KR101419588B1 - Composition for Moisturizing Skin Comprising Ginseng Oil as Active Ingredient - Google Patents

Abstract

The present invention relates to a skin moisturizing composition containing red ginseng oil as an active ingredient. The red ginseng oil, which is a fat-soluble ingredient isolated from red ginseng or red ginseng, is excellent in skin moisturizing effect by improving skin moisture retention, Lt; / RTI >

Description

TECHNICAL FIELD The present invention relates to a skin moisturizing composition containing red ginseng oil as an active ingredient,

The present invention relates to a skin moisturizing composition containing red ginseng oil as an active ingredient.

Skin protects the organs in the body from changes in temperature and humidity, and from external stimuli such as ultraviolet rays. In particular, the skin carries about 65 ~ 70% of the moisture of the human body, that is, the physiologically active substance necessary for the human body, and helps the skin to maintain the smooth and moist condition. . However, the continuous physical and chemical stimuli received from the outside deteriorate the skin function and accelerate the aging of the skin. The aging of the skin also involves deterioration of the skin constituents as a whole, and as a result, the skin is easily split. In other words, it is possible to control anthropic temperature of cold / heating according to change of environment or life pattern, skin stress due to various stresses and environmental pollution generated in social life, frequent cleansing due to makeup habit, The moisture of the stratum corneum is decreased, the skin becomes dry, the surface becomes rough, and the skin appears to be dull and dull. Therefore, the need for a skin moisturizer is increasing.

Conventionally, polyhydric alcohols, water-soluble polymers, organic acid salts and the like are used as moisturizing agents contained in cosmetics. Occlusive ingredients and water-absorbing properties that prevent oil from evaporating on the surface of the skin, And a method of increasing moisture retention in the stratum corneum by using humectant (humectant) is widely used. As the humectant, polyols such as glycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol are used. As the sealing component, lipid components such as ceramides, essential fatty acids and lipid complexes are used. However, the hummocktite has a disadvantage in that it tends to be sticky due to intrinsic viscosity and physical properties of the polyol when it is applied to the skin, and the hermitants have a disadvantage of disturbing the stability of the emulsified interfacial membrane structure in the emulsified formulations And is unsuitable for producing transparent gel-like products. In addition, the formulations containing the lamellar liquid crystals, which have been under widespread research until recently, are known to have excellent moisture retention due to their similarity to the keratinous structure, but they are only available in a specific composition of the raw materials and thus have a problem in universal use.

Therefore, in recent years, the development of cosmetics for enhancing the moisturizing power has been actively promoted by introducing a naturally derived physiologically active substance obtained from animals, plants, microorganisms, etc. into cosmetics to maintain the inherent defensive function of the skin itself. However, most of these cosmetic compositions have problems such as insufficient effects, a risk of side effects due to a large amount or long-term use, and poor stability. On the other hand, it is known that red ginseng has a saponin component and a non-saponin component. The saponin component has been found to have anti-aging and anti-aging properties such as wrinkle and elasticity improvement. However, Studies on skin efficacy have not yet been done. Therefore, in the red ginseng containing physiologically active substances, there is a need to develop a skin moisturizing substance having few side effects among non-saponin ingredients which have not been reported on the skin improvement effect (JP-A No. 10-2009-0080234; Japanese Patent Application Laid-Open No. 10-2011-0108735).

It is an object of the present invention to provide a skin moisturizing composition containing red ginseng oil as an active ingredient.

To achieve the above object, the present invention provides a cosmetic composition for moisturizing skin containing red ginseng oil as an active ingredient.

As used herein, the term "skin" refers to a tissue covering the body surface of a human body, and is the broadest concept that includes not only the face or body but also scalp and hair.

In a preferred embodiment of the present invention, the red ginseng is preferably pale yellow-brown or light reddish brown ginseng which is steamed and dried without extracting the skin of the fresh ginseng, preferably 6-year old ginseng. Red ginseng is produced by a special processing technology, and it can be used in various processes such as anti-cancer component (ginsenoside Rh2), cancer cell toxin activity inhibition component (panaxatriol), platelet aggregation inhibiting component (maltol) Physiologically active ingredients are produced and contain trace amounts of essential oils.

The red ginseng oil of the present invention can be extracted from red ginseng powder or red ginseng powder. The red ginseng may be any one produced through a conventional process. The red ginseng powder may be obtained by extracting the extract from red ginseng, washing the obtained red ginseng with water, and then drying it with hot air to obtain a powder.

The red ginseng oil may be extracted by a conventional method such as room temperature extraction, warming extraction, ultrasonic extraction, supercritical extraction, or the like, and a nonpolar solvent may be used to effectively extract lipid soluble components from red ginseng. As the nonpolar solvent, hexane, chloroform, dichloromethane, ethyl acetate, and a mixed solvent thereof may be used, but hexane is preferably used, but not limited thereto.

According to a preferred embodiment of the present invention, the red ginseng oil of the present invention is prepared by adding 60 ml to 1 L of a non-polar solvent to about 1 kg of red ginseng or red ginseng powder and heating at 4 to 70 ° C, preferably 24 to 65 ° C, Min to 24 hours, preferably 30 minutes to 2 hours. The obtained extract is cooled, filtered, and further concentrated under reduced pressure to remove the solvent.

The thus-prepared red ginseng oil of the present invention contains various components and contains as essential components fat, vegetable sterol, phospholipid and polyacetylene, preferably 70.0 to 90.0 parts by weight of fat, 0.1 to 15.0 parts by weight of vegetable sterol, 10.0 parts by weight of phospholipid, and 0.1 to 5.0 parts by weight of polyacetylene.

The red ginseng oil of the present invention may be contained in an amount of 0.0001 to 99.9 wt% (w / v) based on the total weight of the cosmetic composition, and preferably 0.01 to 10.0 wt% (w / v). If the amount of the red ginseng oil is less than the above range, the skin moisturizing effect can not be obtained. If the amount is above the above range, the increase in the content of the red ginseng oil does not increase the apparent effect.

The cosmetic composition according to the present invention may further contain other ingredients such as the red ginseng oil, which can give a synergistic effect to the effect of the red ginseng oil, within a range that does not impair the desired effect of the present invention have. For example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavoring agents, or carriers.

The cosmetic composition of the present invention is not particularly limited in its formulation and may be prepared into any formulation conventionally produced in the art, and examples thereof include softening agents, convergent lotion, nutritional lotion, nutritional cream, massage cream, And may be formulated into such forms as essence, pack, body lotion, body cream, body oil, body essence, gel, emulsion, body cleanser, hair dye, shampoo or rinse.

When the formulation of the cosmetic composition of the present invention is a paste, a cream or a gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide Lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component in the case of a powder or a spray. In particular, in the case of a spray, a mixture of chlorofluorohydrocarbons, Propane / butane or dimethyl ether.

When the formulation of the cosmetic composition of the present invention is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifying agent may be used as a carrier component. For example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol , Benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the cosmetic composition of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester , Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, and in the case of cleansing containing a surfactant, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, sulfosuccinic acid monoesters, A fatty acid amide ether sulfate, an alkylamidobetaine, an aliphatic alcohol, a fatty acid glyceride, a fatty acid diethanolamide, a vegetable oil, a lanolin derivative, or an ethoxylated glycerol fatty acid such as isopentanoate, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide ether sulfate, s Include Le can be used. Specifically, the softening water may contain 1.0 to 10.0% by weight of polyhydric alcohols such as propylene glycol and glycerin, and 0.05 to 2.0% by weight of surfactants such as polyethylene oleyl ether and polyoxyethylene hardened castor oil. The nutritional lotion and nutritional cream contain 5.0 to 20.0% by weight of an oil such as squalane, vaseline, octyldodecanol, and 3.0 to 15.0% by weight of a wax component such as cetanol, stearyl alcohol and beeswax in addition to red ginseng oil, And 5.0 to 30.0% by weight of polyhydric alcohols such as glycerin, propylene glycol and the like. The massage cream is prepared by adding 30.0 to 70.0% by weight of an oil such as liquid paraffin, petrolatum, isononylisononanoate in addition to red ginseng oil, and the pack is peel off containing 5.0 to 20.0% by weight of polyvinyl alcohol. A pack or a general emulsion type cosmetic can be produced with a wash off pack containing 5.0 to 30.0% by weight of pigment such as kaolin, talc, zinc oxide, titanium dioxide and the like. In addition, the cosmetic composition of the present invention may further contain additives such as a preservative component, a moisturizer, an emollient, a surfactant, an organic or inorganic pigment, an organic powder, an ultraviolet absorbent, an antiseptic, a bactericide, an antioxidant, a plant extract, A blood circulation accelerator, a cold agent, purified water and the like may be further added as a blending component. The amount is preferably 0.001 to 5.0% by weight, more preferably 0.01 to 3.0% by weight based on the total weight of the composition.

In a specific embodiment of the present invention, in order to examine the skin moisturizing effect of the red ginseng oil of the present invention prepared as described above, the red ginseng oil of the present invention and macadamia oil as a control group were respectively applied to the skin of the subject, Were measured. As a result, red ginseng oil showed a significantly higher skin moisture content than the control group, so that skin moisturizing effect was superior to macadamia oil used as a conventional moisturizing agent (see Table 2). Therefore, the red ginseng oil of the present invention has an effect of improving the moisture content of the skin and contributes to moisturizing the skin. Therefore, it can be effectively used as an effective ingredient of a cosmetic composition for moisturizing the skin.

In addition, the present invention provides a pharmaceutical composition for moisturizing skin containing red ginseng oil as an active ingredient.

In a preferred embodiment of the present invention, the red ginseng oil of the present invention is extracted from red ginseng or red ginseng and is a nonpolar solvent soluble extract of red ginseng or red ginseng powder. As the nonpolar solvent, hexane, chloroform, dichloromethane, ethyl acetate or a mixed solvent thereof may be used, and hexane is preferable.

The red ginseng oil of the present invention thus extracted contains as essential components fat, vegetable sterol, phospholipid and polyacetylene, preferably 80.0 to 90.0 parts by weight of fat, 0.1 to 15.0 parts by weight of phytosterol, 0.1 to 10.0 parts by weight of phospholipid, 0.1 to 5.0 parts by weight of polyacetylene.

The red ginseng oil of the present invention may be contained in an amount of 0.0001 to 99.9% by weight (w / v), preferably 0.01 to 10.0% by weight (w / v) based on the total weight of the pharmaceutical composition. When the red ginseng oil is less than the above range, the skin moisturizing effect can not be obtained. When the above range is exceeded, no significant increase in the effect is observed due to the increase of the content.

The administration route of the pharmaceutical composition according to the present invention includes oral, intravenous, intramuscular, intraarterial, transdermal, subcutaneous, intraperitoneal, intranasal, intestinal, topical, sublingual, or rectal administration and is preferably oral or parenteral But is not limited thereto. The parenteral route includes subcutaneous, intradermal, intravenous, intramuscular, intralesional injection or infusion techniques.

The pharmaceutical composition of the present invention may contain, in addition to the red ginseng oil of the present invention, one or more active ingredients showing the same or similar functions. The compositions may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, oral preparations, external preparations, suppositories and sterilized injection solutions according to a conventional method.

Solid form preparations for oral administration include powders, granules, tablets, capsules, soft capsules, and the like. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . As the agent for parenteral administration, the external preparation such as powders, granules, tablets, capsules, sterilized aqueous solutions, liquid preparations, non-aqueous solutions, suspensions, emulsions, syrups, suppositories and aerosols, And may be formulated into a pharmaceutical composition for external application for cream, gel, patch, spray, ointment, warning agent, lotion, liniment, pasta or cataplasm. However, the present invention is not limited thereto. Herein, the ointment for skin external use may contain 50.0 to 97.0% by weight of petrolatum and 0.1 to 5.0% by weight of polyoxyethylene oleyl-ether phosphate other than red ginseng oil. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppository bases include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like.

Such compositions may additionally contain preservatives, stabilizers, wettable or emulsifying accelerators, adjuvants such as salts and / or buffers for the control of osmotic pressure, and other therapeutically useful substances and may be prepared by conventional methods of mixing, It can be formulated according to the coating method.

The pharmaceutical composition of the present invention may be variously varied depending on various factors including the age, weight, general health, sex, administration time, route of administration, rate of excretion, drug combination and severity of a specific disease.

When the pharmaceutical composition containing the red ginseng oil of the present invention as an active ingredient is formulated in a unit dose form, it is preferable that the red ginseng oil of the present invention is contained as an effective ingredient in a unit dose of about 0.01 to 1,500 mg, The dosage required for treatment is usually, but not limited to, about 1 to 500 mg per day depending on the frequency and intensity of administration, and in some patients a higher daily dose may be desirable.

 The composition of the present invention may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers.

The red ginseng oil according to the present invention maintains a high moisture content of the skin, so that the skin moisturizing effect is excellent and can be effectively used as an effective ingredient of a pharmaceutical composition for moisturizing the skin.

The red ginseng oil according to the present invention has an excellent effect on moisturizing the skin by increasing the moisture content of the skin, and thus it can be used as a composition for moisturizing the skin.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples.

However, the following examples and experimental examples are provided only for illustrating the present invention, and the content of the present invention is not limited by the following examples and experimental examples.

< Example  1> Preparation of red ginseng oil using red ginseng powder

60 mg of hexane was added to 1 kg of red ginseng powder and refluxed at 65 ° C for 60 minutes to extract lipid soluble components. The obtained filtrate was subjected to removal of hexane under reduced pressure to obtain a dark red ginseng oil.

< Example  2> Red ginseng  Manufacture of red ginseng oil

Red ginseng oil was prepared in the same manner as in <Example 1> except that red ginseng oil was obtained using red ginseng powder instead of red ginseng powder.

< Example  3> Red ginseng oil component analysis

The red ginseng oil components obtained in Example 1 and Example 2 were analyzed by high performance liquid chromatography (HPLC).

As a result, it was confirmed that red ginseng oil contained more than 81% of the fat component, and the plant sterol, phospholipid, polyacetylene and other components (Table 1).

weight% maintain Plant sterol Phospholipids Polyacetylene Etc Example 1 81.64 10.08 5.15 0.59 2.54 Example 2 81.59 9.62 5.46 0.61 2.72

< Experimental Example  1> Skin moisturizing effect of red ginseng oil

In order to measure the skin moisturizing effect of the red ginseng oil prepared in Example 2, the moisture content of the skin was measured. The skin moisture content is the ability of the skin to contain water in a normal skin condition. The skin of the subject is washed with 70% ethanol, and red ginseng oil or macadamia oil 0.1 g / To the stock measurement site precisely. Moisture content of the subjects was evaluated by a moisture meter (Corneometer CM 825, C + K, Germany) at intervals of 30 minutes for a total of 5 hours. In order to measure the skin moisturizing effect of red ginseng oil, macadamia oil commonly used in moisturizing cosmetics was used as a control.

As a result, it was confirmed that red ginseng oil has more effective skin moisturizing effect than that of macadamia oil, which is known to be excellent in moisture resistance, by about 20% (Table 2).

time Moisture retention (%) Macadamia oil Example 2 0 minutes 40 42 30 minutes 194 232 60 minutes 180 220 90 minutes 176 218 120 minutes 155 198 150 minutes 157 181 180 minutes 158 189 210 minutes 156 173 240 minutes 128 175 270 minutes 140 164 300 minutes 134 162

< Manufacturing example  1> Cosmetics  Preparation of composition

<1-1> Production of softening longevity

The softened lotion containing the red ginseng oil of the present invention as an active ingredient was prepared as shown in Table 3 below.

Raw material Content (parts by weight) <Example 1> Red ginseng oil 10.00 1,3-butylene glycol 1.00 Disodium iodide 0.05 Allantoin 0.10 Dipotassium glycyrrhizate 0.05 Citric acid 0.01 Sodium citrate 0.02 Glycereth-26 1.00 Arbutin 2.00 Hydrogenated castor oil 1.00 ethanol 30.00 Preservative a very small amount coloring agent a very small amount Flavoring agent a very small amount Purified water Balance

<1-2> Preparation of nutritional cream

The nutritional cream containing the red ginseng oil of the present invention as an active ingredient was prepared in accordance with the composition shown in Table 4 below.

Raw material Content (parts by weight) <Example 1> Red ginseng oil 10.0 1,3-butylene glycol 7.0 glycerin 1.0 D-Panthenol 0.1 Plant extract 3.2 Magnesium aluminum silicate 0.3 PEG-40 stearate 1.2 Stearic acid 2.0 Polysorbate 60 1.5 Chin type glyceryl stearate 2.0 Sorbitan sesquioleate 1.5 Cetearyl alcohol 3.0 Mineral oil 4.0 Squalane 3.8 Carlyric / capric triglyceride 2.8 vegetable oil 1.8 Dimethicone 0.4 Dipotassium glycyrrhizate a very small amount Allantoin a very small amount Sodium hyaruronate a very small amount Tocopheryl acetate Suitable amount Triethanolamine Suitable amount Preservative Suitable amount Flavoring agent Suitable amount Purified water Balance

<1-3> Production of Lotion

Lotions containing the red ginseng oil of the present invention as an active ingredient were prepared according to the composition shown in Table 5 below.

Raw material Content (parts by weight) Cetostearyl alcohol 1.6 Stearic acid 1.4 Pro-type glycerin monostearate 1.8 FAGE -100 stearate 2.6 Sorbic acid sesquioleate 0.6 Squalene 4.8 Macadia oil 2 Jojoba oil 2 Tocopheryl acetate 0.4 Methylpolysiloxane 0.2 Ethylparaben 0.1 Tocopheryl acetate 0.4 Methylpolysiloxane 0.2 Ethylparaben 0.1 Propylparaben 0.1 1,3-butylene glycol 4 Methylparaben 0.1 Xanthan gum 0.1 glycerin 4 d-Pandenol 0.15 Allantoin 0.1 <Example 2> Red ginseng oil 3.5 Carbomer (2% aq. Sol) 4 Triethanolamine 0.15 ethanol 3 pt 41891 0.1 p-H20 48.3

< Manufacturing example  2> Of the pharmaceutical composition  Produce

<2-1> Preparation of ointment for external skin

Skin ointment containing the red ginseng oil of the present invention as an active ingredient was prepared according to the composition of the following [Table 6].

Raw material Content (parts by weight) Purified water 100 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 15.0 Beta Glucan 7.0 Carbomer 0.1 <Example 1> Red ginseng oil 20 Caprylic capric triglyceride 3.0 Squalane 1.0 Cetearyl glucoside 1.5 Sorbitan stearate 0.4 Cetearyl alcohol 1.0 antiseptic Suitable amount incense Suitable amount Pigment Suitable amount Wax 4.0

<2-2> External application Patchy  Produce

Skin patches containing the red ginseng oil of the present invention as an active ingredient were prepared according to the composition shown in Table 7 below.

Raw material Content (parts by weight) <Example 2> Red ginseng oil 10.0 Hexylene glycol 20.0 Diethylamine 0.7 Polyacrylic acid 1.0 Sodium sulphate 0.1 Polyoxyethylene lauryl ether (E.0 = 9) 1.0 Polyhydroxyethylene cetyl stearyl ether 1.0 Viscous paraffin oil 2.5 Caprylic acid ester / capric acid ester (cetiol LC) 2.5 Polyethylene glycol 400 3.0 Deionized water 70

<2-3> Sanje  Produce

2 g of red ginseng oil of Example 2

Lactose 1 g

The above components were mixed and packed in airtight bags to prepare powders.

<2-4> Preparation of tablets

100 mg of red ginseng oil of Example 2

Corn starch 100 mg

100 mg of milk

2 mg of magnesium stearate

After mixing the above components, tablets were prepared by tableting according to a conventional method for producing tablets.

&Lt; 2-5 > Preparation of capsules

100 mg of red ginseng oil of Example 1

Corn starch 100 mg

100 mg of milk

2 mg of magnesium stearate

After mixing the above components, the capsules were filled in gelatin capsules according to the conventional preparation method of capsules.

&Lt; 2-6 >

1 g of red ginseng oil of Example 1

Lactose 1.5 g

Glycerin 1 g

0.5 g of xylitol

After mixing the above components, they were prepared so as to be 4 g per one ring according to a conventional method.

<2-7> Preparation of granules

150 mg of red ginseng oil of Example 2

Soybean extract 50 mg

200 mg of glucose

600 mg of starch

After mixing the above components, 100 mg of 30% ethanol was added and the mixture was dried at 60 캜 to form granules, which were then filled in a capsule.

Claims (11)

A cosmetic composition for skin moisturizing, comprising red ginseng oil extracted as a nonpolar solvent as an active ingredient.
The method according to claim 1,
Wherein the red ginseng oil is extracted from red ginseng or red ginseng.
delete The method according to claim 1,
Wherein the nonpolar solvent is any one selected from the group consisting of hexane, chloroform, dichloromethane, ethyl acetate, and a mixed solvent thereof.
The method according to claim 1,
Wherein the red ginseng oil comprises fat, vegetable sterols, phospholipids and polyacetylenes.
The method according to claim 1,
The cosmetic composition may be any one selected from the group consisting of softening agents, astringent lotion, nutritional lotion, nutritional cream, massage cream, essence, pack, body lotion, body cream, body oil, body essence, gel, emulsion and body cleanser &Lt; / RTI &gt;
A pharmaceutical composition for moisturizing skin containing red ginseng oil extracted as a nonpolar solvent as an effective ingredient.
The method of claim 7,
Wherein the red ginseng oil is extracted from red ginseng or red ginseng.
delete The method of claim 7,
Wherein the nonpolar solvent is any one selected from the group consisting of hexane, chloroform, dichloromethane, ethyl acetate, and a mixed solvent thereof.
The method of claim 7,
Wherein the red ginseng oil comprises fat, plant sterols, phospholipids and polyacetylenes.