KR20120009147A - Composition of skin external application for moisturizing the skin containing Oldenlandia diffusa extracts - Google Patents

Abstract

PURPOSE: An external use skin composition containing Oldenlandia diffusa extract is provided to treat skin dryness and to ensure skin moisturizing. CONSTITUTION: An external use skin composition for skin moisturizing contains 0.0001-50 wt% of Oldenlandia diffusa extract as an active ingredient. The external skin composition is manufactured in the form of a solution, gel, solid, kneaded anhydrous product, suspension, microemulsion, microcapsule, microgranule, or ion type(liposome) and non-ion type vesicle dispersion agent, cream, skin, lotion, powder, ointment, spray, or pack.

Description

Composition for skin external application for moisturizing the skin containing Oldenlandia diffusa extracts}

The present invention relates to an external composition for moisturizing skin which can improve skin dryness, and more particularly, to an external composition for skin moisturizing, containing white bisulfate extract having excellent moisture support and retention ability as an active ingredient. It is about.

The skin is divided into three layers of epidermis, dermis and subcutaneous fat tissue in order from the outside and functions to protect the human body from physical or chemical stimuli from the external environment. In particular, the skin carries about 65-70% of the moisture that the human body has, that is, it carries various biologically active substances necessary for the human body, and plays an important role in controlling the evaporation of moisture to the body to help the skin stay soft and moist. Do it. In addition, the epidermis is separated from the outside in the order of the stratum corneum, granule layer, polar layer and basal layer, the cells of the stratum corneum act like a brick and the intercellular lipids between the stratum corneum act as a mortar to form the skin barrier ( J. Invest.Drmatol. 80 (Suppl.), 44-49, 1983). The stratum corneum of the epidermis contains about 10 to 20% of water and is present at the outermost part of the human body to suppress evaporation of moisture from the outside while preventing excessive infiltration of substances from the outside. The surface of these stratum corneum is covered with a thin, natural protective film made of sebum from the sebaceous glands and sweat from the glands to prevent evaporation of moisture. In other words, you can think of it as a form in which a sponge containing a water (stratum corneum) is wrapped in a plastic wrap (natural protective film) which does not pass water. The cells constituting the stratum corneum have high concentrations of natural moisturizing factors (NMF), which are water-soluble ingredients, which help the skin to show flexibility and maintain proper moisture. The substance is not only water soluble, but effectively binds with moisture and inhibits the drying of moisture from the skin (J. Invest. Dermatol. 54, 24-31, 1970). However, artificial temperature control of cooling / heating according to changes in environment or life patterns, skin stress caused by various stresses and environmental pollution from social life, frequent face wash due to makeup habits, and natural skin aging due to age increase Due to various causes of the moisture in the stratum corneum decreases, the skin is dried, the surface is rough, and the skin loses shine and dull appearance occurs, the need for a skin moisturizer is increasing.

Conventionally, the most widely used method is to use a humectant, which has a property of absorbing water as a moisturizer, or an occlusive moisturizer that prevents evaporation of water, thereby increasing water retention in the stratum corneum. to be. Most of the humectants are polyols, and there are materials such as glycerin, propylene glycol, 1,3-butylene glycol, and polyethylene glycol. However, they have a disadvantage in that they are very sticky or damp due to the inherent viscosity and physical properties of the polyol when applied to the skin. In addition, as a closed moisturizer, lipid components such as ceramide, essential fatty acids and lipid complexes were used (J. Invest. Dermatol. There is a disadvantage that inhibits and there are disadvantages inadequate for preparing a product on a transparent gel. Formulations containing lamellar liquid crystals, which have been studied until recently, are known to have excellent moisture moisturizing properties with advantages similar to the skin keratin structure, but are problematic in that they can be universally used only in specific compositions of raw materials.

Thus, the present inventors have studied to find a natural product with excellent skin moisturizing effect, found that baekrye sageweed has excellent water holding and holding ability and completed the present invention.

Therefore, it is an object of the present invention to provide a skin external preparation composition excellent in skin moisturizing power by containing baekhwasachocho extract as an active ingredient.

In order to achieve the above object, the present invention provides a moisturizing composition for skin external use containing baekhwasachocho extract as an active ingredient.

The external preparation composition for skin provided by the present invention contains baekhwasachocho extract with high moisture support and high retention, and is excellent in skin moisturizing power and very safe for human body using natural products. Therefore, the present invention can provide a skin external preparation composition which is excellent in moisturizing effect and effective in improving skin dryness.

The present invention provides an external composition for moisturizing skin containing the extract of Oledenlandia diffusa as an active ingredient.

Hereinafter, the present invention will be described in more detail.

Baekhwasasulcho used as an active ingredient in the present invention is one of the herbal medicines that have been widely known and used as folk medicine as well as oriental medicine. Oldenlandia Diffusa Willd is a Rubiaceae plant that grows in the lush, shady forests of southern China, Southeast Asia and Jeju Island. Ingredients included in Bacteria (Betulin), Betulinic acid, Ursolic acid, Oleanolic acid, Stigmasterol, Beta-Sitosterol , Β-Glycyrretinic acid, β-Gumalic acid (ρ-Coumaric acid), Glucoside (Glucoside), Hentriacontane, etc. It is known to represent.

Baeksasasulcho extract of the present invention can be prepared according to methods known in the art, the method is not particularly limited. Specific examples include water, lower alcohol (methanol, ethanol), a mixture of water and lower alcohol, acetone, 1,3-butylene glycol, Polar solvents such as normal propanol, isopropanol and normal butanol and mixed solvents thereof are added in 5 to 20 times by volume, followed by immersion extraction and filtration. The filtrate is concentrated under reduced pressure. Water is added to the concentrated solution to disperse the same, and then a low amount of an organic solvent such as ethyl acetate, chloroform and diethyl ether is added to the dispersion and shaken. The organic layer is separated and concentrated under reduced pressure to obtain an excellent extract. Extraction method is 12 to 96 hours for cold acupuncture and percolation, or anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, ethyl acetate, or diethyl ether as a solvent and left for 3 to 20 days at room temperature of 4 to 25 ° C. The active ingredient can also be extracted by aging. In the case of a warm needle, it is different depending on the type and temperature of the solvent and the like to be used, but it is preferable to perform about 5 to 24 hours at a temperature close to the reflux temperature of the solvent.

Baekhwasasajeol extract prepared as described above exhibits a strong skin moisturizing effect, harmless and safe to the human body can be provided as a skin external preparation.

The external preparation composition for skin of the present invention contains baekhwasachocho extract in an amount of 0.0001 to 50% by weight, more preferably 0.01 to 20% by weight based on the total weight of the composition. This is because less than 0.0001% by weight of the skin moisturizing effect is insignificant, and if it exceeds 50% by weight, the increase in effect is not large compared to the increase in content.

The external preparation composition for skin according to the present invention may be formulated containing a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing an oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases and It may be provided in the form of a nonionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray, pack, or cone stick. It may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions may be prepared according to conventional methods in the art.

In addition, the composition for external application for skin according to the present invention is a fatty substance, an organic solvent, a dissolving agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, an ionic type. Or nonionic emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other commonly used in cosmetics It may contain adjuvants conventionally used in the cosmetic or dermatological fields, such as ingredients. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to test examples and examples. However, these test examples and examples are provided only for the purpose of illustration in order to help the understanding of the present invention is not limited to the scope and scope of the present invention.

Preparation Example 1 Preparation of Pear Blossom

Wash white chlorosis with purified water and dry it, and then, 100 g of crushed white sultry powder was put in 1 L of ethanol, extracted by boiling in an extractor equipped with a cooling condenser for 12 hours, filtered through a 300 mesh filter cloth, and the filtrate was filtered at 4-15 ° C. for 7 days. After standing and aged, the filter was filtered through Whatman No. 2 filter paper to remove insoluble matters. The filtrate obtained was concentrated under reduced pressure to 60 ° C. using a distillation apparatus equipped with a cooling condenser. The resultant was dispersed in 50 ml of water, extracted again with 300 ml of ethyl acetate, and then the organic layer was concentrated and freeze-dried to obtain a white chlorosis extract having a dry weight of 19.4 g.

Test Example 1 Evaluation of Skin Moisturizing Effect

In order to examine the skin moisturizing effect of Pear vulgaris extract, 14 healthy males and females in their 20s and 30s (7 males and 7 females) were applied to 3 sites of 3 × 3㎝ square on the inner side of the lower chest.

The test substance was diluted with 1% concentration of Baksasachocho extract of Preparation Example 1, and 5% of glycerin was used as a positive control. The skin moisture content of the test substance at the beginning, after 2 days, after 7 days, and after 11 days was measured with a coronometer (Corneometer CM825 (C + K GmbH, Germany)) according to the following method, and the results are shown in Table 1 below. It was.

<Measurement of Koniometer>

Principle: The amount of moisture present in the skin's epidermis is measured by measuring the amount of ions in the water using an electrical measurement method.

1. Place the probe of the Koniometer on the skin area to be measured.

2. When the probe is pressed on the skin, the electrical conductivity of the skin is quantified through the sensor and displayed on the screen.

3. Repeat the measurement three times at each site to get the average value.

Electrical Conductivity (Mean ± Standard Deviation, ACU) (**: p <0.01 compared to no treatment group) division Early 2 days later 7 days later 11 days later White flower iris extract 25.21 ± 5.75 30.46 ± 5.95 31.63 ± 5.2 30.71 ± 3.68 glycerin 26.08 ± 4.17 32.04 ± 3.74 33.25 ± 3.07 33.25 ± 3.46 Untreated group 24.75 ± 4.98 25.29 ± 5.5 23.29 ± 4.57 24.5 ± 4.62

As can be seen in Table 1 above, when the baekhwasajeol extract according to the present invention is applied to the skin, the skin moisture content showed a statistically significant trend (paired T-test, p <0.01) and even after 11 days of application The amount of moisture was maintained. Therefore, the composition containing baekryeoksacho according to the present invention is excellent in moisturizing power by effectively preserving the moisture of the skin after application.

[Examples 1 and 2 and Comparative Example 1]

According to the composition shown in Table 2, Examples 1-2 and Comparative Example 1 were prepared. The following compositions are in O / W formulation and are in weight percent.

division Raw material name Example 1 Example 2 Comparative Example 1 Paid
ingredient Stearic acid 1.0 1.0 1.0 Cetearyl Alcohol 0.2 0.2 0.2 Hydrogenated Oil 0.7 0.7 0.7 Chin type glyceryl stearate 0.5 0.5 0.5 Hydrogenated Lecithin / C12-16 Alcohol / Palmetic Acid 1.0 1.0 1.0 antiseptic 0.3 0.3 0.3 Polydecene 4.0 4.0 4.0 Meadowfoam seed oil 1.0 1.0 1.0 Pentaerythritol tetraisostearate 3.0 3.0 3.0 Dimethicone 0.5 0.5 0.5 Cetyloctanoate 2.0 2.0 2.0 Decyl cocoate 1.0 1.0 1.0 Cyclomethicone 3.0 3.0 3.0 Tocopheryl acetate 0.1 0.1 0.1 Awards
ingredient Purified water To 100 To 100 To 100 Butylene glycol 5.0 5.0 5.0 Disodium ID 0.02 0.02 0.02 Tee 0.15 0.15 0.15 antiseptic 0.2 0.2 0.2 White birch extract (Preparation Example 1) 1.0 10.0 -

<Production method of Examples 1 and 2 and Comparative Example 1>

(1) The oily ingredients were heated (70-75 ° C.) and mixed uniformly.

(2) The aqueous phase components were heated (70-75 ° C.) to be uniformly dissolved and mixed.

(3) While maintaining the temperature at 70 ~ 75 ℃ under stirring (1) to the above (2) to make an emulsion to cool to 28 ~ 30 ℃.

[Test Example 2] Subjective efficacy evaluation on the skin dryness improvement effect

Example 1 to 2 and Comparative Example 1 were allowed to be used by the test subjects of Test Example 1 for 2 weeks, and then a questionnaire was prepared to evaluate subjective efficacy for improving skin dryness. The survey results are shown in Table 3 below.

Survey on Improvement of Dry Skin Applicator Respondents Very good Good usually Inadequate Example 1 30% 50% 20% 0% Example 2 30% 40% 30% 0% Comparative Example 1 0% 10% 30% 60%

From the results of Table 3, it can be seen that the sites to which Examples 1 to 2 containing the baekhwasachocho extract of the present invention feel relatively moisturizing effect than the site of Comparative Example 1 containing baekhwasachocho extract. there was. Therefore, the composition for external application for skin containing the baekrye-saengchoe extract of the present invention can improve the skin dryness by excellent skin moisturizing effect.

Claims (2)

Skin external composition for moisturizing baekhwasachocho extract as an active ingredient. The external composition for moisturizing skin according to claim 1, wherein the baekhwasachocho extract is contained in an amount of 0.0001 to 50% by weight based on the total weight of the composition.