JP4088497B2 - Cosmetics - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a cosmetic containing cytokinin together with specific components. Furthermore, it is related with the beauty method formed by using together a specific component and cytokinin.
[0002]
[Prior art]
The skin barrier function is indispensable for protecting a living body from stimuli from the outside and maintaining a constant moisture in living tissues including the skin. Therefore, if the skin barrier function decreases due to external factors such as dryness or ultraviolet rays, internal factors such as various diseases and aging, etc., it becomes easy to cause inflammation from external stimuli and binds moisture to the skin. It becomes impossible and flexibility decreases. When the skin barrier function is lowered, atopic dermatitis, rough skin, dermatitis and the like are likely to occur. In normal skin, the absorption function that absorbs moisture and the retention function that binds and retains absorbed moisture work. However, in skin with a reduced skin barrier function, both absorption and retention functions decrease. Appears as an appearance change (dry skin disease), scales, texture, and wrinkles.
[0003]
In order to enhance the moisturizing effect, cosmetics often contain a moisturizing agent. Moisturizers are generally classified into water-soluble moisturizing ingredients and oil-based film-forming ingredients, and these ingredients can be used alone or in combination to form a film on the skin surface while forming a skin keratinous moisture content. Can be increased. However, since the improvement effect of the skin barrier function is not sufficient, the expected moisturizing effect could not be obtained.
[0004]
[Problems to be solved by the invention]
An object of this invention is to provide the cosmetics which are excellent in the improvement of a skin barrier function, and have a high moisturizing effect by extension.
[0005]
[Means for Solving the Problems]
As a result of intensive studies to solve the above problems, the present inventors have found that the skin barrier function is improved by containing both a specific component and cytokinin. Cytokinin has a common effect on plants, ie, growth regulation of each organ. And as a physiological effect on humans, the effect of cytokinin alone has a skin normalizing effect with kinetin to make dry skin, aged skin, so-called bulky skin, normal moist and moisturized skin ( Japanese Patent Laid-Open No. 4839646), Kinetin has a hair-growth effect (Japanese Patent Laid-Open No. 6-211632), and an amount of 6- (substituted amino) purine cytokinin that does not significantly change the growth rate and total proliferation ability of the skin It is known to improve the appearance (Japanese Patent Publication No. 10-510240). Further, the effect of combining cytokinin and other components is to promote the division of skin cells by blending kinetin and shikon (purple root) during cosmetic production (Japanese Patent Laid-Open No. 60-19709). ) Etc. were known. However, the relationship between cytokinin and skin barrier function was not known.
[0006]
The present invention has been developed based on such knowledge. That is, the present invention is a cosmetic listed in the following (1) to (2):
(1) Cosmetics containing cytokinin, at least one selected from the group consisting of allantoin, allantoin derivatives, aloe extract, glucosamine, glucosamine derivatives and pharmacologically acceptable salts thereof,
(2) The cosmetic according to (1), further comprising at least one selected from the group consisting of a moisturizing component, an anti-aging component, an antioxidant component, an anti-inflammatory component, and a film-forming component,
Furthermore, the present invention is a cosmetic method listed in the following (3):
(3) A cosmetic method comprising a combination of cytokinin and at least one selected from the group consisting of allantoin, allantoin derivatives, aloe extract, glucosamine, glucosamine derivatives and pharmacologically acceptable salts thereof.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
Cytokinin used in the present invention is a plant hormone represented by kinetin or a derivative thereof, and is a substance that exhibits at least one of a cell division promoting action or a redifferentiation promoting action in plant or plant tissue culture like kinetin. Say. Cytokinin is a general term for substances having the same action as kinetin (6-furfurylaminopurine), a physiologically active substance isolated from a DNA degradation product as a substance that promotes cell growth in plant tissue culture. Many cytokinins such as derivatives (such as kinetin) and urea derivatives are known.
[0008]
Specifically, the cytokinins used in the present invention are 6-furfurylaminopurine (also known as kinetin), 6-benzylaminopurine, 6- (4-hydroxy-3-methyl-trans-2-butynylamino) purine (also known as Zeatin), 6- (3-methyl-2-butenylamino) purine, 6- (4-hydroxy-3-methylbutylamino) purine (also known as dihydrozeatin), 6- (4-hydroxy-3-methyl-trans- 2-butenylamino) -9-β-D-ribofuranosylpurine (also known as ribosyltranszeatin), 6-methylaminopurine, 6-n-propylaminopurine, purine cytokinins such as benzoylamino-1-deazapurine; N , N′-diphenylurea, N-phenyl-N ′-(4-pyridyl) urea and other urea-based cytokinins; Such derivatives kinetin such Jill kinetin and the like.
[0009]
Of these, purine cytokinins are preferable, and 6-furfurylaminopurine (also known as kinetin) is particularly preferable. In addition, said cytokinin can be used individually by 1 type, or can also be used in combination of 2 or more types arbitrarily.
[0010]
The content of cytokinin blended in the cosmetic of the present invention varies depending on the type of compound, dosage form, etc., but is usually 0.001 to 3.0% by weight, preferably 0.001 to 1.0% by weight, More preferably, the range of 0.001-0.5 weight% can be mentioned.
[0011]
Allantoin, allantoin derivatives, or salts thereof used in the cosmetic of the present invention are components that are known to have anti-inflammatory effects. As an allantoin derivative mix | blended in the cosmetics of this invention, allantoin glycyrrhetin, allanto chlorohydroxy aluminum, etc. are mentioned, for example. The content of allantoin or allantoin derivative blended in the cosmetic of the present invention varies depending on the type of compound, dosage form, etc., but is usually 0.001 to 5.0% by weight, preferably 0.001 to 3.0. A range of 0.01% to 0.5% by weight can be mentioned.
[0012]
The glucosamine, glucosamine derivative or pharmaceutically acceptable salt thereof in the present invention is preferably a natural product purified from an animal, a plant, a microbial cell, a culture solution, or the like, but is chemically synthesized by a known method. The obtained synthetic product may be used, or a commercial product may be used. In the present invention, the glucosamine derivative is preferably a compound that can be converted into glucosamine after being applied in vivo, and examples thereof include derivatives such as N-acetylglucosamine. The glucosamine derivative is not particularly limited as long as it exhibits the effects of the present invention.
[0013]
As the glucosamine or glucosamine derivative salt of the present invention, a pharmacologically (pharmaceutically) or physiologically acceptable salt can be used. Examples of pharmacologically or physiologically acceptable salts include organic acid salts (for example, lactate, acetate, butyric acid, trifluoroacetate, fumarate, maleate, tartrate, citrate, succinate, etc. Acid salt, malonate, methanesulfonate, toluenesulfonate, tosylate, palmitic acid, stearic acid, etc., inorganic acid salt (eg hydrochloride, sulfate, nitrate, hydrobromide, phosphorus Acid salts) and the like. Preferred are glucosamine hydrochloride and glucosamine sulfate. Particularly preferred is glucosamine hydrochloride.
In addition, you may use these glucosamine, its derivative (s), or those salts individually or in combination of 2 or more types.
[0014]
In the cosmetic of the present invention, the content of glucosamine, a glucosamine derivative or a salt thereof varies depending on the type and dosage form of glucosamine, but is usually 0.00001 to 70.0% by weight, preferably 0.001 to 50% by weight. %, More preferably 0.001 to 20% by weight, particularly preferably 0.01 to 10% by weight.
[0015]
The aloe extract used in the cosmetic of the present invention is a plant belonging to the Aloe family of liliaceae (Aloe
ferox, Aloe spicata, Aloe barbadensis, Aloe arborescens, Aloe
africana etc.), and the extracts of aloe leaves, etc., which are raw materials, have been known for their anti-inflammatory, moisturizing and whitening effects and have long been used for safety in pharmaceuticals and cosmetics. High extract. Aloe contains different components depending on its type and production area, but can be used without particular limitation in the extract used in the present invention.
The extraction method of the aloe extract is not particularly limited, but the leaves are mainly used as the raw material, and the leaves are subjected to appropriate treatment such as drying, chopping, pressing, etc., or the leaves as they are at low temperature or warming. The method of extracting with a solvent can be illustrated below. The obtained extract can be purified by filtration or ion exchange resin purification, adsorption or the like, and can be used as a paste, gel, powder or liquid. Moreover, aloe extracts, such as a commercially available aloe extract, can also be utilized.
[0016]
Examples of the extraction solvent that can be used for the extraction of aloe include water, lower alcohols (such as methyl alcohol, ethyl alcohol, propanol, butanol, and butanol), polyhydric alcohols (such as glycerin and 1,3-butylene glycol), and the like. It is done.
[0017]
In the cosmetic of the present invention, the content of the aloe extract is preferably 0.00001 to 10% by mass, more preferably 0.0001 to 5% by mass, and particularly preferably as the dry solid content of the aloe extract. 0.0001 to 1% by mass. When an extract such as aloe extract is used, the extract such as aloe extract is preferably 0.001 to 20% by mass, more preferably 0.001 to 10% by weight, and particularly preferably 0. 0.01 to 10% by weight.
[0018]
The specific components described above of the present invention may be used in pharmacologically (pharmaceutically) or physiologically acceptable salts. Examples of pharmacologically or physiologically acceptable salts include organic acid salts (for example, lactate, acetate, butyric acid, trifluoroacetate, fumarate, maleate, tartrate, citrate, succinate, etc. Acid salt, malonate, methanesulfonate, toluenesulfonate, tosylate, palmitic acid, stearic acid, etc., inorganic acid salt (eg hydrochloride, sulfate, nitrate, hydrobromide, phosphorus Acid salts) and the like. Moreover, you may use a hydrate for the above-mentioned specific component of this invention.
[0019]
The cosmetic of the present invention is further selected from the group consisting of a moisturizing component, an anti-aging component, an antioxidant component, an anti-inflammatory component and a film-forming component for the purpose of further enhancing the skin barrier function improving effect and the moisturizing effect. It can mix | blend at least 1 type or in combination of 2 or more types. These components are not particularly limited as long as they are conventionally used in the pharmaceutical, quasi-drug, or cosmetic field, and are used in the future, and can be arbitrarily used.
[0020]
As moisturizing ingredients, amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, theanine, and derivatives thereof; peptides such as collagen, collagen peptide, gelatin; glycerin, 1,3-butylene glycol, di Polyhydric alcohols such as propylene glycol and polyethylene glycol; Sugar alcohols such as sorbitol; Phospholipids such as lecithin and hydrogenated lecithin; Mucopolysaccharides such as propylene glycol, heparin, chondroitin and hyaluronic acid; Polysaccharides such as pectin; NMF-derived components such as sodium pyrrolidonecarboxylate and urea; plant components such as carrot, alfalfa, akebi, altea, arnica, fennel, witch hazel (hamamelis), turmeric, Koganebana (Ogon), yellowfin (Hakubaku), hypericum, rice (Rice), chamomile, licorice, Chinese mugwort (Inchinkou), Kiwi, Clara (Kuzin), grape, gardenia, Confrey (Hariharisou), savonso, cactus, hawthorn , Perilla, peonies, birch, Japanese horsetail, bodyfish, salvia (sage), sea bream, nematode, mulberry (sowbowl), soybean, ginger (thyme), sugar beet, pearl millet, jujube, elderberry, parsley, pearl barley (yokuinin) ), Butchiya's Bloom, Loofah, Hop, Maronie, Mulberry, Melissa, Peach, Yukinoshita, Raspberry, Lavender, Astragalus, Rose, Neubara (Ages), Rosemary (Mannenrou), Licorice, Cha (Ryokucha, Ucha, Oolongcha), lily, barley (malt root), wheat, apricot, oats, corn, lemon, orange, strawberry, safflower, gentiana, gentian (ryutan), mint, green lily (spearmint), yellow mint Peppermint), Mukuroji, Eucalyptus, Kumazasa, Odorikosou, Waremokkou (Jiuyu), Avocado, Seaweed (Brown algae such as Kombu; Red algae such as Amanita; Green algae such as Aonori; Those containing cyanobacteria such as Spirulina), grapefruit and prune Ingredients derived from plants such as lime, gentian pepper, tormentilla, yuzu (kijitsu), auren, button (button pi), olive, sunflower (safflower), jojoba, macadamia nut, medhome, almond, sesame, boge (borage) Kiss or essential oils, and the like. These moisturizing components may be used alone or in combination of two or more.
Among these, hydroxyproline, glycine, alanine, serine, collagen peptide, glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, lecithin, hydrogenated lecithin, propylene glycol hyaluronate, heparin, chondroitin, lactic acid, pyrrolidone Sodium carboxylate, urea, plant components include carrots, akebi, alfalfa, witch hazel (hamamelis), rice (rice), chamomile, licorice, grapes, gardenia, comfrey (spotted spinach), elephant, perilla, salvia (sage), Assembly, Senkyu, Mulberry, Soybean, Tachikaku Sou (Time), Toki, Tokinsenka, Barley (Yokuinin), Butchiya's Bloom, Loofah, Maronier, Marveli , Melissa, Peach, Yukinoshita, Lavender, Rose, Neubara (Ages), Rosemary (Mannenrou), Licorice, Cha (Ryokucha, Kocha, Oolongcha), Lily, Barley (Mort Root), Wheat, Apricot (Kyonin), Murasaki (Sicon), lemon, orange, mint, green mint (spearmint), mint mint (peppermint), mugwort, eucalyptus, bitumen (jiu), avocado, seaweed, grapefruit, lime, citrus, lauren, olive, borage ( Borage), sunflower (safflower), jojoba, macadamia nut, medhome, sesame-derived ingredients, extracts and essential oils.
[0021]
When the moisturizing component is further used, the content of the cosmetic is preferably 0.001 to 50% by weight, more preferably 0.01 to 20% by weight, particularly preferably 0.01 to 10% by weight. It is a range.
[0022]
Anti-aging components include amino acids such as glycine, proline, hydroxyproline, leucine, alanine, γ-aminobutyric acid, and ε-aminoproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid; glycolic acid, Hydroxyl acids such as lactic acid and salicylic acid; tannin, flavonoid, saponin, photosensitizer No. 301, plant components are Arnica, Ginkgo, fennel, Enmezo, Dutch oak, chamomile, licorice, Roman chamomile, carrot, gentian, rice, hawthorn Hawthorn, Apricot, Senkyu, Assembly, Thyme, Clove, Chinpi, Toki, Tonin, Spruce, Carrot, Butcher Bloom, Grapes, Button, Maronier, Melissa, Yuzu, Yokuinin, Rosemary, Lo Zuhippu, citrus unshiu peel, angelica, spruce, peaches, apricots, walnuts, etc. from which the component maize, and the like extract or essential oil. These anti-aging components may be used alone or in combination of two or more.
Among them, preferably, amino acids such as hydroxyproline, alanine, glycine, γ-aminobutyric acid, and ε-aminoproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids; saponin, chamomile as a plant component, Licorice, Roman Chamomile, Carrot, Rice, Assembly, Thyme, Clove, Chinpi, Toki, Tonin, Spruce, Carrot, Butcher Bloom, Grape, Maronier, Melissa, Yokuinin, Rosemary, Rosehip, Chimpi, Toki, Spruce, Peach Derived components, extracts and essential oils.
[0023]
When using an anti-aging component, as content with respect to the cosmetics, Preferably it is 0.001 to 10 weight%, More preferably, it is 0.01 to 5 weight%.
[0024]
Antioxidant components include tocopherol derivatives such as tocopherol and tocotrienol, butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, erythorbic acid and salts thereof, astaxanthin, tea extract, flavonoids, glutathione peroxidase, glutathione-S-transferase, Catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, hypotaurine, and plant components such as armchair, turmeric, ages, etinashi, green grass, hypericum, gobishi, gentian pepper, rice, rice bran, comfrey, perilla, peonies, peonies, peonies Soybean, natto, tea, clove, loquat, buttons, marronnier, yukinoshita, rooibos, and rosemary Rurina, chlorella, components derived from plants such as Dunaliella, like extracts or essential oils. One or two or more of these antioxidant components may be used.
Among these, tocopherols, tocopherol derivatives, thiotaurine, hypotaurine, thioredoxin, astaxanthin, flavonoids, components derived from tea, rosemary, extracts and essential oils as plant components are preferable.
[0025]
When using an antioxidant component, the content of the cosmetic is usually 0.0001 to 10% by weight, preferably 0.0001 to 5% by weight, more preferably 0.001 to 5% by weight.
[0026]
Anti-inflammatory components include glycyrrhizic acid such as monoammonium glycyrrhizinate, stearyl glycyrrhizinate, dipotassium glycyrrhizinate and derivatives thereof; glycyrrhetinic acid derivatives such as glycyrrhetinic acid and stearyl glycyrrhetinate and salts thereof; ε-aminocaproic acid Guaiazulene; hydrocortisone; plant components such as chamomile, mugwort, comfrey, shikon, perilla, sage, thyme, eucalyptus, carrot, carrot, butcher bloom, maronier, peach, rosemary, etc. Can be mentioned. One or more of these anti-inflammatory components may be used.
Among them, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhizinate, stearyl glycyrrhetinate, stearyl glycyrrhetinate; plant components such as chamomile, comfrey, sage, calendula, carrot, peach, maronier, rosemary , Extracts and essential oils.
[0027]
When using an anti-inflammatory component, the content with respect to the cosmetic is usually 0.0001 to 10% by weight, preferably 0.0001 to 5% by weight, more preferably 0.001 to 3% by weight.
[0028]
As film-forming components, hydrocarbon oils such as petrolatum, paraffin and squalane; perfluoropolyethers such as FOMBLIN (trade name of Ausimont); silicone oils such as cross-linked methylpolysiloxane; alginic acid, pullulan, albumin, karaya gum, Examples thereof include water-soluble polymers such as polyvinyl alcohol. These film forming components may be used alone or in any combination of two or more.
[0029]
Furthermore, when using a film-forming component, the barrier function improving effect is further promoted by blocking physical stimulation from the outside to the skin by forming a film on the skin. The content is usually 0.001 to 50% by weight, preferably 0.001 to 30% by weight, more preferably 0.001 to 20% by weight, and particularly preferably 0.01 to 20% by weight.
[0030]
In the cosmetic of the present invention, at least one selected from surfactant components can be further blended with the above-described components.
Examples of the surfactant component include POE-branched alkyl ethers such as polyoxyethylene (hereinafter referred to as POE) -octyldodecyl alcohol and POE-2-decyltetradecyl alcohol; POEs such as POE-oleyl alcohol ether and POE-cetyl alcohol ether -Alkyl ethers; sorbitan esters such as sorbitan monooleate, sorbitan monoisostearate and sorbitan monolaurate; POE- such as POE-sorbitan monooleate, POE-sorbitan monoisostearate, and POE-sorbitan monolaurate Sorbitan ester; glycerol fatty acid ester such as glycerol monooleate, glycerol monostearate, and glycerol monomyristate; POE-glycerol monooleate, PO POE-glycerin fatty acid esters such as glycerin monostearate and POE-glycerin monomyristate; POE-cured castor oil fatty acids such as POE-dihydrocholesterol ester, POE-cured castor oil, and POE-cured castor oil isostearate Esters; POE-alkyl aryl ethers such as POE-octylphenyl ether; glycerin alkyl ethers such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; POE-glycerin alkyls such as POE-monostearyl glyceryl ether and POE-monomyristyl glyceryl ether Ethers; diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl decaisostearate, and diglyceryl diisos Various nonionic surfactants such as polyglycerol fatty acid esters such as allate :: potassium, sodium, diethanolamine, triethanolamine of higher fatty acids such as myristic acid, stearic acid, palmitic acid, behenic acid, isostearic acid, and oleic acid Various salts such as amino acids; potassium or sodium salts of ether carboxylic acids; salts of N-acyl amino acids; N-acyl sarconates; anionic surfactants such as higher alkyl sulfonates; alkylamine salts, polyamines, amino acids Examples thereof include cationic surfactants such as alcohol fatty acid organic silicone resins and alkyl quaternary ammonium salts; amphoteric surfactants such as imidazolium betaine derivatives; naturally derived surfactants such as saponins. These surfactants may be used alone or in any combination of two or more.
[0031]
When using a surface active ingredient, the cytokinin that does not affect the skin and mucous membranes and has the effect of the present invention is more stably maintained in the preparation. As a result, the cosmetic of the present invention has a higher effect. Since it can be exhibited, the content in the cosmetic can be appropriately selected and used within a range of 0.01 to 50% by weight in the cosmetic. The range is preferably 0.1 to 40% by weight, more preferably 0.5 to 20% by weight.
[0032]
The cosmetics of the present invention include pharmaceuticals and pharmaceutical parts as needed in addition to the above-mentioned components within the quantitative and qualitative ranges that do not impair the quality such as appearance stability and viscosity and do not impair the effects of the present invention. Various components generally used as components of external preparations in the field of external products or cosmetics, such as bases, emulsifiers, stabilizers, irritation reducers, thickeners, preservatives, colorants, dispersants, pH adjusters Perfumes and the like can be blended. In addition, as each of these components, it is possible to use components that are conventionally used in the pharmaceutical, quasi-drug, or cosmetic field, and that will be used in the future. These components may be used alone or in combination of two or more. Can be combined in any combination.
[0033]
The cosmetic of the present invention contains a paste, a mousse, a gel, a liquid, an emulsion, a cream, a sheet, an aerosol, and a spray by blending a solvent and a base for commonly used external preparations. Can be prepared in various desired forms. In addition, the components used in the present invention may be blended as they are, or may be blended in a preparation after being encapsulated in a functional body that promotes penetration and absorption into the skin such as liposomes and microspheres. Good. And these can be manufactured by the normal method of this industry.
[0034]
The cosmetic of the present invention is usually required to have a liquidity of pH 2 to 8, but preferably from pH 3 to 7, more preferably pH 3 from the viewpoint of low irritation to the skin and mucous membrane and good skin feeling. It is desirable that the acidity is 5 to 6 weakly acidic to neutral.
[0035]
The cosmetics of the present invention include, for example, makeup cosmetics such as foundations and lipsticks; basic cosmetics such as lotions, cosmetic liquids, emulsions, creams, lotions, oils, gels and packs; acne treatment agents, whitening agents, UV protection Various cosmetics belonging to the field of medicinal cosmetics, topical medicines, or external quasi-drugs such as agents can be obtained.
[0036]
Furthermore, the present invention provides a cosmetic method comprising a combination of cytokinin and at least one selected from the group consisting of allantoin, allantoin derivatives, aloe extract, glucosamine, glucosamine derivatives and pharmacologically acceptable salts thereof. Is also provided.
[0037]
Examples of the allantoin, allantoin derivative, aloe extract, glucosamine, glucosamine derivative and salts thereof, cytokinin, and contents and types of these components used in the cosmetic method of the present invention can be mentioned above. .
[0038]
In the cosmetic method of the present invention, in the cosmetic method of the present invention, allantoin, allantoin derivative, aloe extract, glucosamine, glucosamine derivative and pharmacologically acceptable salt thereof and cytokinin are temporally mixed. The effect of the present invention can also be exhibited by applying to the skin at the same time.
[0039]
【The invention's effect】
By combining cytokinin with specific components, an excellent skin barrier function improving effect is exhibited. The cosmetic of the present invention is a cosmetic with improved skin barrier function, high moisturizing effect and excellent skin beautifying effect. Furthermore, skin homeostasis maintenance effect, anti-aging effect, inflammation prevention effect, etc. are expected. The cosmetics of the present invention are used as cosmetics intended to improve rough skin, moisturize, beautiful skin, anti-aging, anti-wrinkle, whitening, etc., for example, emulsions, creams, lotions, packs, cleaning products, makeup cosmetics, etc. be able to.
[0040]
【Example】
Hereinafter, the present invention will be described in more detail based on examples and test examples, but the present invention is not limited to these examples. In the following formulations,% means weight (W / W)% unless otherwise specified.
[0041]
Test example Sample preparation
Preparation of Example 1: Purified water 83.09 g, kinetin 0.01 g, glucosamine hydrochloride (Yaizui Suisan Co., Ltd., glucosamine hydrochloride) 0.10 g, aloe extract (Ichimaru Falcos Co., Ltd., trade name “Aloe Vera Liquid BG”) 0.2 g Allantoin 0.2 g, stearyl glycyrrhetinate 0.10 g, 1,3-butylene glycol 5.0 g, tocopherol acetate 0.1 g, behenyl alcohol 0.25 g, cetyl 2-ethylhexanoate 6.0 g, sorbitan monostearate 1.2 g, palmitic acid 1.0 g, 100 g of cream consisting of 1.0 g of cholesteryl stearate, 0.3 g of stearic acid, 0.6 g of polyoxyethylene sorbitan monostearate, 0.45 g of triethanolamine and 0.4 g of carboxyvinyl polymer was obtained.
Preparation of Comparative Example 1: Purified water 74.55 g, kinetin 0.05 g, squalane 5.50 g, paraffin 1.25 g, 1,3-butylene glycol 6.0 g, concentrated glycerin (Japanese Pharmacopoeia) 1.0 g, hydrogenated soybean phospholipid 0.50 g, From methyl polysiloxane 0.50 g, isostearyl alcohol 4.0 g, glyceryl stearate 3.0 g, cetanol 1.25 g, polyoxyethylene polyoxypropylene cetyl ether 1.20 g, polyoxyethylene behenyl ether 1.0 g, hydroxyethyl cellulose 0.10 g, xanthan gum 0.10 g 100 g of cream was obtained.
[0042]
Test Example 1 Measurement of transepidermal water loss
HOS: HR-1 hairless mice were used for testing after a habituation period. The breeding conditions in the animal room were room temperature 23 ± 2 ° C., humidity 55 ± 15%, ventilation frequency 15 times / hour, and lighting time 12 hours (7: 00-19: 00) per day. During the test period, chow and water were ad libitum.
HOS: HR-1 hairless mice (6 weeks old female) are divided into 3 groups of 5 per group, 50 μl of oleic acid (Tokyo Kasei Co., Ltd.) is applied to the dorsal site, and UVB is 200 mJ / cm 2 immediately after application. Irradiated. After 4 hours of irradiation, 50 μl of oleic acid was applied again, and UVB was irradiated at 200 mJ / cm 2 immediately after the application. In this way, a skin model in which the barrier was broken by two times of ultraviolet irradiation was created. 24 hours after the first UVB irradiation, 50 μl of the cream of Example 1 was applied to the first group, 50 μl of the cream of Comparative Example 1 was applied to the second group, and the third group was uncoated. The mice of group 1 to group 3 measured the amount of transepidermal water loss immediately after application of Example 1 or Comparative Example 1 (0 hours), 2 hours and 6 hours after application, The change rate (transepidermal water loss change rate = transepidermal water loss after 2 or 6 hours in each group / transepidermal water loss at 0 hours in each group) was calculated as a reference. Transepidermal water loss was measured using a transepidermal water loss measuring device (“2-channel moisture transpiration monitor AS-TW2” manufactured by Skinos Co., Ltd.) in an environment of 25 ° C. and relative humidity of 40%. Went. The results are shown in FIG.
[0043]
From the result of the test shown in FIG. 1, the group which applied the comparative example 1 which mix | blended combining squalane and paraffin which is a coating formation component and 1,3-butylene glycol, glycerin, and hydrogenated soybean phospholipid which are moisture retention components with kinetin. However, the transepidermal water loss was almost the same as in the case of no application, and the improvement of the barrier function was not recognized. On the other hand, in Example 1 in which glucosamine hydrochloride, aloe extract and allantoin were blended together with kinetin, a decrease in transepidermal water loss was observed, confirming the improvement effect of the skin barrier function. Therefore, the cosmetic of the present invention has an excellent skin barrier function improving effect, has a high moisturizing effect, imparts a texture, gloss and firmness to the skin, and is suggested to be an excellent cosmetic for keeping the skin beautiful. It was done.
[0044]
Example 2 Lotion
Kinetin 0.01%
Glucosamine hydrochloride 0.20%
Allantoin 0.50%
Polysorbate 60 0.30%
Diglycerin 7.50%
Sodium hyaluronate 0.20%
Sodium lactate 0.50%
Hydrolyzed collagen 0.20%
Polyethylene glycol 400 4.00%
Ethylenediaminetetraacetic acid disodium dihydrate 0.05%
Methylparaben 0.08%
Propylparaben 0.02%
Purified water
Total 100%
[0045]
Example 3 Gel
Kinetin 0.05%
Glucosamine hydrochloride 0.20%
Glycyrrhetinic acid 0.20%
Polyoxyethylene (60) hydrogenated castor oil 4.00%
Light liquid paraffin 2.00%
Squalane 0.50%
Isostearic acid 0.20%
Sodium hyaluronate 0.05%
Sodium lactate 0.50%
Carboxyvinyl polymer 0.10%
Carrageenan 0.20%
Ethylenediaminetetraacetic acid disodium dihydrate 0.05%
Phenoxyethanol 0.10%
Methylparaben 0.08%
Propylparaben 0.02%
Purified water
Total 100%
[0046]
Example 4 Cream
Kinetin 0.02%
Glucosamine hydrochloride 0.10%
Allantoin 0.20%
Pentaglyceryl diisostearate 1.00%
Glycerol monostearate 0.70%
Lactic acid myristyl 1.00%
Octyldodecyl myristate 3.00%
Cetanol 0.75%
Dipropylene glycol 3.00%
Diglycerin 1.00%
Olive squalane 1.50%
Safflower oil 2.50%
Carboxyvinyl polymer 0.25%
Chitosan 0.02%
Carrot extract 0.10%
Sodium hyaluronate 0.05%
Candelilla wax 0.50%
Hydrogenated soybean phospholipid 0.50%
Methylparaben 0.15%
Butylparaben 0.05%
Purified water
Total 100%
[0047]
Example 5 Latex
Kinetin 0.01%
Glucosamine hydrochloride 0.20%
Aloe extract 1.00%
(Product name "Aloe Vera Liquid BG" manufactured by Ichimaru Falcos)
Licorice flavonoid 0.05%
Stearyl glycyrrhetinate 0.10%
Squalane 4.00%
Hexyldecyl isostearate 5.00%
Isostearyl alcohol 2.00%
Batyl alcohol 0.50%
Dimethicone 0.50%
Concentrated glycerin (Japanese Pharmacopoeia) 2.00%
1,2-pentanediol 4.00%
Polyglyceryl-10 laurate-10 1.20%
Sorbitan stearate 0.30%
Carboxyvinyl polymer 0.10%
Xanthan gum 0.05%
Triethanolamine 0.15%
Phenoxyethanol 0.20%
Methylparaben 0.08%
Propylparaben 0.02%
Purified water
Total 100%
[0048]
Example 6 Cosmetic liquid
Kinetin 0.01%
Glucosamine hydrochloride 0.25%
Allantoin 0.30%
Aloe extract 2.00%
(Product name "Aloe Vera Liquid BG" manufactured by Ichimaru Falcos)
Seaweed extract 1.00%
Sorbitol 0.20%
Dipropylene glycol 8.00%
Concentrated glycerin (Japanese Pharmacopoeia) 5.00%
Diglycerin 5.00%
Jojoba oil 0.50%
Polyoxyethylene hydrogenated castor oil 0.50%
Xanthan gum 0.05%
Carboxyvinyl polymer 0.02%
Arginine 0.35%
Hydroproline 0.25%
Phenoxyethanol 0.20%
Methylparaben 0.15%
Butylparaben 0.05%
Purified water
Total 100%
[0049]
Example 7 Cream
Glucosamine hydrochloride 0.10%
Kinetin 0.01%
Cetyl 2-ethylhexanoate 10.00%
Dipropylene glycol 6.00%
Sorbitan monostearate 1.50%
Palmitic acid 1.00%
Cholesteryl stearate 1.50%
Polyoxyethylene sorbitan monostearate (20E.O) 0.70%
Triethanolamine 0.50%
Carboxyvinyl polymer 0.45%
Behenyl alcohol 0.50%
Aloe extract 0.10%
Allantoin 0.10%
Tocopherol acetate 0.10%
Stearyl glycyrrhetinate 0.10%
Ethylenediaminetetraacetic acid disodium dihydrate 0.05%
Methylparaben 0.15%
Butylparaben 0.05%
Perfume 0.02%
Purified water remaining
Total 100%
[0050]
Example 8 Lotion
Kinetin 0.05%
Allantoin 1.00%
Glycerin 5.00%
1,3-butylene glycol 1.00%
Polyoxyethylene behenyl ether 2.00%
Glyceryl stearate 2.00%
Paraffin 1.00%
Cetanol 1.00%
Hydrogenated lecithin 0.50%
Squalane 5.00%
Xanthan gum 0.05%
Hydroxyethyl cellulose 0.20%
Methylparaben 0.15%
Butylparaben 0.05%
Purified water
Total 100%
[0051]
Example 9 Cream
Kinetin 0.1%
Aloe extract 0.5%
(Product name "Aloe Vera Liquid BG" manufactured by Ichimaru Falcos)
L-ascorbyl magnesium phosphate 3.0%
Tocopherol acetate 0.01%
Dextrin palmitate 0.1%
Glyceryl stearate 1.0%
Polyoxyethylene stearyl ether 2.5%
Propylene glycol hyaluronate 0.05%
Petrolatum 2.0%
Beeslow 1.0%
Cetanol 1.5%
Paraffin 2.0%
Isopropyl myristate 2.0%
l-Menthol 0.1%
Carboxyvinyl polymer 0.2%
Triethanolamine 0.15%
Methylparaben 0.15%
Butylparaben 0.05%
Purified water
Total 100%
[0052]
[Brief description of the drawings]
1 is a graph showing the results of measuring the rate of change of transepidermal water loss in Test Example 1. FIG.

Claims (4)

A cosmetic comprising at least one selected from the group consisting of glucosamine, glucosamine derivatives, and pharmacologically acceptable salts thereof, and cytokinin. 2. The cosmetic according to claim 1, further comprising at least one selected from the group consisting of allantoin, allantoin derivatives, and pharmacologically acceptable salts thereof. Beauty aiming at a skin-beautifying effect in which at least one selected from the group consisting of glucosamine, glucosamine derivatives and pharmacologically acceptable salts thereof and cytokinin are applied to the skin in tandem or simultaneously. Method. At least selected from the group consisting of glucosamine, glucosamine derivatives and pharmacologically acceptable salts thereof. 1 A combined cosmetic intended for beautifying skin, comprising a cosmetic containing seeds and a cosmetic containing cytokinin.

Images