KR20110013000A - Cosmetic composition for moisturizing skin which alleviates itchiness and dryness by removing keratin and increasing moisture - Google Patents

Abstract

PURPOSE: A cosmetic composition containing lactic acid derivative and urea is provided to remarkably moisturize with effects of removing keratin and enhancing moisture. CONSTITUTION: A cosmetic composition for moisturizing contains 1-weight% of urea and lactic acid derivative. The lactic acid derivative is potassium lactate, zinc lactate, calcium lactate, potassium lactate, magnesium lactate, copper lactate, manganases lactate, boron lactate or ammonium lactate. The composition is used for treating aged skin and keratinized skin for the old people.

Description

Cosmetic composition for moisturizing skin which alleviates itchiness and dryness by removing keratin and increasing moisture}

The present invention relates to a moisturizing cosmetic composition.

The skin is divided into three layers of epidermis, dermis and subcutaneous tissue in order from the outside, and it protects the organs of the body from temperature and humidity changes, ultraviolet rays and other physical and chemical external stimuli. In particular, the epidermis plays an important role in preventing evaporation of moisture inside the human body. The epidermis is divided into the stratum corneum, granule layer, the polar layer and the basal layer in order from the outside, the cells of the stratum corneum acts like a brick, and the intercellular lipids between the stratum corneum acts as a mortar to form the skin barrier. In keratinocytes of healthy people, a high concentration of natural moisturizing factor (NMF) is present, which combines with moisture to inhibit the drying of moisture from the skin.

However, these days, the artificial temperature control of air conditioning and heating according to the change of environment and life patterns, the skin stress caused by various stresses and environmental pollution that occur in social life, the frequent face wash due to makeup habits and the increase of age Due to various causes such as aging of the skin, the moisture of the stratum corneum decreases, the skin becomes dry, the surface becomes rough, and the skin becomes crumbly and loses luster, and the appearance of dullness occurs.

Conventionally, as a moisturizer, a humectant having a property of absorbing water or an occlusive moisturizer that prevents evaporation of water is used. However, this type of moisturizer has a low sustainability against a moisturizing feeling and has no exfoliation effect. You will need another product for.

The present inventors have found that when combining urea and lactic acid derivatives, the skin's moisture persistence is increased and the dead skin is effectively removed to smooth out rough skin. Therefore, it is to provide a moisturizing cosmetic composition containing a lactic acid derivative and urea, the aging exfoliation effect and the moisture increase effect has a synergistic effect with each other showing a markedly improved moisturizing effect.

The present invention provides a moisturizing cosmetic composition containing urea and lactic acid derivatives.

As a result of using the moisturizing cosmetic composition according to an embodiment of the present invention, the aging exfoliation effect and the moisture increase effect showed synergistic effects, and thus a remarkably improved moisturizing effect was shown. The result is skin softness, reduced cracking and roughness, as well as itching due to dryness.

The present inventors focused on the relationship between healthy stratum corneum and moisturizing, and prepared a composition including both lactic acid derivative component and urea component having both moisturizing and skin softening effects while simultaneously removing aging keratin. As a result, the aging keratin or hyper- keratinized skin removal effect and the moisture increase effect has a synergistic effect to provide a moisturizing cosmetic composition significantly improved moisturizing effect. Moisturizing cosmetic composition of the present invention has both an angular mass reduction effect and skin moisture increase effect. Thus, the moisturizing effect in the present invention includes the effect of increasing water and the exfoliation effect.

In one embodiment of the present invention, urea is a kind of natural moisturizing factor (NMF) present in the skin, which is combined with moisture to inhibit drying of the moisture from the skin. Urea is non-toxic, does not cause allergies, and is colorless and fragrance-free.

In one embodiment of the present invention the lactic acid derivative is potassium lactate, zinc lactate, calcium lactate, potassium lactate, magnesium lactate, zinc lactate, copper lactate, manganese lactate, boron lactate or ammonium lactate It may include and remove aging keratin or hyperkeratinized skin. In one embodiment of the present invention, the term "aging keratin" is a stratum corneum including keratinocytes in the dropping stage as they are differentiated from keratinocytes, and the amount of moisturizing factors and lipids retained is reduced to dryness and skin. Keratin lost the barrier function.

Moisturizing cosmetic composition according to an embodiment of the present invention may comprise 1 to 50% by weight of urea based on the total weight of the composition. If it is less than 1% by weight, it is difficult to obtain the expected effect. If it is more than 50% by weight, skin irritation may occur.

Moisturizing cosmetic composition according to an embodiment of the present invention may include lactic acid derivative 1 to 50% by weight based on the total weight of the composition. If it is less than 1% by weight, the expected effect is difficult to obtain, and if it is more than 50% by weight, skin irritation may occur.

In one embodiment of the present invention, the angular mass reduction effect of the lactic acid derivative and the moisture increase effect of urea may exhibit a synergistic effect. In the test example of the present invention, when the lactic acid derivative and the urea were used alone, the angular mass reduction effect and the moisture increase effect were remarkably improved.

Moisturizing cosmetic composition according to an embodiment of the present invention may be a moisturizing cosmetic composition for the elderly. The skin of the elderly due to aging, the fall of aging keratinocytes is not smooth, thick stratum corneum, the lipid synthesis activity of the stratum corneum is reduced, the amount of moisturizing factors and lipids of the stratum corneum is reduced, the skin has a dry characteristic. Moisturizing cosmetic composition according to an embodiment of the present invention is excellent in both the moisture increase effect and angular mass reduction effect, it can be used for the aged skin.

In addition, the cosmetic composition according to an embodiment of the present invention is a moisturizing cosmetic composition that is significantly improved moisturizing effect by showing the synergistic effect of aging keratin or hyper- keratinized skin removal effect and moisture increase effect each other, aging skin, young Keratinized skin disease such as glandular skin or may be a cosmetic composition for skin exfoliated due to external stimuli such as friction.

One embodiment of the present invention provides a cosmetic composition comprising a urea and lactic acid derivative. The appearance of a cosmetic comprising a cosmetic composition according to an embodiment of the present invention contains a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing the oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases, and It may be provided in the form of a nonionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray or cone stick. These compositions may be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

Cosmetic compositions may include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers Cosmetic or dermatology such as metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in cosmetics It may contain adjuvants commonly used in the art. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.

Cosmetic compositions containing urea and lactic acid derivatives are not particularly limited in the formulation, for example, softening longevity, astringent longevity, nourishing longevity, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, It may be formulated into a cosmetic such as cleansing foam, cleansing water, pack, powder, body lotion, body cream, body oil and body essence.

Hereinafter, the Example and comparative example of this invention are demonstrated more concretely. However, the embodiment described below is only one embodiment of the present invention, the present invention is not limited to such an embodiment.

[Examples 1-13 and Comparative Examples 1-6]

Cosmetic emulsions comprising the ingredients described in Tables 1 and 2 below were prepared by conventional methods known in the art (unit: wt%). Distilled water was dissolved in lactic acid derivatives, urea, carbomer and mixed for 3 minutes at 7000rpm and then sodium hydroxide was added to homomixing (homomixing).

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Potassium lactate 20.0 20.0 20.0 50.0 Zinc lactate 20.0 Calcium lactate 20.0 Potassium lactate Magnesium lactate Zinc lactate Copper lactate Manganese lactate Boron lactate Ammonium lactate Urea 7.0 1.0 50.0 7.0 1.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 71.0 77.0 28.0 41.0 77.0 77.0

ingredient Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Potassium lactate Zinc lactate Calcium lactate Potassium lactate 20.0 Magnesium lactate 20.0 Zinc lactate 20.0 Copper lactate 20.0 Manganese lactate 20.0 Boron lactate 20.0 Ammonium lactate 20.0 Urea 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 77.0 77.0 77.0 77.0 77.0 77.0 77.0

ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Sodium lactate - 20.0 - - - - Potassium lactate - - 20.0 - - 1.0 Urea - - - 7.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 97.8 77.8 77.8 90.8 96.8 96.8

[Test Example]

In order to determine the water content increase and the angular mass reduction efficacy of Examples 1 to 13 and Comparative Examples 1 to 6 prepared above, 48 men and women in their 20s and 50s were tested.

1) After washing the forearm (forearm), it was stabilized by waiting at least 30 minutes in a constant temperature and humidity room (24 ℃, 40% relative humidity).

2) The skin moisture content was measured using a conniometer, which calculates the amount of moisture present in the skin's epidermis by measuring and quantifying the degree of moisture in the sensor. In addition, after collecting keratin from the test area at each time point using black tape (D-squame®), the area of the keratin using the Charmview scope (Moritex, Japan) (pixel number) was obtained.

3) After apply | coating the composition of Examples 1-13 and Comparative Examples 1-6 to an electric foil, water content and angular mass were confirmed by the same method as mentioned above in the same site | part after 8 hours.

The increase rate of water due to the change in moisture content before and after application of the compositions of Examples and Comparative Examples is shown in Table 3, and the decrease rate of keratin according to the change of angular mass is shown in Table 4. In addition, digital photographs before and after applying Comparative Examples 1 and 2, Examples 1 and 2 compositions are shown in Figs. When the Examples 1 and 2 are applied to the digital photograph of FIGS. 1 to 4, it can be seen that the amount of keratin attached to the black tape is significantly reduced.

According to Tables 3 and 4, it can be seen that the moisture increase rate and the keratin reduction rate are remarkable when the cosmetic compositions of Examples 1 to 13 of the present invention are applied to the cosmetic compositions of Comparative Examples 1 to 6, respectively. In particular, the water increase rate and the keratin loss rate of Examples 1 and 2 of the present invention are significantly higher than the sum of the water increase rate and the keratin decrease rate of Comparative Examples 3 to 5 each using potassium lactate and urea, which are lactic acid derivatives, alone, It can be seen that the lactic acid derivative and the urea are used together to exhibit synergistic effects.

Kinds Moisture growth rate (%) After 8 hours Example 1 175 Example 2 167 Example 3 183 Example 4 201 Example 5 158 Example 6 162 Example 7 173 Example 8 163 Example 9 168 Example 10 173 Example 11 166 Example 12 178 Example 13 157 Comparative Example 1 8 Comparative Example 2 24 Comparative Example 3 87 Comparative Example 4 17 Comparative Example 5 11 Comparative Example 6 14

Kinds Keratin loss rate (%) After 8 hours Example 1 -141 Example 2 -125 Example 3 -176 Example 4 -193 Example 5 -118 Example 6 -126 Example 7 -123 Example 8 -122 Example 9 -137 Example 10 -128 Example 11 -116 Example 12 -120 Example 13 -121 Comparative Example 1 -2 Comparative Example 2 -54 Comparative Example 3 -77 Comparative Example 4 -11 Comparative Example 5 -7 Comparative Example 6 -8

Examples of the formulation of the composition according to the present invention are described below, but are also applicable to various other formulations, which are intended to explain in detail only and not intended to limit the present invention.

Formulation Example 1 Flexible Cosmetic (Skin Lotion)

According to the composition shown in Table 5 was prepared in the conventional method for the flexible cosmetic.

Compounding ingredient Content (% by weight) Urea 2.0 Potassium lactate 5.0 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 2 Nutritious Longevity (Milk Lotion)

Nutritional longevity was prepared according to the composition described in Table 6 below in a conventional manner.

Compounding ingredient Content (% by weight) Urea 5.0 Potassium lactate 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Beeswax 4.0 Polysorbate 60 1.5 Caprylic / Capric Triglycerides 5.0 Squalane 5.0 Sorbitassquioleate 1.5 Liquid paraffin 0.5 Cetearyl Alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 3 Nutrition Cream

Nutritional cream was prepared in a conventional manner according to the composition shown in Table 7. 5 shows that keratin was decreased before and after the application of Formulation Example 3.

Compounding ingredient Content (% by weight) Urea 7.0 Potassium lactate 7.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 4 Massage Cream

To prepare a massage cream in a conventional manner according to the composition shown in Table 8.

Compounding ingredient Content (% by weight) Urea 8.0 Potassium lactate 5.0 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Beeswax 4.0 Cetearyl Glucoside 1.5 Sesqui oleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Quantity Purified water Balance

[Formulation Example 5] Pack

To prepare a pack in a conventional manner according to the composition described in Table 9.

Compounding ingredient Content (% by weight) Urea 8.0 Potassium lactate 8.0 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl Phenyl Ether 0.4 Polysorbate 60 1.2 ethanol 6.0 Preservative, coloring, fragrance Quantity Purified water Balance

Although the present invention has been described in connection with the above-mentioned embodiments, it is possible to make various modifications or variations without departing from the spirit and scope of the invention. Accordingly, the appended claims are intended to cover such modifications or changes as fall within the scope of the invention.

1 is a photograph showing keratin collected before and after applying Comparative Example 1 of the present invention.

2 is a photograph showing keratin taken before and after applying Comparative Example 2 of the present invention.

3 is a photograph showing keratin taken before and after applying Example 1 of the present invention.

4 is a photograph showing keratin taken before and after applying Example 2 of the present invention.

5 is a photograph showing that keratin was decreased before and after applying Formulation Example 3. FIG.

Claims (9)

Moisturizing cosmetic composition containing urea and lactic acid derivatives. The method of claim 1, wherein the lactic acid derivative is selected from potassium lactate, zinc lactate, calcium lactate, potassium lactate, magnesium lactate, zinc lactate, copper lactate, manganese lactate, boron lactate and ammonium lactate. Moisturizing cosmetic composition, characterized in that at least one selected. The moisturizing cosmetic composition according to claim 1, wherein the composition comprises 1-50% by weight of lactic acid derivative based on the total weight of the composition. The moisturizing cosmetic composition according to claim 1, wherein the composition comprises 1 to 50% by weight of urea, based on the total weight of the composition. The moisturizing cosmetic composition according to any one of claims 1 to 4, wherein the composition reduces the angular mass. The moisturizing cosmetic composition according to any one of claims 1 to 4, wherein the composition increases skin moisture content. 6. The moisturizing cosmetic composition according to claim 5, wherein the keratin is aging keratin or hyperkeratinized skin. The moisturizing cosmetic composition according to any one of claims 1 to 4, wherein the composition is for elderly people. The moisturizing cosmetic composition according to any one of claims 1 to 4, wherein the composition is for aging skin, keratinized skin disease skin or hyperkeratinized skin.

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