KR20110047374A - Cosmetic composition for improving the male skin - Google Patents

Abstract

PURPOSE: A cosmetic composition containing Cryptomeria japonica extract and Bambusoidea extract is provided to suppress inflammation-mediated factor expression and to relieve skin irritation and inflammation due to acne. CONSTITUTION: A cosmetic composition for improving man's skin condition contains 0.001-20 weight% of Cryptomeria japonica extract and Bambusoidea extract as an active ingredient. The cosmetic composition is manufactured in the form of emulsion, suspension, microemulsion, microcapsule, microgranule or ionic(liposome) and non-ionic vesicle dispersion by an oil phase to a solution, gel, solid, kneaded anhydrous product, and aqueous phase.

Description

Cosmetic composition for improving male skin {Cosmetic composition for improving the male skin}

The present invention relates to a cosmetic composition for improving male skin, and more particularly, containing cedar extract and bamboo extract, showing an excellent effect on skin moisturizing and simultaneously inhibiting the expression of inflammatory mediators to prevent skin irritation and inflammation caused by acne. It relates to a cosmetic composition for improving male skin showing a relieving effect.

The skin protects the body from external physical and chemical stimuli and is divided into three layers: epidermis, dermis and subcutaneous fat tissue. In particular, the skin contains about 65-70% of the water that the human body has, which carries various biologically active substances necessary for the human body and helps keep the skin moist. In addition, the skin plays an important role in controlling the evaporation of this moisture into the body. The epidermis is divided into the stratum corneum, granule layer, play layer and basal layer from the outside. The stratum corneum of the epidermis contains about 10-20% of moisture and is located at the outermost part of the human body, forming a natural protective film made of sebum from the sebaceous glands and sweat from the glands, preventing evaporation of moisture from outside the body. Blocks material infiltration. The cells constituting the stratum corneum have a high concentration of natural moisturizing factor (NMF), which is a water-soluble ingredient, which helps the skin to show flexibility and maintain proper moisture. However, due to various factors such as artificial temperature control of cooling / heating according to the change of environment or living pattern, skin stress due to various stresses and environmental pollution, frequent face wash due to makeup habits and natural skin aging due to age increase Due to the decrease in moisture in the stratum corneum, the skin is dried, the surface is rough, and the skin loses its shine and dull appearance occurs, so the need for a skin moisturizer is increasing.

In addition, men's skin increases sebaceous glands due to the strong secretion of the male hormone, androgen (androgen), which is the biggest difference from women's skin, and secreted sebum is 1.5 ~ 2 times more than women in most face areas (William J Cunliffe: Acne, Martin Dunitz Ltd, 140, 1989) When the above-mentioned general humectants and closed moisturizers are used, sebum secreted from sebaceous glands is blocked in the pores and causes inflammation such as acne. This is limited.

Acne is a chronic sebaceous inflammatory disease caused by the retention of hyperkeratosis in the pores caused by sebum, which is mainly caused by excessive secretion of sebum, infection of the pores, narrowing of the hair follicles, stenosis, and the growth of acne bacteria. , Inflammatory reactions, etc. can be explained according to the degree of development of acne symptoms, and various mechanisms may work in combination.

Thus, the cosmetic industry has been attempted to alleviate the immune response by the control of inflammatory mediators, and to alleviate skin irritation through skin barrier strengthening, skin protection. Specific examples include a bradykinin antagonist (see USP 5,849,312) for controlling inflammatory mediators and adverse reactions of sensitive skin, and an example of applying a cytokine TNF-α inhibitor as a sensitive skin preparation (US Patent Application Publication). 5,851,556).

To date, chemicals that can be used to alleviate irritation and inflammation such as erythema and edema are nonsteroidal substances such as flufenamic acid, ibuprofen, benzydamine, and indomethacin. Steroidal substances include prednisolone and dexamethasone (Kim Chang-jong, Pathophysiology, Hallym Co., p61-69, 1988), and other allantoin, azulene, ε-aminokiproic acid, Hydrocortisone, licorice acid, and derivatives thereof (β-glycileic acid, glycylinic acid derivatives) are also known to be effective in anti-inflammatory (Ministry of Gwangjeongjeong, New Cosmetics, Namsan Sugar, p162, 1993).

However, indomethacin, which is used as an anti-inflammatory agent, cannot be used in cosmetics, and hydrocortisone has a limited amount of use. Licorice acid and its derivatives are difficult to stabilize or have poor solubility. The anti-inflammatory agents known to date, such as difficulties, have problems in terms of skin safety and stability in formulating cosmetics, and their use is limited.

Therefore, the present inventors have studied to find a substance containing a large amount of moisture in the stratum corneum of the male skin and reducing the evaporation of moisture while improving the acne, cedar extract and bamboo extract has excellent water retention ability to evaporate moisture of the male skin. The present invention has been found to relieve skin irritation and inflammation caused by acne by reducing expression of inflammatory mediators.

Accordingly, it is an object of the present invention to provide a cosmetic composition for improving male skin having skin moisturizing power and acne improving effect.

In order to achieve the above object, the present invention provides a cosmetic composition for improving male skin containing cedar extract and bamboo extract as an active ingredient.

The cosmetic composition provided by the present invention has excellent moisture retention by containing cedar extract and bamboo extract, which contains a large amount of water and reduces the evaporation of moisture of the male skin and at the same time inhibits the expression of inflammatory mediators, thereby stimulating the skin due to acne. And it can alleviate inflammation, and because it is safe for the human body using natural plant extracts can be used to improve the skin of men.

The present invention provides a cosmetic composition for improving male skin containing Cedar (Cryptomeria japonica) extract and Bamboo (Bambusoidea) extract as an active ingredient.

Hereinafter, the present invention will be described in more detail.

Cedar (Cryptomeria japonica) used as an active ingredient in the present invention is an evergreen arboreal tree of larch and is cold-resistant and can be grown only in the southern region, and its origin is Japan, but it is planted a lot in windbreak forests in Jeju, etc. It grows up to 4m and leaves are 0.5 ~ 1cm in needle shape. Cedar is rich in phytoncide, which is widely known for its antimicrobial effects. It is a substance released by plants to resist pests, germs and bacteria. It has been widely used for allergic skin diseases such as swelling and atopic dermatitis.

Bamboo (Bambusoidea) used as an active ingredient in the present invention is an evergreen perennial plant belonging to the rice plant and bamboo subfamily, but it is widely distributed in the world, but mainly grows in tropical regions, especially in the monsoon region of Asia, and in South Korea and South Korea It is distributed. In the case of tall royal genus, it can grow up to 30m in height and 30cm in diameter. Bamboo is rich in moisture, protein, Tyrosine, Arginine, Histidine, Leucine, Linoleie acid and Linolenic acid. It is widely known for its antibacterial action.

Cedar extract and bamboo extract of the present invention can be prepared by a conventional extraction method in the art, the method is not particularly limited.

The cosmetic composition according to the present invention contains the cedar extract and the bamboo extract in an amount of 0.001 to 20% by weight, respectively, based on the total weight of the composition. If the content is less than 0.001% by weight, the skin moisturizing and acne-improving effect by the extract can not be largely obtained, and if it exceeds 20% by weight, the increase in effect is not large compared to the increase in content, which is rather inefficient.

The cosmetic composition according to the present invention contains the cedar extract and the bamboo extract in a mixing ratio of 1: 0.1 to 1:10. If it is less than 1: 0.1, it is difficult to obtain an effective moisturizing effect of bamboo, and if it is more than 1:10, it is difficult to obtain an effective antibacterial effect of cedar, so it is necessary to include two active ingredients in the above mixing ratio to obtain proper skin moisturizing and antibacterial effect. Can be.

Cosmetic compositions according to the invention may be formulated containing a cosmetically or dermatologically acceptable medium or base. It is any formulation suitable for skin, for example emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) and nonionics obtained by dispersing an oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases. It may be provided in the form of a vesicle dispersant in the form, or in the form of a skin, lotion, cream, pack, gel, makeup base, foundation, powder, ointment, spray or concealed stick. These compositions may be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition according to the present invention is a fatty substance, an organic solvent, a dissolving agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, an ionic or nonionic. Such as type emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredients commonly used in cosmetics It may contain adjuvants conventionally used in the field of cosmetics or dermatology. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological fields.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not necessarily limited to these examples.

Preparation Example Preparation of Cedar Extract and Bamboo Extract

Each cedar leaf and bamboo were dried and crushed by 100 g of dry weight and double vacuum packed into an ultra high pressure bag, followed by ultra high pressure extraction at 1000 at 25 ° C. for 8 hours. Subsequently, the filtrate was filtered through 80 mesh and centrifuged at 15 ° C. at 8000 rpm for 30 minutes, and then filtered again to remove debris, which was diluted with a ratio of glycerin and distilled water 7: 1 to obtain a cedar extract and a bamboo extract.

EXAMPLE 1 AND COMPARATIVE EXAMPLES 1-3

Table 1 and Example 1 containing the cedar extract and bamboo extract (preparation example) and Comparative Examples 1-2 containing the cedar extract or bamboo extract, respectively, Comparative Example not containing both cedar extract and bamboo extract 3 was prepared.

division Raw material name Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Comparative Example 3
(weight%) Paid Part Polysorbate 60 1.0 1.0 1.0 1.0 Glyceryl stearate 0.5 0.5 0.5 0.5 Fiji-100 Stearate 1.0 1.0 1.0 1.0 Meadowfoam seed oil 3.0 3.0 3.0 3.0 Cyclomethicone 2.0 2.0 2.0 2.0 Dimethicone 3.0 3.0 3.0 3.0 Behenyl alcohol 1.0 1.0 1.0 1.0 Cetearyl Alcohol 1.0 1.0 1.0 1.0 Cetylethylhexanoate 10.0 10.0 10.0 10.0 antiseptic Quantity Quantity Quantity Quantity Spices Quantity Quantity Quantity Quantity Water Part Purified water To 100 To 100 To 100 To 100 Disodium ID 0.05 0.05 0.05 0.05 glycerin 10.0 10.0 10.0 10 Other thickeners, neutralizers Quantity Quantity Quantity Quantity Cedar extract 1.0 1.0 - - Bamboo extract 1.0 - 1.0 -

<Production method of Example 1 and Comparative Examples 1 to 3>

1) The components of the oil phase were heated and dissolved at 70 ° C. in a separate container and dispersed using a homogenizer.

2) The components of the water phase were heated and dissolved at 70 ° C. in a separate container.

3) The oil phase part mixture of 1) was slowly added to the water phase mixture of 2) and emulsified at 70 ° C.

4) The emulsified product of 3) was filled into an airtight container and cooled to room temperature using a cooler to prepare a cosmetic composition of an O / W formulation.

Test Example 1 Human Test on Skin Moisturizing

1. Moisturizing effect experiment

40 adult males who complained of dryness or dry skin were coated with the cosmetic composition of Example 1 and Comparative Examples 1 to 3 twice daily for 4 weeks on the inner side of Habak. Trans Epidermal Water Loss (TEWL) was measured in the following manner at constant temperature and humidity conditions (24 ° C., 40% relative humidity) at two and four weeks after application. The amount of skin moisture before application was 100, and the amount of water evaporated over time was subtracted to calculate the amount of skin moisture 2 weeks and 4 weeks after application. The results are shown in FIG.

<TEWL measurement method>

The amount of water evaporated from the skin is calculated according to the area and time, and the amount of water evaporated is read and quantified by the temperature and moisture electronic sensors to measure the skin's moisturizing power.

1. Environmental conditions: The temperature and humidity are kept constant, leaving only a minimum of personnel (as far as possible).

2. Place the TEWL probe on the subject's measurement site.

3. Do not apply excessive force to the measuring area (not leaving any traces on the skin) and place the probe at an angle of 90 degrees to the ground.

4. Measure the value that the skin's TEWL level becomes constant over time (usually 1-3 minutes).

5. Hold the probe handle as far as possible to avoid passing the temperature of the operator.

6. Calculate the amount of water evaporated per hour per area (g / m ² / h).

As shown in the results of Figure 1, in the case of Example 1 and Comparative Examples 1 to 2 containing the cedar extract and bamboo extract, compared to Comparative Example 3 does not contain both the cedar extract and bamboo extract over time As a result, it was found that the TEWL change value (the amount of evaporation of water) tends to decrease. In particular, Example 1 containing the cedar extract and bamboo extract at the same time was confirmed to show an excellent skin moisturizing effect than Comparative Examples 1 to 2 each containing an active ingredient.

2. Moisturizing Sustainability Experiment

In order to determine the moisturizing sustainability in one application, after applying Example 1, the skin moisture content was measured using a corneometer for 6 hours according to the following method, and the results are shown in FIG. 2.

<Measuring Water Meter>

Moisture is measured by measuring the amount of moisture by measuring the amount of moisture in the skin's epidermis using a sensor and quantifying it.

1. Place the probe of the corneometer on the area of skin to be measured.

2. When the probe is pressed on the skin, the electrical capacitance of the skin is quantified through the sensor and displayed on the screen.

3. Repeat the measurement with different measuring area. After measuring once, wipe the sensor with a tissue such as Kimwipe and measure again.

As shown in the results of FIG. 2, in the untreated group, the skin moisture content decreases with time, whereas the skin moisture content is remarkably increased when Example 1, which is a formulation containing both cedar extract and bamboo extract, is applied. It was confirmed that the persistence of skin moisturizing was very excellent.

Meanwhile, at the end of the test, the test subjects were asked to fill out a questionnaire, and mechanical evaluation and subjective efficacy evaluation were also performed. The results are shown in Table 2 below.

Skin Dryness Improvement Effects Survey Applicator Respondents Very good Good usually Inadequate Example 1 20 15 5 0 Comparative Example 1 10 13 12 5 Comparative Example 2 7 10 18 5 Comparative Example 3 One 2 15 22

Looking at the results of Table 2, it was found that the satisfaction of the moisturizing effect of the person who applied Example 1 simultaneously containing cedar extract and bamboo extract was significantly high.

Test Example 2 Confirmation of PGE2 Inhibitory Effect of Cedar Extract and Bamboo Extract by Stimulating Acne Bacteria Extract

Test cells, keratinocytes (cell name: HaCaT, purchased from Dr. NE Fusenig, Deutsches Krebsforschungszentrum, Heidelberg, Germany) were added 10% fetal bovine serum (Ftal bovine sereum, FBS, purchased from Gibco, USA) and 1% penicillin Approximately 3 × 10 ⁵ cell counts / well in 24 well plates using Dulbecco's Modified Eagle Medium (Lonza, USA) medium containing Penicillin-Streptomycin (Gibco, USA) After dispensing at a density of 37 ° C., 5% CO ₂ Incubated for 24 hours under conditions. Propionibacterium by the P. acne incubated in an anaerobic environment for the production acnes, or less P. acne) extract was centrifuged at 5,000rpm to separate the culture medium and acne bacteria. 1 ml of PBS was added to the isolated acne bacteria, sonicated for 30 minutes, and the cells were crushed and used for the following test. The untreated group was used as a control, and the experimental group was treated with cedar extract with acne bacteria extract by concentration gradient, and the other experimental group was treated with acne bacteria extract and cedar extract and bamboo extract treated with concentration gradient 1% together. Incubate for 48 hours. The culture medium of each group was collected to perform a PGE2 ELISA, the results are shown in Table 3 and FIG.

Cedar Extract Concentration (%) PGE2 concentration (nM) Average PGE2 Concentration Standard deviation rate % control No treatment 0 0.478 0.501 0.523 0.501 0.023 One P. acne extract + cedar extract 0 2.954 3.056 2.846 2.952 0.105 5.896138482 0.1 1.005 1.125 1.354 1.161 0.177 2.319573901 0.5 0.545 0.789 0.801 0.712 0.144 1.421438083 One 0.654 0.536 0.58 0.590 0.060 1.178428762 P. acne extract + cedar extract + bamboo extract 1% 0 2.954 3.154 1.513 2.540 0.895 5.073901465 0.1 0.978 0.965 1.356 1.100 0.222 2.196404794 0.5 0.652 0.64 0.786 0.693 0.081 1.383488682 One 0.513 0.526 0.503 0.514 0.012 1.026631158

As can be seen from the results of Table 3 and Figure 3, the group treated with acne bacteria extract alone increased the inflammatory factor (PGE2) by about 5.9 times compared to the untreated group, but the expression of inflammatory factors in a concentration-dependent manner when the cedar extract was treated This was suppressed. In particular, when treated together with cedar extract and bamboo extract was confirmed that the inflammation inhibitory effect is greater, when treated with cedar extract 1% and bamboo extract 1% together with untreated group not treated with acne bacteria extract Similar levels could reduce the expression of inflammatory factors.

Therefore, the composition containing the cedar extract and bamboo extract of the present invention as an active ingredient was confirmed that the effect of suppressing inflammation due to acne is excellent.

Test Example 3 Sensory Evaluation of Acne Improvement Effect

For 20 men with 19 to 26 years of age with acne, the cosmetic composition of Example 1 and Comparative Examples 1 to 3 was used in the same manner as the general lotion for 4 weeks, and according to the opinion of the user, the degree of skin improvement Was determined according to the following evaluation criteria. The results are shown in Table 4 below.

<Evaluation Criteria>

+++: Very good improvement.

++: Significant improvement.

+: A slight improvement.

±: No improvement but no deterioration.

-: No improvement, rather worse.

Test substance term 1 week 2 weeks 3 weeks 4 Weeks Example 1 ++ +++ +++ +++ Comparative Example 1 + + ++ ++ Comparative Example 2 ± + + ++ Comparative Example 3 ± ± ± +

As can be seen in Table 4, Example 1 containing both cedar extract and bamboo extract compared to Comparative Examples 1 to 3 containing or not containing both cedar extract and bamboo extract shows a rapid and excellent acne improvement effect It was.

1 is a graph showing the TEWL measurement results measured at 2 and 4 weeks after application, before application of Example 1 and Comparative Examples 1 to 3. FIG.

Figure 2 is a graph showing the results of measuring the moisture content of the skin for 6 hours after one application in order to determine the moisturizing sustainability of Example 1 and the untreated group.

Figure 3 is a graph showing the inflammation inhibitory effect by acne of cedar extract and bamboo extract of the present invention.

Claims (5)

Cosmetic composition for improving male skin containing cedar (Cryptomeria japonica) extract and bamboo (Bambusoidea) extract as an active ingredient. The cosmetic composition for improving male skin according to claim 1, wherein the cedar extract and the bamboo extract are contained in a mixing ratio of 1: 0.1 to 1:10. The cosmetic composition for improving male skin according to claim 1, wherein the cedar extract and the bamboo extract are contained in an amount of 0.001 to 20% by weight, respectively, based on the total weight of the composition. The cosmetic composition for improving male skin according to any one of claims 1 to 3, wherein the composition is for improving skin moisturizing ability. The cosmetic composition for improving male skin according to any one of claims 1 to 3, wherein the composition is for improving acne.

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