JPS624362B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a skin moisturizer, particularly a moisturizing skin cosmetic, which contains as an active ingredient a polysulfate ester of chondroitin sulfate extracted from animal organs. In normal human skin, moderate sebum (Sebum)
The various triglycerides, waxes, cholesterol, squalene, paraffinic hydrocarbons, and other components contained in these act as moisturizing ingredients that prevent the skin from becoming too dry and maintain its suppleness. ing. However, in aged skin, rough skin, or skin that has frequently used detergents, the skin becomes dry and rough due to a lack of sebum. As mentioned above, when the natural moisturizing effect is insufficient, artificially replenishing the skin with moisturizing substances to prevent the skin from drying out has been practiced for a long time.For example, it has been used in cosmetics. It is well known that moisturizing agents such as glycerin, propylene glycol, sorbitol, or diethylene glycol monoethyl ether (or monomethyl ether) are commonly included in the formulation. By the way, moisturizers applied to human skin are
For this purpose, it is desirable to have the property of retaining moisture without evaporating when the humidity in the air is low, while not absorbing moisture above a certain limit even when the humidity is high. In other words, the ideal moisturizer is Natural
Sodium pyrrolidone carboxylate is a representative of Moisturizing Factor (NMF: a metabolic product of keratinization or a highly hygroscopic substance derived from sweat as a physiological moisturizing component on the skin surface).
It should have performance equivalent to or better than pyrrolidone carboxylate (PCA-Na)). However, the above-mentioned known moisturizers have excessive hygroscopicity,
It has the disadvantage of being easily sticky. In recent years, mucopolysaccharides have attracted attention as they have better moisturizing effects than the above-mentioned PCA, and various cosmetics containing chondroitin sulfate or hyaluronic acid, which belong to these mucopolysaccharides, have been investigated, and some of them have been Cosmetics containing it are commercially available. The present inventor has developed a polysulfate ester of chondroitin sulfate (hereinafter abbreviated as CPS) extracted from animal organs.
As a result of intensive research on the moisturizing effect of esters, it was found that these esters are far superior to the above-mentioned chondroitin sulfate and hyaluronic acid as humectants. This CPS is a heparinoid substance,
It is known to have antithrombin effects, anticoagulant effects, and peripheral blood circulation promoting effects.
Its moisturizing effect, especially its moisturizing effect in skin cosmetics, was unknown until now. Incidentally, the present inventors measured the water content of the stratum corneum of the skin as a means of objectively measuring the moisturizing effect.
H., Ohi, M., Iwatsuki, K., Kanamaru, Y.,
Yamada M and Ichijo, B.: Evaluation of the
skin surface hydration in vivo by electrical
measurement, J. Invest. Dermatol., 75, : 500
We adopted a high-frequency conduction measurement method (impedance meter method) developed by J.D.-507, 1980), and found that this measurement method corresponded well with the sensory observation results. [Experiment method] Using an impedance meter, (1a) 0.3%
Comparison of the moisturizing effects of CPS-containing ointment, (1b) 0.1% CPS-containing ointment, and (1c) base, and (2a) 0.3% CPS-containing ointment and commercial product A (main ingredient: urea) that claims a moisturizing effect. ), B (main ingredient: soluble collagen), C (main ingredient: hyaluronic acid), and D (main ingredient: natural moisturizing ingredient analogue) were examined under the following conditions. Subjects: 5 men, 5 women Application method: Site: Inside of left and right forearms, Area: approx. 13 cm ² , Amount: 50μ or more The results of experiments (1a), (1b), and (1c) are shown in Tables 1 and 1. Figure 1 shows experiments (2a), (2-A), (2-
The results of B), (2-C) and (2-D) are shown in Table 2 and FIG.

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[Table] As shown in Table 1 and Figure 1, the ointment containing 0.3% CPS had a noticeable moisturizing effect from 30 minutes after application, and the effect continued even 6 hours after application. The ointment containing 0.1% CPS showed a higher moisturizing effect than the base after 4 hours;
Even after the passage of time, the value remained higher than before application, indicating that it had a high moisturizing effect. In comparing the moisturizing effects of ointments containing 0.3% CPS shown in Table 2 and Figure 2 with general commercial products (drugs and quasi-drugs) that claim to have a moisturizing effect, Pharmaceutical A, which has urea as its main ingredient, Immediately after application, it showed a relatively high moisturizing effect, but the moisturizing ability decreased over time, and 6 hours after application, it decreased to almost the value before application.
Furthermore, quasi-drug B containing soluble collagen as a main component did not exhibit particularly large moisturizing effects except immediately after application. Furthermore, C (quasi-drug, ointment) containing hyaluronic acid as an active ingredient, contrary to expectations,
As early as 30 minutes after application, the value decreased to the value before application. The moisturizing effect of all of A, B and C almost disappeared after 6 hours. Finally, although quasi-drug D containing analogues of natural moisturizing ingredients showed a relatively high value even 6 hours after application, its moisturizing effect was lower than that of the product of the present invention (containing 0.3% CPS). It was inferior. From these experimental results, it is clear that the CPS-containing skin moisturizer according to the present invention has a better moisturizing effect than existing commercially available products. In addition to the above-mentioned experiments, the inventors also conducted in vivo tests similar to those listed in the preceding tables using an ointment containing chondroitin sulfate (ChS), which has been conventionally used as a moisturizing agent for cosmetics, as a control. However, the subjects in this case are 5 males. The results are shown in Table 3 below and Figure 3. As shown in the table (figure), the CPS-containing ointment according to the invention shows a clear moisturizing ability compared to the control ChS-containing ointment after 30 minutes of application, and shows the highest level of moisturizing even after 6 hours. is seen.

[Table] The present invention is based on the above findings, and its gist lies in the use of CPS as a skin moisturizer. To achieve this objective, the skin moisturizer according to the present invention preferably includes a cleansing agent such as a cosmetic soap, a transparent soap, or a cleansing cream, a cold cream, a hand cream, a vanishing cream, a foundation cream, a hormone cream ( Creams such as emollient cream containing estrogen), lotions such as plant juice lotions, alkaline lotions, astringent lotions, hand lotions, milky lotions, foundation lotions, and cleansing lotions. It is applied to human skin in the form of cosmetics such as powder, water, and kneaded products, as well as lipstick. Raw materials for these preparations include animal and vegetable oils and fats, animal and vegetable waxes, squalane, lanolin, microcrystalline wax, ceresin wax, paraffin wax, petrolatum, liquid paraffin, higher fatty acids, higher fatty alcohols,
Higher fatty esters, various surfactants, natural or semi-synthetic polysaccharides and their derivatives, glycerin,
Known cosmetic raw materials such as propylene glycol, sorbitol, various disinfectants or preservatives, antioxidants, various flavoring agents, fillers (excipients), and coloring agents are used. CPS is usually 0.1-1.0 in the composition
%, preferably within the range of 0.1 to 0.3%. Hereinafter, embodiments of the invention will be described with reference to Examples, but the examples are merely for illustration purposes and are not intended to limit the scope of the invention. Example 1 (Hand Cream) After preheating the following ingredients to 70 to 75°C, stir and emulsify using a homomixer, cool, and if necessary homogenize through a homogenizer.
Product. Prescription example 1 White petrolatum 10.0g Setanol 10.0g Lanolin alcohol 5.0g Cholesterol 1.0g Glyceryl monostearate 1.0g Polyoxyethylene cetyl ether 1.0g CPS 0.3g Water Dosage meter 100.0g Prescription example 2 Liquid paraffin 30.0g Setanol 3.0g Paraffin wax Tsukusu 5.0g Proprene glycol 5.0g Glyceryl monostearate 1.8g Polyoxyethylene monostearate 2.0g CPS 0.1g Water Dosage meter 100.0g Prescription example 3 White petrolatum 25.0g Stearyl alcohol 22.0g Propylene glycol 12.0g Sodium lauryl sulfate 1.5g Ethyl paraoxybenzoate 0.025g Propyl paraoxybenzoate 0.015g CPS 0.3g Water Dosage meter 100.0g Example 2 (Hand lotion) The following ingredients are stirred and mixed using a homomixer to prepare a product. Prescription example 4 Sorbitol 4.0g Citric acid 0.9g Ethanol 10.0ml Methylparaben 0.1g CPS 0.3g Water Dosage meter 100.0g Prescription example 5 (Same as above) Triethanolamine 0.2g 1,3-butylene glycol 7.0g Ethanol 20.0ml Methylparaben 0.1g CPS 0.3g water dosage meter 100.0g

[Brief explanation of the drawing]

Figure 1 shows a CPS-containing ointment according to the present invention and a control
A graph comparing the moisturizing effect of CPS-free ointments, Figure 2 is a graph comparing the moisturizing effects of the CPS-containing ointment according to the present invention and a commercially available moisturizing ointment, and Figure 3 is a graph comparing the moisturizing effects of the CPS-containing ointment according to the present invention and the commercially available moisturizing ointment. It is a graph comparing the moisturizing effect with a known ointment containing chondroitin sulfate.

Claims (1)

[Claims] 1. A skin moisturizer containing polysulfate of chondroitin sulfate as an active ingredient. 2. The agent is cosmetic soap, transparent soap, cleansing cream such as cleansing cream, creams such as cold cream, hand cream, vanishing cream, foundation cream, hormone cream, plant juice lotion, alkaline lotion, astringent lotion, etc. enlotsion, hand lotion,
The scope of the patent claims provides a dosage form for skin cosmetics selected from lotions such as emulsions, foundation lotions, and cleansing lotions, cosmetics such as powdered cosmetics, water supplements, and kneaded cosmetics, and lipsticks. The skin moisturizer according to item 1.