KR20140060924A - Cosmetic composition of powder type - Google Patents

Abstract

The present invention relates to a powder-type cosmetic composition. More specifically, the present invention provides a powder-type cosmetic composition which is less sticky and is excellently spreadable so that the tangling of hair is minimized. The composition can also be easily coated and be excellently spread on hair so that a user can make a desired hairstyle on his/her hair.

Description

[0001] Cosmetic composition of powder type [0002]

The present invention relates to a powdered cosmetic composition, and more particularly, to a liposome cosmetic composition comprising an encapsulated functional material.

The hair is made up of three layers, from the outermost layer of hair to the outer layer of hair, fur, and hair. The main part of the hair, the follicle, is composed of a macromolecular protein, which is mostly elastic, called keratin. Keratin in hair is linked to a polypeptide composed of various amino acids. The polypeptide and lipopeptide are polymeric substances with side chains such as cystine bond, salt bond, and hydrogen bond. The content of sulfur is higher than that of other proteins . Because the hair is composed of keratin with this structure, it has elasticity and has the property of returning to its original shape even if bent.

On the other hand, hair plays an important role in showing the characteristics of male and female aesthetics, so that even the same person can give another impression by changing the hairstyle. As a result, a formulation capable of providing shine to the hair and easily styling the hair while arranging the hair that has been matched has been developed and used.

As a hair styling agent which facilitates the arrangement and styling of such hair, there is a hair styling agent such as hair mousse, an aerosol correcting agent such as a hair spray (see Bilek, Doris., Cosmetics & Toiletries, Vol, 99, September 1984, 57-60, 62-67 ), Emulsion type hair cream, hair lotion, oil repellent such as pomade, hair liquid, hair styling wax and the like. The styling effect and gloss of these formulations vary depending on the formulation.

Among them, cream or solid hair styling agent gives proper shine to the hair, has natural setting power, and it makes it possible to rebalance the broken hair. However, hair styling agents conventionally used are very sticky, and it is not easy to coat on palms or hair. In addition, since it is not uniformly applied to the hair, there is a problem that the setting effect is lowered and the hair looks dirty or greasy.

KR 10-2005-0027180 A, March 18, 2005

Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a hair styling composition which is low in tackiness and excellent in spreadability, minimizes the aggregation of hair, is easy to apply, To provide a powdery cosmetic composition containing the same.

More particularly, it is an object of the present invention to maximize the efficacy of an active ingredient by mixing an active ingredient contained in each functional material immediately after the hair is dissolved by dissolving the encapsulated functional material in a liquid state at a constant pressure, The present invention provides a cosmetic composition stabilized with a liposome which is easy to apply because of low tackiness and excellent in spreadability on hair and can easily produce a desired hair style.

In order to achieve the above object, the present invention provides a liposome cosmetic composition comprising an encapsulated functional material.

Hereinafter, the present invention will be described in detail.

The present invention

1 to 15% by weight of silica silicate; Vinyl pyrrolidone / vinyl acetate copolymer (VP / VA Copolymer), octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer, and acrylate / octylacrylamide copolymer 0.01 to 20% by weight of at least one film former selected from Acrylates / Octylacrylamide Copolymer; And 1 to 15% by weight of a functional material; and the remainder is a solvent containing water.

In addition,

1 to 15% by weight of silica silicate; Vinyl pyrrolidone / vinyl acetate copolymer (VP / VA Copolymer), octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer, and acrylate / octylacrylamide copolymer 0.01 to 20% by weight of at least one film former selected from Acrylates / Octylacrylamide Copolymer; And 1 to 15% by weight of a functional material, and the remainder being a water-containing solvent, wherein 0.1 to 10 parts by weight of modified starch is added to 100 parts by weight of the whole composition Thereby providing a cosmetic composition.

In the present invention, 'liposome' means a spherical structure in which a film composed of one or more ply forms a multilayer in the form of a circular droplet, and the liposome may include a plurality of encapsulated spherical structures, Means that the average particle size is from 3,000 to 10,000 nm.

In the present invention, 'encapsulation' refers to a spherical structure forming a monolayer prepared to contain the desired material in a single closed compartment, meaning that the average particle size is 1 to 500 nm.

A liposome according to an embodiment of the present invention includes a first layer including a functional material including a functional material and a water-receiving portion; A second layer of silica silicate formed on the surface of the first layer; And a third layer of a film forming agent formed on the surface of the second layer. The term " liposome " means a liposome having a particle size of 3,000 to 10,000 nm.

In the present invention, 'styling' means fixing or maintaining the shape of the hair style, but is not limited thereto.

The silica silicate according to an embodiment of the present invention may have a specific surface area of 100 m 2 / g or more and a fractionation rate of 50% or more. If the silica silicate has a specific surface area of less than 100 m 2 / g, It becomes impossible to sufficiently pulverize the aqueous phase components, and when silica silicate having a fractionalization rate of less than 50% is used, there is a problem that the affinity with the water phase component increases and the powder can not be stabilized.

According to one embodiment of the present invention, the silica silicate is a fine particulate silica having a specific surface area of 100 m 2 / g and is hydrophobically treated to use commercially available Cabosi1 TS-530 (manufactured by Cabot), Aerosil R-972 and Aerosil R-812S But is not limited thereto.

It is preferable that the cosmetic composition according to the present invention contains 1 to 15% by weight of silica silicate, and if it is less than 1% by weight, it is impossible to sufficiently pulverize the aqueous phase components, while excess amount of more than 15% When it is added, it is not possible to sufficiently liquefy when the prepared cosmetic composition is applied, and there is a problem that cloudiness remains after use, which is not preferable.

The film forming agent according to one embodiment of the present invention may include a vinylpyrrolidone / vinyl acetate copolymer (VP / VA Copolymer), an octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer (Octylacrylamide / Acrylates / Butylaminethyl Methylate Copolymer, and Acrylates / Octylacrylamide Copolymer. The cosmetic composition of the present invention can maintain hair setting power, improve bulkiness, improve appearance, and impart desired feel properties to cosmetic compositions. .

In the cosmetic composition of the present invention, the content of the film-forming agent may be 0.01 to 20% by weight. If the amount is less than 0.01% by weight, the effect of improving color development and durability due to film formation is insignificant. If the content is more than 20% by weight, the hair becomes stiff during use and no conditioning effect is exhibited. There is a problem that stickiness is left on the hand and it can be uncomfortable.

The starch is generally selected from natural unmodified starches such as corn, amylose, corn, potato, tapioca, sweet potato, rice, glutinous rice and wheat having an amylose content of 40% or less, acetic acid starch modified by physical, chemical or biological methods, Starch, acid-treated starch, acetic acid adipic acid starch, ether starch, and ester starch.

The starch according to an embodiment of the present invention may be modified starch modified by physical, chemical, or biological methods, alone or in combination.

The modified starch is further stabilized in a formulation containing a cosmetic composition such that the functional ingredient is prevented from being separated, and this stabilizes the functional substance from the external environment such as a temperature change more stably and stabilizes it in the form of particles, It is possible to mix the active ingredients contained in the respective functional materials immediately after the hair is dissolved and absorb them into the scalp, thereby maximizing the efficacy of the active ingredients.

In addition, the modified starch also serves as an esthetic enhancer in order to provide a smoother and softer agent as well as an effect of improving richness or fluidity in a hair styling lotion and cream, which is one example of a preparation containing a cosmetic composition.

The solvent according to an embodiment of the present invention may include at least one polyol selected from glycerin, sorbitol, trehalose, maltitol, and sodium hyaruronate in addition to water.

The water used for preparing the cosmetic composition of the present invention is preferably, but not limited to, deionized distilled water.

The polyol dissolves the functional material and moisturizes the skin without using an emulsifier in the cosmetic composition of the present invention. If the content of the polyol is less than 0.1% by weight, moisture resistance to the skin is weak and the functional material is not sufficiently dissolved There is a problem, and if it exceeds 20% by weight, there is a problem that a powder is not sufficiently formed.

The polyol may be at least one selected from glycerin, sorbitol, trehalose, maltitol and sodium hyaruronate, preferably maltitol or glycerin, for the purpose of skin stability and spreadability in skin application. It is not.

The functional material according to one embodiment of the present invention may include a mixture of keratin, desserts, silk sericin, and Rhus verniciflua extract.

Polygonum multiflorum Thunb. Contains anthraquinone derivatives whose main components are chrysophanic acid, chrysophanol, emodin, anthronene, lane rhein, and starch. It is used in skin diseases such as omia and eczema. It is known to inhibit skin pruritus caused by allergy and to prevent aging through antioxidant and astringent action.

Sauce can be used as it is in a natural state, in a dry state or in a dried state or in a powder state, and can be extracted by a conventional extraction method such as hot water extraction or an organic solvent.

A typical method for producing a natural extract used in the cosmetic composition of the present invention is a method for preparing a natural extract of the present invention by dissolving the dried plant in water, about 3 to 20 times the weight of the dried plant, water, a lower alcohol or a mixed solvent thereof, , A mixture of 3-butylene glycol and anhydrous alcohol at an extraction temperature of from room temperature to 100 ° C for about 6 hours to 10 days by an extraction method such as hot water extraction, cold extraction, ultrasonic extraction or reflux cooling extraction, The extract may be further purified by filtration, or the extract may be further concentrated under reduced pressure or lyophilized. The organic solvent includes a nonpolar solvent such as ethyl acetate, chloroform, hexane, and dichloromethane, and the solvent is used at least three times the weight of the herbicide. . When 20 times or more is used, the solvent tends to be consumed more than the extraction amount.

The silk sericin used in the cosmetic composition of the present invention is one of silk proteins. The silk protein consists of fibroin and sericin, and fibroin and sericin are present in the ratio of 75% and 25%, respectively. Fibroin protein is particularly high in glycine and alanine content, while sericin has a completely different amino acid composition than fibroin, and serine occupies more than 1/3 of the total constituent amino acids. Recent studies have shown that silk fibroin has a structure in which the H-chain (350 kDa) and the L-chain (26 kDa) are SS-bound and the glycoprotein P25 (30 kDa) is covalently linked to the two chains , And it was identified as a large protein of 2.3 BG101a having a molar composition of 6: 6: 1, and this structure has a polymeric nature of a block type in which a crystal region and an amorphous region are continuously exchanged and arranged. According to a preferred embodiment of the present invention, the silk protein used is silk sericin, which has the advantage of increasing the elasticity of the scalp and moisturizing the scalp.

Lacquer tree is a deciduous tree that lives in various parts of Korea. Lacquer trees have been used for various fields since ancient times. In the treatment of bronchial asthma, dry lacquer can be used as medicines, insecticides, cough medicine, skin diseases, and wound. It is also known that lacquer has anticancer activity, antioxidant activity, hangover resolution and liver function recovery activity.

According to a preferred embodiment of the present invention, the Rhus verniciflua extract comprises fermenting and aging the Rhus verniciflua var. Sp., Fermenting and drying the aged lacquer tree, obtaining an extract by steaming the dried Rhus verniciflua with an extracting solvent, And filtering the aged extract. ≪ Desc / Clms Page number 7 >

The Rhus verniciflua extract may be extracted using an aqueous solution containing 0.01 to 60% by weight of at least one selected from the group consisting of alcohol, glycerin, alkylene glycol, benzene, chloroform, hexane and acetone or water as an extraction solvent .

In one embodiment, the extract of Rhus verniciflua is obtained by fermenting and aging the Rhus verniciflua var. Sp., Fermenting and drying the aged lacquer tree, obtaining the extract by steaming the dried Rhus verniciflua with an extracting solvent, aging the extract, ≪ / RTI > and filtering the resulting extract.

Fermentation and aging of Rhus verniciflua can be accomplished by soaking in alcohol for 5 to 30 days. It is preferable to use alcohol having a concentration of 1% to 50% in the range, and an alcoholic beverage such as makkolli and soju may be preferably used. Fermentation and aging of Rhus verniciflua occur over 10 to 30 days. If the period is shorter than 1 day, fermentation and aging do not occur sufficiently, and if fermentation is performed for 30 days or more, time is wasted and fermentation may become excessive. If the fermentation and aging are not sufficiently performed for more than one day, the finally obtained Rhus verniciflua extract may cause skin irritation, so that sufficient fermentation and aging process are very important. Preferably, the Rhus verniciflua is fermented and aged for 13 to 17 days. Since the fermentation and aging process is sufficiently performed in this manner, the extract of Rhus verniciflua without skin irritation which can be used for cosmetics can be obtained.

There is no particular limitation on the drying method of the fermented and aged Lacquer tree in the drying method, but it is preferable to leave it for 8 hours or more in the shade to avoid direct sunlight.

In the step of obtaining the extract by steaming the dried Rhus verniciflua with an extraction solvent, water may be used as the extraction solvent, or the component selected from the group consisting of alcohol, glycerin, alkylene glycol, benzene, chloroform, By weight to 60% by weight. The stirring time with the extraction solvent is 1 hour or more, preferably 8 to 10 hours.

The extract obtained by steaming with the extraction solvent is subjected to a step of aging for 1 to 30 days. If the period is shorter than one day, the fermentation will not occur sufficiently, and fermentation for more than 30 days may cause corruption. Preferably aged for 13 to 17 days.

When the aged extract is filtered to separate solid matter, an extract of Rhus verniciflua which can be used as a raw material for cosmetics is produced. When the extract is mixed with oily materials, a cosmetic composition for improving acne, which can be usefully used in various cosmetic formulations .

The Rhus verniciflua extract of the present invention can also be produced by a method other than the method described in detail above. For example, a method of removing toxicity by applying heat to a Rhus verniciflua and extracting the extract from a heat-treated Rhus verniciflua can be used.

The cosmetic composition according to the present invention preferably contains a mixture of keratin, dassia, silk sericin and Rhus verniciflua extract in an amount of 0.1 to 10% by weight based on the total weight of the composition. If the content is less than 0.1% by weight, the efficacy and the effect are insufficient. If the content is more than 10% by weight, there is a problem in formulation stability.

Meanwhile, the cosmetic composition according to the present invention can be formulated by encapsulating a mixture of the keratin, hoseo, silk sericin, and Rhus verniciflua extract, which is a functional substance, into a liposome and stabilizing it. When the above-mentioned mixture is contained in the liposome, the active ingredient contained in the functional material is stabilized to solve problems such as precipitation formation, discoloration, and deterioration during formulation, and the solubility and transdermal absorption rate of the ingredient can be increased. The expected efficacy can be maximized.

In addition, the cosmetic composition of the present invention may contain, in addition to a natural extract, a known substance capable of supplying nutrients to scalp and hair, for example, iron, calcium, manganese, amino acid, pyridoxine hydrochloride, biotin, vitamin B1, vitamin B2, B6, vitamin D and folic acid, polyquaternium-7, tricetylmonium chloride, cetyltrimethylammonium chloride, cetearyl alcohol and the like, preferably the scalp and hair , Panthenol, tocopheryl acetate, or olive oil, which are known to have a moisturizing and protective function of the composition.

The cosmetic composition of the present invention may further comprise, if necessary, a base ingredient which can be compounded into a general external scalp and hair preparation. Specifically, it may include a solubilizer, a thickener, a pH adjuster, an antiseptic, an antioxidant, a sequestering agent, a bactericide, a preservative, an anti-inflammatory agent, an antimicrobial agent, a solvent, a colorant or a flavoring agent.

Solubilizing agents that may be included in the cosmetic composition of the present invention may be isopropyl myristate, polyethylene glycol, triglycerides of medium chain fatty acids, hydrocarbons, glycols and the like. Further, the thickening agent may be a water-soluble polymer compound such as methyl cellulose, hydroxyethyl cellulose, carrageenan, carboxymethyl cellulose, hydroxymethyl cellulose and the like. The pH adjuster may specifically include citric acid, sodium hydroxide, triethanolamine, sodium citrate, phosphoric acid, sodium phosphate, lactic acid, and the like.

The preservative may be benzoic acid, a mixture of paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, DMDM, and the like. Specific examples of the antioxidant include dibutylhydroxytoluene, ascorbic acid, and the like. Examples of the sequestering agent include disodium ethylenediaminetetraacetate, tetranodium ethylenediaminetetraacetate, and the like. Specifically, the disinfectant may be chlorhexidine gluconate, quaternary ammonium salt, pyrrothonol amine, zinc pyrithione suspension, urethropropinyl Butylcarbamate, salicylic acid, and the like.

Examples of preservatives include urea, chlorohexidine digluconate, phenoxyethanol, sodium benzoate, sorbic acid, methylparaben, and the like.

Examples of the anti-inflammatory component include monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, stearyl glycyrrhizinate, chamomile, alpha bisabolol, allantoin, and mixtures thereof. Antimicrobial (antimicrobial) But are not limited to, ethanol, chlorhexidine, chlorhexidine gluconate, pylontonol amine, ketoconazole, arnica extract, urethropropyl butylcarbamate, benzalkonium chloride, benzenethonium chloride, benzoic acid and its salts, benzyl alcohol, lavender, rosemary, salicylic acid, trichlorocarbane, A picrichone suspension, a mixture thereof and the like can be used. In addition, the coloring agent and the flavoring agent may be the conventional agents used in the scalp and hair formulations.

The cosmetic composition of the present invention preferably has a pH in the range of 7.5 to 9.0, and more preferably has a pH of about 8.5. Such pH can be adjusted by adjusting the concentration and the content of the constituents contained in the composition, for example, a reducing agent, an alkaline agent, a pH adjusting agent, and the like.

A first layer comprising the functional material of the cosmetic composition according to the present invention and an aqueous phase; A second layer of silica silicate formed on the surface of the first layer; And a third layer of film forming agent formed on the surface of the second layer.

The water layer of the first layer according to an embodiment of the present invention may contain 0.1 to 10% by weight of polyol and water.

The functional material according to the present invention contained in the first layer can be stabilized and encapsulated in a single closed compartment, and can be formulated together with the aqueous phase in the liposome, so that the active ingredient of the functional material is stabilized, Solubility and transdermal absorption rate of the component can be increased, and the effect expected from the functional substance can be maximally expressed.

The encapsulated functional material prepared according to an embodiment of the present invention may have an average particle size of 1 to 500 nm, preferably 10 to 300 nm.

According to a preferred embodiment of the present invention, the liposome of the present invention has a particle size of 3,000 to 10,000 nm, preferably 5,000 to 8,000 nm. When the particle size of the liposome is less than 3,000 nm, the three-layered multi-layered liposome can not be obtained, the amount of the functional material to be encapsulated in the first layer is very small, In the case of exceeding 10,000 nm, the bonding relation between each layer is weakened, so that the layer separation phenomenon occurs due to the functional material, so that the stability of the formulation is improved. There is a problem.

The preparation of the liposome according to an embodiment of the present invention may be performed by various methods known in the art. For example, a mixture containing the components may be prepared by applying a Henschel mixer.

The cosmetic composition of the present invention is not particularly limited in formulation, but may be formulated into hair tonic, hair nutritional lotion, scarf treatment, hair treatment, hair rinse, hair shampoo, hair lotion or scalp hair- .

In addition, in the respective formulations, the ingredients other than the above-mentioned essential ingredients can be suitably selected and blended by those skilled in the art depending on the kind of the external preparation, the purpose of use, and the like.

The cosmetic composition according to the present invention has an average size of particles of 3,000 to 10,000 nm and is stable in size and stable in structure. When the composition is rubbed at a constant pressure, the functional ingredient is not destroyed, It is possible to provide a synergistic effect on the scalp improvement and hair protecting effect of the active ingredient contained in each functional substance immediately after hair application.

Since the cosmetic composition according to the present invention is produced in the form of a multilayer liposome, the hair setting ability and the sustaining ability of the functional material of the composition are maintained for a long time, and also the stickiness is small and the spreadability is excellent, So that it is possible to easily produce a desired hair style.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic representation of a liposome cosmetic composition according to an embodiment of the present invention. FIG.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. However, the following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited to the following examples. The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

[ Example  And Comparative Example ]

Each of the compositions for improving hair styling comprising the composition and the contents shown in Table 1 below is prepared, and the content of the composition is% by weight.

[ Test Example  One]

Table 1 shows the results of the determination of powdering, hair setting power, aging stability, impact strength, liquefaction property, and dusting of the hair styling improving compositions prepared in the above Table 1 based on the following methods and criteria.

Measurement method and judgment standard

(A) Powdering: 50 (300 mu m) was passed through.

A: Pass more than 95%

B: Less than 90 to less than 95%

C: Less than 85 to less than 90%

D: Less than 80 to less than 85%

E: Less than 75 to less than 80%

F: Pass less than 75%

(B) Stability over time: A method of checking after standing at 40 ° C for 7 days was used.

○: No change in appearance

?: Slight color change

X: Separation phenomenon (the water layer is located at the bottom)

(C) Impact strength: The content was measured by dropping at a height of 50 cm by filling 20 g of sample into a 40 ml sample bottle.

○: No change in appearance

Δ: Appearance of some separation phenomenon

X: Separation phenomenon (the layer of the water layer is in the lower part)

(D) Liquid property: Measured using a method of rubbing the hand with 1 g of the content.

○: Rapid liquefaction

Δ: Slowly liquefied

X: Liquefaction is slow and remains whitish

(E) Hair setting power

○: Good

△: Normal

Poor: Poor

(F) Flour: Judged by the naked eye.

A: Almost none

B: A little

C: Normal

D: A little too much

E: Very high

As can be seen from the results of Table 2, even in the case of the liposomes of Comparative Examples 1 to 6, in particular, even if the composition components of the present invention are all included, the composition of Comparative Example 1, One was found to be inferior in liquefaction property.

In Comparative Examples 2 to 6, even if they were prepared by mixing some of the composition components of the present invention and replacing some similar composition components and mixing them in the same composition ratio of the present invention, powder properties were also difficult, Was difficult.

In addition, in the case of all the liposomes of the comparative examples, it was confirmed that the powder was not uniformly formed and the liquefaction property was not easy, and it was confirmed that cloudiness remained when using the liposome. On the other hand, in the case of the liposomes of the examples, it was confirmed that the average size of the particles was kept constant from 5,000 to 8,000 nm and the stability of the structure was excellent.

In addition, it was confirmed from the results of Comparative Example 2 and Example 3 that the combination of the modified starch surprisingly further stabilizes the functional component so that the functional component is not separated, By protecting the material and stabilizing it in the form of particles, when it is rubbed at a certain pressure, the active ingredient contained in each functional material can be absorbed into the scalp by dissolving it in a liquid form, and the hair can be immediately absorbed into the scalp, thereby maximizing the efficacy of the active ingredient, Was given.

[ Test Example  2]

The setting power, duration, and overall satisfaction of the hair styling improving agent prepared in Table 1 were evaluated by 20 expert panels. Satisfaction level of each item was evaluated on the scale of 1, 3, 5, 7, and 9 points and then it was added to the average [9 points: very satisfied, 7 points: satisfied, 5 points: normal, 3 points: dissatisfied, 1 point : very unsatisfied].

As can be seen from the results of Table 3 above, it was confirmed that the hair styling improving agents of Examples 1 to 4 exhibited excellent hair setting power, durability and overall satisfaction as compared with Comparative Examples 1 to 6.

Claims (8)

1 to 15% by weight of silica silicate; 0.01 to 20% by weight of at least one film former selected from vinyl pyrrolidone / vinyl acetate copolymer, octyl acrylamide / acrylate / butylaminoethyl methacrylate copolymer, and acrylate / octylacrylamide copolymer; And 1 to 15% by weight of a functional material, the balance being a solvent comprising water. The method according to claim 1,
Wherein the composition further comprises 0.1 to 10 parts by weight of modified starch per 100 parts by weight of the total composition. The method according to claim 1,
Wherein the solvent comprises at least one polyol selected from glycerin, sorbitol, trehalose, maltitol and sodium hyaruronate. The method according to claim 1,
Wherein the functional material is a mixture of keratin, dassia, silk sericin, and Rhus verniciflua extract. 5. The compound according to any one of claims 1 to 4,
The liposomes are multilayer liposomes,
Said multilayer liposome comprising: a first layer comprising a functional material and a water-receiving portion;
A second layer of silica silicate formed on the surface of the first layer; And
And a third layer of film forming agent formed on the surface of the second layer. 6. The method of claim 5,
Wherein the water layer portion of the first layer comprises 0.1 to 20 wt% of a polyol. 6. The method of claim 5,
Wherein the second layer further comprises modified starch. 6. The method of claim 5,
Wherein the particle size of the liposome is from 3,000 to 10,000 nm.

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