition is provided, is included the following steps:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, under 80r/min mixing speed, is added
Heat to temperature is 90 DEG C, is then cooled to 35 DEG C, obtains component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyl second
Base piperazine ethanesulfonic acid, the strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, hydroxyethyl piperazine
The gross mass of four kinds of raw materials of ethane sulfonic acid and the mass ratio of water are 1:5, are stirred to dissolve completely, obtain component B；
(3) component A is added in Xiang Zufen B, with the mixing speed stirring 15min of 80r/min to get the skin repair group
Close object.
Comparative example 1
Difference with embodiment 5, which is only that, removes Cer NP.
Comparative example 2
Difference with embodiment 5, which is only that, removes hydrolecithin.
Comparative example 3
Difference with embodiment 5, which is only that, removes hydrogenated olive oil unsaponifiable matter.
Comparative example 4
Difference with embodiment 5, which is only that, removes strigose oat extract.
Comparative example 5
Difference with embodiment 5, which is only that, removes tetrahydro methylpyrimidine carboxylic acid.
Comparative example 6
Difference with embodiment 5, which is only that, removes Gotu Kola P.E.
Comparative example 7
Difference with embodiment 5, which is only that, removes hydroxyethyl piperazine ethane sulfonic acid.
Experimental example
One, security test
Skin patch test
50 people of test number, meets subject's standard.It is small that skin repair composition in embodiment is put into spot tester
Interior, dosage are about 0.020-0.025mL.Control wells are blank control (not setting any substance), will be tried added with the spot of tested material
Device is pasted on the back or forearm song side of subject with low sensitization adhesive tape, is gently pressed with palm and is allowed to equably be pasted on skin,
Continue for 24 hours.After removing tested material spot tester 30min (after impression disappearance after), for 24 hours with 48h according to the form below standard sight skin
Skin reaction, and observation is recorded as a result, being shown in Table 1,2.
1 skin closure patch test dermoreaction grade scale of table
2 1-5 human skin patch test result of the embodiment of the present invention of table
Human skin patch test the result shows that, skin repair composition of the present invention be it is non-stimulated.
Two, efficacy test
1, promote the experimental study of cell self-regeneration effect
Heat shock protein is one of molecule most ancient in organism, is a kind of important protective protein.Heat shock protein
The protein of damage can be stablized, repair, being removed to the white folder function that can support protein.When organism is by very big ring
Border pressure, such as when high temperature, stimulation, ultraviolet generation damage, a large amount of heat shock protein can be synthesized, so that each cell be helped to tie up
Hold normal physiological activity.Therefore the content of the heat shock protein in detection cell can react the reparation speed of organism itself
Degree.
Test method: testing in vitro, using human keratinous formation cell model, test group concentration 2%
Embodiment 1-5, comparative example 1~7 are handled, and control group is not processed, using hsp72/73 Immunohistochemical Method into
Row analysis, observes its fluorescence intensity.Test result is shown in Table 3.
The test result of the promotion cell self-regeneration effect of table 3
Test result shows to add that 1~5 skin repair composition of the embodiment of the present invention makes cell itself stress protect speed
Degree, self-healing repair speed and improve 2-3 times, hence it is evident that are better than comparative example skin repair composition, illustrate that the present composition has
The significant effect for promoting cell self-regeneration.
2, enhance the experimental study of cutaneous immunisation power effect
Langerhans cell is the antigen presenting cell of skin, can be identified, the antigen of combination and processing intrusion skin, and handle
Antigen sends T cell to, is the important cells of skin immune function controlling.In Contact hyper sensitization, viral infection resisting, repel heteroplastic transplantation
It plays a significant role in the immunosurveillance of tissue.
Test method: selecting the age between 25-35 years old, and healthy volunteer 10, to regulation one 2 on the inside of its forearm
The region of × 2cm carries out UV irradiation (intensity 1.5MED) to the region, the embodiment 1-5 of test group concentration 2%, comparison
Example 1~7 is handled, and control group is not processed, and untreated fish group is to irradiate without UV.It measures after 2 weeks and is compared with blank.
Measurement method is ATPase tissue staining slice.Test result is shown in Table 4.
The test result of the enhancing cutaneous immunisation power effect of table 4
Test result shows 1~5 skin repair composition effective protection of embodiment of the present invention Langerhans cell, makes
It is from the injury of environmental stimuli, and protecting effect is substantially better than comparative example 1~7, illustrates that the present invention can enhance cutaneous immunisation
System keeps skin resistance more preferable.
3, epidermal thickness is promoted to increase the experimental study of effect
Epidermal thickness is thinning when skin damage, and skin is more vulnerable to extraneous infringement, generates skin problem.When epidermal thickness increases
Added-time, for extraneous power of resisting, also mutually strain is strong, and the barrier function of itself is reinforced, many skin problems such as red capillary, vulnerable to
To stimulation, easily general red etc. can be addressed.
Test method: skin of living body tissue, the embodiment 1-5 of test group concentration 2%, comparative example 1~7 are handled,
Control group is not processed.Culture surveyed its epidermal thickness after 72 hours.Test result is shown in Table 5, Fig. 1~2.
Table 5 promotes epidermal thickness to increase test result
| Processing method | Epidermal thickness (um) |
| Blank control | 83 |
| Embodiment 1 | 93 |
| Embodiment 2 | 94 |
| Embodiment 3 | 92 |
| Embodiment 4 | 98 |
| Embodiment 5 | 95 |
| Comparative example 1 | 87 |
| Comparative example 2 | 85 |
| Comparative example 3 | 88 |
| Comparative example 4 | 89 |
| Comparative example 5 | 85 |
| Comparative example 6 | 86 |
| Comparative example 7 | 89 |
The result shows that the skin repair composition in the present invention can effectively increase epidermal thickness, and Examples 1 to 5
It is substantially better than comparative example 1~7.
4, extracorporeal anti-inflammatory effect test is studied
Test method: by HaCat cell by being inoculated in 12 orifice plates, cultivating 18- in the incubator after culture medium culture
24h；Culture plate is taken out, original fluid in hole is discarded, it is 2% that embodiment 1-5, comparative example 1~7, which are diluted to concentration with culture solution,
It is separately added into hole after concentration, each 1mL, LPS (bacteria lipopolysaccharide) is added and is used as stimulant；LPS and training is only added in control group
Nutrient solution, culture is for 24 hours.Stoste is removed, 1mL fresh medium is added, continues culture for 24 hours.Result detection is carried out with kit.As a result
It is shown in Table 6.
6 extracorporeal anti-inflammatory test result of table
The result shows that the present invention in skin repair composition for TNF-α, PGE 2, tetra- kinds of inflammation of IL-6, IL-8 because
The generation of son has good inhibitory effect, and 1~5 inhibitory effect of the embodiment of the present invention is substantially better than comparative example 1~7.
5, promote the experimental study of epidermal renewal speed effect
Damaged skin is not caught up with the demand of skin, cannot be formed complete skin due to its damage, the renewal speed of skin
Barrier, and then more skin problems are generated, form vicious circle.When the renewal speed of skin can satisfy the demand of skin,
Skin is capable of forming complete barrier, obstructs damage of the external substance to skin, further skin is helped to be repaired.
Test method: selecting the age between 25-35 years old, and healthy volunteer 10.Its skin of back is carried out using DHA
Processing, makes the artificial blackening of skin.The embodiment 1-5 of test group concentration 2%, comparative example 1~7 are handled, negative control group
It is not processed, positive controls are handled using Glycolic acid.It the 0th day after the test, 1 day, 4 days, 7 days, 10 days, measures within 14 days
The skin color of volunteer judges its skin renewal speed by the variation of skin color, when skin color restores to original face
When color, it is considered as epidermal skin and updates completion.Test result is shown in Table 7.
The test result of the promotion epidermal renewal speed effect of table 7
The result shows that it is better than comparative example 1~7 using the epidermal renewal speed of the volunteer of embodiment 1-5, it can be with Glycolic acid
It compares favourably, 4-5 days faster than the renewal speed of normal skin using the epidermal renewal speed of the volunteer of embodiment 1-5, thus says
Bright skin repair composition of the present invention can effectively promote epidermal renewal.
Three, experimental study of the skin repair composition of the present invention in cosmetics
1, the preparation of cosmetics
8 emulsion formulations of table
(1) 1-4 raw material in formula is added in main cooker, is heated to 70-85 DEG C, homogenous disperse is uniform, heat preservation
30min obtains A phase；
(2) 5-9 raw material in formula is added in oil cauldron, is heated to 70-85 DEG C, be dispersed with stirring uniformly heat preservation
30min obtains B phase；
(3) B is added in A phase, then homogeneous 8-12min starts to cool down, is cooled to 50-60 DEG C, No. 10 originals are added
Material, stirs evenly；Continue to be cooled to 40-45 DEG C, remaining No. 11 raw materials are added, is uniformly mixed, continues to be cooled to 38 DEG C
With bottom discharge, the cosmetic emulsion containing skin repair composition of the present invention is obtained.
2, for the skin barrier repairing effect experimental study of sensitive skin
2.1 test philosophy
Percutaneous moisture loss rate (TEWL) is to measure the variation of skin surface moisture vapor pressure, is to be able to reflect skin barrier
The index of the quality of function.When the barrier function of skin is damaged, then TEWL value increases, conversely, working as skin barrier function
When reparation, then TEWL value reduces.The unit of TEWL is g/m2h, test equipment Vapometer.In clinical trial, pass through survey
Surely the variation of the barrier function of skin can be directly reacted using the variation of the TEWL value of the skin before and after product, so that reflection is produced
Repair of the product for sensitive flesh.
2.2 test method
The age is selected between 25-50 years old, face is sensitive, there is the volunteer of apparent general red, itch, the symptom of drying
100, it is divided into 5 groups, every group of 20 people keep every group of mean skin situation close as far as possible, test the initial TEWL of skin of face；Even
Continue and tests TEWL after using samples of latex A~E 14 days.Test result is as follows, wherein △ TEWL=TEWL (D14)-TEWL
(D0).Volunteer is allowed to carry out self-assessment by questionnaire to skin (general red, itch) simultaneously.
2.3 test results, are shown in Table 9~11.
9 skin barrier repairing test result of table
The result shows that using five groups of volunteers of embodiment 1-5 lotion average percutaneous moisture loss value under
Drop, i.e., skin barrier function is repaired.Illustrate that the skin repair composition in the present invention can effectively repair skin barrier.
10 volunteer of table is to general red self-assessment result
The result shows that being improved using the heat flush symptom of five groups of volunteers of embodiment 1-5 lotion, slightly improve
And the percentage being obviously improved can averagely arrive the skin repair composition illustrated in the present invention to 80% or more and change to general red symptom
It is kind that there is certain effect.
Self-assessment result of 11 volunteer of table to itch
The result shows that being greatly improved using the skin itching symptom of five groups of volunteers of embodiment 1-5 lotion, hence it is evident that
Improve and improve great percentage averagely and can arrive the skin repair composition illustrated in the present invention to 80% or more have it is obvious
Effect.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of skin repair composition, which is characterized in that by weight, raw material components include:
Cer NP, 1-10 parts by weight；
Hydrolecithin, 5-15 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 5-15 parts by weight；
Strigose oat extract, 5-15 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10-20 parts by weight；
Gotu Kola P.E, 5-15 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.5-2 parts by weight.
2. skin repair composition according to claim 1, which is characterized in that by weight, raw material components include:
Cer NP, 3-7 parts by weight；
Hydrolecithin, 8-12 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 8-12 parts by weight；
Strigose oat extract, 8-12 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10-15 parts by weight；
Gotu Kola P.E, 8-12 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 0.8-1.5 parts by weight.
3. skin repair composition according to claim 1, which is characterized in that by weight, raw material components include:
Cer NP, 5 parts by weight；
Hydrolecithin, 10 parts by weight；
Hydrogenated olive oil unsaponifiable matter, 10 parts by weight；
Strigose oat extract, 10 parts by weight；
Tetrahydro methylpyrimidine carboxylic acid, 10 parts by weight；
Gotu Kola P.E, 10 parts by weight；
Hydroxyethyl piperazine ethane sulfonic acid, 1 parts by weight.
4. the preparation method of any one of the claim 1-3 skin repair composition, which comprises the steps of:
(1) Cer NP, hydrolecithin, hydrogenated olive oil unsaponifiable matter are mixed, heats while stirring, then cool down, obtains
To component A；
(2) Xiang Shuizhong sequentially adds strigose oat extract, tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, ethoxy piperazine
Piperazine ethane sulfonic acid is stirred to dissolve completely, obtains component B；
(3) component A is added in Xiang Zufen B, stirs evenly to get the skin repair composition.
5. the preparation method according to claim 4, which is characterized in that in step (1), the speed of the stirring is 20-
100r/min, the temperature that is heated to is 85-90 DEG C, described to be cooled to 45 DEG C or less.
6. the preparation method according to claim 4, which is characterized in that in step (2), the strigose oat extract,
Tetrahydro methylpyrimidine carboxylic acid, Gotu Kola P.E, the gross mass of four kinds of raw materials of hydroxyethyl piperazine ethane sulfonic acid and water quality it
Than for 1:0.5-1.7.
7. preparation method according to claim 6, which is characterized in that the strigose oat extract, tetrahydro methyl are phonetic
Pyridine carboxylic acid, Gotu Kola P.E, the gross mass of four kinds of raw materials of hydroxyethyl piperazine ethane sulfonic acid and water mass ratio be 1:1.3.
8. the preparation method according to claim 4, which is characterized in that in step (3), the speed of the stirring is 20-
100r/min, the time of the stirring are 10-15min.
9. a kind of cosmetics including any one of the claim 1-3 skin repair composition, which is characterized in that the skin
Additive amount of the remediation composition in cosmetics is 2-5wt%.
10. application of any one of the claim 1-3 skin repair composition in cosmetics.
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| CN110478264A (en) * | 2019-09-29 | 2019-11-22 | 上海克琴科技有限公司 | A kind of cosmetic or skin composition with delay skin aging effect |
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| CN114886807A (en) * | 2022-04-29 | 2022-08-12 | 美出莱(杭州)化妆品有限责任公司 | Composition with omnibearing skin barrier repair function and preparation method and application thereof |
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