KR101732906B1 - Skin care and atopic dermatitis cosmetic compositions containing asiatic pennywort extract, magnolia bark extract, hiba arborvitae branch extract, eucalyptus oil and borage seed oil - Google Patents

Abstract

The present invention relates to a cosmetic composition which is excellent in skin-soothing effect and has an effect of improving atopy without side effects due to the inclusion of natural substances such as centaury extract, Magnolia bark extract, Nahlia berry extract, Eucalyptus oil and Borage seed oil.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a cosmetic composition for skin soothing and atopic amelioration, which comprises extracts of Kukkwulp, Magnolia bark extract, Nahliaceae extract, Eucalyptus leaf oil and Borage seed oil as active ingredients. BRANCH EXTRACT, EUCALYPTUS OIL AND BORAGE SEED OIL}

The present invention relates to a cosmetic composition wherein the main component having atopic effect as well as a soothing effect of the skin is a plant extract and a vegetable oil.

Some ingredients used in topical products are potentially irritating to people with particularly sensitive skin. As an example, hydroxy acids and retinoids have been shown to provide benefits such as improved appearance in photodegraded or naturally aged skin, skin gloss, aging, and the like. However, these components can sometimes be associated with skin irritation, for example, skin rash and stinging sensation when applied at high concentrations. The stimulation associated with hydroxy can be reduced by increasing the pH of the composition. This method reduces efficacy as the penetration of hydroxy through the skin decreases.

The appearance, frequency, and properties of stimuli are often user-specific, and the severity of stimuli for sensitive users may vary from mild to severe. Typical symptoms of irritation include itching, stinging, burning sensation. Tension, tingling, erythema (redness), or swelling (swelling). Environmental conditions such as sunlight, wind, cold, and dry air can irritate or aggravate, and other products that remove soap, detergents, cleaning products, shaving creams, alcohol, and protective lipids and secretions from the skin can irritate Lt; RTI ID = 0.0 > and / or < / RTI > the topically applied chemical that may not be able to form the skin.

Similarly, the skin may be irritated by infection, shaving scratches, repeated or excessive washing or bathing, exposure to sunlight, or other mechanical scratches or damage.

 In addition to the chemical and environmental causes of skin irritation, many people have inherent sensitivities or genetic predisposition to skin irritants. Whatever the exact cause of the irritation, there have been many attempts to identify the chemicals that are prone to irritation and to reduce the irritation potential of topical products by removing them from the product. Unfortunately, it is often not feasible or practical to identify all of the irritating chemicals, especially when the irritating chemicals are the active ingredients of the product or are needed for reasons of formulation, preservative or other functionality. Therefore, there is a need for studies on compositions and methods for preventing or reducing skin irritation.

Atopic dermatitis, on the other hand, is a chronic, recurrent, inflammatory skin disease that usually begins in infancy or childhood, with itching and dry skin characterized by eczema. In infancy, it begins with eczema on the spreading part of the face and limbs, but as it grows, it appears in the form of eczema on the part where the arm bends and on the bending part behind the knee. In many cases, it tends to improve naturally see. In adults, a thickening of the folding skin appears, and eczema often occurs on the face compared to the pediatric period. The cause of atopy is not known yet. Clinical symptoms vary widely from dry skin to eczema, so the cause of the disease can not be explained by any one single factor, but environmental factors, genetic predisposition, immunological reactions, and skin barrier abnormalities are considered to be the major causes. Environmental factors include environmental pollution due to industrialization, increase in the use of food additives, and an increase in allergenic substances such as mites caused by use of carpets, beds, and sofas.

 It is a perennial plant that blooms white or light purple flowers on small fan-shaped leaves with jagged edges. The fruit is a small oval, with a net that protrudes from the end. It grows in warm and humid areas.

In India, a wounded tiger has been used for a long time, calling it a tiger grass, seeing it healing in a place where it is plentiful. It is found that the ingredient Madeca in the leaves and stalks of the centipedes is effective in healing inflammation and healing of wounds such as tumors and ulcers. It is also used as a raw material for ointments, toothpaste, and cosmetics.

Magnolia is a deciduous tree with magnolia and is also called god. Magnolia flower peaks and flower buds are known to be effective against arteriosclerosis and sinusitis, and bark is used as a fragrance, and it is known to be effective for pestilence and headache.

Hanbaek is an evergreen needlework tree planted with ornamental plants. It is used as a building material and soil wood. It is reported that the essential oil of Hanwa is antimicrobial, and the mechanism of antimicrobial effect of hinokitiol isolated from Hanwa is reported, and the leaf has been reported to protect the liver.

Eucalyptus is distributed in the sub - tropical highlands by the amount of plating. Eucalyptus is a Greek word for beauty and overcoat. It is derived from the shape of a flower. The oil has a strong sterilizing action, so it is effective in cleansing and cleansing the skin. It is also effective in relieving stress and relieving stress, and diluted oil is applied to chest on sputum. It has been used since the ancient Egyptian era to maintain the youthful skin. It has a cooling effect on hot sunburned skin and has an insecticidal effect.

Borage is a dental dentist, which is derived from the Latin bristles. Borage was born at the beginning of the year, and the ancients praised it for its effectiveness as an antidepressant. It is also effective against eczema and skin diseases, diuretic, sweating. It is pointed out that the components of leaves and seeds increase the amount of milk because they affect the hormones. Recently, a high concentration of gamma-linolenic acid in seeds has been discovered and can be helpful in many diseases. The consumption of barley seed oil, which is extracted from seeds, is increasing with massage oils and cosmetic creams. Leaves and flowers are used as a nourishing agent to make your skin soft and clean and help relieve tension in your mind and body.

The plant extracts are disclosed in Patent Documents 10-2003-0024932 and the cosmetic compositions containing the extracts of Centaurea mushrooms, and the extract of Magnolia bark is disclosed in the cosmetics for improving acne of Patent Application No. 10-2010-0089409 , And Bacillus thuringiensis extracts are disclosed in Japanese Patent Laid-Open No. 10-2009-00385890 and in cosmetic compositions for acne skin containing white oil, and Eucalyptus leaf oil and Borage seed oil are disclosed in Patent Document 10-2013-00664660 .

However, there are no inventions that exhibit the synergistic effect by applying the above-mentioned five materials at the same time, and the best synergy effect of each content has not yet been found.

The present invention relates to a skin protecting composition and an atopic remedy composition effective for skin soothing and skin irritation mitigation when applied topically to the skin.

The above-described object of the present invention is achieved by providing a cosmetic composition effective for skin soothing and skin irritation alleviation comprising a centilla extract, Magnolia bark extract, Bark extract, Eucalyptus leaf oil and Borage seed oil.

According to a preferred feature of the present invention, 2% by weight of the centilla sprout extract, 1% by weight of the Magnolia bark extract, 2% by weight of the bark extract, 0.1% by weight of the eucalyptus leaf oil, and 0.5% by weight of the barley seed oil.

According to a preferred feature of the present invention, the formulation of the composition is one of a softening agent, a convergent lotion, a nutritional lotion, an essence, a nutritional cream, a massage cream, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray and a powder.

When the cosmetic composition which is effective for relieving the skin and alleviating skin irritation, which comprises the centilla annulus extract, Magnolia bark extract, Nahan bark extract, Eucalyptus leaf oil and Borage seed oil complex as active ingredients, is applied to the skin according to the present invention, Helps to restore skin.

1 is a cytotoxicity graph of the composition according to Example 1 of the present invention using RAW 264.7 cells in Experimental Example 1. FIG.
2 is a graph showing the NO production inhibitory effect of the composition according to Example 1 of the present invention using RAW 264.7 cells in Experimental Example 2. FIG.
3 is a cytotoxicity graph of the composition according to Example 2 of the present invention using RAW 264.7 cells in Experimental Example 1. FIG.
4 is a graph showing the NO production inhibitory effect of the composition according to Example 2 of the present invention using RAW 264.7 cells in Experimental Example 2. FIG.
FIG. 5 is a cytotoxicity graph of the composition according to Example 2 of the present invention using RBL-2H3 cells in Experimental Example 3. FIG.
6 is a graph showing the effect of inhibiting β-hexosaminidase activity of the composition according to Example 2 of the present invention using RBL-2H3 cells in Experimental Example 4. FIG.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments of the invention are shown. These embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. , And this does not mean that the technical idea and scope of the present invention are limited.

The cosmetic composition according to one embodiment of the present invention includes the functional ingredients of centilla extract, Magnolia bark extract, Nagoya berry extract, Eucalyptus leaf oil and Borage seed oil complex.

In the cosmetic composition according to an embodiment of the present invention, when the functional ingredients are contained in an amount of less than 0.1% by weight, the main function of the composition is difficult to manifest. When the content of the functional ingredients is less than 10% by weight, the formulation stability is poor, It is preferably added in an amount of 0.1 to 10% by weight each.

The cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention is not particularly limited in its formulation and may be applied to cosmetic preparations such as a skin cosmetic type cosmetic composition, a solution, a suspension, an emulsion, But are not limited to, pastes, gels, creams, lotions, ointments, patches, powders, soaps, surfactant-containing cleansers, oils, powder foundations, emulsion foundations, waxes foundations, sprays, More specifically, it can have formulations such as softening lotion, convergent lotion, nutritional lotion, eye cream, nutritional cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, pack, essence and the like.

In addition, other ingredients other than the above-mentioned effective ingredients may be blended into the cosmetic composition for skin soothing and atopic dermatitis of each formulation according to the formulation or purpose of use of other cosmetics. The skin-soothing cosmetic composition according to an embodiment of the present invention may be added with a base component that can be compounded with a generally known cosmetic composition for skin administration.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to one embodiment of the present invention is paste, cream or gel, it is preferable to use animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol Silica, talc or zinc oxide, titanium oxide and the like may be added.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention is bar diesel, in addition to the above-mentioned effective ingredients, there may be mentioned carbomers, triethanolamine, menthol, Ethanol, glycerin, disodium iodide, methylparaben, fragrance and the like may be added.

Herein, the carbomer and triethanolamine function as a gradual agent, the menthol functions as a fragrance component, the ethanol functions to give a cooling sensation, the glycerin serves as a moisturizing agent, and the disodium is dithiene, And methylparaben is added to function as a preservative.

Various fragrances such as a herb flavor and the like other than the menthol flavor may be added at the time of manufacturing the cosmetic composition for skin soothing and atopy improvement according to an embodiment of the present invention.

In addition to the above-mentioned specific ingredients, it is also within the scope of the present invention to apply the known substances widely used in the art to achieve the functions of the thickener, refreshing feeling, fragrance ingredient, Will be included.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention is a powder or a spray (spray), lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder And, in the case of a spray, in particular, propellants such as chlorofluorohydrocarbons, propane / butane or dimethyl ether may be included.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is added as a carrier component. Examples thereof include water, ethanol, isopropanol, Ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to one embodiment of the present invention is a suspension, the carrier component may be a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, polyoxyethylene sorbitol Suspending agents such as esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be added.

When the formulation of the cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention is a surfactant-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, Aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters, may be added to the composition of the present invention. have.

In addition, the cosmetic composition for skin soothing and atopic dermatitis according to an embodiment of the present invention may be prepared from compositions such as bar diesel, body lotion, body cream, and body oil for promoting fat decomposition in addition to usual additives. , And aerosol type. In this case, it is preferable that the cosmetic material having a skin soothing effect according to an embodiment of the present invention is used as a transdermal method of applying or spraying directly on the skin.

In addition, the amount of the cosmetic composition for skin soothing and atopic dermatitis according to one embodiment of the present invention can be suitably adjusted according to individual differences, formulations, and forms such as the age and condition of skin fat, Can be effectively used as cosmetics, medicines, or quasi-drugs for calming skin.

Hereinafter, the composition of the present invention will be described in more detail through examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

Example 1: Preparation of compositions for skin soothing and atopic dermatitis according to one embodiment of the present invention

First, a bedspread, a magnolia bark, and a hundred kinds of bark were secured, washed with purified water, the water was sufficiently removed with a clean tissue, and dried in a dryer at 60 ° C for 2 days. Each dried material was pulverized, 1 kg of powder was put into a container, 40 L of purified water was added, and the mixture was subjected to hot water extraction at 90 to 120 캜 for 48 hours. After the extraction, the mixture was filtered through a filter paper to remove solid components, and the resulting dried extract was filtered through a rotary evaporator to concentrate the concentrate to a high concentration. The concentrate was frozen at -70 ° C to completely evaporate water through a freeze- .

The three extracts were dissolved in purified water at a concentration of 1 g / mL and mixed.

Experimental Example 1: Cytotoxicity in the macrophage (RAW 264.7) of Example 1 [

To examine the cytotoxicity of the compositions according to one embodiment of the present invention, RAW 264.7 cells were treated with the respective compositions obtained in Examples 1-1 to 1-8. RAW 264.7 cells were cultured in the ATCC (American Type Culture Collection). Each cell was inoculated into a 24-well culture plate at a concentration of 1 × 10 ⁴ cells / ml. The medium was DMEM (Dubelco's Modified Eagle Medium, GIBCO, USA) containing 1% penicillin-streptomycin (P / S) and 10% FBS. After culturing for 24 hours in DMEM containing 10% FBS and culturing to 50% of the culture vessel surface area, the composition prepared in Example 1 was replaced with 10% FBS / DMEM containing 1% and further cultured for 24 hours. After the incubation, 50 쨉 l of a solution of 3- (4,5-dimethylthiazole) -2,5-diphenyltetrazolium bromide (MTT, Sigma M5655, USA) solution (4 mg / ml) After the supernatant was removed, 200 μl of dimethylsulfoxide (DMSO, Sigma D2650, USA) solution was added to each well. The formazan crystals were dissolved by stirring for 20 minutes. absorbance at 570 nm. The survival rate of the skin cells was calculated by the following equation (1) based on the absorbance of the control group using purified water and expressed as a percentage. The results are shown in FIG.

As shown in FIG. 1, when the composition according to one embodiment of the present invention was treated, cytotoxicity was not observed. As shown in FIG. 1, the cytotoxicity of RAW264.7 cells was not observed.

Experimental Example 2: NO inhibitory effect experiment of Example 1

In order to examine the NO production inhibitory effect of the composition according to one embodiment of the present invention produced in each of the Examples, RAW 264.7 cells were treated with the respective compositions obtained in Examples 1-1 to 1-8. RAW 264.7 cells were cultured in the ATCC (American Type Culture Collection). Each cell was inoculated into a 6-well culture plate at a concentration of 1 × 10 ⁵ cells / ml. The medium was DMEM (Dubelco's Modified Eagle Medium, GIBCO, USA) containing 1% penicillin-streptomycin (P / S) and 10% FBS. The cells were cultured in DMEM containing 10% FBS for 24 hours, and the composition prepared in Example 1 was replaced with 10% FBS / DMEM containing 1%, followed by further treatment with lipopolysaccharide (hereinafter referred to as LPS) to 100 ng / And cultured for another 24 hours. The NO concentration in the culture medium was measured by adding Griess reagent to the cell culture medium. 100 μL of cell culture solution and 100 μL of Griess reagent were mixed and reacted for 10 minutes in a 96-well plate. Absorbance was measured at 540 nm, and a standard curve was obtained using sodium nitrite and the NO production value was calculated. The results were as shown in Fig.

As shown in FIG. 2, when the composition according to one embodiment of the present invention was treated, the extracts of Kunchuk extract, Magnolia bark extract, and Nago haploid extract were mixed at a ratio of 2: 1: 2 Was found to exert an excellent toxic effect.

Example 2: Preparation of a composition for skin-soothing and atopic dermatitis, in which an oil was added to Example 1 of the present invention

Eucalyptus leaf oil and borage seed oil are obtained by washing the raw material with purified water, and the raw material is heated in distilled water. The distillate generated at this time is cooled and collected, and the water layer and the oil layer are fractionated to obtain only an oil layer.

The two oils were dissolved and mixed at the concentration in Example 1-6, which showed the best effect in Example 1, and the mixture was as shown in the following table.

The effect of the above example was the same as that of Experimental Example 1 and Experimental Example 2. As a result, as shown in FIG. 3, there was no cytotoxicity in Example 2, and the NO production inhibitory effect was shown in Eucalyptus oil, : 0.5 ratio was the most excellent effect (FIG. 4).

Experimental Example 3: Cytotoxic effect on mast cell (RBL-2H3) of Example 2

RBL-2H3 cells were treated with the respective compositions obtained in Examples 2-1 to 2-9 in order to examine the NO production inhibitory effect of the composition according to one embodiment of the present invention produced in the Examples. RBL-2H3 cells were cultured in an ATCC (American Type Culture Collection). Each cell was inoculated into a 24-well culture plate at a concentration of 1 × 10 ⁴ cells / ml. The medium was DMEM (Dubelco's Modified Eagle Medium, GIBCO, USA) containing 1% penicillin-streptomycin (P / S) and 10% FBS. After culturing for 24 hours in DMEM containing 10% FBS and culturing to 50% of the culture vessel surface area, the composition prepared in Example 1 was replaced with 10% FBS / DMEM containing 1% and further cultured for 24 hours. After the incubation, 50 쨉 l of a solution of 3- (4,5-dimethylthiazole) -2,5-diphenyltetrazolium bromide (MTT, Sigma M5655, USA) solution (4 mg / ml) After the supernatant was removed, 200 μl of dimethylsulfoxide (DMSO, Sigma D2650, USA) solution was added to each well. The formazan crystals were dissolved by stirring for 20 minutes. absorbance at 570 nm. The degree of survival of skin cells was calculated by the following equation (1) based on the absorbance of the control group using purified water and expressed as a percentage. The results are shown in FIG.

As shown in FIG. 5, when the composition according to one embodiment of the present invention was treated, the cytotoxicity of the composition containing eucalyptus at a high concentration . However, it was confirmed that the other compositions did not show cytotoxicity.

Experimental Example 4: Inhibitory effect of β-hexosaminidase on mast cell (RBL-2H3) of Example 2

RBL-2H3 cells were treated with each of the compositions obtained in Examples 2-1 to 2-9 to examine the inhibitory effect of β-hexosaminidase on the composition according to one embodiment of the present invention. RBL-2H3 cells were plated at 2.5 × 10 5 cells / well in a 24-well plate and cultured for 12 hours in MEM medium containing 20 ng / ㎖ of DNP-specific IgE. The experiments were carried out in PIPES buffer (25 mM PIPES, pH 7.2, 159 mM NaCl, 5 mM KCl, 0.4 mM MgCl ₂ , 1 mM CaCl ₂ , 5.6 mM glucose, 0.1% fatty acid-free fraction V from bovine serum , The process is as follows. After washing twice with PIPES buffer, the sample to be tested was diluted with each concentration and reacted for 30 minutes. The cells were then stimulated with 25 ng / ml DNP-BSA (antigen) for 10 min, and then placed on ice for 5 min to stop the reaction. The cells were then centrifuged at 1,000 rpm for 5 min. The cells remaining on the plate were lysed with 0.1% Triton X-100. The supernatant and dissolved cell samples were mixed with 30 μl of 1 mM P-nitrophenyl-N-acetyl-β-d-glucosaminide in a 96-well plate and incubated for 1 hour at 37 ° C in a constant-temperature bath. And the absorbance was measured at a wavelength of 405 nm. The degree of inhibition of β-hexosaminidase was expressed based on the absorbance intensity, and the results were as shown in FIG.

As shown in FIG. 6, when the composition according to one embodiment of the present invention was treated, β-hexosaminidase inhibitory effect of RBL-2H3 cells was examined. hexosaminidase. However, since the compositions of Examples 2-7 to 2-9 are cytotoxic, the combination of Examples 2-6 is the most preferable composition because it is excellent in atopy improvement without toxicity.

Example 3: Preparation of a cosmetic composition for skin soothing and atopic dermatitis, which comprises Example 2 of the present invention

The composition shown in Table 3 below was prepared by mixing the basic formulation raw materials of the pack with a composition of 2: 1: 2: 0.3: 0.5 at a ratio of 2: 1: 2: 0.3: 0.5 to the extract of clover, Magnolia bark extract, To 10% by weight, and the remaining amount was filled with purified water until the weight became 100% by weight.

Experimental Example 5: Anti-inflammatory effect of Example 3

In order to evaluate the anti-inflammatory effect of the present invention, the compositions of the comparative examples and the examples were measured on applicants, and a human body application test was performed to measure the effect obtained by actual consumers.

In order to measure the sedative effect on other inflammations depending on the type of irritation applied to the skin, the present invention is applied to the suppression of actinic erythema caused by overexposure to ultraviolet rays, which is caused by overexposure to infrared rays and thermic erythema The effect of the composition was tested. The volunteers conducted a panel consisting of 10 women between the ages of 22 and 59 and 10 men between the ages of 10 and 29 years.

Inflammatory sedative effect by the injection effect was measured by measuring subcutaneous capillary blood circulation, skin erythema and skin temperature. Subcutaneous capillary blood circulation is specified by a thermoelectric measuring device (hematron). When capillary vessels shrink, the conductivity decreases and when they expand, they increase. Reduction of inflammation is an indicator that the swelling of swollen capillaries does not cause swelling. Skin erythema was measured using a Minolta CR300 chromometer and skin temperature was also measured using a hematron.

Infrared irradiation device used for inducing heat erythema was IR Phillips 250 S, and irradiated intensity was 70 mW / cm ² at a distance of 50 cm for 30 minutes to cause erythema. The irradiated area was 14 cm ² . Ultraviolet irradiation was conducted at 4 cm ² with a 100 W intensity using a UV irradiation apparatus (SUNTEST / ORIGINAL HANAU) equipped with a Xenon lamp. Minimal Erythemal Dose (MED) was determined for each volunteer. The inflammatory soothing effect of the composition of the present invention was measured 24 hours after irradiation with ultraviolet rays, and the results are shown in Tables 4 and 5 below.

In the above examples, it was confirmed that the effect was insignificant when the concentration of the composition was less than 0.1% by weight. However, when the composition contains 20% by weight of the composition, various problems such as separation of the cosmetic formulation and precipitation of the extract are produced, and the incorporation range of the composition is preferably 0.1 to 10% by weight have.

Claims (5)

20 parts by weight of a centilla extract, 10 parts by weight of an extract of Magnolia bark extract, 20 parts by weight of an extract of Hachiliaceae, 1 to 5 parts by weight of eucalyptus oil, and 1 to 5 parts by weight of oil of Borage seed oil. Composition. delete delete The method according to claim 1,
A cosmetic composition comprising at least one selected from the group consisting of softening lotion, astringent lotion, nutritional lotion, essence, nutritional cream, massage cream, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray and powder. The method according to claim 1,
And 0.5 to 10% by weight of the combined extracts based on the total weight of the composition.

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