CN111494264A - Active composition for repairing ultraviolet injury, preparation method and application thereof - Google Patents
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses an active composition for repairing ultraviolet injury, a preparation method and application thereof, wherein the active composition for repairing ultraviolet injury comprises raw material components of tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, saffron extract, β -glucan and water.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an active composition for repairing ultraviolet injury, and a preparation method and application thereof.
Background
Ultraviolet rays are the most important external factor causing skin aging, the ultraviolet rays can directly damage DNA, and the DNA has a plurality of absorption peaks near 260nm, so the DNA can absorb the ultraviolet rays to perform chemical reaction. UVA emitted from the sun is 10 times higher than UVB, which can penetrate the epidermis to the dermis, causing greater damage to the skin. Ultraviolet damage is the accumulation of damage from improper protection when exposed to ultraviolet light for extended periods of time. The external manifestations of uv damage are elevated skin temperature, formation of dandruff, itching, erythema, pigmentation, wrinkles, etc.; the intrinsic manifestations are sunburn cell formation, cellular DNA damage, increased free radical content, etc. The skin is stimulated by ultraviolet rays, and the skin aging is accelerated, and the process can be avoided and repaired. With the improvement of the consumption level of people, the outdoor activity frequency is gradually improved, the probability of the skin being damaged by ultraviolet rays is greatly increased, and the efficacy cosmetic for repairing the ultraviolet ray damage becomes an indispensable product for consumers.
At present, a plurality of products for repairing ultraviolet injury exist in the market, and mainly relate to after-sun repair products. The after-sun repair product is designed mainly aiming at the external manifestations of skin surface temperature rise, erythema, pigmentation, wrinkles and the like after ultraviolet injury, and generally mainly has the effects of physical cooling, soothing and calming and brightening skin color. The skin care product is used in different steps, firstly spray or facial mask is used for cooling the surface of the skin, then the soothing and calming product is used for soothing the skin and relieving inflammation, and finally the product containing the whitening component is used for brightening the skin color. The existing after-sun repair products cannot improve the immunity of cells to ultraviolet rays, and repair free radicals, cell DNA damage and the like caused by ultraviolet rays from deeper layers. Therefore, the problems of erythema, dull skin color, wrinkles and the like caused by ultraviolet ray damage cannot be fundamentally solved.
Disclosure of Invention
The invention aims to provide an active composition for repairing ultraviolet injury, which is added into a skin care product and can effectively reduce the formation of sunburn cells, inhibit the damage of ultraviolet rays to cell DNA and inhibit the increase of free radical content so as to improve the immunocompetence of cells to ultraviolet rays. The invention provides a solution for repairing ultraviolet injury from inside to outside, and the solution has better ultraviolet injury repairing effect compared with the traditional after-sun repairing product.
The technical scheme of the invention is as follows:
an active composition for repairing ultraviolet injury comprises Tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, stigma croci Sativi extract, β -dextran, and water.
The tremella polysaccharide is derived from tremella sporophore, is a kind of biogenic hyaluronic acid, and is water soluble high molecular heteropolysaccharide extracted from tremella, and has moisturizing performance superior to hyaluronic acid, excellent film forming property and smooth feeling. It has effects in enhancing cellular immunity, scavenging free radicals, resisting aging, enhancing skin moisture, and reducing skin texture.
The glycogen is prepared by taking waxy corn starch as a raw material through an enzymatic synthesis method. Can improve the ability of cell to resist ultraviolet, inhibit apoptosis caused by ultraviolet, and inhibit erythema generated by UVB irradiation; it can be used for improving wrinkle.
Hydroxyethylpiperazine ethanesulfonic acid is a very effective biological buffer, maintaining the structure and active components of biological enzymes. Can absorb UVA, has synergistic anti-photoaging effect, promotes cutin regeneration, and reduces wrinkle.
The saffron extract is a soothing anti-inflammatory active ingredient and is extracted from saffron planted in native organic agriculture of France. The saffron extract can be used for remarkably solving the discomfort of skin stabbing pain, red swelling and burning caused by ultraviolet rays, controlling skin micro-inflammation and repairing the skin damaged by ultraviolet irradiation.
β the glucan is obtained by fermenting Saccharomyces cerevisiae, and is polysaccharide composed of glucose connected by glycosidic bond, and has effects in keeping moisture, relieving stress, and promoting cell synthesis of collagen.
The inventor is dedicated to the development of after-sun repair products for a long time, and in the process of carrying out a large number of experiments and repeated exploration, the inventor discovers that the effect of compounding the 5 active substances is remarkable in the aspects of lightening the sunburn of sensitive skin and lightening erythema, and further discovers that the combination shows remarkable effects in the tests of free radical clearance rate, improving the immunity of Langerhans cells to ultraviolet rays, reducing the formation of sunburn cells and repairing the DNA damage of cells caused by ultraviolet rays through deeper research, so that the invention fully shows that the composition can repair the external problems of the skin caused by the ultraviolet rays from deeper layers, and provides a new solution for the current situation that the existing after-sun repair products are difficult to further develop in the aspect of effect.
Preferably, the raw material components comprise, by weight, 5-10 parts of tremella polysaccharide, 20-25 parts of glycogen, 5-7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5-8 parts of β -glucan and 50 parts of water.
Preferably, the raw material components comprise, by weight, 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -glucan and 50 parts of water.
Preferably, the raw material components comprise, by weight, 10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -glucan and 50 parts of water.
Preferably, the raw material components comprise, by weight, 8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -glucan and 50 parts of water.
Preferably, the raw material components comprise, by weight, 8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -glucan and 50 parts of water.
Preferably, the raw material components comprise, by weight, 5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 8 parts of β -glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury comprises the following specific steps: respectively weighing the raw materials, and stirring to dissolve uniformly.
The active composition for repairing ultraviolet injury has multiple purposes, is easy to add into essence, emulsion or cream to provide multiple effects of repairing after sun, resisting wrinkles, brightening and the like, for example, the active composition is added into the essence for repairing after sun, and the adding amount is generally 1.5-2.5 wt%.
The invention has the beneficial effects that:
the active composition for repairing ultraviolet injury has an obvious effect of repairing ultraviolet injury, and in-vitro test results show that the active composition for repairing ultraviolet injury can effectively reduce free radicals caused by ultraviolet rays, improve the immunity of Langerhans cells to ultraviolet rays, reduce the formation of sunburn cells caused by ultraviolet irradiation, and repair cell DNA injury caused by ultraviolet rays. Human body test results show that the essence added with the ultraviolet injury repairing active composition can effectively reduce erythema caused by ultraviolet irradiation, effectively improve skin brightness and reduce wrinkle depth. The composition is mild, safe and non-irritant, has a simple preparation method, and is easy to add into various skin care products to provide multiple functions of after-sun repair, wrinkle resistance, brightening and the like.
Drawings
FIG. 1: reducing experimental results of sunburn cell formation;
FIG. 2: repairing cell DNA damage caused by ultraviolet rays;
FIG. 3: and (5) testing the erythema value under ultraviolet irradiation.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTER Technopole), 5 parts of β -glucan (Active concentrates) and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury, which is provided by the embodiment, comprises the steps of weighing the raw materials in parts by weight respectively, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, a saffron extract and β -glucan at normal temperature, and stirring to dissolve uniformly to obtain the active composition.
Example 2
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 5 parts of β -glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury, which is provided by the embodiment, comprises the steps of weighing the raw materials in parts by weight respectively, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, a saffron extract and β -glucan at normal temperature, and stirring to dissolve uniformly to obtain the active composition.
Example 3
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 5 parts of β -glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury, which is provided by the embodiment, comprises the steps of weighing the raw materials in parts by weight respectively, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, a saffron extract and β -glucan at normal temperature, and stirring to dissolve uniformly to obtain the active composition.
Example 4
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 5 parts of β -glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury, which is provided by the embodiment, comprises the steps of weighing the raw materials in parts by weight respectively, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, a saffron extract and β -glucan at normal temperature, and stirring to dissolve uniformly to obtain the active composition.
Example 5
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 8 parts of β -glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury, which is provided by the embodiment, comprises the steps of weighing the raw materials in parts by weight respectively, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, a saffron extract and β -glucan at normal temperature, and stirring to dissolve uniformly to obtain the active composition.
Comparative example
The difference between the comparative example and the example 1 is only that the cactus stem extract with the relieving and repairing function is used for replacing saffron crocus extract, and concretely, the comparative example comprises the following raw materials, by weight, 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of the cactus stem extract, 5 parts of β -glucan and 50 parts of water.
The essence is prepared by respectively using the active compositions for repairing ultraviolet injury prepared in the above examples 1-5 and comparative examples, and the formula of the essence is as follows:
TABLE 1 essence formula
The preparation method comprises the following steps: adding water, methyl propylene glycol, glycerol and xanthan gum into a main pot, heating to 85 deg.C, homogenizing, dispersing, and keeping the temperature for 30 min; cooling, adding the rest raw materials at 45 deg.C, stirring and mixing; cooling to 38 deg.C and discharging.
Firstly, safety test
Skin patch test 50 persons, all meeting the subject standards, the active composition for repairing ultraviolet injury of examples 1 to 5, comparative example, and a commercially available sample (after-sun repair essence) were placed in a patch tester cell at an amount of about 0.020m L to 0.025m L, the control hole was blank (no substance was placed), the patch tester with the subject added was applied to the back or forearm curl side of the subject with a hypoallergenic tape, gently pressed with the palm to be uniformly applied to the skin for 24 hours, skin reactions were observed according to the following table standards 30min after the patch tester was removed (after the impression disappeared), 24 hours, and 48 hours, respectively, and the observation results were recorded.
TABLE 2 skin closure Patch test skin response grading Standard
TABLE 3 test results of human skin patches
As can be seen from the test results, the active composition for repairing ultraviolet injury of the invention does not cause skin allergy, and has higher skin use safety compared with the commercial products.
Second, efficacy test
1. In vitro testing
1.1 free radical scavenging test
The test method comprises the following steps: adopts an Organotypical skin model
Skin models were pretreated with a 1:10 dilution containing 2% of the inventive example and comparative UV-damage-repairing active composition solution, commercial samples and placebo, respectively, with pbs buffer, and subjected to different intensity UV irradiation (0-30 mJ/cm)2UVB intensity), the test results are as follows:
table 4 free radical scavenging test results
As can be seen from the above test results, the UV damage repairing active composition of the present invention can effectively reduce free radicals caused by UV.
1.2 test for enhancing the immunological competence of Langerhans cells to ultraviolet light
The test method comprises the following steps: in vivo; the medial aspect of the forearm was treated with the samples of examples 1-5, comparative examples (1.5%, 2.0%, 2.5%) and the commercial sample for 2 weeks (4 cm)2) Comparison to placebo; UV-exposure (1.5 MED); langerhans cells were tested by ATPase histological staining sections; the test results were as follows:
TABLE 5 test results for increasing the immunity of Langerhans cells to UV light
From the test results, the composition for repairing ultraviolet injury of the invention can effectively improve the immunity of the Langerhans cells to ultraviolet rays, and the effect is obviously stronger than that of a comparative example and a commercial product.
1.3 experiment for reducing formation of sunburn cells
The test method comprises the following steps:
the skin model was pretreated with a 1:10 dilution containing the solutions of examples and comparative examples (2%) with pbs buffer, respectively; 100mJ/cm2Ultraviolet irradiation at UVB intensity; the number of sunburn cells was observed with a microscope. The test results are shown in FIG. 1. As can be seen from the test results, the UV damage repairing active composition of the present invention can effectively reduce the formation of sunburn cells caused by UV irradiation, and the effect is superior to that of the comparative example and the commercially available samples.
1.4 repair of UV-induced cellular DNA damage
The test method comprises the following steps: in vitro; in vitro analysis; examples 1-5, comparative (2%) solution, commercial sample and placebo were pre-incubated with pbs buffer 1:10 for 24h, 5J/cm for HaCaT-keratinocyte cells2UVA irradiation, DNA damage due to UVA was assessed. The test results are shown in FIG. 2. As can be seen from the above test results, the UV damage repairing active composition of the present invention can effectively repair UV-induced cellular DNA damage, and is superior to comparative examples and commercially available samples.
2. Trial by the consumer
2.1 erythema value test under UV irradiation
Randomly selecting 27 healthy volunteers, and respectively administering 1-6# essence, a commercially available sample and a placebo; the method comprises the following steps: 2 times a day (1 in the morning and evening), 2 hours post-application UVB irradiation for one month, and erythema values were measured using a Mexameter skin melanin and heme tester. The test results are shown in FIG. 3. From the test results, it can be seen that the essence added with the ultraviolet injury repairing active composition of the embodiment of the invention can effectively reduce erythema caused by ultraviolet irradiation, and the effect is better than that of the comparative example composition sample and the commercial sample.
2.2 skin gloss measurement
The test method comprises the following steps: the skin gloss tester glossimeter, the larger the value, the better the skin gloss.
20 parts of the No. 1-6 essence and a commercially available sample are respectively used by female consumers, the female consumers are aged 25-60 years, 2 times in 1 day (1 time in the morning and evening), after the application of the essence, the UVB is irradiated for 2 hours, and the gloss of the cheek parts is tested after the continuously used sample is continuously used for 1 month for one month. The test results were as follows:
table 6 skin gloss test results
From the test results, the essence added with the ultraviolet injury repairing active composition of the embodiment of the invention can effectively improve the skin brightness, and the effect is better than that of the sample added with the comparative example and the commercially available sample.
2.3 wrinkle depth reduction test
The test method comprises the following steps: the smaller the value of the wrinkle parameter SEw, the fewer wrinkles in the skin texture and active skin surface analysis system VC20 plus; the No. 1-6 essence and the commercial samples account for 20 parts in total, and are used for wrinkle removal tests for 1 day and 2 times by consumers for 1 month continuously. The test results were as follows:
table 7 wrinkle depth reduction test results
From the test results, the essence added with the ultraviolet injury repairing active composition provided by the embodiment of the invention can effectively reduce the wrinkle depth, and the effect is better than that of the essence added with the comparative example and a commercially available sample.
In summary, it can be seen from the experimental results that: 1. the active composition for repairing ultraviolet injury can effectively reduce free radicals caused by ultraviolet rays, improve the immunocompetence of Langerhans cells to the ultraviolet rays, reduce the formation of sunburn cells caused by ultraviolet irradiation, repair the DNA damage of the cells caused by the ultraviolet rays, and further solve the problem of ultraviolet injury from a deeper surface; 2. in addition, the effect is obviously weakened after the saffron extract in the composition is replaced by the twisted cactus stem extract, which shows that the effect of repairing ultraviolet injury is related to the specific raw material composition of the invention, and the composition has obvious superiority compared with the prior art.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. An active composition for repairing ultraviolet injury is characterized by comprising tremella polysaccharide, glycogen, hydroxyethyl piperazine ethanesulfonic acid, saffron extract, β -glucan and water.
2. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw material components comprise, by weight, 5-10 parts of tremella polysaccharide, 20-25 parts of glycogen, 5-7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5-8 parts of β -dextran, and 50 parts of water.
3. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw material components comprise, by weight, 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -dextran, and 50 parts of water.
4. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw materials comprise, by weight, 10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -dextran, and 50 parts of water.
5. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw material components comprise, by weight, 8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -dextran, and 50 parts of water.
6. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw material components comprise, by weight, 8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 5 parts of β -glucan, and 50 parts of water.
7. The active composition for repairing ultraviolet injury according to claim 1, wherein the raw material components comprise, by weight, 5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethanesulfonic acid, 10 parts of saffron extract, 8 parts of β -glucan, and 50 parts of water.
8. The preparation method of the active composition for repairing ultraviolet injury of any one of claims 1-7 is characterized by comprising the following steps: respectively weighing the raw materials, and stirring to dissolve uniformly.
9. Use of the UV damage repairing active composition according to any one of claims 1-7 in a serum, lotion or cream with sunscreen repair function.
10. The use according to claim 9, wherein the UV damage repairing active composition is added in an amount of 1.5-2.5 wt%.
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|---|---|---|---|---|
| CN114081853A (en) * | 2021-03-26 | 2022-02-25 | 太和康美(北京)中医研究院有限公司 | Plant composition and preparation method and application thereof |
| CN114081853B (en) * | 2021-03-26 | 2023-08-04 | 太和康美(北京)中医研究院有限公司 | Plant composition and preparation method and application thereof |
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