KR100513659B1 - Cosmetic Composition for Improving Atopic Dermatitis Containing Extracts from Plants as Active Ingredient - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving atopic dermatitis containing a mixed extract of red ginseng, baekbaek, gimo and leaflet vegetation as an active ingredient, the cosmetic composition has antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effect , Through the synergistic effect of the effect to improve skin dryness and eczema that is characteristic of atopic skin, to treat and prevent secondary infection by microorganisms, and to relieve itching. In addition, the ingredient has no side effects as a herbal medicine.

Description

Cosmetic composition for improving atopic skin containing plant extracts {Cosmetic Composition for Improving Atopic Dermatitis Containing Extracts from Plants as Active Ingredient}

The invention Sophora (Sophora angustifolia SIEB. Et Zucc) , baekgeup atopic skin improving containing mixture extract as an active ingredient of (Bletilla striata REICHB. Fil.) , Jimo (Anemarrhena asphodeloides BUNGE.) And lobular maekmundong (Ophiopogon japonicus) It relates to a cosmetic composition for, more specifically, to improve atopic skin through excellent antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effect.

Atopy, atopia in Latin, is a word with an odd meaning (odd) that is prone to irritable reaction. Atopy causes a series of allergic symptoms in the skin and respiratory mucosa, eye mucosa and intestinal mucosa in individuals with atopic inducers. People with atopy-inducing factors often have urticaria reactions in skin tests for protein substances frequently encountered in the outside environment, such as house dust, mites, animal hair, food, pollen, and mold, and when eating or inhaling certain protein substances, Symptoms include itching, skin attacks, hives, angioedema, sneezing, runny nose, stuffy nose, conjunctival hyperemia and tearing. These atopy triggers are inherited and appear to be family. Allergic diseases caused by atopy-inducing factors include atopic dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, allergic enteritis, and atopic urticaria. These diseases are caused by genetic predisposition, environment, and age of each patient. It may appear alone or in combination. Among them, atopic dermatitis is a representative allergic skin disease in people with atopic allergy.

In the mechanism of allergic atopy, when allergens invade through the stratum corneum and reach the epidermal cells, macrophage (macrophage), a type of white blood cell, eats it and breaks it down. When macrophages cannot handle all of them because of the high amount of allergens invaded, they send information about the presence of untreated allergens to T cells, the same type of leukocytes, that control immunity and suppression. . T cells transmit the information back to eosinophils (eosinophilic leukocytes), a type of white blood cells, that bring eosinophils widely distributed in the blood to places where allergens invade. At this time, the eosinophils accumulated in the affected area cause inflammation due to excessive release of a chemical transfer material (active oxygen).

Usually, atopic dermatitis begins with infant eczema, commonly referred to as febrile fever, with itching in the acute phase, reddening, swelling, millet-like growth, small blisters, moist scabs, and itching in the chronic phase, The skin may become hard, thick, thin, or may have scales such as rice powder sitting or darkening or whitening.

Among the currently used therapeutic drugs, steroids (adrenal corticosteroids) have excellent effects on anti-inflammatory and immunosuppressive effects. However, one thing to watch out for is the side effects of steroids. Long-term application can cause hair to shine on the skin, shrink the skin, reduce skin pigments, cause bacterial infections, acne, thin skin, and uneven skin. In severe cases, hormonal systemic symptoms may occur and stop using the drug, and the symptoms may explode again. Also, systemic administration of the adrenal cortex is not recommended because the development of atopic dermatitis is common in infants before the age of five. Therefore, steroid ointments with very low hormone levels should be used only when necessary for a short period of time, and should be applied frequently instead of applying large amounts at once.

Antihistamines can be used as a temporary measure to relieve itching by preventing histamine from being released from mast cells, which can cause side effects such as insomnia, anxiety and loss of appetite.

Atopic dermatitis is more scary than secondary bacterial infections caused by itching and scratching. The skin of atopic patients is accompanied by bacterial infection as a result of prolonged scraping and drying. More than 90% of atopic patients are infected with Staphylococcus aureus, which is caused by scratching the patient's unbearable itching, and recent reports suggest that the toxins in these bacteria stimulate the body's immune system and cause allergies. It is said to make atopy worse. In other words, the bacteria themselves act as allergens. Therefore, the use of appropriate antibiotics is essential for the treatment of atopy.

In addition, there are nonsteroidal ointments for drug treatment. This is a type of moisturizer, which is applied at night to moisturize and then wrap it with a wrap. Moisturizing is an important part of the management of atopic dermatitis because dry skin, which is one of the symptoms of atopic dermatitis, tends to cause itching and eczema and is a factor of recurrence and exacerbation of atopic dermatitis.

In addition, sedatives or neurostabilizers may be used to calm the patient.

In view of the characteristics of these atopy, it is understood that the development of a substance having no side effects while providing antibacterial, moisturizing, anti-inflammatory, free radical scavenging and antioxidant effects as essential items of the atopy treatment.

On the other hand, Korean Patent No. 370455 discloses a composition for improving atopy comprising soy extract, trihydroxy palmitic acid and N-stearoyl-phytosphingosine, and Korean Patent No. 377262 improves atopy containing mugwort extract. The present invention discloses a cosmetic composition, and Korean Patent Application Publication No. 2003-32631 discloses a cosmetic composition for treating atopic dermatitis, including plant extracts such as jujube, vinegar liquor, aloe and the like.

Throughout this specification, reference is made to a number of patent documents, and the disclosures of the cited patent documents are incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained. .

The present inventors have searched a number of natural products to overcome the shortcomings of the raw materials having a healing effect of the conventional atopic skin and to find a substance having an excellent effect on improving atopic skin, the mixed extract of red ginseng, baekrye, jimo and leaflet vegetation It has excellent antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects. Through this action, atopic dermatitis is improved, and in particular, mixed extracts are used in combination at an appropriate ratio than using each single extract alone. By confirming that the case exhibits an increased effect, the present invention can effectively improve atopic skin without side effects.

Accordingly, an object of the present invention to provide a cosmetic composition for improving atopic skin.

Other objects and advantages of the present invention will become apparent from the following examples and claims.

According to one aspect of the invention, the invention is effective to mix the extract of Sophora flavescens (Sophora angustifolia SIEB. Et Zucc), baekgeup (Bletilla striata REICHB. Fil.) , Jimo (Anemarrhena asphodeloides BUNGE.) And lobular maekmundong (Ophiopogon japonicus) It provides a cosmetic composition for improving atopic skin containing as a component.

The composition of the present invention is characterized in that it contains as a active ingredient a mixed extract of red ginseng, baekbaek, gimo and lobular vegetation.

Ginseng is a perennial herb, reaching 100 cm in height. Ginseng refers to the root and is harvested in spring and autumn. Roots contain alkaloids d-matrin, d-oxymatrine, d-sophoranol, l-methyl cyticin, l-baptoline and l-sopocarpine, and flavonoids xanthohumol and isoxanthohumol And camphorol and the like. Main effects include diuretic and antibacterial effects.

White is a perennial herb, grows about 30-70 cm in height, and tubers are yellowish white with triangular ovate connected to thick flesh. Pangteum is a tuber that grows in roots in August-November to remove stems and beard roots, and then wash it clean. Ingredients include fresh 10.2% water, 30.48% starch, 1.5% glucose, essential oils, mucus, and bletilla mannan, which are found in 4 molecules of mannose. One molecule of glucomannan. Main effects include hemostasis, anti-inflammatory and moisturizing action.

Jimo is a perennial herb, with long and thin roots, extending horizontally, harvested in spring and autumn. Jimo refers to the rhizome, and the main ingredient is saponin, which contains about 6%. In addition to saponins, it contains reducing sugars, mucus, tannic acid and fatty oils. Main effects include antibacterial and antipyretic effects.

Lobules vegetation is a tuber of perennial herbaceous vein vegetation belonging to the family Liliaceae. The muscle muscle contains steroid saponins, whose aglycone is ruscogenin. It also contains β-sitosterol, stigmasterol and β-sitosterol-β-di-glucoside and the like.

The plant extract of the present invention can be obtained using various extraction methods known in the art, and preferably, (a) water, (b) anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol). , Butanol, etc.), (c) the mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butylene glycol, (h) hexane, (i) Propylene glycol etc. can be obtained as an extraction solvent.

On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can be obtained plant extracts having substantially the same effect using not only the aforementioned extraction solvent but also other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the plant extract of the present invention.

The plant extract of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Referring to one embodiment of the manufacturing method of the mixed extract of high ginseng, baekbaek, gimo and lobular vegetation of the present invention are as follows:

At least one solvent selected from the group consisting of water, ethanol, methanol, butanol, ethyl acetate, nucleic acid, butylene glycol , propylene glycol, and glycerin as an extraction solvent for the dry weight ratios of red ginseng, urine, pulp, and lobular vegetation 1-20 Pear volume is added. Extraction method is a method of extracting by heating for 2-20 hours at 50-95 ℃ or by extracting the active ingredient at 5-50 ℃ for 1-15 days while the cooling condenser is installed to prevent evaporation of the solvent Can be used.

According to a specific embodiment, preferably dried red ginseng, baekbaek, gimo and lobular vegetation (weight ratio 1: 2: 1: 1) are put into butylene glycol and extracted by heating in an extractor equipped with a cooling condenser. Then, filtered with a filter cloth, cooled, left for a period of time, and finally filtered with a filter.

In a preferred embodiment of the present invention, the content of the mixed extracts of red ginseng, baekpan, gimo and lobular vegetation is 0.01-20.0% by weight, preferably 0.01-10.0% by weight, most preferably 0.10-3.0% by weight, based on the total weight of the composition. %to be.

The components included in the cosmetic composition of the present invention include components commonly used in cosmetic compositions in addition to the mixed extracts of red ginseng, baekryeum, gi, and leaflet veins as active ingredients, and include, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments. And conventional adjuvants such as perfumes, and carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The mixed extract of ginseng, baekbaek, gimo and lobular vegetation of the present invention has excellent antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effect, so it can solve safety problems at the same time. In particular, when used in combination at an appropriate ratio than using each component alone, it was confirmed that the excellent antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effect.

The mixed extract of the present invention improves skin dryness and eczema characteristic of atopic skin through synergistic effects of the antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects, and treats and prevents secondary infection by microorganisms. To relieve itching.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Example: Preparation method of complex extract of red ginseng, baekryum, gimo, lobular vegetation

Example 1.

200 g of dried ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation were added to 5 kg of distilled water and extracted by heating at 100 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days and finally filtered through a 0.3 μm filter to obtain 4 kg of a liquid extract.

Example 2.

200 g of dried ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation were placed in 5 kg of 30% alcohol and extracted by heating at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooling to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 70 g of a powder extract was obtained.

Example 3.

200 g of dried red ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation are placed in 5 kg of 95% alcohol and extracted by heating at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooling to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 45 g of a powder extract was obtained.

Example 4.

200 g of dried red ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation were placed in 5 kg of 30% butylene glycol and extracted by heating at 85 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooled to room temperature, it was left for 5 days at 5-15 ℃, and finally filtered with a 0.3 ㎛ filter to obtain a liquid extract 4 kg.

Example 5.

200 g of dried red ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation were placed in 5 kg of 30% propylene glycol and heated and extracted at 85 ° C. for 3 hours in an extractor equipped with a cooling condenser. Filtration with a 400 mesh filter cloth, cooled to room temperature and left for 5 days at 5-15 ℃, and filtered with a final 0.3 ㎛ filter to obtain a liquid extract 4 kg.

Example 6.

200 g of dried red ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaf leaf veins were placed in 5 kg of 30% glycerin and boiled for 3 hours in an extractor equipped with a cooling condenser, filtered through a 400 mesh filter cloth and cooled to room temperature. The mixture was left to stand at 15 ° C. for 7 days, aged, filtered through filter No. 5, and finally filtered through a 0.3 μm filter to obtain 4 kg of a liquid extract.

Example 7.

200 g of dried ginseng, 400 g of white ginseng, 200 g of Jimo and 200 g of leaflet vegetation were placed in 5 kg of 30% methanol and extracted by heating at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 40 g of a powder extract was obtained.

Example 8.

200 g of dried red ginseng, 400 g of white ginseng, 200 g of gummy and 200 g of leaf leaf veins were placed in 5 kg of 30% ethyl acetate and extracted by heating at 70 ° C. for 3 hours in an extractor equipped with a cooling condenser. After filtration through a 400 mesh filter cloth and cooled to room temperature, the mixture was left at 5-15 ° C. for 7 days, finally filtered through a 0.3 μm filter, concentrated under reduced pressure, and 42 g of a powder extract was obtained.

Experimental Example 1: Antibacterial and antifungal effect experiment

The antibacterial and antifungal effects were measured by using the extract of Gosam, Geum extract, and the extract of Gosam, Baek, Jimo, and Bovine Leafy Worm of Example 4.

Experiment method

Antimicrobial and antifungal experiments were measured by agar diffusion using a paper disc. The strain was inoculated with 100 ml of liquid medium and activated by incubating for 48 hours at 37 ° C (Table 1). 100 μl of the strain culture was inoculated (107-108 cfu / ml) on top agar (0.75% agar) plate and applied onto the plate. Plant extracts were injected into sterile paper discs 20 [mu] l and dried, then the discs were placed on the plate surface. 36 hours of incubation and antimicrobial and antifungal activity was measured by the clear zone (clear zone) generated around the agar plate.

Strain was used as the following microorganisms disclosed strains of: Candida albicans (Candida albicans, ATCC 10259), E. coli (Escherichia coli, ATCC 25922), Streptococcus Au Claire's (Staphylococcus aureus, ATCC 29737), B. subtilis ( Bacillus subtilis, ATCC 6633). Growth medium of the strain was usually used agar (nutrient agar) or trypticase soy agar (trypticase soy agar; Difco) and the culture conditions for each strain are shown in Table 1 below. The experimental results are shown in Table 2 below.

Culture conditions for each strain number Strain badge type One Candida Albican Common agar Exhalation 2 Escherichia coli Tryticase Bean Agar Exhalation 3 Streptococcus aureus Common agar Exhalation 4 Bacillus subtilis Common agar Exhalation

Antibacterial and Antifungal Effects of the Extracts of Ginseng Extracts, Hair Extracts, and Mixed Extracts of Red Ginseng, Paek, Gimo, and Leaflet Macaques (Unit: ㎜; Diameter of transparent range) Strain Escherichia coli Streptococcus aureus Bacillus subtilis Candida Albican Extract concentration (% by weight) Four kinds of mixture Gosam Jimo Four kinds of mixture Gosam Jimo Four kinds of mixture Gosam Jimo Four kinds of mixture Gosam Jimo One 8 5 4 8 5 6 8 5 7 9 6 5 3 9 6 7 10 6 7 9 7 8 10 7 7 5 10 7 7 10 7 7 10 8 8 10 8 8 7 12 8 9 11 8 9 11 8 9 12 8 9 9 14 9 9 13 9 9 14 9 9 14 9 9

Table 2 shows that the mixed extract of red ginseng, baekryeok, gimo and leaflet vegetation has excellent antibacterial and antifungal effects, and concentration-dependently antibacterial and antifungal action.

Ginseng extract and hair extract have been used for the treatment of skin eczema and neurodermatitis because of its antibacterial and antifungal action. In particular, ingredients such as flavonoids of the ginseng and matrin, and mangiferin of hair are known to be effective in skin flora. However, as can be seen in Table 1, the effect was increased when four kinds of mixed extracts than the effect of using each as a single component.

Experimental Example 2: Free radical scavenging effect experiment

Free radical scavenging effect was measured by using the extract of the ginseng extract, and the extracts of the ginseng, baekrye, gimo and lobular vegetation of Example 4.

Experiment method

2 ml of a 0.2 mM 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution was reacted with red ginseng extract or a mixture of red ginseng, turmeric, hairy and leaflet vegetation at room temperature for 10 minutes at each temperature, followed by 520 nm. Absorbance was measured at to determine the free radical scavenging effect (%). At this time, a control experiment was performed simultaneously, and the results are shown in Tables 3 and 4 below.

Free Radical Scavenging Effect on the Extract of Red Ginseng Final concentration of ginseng extract (% by weight) Free radical scavenging effect (%) IC ₅₀ 0.53 10 3.0% 1.57 32 2.59 47 3.01 50 4.51 82

Free Radical Scavenging Effects on Mixed Extracts of Korean Red Ginseng, P. vulgaris, and Gemini Final concentration (wt%) of mixed extracts of red ginseng, baekbaek, gimo, and leaflet veins Free radical scavenging effect (%) IC ₅₀ 0.67 21 1.6% 1.33 43 2.00 62 3.33 85 4.67 92

As a result of measuring the free radical scavenging effect of the mixed extracts of red ginseng, baekpan, gimo and lobular vegetation, it was found that the effect increased in a concentration-dependent manner. Moreover, a single extract of ginseng known to have an antiallergic effect It can be seen that the effect is much better than the free radical scavenging effect (Table 3).

Experimental Example 3: Anti-inflammatory Effect Experiment

The anti-inflammatory effect was measured using a single extract of each of the four species and the mixed extract of red ginseng, baekrye, gimo and lobular vegetation of Example 4.

Experiment method

The left ear of the mouse was used as the control site and the right ear was the test site, and the ears were washed with ethanol before each extract sample was applied. 20 μl of the extract sample was continuously applied to both ears once a day for 4 days, and 1 mg after the last application, ethanol was applied to the left ear and arachidonic acid (arachidonic acid) was applied to the right ear 2 mg / ear. After 1 hour, the ear edema was measured by repeating the measurement of both ears three times with a micrometer.

The anti-inflammatory effect was determined as the degree of edema inhibition based on the arachidonic acid treatment group, and indomethacin was used as a positive control. The results are shown in Table 5 below.

% Inhibition = (A-B) / A × 100

In Equation 1, A is the difference in the average thickness of the control ear (arachidonic acid-treated ear thickness-ethanol-treated ear thickness), B is the difference in the thickness of the ginseng, baekbaek, gimo and lobular pulmonary pulmonary mixed extract or single extract applied group ears (arakidon Thickness of acid treated ears-ethanol treated ear thickness).

Anti-inflammatory Effects of Single Extracts and Four Mixed Extracts sample Final concentration in the reaction solution (% by weight) Solvent Ear thickness (㎛) % Inhibition Ethanol treatment Arachidonic acid treatment Untreated group (control group) - ethanol 299 551 - Indomethacin 1.0 ethanol 320 465 42.5 Hair extract 1.0 ethanol 241 446 18.7 Ginseng extract 1.0 ethanol 285 489 19.0 Bovine leaf vegetation extract 1.0 ethanol 296 510 15.1 Platinum extract 1.0 ethanol 259 467 17.5 4 kinds of mixed extract 1.0 ethanol 285 471 26.2

As can be seen in Table 5, when using four kinds of mixed extracts than when using a single extract showed an excellent anti-inflammatory effect.

Experimental Example 4: Moisturizing Effect Experiment

Moisturizing effect was measured using a single extract of each of the four species and the mixed extract of red ginseng, baekrye, gimo and lobular vegetation of Example 4.

Experiment method

Twenty women in their twenties were divided into 12 sections in the range of 2 × 2 ㎠ and washed several times with water to remove moisture without irritation. After 5 minutes, 10 μl of purified water, 1.0% Gosam extract, 1.0% white extract, 1.0% hair extract, 1.0% lobular vegetation extract, and 1.0% red ginseng, baekryum, gimo, lobular vegetation mixed extracts were added for 2 compartments. And evenly applied. After 10 minutes, five measurements were taken per compartment using Corneometer CM 825 (Courage + Khazaka) and seven measurements were taken at five minute intervals. The room temperature was 20 ° C and the relative humidity was 20%. The results are shown in Table 6 below, with each value being the average for 20 people.

Moisture content (%) = Corneometer reading after sample application-Corneometer reading before sample application

Determination of Moisturizing Effect of Extracts Minutes Purified water 1.0 wt% Gosam extract 1.0 wt% White Extract 1.0 wt% hair extract 1.0 wt% leaflet vein copper extract 1.0% by weight Gosam, White, Gemini, Leaflet vein sinus mixed extract 10 10.6 27.5 29.6 24.4 31.3 37.4 15 8.1 24.9 25.3 20.1 28.2 35.1 20 6.5 21.0 19.4 17.4 20.5 25.3 25 2.1 16.2 17.4 13.8 18.2 21.1 30 0.5 12.1 14.2 11.9 13.2 15.6 35 0.0 11.4 12.9 8.5 10.5 13.0 40 0.0 9.2 10.0 6.1 8.1 12.8

When four kinds of mixed extracts were used, the moisturizing power was improved and the sustainability was superior to the moisturizing effect of each extract only.

Formulation Example 1

Examples of the formulation of the lotion (skin lotion) in the cosmetics containing a mixture of red ginseng, baekbaek, gimo, lobular vegetation mixed extract (Example 4) are shown in Table 7.

Number Raw material Formulation Example 1 (% by weight) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 5.0 2 glycerin 3.0 3 Butylene Glycol 2.0 4 Propylene glycol 2.0 5 Polyoxyethylene (60) Cured Castor Oil 1.0 6 ethanol 10.0 7 Triethanolamine 0.1 8 antiseptic a very small amount 9 Pigment a very small amount 10 Spices a very small amount 11 Purified water Remaining amount

Formulation Example 2

 Formulation examples of nutritional lotion in cosmetics containing a mixture of Gosam, Baekji, gimo, and leaflet vegetation extract (Example 4) are shown in Table 8.

Number Raw material Formulation Example 2 (wt%) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 10.0 2 Beeswax 1.0 3 Polysorbate 60 1.5 4 Sorbitan sesquioleate 0.5 5 Liquid paraffin 10.0 6 Sorbitan stearate 1.0 7 Lipophilic Monostearic Acid Glycerin 0.5 8 Stearic acid 1.5 9 Glyceryl Stearate / Pig-400 Stearate 1.0 10 Propylene glycol 3.0 11 Carboxy Vinyl Polymer 0.1 12 Triethanolamine 0.2 13 antiseptic a very small amount 14 Pigment a very small amount 15 Spices a very small amount 16 Purified water Remaining amount

Formulation Example 3

Examples of the formulation of nutrition cream in cosmetics containing a mixed extract of Gosam, Baekji, gimo, and leaflet vegetation (Example 4) are shown in Table 9.

Number Raw material Formulation Example 3 (wt%) Comparative formulation example (% by weight) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 10.0 - 2 Beeswax 8.0 8.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.5 0.5 5 Liquid paraffin 20.0 20.0 6 Sorbitan stearate 1.0 1.0 7 Lipophilic Monostearate Glycerin 0.5 0.5 8 Stearic acid 1.5 1.5 9 Glyceryl Stearate / Pig-400 Stearate 1.0 1.0 10 Propylene glycol 6.0 6.0 11 Triethanolamine 0.2 0.2 12 antiseptic a very small amount a very small amount 13 Pigment a very small amount a very small amount 14 Spices a very small amount a very small amount 15 Purified water Remaining amount Remaining amount

Formulation Example 4

Formulation examples of the massage cream in cosmetics containing a mixture of Gosam, Baekgi, Gimo, and leaflet vegetation extract (Example 4) are shown in Table 10.

Number Raw material Formulation Example 4 (wt%) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 10.0 2 Beeswax 10.0 3 Polysorbate 60 1.5 4 Sorbitan sesquioleate 0.8 5 Liquid paraffin 40.0 6 Squalane 5.0 7 Lipophilic Monostearic Acid Glycerin 1.0 8 Carboxy Vinyl Polymer 0.2 9 Butylene glycol 6.0 10 glycerin 6.0 11 Triethanolamine 0.2 12 antiseptic a very small amount 13 Pigment a very small amount 14 Spices a very small amount 15 Purified water Remaining amount

Formulation Example 5

Red ginseng, white weight, hairy, leaflet vegetation mixed extract The formulation example of the nutritional essence among the cosmetics containing (Example 4) is shown in Table 11.

Number Raw material Formulation Example 5 (wt%) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 5.0 2 Cytostolol 13.0 3 Polyglyceryl 2-oleate 0.2 4 Ceramide 0.1 5 Ceteares-4 5.0 6 cholesterol 0.3 7 Dicetylphosphate a very small amount 8 Concentrated glycerin 1.0 9 Macadamia oil 0.2 10 Carboxy Vinyl Polymer a very small amount 11 Xanthan Gum a very small amount 12 antiseptic a very small amount 13 Spices a very small amount 14 Purified water Remaining amount

Formulation Example 6

Formulation examples of emulsified foundations in cosmetics containing a mixture of red ginseng, baekbaek, gimo, and leaflet vegetation extract (Example 4) are shown in Table 12.

Number Raw material Formulation Example 6 (wt%) One Red ginseng, white weight, hairy, leaflet vegetation mixed extract 10.0 2 Beeswax 2.0 3 Pyromethicone 2.0 4 Liquid paraffin 5.0 5 Squalane 5.0 6 Stearic acid 2.0 7 Lipophilic monostearic acid glycerin 3.0 8 Macadamia oil 4.0 9 glycerin 4.0 10 Propylene glycol 3.0 11 Butylene glycol 3.0 12 Triethanolamine 1.0 13 Aluminum Magnesium Silicate 0.5 14 Pigment 12.0 15 antiseptic a very small amount 16 Spices a very small amount 17 Purified water Remaining amount

Experimental Example 1: Confirmation test to improve atopic healing

When applying the skin of the nutrition cream of Formulation Example 3 and Comparative Formulation Example, the following clinical experiments were conducted to confirm the effect of atopic skin improvement. Atopic dermatitis improvement effect was investigated in 20 patients with atopic dermatitis aged 5-30 years who had atopic dermatitis for more than 2 years. To the same person, the nourishing cream of Formulation Example 3 on the left hand and the nourishing cream of the Comparative Formulation Example on the right hand were washed every evening, and then applied to the skin once a day for 60 days and the degree of atopic dermatitis improvement was measured. The results are shown in Table 13 below.

Atopic Dermal Healing Effect of Korean Red Ginseng, Baekji, Gimo, and Leaflet Veins sample Survey Item Improve Atopy Condition Number of people % Formulation Example 3 very good 16 80.0 good 4 20.0 is average - - so so - - Comparative Formulation Example very good - - good 2 10.0 is average 5 25.0 so so 13 65.0

As shown in Table 13, it can be seen that the cosmetic composition of Formulation Example 3 prepared by adding a mixed extract of red ginseng, baekryum, gimo, and leaflet vegetation has an atopic skin improvement effect than the cosmetic formulation of the comparative formulation without the extract. In particular, when using the cosmetic formulation of Formulation Example 3 containing the mixed extract of the present invention showed an excellent effect to improve the skin keratinization and inflammation and to relieve itching.

As described above, the present invention provides a cosmetic composition containing a mixed extract of red ginseng, baekbaek, gimo and lobular vegetation. The cosmetic composition of the present invention has antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects, and effectively improves atopic skin through synergistic effects of the above effects, and the ingredient has no side effects as a herbal medicine.

Claims (4)

A cosmetic composition for improving atopic dermatitis comprising a mixed extract of red ginseng, baekryum, gimo and lobular vegetation as an active ingredient. The cosmetic composition for improving atopic skin of claim 1, wherein the composition improves atopic skin through antibacterial, antifungal, free radical scavenging, anti-inflammatory and moisturizing effects. The cosmetic composition for improving atopic dermatitis according to claim 1, wherein the content of the mixed extract of red ginseng, baekryum, gimo and leaflet veins is 0.01-20.0% by weight based on the total weight of the composition. The composition of claim 1, wherein the composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation Cosmetic composition for improving atopic skin, characterized in that having a formulation selected from the group consisting of, wax foundation and spray.