KR20160116733A - Soap Containing Calendula Infused Oil, and Method for Manufacturing the Same - Google Patents
Soap Containing Calendula Infused Oil, and Method for Manufacturing the Same Download PDFInfo
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- KR20160116733A KR20160116733A KR1020150044916A KR20150044916A KR20160116733A KR 20160116733 A KR20160116733 A KR 20160116733A KR 1020150044916 A KR1020150044916 A KR 1020150044916A KR 20150044916 A KR20150044916 A KR 20150044916A KR 20160116733 A KR20160116733 A KR 20160116733A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D13/00—Making of soap or soap solutions in general; Apparatus therefor
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
Abstract
Description
The present invention relates to a method for manufacturing a calendula fused oil-containing soap which encapsulates a calendula component having an effect useful for human skin and prevents it from deteriorating the efficacy of calendula by external factors such as heat, light and oxygen by adding it to soap and ≪ / RTI >
Soap is one of life necessities which is used to remove foreign matter such as washing water or body, deodorant, deodorant, skin protection and so on, and it is classified into various kinds according to the state of soap, usage, main ingredient and so on.
Soap refers to a generic term for a wide range of metal salts such as saturated and unsaturated higher fatty acids, fatty acids, resin acids, and naphthenic acid, and refers to a water-soluble alkali metal salt of a higher fatty acid, which is mainly used for cleaning, as a concept of negotiation.
As a conventional method for producing soap, various animal oils or vegetable oils are saponified with sodium hydroxide to prepare a soap base, and then, if necessary, a flavor for removing unpleasant odor or moisturizing property of the skin, And further adding various additives such as a softener and a moisturizer.
The wet process can be divided into a wet process for producing a soap base material and a dry process for mixing various functional additives to the produced soap base material followed by a forming and drying process. In the wet process, the oil is mixed with sodium hydroxide Saponification to produce soap, neutralization to prepare soap by mixing sodium hydroxide with fatty acid, and methylation to produce soap by preparing methyl ester by treatment with methanol and sodium hydroxide, And methyl ester saponification.
Soap, which is produced in this way, has been mainly used to clean dirt and foreign matter adhering to the skin of the face or body. However, in recent years, when the living standard is improved and the skin beauty is highlighted, Functional soaps containing several active ingredients have been developed and are being released.
That is, in addition to the conventional criteria for selection of soap, such as washing power, skin harmlessness, amount of bubbles, period of use due to abrasion, and the like, Soaps with various functionalities are preferred, and there is a tendency to prefer environmentally-friendly natural soaps using natural vegetable materials rather than synthetic soaps made of chemical compounds
For example, various natural pigments and fragrances are added to eliminate the characteristic odor of keeping and increase the value of the product. The fragrance which is mainly used is preferred to the fragrance of natural plant system, Products with the addition of extracts of plants (for example, ginseng, cucumber, apricot, aloe, lemon, citron and mugwort) or combinations of these plants with specific odors have been introduced.
In recent years, various functionalities such as soaps containing herbal ingredients for preventing and treating skin diseases such as acne, dandruff, foot odor and atopy, soaps having the effect of promoting blood circulation and elimination of waste products, Soap has been proposed.
As such a functional soap, Korean Patent Registration No. 1424354 discloses an extract of a first herb medicine group having strong antimicrobial and bactericidal action (anthurium, bogolgia, rhododendron, marigold), a skin-friendly affinity, a rich source of skin nutrition The second plant herb medicine group (licorice, fig, aloe, spruce tree, ginseng saplings, pine tree, Songguji, bee casualty) which is effective for prevention and healing of various skin diseases is enriched with fermentation liquid and gives radiance and elasticity to skin. At the same time, a composition composed of a natural antioxidant capable of reducing the production of keratin and sebum and preventing aging (consisting of a dandruff, a formulator, a tincture, a walnut seed, a walnut, a passer, a yulmu, a grape seed), a preservative, A method for producing a functional soap using a plant herb medicine prepared by adding the herbicide to a substrate is disclosed.
The soap is added to the soap with the skin cosmetic and therapeutic effects of the first and second herb medicine groups and the natural antioxidant to prevent and cure skin diseases or inflammatory diseases and reduce the aging and wrinkles of the skin So that functional soap can be produced.
Korean Patent Laid-Open Publication No. 2014-0123426 discloses a soap and cosmetic composition containing gold beads coated with gold on the surface of a polymer bead. The composition comprises a weak alkaline fatty acid, calendula intussusdid oil, vegetable glycerin, etc. Base oil, jojoba oil, evening primrose oil, sweet almond oil, calendula fused oil, vitamin E, hyaluronic acid, lilac flavor, paprika powder, aroma essential oil, lavender and eucalyptus oil.
The above-mentioned soap can provide anti-inflammation, wrinkle improvement, skin regeneration effect and gold bead massage and scrubbing effect of gold, and the oil component and the plant ingredient have the advantages of moisturizing, orienting, preserving and preventing diseases.
As described above, most of the conventional soaps are prepared by adding various functional natural materials to the soap base. In order to take advantage of natural materials, artificial preservatives are not usually added so that the natural materials can be light, heat, air There is a problem that the volatile components are volatilized and removed during storage, and the functionality of the soap is deteriorated due to the presence of many volatile substances.
Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above problems, and it is an object of the present invention to provide a calendula ingredient, which is a natural plant material added to soap to impart functionality thereto,
In order to solve the above-mentioned problems, the present invention provides a method for producing a water-soluble polymer, which comprises mixing and stirring 100 parts by weight of an oil with 35 to 55 parts by weight of an aqueous solution of sodium hydroxide having a sodium hydroxide content of 30 to 40% 0.5 to 3.0 parts by weight of a calendula fused oil capsule containing calendula fused oil contained in a wall material composed of lecithin and an amphiphilic block copolymer and saponifying the mixture when 100 to 150 seconds elapse after the mixing; Pouring the mixture of the saponified oil, aqueous sodium hydroxide solution and calendula fused oil capsules into a mold, allowing the mixture to stand at 40 to 55 ° C for 20 to 30 hours to solidify; And drying the solidified mixture at a temperature of 20 to 50 DEG C and a relative humidity of 25 to 35% for 40 to 50 days.
The oil is preferably at least one selected from the group consisting of olive oil, castor oil, camellia oil, evening oil, palm oil, coconut oil, palm oil, palm kernel oil, sunflower oil, grape seed oil, soybean oil, rice bran oil and cottonseed oil , And the mixing temperature of the oil and the aqueous solution of sodium hydroxide is preferably 40 to 50 ° C.
In addition, the calendula fused oil capsules are prepared by mixing and homogenizing 5 to 10 parts by weight of calendula fused oil and 10 to 20 parts by weight of lecithin in 100 parts by weight of water; Drying the homogenized water, calendula fused oil and lecithin to coat lecithin on the surface of the calendula fused oil particles; Mixing and homogenizing 5 to 10 parts by weight of calendula fused oil coated with lecithin and 10 to 20 parts by weight of an amphiphilic block copolymer in 100 parts by weight of an organic solvent; And drying the homogenized organic solvent, lecithin-coated calendula fused oil and amphiphilic block copolymer to sequentially coat lecithin and an amphipathic block copolymer on the surface of calendula fused oil The amphiphilic block copolymer is preferably selected from the group consisting of polyethylene glycol-polycaprolactone, methoxypolyethylene glycol-polycaprolactone, poloxamer, or poloxarane, or the organic solvent is selected from the group consisting of methanol, ethanol, acetone, tetrahydrofuran, dimethylformamide Or dimethyl sulfoxide.
The present invention also provides soaps containing calendula fused oil, comprising capsules prepared by the above process and containing calendula fused oil in a wall material comprised of lecithin and an amphipathic block copolymer.
The soaps containing the calendula fused oil of the present invention are characterized in that a calendula component useful for the disease skin is added to the soap and a coating film of lecithin and an amphiphilic block copolymer is formed on the surface of the fused oil particles of calendula, , It is possible to maintain the effectiveness of calendula even after long-term storage of the soap containing calendula fused oil.
In addition, lecithin coating with calendula fused oil has health promotion and anti-aging efficacy, which, together with calendula fused oil, imparts a beneficial effect on skin health, and the lipophilic block of the amphiphilic block copolymer is externally oriented And the fused oil of calendula is uniformly dispersed in the soap and the lipophilic block of the amphiphilic block copolymer is combined with the oil so that the calendula component is washed out in water when using the manufactured soap With soap bubbles, it can act completely on human skin.
Natural soaps can be classified into MP (Melt & Pour) soap, HP (Hot Process) soap and CP (Cold Process) soap according to the manufacturing method.
MP Soap is a method of dissolving soap base material and pouring it into a mold together with additives. It has good cleaning power and can be used immediately, but it is required to add glycerin, collagen, honey etc. because of low moisture content. HP Soap is mixed with sodium hydroxide and oil at high temperature It is also called as transparent soap and glycerin soap. It is produced by aging at room temperature for 2 ~ 3 hours after heat treatment and 40 ~ 50 minutes by non-water bath method. It has excellent detergency and long lasting fragrance. It is saponified by reacting oil and sodium hydroxide at a low temperature and then adding various additives to it. It is made by aging at room temperature for about 6 weeks and the soap is opaque.
Among the above-mentioned natural soap manufacturing methods, the CP soap manufacturing method is used. Since the CP soap manufacturing method is saponified at a low temperature, there is no deterioration due to high temperature heat such as MP soap or HP soap, There is an advantage that the efficacy can be widely obtained.
First, an oil to be used for the soap base material is prepared.
The oil can be used both as a vegetable oil or as an animal oil. Animal oil such as tallow has a low-price advantage and can be used in a variety of fields such as olive oil, castor oil, camellia oil, evening oil, palm oil, coconut oil, palm oil, Vegetable oils such as oil, grape seed oil, soybean oil, rice bran oil, and cottonseed oil have an advantage in that the active ingredient of the plant can be contained in the soap, and it is preferable to use a vegetable oil in order to produce a more functional natural soap.
Next, an aqueous solution of sodium hydroxide having a sodium hydroxide content of 30 to 40% by weight is prepared by mixing sodium hydroxide and water, and sodium hydroxide reacts with water to generate a high temperature, so that it is cooled and adjusted to a temperature of 40 to 50 ° C.
Next, the oil is heated to 40 to 50 DEG C, and then 35 to 55 parts by weight of an aqueous sodium hydroxide solution adjusted to the above temperature is added to 100 parts by weight of the oil, followed by stirring to progress saponification reaction.
If the content of the aqueous sodium hydroxide solution is less than 35 parts by weight, the saponification reaction is insufficient. If the amount exceeds 55 parts by weight, the soap becomes irritating and deteriorates in detergency. The temperature of the oil and aqueous sodium hydroxide solution It is adjusted to the above temperature for easy and uniform mixing and ease of soap making.
The oil and the sodium hydroxide aqueous solution are gradually thickened by the saponification reaction, and when they are dripped down, they become a trace state where marks are left on the surface. During the saponification reaction, oil and an aqueous solution of sodium hydroxide And 100 to 150 seconds after mixing, the calendula infused oil is added to the reaction product in the reaction.
Calendula is an annual plant belonging to Asteraceae. It is also known as marigold. It is effective for dry skin, sensitive skin and atopic skin because of anti-inflammation, antifungal, antioxidant, skin softening effect and skin irritation reducing effect. It is effective for eczema, dermatitis, It is also effective for sterilization, sedation for the central nervous system, hypertension healing, and lowering the reflex excitement.
Calendula fused oil is a method in which calendula oil is immersed in vegetable oil so that the calendula oil component is eluted into oil. The calendula flaxseed oil can be used in all of the outposts of calendula plants, but the flower parts are excellent in efficacy and are well- And the utility of the vegetable oil as well as the fraction of the oiliness of calendula are combined to double their utility.
In addition, calendula fused oil can be purchased directly from the market, or it can be prepared directly by immersing calendula in vegetable oil. In the case of direct manufacture, calendula is dried and mixed with vitamin E and olive oil, grape seed oil , Jojoba oil, green tea seed oil, almond oil, etc., it is stored for more than 2 weeks and occasionally shaken. When calendula ingredient is oiled, it is filtered, and solid matter is removed to obtain calendula fused oil have.
Soap which is main ingredient of oil keeps coloring and odor by the rancidity of the oil after a long time. Calendula fused oil has excellent antibacterial and antioxidant ability and prevents or reduces such rancidity. Thereby increasing storage stability.
The natural soap prepared by the above-mentioned method has no harmfulness and shows excellent moisturizing effect because it does not contain synthetic fragrance and artificial coloring matter. The preservability of soap is increased due to antibacterial and antioxidant ability of calendula fused oil, As the preservative is not added, the shelf life is short compared with synthetic soap containing preservatives and the volatile flavor of calendula fused oil, which is volatile during storage, is volatilized and its function and merchantability are lowered There are disadvantages.
In the present invention, in order to overcome the disadvantages of such natural soap, the calendula fused oil is encapsulated in a wall material made of lecithin and an amphipathic block copolymer to increase storage stability.
The lecithin and the amphiphilic block copolymer have both of the two conflicting properties of the hydrophilic block and the hydrophobic block in one molecule, and form an emulsion in the water or oil phase to disperse and stabilize the calendula fused oil. .
First, when lecithin is homogenized in water together with calendula fused oil, lecithin forms micelles in a state of being dispersed in water together with calendula fused oil, and when water is removed by drying in this state, the lipophilic block of lecithin The carendula is oriented in the fused oil particle direction, that is, the center portion, and the hydrophilic block forms the wall material in a form in which lecithin is coated on the surface of the calendula fused oil particle in the outwardly oriented state.
The lecithin is a phospholipid composed of a fatty acid group having a strong lipophilic property on one side and a phospholipid and choline having a strong hydrophilic property on the other side. The lecithin is abundant in egg yolk, soybean, pine nut, walnut, liver and brain.
Among these lecithin-containing foods, soybean-derived lecithin is the most preferable. Lecithin obtained from soybean contains a lot of linoleic acid of soybean, so that skin conditioning effect of linoleic acid and suppression of eczema, psoriasis and melanin production are added to soap Especially, vitamin E contained in beans has an antioxidant function, which has an effect of increasing the storage stability of soap.
Next, calendula fused oil coated with lecithin on the surface is dissolved in an organic solvent together with an amphiphilic block copolymer and homogenized, whereby an amphiphilic block copolymer is dispersed in an organic solvent together with calendula fused oil coated with lecithin The hydrophilic block of the amphipathic block copolymer is orientated to the direction of the fused oil of calendula, that is, the center, and the lipophilic block is oriented in the outward direction Forms a wall material in which lecithin and an amphiphilic block copolymer are sequentially coated on the surface of calendula fused oil particles.
Preferably, the amphiphilic block copolymer is polyethylene glycol-polycaprolactone, methoxy polyethylene glycol-polycaprolactone, poloxamer, or poloxalene. The amphiphilic block copolymer is preferably a polyethylene glycol-polycaprolactone, a methoxypolyethylene glycol-polycaprolactone, And the organic solvent is preferably methanol, ethanol, acetone, tetrahydrofuran, dimethylformamide, or dimethyl sulfoxide.
Preferably, the mixing ratio of the materials to be mixed is 5 to 10 parts by weight of calendula fused oil and 10 to 20 parts by weight of lecithin based on 100 parts by weight of water, and calendula fused oil coated with lecithin on the basis of 100 parts by weight of organic solvent 5 to 10 parts by weight and 10 to 20 parts by weight of the amphiphilic block copolymer.
The above mixing ratio is such that the lecithin and amphiphilic block copolymer can sufficiently form a coating film on the surface of fused oil particles of calendula and minimize the amount of water and organic solvent used in the range that they are sufficiently dispersed in water or an organic solvent, So as to minimize the time and cost involved in removing the organic solvent.
The homogenization of the calendula fused oil, lecithin, water homogenized or lecithin coated calendula fused oil, amphiphilic block copolymer, homogenization of the organic solvent can be performed by homomixer, high pressure homogenizer, Homogenization is carried out at 1500 to 3000 rpm for 5 to 15 minutes using a homomixer and homogenization is carried out at a pressure of 100 to 150 bar using a high pressure homogenizer. The drying is preferably performed by using a calendula fused oil component It is preferable to use a freeze-drying method in order to prevent it from being destroyed.
In the calendula fused oil capsules prepared as described above, lecithin and an amphiphilic block copolymer sequentially form a coating film on the surface of calendula fused oil particles, and the coating film is formed from calendula fibrin oil capsules from external factors such as heat, It protects the fused oil and prevents the calendula component from volatilizing because it does not easily deteriorate even after long-term storage of the soap containing fused oil of calendula, so that the reduction of the content during storage is suppressed and the effect of calendula fused oil It is maintained continuously.
Further, since the lipophilic block of the amphiphilic block copolymer is externally oriented, it is uniformly dispersed in an oil-in-oil oil, so that it is uniformly dispersed in a liquid oil in the saponification reaction and is bound to the oil to be saponified When soap is combined with water, calendula fused oil is not washed out in water and can act on the human skin together with soap bubbles. Therefore, the natural physiological activity of calendula fused oil is exerted on the skin More can be given.
In addition, lecithin, which acts as a barrier for calendula fused oil, helps prevent brain damage and reduces cholesterol levels in the blood, thereby helping to prevent myocardial infarction and helping to prevent aging. With calendula fused oil, Effect.
The calendula fused oil capsules are added in an amount of 0.5-3.0 parts by weight based on 100 parts by weight of the oil used in the soap base. If the content is less than 0.5 parts by weight, the calendula effect is not sufficiently imparted to the manufactured soap. The detergency is decreased and the soap is receded and the formability is lowered.
Next, a mixture of oil, sodium hydroxide solution and calendula fused oil capsules, which has been saponified, is poured into a mold and solidified at a temperature of 40 to 55 ° C for 20 to 30 hours to solidify. Then, the mixture is cut to a size suitable for use, The soap is dried at a temperature of 20 to 50 ° C and a relative humidity of 25 to 35% for 40 to 50 days.
Hereinafter, the present invention will be described in more detail with reference to the following examples, comparative examples and test examples.
It is to be understood, however, that the invention is not to be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Will be apparent to those skilled in the art to which the present invention pertains.
<Examples>
The petal of calendula was picked up, cleaned and dried naturally, then put into a glass bottle with vitamin E, and poured the jojoba oil.
The glass bottle was placed in a sunny sunshine and kept for two weeks while shaking it daily, followed by filtration to remove the solids, thereby obtaining calendula fused oil.
70 g of the above-mentioned calendula fused oil and 140 g of lecithin extracted from soybean were mixed with 1 kg of water and homogenized at 2000 rpm for 10 minutes using a homomixer MARK II Model 2.5 using a homomixer. Then, a microfludger M-110F) at 120 bar, and the homogenized mixture was dried in a freeze dryer at -35 DEG C under a vacuum of 20 torr to form lecithin on the surface of the fused oil particles of calendula to form a wall material Respectively.
Next, 70 g of calendula fused oil coated with lecithin on the surface and 140 g of polyethylene glycol-polycaprolactone were mixed with 1 kg of ethanol, homogenized and dried in the same manner as above to prepare lecithin And a polyethylene glycol-polycaprolactone coating film were formed.
Next, 2.2 kg of a sodium hydroxide aqueous solution having a concentration of 50% by weight was slowly poured into 1.2 kg of purified water to prepare an aqueous solution of sodium hydroxide having a sodium hydroxide content of 32% by weight, followed by cooling to 45 캜.
7.5 kg of olive oil was heated to 45 캜 and placed in a mixing container equipped with a stirrer. The stirrer was operated, and 3.4 kg of an aqueous sodium hydroxide solution cooled at 45 캜 was mixed. After 2 minutes from mixing, the calendula fused 100 g of oil capsules were placed in the mixing vessel.
After 3 hours from mixing, it was confirmed that the mixture was converted to the trace state. The mixture was poured into a molding mold, allowed to stand at a warming temperature of 48 ° C for 1 day, solidified, and cut to a size suitable for use.
The cut solidified product was dried for 6 weeks at a temperature of 25 캜 and a relative humidity of 30% to prepare a soap containing calendula fused oil.
≪ Comparative Example 1 &
In the above example, a soap was prepared in the same manner as in the above example, except that the fused oil of calendula in which solids had been removed was put into a mixing vessel without being encapsulated with lecithin and polyethylene glycol-polycaprolactone.
≪ Comparative Example 2 &
In the above example, except that the calendula fused oil capsules were not put in the middle of the progress of the saponification, and 3 hours after the mixing of the olive oil and the aqueous sodium hydroxide solution, the saponification was completed and then the calendula fused oil capsules were mixed , Soaps were produced in the same manner as in the above Examples.
≪ Comparative Example 3 &
In the above example, a soap was prepared in the same manner as in the above example, except that the mixing container was not mixed with the calendula fused oil capsules and only the olive oil and the aqueous sodium hydroxide solution were mixed and saponified.
Test Example 1 Evaluation of appearance stability of soap
In order to confirm the stability of the soap prepared in the above Examples and Comparative Examples 1 to 3, the manufactured soap was stored at 5 ° C, 25 ° C, 45 ° C and daylight condition, and then the appearance change And the results are shown in Table 1 below.
As shown in Table 1, when the soaps were stored under various conditions and observed changes over time, Comparative Example 3, in which calendula fused oil capsules were not mixed at a high temperature of 45 ° C, was first discolored, but after four weeks Comparative Example 1 in which non-encapsulated calendula fused oil was mixed was also discolored and turned to an extent similar to Comparative Example 3.
The antimicrobial and antioxidant activity of calendula prevented the deterioration of soap at the initial stage of storage, but as time passed, the components exhibiting antimicrobial and antioxidant properties of calendula were volatilized in a high temperature environment, and these functions were deteriorated. Residual components of calendula remained discolored and released rapidly It is judged to have proceeded.
In Example 2 and Comparative Example 2 in which calendula fused oil was encapsulated and added to soap, some discoloration occurred only in a high temperature environment, and in order to add the efficacy of calendula to soap, calendula fused oil was encapsulated, It is understood that protecting from external factors such as light and oxygen is preferable in terms of improving storage stability.
<Test Example 2> Skin irritation test
30 persons without skin disease were subjected to a patch test of the soap prepared in the above Examples and Comparative Examples, and the results are shown in Table 2 below.
The samples were soaked at 45 ° C. for 4 weeks in the above Test Example 1. The soap was dissolved in sterilized water as much as possible to prepare a soap solution. Finn Chamber (SmartPractice Co., Ltd.) having a diameter of 8 mm , USA) was applied dropwise after 15 ㎕ each.
The inner part of the upper left part of the subject was wiped with 70% ethanol and dried. Then, the prepared Finn chambers were sealed and attached for 24 hours. Then, the patches were removed and marking areas were marked with a marking pen. After 48 hours, the test site was observed.
According to the criteria of the International Contact Dermatitis Research Group (ICDRG), the degree of skin irritation was classified, and the mean score was calculated according to the average skin response calculation formula. Respectively.
(+ Score × number of subjects) + (+ score × number of subjects) + (+ score × number of subjects) + (++ score × number of subjects) Number of subjects to be examined)} / (maximum stimulus value x total number of subjects x evaluation number) x 100
Note 3) Judgment: 0.00 to 0.75 (no irritation), 0.76 to 1.50 (irritation), 1.51 to 2.50 (irritation), 2.51 to 4.00 (irritation)
As shown in Table 2, the mean scores of Examples and Comparative Examples 1 and 3 were 0.74 and 0.56, respectively, and non-stimulation was judged to be 1.48 in Comparative Example 2. Thus, soaps of each group were stored at a high temperature for a long period of time The stimulus to the skin showed a slight level.
≪ Test Example 3 >
In order to evaluate the antioxidant activity, the DPPH free radical scavenging activity test for the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical of the soap prepared in Examples and Comparative Examples was carried out by the following method Respectively.
DPPH radical scavenging activity was measured by reducing power of DPPH radical in soap, and 0.4 mM solution was prepared by dissolving DPPH in ethanol.
Each soap and 0.4 mM DPPH solution (100 μl) were added to a 96-well plate and incubated at 37 ° C for 30 minutes. Then, an ELISA reader Absorbance at 517 nm was measured.
The DPPH free radical scavenging activity (%) of the soap was calculated using distilled water instead of soap as a control, using the following equation.
DPPH free radical scavenging activity (%) = {1- (absorbance of sample / absorbance of control)} x 100
As shown in Table 3, the antioxidant activity of the mixed calendula component and the comparative examples 1 and 2 was higher than that of the comparative example 3 in which the calendula components were not mixed, but the comparative examples 1 and 2 in which calendula fused oil was not encapsulated 1 showed a lower level of antioxidative activity than the case of encapsulating calendula fused oil and Comparative Example 2.
This indicates that the antioxidant activity of the calendula component improves the antioxidative activity of the soap, but if it is not encapsulated in the calendula fused oil, it deteriorates or is volatilized or removed during storage to lower its efficacy.
≪ Test Example 4 >
Human normal fibroblasts were cultured in a 12-well plate incubator at a concentration of 1 x 10 5 , treated with LPS (lipopolysaccharide), and each of the soaps prepared in the above Examples and Comparative Examples was bubbled with purified water to prepare a soap The components were contained at a concentration of 500 ppm, and then human normal fibroblasts treated with the LPS were cultured.
On the second day of culture, the cells were harvested and the amounts of tumor necrosis factor alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) induced by Western blotting were quantitatively determined, and calendula fused oil capsules Was compared with the rest of the measured values based on 100 as a percentage.
In Table 4, in Comparative Example 2, when the fused oil capsules were mixed after the saponification was completed, the fused oil capsules of calendula were sufficiently bonded to the soap-based ingredients Comparative Example 1 As the non-encapsulated water-soluble calendula fused oil was dissolved in the purified water and was not contained in the foam, the amount of inflammation induced was slightly higher than that of Comparative Example 2, Respectively.
As described above, the calendula fused oil-containing soap of the present invention is produced by coating calendula fused oil particles with lecithin and an amphiphilic block copolymer to protect the calendula component from external factors such as heat, light and oxygen, Even when stored for a long time, the effect of addition of calendula is continuously maintained and the deterioration is suppressed and there is no irritation to the skin. The calendula fused oil capsule is uniformly dispersed in the soap and combined with the soap base component, Can be exerted more.
Claims (7)
0.5 to 3.0 parts by weight of a calendula fused oil capsule containing calendula fused oil contained in a wall material composed of lecithin and an amphiphilic block copolymer and saponifying the mixture when 100 to 150 seconds elapse after the mixing;
Pouring the mixture of the saponified oil, aqueous sodium hydroxide solution and calendula fused oil capsules into a mold, allowing the mixture to stand at 40 to 55 ° C for 20 to 30 hours to solidify; And
And drying the solidified mixture at a temperature of 20 to 50 DEG C and a relative humidity of 25 to 35% for 40 to 50 days.
Wherein the oil is at least one selected from the group consisting of olive oil, castor oil, camellia oil, evening oil, palm oil, coconut oil, palm oil, palm kernel oil, sunflower oil, grape seed oil, soybean oil, rice bran oil, A method for producing a soap containing calendula fused oil.
Wherein the mixing temperature of the oil and the aqueous sodium hydroxide solution is 40 to 50 占 폚, respectively.
The calendula-fused oil capsules may contain,
Mixing and homogenizing 5 to 10 parts by weight of calendula fused oil and 10 to 20 parts by weight of lecithin in 100 parts by weight of water;
Drying the homogenized water, calendula fused oil and lecithin to coat lecithin on the surface of the calendula fused oil particles;
Mixing and homogenizing 5 to 10 parts by weight of calendula fused oil coated with lecithin and 10 to 20 parts by weight of an amphiphilic block copolymer in 100 parts by weight of an organic solvent; And
Drying the homogenized organic solvent, lecithin-coated calendula fused oil and amphiphilic block copolymer to sequentially coat lecithin and an amphiphilic block copolymer on the surface of calendula fused oil, and By weight, based on the total weight of the soap.
Wherein the amphiphilic block copolymer is polyethylene glycol-polycaprolactone, methoxypolyethylene glycol-polycaprolactone, poloxamer, or poloxarane.
Wherein the organic solvent is methanol, ethanol, acetone, tetrahydrofuran, dimethylformamide or dimethylsulfoxide. 9. The process according to claim 1, wherein the organic solvent is methanol, ethanol, acetone, tetrahydrofuran, dimethylformamide or dimethylsulfoxide.
Priority Applications (1)
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| KR1020150044916A KR20160116733A (en) | 2015-03-31 | 2015-03-31 | Soap Containing Calendula Infused Oil, and Method for Manufacturing the Same |
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| KR1020150044916A KR20160116733A (en) | 2015-03-31 | 2015-03-31 | Soap Containing Calendula Infused Oil, and Method for Manufacturing the Same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180061830A (en) * | 2016-11-30 | 2018-06-08 | 김성재 | Soap composition for relieving the symptoms of atopic dermatitis |
| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| WO2023022288A1 (en) * | 2021-08-18 | 2023-02-23 | 천약선 주식회사 | Method for preparing cosmetic composition containing calendula-infused oil and plant mixture extract as active ingredients for moisturizing skin |
| US11931331B2 (en) | 2018-07-27 | 2024-03-19 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
-
2015
- 2015-03-31 KR KR1020150044916A patent/KR20160116733A/en not_active Application Discontinuation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180061830A (en) * | 2016-11-30 | 2018-06-08 | 김성재 | Soap composition for relieving the symptoms of atopic dermatitis |
| KR101869918B1 (en) * | 2016-11-30 | 2018-07-20 | 김성재 | Soap composition for relieving the symptoms of atopic dermatitis |
| US11806327B2 (en) | 2018-07-27 | 2023-11-07 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11931331B2 (en) | 2018-07-27 | 2024-03-19 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
| WO2023022288A1 (en) * | 2021-08-18 | 2023-02-23 | 천약선 주식회사 | Method for preparing cosmetic composition containing calendula-infused oil and plant mixture extract as active ingredients for moisturizing skin |
| KR20230026702A (en) * | 2021-08-18 | 2023-02-27 | 천약선 주식회사 | Cosmetic composition comprising infused oils of calendular and mixed extracts of plants for moisturizing skin |
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