KR101605324B1 - Cosmetic composition for moisturizing skin which alleviates itchiness and dryness by removing keratin and increasing moisture - Google Patents

Abstract

A lactic acid derivative, and a urea. As a result of using the moisturizing cosmetic composition according to one embodiment of the present invention, the aging skin exfoliation effect and the water increasing effect were synergistic with each other, showing remarkably improved moisturizing effect. As a result, the skin became soft, cracked and rough, and the itching caused by drying was alleviated.

Itching relief, moisturizing, lactic acid derivatives, urea, exfoliation, skin, moisture increase

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition for moisturizing and moisturizing skin, which comprises an extract of keratin and increasing moisture,

The present invention relates to a cosmetic composition for moisturizing.

The skin is largely divided into three layers of epidermis, dermis and subcutaneous tissue from the outside in order. It protects the internal organs of the body from changes in temperature and humidity, ultraviolet rays, and other physical and chemical external stimuli. Especially, the epidermis plays an important role in preventing water evaporation inside the human body. The epidermis is divided into the stratum corneum, granular layer, the superficial layer and the basal layer in order from the outside. Cells of the stratum corneum act like bricks, and intercellular lipids between keratinocytes function as mortar to constitute skin barrier. Healthy human keratinocytes have a high concentration of natural moisturizing factor (NMF), which binds with moisture to inhibit drying of water from the skin.

However, as it is nowadays, there is a tendency to adjust the temperature of the air / heating due to the change of environment or life pattern, the stress caused by various stresses and environmental pollution in the social life, frequent washing according to make- Due to various causes such as aging of skin and the like, moisture of the stratum corneum is reduced, and the skin becomes dry, the surface becomes rough, the skin becomes loose, the luster is lost and the skin looks dull, and the need for skin moisturizing agent is increasing.

Humectants and occlusive moisturizers, which have the property of absorbing moisture, have been used in the past as moisturizers, but these types of moisturizers have low persistence to moisturizing effect and have no exfoliating effect. Therefore, You will need another product for.

The present inventors have found that when blending urea and lactic acid derivatives, they increase the moisture retention of the skin and effectively remove old horny substances and smooth the rough skin. Accordingly, it is intended to provide a cosmetic composition for moisturizing which contains a lactic acid derivative and urea, exhibits a synergistic effect with aging exfoliating effect and water-increasing effect, and shows remarkably improved moisturizing effect.

The present invention provides a moisturizing cosmetic composition containing urea and a lactic acid derivative.

As a result of using the moisturizing cosmetic composition according to one embodiment of the present invention, the aging skin exfoliation effect and the moisture increasing effect were synergistic with each other, showing remarkably improved moisturizing effect. As a result, the skin became soft, cracked and rough, and the itching caused by drying was alleviated.

The present inventors focused on the relationship between a healthy stratum corneum and moisturizing, and prepared a composition containing both a lactic acid derivative component that simultaneously alleviates aging keratin and helps moisturize the skin, and a urea component that simultaneously has a moisturizing effect and a skin cleansing effect. As a result, there has been provided a moisturizing cosmetic composition in which moisturizing effect is remarkably improved due to synergistic effect between aged keratin or hyperkeratotic skin removing effect and moisture increasing effect. The cosmetic composition for moisturizing of the present invention has both effects of mass reduction and increase in skin moisture content. Accordingly, in the present invention, the moisturizing effect includes a water-increasing effect and an exfoliation effect.

In one embodiment of the present invention, urea is a type of natural moisturizing factor (NMF) present in the skin, and binds with moisture to inhibit drying of moisture from the skin. Urea is not toxic, does not cause allergies, has colorless, odorless properties.

In one embodiment of the invention, the lactic acid derivative is selected from the group consisting of potassium lactate, zinc lactate, calcium lactate, potassium lactate, magnesium lactate, zinc lactate, copper lactate, manganese lactate, boron lactate or ammonium lactate And may remove aging keratin or hyperkeratotic skin. In one embodiment of the present invention, the term "aging keratin," refers to a horny layer containing keratinocytes that are differentiated from keratinocytes and that are in a collapsing stage according to a period of time. The amount of moisturizing factors and lipids It means keratin which lost barrier function.

The moisturizing cosmetic composition according to an embodiment of the present invention may contain 1 to 50% by weight of urea based on the total weight of the composition. If it is less than 1% by weight, it is difficult to obtain an expected effect, and if it exceeds 50% by weight, skin irritation may occur.

The cosmetic composition for moisturizing according to an embodiment of the present invention may contain 1 to 50% by weight of the lactic acid derivative based on the total weight of the composition. If it is less than 1% by weight, it is difficult to obtain an expected effect. If it exceeds 50% by weight, skin irritation may occur.

In one embodiment of the present invention, the effect of reducing the mass of each of the lactic acid derivatives and the effect of increasing the water content of the urea may exhibit a synergistic effect with each other. In the test examples of the present invention, when the lactic acid derivative and urea were simultaneously used, the mass reduction effect and the water increase effect were remarkably improved, respectively, as compared with the case where the lactic acid derivative and urea were used singly.

The cosmetic composition for moisturizing according to an embodiment of the present invention may be a cosmetic composition for moisturizing for the elderly. The elderly skin is aged, the detachment of aging keratinocyte is not smooth, the stratum corneum is thick, the lipid synthesis activity of the stratum corneum is lowered, and the amount of moisturizing factor and lipid in the stratum corneum of the skin is reduced, and the skin is dried. The cosmetic composition for moisturizing according to an embodiment of the present invention is excellent in both water-increasing effect and mass-reducing effect, and thus can be used for the elderly skin.

In addition, the cosmetic composition according to one embodiment of the present invention is a cosmetic composition for moisturizing which shows a synergistic effect of aging keratin or hyperkeratinized skin removing effect and moisture increasing effect and remarkably improving moisturizing effect. Therefore, Such as skin or friction, due to external stimuli, such as skin or skin friction, can be a hyperpigmented cosmetic composition for the skin.

One embodiment of the present invention provides a cosmetic composition comprising urea and a lactic acid derivative. The cosmetic composition comprising the cosmetic composition according to one embodiment of the present invention comprises a cosmetically or dermatologically acceptable medium or base. It may be in any form suitable for topical application, for example, as a solution, a gel, a solid, a paste anhydrous product, an emulsion obtained by dispersing the oil phase in water, a suspension, a microemulsion, a microcapsule, In the form of a non-ionic follicle dispersing agent, or in the form of creams, skins, lotions, powders, ointments, sprays or conical sticks. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition may further comprise at least one selected from the group consisting of fatty substances, organic solvents, solubilizers, thickening agents, gelling agents, softening agents, antioxidants, suspending agents, stabilizing agents, foaming agents, fragrances, surfactants, water, , Cosmetics or dermatology such as metal ion sequestrants, chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredient commonly used in cosmetics May contain adjuvants commonly used in the art. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields.

The cosmetic composition containing urea and lactic acid derivatives is not particularly limited in its formulation, and examples thereof include softening lotion, convergent lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, eye essence, Cosmetics such as cleansing foams, cleansing water, packs, powders, body lotions, body creams, body oils and body essences.

Hereinafter, examples and comparative examples of the present invention will be described in more detail. However, the embodiments described below are only examples of the present invention, and the present invention is not limited to these embodiments.

[Examples 1 to 13 and Comparative Examples 1 to 6]

Cosmetic emulsions containing the ingredients listed in the following Tables 1 and 2 were prepared by a conventional method known in the art (unit: wt%). Lactic acid derivatives and urea were dissolved in distilled water, added to carbomer, mixed thoroughly at 7000 rpm for 3 minutes, and homomixing was performed by adding sodium hydroxide.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Potassium lactate 20.0 20.0 20.0 50.0 Zink Lacate 20.0 Calcium lactate 20.0 Potassium lactate Magnesium lactate Zinc lactate Copper lactate Manganese lactate Boron lactate Ammonium lactate Urea 7.0 1.0 50.0 7.0 1.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 71.0 77.0 28.0 41.0 77.0 77.0

ingredient Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Potassium lactate Zink Lacate Calcium lactate Potassium lactate 20.0 Magnesium lactate 20.0 Zinc lactate 20.0 Copper lactate 20.0 Manganese lactate 20.0 Boron lactate 20.0 Ammonium lactate 20.0 Urea 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 77.0 77.0 77.0 77.0 77.0 77.0 77.0

ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Sodium lactate - 20.0 - - - - Potassium lactate - - 20.0 - - 1.0 Urea - - - 7.0 1.0 Carbomer 2.0 2.0 2.0 2.0 2.0 2.0 Sodium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2 Distilled water 97.8 77.8 77.8 90.8 96.8 96.8

[Test Example]

In order to investigate the effect of increasing the water content and reducing the mass of each of Examples 1 to 13 and Comparative Examples 1 to 6 prepared above, 48 men and women in 20-50 years were experimented.

1) After washing the forearms, they were kept in a constant temperature and humidity room (24 ℃, relative humidity 40%) for more than 30 minutes.

2) The moisture content of the skin was measured using a coneometer which calculates the amount of water present in the epidermis of the skin by measuring and quantifying the degree of water ion using a sensor. In addition, keratin was collected from the test site at each time point using a black tape (D-squame®), and the keratin attached to the black tape was measured using a Charmview scope (Moritex, Japan) (pixel number) was obtained.

3) The compositions of Examples 1 to 13 and Comparative Examples 1 to 6 were applied to all the pellets, and after 8 hours, the amount of water and the respective mass were confirmed in the same manner as described above.

Table 3 shows the rate of water increase due to the change in water content before and after application of the compositions of Examples and Comparative Examples, and Table 4 shows the reduction rate of keratin according to each mass change. Digital photographs before and after applying the compositions of Comparative Examples 1 and 2 and Examples 1 and 2 are shown in Figs. It can be seen that when applying the examples 1 and 2 in the digital photographs of FIGS. 1 to 4, the amount of keratinous substance attached to the black tape was remarkably reduced.

According to Tables 3 and 4, when the cosmetic compositions of Examples 1 to 13 of the present invention were applied to the cosmetic composition of Comparative Examples 1 to 6, it was confirmed that the rate of water increase and the rate of reduction of horny hair were remarkable. Particularly, the water increase rate and keratin reduction rate of Examples 1 and 2 of the present invention were significantly higher than those of Comparative Examples 3 to 5 in which the lactate derivatives, potassium lactate and urea, Lactic acid derivative and urea were used together to show a synergistic effect with each other.

Kinds Moisture growth rate (%) After 8 hours Example 1 175 Example 2 167 Example 3 183 Example 4 201 Example 5 158 Example 6 162 Example 7 173 Example 8 163 Example 9 168 Example 10 173 Example 11 166 Example 12 178 Example 13 157 Comparative Example 1 8 Comparative Example 2 24 Comparative Example 3 87 Comparative Example 4 17 Comparative Example 5 11 Comparative Example 6 14

Kinds Percent reduction of keratin (%) After 8 hours Example 1 -141 Example 2 -125 Example 3 -176 Example 4 -193 Example 5 -118 Example 6 -126 Example 7 -123 Example 8 -122 Example 9 -137 Example 10 -128 Example 11 -116 Example 12 -120 Example 13 -121 Comparative Example 1 -2 Comparative Example 2 -54 Comparative Example 3 -77 Comparative Example 4 -11 Comparative Example 5 -7 Comparative Example 6 -8

Formulation examples of the composition according to the present invention will be described below, but the present invention can be applied to various other formulations, which are not intended to limit the present invention but to describe it specifically.

[Formulation Example 1] Softening lotion (skin lotion)

The softening longevity was prepared by a conventional method according to the composition shown in Table 5 below.

Compounding ingredient Content (% by weight) Urea 2.0 Potassium lactate 5.0 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxyvinyl polymer 0.1 Phage-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 2] Nutritional lotion (Milk lotion)

Nutrition lotion was prepared according to a conventional method according to the composition shown in Table 6 below.

Compounding ingredient Content (% by weight) Urea 5.0 Potassium lactate 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Wax 4.0 Polysorbate 60 1.5 Caprylic / capric triglyceride 5.0 Squalane 5.0 Sorbitacecequioleate 1.5 Liquid paraffin 0.5 Cetearyl alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 3] Nourishing cream

Nutritive creams were prepared according to the compositions listed in Table 7 below in a conventional manner. FIG. 5 shows that the keratinization was reduced before and after Formulation Example 3 was applied.

Compounding ingredient Content (% by weight) Urea 7.0 Potassium lactate 7.0 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Squalane 5.0 Cetearyl glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 4] Massage cream

Massage creams were prepared in a conventional manner according to the composition shown in Table 8 below.

Compounding ingredient Content (% by weight) Urea 8.0 Potassium lactate 5.0 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / capric triglyceride 3.0 Wax 4.0 Cetearyl glucoside 1.5 Sesquioleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Suitable amount Purified water Balance

[Formulation Example 5] Pack

Packs were prepared in a conventional manner according to the composition shown in Table 9 below.

Compounding ingredient Content (% by weight) Urea 8.0 Potassium lactate 8.0 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl phenyl ether 0.4 Polysorbate 60 1.2 ethanol 6.0 Preservative, coloring, fragrance Suitable amount Purified water Balance

Although the present invention has been described in connection with the above-mentioned embodiments, it is possible to make various modifications and variations without departing from the spirit and scope of the present invention. Accordingly, the appended claims are intended to cover such modifications or changes as fall within the scope of the invention.

Fig. 1 is a photograph showing keratin formed before and after application of Comparative Example 1 of the present invention. Fig.

Fig. 2 is a photograph showing keratin formed before and after application of Comparative Example 2 of the present invention. Fig.

Fig. 3 is a photograph showing keratin before and after application of Example 1 of the present invention. Fig.

4 is a photograph showing keratin before and after application of the second embodiment of the present invention.

Fig. 5 is a photograph showing the decrease in keratin before and after application of Formulation Example 3. Fig.

Claims (9)

7 to 50% by weight, based on the total composition weight, of urea; And 20 to 50% by weight of a lactic acid derivative which is at least one selected from the group consisting of potassium lactate, calcium lactate, zinc lactate, copper lactate, manganese lactate, boron lactate and ammonium lactate. The cosmetic composition for exfoliating according to claim 1, wherein the composition contains urea and potassium lactate. The cosmetic composition for exfoliating according to claim 1, wherein the composition contains 50% by weight of urea and 20% by weight of a lactic acid derivative. The cosmetic composition for exfoliating according to claim 1, wherein the composition contains 7% by weight of urea and 50% by weight of a lactic acid derivative. delete delete The cosmetic composition for exfoliating according to any one of claims 1 to 4, wherein the keratin is an aging keratin or a hyperkeratotic skin. The cosmetic composition for exfoliating according to any one of claims 1 to 4, wherein the composition is for the elderly. The cosmetic composition for exfoliating according to any one of claims 1 to 4, wherein the composition is for aging skin, keratinized skin disease or hyperkeratosis skin.

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