KR101994300B1 - Ointment composition containing black garlic - Google Patents

Abstract

The present invention relates to a peel-off type ointment composition containing a black garlic ingredient, and more particularly to a peel-off type ointment composition comprising a purified water, a solvent, a black garlic powder, a green onion powder, an onion powder, menthol, a surfactant, a thickener and an emulsifier.
The peel-off type ointment composition containing the black garlic component comprising the above components contains an alicin-rich black garlic powder, green onion powder and onion powder, exhibiting excellent sterilization, antibacterial and detoxifying effects, and forming a thin film after skin application.

Description

{OINTMENT COMPOSITION CONTAINING BLACK GARLIC}

More particularly, the present invention relates to a peel-off type ointment composition containing a black garlic ingredient, and more particularly, to an ointment composition containing black germ powder, alopecia powder and onion powder rich in allysine, exhibiting excellent sterilization, antibacterial and detoxifying effects, And a black gum component to be formed.

In our body, the skin is in direct contact with the external environment and functions to protect our body from the outside. It is the primary shield of the human body to maintain the internal consistency through body temperature control and to protect the main internal organs from the outside.

In addition, as the other organs of the human body, the performance gradually deteriorates as the skin ages, and the production of hyaluronic acid and collagen which maintains moisturization of the skin is reduced, and the elasticity of the skin is maintained As elastin becomes weaker, skin aging appears.

In addition to the skin aging, there are various skin diseases such as atrophy, acne, eczema, and psoriasis, and damage due to external stimuli due to scars, burns, and the like, as well as skin aging, keratinization, wrinkles, dullness and dryness .

Itching, on the other hand, is an unpleasant sensation that causes the urge to scratch or rub the skin. In general, itching can be caused by internal and external stimuli, which can be caused by ingestion of food or by chemical allergens due to biological allergens and chemicals such as microorganisms, house dust mites and ticks have. These allergen-induced itching can be accompanied by inflammation in severe cases. In the case of atopic dermatitis, severe itching and inflammation are associated with intractable skin disease that can impair quality of life.

Accordingly, various efforts and studies on a composition capable of alleviating itching and skin irritation caused by insect worms, constitution, and the like have been actively carried out all over the world. In particular, a physiologically active substance obtained from a plant is introduced Which is capable of restoring the inherent defense function of the skin itself, has been actively developed.

Korean Patent Registration No. 10-1579728 entitled " Natural Skin Dermatological Composition Containing Medicinal Plant Extracts as Active Ingredients " and Korean Patent Registration No. 10-0772575 " Dermatological Ingredient Composition Containing Extract of Medicinal Extracts " Although the contents of improving the skin diseases, itching and inflammation due to the plant extract are described, since the main ingredients are mostly composed of chemical components, they may be ineffective or cause side effects when they are used for a long period of time. There is a problem that the therapeutic effect is deteriorated.

It is an object of the present invention to provide a peel-off type ointment composition containing a black garlic ingredient which contains allysine-rich black garlic powder, green onion powder and onion powder, exhibits excellent sterilization, antibacterial and detoxifying effects and forms a thin film after skin application.

In one embodiment, the content of the disclosure is based on a peel-off type ointment composition containing a black garlic component, characterized by comprising purified water, a solvent, a black garlic powder, a large wave powder, an onion powder, menthol, a surfactant, a thickener and an emulsifier .

Preferably, the peel-off type ointment composition containing the black garlic ingredient contains 100 parts by weight of purified water, 45 to 55 parts by weight of solvent, 0.9 to 1.1 parts by weight of black garlic powder, 0.65 to 0.85 part by weight of onion powder, 0.65 to 0.85 part by weight of onion powder 0.9 to 1.1 parts by weight of menthol, 2 to 3 parts by weight of a surfactant, 35 to 40 parts by weight of a thickener and 8 to 12 parts by weight of an emulsifier.

More preferably, the thickener may consist of a carbomer.

More preferably, the surfactant may be composed of tetraethylene amine.

Even more preferably, the emulsifier may be composed of polyvinyl alcohol.

Even more preferably, the solvent may be composed of ethanol or glycerin.

As described above, the peel-off type ointment composition containing the black garlic ingredient exhibits excellent sterilizing, antibacterial and detoxifying effects by containing alicin-rich black garlic powder, green onion powder and onion powder, and shows excellent effect of forming a thin film after skin application .

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph showing an ointment composition prepared from a peel-off type ointment composition containing the disclosed black garlic ingredient.

Hereinafter, preferred embodiments of the present invention and physical properties of the respective components will be described in detail with reference to the accompanying drawings. However, the present invention is not limited thereto, And this does not mean that the technical idea and scope of the present invention are limited.

The peel-off type ointment composition containing the disclosed black garlic ingredient is composed of purified water, a solvent, a black garlic powder, a green onion powder, an onion powder, menthol, a surfactant, a thickener and an emulsifier, and comprises 100 parts by weight of purified water, 45 to 55 parts by weight of solvent, 0.9 to 1.1 parts by weight of powder, 0.65 to 0.85 part by weight of onion powder, 0.65 to 0.85 parts by weight of onion powder, 0.9 to 1.1 parts by weight of menthol, 2 to 3 parts by weight of surfactant, 35 to 40 parts by weight of thickener and 8 to 12 parts by weight of emulsifier Is preferable.

The solvent is comprised of 45 to 55 parts by weight of ethanol or glycerin. The emulsifier is diluted so that when the emulsifier diluent is reacted with the thickener and the surfactant, the ointment composition is formed into a thin film after skin application So that it can be provided as a peel-off type.

If the content of the solvent is less than 45 parts by weight, the viscosity of the ointment composition may be excessively increased to cause pain when the film is removed from the skin. When the content of the solvent exceeds 55 parts by weight, the viscosity of the ointment composition becomes too low, Becomes difficult.

The black garlic powder is contained in an amount of 0.9 to 1.1 parts by weight, the black powder is contained in an amount of 0.65 to 0.85 part by weight, and the onion powder is contained in an amount of 0.65 to 0.85 part by weight. Has a large amount of an alicin component excellent in antimicrobial and detoxifying effects, and thus plays a role of imparting sterilizing, antibacterial and detoxifying effects to the disclosed peel-off type ointment composition.

The black garlic powder is dehydrated after cutting, peeling and washing of the bulb portion of the black garlic, crushing the garlic eggs, and then adding the dehydrated black garlic pulverized material to the extractor and pressing the extract, the extract containing the large amount of allysine is extracted, Dried and finely pulverized, and the powdered green onion and the powdered onion are also prepared through the same process.

When the content of the black garlic powder is less than 0.9 part by weight, the effect of sterilization, antibacterial and detoxification of the disclosed peel-off type ointment composition is deteriorated. When the content of the black garlic powder exceeds 1.1 parts by weight, And the garlic flavor becomes strong, so that the merchantability may be lowered.

At this time, the mixing amount of the black garlic powder, the green onion powder and the onion powder is preferably 1: 0.75: 0.75 part by weight, and the content of allysine is the highest when the mixing ratio is as described above.

The menthol contains 0.9-1.1 parts by weight of the menthol. The softening agent imparts a cooling sensation to the peel-off type ointment composition containing the disclosed black garlic ingredient and has a role of suppressing a strong incense of the black garlic powder, the green onion powder and the onion powder due to the unique flavor.

At this time, if the content of menthol is less than 0.9 part by weight, the above effect is insignificant. If the content of menthol exceeds 1.1 parts by weight, the effect is not greatly improved but the manufacturing cost is increased.

The surface active agent contains 2 to 3 parts by weight of polyvinyl alcohol. The surfactant can be mixed with the purified water and the solvent uniformly to exhibit homogeneous physical properties.

If the content of the surfactant is less than 2 parts by weight, the above-mentioned effect is insignificant. If the content of the surfactant is more than 3 parts by weight, the above effect may not be significantly improved but skin irritation may be caused.

The thickening agent is contained in an amount of 35 to 40 parts by weight and is composed of a carbomer. The thickening agent imparts appropriate viscosity to the peel-off type ointment composition containing the disclosed black garlic ingredient. After the ointment composition is applied to the skin, So that a thin film can be formed.

When the content of the thickener is less than 35 parts by weight, the viscosity of the ointment composition is too low to form a film. When the content of the thickening agent is more than 40 parts by weight, the viscosity of the ointment composition is excessively demonstrated, Lt; / RTI >

The emulsifier contains 8 to 12 parts by weight of polyvinyl alcohol, and serves to uniformly mix the carbomer with the purified water.

If the content of the emulsifier is less than 8 parts by weight, the effect is insignificant. If the content of the emulsifier is more than 12 parts by weight, the effect is not greatly improved but the manufacturing cost is increased and the skin irritation of the ointment composition is increased .

The fillet-type ointment composition comprising the above-described components is prepared by stirring the mixture of the parenteral agent three times over the excipient. The excipient is prepared by mixing 8 to 12 parts by weight of an emulsifier with 100 parts by weight of purified water, The mixture was stirred for 7 to 9 hours using a stirrer. When the injected emulsifier was evenly mixed, 35 to 40 parts by weight of a thickener were added in three portions and stirred. After the stirring, Stirring is performed after adding 2 to 3 parts by weight of the active agent, and 0.9 to 1.1 parts by weight of menthol pulverized by a rod bowl or the like is added and stirred.

Also, the casting agent is prepared by mixing 0.9 to 1.1 parts by weight of black garlic powder, 0.65 to 0.85 part by weight of black garlic powder and 0.65 to 0.85 part by weight of onion powder into 45 to 55 parts by weight of solvent, ≪ / RTI > for 15 minutes.

Hereinafter, the method for producing the peel-off type ointment composition containing the disclosed black gingival component and the physical properties of the ointment composition prepared through the production method will be described with reference to examples.

PREPARATION EXAMPLE 1 Preparation of Alicin-Containing Component

Table 1 below shows the content of allysine after mixing the black garlic powder, green onion powder and onion powder in the ratio shown in Table 1 below.

(However, the content of allysine was confirmed by DPPH antioxidant assay.)

<Table 1>

As shown in Table 1, when the content of black garlic powder, green onion powder, and onion powder was 0.4 g of black garlic powder, 0.3 g of green onion powder, and 0.3 g of onion powder, the content of allysine was the best.

&Lt; Preparation Example 2 > Preparation of casting agent

To 40 parts by weight of solvent (ethanol), 1 part by weight of black garlic powder, 0.75 part by weight of green onion powder and 0.75 part by weight of onion powder were mixed and stirred for 15 minutes at a temperature of 50 DEG C and 600 rpm using a stirrer to prepare a mold Respectively.

&Lt; Preparation Example 3 > Preparation of excipient

10 parts by weight of an emulsifier (polyvinyl alcohol) was added to 100 parts by weight of purified water through a stirrer (800 rpm, RT) in an amount of 2 parts by weight and stirred for 8 hours using a stirrer. When the injected emulsifier was evenly mixed, 37.5 parts by weight of Carbopol 940) were added in three portions and stirred. After stirring, 2.5 parts by weight of a surfactant (tetraethyleneamine) was added and stirred. 1.0 part by weight of crushed menthol was added and stirred to prepare an excipient.

&Lt; Preparation Example 4 > Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the content of the thickening agent was changed to 12.5 parts by weight to prepare an excipient.

Preparation Example 5 Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the content of the thickener was changed to 25 parts by weight to prepare an excipient.

&Lt; Preparation Example 6 > Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the content of the thickener was changed to 50 parts by weight to prepare an excipient.

&Lt; Preparation Example 7 > Preparation of excipient

The procedure of Preparation Example 3 was repeated, except that the content of the thickening agent was changed to 62.5 parts by weight to prepare an excipient.

&Lt; Preparation Example 8 > Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the emulsifier content was changed to 2.5 parts by weight to prepare an excipient.

Preparation Example 9 Preparation of Excipient

The procedure of Preparation Example 3 was followed except that the emulsifier content was changed to 5 parts by weight to prepare an excipient.

Preparation Example 10 Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the emulsifier content was changed to 7.5 parts by weight to prepare an excipient.

&Lt; Preparation Example 11 > Preparation of excipient

The procedure of Preparation Example 3 was repeated except that the emulsifier content was changed to 12.5 parts by weight to prepare an excipient.

PREPARATION EXAMPLE 12 Preparation of Excipient

Proceeding in the same manner as in Preparation Example 3, except that the emulsifier content was changed to 15 parts by weight, an excipient was prepared.

Preparation Example 13 Preparation of excipient

Proceeding in the same manner as in Preparation Example 3, 2.5 parts by weight of menthol was added to prepare an excipient.

&Lt; Preparation Example 14 > Preparation of excipient

Proceeding in the same manner as in Preparation Example 3, except that the content of menthol was changed to 2 parts by weight, an excipient was prepared.

&Lt; Preparation Example 15 > Preparation of excipient

Proceeding in the same manner as in Preparation Example 3, except that the content of menthol was changed to 1.5 parts by weight, an excipient was prepared.

Production Example 16 Production of Excipient

Proceeding in the same manner as in Preparation Example 3, except that the content of menthol was 0.5 part by weight, an excipient was prepared.

&Lt; Example 1 >

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 3 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 1 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 4 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 2 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 5 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 3 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Production Example 6 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 4 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 7 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 5 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Production Example 8 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 6 >

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 9 three times and then stirred to prepare a peel-off type ointment composition containing black garlic ingredients.

&Lt; Comparative Example 7 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 10 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 8 >

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 11 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 9 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 12 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 10 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 13 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 11 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 14 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 12 >

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Preparation Example 15 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

&Lt; Comparative Example 13 &

The casting agent prepared in Preparation Example 2 was mixed with the excipient prepared in Production Example 16 three times and then stirred to prepare a peel-off type ointment composition containing a black garlic ingredient.

The properties of the peel-off type ointment compositions containing the black garlic ingredients prepared in Example 1 and Comparative Examples 1 to 13 were measured and are shown in Table 2 below.

(However, the physical properties of the ointment composition were measured by a 5-point scale method for skin irritation, removal performance, and film formation in 20 subjects. The skin irritancy was expressed as a mean value after adding each item. 3, slightly irritation, 2 points, very irritation, 1 point, skin trouble induction, 5 points of removal, 4 points of pain, 3 points of pain, 2 4 points; good film formation; 3 points; moderate, 2 points; cracks in the film, cracks in the film, 1 point; no film formation).

<Table 2>

As shown in Table 2 above, the ointment composition prepared through Example 1 of the present invention has the best satisfaction with the removal performance and the film formation as compared with the ointment compositions prepared through Comparative Examples 1 to 13.

Claims (6)

Characterized in that the composition is composed of purified water, a solvent, a black garlic powder, a large wave powder, an onion powder, menthol, a surfactant, a thickener and an emulsifier.
The method according to claim 1,
The peel-off type ointment composition containing the black garlic component is prepared by mixing 100 parts by weight of purified water, 45 to 55 parts by weight of solvent, 0.9 to 1.1 parts by weight of black garlic powder, 0.65 to 0.85 part by weight of onion powder, 0.65 to 0.85 part by weight of onion powder, To 1.1 parts by weight of a surfactant, 2 to 3 parts by weight of a surfactant, 35 to 40 parts by weight of a thickener, and 8 to 12 parts by weight of an emulsifier.
The method according to claim 1 or 2,
Wherein the thickener is composed of a carbomer.
The method according to claim 1 or 2,
Characterized in that the surfactant is tetraethylene amine. The composition of claim 1, wherein the surfactant is tetraethylene amine.
The method according to claim 1 or 2,
Characterized in that the emulsifier is composed of polyvinyl alcohol.
The method according to claim 1 or 2,
Wherein the solvent is ethanol or glycerin. The composition of claim 1, wherein the solvent is ethanol or glycerin.

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