CN111494264B - Active composition for repairing ultraviolet injury, preparation method and application thereof - Google Patents
Active composition for repairing ultraviolet injury, preparation method and application thereof Download PDFInfo
- Publication number
- CN111494264B CN111494264B CN202010395701.5A CN202010395701A CN111494264B CN 111494264 B CN111494264 B CN 111494264B CN 202010395701 A CN202010395701 A CN 202010395701A CN 111494264 B CN111494264 B CN 111494264B
- Authority
- CN
- China
- Prior art keywords
- parts
- repairing
- active composition
- ultraviolet injury
- glucan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an active composition for repairing ultraviolet injury, a preparation method and application thereof, wherein the active composition for repairing ultraviolet injury comprises the following raw material components: tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, saffron extract, beta-glucan and water. The active composition for repairing ultraviolet injury can effectively reduce the formation of sunburn cells, inhibit the damage of ultraviolet rays to cell DNA and inhibit the increase of free radical content so as to improve the immunocompetence of cells to ultraviolet rays, thereby having obvious effect of repairing ultraviolet injury. The composition is mild, safe and non-irritant, the preparation method is simple, and the composition can be easily added into various skin care products to provide multiple functions of after-sun repair, wrinkle resistance, brightening and the like.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an active composition for repairing ultraviolet injury, and a preparation method and application thereof.
Background
Ultraviolet rays are the most important external factor causing skin aging, the ultraviolet rays can directly damage DNA, and the DNA has a plurality of absorption peaks near 260nm, so the DNA can absorb the ultraviolet rays to perform chemical reaction. UVA emitted from the sun is 10 times higher than UVB, which can penetrate the epidermis to the dermis, causing greater damage to the skin. Ultraviolet damage is the accumulation of damage from improper protection when exposed to ultraviolet light for extended periods of time. The external manifestations of uv damage are elevated skin temperature, formation of dandruff, itching, erythema, pigmentation, wrinkles, etc.; the intrinsic manifestations are sunburn cell formation, cellular DNA damage, increased free radical content, etc. The skin is stimulated by ultraviolet rays, and the skin aging is accelerated, and the process can be avoided and repaired. With the improvement of the consumption level of people, the outdoor activity frequency is gradually improved, the probability of ultraviolet injury to skin is greatly increased, and the efficacy cosmetic for repairing the ultraviolet injury becomes an indispensable product for consumers.
At present, a plurality of products for repairing ultraviolet injury exist in the market, and mainly relate to after-sun repair products. The after-sun repair product is designed mainly for the external manifestations of skin surface temperature rise, erythema, pigmentation, wrinkles and the like after ultraviolet injury, and mainly has the effects of physical cooling, relieving and calming and brightening the skin color. The skin care product is used in different steps, firstly, spray or facial mask is used for cooling the surface of the skin, then, the soothing and calming product is used for soothing the skin and relieving inflammation, and finally, the product containing the whitening component is used for brightening the skin color. The existing after-sun repair products cannot improve the immunity of cells to ultraviolet rays, and repair free radicals, cell DNA damage and the like caused by ultraviolet rays from deeper layers. Therefore, the problems of erythema, dull skin color, wrinkles and the like caused by ultraviolet ray damage cannot be fundamentally solved.
Disclosure of Invention
The invention aims to provide an active composition for repairing ultraviolet injury, which is added into a skin care product and can effectively reduce the formation of sunburn cells, inhibit the damage of ultraviolet rays to cell DNA and inhibit the increase of free radical content so as to improve the immunocompetence of cells to ultraviolet rays. The invention provides a solution for repairing ultraviolet injury from inside to outside, and the solution has better ultraviolet injury repairing effect compared with the traditional after-sun repairing product.
The technical scheme of the invention is as follows:
an active composition for repairing ultraviolet injury comprises the following raw material components: tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, saffron extract, beta-glucan and water.
The tremella polysaccharide is derived from tremella sporophore, is a kind of biogenic hyaluronic acid, and is water soluble high molecular heteropolysaccharide extracted from tremella, and has moisturizing performance superior to hyaluronic acid, excellent film forming property and smooth feeling. It has effects in enhancing cellular immunity, scavenging free radicals, resisting aging, enhancing skin moisture, and reducing skin texture.
Glycogen is prepared from waxy corn starch serving as a raw material by an enzymatic synthesis method. Can improve the ability of cell to resist ultraviolet, inhibit apoptosis caused by ultraviolet, and inhibit erythema generated by UVB irradiation; it can be used for improving wrinkle.
The hydroxyethyl piperazine ethane sulfonic acid is a very effective biological buffer, and can maintain the structure and active ingredients of biological enzymes. Can absorb UVA, has synergistic anti-photoaging effect, promotes cutin regeneration, and reduces wrinkle.
The saffron extract is a soothing anti-inflammatory active ingredient and is extracted from saffron planted in native organic agriculture of France. The saffron extract can be used for remarkably solving the discomfort of skin stabbing pain, red swelling and burning caused by ultraviolet rays, controlling skin micro-inflammation and repairing the skin damaged by ultraviolet irradiation.
Beta-glucan is fermented from baker's yeast and is a polysaccharide composed of glucose linked by glycosidic bonds. Has effects in keeping moisture, relieving stress, and promoting cell synthesis of collagen.
The inventor is dedicated to the development of after-sun repair products for a long time, and in the process of carrying out a large number of experiments and repeated exploration, the inventor discovers that the effect of compounding the 5 active substances is remarkable in the aspects of lightening the sunburn of sensitive skin and lightening erythema, and further discovers that the combination shows remarkable effects in the tests of free radical clearance rate, improving the immunity of Langerhans cells to ultraviolet rays, reducing the formation of sunburn cells and repairing the DNA damage of cells caused by ultraviolet rays through deeper research, so that the invention fully shows that the composition can repair the external problems of the skin caused by the ultraviolet rays from deeper layers, and provides a new solution for the current situation that the existing after-sun repair products are difficult to further develop in the aspect of effect.
Preferably, the raw material components comprise the following components in parts by weight: 5-10 parts of tremella polysaccharide, 20-25 parts of glycogen, 5-7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5-8 parts of beta-glucan and 50 parts of water.
Preferably, the raw material components comprise the following components in parts by weight: 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
Preferably, the raw material components comprise the following components in parts by weight: 10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
Preferably, the raw material components comprise the following components in parts by weight: 8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
Preferably, the raw material components comprise the following components in parts by weight: 8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
Preferably, the raw material components comprise the following components in parts by weight: 5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 8 parts of beta-glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury comprises the following specific steps: respectively weighing the raw materials, and stirring to dissolve uniformly.
The active composition for repairing ultraviolet injury has multiple purposes, is easy to add into essence, emulsion or cream to provide multiple effects such as after-sun repair, wrinkle resistance, brightening and the like, for example, the active composition is added into the after-sun repair essence, and the adding amount is generally 1.5-2.5wt%.
The beneficial effects of the invention are as follows:
the composition for repairing ultraviolet injury has a remarkable effect of repairing ultraviolet injury, and in vitro test results show that the composition for repairing ultraviolet injury can effectively reduce free radicals caused by ultraviolet rays, improve the immunity of Langerhans cells to ultraviolet rays, reduce the formation of sunburn cells caused by ultraviolet irradiation, and repair cell DNA damage caused by ultraviolet rays. The result of human body tests shows that the essence added with the ultraviolet injury repairing active composition can effectively reduce erythema caused by ultraviolet irradiation, effectively improve skin brightness and reduce wrinkle depth. The composition is mild, safe and non-irritant, the preparation method is simple, and the composition can be easily added into various skin care products to provide multiple functions of after-sun repair, wrinkle resistance, brightening and the like.
Drawings
FIG. 1: reducing experimental results of sunburn cell formation;
FIG. 2: repairing cell DNA damage caused by ultraviolet rays;
FIG. 3: and (4) testing the erythema value under ultraviolet irradiation.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without making any creative effort, shall fall within the protection scope of the present invention. In the following examples, 1 part by weight represents 1g.
Example 1
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTER Technopole), 5 parts of beta-glucan (Active concentrates) and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury described in this example is: respectively weighing the raw materials in parts by weight, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, a saffron extract and beta-glucan at normal temperature, and stirring to dissolve uniformly to obtain the medicine.
Example 2
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 5 parts of beta-glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury described in this embodiment is as follows: respectively weighing the raw materials in parts by weight, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, saffron extract and beta-glucan at normal temperature, and stirring to dissolve uniformly to obtain the medicine.
Example 3
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTER Technopole), 5 parts of beta-glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury described in this example is: respectively weighing the raw materials in parts by weight, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, a saffron extract and beta-glucan at normal temperature, and stirring to dissolve uniformly to obtain the medicine.
Example 4
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 5 parts of beta-glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury described in this embodiment is as follows: respectively weighing the raw materials in parts by weight, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, a saffron extract and beta-glucan at normal temperature, and stirring to dissolve uniformly to obtain the medicine.
Example 5
The embodiment provides an active composition for repairing ultraviolet injury, which is prepared from the following raw materials in parts by weight:
5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of saffron extract (ID bio ESTer Technopole), 8 parts of beta-glucan and 50 parts of water.
The preparation method of the active composition for repairing ultraviolet injury described in this embodiment is as follows: respectively weighing the raw materials in parts by weight, sequentially adding water, tremella polysaccharide, glycogen, hydroxyethyl piperazine ethane sulfonic acid, a saffron extract and beta-glucan at normal temperature, and stirring to dissolve uniformly to obtain the medicine.
Comparative example
The difference between the comparative example and the example 1 is only that the stem extract of the prickly pear with the function of relieving and repairing is used for replacing the saffron extract, and the comparative example specifically comprises the following raw materials in parts by weight: 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid (HOPAX), 10 parts of twisted cactus stem extract, 5 parts of beta-glucan and 50 parts of water.
The essence is prepared by respectively using the active compositions for repairing ultraviolet injury prepared in the above examples 1-5 and comparative examples, and the formula of the essence is as follows:
TABLE 1 essence formula
The preparation method comprises the following steps: adding water, methyl propylene glycol, glycerol and xanthan gum into a main pot, heating to 85 ℃, homogenizing and dispersing uniformly, and keeping the temperature for 30min; cooling, adding the rest raw materials at 45 deg.C, stirring and mixing; cooling to 38 deg.C and discharging.
1. Safety test
Skin patch test: the number of the tested people is 50, and all the tested people meet the standard of the testee. The UV-damage repairing active compositions of examples 1-5 and comparative examples, as well as commercially available samples (after-sun repair concentrate) were placed in the spot tester chamber at a volume of about 0.020mL to about 0.025mL. The control well is blank (containing no substance), and the patch test device with the test substance is applied to the back or forearm of the subject with hypoallergenic tape, and is applied to the skin by pressing gently with the palm for 24h. The skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test device, respectively, according to the following table standards and the observation results were recorded.
TABLE 2 skin closure Patch test skin response grading Standard
TABLE 3 test results of human skin patches
As can be seen from the test results, the composition for repairing ultraviolet injury of the invention does not cause skin allergy, and has higher skin use safety compared with the commercial product.
2. Efficacy testing
1. In vitro testing
1.1 free radical scavenging test
The test method comprises the following steps: adopts an Organotypical skin modelSkin models were pretreated with a dilution containing 2% of the inventive example and comparative repair UV-damage active composition solution, commercial samples and placebo, respectively, with pbs buffer 1 2 UVB intensity), the test results are as follows:
table 4 free radical scavenging test results
As can be seen from the above test results, the UV damage repairing active composition of the present invention can effectively reduce free radicals caused by UV.
1.2 test for improving the immunological competence of Langerhans cells to ultraviolet radiation
The test method comprises the following steps: in vivo; the medial aspect of the forearm was treated with the samples of examples 1-5, comparative examples (1.5%, 2.0%, 2.5%) and commercially available for 2 weeks (4 cm) 2 ) Comparison to placebo; UV-exposure (1.5 MED); langerhans cells were tested by ATPase histological staining sections; the test results were as follows:
TABLE 5 test results for improving the immunity of Langerhans cells to UV light
From the test results, the composition for repairing ultraviolet injury of the invention can effectively improve the immunity of the Langerhans cells to ultraviolet rays, and the effect is obviously stronger than that of a comparative example and a commercial product.
1.3 experiment for reducing formation of sunburn cells
The test method comprises the following steps:the skin model was pretreated with a dilution containing the solutions of examples and comparative examples (2%) with pbs buffer 1; 100mJ/cm 2 Ultraviolet radiation at UVB intensity; the number of sunburn cells was observed with a microscope. The test results are shown in FIG. 1. As can be seen from the test results, the active composition for repairing ultraviolet injury of the invention can effectively reduce the formation of sunburn cells caused by ultraviolet irradiation, and the effect is better than that of the comparative example and the commercial samples.
1.4 repair of UV-induced cellular DNA damage
The test method comprises the following steps: in vitro; in vitro analysis; examples 1-5, comparative (2%) solution, commercial samples and placebo were pre-incubated with HaCaT-keratinocyte cells for 24h, 5J/cm, after dilution with pbs buffer 1 2 UVA irradiation, DNA damage due to UVA was assessed. The test results are shown in FIG. 2. As can be seen from the above test results, the composition for repairing UV damage of the present invention can effectively repair UV-induced DNA damage of cells, and is superior to comparative examples and commercially available samples.
2. Trial by the consumer
2.1 erythema value test under UV irradiation
Randomly selecting 27 healthy volunteers, and respectively administering 1-6# essence, a commercially available sample and a placebo; the method comprises the following steps: 2 times a day (1 in the morning and evening), 2 hours post-application UVB irradiation for one month, and erythema values were measured using a Mexameter skin melanin and heme tester. The test results are shown in FIG. 3. From the test results, it can be seen that the essence added with the ultraviolet injury repairing active composition of the embodiment of the invention can effectively reduce erythema caused by ultraviolet irradiation, and the effect is better than that of the comparative example composition sample and the commercial sample.
2.2 skin gloss test
The test method comprises the following steps: the skin gloss tester glossimeter, the larger the value, the better the skin gloss.
20 parts of the No. 1-6 essence and a commercially available sample are respectively used by female consumers, the female consumers are aged 25-60 years, 2 times in 1 day (1 time in the morning and evening), after the application of the essence, the UVB is irradiated for 2 hours, and the gloss of the cheek parts is tested after the continuously used sample is continuously used for 1 month for one month. The test results were as follows:
table 6 skin gloss test results
From the test results, the essence added with the ultraviolet injury repairing active composition of the embodiment of the invention can effectively improve the skin brightness, and the effect is better than that of the sample added with the comparative example and the commercially available sample.
2.3 wrinkle depth reduction test
The test method comprises the following steps: the skin texture and active skin surface analysis system VC20plus, the smaller the value of the wrinkle parameter SEw is, the fewer wrinkles are represented; the No. 1-6 essence and the commercial samples are used for removing wrinkles for consumers for 1 day and 2 times, and are continuously used for 1 month, wherein the total amount is 20 parts. The test results were as follows:
table 7 wrinkle depth reduction test results
From the test results, the essence added with the ultraviolet injury repairing active composition provided by the embodiment of the invention can effectively reduce the wrinkle depth, and the effect is better than that of the essence added with the comparative example and a commercially available sample.
In summary, it can be seen from the experimental results that: 1. the active composition for repairing ultraviolet injury can effectively reduce free radicals caused by ultraviolet rays, improve the immunocompetence of Langerhans cells to the ultraviolet rays, reduce the formation of sunburn cells caused by ultraviolet irradiation, repair the DNA damage of the cells caused by the ultraviolet rays, and further solve the problem of ultraviolet injury from a deeper surface; 2. in addition, the effect is obviously weakened after the saffron extract in the composition is replaced by the prickly pear stem extract, which shows that the effect of repairing ultraviolet injury is related to the specific raw material composition of the invention and has obvious superiority compared with the prior art.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily think of the changes or substitutions within the technical scope of the present invention, and shall cover the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (9)
1. The active composition for repairing ultraviolet injury is characterized by comprising the following raw materials in parts by weight: 5-10 parts of tremella polysaccharide, 20-25 parts of glycogen, 5-7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5-8 parts of beta-glucan and 50 parts of water.
2. The active composition for repairing ultraviolet injury according to claim 1, which is prepared from the following raw materials in parts by weight: 5 parts of tremella polysaccharide, 25 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
3. The active composition for repairing ultraviolet injury according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of tremella polysaccharide, 20 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
4. The active composition for repairing ultraviolet injury according to claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of tremella polysaccharide, 22 parts of glycogen, 5 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
5. The active composition for repairing ultraviolet injury according to claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 5 parts of beta-glucan and 50 parts of water.
6. The active composition for repairing ultraviolet injury according to claim 1, which is prepared from the following raw materials in parts by weight: 5 parts of tremella polysaccharide, 20 parts of glycogen, 7 parts of hydroxyethyl piperazine ethane sulfonic acid, 10 parts of saffron extract, 8 parts of beta-glucan and 50 parts of water.
7. The preparation method of the active composition for repairing ultraviolet injury of any one of claims 1-6, which comprises the following steps: respectively weighing the raw materials, and stirring to dissolve uniformly.
8. Use of the active composition for repairing ultraviolet injury of any one of claims 1-6 in the preparation of essence, lotion or cream with sunscreen repair function.
9. The use according to claim 8, wherein the UV damage repairing active composition is added in an amount of 1.5-2.5wt%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010395701.5A CN111494264B (en) | 2020-05-12 | 2020-05-12 | Active composition for repairing ultraviolet injury, preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010395701.5A CN111494264B (en) | 2020-05-12 | 2020-05-12 | Active composition for repairing ultraviolet injury, preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111494264A CN111494264A (en) | 2020-08-07 |
CN111494264B true CN111494264B (en) | 2023-01-10 |
Family
ID=71866841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010395701.5A Active CN111494264B (en) | 2020-05-12 | 2020-05-12 | Active composition for repairing ultraviolet injury, preparation method and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111494264B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114081853B (en) * | 2021-03-26 | 2023-08-04 | 太和康美(北京)中医研究院有限公司 | Plant composition and preparation method and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110151612B (en) * | 2019-07-02 | 2022-05-10 | 上海美浮特生物科技有限公司 | Anti-photoaging composition and application thereof in essence |
CN110279602A (en) * | 2019-07-12 | 2019-09-27 | 上海美浮特生物科技有限公司 | Skin repair composition, preparation method, and the application in cosmetics |
-
2020
- 2020-05-12 CN CN202010395701.5A patent/CN111494264B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN111494264A (en) | 2020-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107213063B (en) | Fair and bright facial mask and preparation method thereof | |
WO2010067212A2 (en) | A complex of active vegetal stem cells and a cosmetic composition | |
CN109893464A (en) | It is a kind of to block the whitening spot-removing skin care item and preparation method thereof for inhibiting reduction melanin | |
CN107456415B (en) | Whitening and brightening composition | |
CN113081890A (en) | Essence with anti-sugar and anti-oxidation functions and preparation method thereof | |
CN112842960A (en) | Cosmetic composition with ultraviolet resistance, whitening and aging resistance | |
CN111494264B (en) | Active composition for repairing ultraviolet injury, preparation method and application thereof | |
KR101727788B1 (en) | Sargassum thunbergii hydrolysates that have high glucuronic acid cotent, preparation method thereof and antiaging cosmetic composition containing the same | |
CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
CN108014060B (en) | Sunscreen synergistic composition and application thereof | |
KR101639578B1 (en) | Cosmetic composition containing Ocimum basilicum seed extract | |
JP2023171950A (en) | Anti-aging agent, antioxidant, anti-inflammatory agent, and whitening agent, as well as cosmetic | |
CN112656731A (en) | Composition with red-repairing effect and preparation method and application thereof | |
CN112245348A (en) | Skin-care cream and preparation method thereof | |
CN111297733A (en) | Paeonol-containing high-moisture-retention sun-screening agent and preparation method thereof | |
CN113633599B (en) | Skin foundation essence containing dendrobium officinale extract and preparation method thereof | |
KR20140081138A (en) | A skin-care agent containig Antrodia camphorata fruit body extract or Antrodia camphorata mycelium extract | |
KR101402193B1 (en) | Cosmetic composition for skin whitening containig pleurotus ferulae fruit body extract or pleurotus ferulae mycelium extract or pleurotus ferulae mycelium culture fluid | |
US11110117B2 (en) | Skin preparation composition for external use containing complex hyaluronic acid | |
CN111053721B (en) | Silky glowing eye cream and preparation method thereof | |
CN108969465B (en) | Refreshing, relaxing and isolating sun block and preparation method thereof | |
CN113876671A (en) | Anti-aging composition containing rape bud extract and preparation method thereof | |
KR101458496B1 (en) | A skin-care agent for anti-inflammatory containig Pleurotus ferulae fruit body extract or Pleurotus ferulae mycelium extract or Pleurotus ferulae mycelium culture fluid | |
CN108888573B (en) | Soothing and moisturizing cream and preparation method thereof | |
CN108653144B (en) | Whitening cosmetic |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |