CN108653144B - Whitening cosmetic - Google Patents
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- CN108653144B CN108653144B CN201810759731.2A CN201810759731A CN108653144B CN 108653144 B CN108653144 B CN 108653144B CN 201810759731 A CN201810759731 A CN 201810759731A CN 108653144 B CN108653144 B CN 108653144B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a whitening cosmetic. The invention takes a plurality of plant extracts as raw materials, wherein the plant extracts comprise bletilla striata extract, cannabis oil, sumac oil, notoginsen triterpenes, sumac flower extract and notoginseng flower extract. The composite material is prepared from the following raw materials in parts by weight: 5-10 parts of bletilla striata extract, 5-10 parts of hemp oil, 5-10 parts of sumac oil, 5-10 parts of notoginsen triterpenes, 5-10 parts of sumac flower extract, 5-10 parts of notoginseng flower extract, 10-20 parts of other components and 20-60 parts of deionized water. The whitening cosmetic is mainly prepared from natural vegetable oil and plant extracts, is green and safe, and has no stimulation to skin; the composition can be used in whitening formula, and has effects of whitening skin, moistening skin, resisting bacteria and diminishing inflammation.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a whitening cosmetic.
Background
The beauty of the skin is the nature of each person, the state and appearance of the skin are important components, and healthy and fair skin is sought. Therefore, the demand for whitening cosmetics has been leading to the demand for various cosmetics.
Skin tissue is the first protective barrier in humans and can be broadly divided into epidermal, dermal and subcutaneous tissue. The color of skin is determined mainly by the amount, size and distribution of melanin contained in skin cells.
The problem of skin lightening is mainly dependent on the ability of melanocytes to synthesize melanin. Melanocytes are distributed among basal layer cells of human epidermis, and tyrosinase contained in the melanocytes can oxidize tyrosine into polysaccharide, wherein the tyrosinase is polyphenol transferase and belongs to the class of redox enzymes, and finally melanin can be generated through a series of metabolic processes. The more melanin production, the darker the skin; otherwise, the whiter the skin. Tyrosinase has unique dual catalytic functions, is a key enzyme for melanin synthesis in organisms, and has close relation with human aging. Abnormal overexpression of this gene can lead to pigmentation disorders in humans. The tyrosinase inhibitor can be used for treating pigmentation dermatoses such as freckle, chloasma, and senile plaque. Therefore, arbutin, vitamin C derivatives, kojic acid and derivatives thereof, green tea extract, licorice extract and other traditional Chinese medicine extracts in the currently popular whitening cosmetics in the market are tyrosinase inhibitors, and the tyrosinase inhibitors mainly inhibit the synthesis of melanin by inhibiting the activity of tyrosinase, thereby playing a role in whitening.
In a whitening composition disclosed in patent CN201010214873.4, the composition contains a white mulberry root-bark extract, a chamomile extract, a rhodiola rosea extract, a grape seed extract, a licorice extract, a morus alba extract, arbutin, kojic acid dipalmitate, niacinamide, tetrahydrocurcumin, a humectant and a preservative.
In patent CN201310210916.5, a whitening plant extract composition and its application in cosmetics, a plant composition with whitening function and its application in whitening cosmetics are disclosed, the plant composition of the invention is prepared by compounding cortex mori extract, licorice extract, peony extract, kapok extract, angelica sinensis extract and cortex moutan extract. The plant composition can be used in a whitening formula, and has the functions of inhibiting tyrosinase activity, removing free radicals and whitening skin.
In a patent CN201210511695.0, a whitening cosmetic and a preparation method thereof, a whitening cosmetic is disclosed, which is prepared from the following raw materials in percentage by weight: 50-70 wt% of cucumber seed oil, 15-25 wt% of St.John's wort oil and 15-25 wt% of calendula oil, and the preparation method comprises the following steps: mixing 50-70 wt% of cucumber seed oil, 15-25 wt% of john's wort oil and 15-25 wt% of calendula oil at the temperature of 20-25 ℃, and uniformly stirring to obtain a product; the whitening cosmetic disclosed by the invention is prepared from natural vegetable oil, is green and safe, and has no stimulation to skin.
As for whitening cosmetics, China has rich plant resources, can fully utilize modern biotechnology to extract active ingredients in animals and plants, comprehensively research whitening mechanisms, scientifically combine the active ingredients and complement each other, can obtain various natural cosmetics to achieve the effect of whitening skin, and has important practical significance for enriching the whitening cosmetics in China and promoting the cosmetic industry in China.
According to the patent method disclosed by the invention, the whitening cosmetics prepared by compounding the bletilla striata extract, the cannabis sativa oil, the sumac oil, the panax notoginseng stem and leaf saponin, the sumac flower extract, the panax notoginseng flower extract and other plant extracts are searched through documents and patents in a domestic range, and no report is found.
The existing whitening cosmetics mainly have the following problems and defects: (1) some whitening cosmetics have irritation to the skin because they often contain chemical components such as acids, alkalis, salts, surfactants, etc. After acting on the mucous membrane of skin and organs, the chemical substances often cause irritant skin lesions, also called irritant contact dermatitis, which is the most common skin damage caused by whitening cosmetics and is also acute inflammation which rapidly appears on the local part of the skin. In addition, some components in the whitening product can be deposited in the body and can not be excreted, which can cause unsmooth blood, skin aging, acne, color spots, sallow skin, wrinkle increase, relaxation, skin metabolism reduction and the like. Even enter the fetus through the placenta, thus harming the development of the nervous system of the fetus and causing adverse effects.
(2) The product stability is low, and not only a few of the anti-oxidation chemical functional components of the whitening cosmetics have one or a plurality of unsaturated double bonds, but the functional components can play a role in inhibiting melanin in the skin due to strong reducibility, but when the active components are prepared into finished products of the cosmetics, the unsaturated bonds are denatured and inactivated under the action of oxygen, light, metal ions and the like and lose whitening activity due to exposure in the air for a month or even a few days, so that the whitening effect is poor.
(3) The whitening pathway is single, melanin is generated through a series of complex chemical reactions, and multiple pathways can inhibit the generation of the melanin. Most of the whitening products in the current cosmetic market only mainly comprise tyrosinase inhibitors, and new compounds are discovered at a higher speed every year. However, each of the whitening additives can only inhibit one pathway, but cannot fully inhibit melanin.
(4) In order to reflect the effect of the existing whitening cosmetic products, various chemical components and using hormones are intentionally added, although the whitening cosmetic products have whitening effect on skin and can reduce wrinkles, some cosmetic enterprises can add forbidden substances (such as antibiotics) into the products. After long-term use of these hormone-containing cosmetics, the skin is affected by hormone dependence, even systemic damage, and hormone-dependent inflammatory skin reactions such as pigmentation, including erythema, pimple, exudation, telangiectasia, etc., may occur when the cosmetics are not used.
In light of the above-mentioned shortcomings, the present invention is mainly improved and optimized from the following aspects: (1) adopts pure natural non-chemical modification or synthesis components. The application of the compounds is reduced as much as possible on the premise of ensuring that the product has better whitening efficacy, and the problems caused by the compounds can be obviously improved.
(2) The pure natural, mild and neutral plant extracts can be added into the formula, so that the product achieves the whitening effect, simultaneously reduces the irritation, and really achieves the purpose of safe whitening.
(3) Combining different approaches, the whitening active ingredients are scientifically formulated to comprehensively whiten the skin, and melanogenesis is inhibited from different approaches in many ways, so that the purpose of comprehensive whitening is finally achieved.
(4) The cosmetics prepared according to the formula components and the preparation method of the invention have the main functions of whitening, and in addition, have the effects of moistening skin, resisting wrinkles, resisting bacteria and diminishing inflammation.
Disclosure of Invention
The invention aims to obtain a whitening cosmetic which has no irritation to human skin, good whitening effect, strong functionality and high safety by utilizing certain biological resource extracts with local characteristics in Yunnan. The composite material is prepared from the following raw materials in parts by weight: 5-10 parts of bletilla striata extract, 5-10 parts of hemp oil, 5-10 parts of sumac oil, 5-10 parts of notoginsen triterpenes, 5-10 parts of sumac flower extract, 5-10 parts of notoginseng flower extract, 10-20 parts of other components and 20-60 parts of deionized water.
The composition also contains other auxiliary materials, and the other components are hemicellulose, glycerol, 1, 3-propylene glycol, sodium hyaluronate, carbomer, triethanolamine, allantoin, nano titanium dioxide, corn peptide liquid, an antibacterial agent, glutathione and an emulsifier.
The sumac flower extract is prepared by drying and crushing a certain amount of fresh sumac flowers, refluxing and extracting crushed substances by using an ethyl acetate solution, and concentrating and drying an extracting solution, wherein the mass percent concentration of the ethyl acetate solution is 40-70%.
The pseudo-ginseng flower extract is prepared by drying and crushing a certain amount of fresh pseudo-ginseng flowers, extracting the crushed substances by refluxing with an ethyl acetate solution, concentrating and drying the extracting solution, wherein the mass percentage concentration of the ethyl acetate solution is 20-40%.
The lacquer tree oil is lacquer tree seed kernel oil.
The hemicellulose, the glycerol, the 1, 3-propylene glycol, the sodium hyaluronate, the carbomer, the triethanolamine, the allantoin, the nano titanium dioxide, the corn peptide liquid, the antibacterial agent, the glutathione and the emulsifier are all conventional commercially available products.
The method has the advantages and the technical effects that: 1. the product obtained by the invention makes high value-added utilization of plant extracts such as bletilla striata, fructus cannabis, sumac seeds, pseudo-ginseng stems and leaves, sumac flowers, pseudo-ginseng flowers and hemicellulose, and is a natural whitening cosmetic.
2. The cosmetic and the preparation method thereof have the characteristics of simple process, low cost, obvious effect after compound emulsification and good safety.
3. The formulated cosmetic can be used as whitening product such as emulsion, essence, and ointment by different blending methods.
The present invention is further illustrated in detail by the following examples, but the scope of the present invention is not limited to the above-described contents, and in the examples, unless otherwise specified, all methods used are conventional methods, and all reagents used are conventional commercially available reagents.
Detailed Description
Example 1 the whitening cosmetic composition is prepared from the following raw materials in parts by weight: 5 parts of bletilla striata extract, 5 parts of hemp oil, 5 parts of sumac oil, 5 parts of panax notoginseng stem and leaf saponin, 5 parts of sumac flower extract, 5 parts of panax notoginseng flower extract, 10 parts of other components and 60 parts of deionized water. Other components comprise 0.5 part of hemicellulose, 2 parts of glycerol, 1 part of 1, 3-propylene glycol, 0.2 part of sodium hyaluronate, 0.1 part of carbomer, 0.1 part of triethanolamine, 0.1 part of allantoin, 0.1 part of nano titanium dioxide, 0.5 part of corn peptide liquid, 0.1 part of antibacterial agent (phenoxyethanol), 0.3 part of glutathione and 5 parts of emulsifier (wheat emulsifying wax).
The preparation method of the product comprises the following steps: (1) mixing sodium hyaluronate, allantoin, glutathione and corn peptide liquid, adding glycerol and 1, 3-propylene glycol, and stirring and mixing uniformly for later use;
(2) uniformly stirring hemp seed oil, lacquer tree oil and an emulsifier (wheat emulsifying wax) at a stirring speed of 50r/min and a temperature of 70 ℃ for later use;
(3) adding hemicellulose and nano titanium dioxide into a container, and then mixing the materials according to a solid-to-liquid ratio of 1: 25, adding water, heating to 70 ℃, stirring at a speed of 50r/min for 10min, and stirring until the water is completely dissolved for later use;
(4) taking carbomer and triethanolamine, and mixing the carbomer and the triethanolamine in water according to the solid-to-liquid ratio of 1: 60 soaking in water, stirring and mixing to obtain uniform gel;
(5) uniformly mixing the mixture obtained in the step 1), the step 2), the step 3) and the step 4) and then uniformly stirring;
(6) adding bletilla striata extract, panax notoginseng stem and leaf saponin, sumac flower extract, panax notoginseng flower extract and antibacterial agent (phenoxyethanol) into the mixture obtained in the step 5), supplementing the rest water, and stirring and mixing uniformly;
(7) pumping the mixture obtained in the step 6) into a homogenizer, vacuumizing to-0.04 MPa, stirring, homogenizing at the rotation speed of the homogenizer of 1000r/min for 5 min;
(8) and (3) carrying out closed ageing on the homogeneous mixture obtained in the step 7) at normal temperature for 12h, and obtaining the whitening and skin moistening emulsion after the ageing is finished.
The related indexes after the method is used are determined by a conventional detection method, wherein the tyrosinase activity determination method adopts a Mushroom tyrosinase dopa rate oxidation method, the scavenging effect of superoxide anion free radicals and the scavenging effect of hydroxyl free radicals are respectively determined by a spectrophotometry, and specific index data are as follows: experimental project inhibition rate (%) 85.834.653.2 of scavenging effect of tyrosinase activity inhibition on superoxide anion free radicals on scavenging of hydroxyl free radicals
The PFA value (long-wave uv protection index of sunscreen cosmetic) and the SPF value (sun protection factor) were measured, and the PFA value and the SPF value were PFA value 7 and SPF15, respectively.
The detection result shows that the whitening and skin-moistening emulsion can effectively inhibit the activity of tyrosinase and remove free radicals after being used for a long time, effectively slow down the synthesis speed of melanin, has good effects on ultraviolet absorption and skin sunscreen, has the effects of moisturizing, skin-care and whitening, and has safety and no irritation to human skin.
Example 2 the whitening cosmetic composition is prepared from the following raw materials in parts by weight: 10 parts of bletilla striata extract, 10 parts of hemp oil, 10 parts of sumac oil, 10 parts of panax notoginseng stem and leaf saponin, 10 parts of sumac flower extract, 10 parts of panax notoginseng flower extract, 20 parts of other components and 20 parts of deionized water. Other components comprise 0.2 part of hemicellulose, 3 parts of glycerol, 1 part of 1, 3-propylene glycol, 0.3 part of sodium hyaluronate, 0.1 part of carbomer, 0.1 part of triethanolamine, 0.2 part of allantoin, 0.2 part of nano titanium dioxide, 2.5 parts of corn peptide liquid, 0.1 part of antibacterial agent (phenoxyethanol), 0.3 part of glutathione, and 12 parts of emulsifier (Tween 80)
The preparation method of the product comprises the following steps:
(1) mixing sodium hyaluronate, allantoin, glutathione and corn peptide liquid, adding glycerol and 1, 3-propylene glycol, and stirring and mixing uniformly for later use;
(2) stirring oleum Sesami, lacquer tree oil and emulsifier (Tween 80) at stirring speed of 50r/min and temperature of 80 deg.C, and stirring well for use;
(3) adding hemicellulose and nano titanium dioxide into a container, and then mixing the materials according to a solid-to-liquid ratio of 1: 30, adding water, heating to 75 ℃, stirring at the speed of 150r/min for 5min, and stirring until the water is completely dissolved for later use;
(4) taking carbomer and triethanolamine, and mixing the carbomer and the triethanolamine in water according to the solid-to-liquid ratio of 1: 30 soaking in water, stirring and mixing to obtain uniform gel;
(5) uniformly mixing the mixture obtained in the step 1), the step 2), the step 3) and the step 4) and then uniformly stirring;
(6) adding bletilla striata extract, panax notoginseng stem and leaf saponin, sumac flower extract, panax notoginseng flower extract and antibacterial agent (phenoxyethanol) into the mixture obtained in the step 5), supplementing the rest water, and stirring and mixing uniformly;
(7) pumping the mixture obtained in the step 6) into a homogenizer, vacuumizing to-0.04 MPa, stirring, homogenizing at 2000r/min for 5 min;
(8) and (3) carrying out closed ageing on the homogeneous mixture obtained in the step 7) at normal temperature for 24h, and obtaining the whitening cream after the ageing is finished.
The related indexes after the method is used are determined by a conventional detection method, wherein the tyrosinase activity determination method adopts a Mushroom tyrosinase dopa rate oxidation method, the scavenging effect of superoxide anion free radicals and the scavenging effect of hydroxyl free radicals are respectively determined by a spectrophotometry, and specific index data are as follows: experimental project inhibition rate (%) 88.845.256.2 of scavenging effect of tyrosinase activity inhibition on superoxide anion free radicals on scavenging of hydroxyl free radicals
When the PFA value (long-wave uv protection index of sunscreen cosmetic) and the SPF value (sun protection factor) were measured, the PFA value and the SPF value were PFA value 8 and SPF15, respectively.
The detection result shows that the whitening cream can effectively inhibit the activity of tyrosinase and remove free radicals after being used for a long time, effectively slow down the synthesis speed of melanin, has good effects on ultraviolet absorption and skin sunscreen, has the effects of moisturizing, skin care and whitening, and has safety and no irritation to human skin.
Example 3 the whitening cosmetic composition is prepared from the following raw materials in parts by weight: 6 parts of bletilla striata extract, 6 parts of hemp oil, 6 parts of sumac oil, 5 parts of panax notoginseng stem and leaf saponin, 5 parts of sumac flower extract, 5 parts of panax notoginseng flower extract, 13 parts of other components and 54 parts of deionized water. The preparation method of the corn peptide liquid comprises the following steps of preparing other components of 0.3 part of hemicellulose, 3 parts of glycerol, 1 part of 1, 3-propylene glycol, 0.2 part of sodium hyaluronate, 0.1 part of carbomer, 0.1 part of triethanolamine, 0.1 part of allantoin, 0.1 part of nano titanium dioxide, 0.5 part of corn peptide liquid, 0.1 part of antibacterial agent (phenoxyethanol), 0.5 part of glutathione, and 6 parts of emulsifying agent (sibirak S305 and olive emulsifying wax in a mass ratio of 1:1), wherein the preparation method comprises the following steps:
(1) mixing sodium hyaluronate, allantoin, glutathione and corn peptide liquid, adding glycerol and 1, 3-propylene glycol, and stirring and mixing uniformly for later use;
(2) uniformly stirring the cannabis oil, the sumac oil and an emulsifier (Saibake S305 and olive emulsifying wax in a mass ratio of 1:1) at a stirring speed of 50r/min and a temperature of 80 ℃ for later use;
(3) adding hemicellulose and nano titanium dioxide into a container, and then mixing the materials according to a solid-to-liquid ratio of 1: 50, adding water, heating to 75 ℃, stirring at the speed of 150r/min for 5min, and stirring until the water is completely dissolved for later use;
(4) taking carbomer and triethanolamine, and mixing the carbomer and the triethanolamine in water according to the solid-to-liquid ratio of 1: 60 soaking in water, stirring and mixing to obtain uniform gel;
(5) uniformly mixing the mixture obtained in the step 1), the step 2), the step 3) and the step 4) and then uniformly stirring;
(6) adding bletilla striata extract, panax notoginseng stem and leaf saponin, sumac flower extract, panax notoginseng flower extract and antibacterial agent (phenoxyethanol) into the mixture obtained in the step 5), supplementing the rest water, and stirring and mixing uniformly;
(7) pumping the mixture obtained in the step 6) into a homogenizer, vacuumizing to-0.04 MPa, stirring, homogenizing at 2000r/min for 5 min;
(8) and (3) carrying out closed ageing on the homogeneous mixture obtained in the step 7) at normal temperature for 24h, and obtaining the whitening skin cream after the ageing is finished.
The related indexes after the method is used are determined by a conventional detection method, wherein the tyrosinase activity determination method adopts a Mushroom tyrosinase dopa rate oxidation method, the scavenging effect of superoxide anion free radicals and the scavenging effect of hydroxyl free radicals are respectively determined by a spectrophotometry, and specific index data are as follows: experimental project inhibition rate (%) 82.433.254.1 of scavenging effect of tyrosinase activity inhibition on superoxide anion free radicals on scavenging of hydroxyl free radicals
The PFA value (long-wave uv protection index of sunscreen cosmetic) and the SPF value (sun protection factor) were measured, and the PFA value and the SPF value were PFA value 7 and SPF15, respectively.
The detection result shows that the whitening and moisturizing cream can effectively inhibit the activity of tyrosinase and remove free radicals after being used for a long time, effectively slow down the synthesis speed of melanin, has good effects on ultraviolet absorption and skin sunscreen, has the effects of whitening, moisturizing, resisting bacteria and diminishing inflammation, and has safety and no irritation to human skin.
Example 4 the whitening cosmetic composition is prepared from the following raw materials in parts by weight: 8 parts of bletilla striata extract, 8 parts of hemp oil, 8 parts of sumac oil, 7 parts of panax notoginseng stem and leaf saponin, 7 parts of sumac flower extract, 6 parts of panax notoginseng flower extract, 12 parts of other components and 44 parts of deionized water. Other components comprise 0.3 part of hemicellulose, 4.5 parts of glycerol, 2 parts of 1, 3-propylene glycol, 0.2 part of sodium hyaluronate, 0.1 part of allantoin, 0.1 part of nano titanium dioxide, 0.5 part of corn peptide liquid, 0.1 part of antibacterial agent (phenoxyethanol), 0.2 part of glutathione and 4 parts of emulsifier (sibirak S305 and olive emulsifying wax in a mass ratio of 1: 1).
The preparation method of the product comprises the following steps: (1) adding sodium hyaluronate, allantoin, glutathione and corn peptide liquid into a mixed oil phase of glycerol and 1, 3-propylene glycol, and stirring and uniformly mixing for later use;
(2) uniformly stirring the cannabis oil, the sumac oil and an emulsifier (Saibake S305 and olive emulsifying wax in a mass ratio of 1:1) at a stirring speed of 50r/min and a temperature of 70 ℃ for later use;
(3) adding hemicellulose and nano titanium dioxide into a container, and then mixing the materials according to a solid-to-liquid ratio of 1: 35 adding water, heating to 70 ℃, stirring at a speed of 50r/min for 10min, and stirring until the water is completely dissolved for later use;
(4) uniformly stirring the mixture obtained in the steps 1), 2) and 3);
(5) adding bletilla striata extract, panax notoginseng stem and leaf saponin, sumac flower extract, panax notoginseng flower extract and antibacterial agent (phenoxyethanol) into the mixture obtained in the step 4), supplementing the rest water, and stirring and mixing uniformly;
(6) pumping the mixture obtained in the step 5) into a homogenizer, vacuumizing to-0.04 MPa, stirring, homogenizing for 5min, and controlling the rotating speed of the homogenizer to be 1000 r/min;
(7) and (3) carrying out closed ageing on the mixture obtained in the step 6) at normal temperature for 36h, and obtaining the whitening cream after the ageing is finished.
The related indexes after the method is used are determined by a conventional detection method, wherein the tyrosinase activity determination method adopts a Mushroom tyrosinase dopa rate oxidation method, the scavenging effect of superoxide anion free radicals and the scavenging effect of hydroxyl free radicals are respectively determined by a spectrophotometry, and specific index data are as follows: experimental project inhibition rate (%) 82.833.651.2 of scavenging effect of tyrosinase activity inhibition on superoxide anion free radicals on scavenging of hydroxyl free radicals
When the PFA value (long-wave uv protection index of sunscreen cosmetic) and the SPF value (sun protection factor) were measured, the PFA value and the SPF value were PFA 6 and SPF15, respectively.
The detection result shows that the whitening cream can effectively inhibit the activity of tyrosinase and remove free radicals after being used for a long time, effectively slow down the synthesis speed of melanin, has good effects on ultraviolet absorption and skin sunscreen, has the effects of whitening, moisturizing, resisting bacteria and diminishing inflammation, and has safety and no irritation to human skin.
Claims (1)
1. The whitening cosmetic is characterized by being prepared from the following raw materials: 5-10 parts of bletilla striata extract, 5-10 parts of hemp oil, 5-10 parts of sumac oil, 5-10 parts of notoginsen triterpenes, 5-10 parts of sumac flower extract, 5-10 parts of notoginseng flower extract, 10-20 parts of other components and 20-60 parts of deionized water;
the other components are hemicellulose, glycerol, 1, 3-propylene glycol, sodium hyaluronate, carbomer, triethanolamine, allantoin, nano titanium dioxide, corn peptide liquid, an antibacterial agent, glutathione and an emulsifier;
the lacquer tree oil is lacquer tree seed kernel oil;
the sumac flower extract is prepared by drying and crushing a certain amount of fresh sumac flowers, refluxing and extracting crushed substances by using an alcoholic solution or an ethyl acetate solution, and concentrating and drying an extracting solution, wherein the mass percentage concentration of the alcoholic solution or the ethyl acetate solution is 40-70%;
the notoginseng flower extract is prepared by drying and crushing a certain amount of fresh notoginseng flowers, extracting the crushed material by refluxing with an alcohol solution or an ethyl acetate solution, and concentrating and drying an extracting solution, wherein the mass percentage concentration of the alcohol solution or the ethyl acetate solution is 20-40%.
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| KR20140060924A (en) * | 2012-11-13 | 2014-05-21 | 주식회사 나우코스 | Cosmetic composition of powder type |
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| CN102302423B (en) * | 2011-08-26 | 2013-01-30 | 广东丸美生物技术股份有限公司 | Micro-emulsion matrix for whitening cosmetics and preparation method for micro-emulsion matrix |
| CN104027293B (en) * | 2014-06-27 | 2018-07-13 | 高宝化妆品（中国）有限公司 | A kind of skin-lightening cosmetic and preparation method thereof |
| CN104147064A (en) * | 2014-08-15 | 2014-11-19 | 中国林业科学研究院林产化学工业研究所 | Lacquer tree polyphenol extract capable of inhibiting activity of tyrosinase and preparation method thereof |
| CN105769691A (en) * | 2016-04-07 | 2016-07-20 | 景东旭 | Herbal skin care product |
| CN107137295A (en) * | 2017-07-06 | 2017-09-08 | 王文军 | A kind of drug ingedient whitening spot-removing crease-resistant anti-aging composition and cosmetics |
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2018
- 2018-07-11 CN CN201810759731.2A patent/CN108653144B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140060924A (en) * | 2012-11-13 | 2014-05-21 | 주식회사 나우코스 | Cosmetic composition of powder type |
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