JPS60112708A - Humectant for skin - Google Patents

Abstract

PURPOSE:To provide a skin humectant having excellent property and useful as a cosmetic, by using a polysulfate of chondroitinsulfuric acid extracted from the organ of animal, as an active component. CONSTITUTION:The objective skin humectant contains 0.1-0.3% polysulfate of chondroitinsulfuric acid (CPS). The CPS-containing humectant has higher moisture-retaining effect than the known humectant, and is used in the form of soap, cream, face lotion, face powder, lipstick, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin moisturizer containing polysulfate ester of chondroitin sulfate extracted from animal organs as an active ingredient.

；I″Normal human skin has a moderate amount of sebum (Sebum).
is secreted, and the various triglycerides, waxes, cholesterol, squalene, paraffin hydrocarbons, and other components contained therein act as moisturizing ingredients to prevent the skin from becoming too dry and to keep it supple. ing. However, in the skin 1a, which is the skin of a person with rough skin or the skin of a person who frequently uses detergent, the skin becomes dry or rough due to a lack of sebum.

As mentioned above, when the natural moisturizing effect is insufficient,
Artificially supplying moisturizing substances to the skin to prevent the skin from drying out has been practiced for a long time.For example, for cosmetics, glycerin, propylene glycol, sorbitol, or diethylene glycol monoethyl ether (or monomethyl ether) has been used for a long time. It is well known that moisturizers such as ) are commonly included.

By the way, moisturizers applied to human skin have the following objectives:
-1 It is desirable to have the property of retaining moisture without emitting /N when the humidity in the air is low, and on the other hand not absorbing moisture beyond a certain limit even when the humidity is high. In other words, the ideal moisturizer is NaturalMoisturizin
Sodium pyrrolide/sodium carboxylate is a representative of G Factor (NMF: a metabolic product of keratinization or a highly hygroscopic substance derived from sweat as a physiological moisturizing ingredient on the skin surface).
na carboiylate (PCA-Na
)) should have a performance equivalent to or better than 1-. However, the known humectant described in "-" has the disadvantage that it tends to be sticky due to its excessive hygroscopicity.

In recent years, mucopolysaccharides have attracted attention as they have better moisturizing effects than the above-mentioned PCA, and various cosmetics containing chondroitin sulfate or hyaluronic acid, which belong to these mucopolysaccharides, have been studied, and some of them are Cosmetics containing it are commercially available.

As a result of intensive research into the moisturizing effect of chondroitin sulfate polysulfate (hereinafter abbreviated as CPS) extracted from animal organs, the present inventor found that this ester is far more effective as a humectant than the chondroitin sulfate and hyaluronic acid mentioned above. It was found that the results were excellent. As a heparinoid substance, CPS is known to have antithrombin effects, anticoagulant effects, and peripheral blood circulation promoting effects, but its moisturizing effect, especially its moisturizing effect in skin cosmetics, is unknown until now. This is what it was. In order to objectively measure the moisturizing effect, the present inventors investigated the water-containing pores in the stratum corneum of the skin.
Ohi, M., ,Twatsuki, Ni, ,Kana.
maru, Y.

Yamada M and Ichijo, B, :Ev
Aluation of theskin 5urfa
ce hydration in my ivo by el
electrical measurement, J, Tnv
est, Dermatol, 75. :500-50
The J11 measurement method (impedance meter method) based on high-frequency conduction, which was developed by J.D. 7 (1980), was adopted, and this measurement method was found to be in good agreement with the sensory observation results.

[Experiment method] Using an impedance meter, (la) 0.3%C
Comparison of the moisturizing effects of PS-containing soft string, (lb) 0.1% CPS-containing ointment, and (IC) base, and (2)
a) Contains 0.3% CPS;) Commercially available products that claim to have a moisturizing effect: A (main ingredient: urea), B (J: ingredient: soluble collagen), C (main ingredient: hyaluronic acid), and D
The moisturizing effect of (main ingredient: analogue of natural lfV component) was investigated under the following conditions.

Subjects: 5 second sons and 5 females How to apply: Two sites: inside of left and right forearms.

Surface JA - approx. 13cm', i, l -□ 50 pLl 1. Experiments (1a), (lb) and (Ic) (7) The results are shown in Table 1 and Figure 1. Experiments (2a), (2-A), (
The results of 2-B), (2-C) and (2-D) are shown in Table 2 and FIG.

(Left below) -1/beansme -ni 1・)1-b)O,I
% CPS content 1◆ (Pl2-8 Commercial product B (main component soluble collagen) As shown in Table 1 and Figure 1, 0.3% CPS content
In the ointment containing PS, a noticeable moisturizing effect was observed 30 minutes after application, and the effect continued even 6 hours after application. The ointment containing 0.1% CPS showed a higher moisturizing effect than the base after 4 hours, and even after 6 hours it showed a higher value than before application, indicating that it has a high moisturizing effect. Ta.

Ointments containing 0.3% CPS shown in Table 2 and Figure 2 and general commercial products (drugs and quasi-drugs) claiming moisturizing effects
In a comparison of the moisturizing effect with urea, Pharmaceutical A, which has urea as its main ingredient, showed a relatively high moisturizing effect immediately after application, but its moisturizing ability decreased over time, and 6 hours after application, it showed a higher moisturizing effect than before application. decreased to the value. Furthermore, quasi-drug B containing soluble collagen as a main component did not exhibit particularly large moisturizing effects except immediately after application. Furthermore, C (quasi-drug, ointment) containing hyaluronic acid as an active ingredient, contrary to expectations,
After a few minutes, the temperature decreased to the same level as before application. Mo and A,
Both B and C have almost no moisturizing effect after 6 hours. Finally, although the quasi-drug containing analogs of natural moisturizing ingredients showed relatively high values even 6 hours after application, its moisturizing effect was lower than that of the product of the present invention (containing CP 50.3%). It was inferior. From these experimental results, it is clear that the 8CPS-containing skin moisturizer according to the present invention has a better moisturizing effect than existing commercially available products.

The present invention is based on the above findings, and its gist is to utilize CPS as a skin moisturizer.

To achieve this objective, the skin moisturizer according to the present invention is preferably applied to cosmetic soaps, transparent soaps, or detergents such as cleansing creams, cold creams, hand creams, vanishing creams, foundation creams, hormonal creams (emollient creams), etc. Creams such as creams containing estrogen, plant juice liquefied water, alkaline lotions, astringent lotions, hand lotions, milky lotions, foundation lotions, cleansing lotions, and powders. It is applied to human skin in dosage forms such as Oshiroi, Mizu Oshiroi, and Ren Oshiroi, and lipstick. Raw materials for these preparations include animal and vegetable oils, animal and vegetable waxes,
Squalane, lanolin, microcrystalline wax, ceresin wax, paraffin wax, petrolatum, liquid paraffin, higher fatty acids, higher fatty alcohols, higher fatty esters, various surfactants, natural or semi-synthetic polysaccharides and their derivatives, glycerin, propylene glycol,
Known perfume ingredients are used, such as sorbitol, various fungicides or preservatives, antioxidants, various fragrances, fillers (excipients), and colorants. CPS is preferably present in the composition in an amount of 1 to 10%, preferably 0.1 to 03%.

Hereinafter, how to implement the invention will be explained using examples.
The examples are for illustrative purposes only and are not intended to limit the scope of the invention.

Example 1 (Hand cream) The following ingredients were heated to 70-75°C, stirred and boiled using a homomixer, cooled, and passed through a homogenizer if necessary to make it homogeneous. Product.

Formulation example 1 White petrolatum lo, og Setanol 10.0g Lanolin alcohol 5.0g Cholesterol 1.0g Glyceryl monostearate 10g Polyoxyethylene cetyl ether 1. Og CPS O, 3g °F (total 100.0g Prescription example 2 Liquid paraffin 30.0g Cetanol 3.0g Paraffin wax 5.0g Propylene glycol 5.0g Vryceryl monostearate 1-1.8g Polyoxyethylene monostearate 2.Og CPS O1Ig 'lv Total 100.0g Prescription example 3 White petrolatum 25.0g Stearyl alcohol 220g Propylene glycol 12.0g Sodium lauryl sulfate 1.5g Ethyl paraoxybenzoate 0.025g Propyl paraoxybenzoate O,O15gdPS O3g Example 2 (Hand lotion) The following ingredients are stirred and mixed using a homomixer to form a product.

Formulation example 4 Sorbitol 4.0g Citric acid 0.9g Ethanol 1O1O+sl Methylparaben %O, 1g CP5 0.3g 'Shokei 100.0g Formulation example 5 (same as above) Triethanolamine 0.2g 1.3-butylene gelicol 7. 0g ethanol 2
0, Osl Methylparaben 0.1g CP5 0.3g Total 100.0g

[Brief explanation of the drawing]

Figure 1 is a graph comparing the moisturizing effect of a CPS-containing ointment according to the present invention and a control CPS-free ointment, and Figure 2 is a graph comparing the moisturizing effect of a CPS-containing ointment according to the present invention and a reprint moisturizing ointment. It is. Figure 1-]0. 3 standard deviations above the mean Time (hr,) Fig. 2 9elo℃ Time (hr,)

Claims (1)

[Scope of Claims] A skin moisturizer containing a polysulfate ester of chondroitin sulfate as an active ingredient. [2] The skin moisturizer according to claim 1, wherein the agent is in the form of a skin cosmetic.