KR20200029981A - Composition for Prevention or Improving of Atopic Dermatitis and manufacturing method thereof - Google Patents

Abstract

A composition for preventing or alleviating atopic dermatitis according to the present invention has effects of treating, alleviating, and preventing skin with atopic dermatitis and can enable prevention and treatment such as anti-inflammatory and antalgic by mixing a Morinda citrifolia extract and a Centella asiatica extract in an optimal content. In addition, the composition according to the present invention maintains the elasticity of the skin and is rich in components such as selenium and terpene, which can remove toxins of cells, to have an effect of preventing not only skin problems such as eczema and ringworm, but also skin aging. Also, the composition of the present invention can provide a variety of formulations such as solutions, gels, emulsions, suspensions, microemulsions, microcapsules, creams, toners, lotions, powders, ointments, sprays, and conceal sticks, to the public at a reasonable price.

Description

Composition for prevention or improvement of atopy and manufacturing method thereof

The present invention relates to a composition for preventing or improving atopy and a method for manufacturing the same, in detail, a composition having natural ingredients such as Noni extract and Cypress extract and having a soothing effect on the skin and at the same time improving or preventing atopy disease will be.

Some ingredients used in topical products are potentially irritating, especially for people with sensitive skin. As an example, hydroxy acids and retinoids have been proven to provide benefits such as improvements in appearance, skin gloss, aging, etc., of photodamaged or naturally aged skin. However, when these ingredients are applied at high concentrations, they may sometimes be associated with skin irritation, for example, skin redness and stinging sensations upon application. Stimulation associated with hydroxy can be reduced by increasing the pH of the composition. The effectiveness of this method decreases as the penetration of hydroxy through the skin decreases.

The appearance, frequency, and nature of stimuli often varies from user to user, but the severity of stimuli for sensitive users can vary from mild to severe. Itching, stinging, burning sensation in normal symptoms of irritation. Tension, tingling, erythema (redness), or swelling (bloating). Environmental conditions such as sunlight, wind, cold and dry air can cause or exacerbate irritation, as well as soaps, cleaners, cleaning products, shaving creams, alcohol and other products that remove protective lipids and secretions from the skin. It may increase the permeability and sensitivity of the skin to topically applied chemicals that may not produce.

In addition to the chemical and environmental causes of skin irritation, many people have an innate sensitivity or genetic trait to skin irritants. Whatever the exact cause of the irritation, many attempts have been made to reduce the irritation potential of topical products by identifying chemicals that tend to cause irritation and removing the components from the product. Unfortunately, it is often not possible or impractical to identify or eliminate all irritating chemicals, especially when the irritating chemical is the active ingredient of the product or is necessary for formulation, preservative or other functional reasons. Therefore, there is a need for research on compositions and methods for preventing or reducing skin irritation.

On the other hand, atopic dermatitis is a chronic, recurrent inflammatory skin disease that usually begins in infancy or childhood, accompanied by itching and dryness characteristic eczema. In infancy, eczema begins on the unfolded side of the face and limbs, but as it grows, it appears characteristically in the form of eczema in the bent area behind the knee and in the bent area behind the knee, and in many cases tends to improve naturally as it grows. see. In adults, folds of skin appear to thicken at the folds, and eczema often occurs on the face compared to infants. The cause of atopy is still unknown. Because clinical symptoms also appear in various ways such as dry skin and eczema, the cause of the onset cannot be explained in any one way, but environmental factors, genetic predisposition, immunological reactions, and abnormalities of the skin protective film are considered to be the main causes. Environmental factors include environmental pollution such as soot caused by industrialization, increased use of food additives, and increased substances causing allergies such as mites caused by the use of carpets, beds, and sofas.

In order to treat such atopy, topical steroids, topical immunomodulators, systemic steroids, systemic immunosuppressants, antihistamines, etc. are usually administered or taken, but these drugs pose a risk of various side effects.

In order to solve such side effects, interest in alternative medical supplementary therapies for drug treatment as described above, and mainly used natural ingredients used as cosmetic raw materials or cosmetic massage products for the treatment of skin diseases, specifically , By applying vegetable aroma oil to the skin, alternative therapies were used to obtain the healing effect of natural essential oils penetrated into the skin, tension relief through the sense of smell, and emotional stability, and in particular, atopic dermatitis using chamomile oil as an active ingredient Although an emollient has been disclosed, the effect of improvement on severe atopy is not remarkable due to its insufficient efficacy.

Republic of Korea Patent Publication 10-2009-0017182 (February 18, 2009)

The present invention has been devised to solve the above-mentioned problems, and specifically, for preventing or improving atopy, which includes natural ingredients such as Noni extract and Cypress extract and has a sedative effect on skin and at the same time improves or prevents atopic diseases. It aims at providing a composition and its manufacturing method.

The present invention relates to a composition for preventing or improving atopy and a method for manufacturing the same.

One aspect of the present invention,

a) Award for preparing a water layer composition by mixing 35 to 50 wt% of Noni extract, 20 to 30 wt% of Centella extract, 5 to 20 wt% of vegetable glycerin, 1 to 10 wt% of alum and 1 to 10 wt% of apricot salt Layer composition preparation step;

b) 30-50% by weight of evening primrose oil, 10-20% by weight of jojoba oil, 10-20% by weight of sweet almond oil, 5-10% by weight of emulsifier, 5-10% by weight of shea butter, and 10-20% by weight of thickener An oil layer composition preparing step of preparing an oil layer composition;

c) a mixture preparation step of mixing the aqueous layer composition and the oil layer composition in a weight ratio of 1 to 2: 1 to 3; And

d) adding essential oil to further mix 1 to 10 parts by weight of essential oil to 100 parts by weight of the mixture;

It relates to a method for producing a composition for preventing or improving atopy, characterized in that it comprises a.

In addition, the emulsifier is olive emulsifying wax, lecithin, monoglyceryl monoglyceryl, monoglyceryl monooleate, diglyceryl monooleate, diglyceryl dioleate, tetraglyceryl monooleate, tetraglyceryl dioleate, monoiso Monoglyceryl stearate, diglyceryl monoisostearate, diglyceryl diisostearate, tetraglyceryl monoisostearate, tetraglyceryl diisostearate, monoglyceryl monostearate, diglyceryl monostearate, di Characterized in that it is one or a plurality of diglyceryl stearate, tetraglyceryl monostearate and tetraglyceryl distearate, and the thickener is gati gum, gum arabic, xanthan gum, guar gum, lecithin, carrageenan, It is characterized in that it is any one or a plurality selected from chitin, pectin and sucrose fatty acid esters.

In addition, the essential oils are eucalyptus (Eucalypus), peppermint (Peppermint), grapefruit (Grapefruit), neroli (Nenolri), nialuli (Niaouli), lavender (Lavender), lime (Lime), lemon (Lemon), lemongrass ( Lemongrass, Melissa officinalis, Rose, Rosemary, Rosewood, Majoram, Citrus madurensis, Myrtle, Myrrh, Basil , Verbena, Birch, Bergamot, Bay, Benzoinum, Cypress, Sandaiwood, Cinnamon, Cedarwood, Citro Citronella, Orange sweet, Ylang ylang, Jasmine, Geranium, Juniper derry, Ginger, Chamomile, Camphor , Clariy sage, Thyme, Tangerine, Tea tree, Palmarosa, Patchouli, Petigrain It is characterized in that the oil is extracted from any one or a plurality of plants selected from tgrain, Frankincense, Fennel and Hyssop.

Another aspect of the present invention relates to a composition for preventing or improving atopy prepared by the above preparation method, wherein the composition is a solution, gel, emulsion, suspension, microemulsion, microcapsule, cream, skin, lotion, powder, ointment, spray And it is characterized in that it has any one or a plurality of formulations selected from a conceal stick (conceal stick).

The composition for preventing or improving atopy according to the present invention has the effect of treating, improving, and preventing atopic skin by mixing the Noni extract and Centella extract in an optimal content, and can be treated and prevented for anti-inflammatory and analgesic.

In addition, the composition according to the present invention maintains the elasticity of the skin and is rich in components such as selenium and terpene to remove toxins from cells, and thus has an effect of preventing skin aging as well as skin troubles such as eczema and ringworm.

In addition, the composition according to the present invention is a variety of formulations, for example, solutions, gels, emulsions, suspensions, microemulsions, microcapsules, creams, skins, lotions, powders, ointments, sprays and conceal sticks to the public at a reasonable price It can be provided.

Hereinafter, a composition for preventing or improving atopy according to the present invention and a method for manufacturing the same, for example and comparative examples will be described in more detail. The following specific examples are provided as examples in order to sufficiently convey the spirit of the present invention to those skilled in the art.

Therefore, the present invention is not limited to the specific examples presented below, but may be embodied in other forms, and the specific examples presented below are only described to clarify the spirit of the present invention, and the present invention is not limited thereto.

At this time, unless there are other definitions in the technical terms and scientific terms to be used, it means that those skilled in the art to which the present invention pertains have the meanings commonly understood, and unnecessarily obscure the subject matter of the present invention in the following description. Descriptions of possible known functions and configurations are omitted.

Also, the singular form used in the specification and the appended claims may be intended to include the plural form unless otherwise indicated in the context.

In the present invention, the term “atopy” means having allergic nature that is inherently sensitive in a dictionary sense, but in the present invention, it is limited to being expressed on the skin among the allergic properties. However, the atopy may be classified into an infant type atopy, a pediatric type atopy, an adult type atopy, and a pregnant woman atopy depending on the expression time and expression target, but the atopy in the present invention is defined to include all of these types of atopy. In addition, the expression form of the atopy may include erythema, dry skin, itchiness, swelling, scab, blisters, and the like.

In the present invention, the term “treatment or prevention” of atopy means not only to alleviate, improve, or heal the symptoms of the atopy, but also to suppress recurrence or expression of atopy.

In the present invention, the term "extract" refers to a substance containing an active ingredient obtained by using a method such as pulverization, hot water, solvent extraction, etc. of the root, leaf, stem, flower, and fruit of the corresponding plant.

Method for preparing a composition for preventing or improving atopy according to the present invention,

a) Award for preparing a water layer composition by mixing 35 to 50 wt% of Noni extract, 20 to 30 wt% of Centella extract, 5 to 20 wt% of vegetable glycerin, 1 to 10 wt% of alum and 1 to 10 wt% of apricot salt Layer composition preparation step;

b) 30-50% by weight of evening primrose oil, 10-20% by weight of jojoba oil, 10-20% by weight of sweet almond oil, 5-10% by weight of emulsifier, 5-10% by weight of shea butter, and 10-20% by weight of thickener An oil layer composition preparing step of preparing an oil layer composition;

c) a mixture preparation step of mixing the aqueous layer composition and the oil layer composition in a weight ratio of 1 to 2: 1 to 3; And

d) adding essential oil to further mix 1 to 10 parts by weight of essential oil to 100 parts by weight of the mixture;

It can be prepared including.

First, in step a), 35 to 50% by weight of Noni extract, 20 to 30% by weight of Centella extract, 5 to 20% by weight of vegetable glycerin, 1 to 10% by weight of alum and 1 to 10% by weight of apricot salt are mixed to form an aqueous layer Can be produced.

In the present invention, the Noni (Morinda citrifolia) is also called a sea wave pole, a wave pole stream, and is a medicinal plant native to Morocco, Indonesia. From around 6000 years ago, Noni's fruits and leaves were used for edible and medicinal purposes, and roots and stems were used for dyeing. In Indonesia, it is called Mend Pace Diva, and it is a medicine that is effective against panacea, and JAMURA is still used as a traditional treatment.

In oriental medicine, the tropical region is considered to have a cold nature of origin, Noni. In particular, in the case of Noni, it has a cold property to withstand the hot heat, and it is believed that this property has an anti-inflammatory effect by lowering the heat of the body, especially the inflammation of the skin.

In addition, the noni contains geronine, a physiologically active substance that functions to enhance protein activity and promote energy metabolism by affecting protein metabolism. This component is known to activate normal cells more and impart regenerative capacity to damaged cells. In addition, Noni contains progeronin, which is a precursor of geronin, in addition, and contains about 160 kinds of beneficial ingredients such as serotonin, alkaloids, glycosides, and enzymes.

The noni may use all components such as roots, stems, leaves, flowers, and fruits, but it is preferable to use fruits. At this time, the fruit of the noni is 8-12 cm and it is preferable to use the harvested when the color changes to white. At this time, the noni fruit has a sugar content of 5-7, and since it is the most abundant alkaloid component that prevents cell aging, the function of the extract can be maximized.

The harvested noni fruit may be washed to remove foreign substances remaining on the surface, and then crushed or hot water extracted using a solvent. At this time, if necessary, the Noni fruit is fermented and aged for 1 to 7 days at room temperature for 45 to 75 hours at a temperature of 20 ± 2 ° C and a humidity of 50 to 60% RH, preferably 60 to 70 hours, thereby inducing an increase in the active ingredient. It is preferred.

The noni extract is preferably added to 35 to 50% by weight, more preferably 38 to 42% by weight relative to 100% by weight of the total aqueous layer composition. When added to less than 35% by weight, the effect of improving atopy, especially the anti-inflammatory effect, may be significantly reduced, and when added to more than 50% by weight, itching or rash may occur due to the strong properties of noni.

The Centella asiatica (L.) Urban, also called the tiger grass, is a hellebore that blooms white or light purple on small fan-shaped leaves with serrated edges. Fruits are small oval, with protruding nets at the ends, usually growing in warm and humid areas.

Books such as Sinnongbongyeonggyeong and Bonchoguwon write that the taste is bitter, very, and very cold, and in oriental medicine, it acts on the liver, spleen, nerves, etc. to reduce heat and discharge moisture, so as to calm and detoxify swelling.

In India, wounded tigers have been used as medicine for a long time because they saw tigers healed and treated in places with many diseased grasses. The Madeira car siksan is an ingredient in the leaves and stems of Centella asiatica heal inflammation, As revealed something that has the power to heal the wounds of such tumors and ulcers sseuyimyeo as a raw material such as ointments and toothpaste, cosmetics, skin flora (Propioni -Bacterium acnes , Staphylococcus aureus ), Staphylococcus epidermidis , Streptococcus pyogenes , etc. ( Zaidan et al. 2005; Taemchuay et al. 2009; Bibi et al. 2011) ; Lalitha et al. 2013; Idris and Nadzir 2017 ).

The bottled grass may use all components such as roots, stems, leaves, flowers, fruits, and the like, but preferably, roots or stems are preferably used. The collected roots or stems are preferably removed by removing soil or impurities, drying at room temperature, and crushing them. Alternatively, hot water may be extracted by using a low-temperature solvent as in the noni.

The centella extract is preferably added in an amount of 20 to 30% by weight, more preferably 25 to 28% by weight, based on 100% by weight of the total aqueous layer composition. When added to less than 20% by weight, the effect of improving atopy, especially itching, scab, and wound healing may be significantly reduced, and when added to more than 30% by weight, rash may occur on the skin due to the cold nature of the screen .

The vegetable glycerin is a natural material used for food, and is triacylglycerol mainly extracted from fruits and seeds of plants. It usually contains unsaturated fatty acids and exists as a liquid at room temperature.

The vegetable glycerin acts as a solvent for dissolving other solid components, and at the same time has moisture retention in itself, thereby suppressing moisture loss of the composition, and can improve stability by suppressing deterioration of the composition even during long-term storage.

In the present invention, the vegetable glycerin is preferably 5 to 20% by weight, more preferably 10 to 15% by weight of 100% by weight of the total aqueous layer composition. When adding less than 5% by weight, the effect of adding vegetable glycerin is insufficient, and when adding more than 20% by weight, the formulation of the composition is limited to a liquid, and processability and applicability may be deteriorated.

The bamboo salt is added as a skin conditioning agent, and the sun salt produced on the west coast of Korea is placed in a bamboo barrel grown for more than 3 years and heated nine times over 1,000 ° C. This raw material has a function of detoxifying, sterilizing, clotting, and anti-inflammatory effects in the body to improve the skin and clear the complexion, thereby suppressing the occurrence of acne, swelling, and blemishes.

The bamboo salt is preferably added to 1 to 10% by weight of 100% by weight of the total aqueous layer composition. When added in less than 1% by weight, the same effect as anti-inflammatory effect is not exhibited. When added in excess of 10% by weight, the anti-inflammatory effect of Noni and Centella can be weakened due to the warm properties of salt.

The alum (Alum) has the formula of AlNH ₄ (SO ₄ ) ₂ · 12H ₂ O, aluminum sulfate, alkali metal ammonium, sulfate, and the like, and converging action to relieve itching. The alum acts topically on the skin or mucous membranes to coagulate proteins to remove inflammation and protect the skin by creating a coating, which has the effect of preventing bacterial infection.

The alum may be added as it is, but after heating, it is preferable to cool at a temperature of 20 to 25 ° C for 10 to 12 hours.

The alum is preferably added to 1 to 10% by weight of 100% by weight of the total aqueous layer composition. When added in less than 1% by weight, the anti-inflammatory effect is insignificant, and when added in excess of 10% by weight, the cold properties of the composition are strengthened, so that a rash may appear on the skin.

The aqueous layer composition is a noni extract, bottled water extract, gujil salt, alum and citric anhydride are put in a container and heated to a temperature of about 40 ° C for about 10 minutes to melt the gel-like aqueous layer material, and then stirred to increase the viscosity. It is good.

Next, 30 to 50% by weight of evening primrose oil, 10 to 20% by weight of jojoba oil, 10 to 20% by weight of sweet almond oil, 5 to 10% by weight of emulsifier, 5 to 10% by weight of shea butter, and thickener 10 as in step b) It is possible to prepare an oily layer composition by mixing to 20% by weight.

The evening primrose oil is milked from the seeds of the evening primrose, and the name of the herbal medicine is called wolhahyang, wolmyeoncho, yaraehyang. The taste is sweet, the properties are warm, it is known to strengthen the musculoskeletal effect and eliminate wind and moist. In addition, it is known that it is especially good for women due to its high content of gamma-linolenic acid and healing physiological impurity, and has the effect of preventing thrombus and promoting blood circulation. In particular, it has the effect of preventing aging, strengthening the immune system and improving atopy skin.

The evening primrose oil is preferably added to 30 to 50% by weight, more preferably 43 to 47% by weight compared to 100% by weight of the total oil layer composition. In case of adding less than 30% by weight, the effect of improving atopy is insufficient, and when adding more than 50% by weight, inflammation may be expressed due to excessive addition of gamma-linolenic acid.

The jojoba oil (jojoba oil) is a liquid ester oil obtained from the seeds of jojoba is excellent in terms of stability and texture, and is widely used as an oil base material mainly in basic cosmetics. The jojoba oil as described above is less oily than other vegetable oils, and has a structure of wax ester, which is a component of sebum, so it is easy to familiarize with the skin and mixed with Noni and folding screen By neutralizing the strong properties of shinoni and folding screen, their side effects can be suppressed.

In the present invention, the jojoba oil is preferably 10 to 20% by weight, more preferably 14 to 17% by weight compared to 100% by weight of the total oil layer composition. When less than 10% by weight is added, the effect of adding jojoba oil is insufficient, and when it is added more than 20% by weight, the content of other active ingredients is reduced and the balance of the overall composition may be collapsed.

The sweet almond oil is a natural vegetable oil extracted from sweet almonds and contains vitamins A, D, E and unsaturated fatty acids linoleic acid and oleic acid, especially the content of the oleic acid (about 70 to 80%). Content), and has excellent skin conditioning effect and high skin penetration. In addition, since it contains anti-inflammatory components and antioxidants, it acts to protect the skin from ultraviolet rays, and, like jojoba oil, neutralizes the strong properties of Noni and folding screens to relieve itching and inflammation, so it is effective for dry skin. to be.

The sweet almond oil is preferably 10 to 20% by weight, more preferably 14 to 17% by weight compared to 100% by weight of the total oil layer composition. When less than 10% by weight is added, the effect of adding sweet almond oil is insufficient, and when more than 20% by weight is added, the content of other active ingredients is reduced, and the balance of the overall composition may be collapsed.

The emulsifier forms a thick and stable gel, has the effect of maintaining the moisturizing power of the entire composition and imparting an excellent feeling of use in the formulation.

The emulsifier is not limited to the type as long as it is conventionally used in the art, it is preferable to use a natural emulsifier. Examples of the natural emulsifier include lecithin and olive emulsifying wax, and in addition, monoglyceryl monoglyceryl, monoglyceryl monooleate, diglyceryl monooleate, diglyceryl dioleate, tetraglyceryl monooleate, di Tetraglyceryl oleate, monoglyceryl monoisostearate, diglyceryl monoisostearate, diglyceryl diisostearate, tetraglyceryl monoisostearate, tetraglyceryl diisostearate, monoglyceryl monostearate, Glyceryls such as diglyceryl monostearate, diglyceryl distearate, tetraglyceryl monostearate, and tetraglyceryl distearate may be used, and among these, lecithin or olive oil wax is preferable.

In particular, the lecithin is a natural emulsifier used in a wide range of formulations such as essences, lotions, creams, etc., because it is more skin-friendly than any other emulsifier and has excellent usability and emulsifying power, and effectively forms a liquid crystal structure similar to that of the skin, effectively delivering skin to the skin. It is known to have an effect of increasing SPF of sun products and preventing aging.

The emulsifier is preferably added 5 to 10% by weight of 100% by weight of the total oil layer composition. When adding less than 5% by weight, the aqueous phase layer composition and the oily layer composition may not be properly mixed, and phase separation may occur. When adding more than 10% by weight, the amount of active ingredient other than the emulsifier is reduced, so that the effect of improving atopy may be insufficient. have.

The shea butter contains vitamin A, D, E, F, and more natural fatty acids than other natural plants, and is a fat component extracted from small fruits such as almonds, softens the skin, and helps moisturize, soften, and regenerate It is known to give.

The shea butter may be added in 5 to 10% by weight of 100% by weight of the total composition. When adding less than 5% by weight, the moisturizing effect of the composition is insufficient, and when adding more than 10% by weight, the amount of other active ingredients added decreases, so the effect of improving atopy may be insufficient.

The thickener is for maintaining the formulation of the entire composition, and can be used without being limited to the type as long as it is conventionally added in the art. Examples of the thickener include beads wax, gati gum, gum arabic, xanthan gum, guar gum, lecithin, carrageenan, chitin, pectin, and sucrose fatty acid esters. These can be added alone or by adding a plurality of thickeners It is also okay.

The thickener is preferably added to 10 to 20% by weight of 100% by weight of the total composition. If it is outside the above-mentioned range, it is difficult to maintain the formulation of the composition, and layer separation of the aqueous layer composition and the oil layer composition may occur.

The oily layer composition is put into a container, and evening primrose oil, castor oil, emulsifier, shea butter and thickener are added and heated to a temperature of about 70 ° C. to gel. At this time, when the temperature of the aqueous layer composition is higher than the temperature of the oily layer composition, mixing is easy, so it is good to adjust the temperature or adjust the heating time.

Next, a mixture may be prepared by mixing the aqueous layer composition and the oil layer composition. At this time, the mixture is better mixed when the temperature of the aqueous layer composition is higher than the temperature of the oil layer composition as described above, so it is good to adjust the heating time of each composition in consideration of this.

It is good to pour the oil layer composition into the aqueous layer composition several times. This is because the phase separation may occur when the oil layer composition is added at once, and the adhesion between the skin and the composition may be deteriorated.

The mixture is preferably mixed with the water layer composition and the oil layer composition in a weight ratio of 1 to 2: 1 to 3, more preferably, the water layer composition and the oil layer composition are mixed in a weight ratio of 1 to 1 to 2. This is because, in addition to enhancing the adhesion to the skin, side effects such as skin problems may occur when the amount of the aqueous layer composition is increased due to the strong properties of the Noni extract and the Centella extract contained in the aqueous layer composition.

After mixing the aqueous layer composition and the oil layer composition, it is preferable to emulsify using a stirrer. The stirring speed at the time of emulsification is not limited in the present invention, and preferably, maintaining a stirring speed of 50 to 500 rpm can prevent excessive solidification of the mixture.

The mixture is preferably cooled to 40 ° C or lower. This is to prevent the destruction of the components of additives such as essential oils added later and to maximize emulsification.

The mixture prepared as above may be mixed with an essential oil to prepare a composition for preventing or improving atopy.

The essential oil refers to a highly concentrated essential oil extracted from a plant having a fragrance and serves to add antibacterial and various skin functional effects, including aroma effect, with the fragrance of soap.

Examples of the essential oils include Eucalyptus, Peppermint, Grapefruit, Neroli, Niaouli, Lavender, Lime, Lemon, Lemongrass (Lemongrass), Melissa officinalis, Rose, Rosemary, Rosewood, Majoram, Citrus madurensis, Myrtle, Myrrh, Basil ), Verbena, Birch, Bergamot, Bay, Benzoinum, Cypress, Sandaiwood, Cinnamon, Cedarwood, Sheet Citronella, Orange sweet, Ylang ylang, Jasmine, Geranium, Juniper berry, Ginger, Chamomile, Camphor ), Clariy sage, Thyme, Tangerine, Tea tree, Palmarosa, Patchouli, Petigrain (P) etitgrain), Frankincense, Fennel and Hyssop, etc. These may be used alone or in combination of two or more plurals.

More preferably, eucalyptus or peppermint is added as the essential oil.

The eucalyptus (Eucalyptus globulus) is an evergreen tree called an Australian rubber tree or a koala tree, and contains various essential oils in various streamlines on the leaves. Extracts are obtained from the leaves and twigs of eucalyptus. As an extraction method, steam distillation is usually used, and a method of rectifying in a vacuum at a low temperature is also used to increase the content of cineol. The eucalyptus exhibits antibacterial and anti-inflammatory properties, strengthens the circulatory system, and clears the head to enhance concentration.

In addition, the peppermint (peppermint) is a perennial plant belonging to the genus Nepaceae of the dicotyledonous plant, and is a hybrid of spearmint and watermint, a type of peppermint. Peppermint, with its refreshing scent and cool taste, was widely used as a fragrance and fragrance, as well as edible and medicinal, even in the days of ancient Egypt and Rome. Menthol contained in peppermint has strong antimicrobial properties, removes inflammation of the skin, relieves various skin troubles, and has an excellent effect in improving skin itching caused by allergies.

In addition, the essential oil may further include a moisturizing agent such as hyaluronic acid, a natural preservative such as propolis, woody skin, gold, etc., in addition to the eucalyptus or peppermint, and they do not limit the amount of addition, but when the essential oil is prepared, the eucalyptus or When adding in the form of a mixture of peppermint, it is preferable to mix eucalyptus or peppermint in a weight ratio of 1 to 3 compared to 1 weight ratio, respectively. This is to keep the peppermint refreshing feeling in an optimal range in addition to the sterilizing effect of the essential oil.

The essential oil is not limited to the amount of addition, but it is preferable to add 1 to 10 jungrang parts compared to 100 parts by weight of the whole mixture, since it is possible to improve formulation maintenance, enhance the effectiveness of active ingredients, and improve applicability.

In addition to the above components, the composition for preventing or improving atopy according to the present invention may further add an auxiliary agent commonly used in the art in a conventional content. Fatty substances, organic solvents, solubilizers, gelling agents, emollients, antioxidants, suspending agents, stabilizers, fragrances (flavors), surfactants, emulsifiers, fillers, thickeners, inorganic salts, preservatives, moisturizers, vitamins, blockers , Wetting agents, dyes, and the like, and these may be added alone or in combination of two or more.

The present invention includes a composition for preventing or improving atopy prepared by the above manufacturing method. In this case, the composition may have any one or a plurality of formulations selected from solutions, gels, emulsions, suspensions, microemulsions, microcapsules, creams, skins, lotions, powders, ointments, sprays and conceal sticks, It can be prepared in various forms depending on the use of the composition.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the following examples and comparative examples are merely illustrative of the present invention, and it is apparent to those skilled in the art that various changes and modifications are possible within the scope of the present invention and the scope of the technical idea. Of course it belongs to.

Test examples of the specimens prepared through Examples and Comparative Examples are as follows.

(Antibacterial)

After inoculating Petri dish with Staphylococcus aureus, a skin flora, it was cultured for 3 days. After applying 1 ml of the composition prepared through Examples and Comparative Examples, the number of colonies of the bacteria was measured after 24 hours, and the antibacterial rate was calculated based on the number of bacteria after 24 hours compared to the initial number of bacteria.

(Anti-inflammatory)

The present invention for suppressing thermal erythema caused by overexposure to infrared rays and actinic erythema caused by overexposure to ultraviolet rays to measure the sedative effect on different inflammations depending on the type of irritation applied to the skin The effect of the composition was tested. Volunteers experimented with a panel of 10 women between the ages of 22 and 59 and 10 men between the ages of 10 and 29.

The anti-inflammatory sedative effect was counted by measuring subcutaneous vascular blood circulation, skin erythema color and skin temperature. Subcutaneous capillary blood circulation was specified by a heat conduction measuring device (Hematron). When the capillaries contract, the conductivity decreases and when they expand, they increase. The decrease in inflammation is an indication that the swelling is not reduced by the contraction of the expanded capillaries. Meanwhile, the skin erythema color was measured using a Minolta CR300 chromatometer, and the skin temperature was also measured using Hematron.

The infrared irradiator used for the induction of hot erythema was IR Phillips 250 S, and the irradiation intensity was 70 mW / cm 2 and irradiated at a distance of 50 cm for 30 minutes to induce hot erythema. The irradiation site was 14 cm 2. The ultraviolet irradiation was irradiated to a 4 cm 2 area with a 100W intensity using a UV irradiation device (SUNTEST / ORIGINAL HANAU) equipped with a Xenon lamp. The minimum inflammatory incidence dose (MED: Minimal Erythemal Dose) for each volunteer was determined and then examined. The inflammatory soothing effect by the composition of the present invention was measured 24 hours after irradiation with ultraviolet rays.

(Sensory test)

Twenty adult male and female subjects (Group A) with oily skin, 20 adult male and female subjects with dry skin (Group B), and 20 children, adolescent and adult subjects with Atopic skin (Group C). Subjects were tested. After the specimens of Examples and Comparative Examples were applied twice a day for 1 month, the following evaluation items were evaluated. The evaluation was performed on a 5-point scale (1: very bad, 2: bad, 3: moderate, 4: good, 5: very good). At this time, in the case of evaluation of stimulation, it was expressed as the number of subjects feeling stimulation.

(Example 1)

Noni 42% by weight, 28% by weight of bottleweed, 14% by weight of vegetable glycerin, 8% by weight of alum and 8% by weight of apricot salt were added to a container and heated at 40 ° C for 10 minutes to prepare an aqueous layer composition. After completion of the production, the aqueous layer composition was cooled at room temperature.

Next, evening primrose oil 38% by weight, jojoba oil 15% by weight, sweet almond oil 15% by weight, soy lecithin 8.5% by weight as an emulsifier, and 15% by weight of bees wax as a thickener were added to the container and then at 70 ° C for 10 minutes. Heated. When the contents of the container were completely dissolved, 8.5% by weight of shea butter was added and gradually melted to prepare an oily layer composition. The finished oily layer composition was cooled at room temperature.

And after mixing the aqueous layer composition and the oil layer composition in a mixing ratio of 1: 1, hyaluronic acid and natural preservatives (trade name: Phyto PS, The Witch) peppermint oil compared to 100 parts by weight of the mixture, respectively, 1: 1: 1 weight ratio 3 parts by weight of the essential oil mixed with and solidified at room temperature to prepare a cream-shaped composition for improving atopy. The physical properties of the prepared specimens were measured and described in Tables 3 to 6 below.

(Examples 2 to 7 and Comparative Examples 1 to 5)

A specimen was prepared in the same manner as in Example 1, but the amount of the composition added during specimen production was added as shown in Table 1 or Table 2. The physical properties of the prepared specimens were measured and described in Table 1 below.

[Table 1]

[Table 2]

(In Tables 1 and 2, the aqueous layer and oil layer compositions are weight%, and the essence oil means parts by weight.)

[Table 3]

[Table 4]

[Table 5]

[Table 6]

(In Tables 4 to 6, subjective stimulation means itching, pulling, burning, and objective stimulation means blistering, erythema, and cracking.)

As shown in Tables 3 to 6, it can be seen that the composition for preventing or improving atopy prepared according to the present invention has antimicrobial properties and has an excellent effect of improving erythema, itching, and blisters, which are the main symptoms of atopic dermatitis. However, it can be seen that when the added amount of the main components such as Noni, Cypress, Evening Primrose, Jojoba Oil and Sweet Almond Oil increases over a certain level, the irritation to the skin increases, indicating that the composition ratio of the present invention has a stable effect.

In particular, it can be seen that Comparative Example 1, in which bottle extract was added over a certain period, received a poor score in the subjective stimulus and objective stimulus categories, and the effect of improving the stimulus was also lowered in Comparative Example 2, in which evening primrose oil was excessively added. In addition, Comparative Example 3 in which the aqueous layer was added more than the oily layer was found to be irritated to the skin due to the increase in the amount of Noni and Centella, and Comparative Example 4 in which the content of peppermint constituting the essential oil was out of a certain range also It was found that atopic disease worsened due to excessive cooling sensation. In addition, it can be seen that Comparative Example 5, in which no bottled extract was added to the aqueous layer composition, had an insufficient antimicrobial effect of the composition, and thus the inhibitory effect of the skin flora was poor.

 The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and variations without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical spirit of the present invention, but to explain, and the scope of the technical spirit of the present invention is not limited by these embodiments. The scope of protection of the present invention should be interpreted by the claims below, and all technical spirits within the scope equivalent thereto should be interpreted as being included in the scope of the present invention.

Claims (5)

a) Award for preparing a water layer composition by mixing 35 to 50 wt% of Noni extract, 20 to 30 wt% of Centella extract, 5 to 20 wt% of vegetable glycerin, 1 to 10 wt% of alum and 1 to 10 wt% of apricot salt Layer composition preparation step;
b) 30-50% by weight of evening primrose oil, 10-20% by weight of jojoba oil, 10-20% by weight of sweet almond oil, 5-10% by weight of emulsifier, 5-10% by weight of shea butter, and 10-20% by weight of thickener An oil layer composition preparation step of preparing an oil layer composition;
c) a mixture preparation step of mixing the aqueous layer composition and the oil layer composition in a weight ratio of 1 to 2: 1 to 3; And
d) adding essential oil to further mix 1 to 10 parts by weight of essential oil to 100 parts by weight of the mixture;
Method for producing a composition for preventing or improving atopy, characterized in that it comprises a.
According to claim 1,
The emulsifier is olive emulsified wax, lecithin, monoglyceryl monomyristate, monoglyceryl monooleate, diglyceryl monooleate, diglyceryl dioleate, tetraglyceryl monooleate, tetraglyceryl dioleate, monoisosteare Acid monoglyceryl, diglyceryl monoisostearate, diglyceryl diisostearate, tetraglyceryl monoisostearate, tetraglyceryl diisostearate, monoglyceryl monostearate, diglyceryl monostearate, disteaar Method for preparing or preventing atopy composition, characterized in that it is one or more selected from acid diglyceryl, tetraglyceryl monostearate and tetraglyceryl distearate.
According to claim 1,
The thickener is any one or a plurality of selected from beads wax, gumi gum, gum arabic, xanthan gum, guar gum, lecithin, carrageenan, chitin, pectin, and sucrose fatty acid esters.
According to claim 1,
The essential oils are Eucalyptus, Peppermint, Grapefruit, Neroli, Niaouli, Lavender, Lime, Lemongrass ), Melissa officinalis, Rose, Rosemary, Rosewood, Majoram, Citrus madurensis, Myrtle, Myrrh, Basil, Verbena, Birch, Bergamot, Bay, Benzoinum, Cypress, Sandaiwood, Cinnamon, Cedarwood, Citronella (Citronella), Orange sweet, Ylang ylang, Jasmine, Geranium, Juniper berry, Ginger, Chamomile, Camper, Clariy sage, thyme, tangerine, tea tree, palmarosa, patchouli, petitgrain , Frankincense (Frankincense), Fennel (Fennel) and hyssop (Hyssop) selected from any one or a plurality of plants extracted oil characterized in that the method for preventing or improving atopy composition.
A composition for preventing or improving atopy prepared by a manufacturing method according to any one of claims 1 to 4, wherein the composition is a solution, gel, emulsion, suspension, microemulsion, microcapsule, cream, skin, lotion , Powder, ointment, spray and a composition for preventing or improving atopy, characterized in that it has any one or a plurality of formulations selected from conceal sticks.