CN112891243A - Cosmetic containing anti-wrinkle composition and preparation method thereof - Google Patents

Abstract

A cosmetic containing anti-wrinkle composition and its preparation method belong to the technical field of cosmetics, and comprise ginsenoside, cornu Cervi Pantotrichum peptide, resveratrol, hydrolyzed collagen, sodium hyaluronate, superoxide dismutase and Mel. The invention is prepared from pure natural materials, and has better protection effect on oxidative damage of human immortalized keratinocyte and human dermal fibroblast caused by ultraviolet radiation. The cell growth can be promoted, the secretion levels of matrix metalloproteinase and malonaldehyde are reduced, the secretion level of glutathione peroxidase is improved, and the anti-wrinkle anti-aging effect is very outstanding; the skin elasticity is well improved through reasonable matching, the skin darkness is improved, the skin vitality is improved, fine lines are relieved, and the skin is full of brightness; and the product has better cold and hot stability, safety and absorption feeling.

Description

Cosmetic containing anti-wrinkle composition and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle composition and application thereof in cosmetics.

Background

In recent years, with the acceleration of industrialization, a large amount of exhaust gas is dischargedIn addition, the ozone layer is destroyed, the thickness of the ozone layer is reduced, so that the ultraviolet radiation reaching the ground is enhanced, and the ultraviolet radiation in sunlight easily causes photoaging damage of the skin, which is one of the most important factors for skin aging. Long-term UVB irradiation can induce skin oxidative stress reaction to form oxygen free radicals and lipid peroxide, so as to weaken differentiation ability and sebum secretion ability of skin tissue, reduce collagen in dermis, reduce water retention ability, reduce skin elasticity, become slack and dry, and further cause wrinkle^[4]Exhibiting an aging phenotype. The free radical in skin cell is eliminated mainly through antioxidation, and the main action mechanism of the free radical elimination is to provide electron directly to reduce free radical and strengthen the activity of antioxidant enzyme, so as to eliminate free radical fast and protect cell against oxidation damage^[5]。

The prior art is to add plant extracts, small molecular compounds and small molecular peptides into the formula of the traditional skin care cosmetics to obtain the cosmetics with the effects of moisturizing the skin and resisting wrinkles. When the cosmetic is applied to the skin surface of a user, the cosmetic promotes the growth of skin cells, maintains the youthful state of the skin, and allows the user to receive the effects of moisturizing and anti-wrinkle^[6]。

Chinese patent application CN108703909A discloses a cream prepared from a composition with anti-wrinkle and anti-aging effects, which comprises deionized water, xanthan gum, sodium cocoyl sarcosinate, erythritol, acetyl chitosamine, sodium lauryl amphoacetate, ascorbyl glucoside, arbutin, butylene glycol, glycerin, glycyrrhiza glabra extract, bacillus coagulans juglans regis pericarpium juglandis fermented extract, pleurotus persicae extract, green tea extract, chamomile extract, glycerol undecylenate and the like. Has certain anti-wrinkle effect, but needs further improvement in water activity and moisture retention.

Chinese patent application CN110897987A discloses a composition for resisting wrinkles and tightening skin and application thereof in cosmetics. The main effective components comprise the following components: glass seed oil, betaine, snail secretion, schizosaccharomyces cerevisiae fermentation product lysate, hypecoum vulgare extract, oligopeptide-1, xanthan gum, tocopherol acetate, fullerene, triethanolamine and the like. Has better effects of resisting wrinkles, tightening, whitening and moisturizing, but needs further improvement in the aspects of nourishing and activating blood and caring skin.

Therefore, there is a need in the art for a new solution to solve the above problems.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: aiming at the defects of single effect, low safety and easy rebound of the anti-wrinkle cosmetics in the prior art, the cosmetics containing the anti-wrinkle effect composition and the preparation method thereof are provided, the problems of skin aging and wrinkle generation are solved, and the water and the skin are revived to keep moisture.

An anti-wrinkle effect composition is characterized in that: comprises ginsenoside, antler peptide, resveratrol, hydrolyzed collagen, sodium hyaluronate, superoxide dismutase and honey.

The composition also comprises a thickening agent, a humectant, a surfactant, an emollient, a cosurfactant, a preservative, a pH regulator, an essence and deionized water.

The composition comprises, by mass, 0.1-1% of ginsenoside, 0.5-2% of antler peptide, 0.1-1% of resveratrol, 0.5-2% of hydrolyzed collagen, 0.1-1% of sodium hyaluronate, 0.5-2% of superoxide dismutase, 0.5-2% of honey, 0.4-2% of thickening agent, 10-20% of humectant, 2-10% of emollient, 10-25% of surfactant, 2-8% of cosurfactant, 0.1-0.5% of preservative, 0.2-0.6% of pH value regulator, 0.01-0.02% of essence and 60-80% of deionized water.

The thickener is a mixture of xanthan gum and carbomer.

The emollient is one of liquid paraffin, polydimethylsiloxane or polymethylphenylsiloxane.

The surfactant is any one or more of stearate, glyceryl monostearate, cetearyl alcohol or polyoxyethylene hydrogenated castor oil;

the humectant is any one or more of propylene glycol, glycerin or sodium hyaluronate;

the cosurfactant is polyethylene glycol 400, isopropanol or a combination of the two.

The preservative is any one or mixture of phenoxyethanol and methylparaben; the pH value regulator is triethanolamine; the hydrolyzed collagen is cod hydrolyzed collagen.

A skin care product containing an anti-wrinkle effect composition is characterized in that: 1-20% of the anti-wrinkle composition comprises a gel mask and a cream.

A preparation method of a skin care product containing a composition with an anti-wrinkle effect is characterized by comprising the following steps: the preparation of the gel mask comprises the following steps which are sequentially carried out,

step one, adding a humectant, a preservative and a thickening agent into deionized water, adding sodium hyaluronate, stirring to fully soak the mixture, standing for 12-15 hours at room temperature to fully swell and uniformly disperse the mixture to obtain a phase A;

step two, heating resveratrol, a surfactant, a cosurfactant and deionized water at 37 ℃ until the resveratrol, the surfactant, the cosurfactant and the deionized water are completely dissolved, and uniformly stirring to obtain a phase B;

and step three, adding the phase B into the phase A, stirring, simultaneously dripping a triethanolamine solution to adjust the pH value to 5.5-7, adding ginsenoside, antler peptide, hydrolyzed collagen, superoxide dismutase and honey, homogenizing, stirring, centrifuging to remove bubbles, and standing to obtain the gel mask.

A preparation method of a skin care product containing a composition with an anti-wrinkle effect is characterized by comprising the following steps: the preparation of the face cream comprises the following steps which are carried out in sequence,

step one, adding a humectant, a preservative and a thickening agent into deionized water, adding sodium hyaluronate, heating at 85 ℃ and stirring to obtain a phase A;

step two, mixing the surfactant and the emollient, heating and stirring at 85 ℃ until the surfactant and the emollient are completely dissolved, adding the pH value regulator, and uniformly stirring to obtain a phase B;

step three, heating resveratrol, a surfactant, a cosurfactant and deionized water at 37 ℃ until the resveratrol, the surfactant, the cosurfactant and the deionized water are completely dissolved, and uniformly stirring to obtain a phase C;

and step four, when the temperature is reduced to 75 ℃, adding the phase B into the phase A for homogenizing and stirring, then adding the phase C, when the temperature is reduced to 45 ℃, adding the ginsenoside, the antler peptide, the hydrolyzed collagen, the superoxide dismutase and the honey, homogenizing and stirring, discharging, and standing to obtain the cream.

Through the design scheme, the invention can bring the following beneficial effects: a cosmetic containing anti-wrinkle composition and its preparation method, is prepared from pure natural materials, has good effects of improving skin elasticity through rational collocation, improve skin darkness, improve skin vigor, relieve fine lines while also making skin full of gloss; and the product has better cold and hot stability, safety and absorption feeling.

Furthermore, the cosmetic prepared by the invention has the effects of moisturizing, whitening, nourishing and moistening skin and the like besides the anti-wrinkle effect, and the anti-wrinkle effect composition is easy to absorb and can replace various skin care products with single effect after being used;

the cosmetic has stable dosage form, simple and reliable process and controllable quality, and compared with an external solution, the cosmetic can prolong the retention time of the medicine on the skin surface and increase the bioavailability of the medicine;

the ginsenoside, the antler peptide, the cod hydrolyzed collagen and the resveratrol have good synergistic effect, can effectively remove skin wrinkles, promote the formation and metabolism of skin, stimulate the production of new skin cells and ensure that the skin is tender and glossy;

the sodium hyaluronate and the honey can effectively regulate skin moisture, so that the skin moisture is activated and moisturized, nourishes and activates blood, moisturizes skin and promotes tissue regeneration, and has high elasticity;

the superoxide dismutase disclosed by the invention has the effects of removing free radicals, improving the skin activity and relieving fine wrinkles;

the anti-wrinkle effect composition has a good protection effect on oxidative damage of human immortalized keratinocytes (HaCaT) and human dermal fibroblasts (HDF-alpha) caused by ultraviolet radiation. Can promote cell growth, reduce secretion levels of matrix metalloproteinase (MMP-9) and Malondialdehyde (MDA), improve secretion level of glutathione peroxidase (GSH-Px), and has remarkable anti-wrinkle and anti-aging effects.

Drawings

The invention is further described with reference to the following figures and detailed description:

fig. 1 is a schematic diagram of the effect of different concentrations of the anti-wrinkle effect composition on cell proliferation.

FIG. 2 is a graph showing the effect of the anti-wrinkle composition according to the present invention on the level of cell-secreted metalloprotease (MMP-9) at various concentrations.

Fig. 3 is a schematic diagram of different concentrations of the anti-wrinkle effect composition according to the present invention versus the level of Malondialdehyde (MDA) secreted by cells.

FIG. 4 is a graph showing the different concentrations of the anti-wrinkle effect composition according to the present invention versus the levels of glutathione peroxidase (GSH-Px) secreted by cells.

Detailed Description

A method for preparing a cosmetic composition with anti-wrinkle effect comprises the following steps,

example 1 preparation of gel mask containing anti-wrinkle composition

Preparing raw materials, namely preparing raw materials,

phase A: 50% of deionized water, 10% of glycerol, 5% of propylene glycol, 0.4% of phenoxyethanol, 0.2% of xanthan gum and 0.2% of sodium hyaluronate;

phase B: 0.8% of carbomer;

and C phase: 0.2% of resveratrol, 1% of glyceryl triacetate, 1% of polyoxyethylene hydrogenated castor oil, 4002% of polyethylene glycol and 23% of deionized water;

phase D: 0.6 percent of triethanolamine;

phase E: ginsenoside 0.5%, antler peptide 0.5%, hydrolyzed collagen 0.5%, superoxide dismutase 0.5%, honey 1%, and deionized water 3%;

and (3) phase F: 0.01 percent of essence.

The preparation process comprises the following steps of (1),

adding the phase A into water, fully stirring to dissolve the phase A, slowly adding the phase B to fully soak the phase A, and standing at room temperature for 12-15 hours to fully swell and uniformly disperse the phase A;

step two, heating the phase C in a water bath at 37 ℃ until the phase C is completely dissolved, and uniformly stirring;

step three, adding the obtained substance in the step two into the obtained substance in the step one, stirring, adding the phase D to adjust the pH value to 5.5-7, and then adding the phase E and the phase F, and homogenizing and stirring; removing air bubbles, and standing to obtain the gel mask.

Example 2 preparation of gel mask containing anti-wrinkle composition

Preparing raw materials, namely preparing raw materials,

phase A: 45% of deionized water, 8% of glycerol, 5% of propylene glycol, 0.2% of phenoxyethanol, 0.3% of xanthan gum and 0.5% of sodium hyaluronate;

phase B: 0.6% of carbomer;

and C phase: 0.4% of resveratrol, 1.5% of glyceryl triacetate, 1.5% of polyoxyethylene hydrogenated castor oil, 4003% of polyethylene glycol and 24% of deionized water;

phase D: 0.5 percent of triethanolamine;

phase E: 1% of ginsenoside, 1% of antler peptide, 1% of hydrolyzed collagen, 1% of superoxide dismutase, 1.5% of honey and 4% of deionized water;

and (3) phase F: 0.015 percent of essence.

The preparation process comprises the following steps of (1),

adding the phase A into water, fully stirring to dissolve the phase A, slowly adding the phase B to fully soak the phase A, and standing at room temperature for 12-15 hours to fully swell and uniformly disperse the phase A;

step two, heating the phase C in a water bath at 37 ℃ until the phase C is completely dissolved, and uniformly stirring;

step three, adding the step two into the step one, stirring, adding the phase D, adjusting the pH value to 5.5-7, adding the phase E and the phase F, homogenizing and stirring; removing air bubbles, and standing to obtain the gel mask.

Example 3 preparation of a cream containing an anti-wrinkle composition

Preparing raw materials, namely preparing raw materials,

phase A: 55% of deionized water, 6% of glycerol, 3% of propylene glycol, 0.4% of phenoxyethanol, 0.1% of xanthan gum and 0.2% of sodium hyaluronate;

phase B: 4% of stearic acid, 3% of glyceryl monostearate, 1% of octadecanol, 0.5% of triethanolamine, 1% of liquid paraffin and 1% of polydimethylsiloxane;

and C phase: 0.2% of resveratrol, 1% of glyceryl triacetate, 1% of polyoxyethylene hydrogenated castor oil, 4002% of polyethylene glycol and 15% of deionized water;

phase D: ginsenoside 0.5%, antler peptide 0.5%, hydrolyzed collagen 0.5%, superoxide dismutase 0.5%, honey 1%, and deionized water 3%;

phase E: 0.01 percent of essence.

The preparation process comprises the following steps of (1),

step one, adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes, heating to 85 ℃, and stirring until the phase A is completely dissolved.

Step two, adding the phase B into an oil phase pot, stirring and heating to 85 ℃, and stirring until the phase B is completely dissolved;

step three, when the A, B phases reach the specified temperature, adding the phase B into the phase A, stirring for 5 minutes, homogenizing for 15 minutes, preserving the heat for 15 minutes, adding the phase C, stirring and cooling;

and step four, cooling to below 45 ℃, sequentially adding D, E phases, uniformly stirring, and eliminating bubbles to obtain the firming anti-wrinkle emulsion.

Example 4 preparation of a cream containing an anti-wrinkle composition

Preparing raw materials, namely preparing raw materials,

phase A: 40% of deionized water, 8% of glycerol, 5% of propylene glycol, 0.2% of phenoxyethanol, 0.5% of xanthan gum and 0.5% of sodium hyaluronate;

phase B: 3% of stearic acid, 2.5% of glyceryl monostearate, 2% of octadecanol, 0.3% of triethanolamine, 1.5% of liquid paraffin and 1% of polydimethylsiloxane;

and C phase: 0.4% of resveratrol, 1.5% of glyceryl triacetate, 1.5% of polyoxyethylene hydrogenated castor oil, 4003% of polyethylene glycol and 20% of deionized water;

phase D: 1% of ginsenoside, 1% of antler peptide, 1% of hydrolyzed collagen, 1% of superoxide dismutase, 1.5% of honey and 4% of deionized water;

phase E: 0.015 percent of essence.

The preparation process comprises the following steps of (1),

step one, adding the phase A into an emulsifying pot, homogenizing for 3-5 minutes, heating to 85 ℃, and stirring until the phase A is completely dissolved.

Step two, adding the phase B into an oil phase pot, stirring and heating to 85 ℃, and stirring until the phase B is completely dissolved;

step three, when the A, B phases reach the specified temperature, adding the phase B into the phase A, stirring for 5 minutes, homogenizing for 15 minutes, preserving the heat for 15 minutes, adding the phase C, stirring and cooling;

and step four, cooling to below 45 ℃, sequentially adding D, E phases, uniformly stirring, and eliminating bubbles to obtain the anti-wrinkle face cream.

Pharmacodynamic tests verify that the anti-wrinkle effect composition has the influence on the proliferation of immortalized keratinocytes (HaCaT for short in the following and attached figures) and human dermal fibroblasts (HDF-alpha for short in the following and attached figures);

taking cells in exponential growth phase 5X 10⁴Inoculating each/mL suspension into a 96-well culture plate, adding 200 mu L of complete culture medium into each well for culture, placing the culture plate in an incubator at the temperature of 5% CO2 and 37 ℃, culturing for 24h, placing the culture plate under an ultraviolet lamp (UVB) for irradiating for 10min, diluting a liquid medicine prepared from the anti-wrinkle effect composition into a concentration of 6, 12.5, 25, 50, 75, 100, 125, 150 and 200 mu g/mL by an administration group, irradiating the model group and adding DMEM with cell culture, adding DMEM with cell culture into the blank group without irradiation, arranging 5 multiple wells in each group, continuously culturing for 24h after administration, adding 20 mu L of MTT staining solution with the mass concentration of 5g/L into each well, culturing for 4h, then removing supernatant, adding 150 mu L of DMSO, oscillating for 10min, measuring the OD value at the wavelength of 490nm, independently repeating the experiment for 3 times, and calculating the proliferation rate of each group of cells.

Cell proliferation rate (%). 100% for dosing/blank

The composition with anti-wrinkle effect has effects on secretion of matrix metalloproteinase (MMP-9, MDA, and GSH-Px) from HDF-alpha cell and HaCaT cell, and on secretion of glutathione peroxidase (GSH-Px) from cells in exponential growth phase of 5 × 10⁴Each/mL suspension was inoculated into a 96-well plate, and 200. mu.L of complete medium was added to each well and cultured in a 5% CO2, 37 ℃ incubator. After the cells are subjected to drug administration and culture for 24h, supernatant is taken for experiment according to the instruction of the kit, and the supernatant is sequentially reacted with a biotin-labeled antibody, HRP-labeled streptavidin, a chromogenic substrate and stop solution. The blank wells were zeroed and the OD of each well was measured at a wavelength of 450nm within 15min after termination. And calculating a regression equation of the standard curve according to the concentration of the standard substance and the corresponding OD value, and calculating the corresponding secretion amount according to the OD value of the sample, wherein the final concentration is the actual measured concentration multiplied by the dilution factor.

The results of in vitro activity experiments show that in the HaCaT cell aging model, when the drug concentration reaches 50 mug/mL, the proliferation rate of the cells is 89.47% + -1.81% (p < 0.01), in the HDF-alpha cell aging model, when the drug concentration reaches 50 mug/mL, the proliferation rate of the cells is 81.04% + -4.09% (p < 0.01), the results are shown in FIG. 1, compared with the blank group,^**p < 0.01 indicates that the difference is extremely significant,^***p < 0.001 indicates a highly significant difference, compared to the model group,^#p < 0.05 indicates that the difference is significant,^##p < 0.01 indicates that the difference is extremely significant,^###p < 0.001 indicates that the difference is highly significant. The ELISA method is used for detecting the influence of the anti-wrinkle effect composition on MMP-9, MDA and GSH-Px secretion of HDF-alpha cells and HaCaT cells under ultraviolet radiation, the anti-photoaging effect of the composition is investigated when the mass concentration of the composition is 12.5-100 mu g/mL, and the results are shown in figures 2-4,^**p < 0.01 indicates that the difference is extremely significant,^***p < 0.001 indicates a highly significant difference, compared to the model group,^#p < 0.05 indicates that the difference is significant,^##p < 0.01 indicates that the difference is extremely significant,^###p < 0.001 indicates that the difference is highly significant. In a HaCaT cell aging model, when the concentration of the medicine reaches 50 mu g/mL, the content of MMP-9 is 5.46 +/-0.21 ng/mL, the content of MDA is 1.27 +/-0.04 nmol/mL, and the content of GSH-Px is expressed as 41.62 +/-0.40 ng/mL (p is less than 0.01); in the HDF-alpha cell aging model, when the drug concentration reaches 50 mu g/mL, the MMP-9 content is 4.91 +/-0.13 ng/mL, the MDA content is 1.40 +/-0.01 nmol/mL, and the GSH-Px content is expressed as 44.28 +/-0.05 ng/mL (p is less than 0.01). In view of the above, it is desirable to provide,when the concentration of the composition reaches 50 mug/mL, the secretion levels of MMP-9 and MDA after radiation damage can be obviously reduced, the secretion level of GSH-Px is improved, the composition has a good protection effect on light damage of HaCaT cells and HDF-alpha cells, and can be applied to anti-wrinkle cosmetics.

In the process of skin aging, MMP-9, MDA and GSH-Px are important indexes of oxidative damage reaction.

MMP-9 mainly plays a role in degrading the content of collagen and elastin in the skin, and experiments show that the increase of MMP-9 secretion can cause the loss of collagen in the skin, the skin relaxation, the reduction of elasticity and the increase and the deepening of fine wrinkles, so that the skin shows the signs of aging. MDA is one of final products of membrane lipid peroxidation, and the high content and the low content of MDA can be used as one of indexes for examining the severity degree of the stress on cells. MDA can cause macromolecular cross-linking reactions in the tissue, damaging the dermal tissue. GSH-Px is an important enzyme for eliminating hydrogen peroxide and a plurality of organic hydroperoxides in vivo, and toxic hydrogen peroxide and lipid peroxides are reduced into nontoxic hydroxyl compounds by catalyzing glutathione, so that the structure and the function of a cell membrane are protected from being damaged and interfered by peroxides, and the GSH-Px is also one of the indexes of the anti-peroxidation capability of an organism.

The following is a content of the effect verification test example section.

1. Stability test

Test samples: examples 1 to 4 anti-wrinkle gel mask and anti-wrinkle cream

The test method comprises the following steps: centrifuging at 3000r/min for 30min, standing at room temperature, 45 deg.C and-20 deg.C for 24h, and observing whether there is oil-water separation phenomenon in appearance change.

The stability investigation result shows that no oil-water separation phenomenon exists and the appearance is unchanged.

2. Human body trial test

Test samples: examples 4-9 anti-wrinkle gel mask and anti-wrinkle cream

The test method comprises the following steps: folding several layers of gauze into a certain size (5cm × 5cm), sticking the tested object on the gauze, sticking it on the skin, covering a layer of oil paper or plastic film, and fixing with bandage. The test substance was removed after 24h, and the local skin reaction was observed at 0.5h, 24h, and 48h after removal, respectively.

TABLE 1 Patch test results

Remarking: grading standard of skin reaction

Level 0: negative reaction;

level 1: carrying out suspicious reaction; only faint erythema;

and 2, stage: weak positive reaction (erythema reaction); erythema, infiltration, edema, and possibly papules;

and 3, level: strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes, reactions that may be beyond the test area;

4, level: very strong response (fusional herpes response); obvious erythema, severe infiltration, edema, fusional herpes, reaction beyond the test area;

the results in table 1 show no irritation as a safety pass.

Reference documents:

[4] paglijie, a moisturizing, concealer and anti-wrinkle composition and a preparation method thereof [ P ]. Shandong province, CN112137902A,2020-12-29.

[5] A cosmetic composition for anti-wrinkle and its preparing process are disclosed, and its preparing process includes such steps as proportionally mixing raw materials, immersing in water, immersing in alcohol, adding water, stirring, and stirring.

[6] Poplar, Suyingo, Royun, etc. cosmetics with skin moistening and wrinkle resisting functions and their preparation and application [ P ] CN112294683A,2021-02-02.

Claims (10)

1. An anti-wrinkle effect composition is characterized in that: comprises ginsenoside, antler peptide, resveratrol, hydrolyzed collagen, sodium hyaluronate, superoxide dismutase and honey.

2. The anti-wrinkle effect composition according to claim 1, wherein: the composition also comprises a thickening agent, a humectant, a surfactant, an emollient, a cosurfactant, a preservative, a pH regulator, an essence and deionized water.

3. The anti-wrinkle effect composition according to claim 1 or 2, wherein: the composition comprises, by mass, 0.1-1% of ginsenoside, 0.5-2% of antler peptide, 0.1-1% of resveratrol, 0.5-2% of hydrolyzed collagen, 0.1-1% of sodium hyaluronate, 0.5-2% of superoxide dismutase, 0.5-2% of honey, 0.4-2% of thickening agent, 10-20% of humectant, 2-10% of emollient, 10-25% of surfactant, 2-8% of cosurfactant, 0.1-0.5% of preservative, 0.2-0.6% of pH value regulator, 0.01-0.02% of essence and 60-80% of deionized water.

4. The anti-wrinkle effect composition according to claim 2 or 3, wherein: the thickener is a mixture of xanthan gum and carbomer.

5. The anti-wrinkle effect composition according to claim 2 or 3, wherein: the emollient is one of liquid paraffin, polydimethylsiloxane or polymethylphenylsiloxane.

6. The anti-wrinkle effect composition according to claim 2 or 3, wherein: the surfactant is any one or more of stearate, glyceryl monostearate, cetearyl alcohol or polyoxyethylene hydrogenated castor oil;

the humectant is any one or more of propylene glycol, glycerin or sodium hyaluronate;

the cosurfactant is polyethylene glycol 400, isopropanol or a combination of the two.

7. The anti-wrinkle effect composition according to claim 2 or 3, wherein: the preservative is any one or mixture of phenoxyethanol and methylparaben; the pH value regulator is triethanolamine; the hydrolyzed collagen is cod hydrolyzed collagen.

8. A skin care product containing an anti-wrinkle effect composition is characterized in that: 1-20% of an anti-wrinkle composition according to claims 1-7, comprising gel masks and creams.

9. A preparation method of a skin care product containing a composition with an anti-wrinkle effect is characterized by comprising the following steps: preparing the gel mask of claim 8, comprising, and in sequence,

step one, adding a humectant, a preservative and a thickening agent into deionized water, adding sodium hyaluronate, stirring to fully soak the mixture, standing for 12-15 hours at room temperature to fully swell and uniformly disperse the mixture to obtain a phase A;

step two, heating resveratrol, a surfactant, a cosurfactant and deionized water at 37 ℃ until the resveratrol, the surfactant, the cosurfactant and the deionized water are completely dissolved, and uniformly stirring to obtain a phase B;

and step three, adding the phase B into the phase A, stirring, simultaneously dripping a triethanolamine solution to adjust the pH value to 5.5-7, adding ginsenoside, antler peptide, hydrolyzed collagen, superoxide dismutase and honey, homogenizing, stirring, centrifuging to remove bubbles, and standing to obtain the gel mask.

10. A preparation method of a skin care product containing a composition with an anti-wrinkle effect is characterized by comprising the following steps: preparing the cream of claim 8, comprising, and in sequence,

step one, adding a humectant, a preservative and a thickening agent into deionized water, adding sodium hyaluronate, heating at 85 ℃ and stirring to obtain a phase A;

step two, mixing the surfactant and the emollient, heating and stirring at 85 ℃ until the surfactant and the emollient are completely dissolved, adding the pH value regulator, and uniformly stirring to obtain a phase B;

step three, heating resveratrol, a surfactant, a cosurfactant and deionized water at 37 ℃ until the resveratrol, the surfactant, the cosurfactant and the deionized water are completely dissolved, and uniformly stirring to obtain a phase C;

and step four, when the temperature is reduced to 75 ℃, adding the phase B into the phase A for homogenizing and stirring, then adding the phase C, when the temperature is reduced to 45 ℃, adding the ginsenoside, the antler peptide, the hydrolyzed collagen, the superoxide dismutase and the honey, homogenizing and stirring, discharging, and standing to obtain the cream.

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