KR20180061830A - Soap composition for relieving the symptoms of atopic dermatitis - Google Patents

Abstract

The present invention relates to soap for alleviating atopic dermatitis. More particularly, the present invention relates to soap which comprises a plant extract alleviating symptoms of atopic dermatitis, wherein the plant extract is nano-encapsulated to prevent oxidation and thermal destruction of active ingredients, thereby maintaining long-term efficacy. The plant extract is extracted from white sandalwood, chamomile, calendula, evening primrose, usnea, Asiatic Pennywort, aloe vera leaves and Portulaca oleracea.

Description

Soap composition for relieving the symptoms of atopic dermatitis

The present invention relates to atopic dermatitis soaps.

Atopy refers to an allergic reaction in which the body becomes extremely sensitive without touching allergic antigens. It is a term derived from the ancient Greek word 'atopia' which means 'strange, abnormal' It is called atopic dermatitis.

Atopic dermatitis is a chronic, recurrent inflammatory skin disease that usually starts in infancy or childhood. It is accompanied by characteristic eczema, such as pruritus (itching) and dry skin, which tends to improve naturally in most cases.

The cause of atopic dermatitis has not been known yet, and the clinical symptoms are various due to dry skin and eczema. Therefore, the causes of atopic dermatitis can not be explained by any one one but environmental factors, genetic predisposition, immunity And the skin barrier is considered to be the main cause.

Environmental factors include environmental pollution caused by industrialization, increase in the use of food additives, increase in use of carpet, bed, sofa due to western type of residence, cause of allergy such as house dust mite due to rise of room temperature (allergen ). Also, it is caused by exposure to the causative substances as the number of pets is increased in the room.

The surface of the skin is divided into the epidermal layer and the dermal layer. The epidermal layer is composed of multiple stratum corneum and protects against external stimuli. However, the skin of the patient having atopic dermatitis does not smoothly exfoliate, Because of this, sebum and waste products in pores can not be released, causing bacteria to naturally cause acne.

In order to alleviate the symptom of atopic dermatitis, a moisturizing composition may be used to induce allergic symptoms of atopic dermatitis, to remove an exacerbation factor, or to prevent dryness of the skin. The chemical agent for treatment includes corticosteroids, immunomodulators, Antihistamines are used to treat modulators and itching. Among these, chemical agents are effective for temporary symptom relief, but they are accompanied by side effects such as resistance to long-term use and skin irritation.

Meanwhile, atopic dermatitis is easily stimulated by soaps, detergents, chemicals, clothing materials, temperature and humidity. Of these, soap and detergent, which are essential in daily life, .

Accordingly, attempts have been made to treat and prevent atopic dermatitis from natural substances. Typical prior arts include atopic dermatitis cosmetic composition (Korean Patent No. 10-0377262), and atopic skin cosmetic composition (Korean Patent No. 10- 0517465), a composition for preventing or treating atopic dermatitis and a method for producing the same (Korean Patent No. 10-0483539), a therapeutic agent for atopic dermatosis containing herbs and a method for producing the same (Korean Patent No. 10-0597997 ).

The patent document includes extracts and ingredients known to have characteristics such as hypo-stimulation and anti-inflammation, but merely a mixture thereof, and is a limit that does not take into consideration the oxidation and denaturation of the extract, which may occur in the production or storage of soap and composition .

Most of the common soap production methods are expected to have the effect of simply mixing natural extracts and extracts effective for specific symptoms. In the soap manufacturing process, the oxidation of natural extracts by heat and chemical components is minimized and long-term efficacy can be maintained Soap and composition are not presented.

Korean Patent Registration No. 10-0377262 (cosmetic composition for atopic skin containing mugwort extract) Korean Patent Registration No. 10-0517465 (herbal cosmetic composition for atopic skin) Korean Patent Registration No. 10-0483539 (Composition for preventing or treating atopic dermatitis and method for producing the same) Korean Patent Registration No. 10-0597997 (therapeutic agent for atopic skin diseases containing herbs and method for producing the same)

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a soap which is capable of maintaining long-term efficacy by inhibiting oxidation and heat destruction of an effective substance by nano-encapsulating a plant extract for alleviating atopic dermatitis symptoms .

In order to solve the above problems, the atopic dermatitis soap of the present invention is characterized in that the atopic dermatitis relieving plant extract is carried on a nanocapsule.

The atopic dermatitis relieving plant extract is characterized in that it is extracted from sandalwood, chamomile, calendula, evening primrose, earthy, cinnabar, aloe vera leaves and marigold.

The atopic dermatitis relieving plant extract is characterized by extracting sandalwood, chamomile, calendula, evening primrose, earthy, cinnabar, aloe vera leaves and marigolds using a supercritical extraction method.

Wherein the atopic dermatitis relieving plant extract comprises 0.1 to 15% by weight of sandalwood, 0.1 to 15% by weight of camomile, 0.1 to 15% by weight of calendula, 0.1 to 15% by weight of evening primrose, 0.1 to 15% From 0.1 to 15% by weight of alfalfa seedlings, from 0.1 to 15% by weight of aloe vera leaves and from 0.1 to 15% by weight of marigolds.

The nanocapsule is characterized in that the nanocapsule is manufactured by carrying an atopic dermatitis plant extract on a porous carrier and spray coating the surface of the porous carrier with a cereal mixed coating liquid.

Wherein the grain-mixing coating solution comprises at least one grain powder selected from the group consisting of barley, corn and soybean; An enzyme solution containing mugwort and noni; vegetable oil; And a polyol.

The nanocapsules are characterized by having an average particle diameter of 10 to 500 nm.

As described above, the atopic dermatitis soap according to the present invention includes a plant extract that alleviates the symptoms of atopic dermatitis, and it is nano-encapsulated to prevent oxidization and thermal destruction of an effective substance to maintain long-term efficacy .

Specific features and advantages of the present invention will be described in detail below with reference to the accompanying drawings. The detailed description of the functions and configurations of the present invention will be omitted if it is determined that the gist of the present invention may be unnecessarily blurred.

The atopic loosening soap according to the present invention comprises atopic loosening botanical extracts extracted from sandalwood, chamomile, calendula, evening primrose, earth lily, clover, aloe vera leaves, and marjoram, wherein the plant extract is supported on nanocapsules, And is characterized by preventing denaturation and oxidation.

The characteristics of the atopic dermatitis relief plant are as follows.

Sandalwood contains a large amount of α-santalol, which is antiviral and anticancer effective, and phenolic compounds, which are antioxidants. It is known that scent unique to sandalwood activates skin renewal by activating the olfactory receptors in the skin.

Chamomile It has an excellent effect to improve the damaged capillaries, to soothe dryness and itching, and it strengthens the skin cells and increases the elasticity of the skin.

Calendula is excellent in skin regeneration, wound healing, antioxidant effects, and contains a large amount of complex polysaccharides that promote the immune response. Saponins, flavonoids, and carotene in calendula are excellent for promoting cell regeneration and preventing bacterial and fungal infections.

Evening primrose is rich in gamma linolenic acid, a type of omega-6 fatty acid, which is effective against atopic dermatitis by reducing inflammation and inhibiting allergic reactions.

Earthia contains a large amount of usinic acid, and it is excellent in skin immunity activity and skin soothing effect. In addition, it plays a role of a natural preservative without skin irritation and toxicity, and enables long-term storage of soap.

The bedspread Madeca is an effective ingredient for healing wounds, promoting blood circulation, preventing wrinkles. In particular, it enhances collagen production and replacement function, and gives skin elasticity and health. In addition, it is effective in the treatment of itching, eczema and other anti-inflammation, and also acts to inhibit bacillus bacteria that cause leprosy and skin tumors.

Aloe vera leaves contain a large amount of polysaccharides to enhance immune function, promote skin regeneration, and maintain skin moisturizing power. In addition, it has an excellent sedative effect against rashes such as dryness and skin burning.

Machi Hyun is said to be excellent in many aspects such as skin soothing, anti-inflammation and antibacterial, convergence, and moisturizing effects.

In addition, the atopic dermatitis relieving plant may further include an anti-inflammatory plant in addition to those listed above. The anti-inflammatory plant is a plant having an anti-inflammatory activity, and includes at least one selected from the group consisting of acanthopanax oleic acid, Gold, cottonwood, safflower, and combinations thereof.

Magnolia Bark has been used as a raw material mainly used in oriental medicine, but it has recently been proved to have excellent effect on antibacterial action against acne inflammation, acne relief and sebum control in skin inflammation. It has also been confirmed that antimicrobial activity against pathogenic Vibrio bacteria and purulent yellow staphylococci, which are food poisoning causative bacteria, and phytoncide, a useful physiologically active substance, are contained in large amounts.

Forsythia viridissima is a fruit of Forsythiaviridissima L. belonging to Oleaceae. Its active ingredient is actinin as a lignan, arctin as a lignan glycoside and caffeic acid glycoside ), And the like. It is known that the antioxidant and anti-inflammatory activity of the allium is utilized to effectively inhibit the bacterium. In addition, it inhibits the production of free fatty acid by decomposition of the sebum component by the antioxidative activity, And it is known that it has an effect of relieving inflammation and erythema symptoms by anti-inflammatory activity.

Dandelion has an effect of preventing oxidative stress of skin due to its ability to protect against active oxygen which causes skin aging.

Omija contains a compound of lignan, a vegetable estrogen, and has the effect of inhibiting the inflammatory reaction which is the main cause of skin damage and aging.

Drumstick tree contains antioxidant substances such as antioxidant, antioxidant phenolic compounds and flavonoids known to have antioxidant, anti-inflammatory, anticancer, antiallergic and other physiological activities, thus having skin inflammation inhibition and skin healing effect.

The crude oil is a pharmacological component and its root contains tannin and triterpenoid saponin. Branches contain quercetin and kaempferol glycosides, ursol acid, And vitamin C in flowers, chrysanthemin and cyanin in flowers 10). They are known to be excellent for treating inflammation such as dermatitis, mucositis and eczema.

Gold is human-friendly, has broad antibacterial activity against Gram positive group and Gram negative group, and has stability against heat and pH, providing environment that bacteria can not easily reproduce.

Cottonwood contains a large amount of antimicrobial substances called terpenes, is known to have excellent antimicrobial and bactericidal action against bacteria.

Safflower is a fruit of Asteraceae, is known to promote blood circulation, detoxification and anti-inflammatory effect.

The method for obtaining the extract from the atopic dermatitis relieving plant is not limited, For example, a solvent, such as water, an anhydrous or a lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate or 1,3-butylene glycol, may be added under a predetermined temperature and pressure condition ) Compression extraction, hot water extraction, room temperature extraction, warming extraction, ultrasonic extraction, supercritical extraction and the like.

In order to maximize the extractability, the supercritical extraction method or the supersonic extraction method using carbon dioxide and / or high temperature may be used. The supercritical extraction method refers to supercritical fluid extraction, The critical fluid has the properties of liquid and gas when the gas reaches the critical point at high temperature and high pressure, and has chemically similar polarity to the non-polar solvent. Due to this characteristic, the supercritical fluid is used to extract the lipophilic material .

Carbon dioxide is a supercritical fluid with both liquid and gaseous nature, with the operation of supercritical fluid equipment reaching its critical pressure and temperature, resulting in increased solubility in fat-soluble solutes. When supercritical carbon dioxide passes through an extraction vessel containing a certain amount of sample, the lipophilic substance contained in the sample is extracted into supercritical carbon dioxide.

When the supernatant carbon dioxide containing a small amount of solvent is passed through the sample remaining in the extraction vessel after extracting the fat-soluble substance, components that have not been extracted by pure supercritical carbon dioxide can be extracted.

The supercritical fluid used in the supercritical extraction method of the present invention can effectively extract an active ingredient by using a mixed fluid in which supercritical carbon dioxide or carbon dioxide is further mixed with a solvent. These solvents may be used alone or in admixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane and diethyl ether.

Most of the extracted samples contain carbon dioxide, which is volatilized into air at room temperature, and the solvent can be removed with a reduced pressure evaporator.

Ultrasonic extraction is a method of extracting an object to be extracted by applying ultrasonic waves. As the extraction solvent, one or a mixture of two or more selected from the group consisting of chloroform, ethanol, methanol, water, ethyl acetate, hexane and diethyl ether can be used .

The extracted sample is recovered by vacuum filtration, and the filtrate is recovered, and the extract is removed by a vacuum evaporator and freeze-dried to obtain an extract.

At this time, when extracting from the atopic dermatitis relieving plant using the above-mentioned extraction method, the plant can be extracted by putting it in a solvent in a living state, but in order to further increase the extraction rate, dried and nano- It is possible to maximize the extraction efficiency by widening the contact surface area.

Wherein the atopic dermatitis relieving plant extract comprises 0.1 to 15% by weight of sandalwood, 0.1 to 15% by weight of camomile, 0.1 to 15% by weight of calendula, 0.1 to 15% by weight of evening primrose, 0.1 to 15% 0.1 to 15% by weight of alfalfa seedlings, 0.1 to 15% by weight of aloe vera leaves, and 0.1 to 15% by weight of marigolds, respectively.

The atopic loosening plant extract obtained as described above prevents heat denaturation and chemical denaturation caused by heat and pH change in the soap making process and oxidation of the active ingredient generated during soap storage process, Are held on the nanocapsules so that they can be maintained for a long period of time.

At this time, the nanocapsules are prepared by carrying a plant extract of atopic dermatitis on a porous carrier, spraying a cereal mixed coating solution, and coating the surface of the porous carrier.

The porous carrier is a structure having a plurality of pores. The material is not limited as long as it is human-friendly, and for example, alginic acid, silica, squalane and the like can be used.

The porous carrier carrying the atopic dermatitis plant extract is coated on the surface by the cereal mixed coating solution so that the nano-pulverized extract can not be easily eluted from the pores of the surface.

The grain-mixing coating solution is prepared by mixing a grain powder, an enzyme solution, a vegetable oil, and a polyol. More specifically, 20 to 30% by weight of grain powder, 10 to 20% %, Vegetable oil 10 to 20 wt%, and polyol 30 to 40 wt%.

The grain powder is characterized in that it is selected from barley, corn and soybeans. The barley, corn and soybeans are superior in nutritional quality to other grains and do not contain gluten blocking the skin pores. Can be minimized.

Barley is rich in beta-glucan and vitamins, and is excellent in skin regeneration. It is also rich in calcium and potassium to strengthen skin barrier and help maintain skin's moisture and pH balance.

Lecithin, which is contained in soy, gives the skin shine, and isoflavones are known to be excellent for preventing skin aging.

The corn contains a large amount of protein. Zein, a storage protein material extracted from corn, has excellent film-forming ability, high affinity for human body and stability, and is used as a control agent for controlling the release rate of a drug.

The enzyme solution is an enzyme solution prepared by using mugwort and noni, which can reduce the toxicity contained in unprocessed natural products and can impart the efficacy of mugwort and noni.

The antioxidant effect of mugwort is excellent. Especially, eucalyptol, which is one of the components of mugwort, has a specific effect on atopy salts, and alpha pyrene and pyrroline have anti-inflammatory action, and atemicinin has an inhibitory action on skin sensitization . It is preferable to use the young leaves collected in the morning of winter in the present invention because the winter mugwort is excellent in the mildew and is not toxic to the mugwort collected in the morning. Also, it is preferable to remove the root of the mugwort since it contains a camper having toxicity.

Noni is a fruit native to the tropics. It contains about 140 kinds of nutrients such as calcium and vitamins and 200 types of phytochemicals. It is known that progesterone activates normal cells and makes damaged cells healthy cells. It also protects skin barrier damage caused by ultraviolet rays, including flavonoids, tannins, and saponins, and calms erythema Excellent.

The above-mentioned dog mugwort and noni enzyme solution are prepared by aging 25 to 40% of sugar, 60 to 75% of non-mugwort sugar and noni at temperatures of 15 to 20 ° C for 180 days or more, An enzyme solution can be used. In the case of the mixed enzyme solution, it can be prepared by mixing dog mugwort and noni at a weight ratio of 1: 1.

The vegetable oil is added to impart a predetermined viscosity to the cereal-mixed coating solution, and the type of the vegetable oil is not limited. Specific examples thereof include castor oil, coconut oil, and olive oil.

The polyol is used as a dispersion medium and may be used as a dispersant in a solvent such as sorbitol, polyethyleneglycol, polypropylene glycol, dipropylene glycol, propyleneglycol, But are not limited to, those selected from the group including 1,3-butylene glycol, glycerine, propanediol, ETHYL HEXANEDIOL, and pentyleneglycol. Do not.

The grain mixing coating solution can be coated on the surface of the carrier using an injection coating method. At this time, the spraying pressure can be 1.5 to 3 kg / cm 2. If the spray pressure is less than 1.5 kg / cm 2, The size of the capsule after coating is increased. When the amount exceeds 3 kg / cm < 2 >, the grain coating liquid is finely sprayed, which may take a lot of time in the coating process.

Further, after the coating, the drying step may further include drying at 1 to 48 hours at 25 to 35 DEG C, so that the grain-mixed coating liquid can be more adsorbed and fixed on the carrier.

The nanocapsules have an average particle diameter of 10 to 500 nm. Coagulation may occur if the nanocapsule is less than 10 nm. If the nanocapsule is more than 500 nm, it is difficult to absorb the nanocapsules. .

 Hereinafter, a method for producing an atopic dermatitis soap comprising nanocapsules carrying an atopic dermatitis relieving plant extract will be described.

The method of manufacturing an atopy mitigation soap according to the present invention includes a first mixture forming step (S100) of forming a first mixture by adding a nanocapsule having an atopic dermatitis relieving plant extract to a molten soap base and stirring the mixture, A second mixture forming step (S200) of mixing the essential oils to form a second mixture, and a third maintaining step (S300) in which the second mixture is kept in a soap mold and aged by keeping warming.

In the first mixture forming step (S100) The nanocapsules containing the atopic dermatitis relieving plant extract are added to the molten soap base and stirred to form a first mixture. More specifically, the nanocapsules are added in an amount of 5 to 20% by weight based on 100% by weight of the molten soap base Mixed.

If the nanocapsules are added in an amount of less than 5% by weight based on 100% by weight of the molten soap base, the effect is insignificant. If the nanocapsules are more than 20% by weight, the increase in the content of the nanocapsules is insignificant, It is preferable that the temperature does not deviate from the above range.

The soap base is not limited as long as it is a conventionally usable soap base, for example, a soap base for Melt and Pour (MP), which can be used by melting a previously prepared soap base, a mixture of oil, caustic soda and purified water A soap base for CP (cold process), and a soap base for HP (hot process) which mixes caustic soda water with oil and is heated at a high temperature.

At this time, the method and temperature for melting the soap base are based on the preferred method and temperature for the soap base used. For example, the soap base for MP is 50 to 85 DEG C, the soap base for CP is 50 to 60 DEG C, The soap base melts at 70-90 < 0 > C.

More preferably, in the present invention, AMP (Advanced Melt and Pour) soap base base, which is a kind of soap base for MP, is used. The AMP soap base base is composed of Soapberry, a natural surfactant, and unsaturated fatty acids (olive oil, (Palm or coconut) and a synthetic surfactant are not included, so that the occurrence of skin troubles can be minimized.

The melting time and stirring speed may vary depending on the nature and content of the soap base used and may be from 10 to 150 rpm for 10 to 30 minutes according to conventional methods.

In the second mixture forming step (S200), the prepared first mixture and the essential oil are mixed to form a second mixture. In more detail, 0.5 to 3% by weight of essential oil And mixed at 50 to 65 ° C.

The essential oil is a highly concentrated essential oil extracted from a plant having a fragrance and plays a role of adding aromatherapy and various skin functional effects.

The type of the essential oil is not limited and specific examples include bergamot, neroli, jasmine, ylang ylang, rosewood, petitgrain, grapefruit, grapefruit, sweet orange, lemon, Frankincense, lavenere, lime, geranium, lemongrass, cedarwood atlantica, Rosemary, peppermint, ginger, juniper berry, marjoram, tea tree, eucalyptus, and the like.

The essential oil is added in an amount of 0.5 to 3% by weight based on 100% by weight of the first mixture. If it is added in an amount of less than 0.5% by weight, the effect is insignificant. If it is added in an amount exceeding 3% by weight, It may be desirable to avoid the above-mentioned range because the side effects such as the deterioration of the soap may be delayed and the deterioration of the soap may be delayed.

If the mixing temperature is less than 50 ° C, the mixing property is deteriorated. If the mixing temperature is higher than 65 ° C, denaturation of the essential oil may occur.

The second mixture is kept at 35 to 55 ° C. for 1 to 3 days by putting the second mixture into a soap mold, And an aging step of separating the molded product from the soap mold and then cutting and aging at 5 to 20 ° C for 3 to 6 weeks.

The keeping step is a step of keeping the molded product at 35 to 55 ° C for 1 to 3 days to uniformly generate the saponification reaction of the second mixture.

At this time, when the temperature is kept below the keeping time and temperature, the saponification reaction occurs unevenly and the pH is high, so that the aging time is prolonged in the post-process aging step. When the temperature is kept above the keeping time and temperature, And rancidity can proceed quickly, so that it is preferable not to deviate from the above range.

In the aging step, the saponification reaction which has not been completed in the warming step is gradually terminated, and at the same time, the moisture is evaporated and solidified with an appropriate soap.

At this time, the aging period and temperature are preferably 5 to 20 ° C for 3 to 6 weeks. If the aging period and the temperature are lower than the above-mentioned aging period and temperature, the skin may be damaged due to a high pH. If the aging period and temperature are exceeded, So that the aging period and the temperature are not exceeded.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be taken as limiting the scope of the present invention. The present invention can be variously modified or modified. The scope of the invention should, therefore, be construed in light of the claims set forth to cover many of such variations.

Claims (7)

Characterized in that it comprises a nanocapsule carrying an atopic dermatitis relieving plant extract
Atopic relief soap.
The method according to claim 1,
The atopic dermatitis relieving plant extract
Sandalwood, calendula, evening primrose, mustard, cinnabar, aloe vera leaves, and marjoram
Atopic relief soap.
3. The method of claim 2,
The atopic dermatitis relieving plant extract
Sandalwood, evening primrose, chamomile, calendula, evening primrose, mustard, cinnabar, aloe vera leaves and marigolds are extracted using a supercritical extraction method
Atopic relief soap.
3. The method of claim 2,
The atopic dermatitis relieving plant extract
0.1 to 15% by weight of calendula, 0.1 to 15% by weight of calendula, 0.1 to 15% by weight of evening primrose, 0.1 to 15% by weight of evening primrose, 0.1 to 15% 0.1 to 15% by weight of aloe vera leaves and 0.1 to 15% by weight of marigolds
Atopic relief soap.
The method according to claim 1,
The nanocapsule
Characterized in that it is produced by carrying an atopic dermatitis plant extract on a porous carrier and spray coating the surface of the porous carrier with a cereal mixed coating liquid
Atopic relief soap.
The method according to claim 6,
The grain-
Cereal powder of any one of barley, corn and soybean; An enzyme solution containing mugwort and noni; vegetable oil; And a polyol.
Atopic relief soap.
The method according to claim 1,
The nanocapsule
Characterized by having an average particle diameter of 10 to 500 nm
Atopic relief soap.