KR102142931B1 - Composition for reducing sebum secretion comprising Rhus Semialata M. Fruit Extracts - Google Patents

Abstract

The present invention relates to a composition for suppressing sebum secretion containing the Rhus Semialata M. fruit extract as an active ingredient, and the composition of the present invention comprising the Rhus Semialata M. fruit extract suppresses sebum hypersecretion by inhibiting the differentiation of sebaceous cells. It has the effect of preventing, improving, or treating pore expansion or seborrheic dermatosis caused by sebum. In addition, the composition has no skin irritation and cytotoxicity, has excellent human stability, and is very effective in suppressing sebum secretion, so it can be safely used as an active ingredient in cosmetics or pharmaceutical compositions for the prevention, improvement or treatment of pore expansion or seborrheic dermatosis. have.

Description

Composition for reducing sebum secretion comprising Rhus Semialata M. Fruit Extracts}

The present invention relates to a composition for inhibiting sebum secretion comprising a Rhus Semialata M. fruit extract as an active ingredient, and more specifically, to inhibit sebum differentiation to prevent pore expansion or seborrheic dermatosis caused by sebum hypersecretion, It relates to a cosmetic or pharmaceutical composition comprising a red tree fruit extract that can be improved or treated as an active ingredient.

Sebum plays a role of protecting the skin by forming a thin sebum film on the skin surface, preventing external invasion and inhibiting evaporation of moisture from the skin. Sebum is produced from sebocytes present in the skin. The main mechanism of sebum production known to date is through the IGF-1/PI3K/Akt pathway upon stimulation of insulin or IGF-1 (Insulin-like growth factor-1). It has been reported that the lipogenesis process is induced by increasing the expression of SREBPs. The regulation of sebum production is that when AMPK is activated through the AMPK-SREBP-1 signaling pathway in sebaceous cells, signals are sequentially activated through the IGF-1/PI3K/Akt pathway, thereby inhibiting the expression of SREBPs, thereby reducing lipogenesis (Smith TM, Cong Z, Gilliland KL et al. Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1, J Invest Dermatol, 2006, 126: 1226-1232). As factors that promote sebum production, ultraviolet rays, cortisol, and male hormones are known.

When sebum secretion increases, facial glossiness and pores increase, making the skin look rough and thick, making the skin look stuffy, and the skin color becomes dull and dark. When sebum reacts with external stimuli such as air and ultraviolet rays, black heads are generated through oxidation reactions, making pores more prominent. Seborrhea is a disease seen in various age groups, and it is known to be caused by excessive secretion of sebum as well as skin microorganisms (Evidence Based Dermatology 2nd edition 2008;164-170). Until now, studies on improving seborrheic skin symptoms have mostly been conducted in a way that suppresses fungi present in the skin. In fact, when using isotretinoin, a vitamin A derivative drug that affects sebaceous secretion cells, inhibition of sebum secretion cell proliferation and reduction of sebum secretion were confirmed both in vitro and in vivo , and clinical symptoms due to excessive sebum secretion were also improved. (Int J Dermatol. 2017 Jan;56(1):80-85; Dermatology. 1998;196(1):21-31.).

On the other hand, Rhus Semialata M. is a deciduous small arboreous tree belonging to the sumacaceae family. It is mainly distributed in Northeast Asia such as Korea, China, and Japan, and is called a red tree because of its exceptional red leaves in autumn. In addition, redwood fruit matures in October and has a sour and salty taste, and is used as a bittern for making tofu, so it is also called a salted tree. do. Regarding the efficacy of redwood, Korean Patent Registration No. 10-1617152, a cosmetic composition containing the redwood unripe fruit extract as an active ingredient, Korean Patent Registration No. 10-0997641, a cosmetic composition containing a molecularly encapsulated redwood extract fermented product, as an active ingredient, Korea Registered Patent No. 10-0872454 There is a method for extracting functional cosmetic ingredients from plants, and the information on the activity of the dammarein triterpene compounds isolated from redwood is disclosed in Korean Patent No. 10-0873222 atherosclerosis and cancer containing the dammarein triterpene compound. And a composition for preventing, improving and treating oxidative stress, Korean Patent No. 10-0685516, a novel anticancer active triterpene-based compound, and a method for preparing the same. However, up to now, including the above patent literature, there has not been reported any composition having the effect of preventing seborrheic skin and pore expansion through the sebum secretion inhibitory effect of the red tree fruit extract.

Accordingly, the present inventors search for candidate substances that alleviate pore enlargement and seborrheic skin symptoms through a mechanism of suppressing sebum production in natural products, and develop natural materials that can prevent pore expansion and seborrheic dermatosis caused by excessive sebum secretion. During the study, it was confirmed that the red tree fruit extract inhibits the differentiation of sebaceous cells, suppresses sebum production, and reduces sebum secretion in actual clinical practice, thereby having the effect of preventing pore expansion and seborrheic dermatosis caused by sebum oversecretion. The present invention has been completed.

The technical problem to be solved in the present invention is to provide a composition for suppressing sebum secretion, including the Rhus Semialata M. fruit extract as an active ingredient.

Another technical problem to be solved in the present invention is to provide a cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis comprising a red tree fruit extract as an active ingredient.

Another technical problem to be solved in the present invention is to provide a pharmaceutical composition for the prevention or treatment of pore expansion or seborrheic dermatosis comprising a red tree fruit extract as an active ingredient.

In order to solve the above technical problem, the present invention is to provide a composition for suppressing sebum secretion comprising a red tree fruit extract as an active ingredient.

In order to solve the above-described other technical problem, the present invention is to provide a cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis comprising the composition for suppressing sebum secretion.

In order to solve the above-described other technical problem, the present invention is to provide a pharmaceutical composition for preventing or treating pore expansion or seborrheic dermatosis comprising the composition for suppressing sebum secretion.

The term "extract" of the present invention refers to a preparation obtained by squeezing a herbal medicine into an appropriate leachate and evaporating the leachate, but is not limited thereto, but is not limited to the extract obtained by the extraction treatment, the dilution or concentrate of the extract, or the extract. It may be a dried product obtained by drying, a preparation or purified product thereof.

In the present invention, the red tree fruit extract may be extracted using a conventional solvent known in the art, and the extracted liquid may be used in a liquid form or concentrated and/or dried. At this time, as the solvent, water, an anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), a mixed solvent of the lower alcohol and water, acetone, ethyl acetate, chloroform, or 1,3- Any one of butylene glycol may be used. Preferably, it can be extracted using methanol, ethanol or butanol. However, it is not particularly limited thereto, and since the degree of extraction and loss of the active ingredient of the extract may vary depending on the organic solvent to be extracted, it is preferable to select and use an appropriate organic solvent.

The extraction method is not particularly limited thereto, but includes cold needle extraction, ultrasonic extraction, or reflux cooling extraction method, and it is preferable to perform ultrasonic extraction.

In addition, the red tree fruit extract can be obtained through a conventional purification process in addition to the method of extracting with the extraction solvent. For example, through various additional purification methods, such as separation using an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity, or affinity). It is also possible to obtain a red tree fruit extract through the obtained fraction.

According to one specific embodiment of the present invention, 0.5 to 20 times, preferably 1 to 15 times the weight of the dried sample after grinding redwood fruit in the shade of C1 to C4 such as water, ethanol, methanol, etc. Using a lower alcohol or a mixed solvent of water and ethanol at high temperature for about 20 to 70 hours, preferably 40 to 50 hours, using an extraction method such as stirring extraction, hot water extraction, cold needle extraction, reflux cooling extraction, or ultrasonic extraction. , Preferably, the extract obtained after hot water extraction may be filtered, concentrated under reduced pressure, or dried to obtain a red tree fruit extract.

In the present invention, the red tree fruit extract includes all extracts, fractions and purified products obtained in each step of extraction, fractionation or purification, and all of their dilutions, concentrates or dried products.

The composition for inhibiting sebum secretion comprising the red tree fruit extract of the present invention as an active ingredient comprises 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight of the red tree fruit extract, based on the total weight of the composition. When the content of the red tree fruit extract is less than 0.0001% by weight, the sebum secretion inhibiting effect cannot be expected, and when it exceeds 20.0% by weight, the increase in the sebum secretion inhibiting effect due to the increase in the content is insignificant, and difficulty in manufacturing a pharmaceutical formulation occurs. .

In one specific embodiment, a cosmetic composition or pharmaceutical composition for the prevention, improvement or treatment of pore expansion or seborrheic dermatosis caused by sebum hypersecretion by inhibiting the differentiation of sebaceous cells containing the redwood fruit extract of the present invention as an active ingredient It can be used as a composition.

The cosmetic composition comprising the red tree fruit extract of the present invention as an active ingredient contains 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight of the red tree fruit extract, based on the total weight of the cosmetic composition. When the content of the red tree fruit extract is less than 0.0001% by weight, it is not possible to expect an effect in preventing or improving pore expansion or seborrheic dermatosis, and when it exceeds 20.0% by weight, it is difficult to prepare a cosmetic formulation.

The cosmetic composition may additionally include ingredients commonly used in cosmetic compositions in addition to the redwood fruit extract. For example, it may contain conventional auxiliaries and carriers such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors.

The cosmetic composition may be prepared in any formulation conventionally prepared in the art. For example, it may be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray. More specifically, it may be prepared in a formulation such as a nourishing cream, an astringent lotion, a flexible lotion, a lotion, an essence, a nourishing gel or a massage cream. However, it is not particularly limited thereto.

When the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as carrier components Can be used.

When the formulation of the cosmetic composition is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, Propellants such as propane/butane or dimethyl ether.

When the formulation of the cosmetic composition is a solution or emulsion, a solvent, a solubilizing agent, or an emulsifying agent may be used as a carrier component. For example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan can be used. have.

When the formulation of the cosmetic composition is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the cosmetic composition is a surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acids as carrier components Amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

More specifically, the present invention provides a pharmaceutical composition effective in preventing or treating pore expansion or seborrheic dermatosis by inhibiting the differentiation of sebaceous cells by including the redwood fruit extract as an active ingredient.

The pharmaceutical composition comprising the red tree fruit extract of the present invention as an active ingredient contains 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight of the red tree fruit extract, based on the total weight of the cosmetic composition. If the content of the red tree fruit extract is less than 0.0001% by weight, the effect of preventing or treating pore expansion or seborrheic dermatosis cannot be expected, and if it exceeds 20.0% by weight, the increase in the effect due to the increase in the content is insignificant, and a pharmaceutical formulation is prepared. Difficulty arises.

The pharmaceutical composition may further include a carrier generally acceptable for pharmaceutical compositions in addition to the redwood fruit extract.

Carriers that are generally acceptable for the pharmaceutical composition are those commonly used in formulation, and carbohydrate compounds (e.g., lactose, amylose, dextrose, sucrose, sorbitol, mannitol, starch, cellulose, etc.), gum acacia, phosphoric acid Calcium, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, salt solution, alcohol, gum arabic, vegetable oil (e.g. corn oil, cotton seed oil, soy milk, olive oil, Coconut oil), polyethylene glycol, methyl cellulose, methylhydroxy benzoate, propylhydroxy benzoate, talc, magnesium stearate, mineral oil and the like, but are not limited thereto.

The pharmaceutical composition of the present invention may further include a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, and the like in addition to the above components. Suitable pharmaceutically acceptable carriers and formulations are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995).

The pharmaceutical composition of the present invention can be applied to mammals such as rats, mice, livestock, humans, etc. by oral or parenteral administration, preferably parenteral administration, more preferably topical application by application. It can be applied in a way.

A suitable dosage of the pharmaceutical composition may be prescribed in various ways depending on factors such as formulation method, mode of administration, age, weight, sex, pathological condition, food, administration time, route of administration, excretion rate and response sensitivity of the patient. have. The oral dosage of the pharmaceutical composition of the present invention is in the range of 0.001-300 mg/kg (body weight) on an adult basis. In addition, in the case of an external preparation, it is good to apply for 1 to 5 times a day in an amount of 1.0 to 3.0 ml on an adult basis and continue for at least 1 month. However, the dosage is not intended to limit the scope of the present invention.

The cosmetic or pharmaceutical composition containing the redwood fruit extract of the present invention as an active ingredient inhibits the differentiation of sebaceous cells of an individual by intra-individual administration, subcutaneous administration or topical administration by application, and prevents excessive secretion of sebum, thereby expanding pores or There is an advantage that can achieve the purpose of relieving, ameliorating, preventing, improving or treating seborrheic dermatosis.

In one specific embodiment, the present invention is a method for improving pore dilatation or seborrheic dermatosis by administering a composition comprising a red tree fruit extract as an active ingredient to an individual to inhibit the differentiation of sebaceous cells of the individual and prevent excessive secretion of sebum, and It provides its use.

The composition administered to a subject of the present invention has the effect of improving or treating pore expansion or seborrheic dermatosis by inhibiting the differentiation of sebaceous cells and preventing excessive secretion of sebum as described above.

In the present invention, the term "subject" refers to monkeys, cows, horses, pigs, sheep, dogs, cats, rats, mice, including humans with conditions or diseases in which symptoms can be improved by administering the composition of the present invention, It means mammals such as chimpanzees.

In the present invention, the term "improvement" refers to (a) inhibition, (b) alleviation, (c) elimination of pore expansion or seborrheic dermatosis caused by hyperdifferentiation of sebum in an individual.

On the other hand, the redwood fruit extract of the present invention is a natural extract that does not have skin irritation and cytotoxicity, and has almost no side effects to the human body due to excellent human stability. It inhibits the differentiation of sebaceous cells and prevents excessive secretion of sebum, thereby expanding pores or seborrhea It can be safely used as an active ingredient in cosmetics or pharmaceutical compositions for the prevention, improvement or treatment of

According to the present invention, the composition of the present invention comprising a red tree fruit extract has an effect of preventing, improving or treating sebum-induced pore expansion or seborrheic dermatosis by inhibiting sebum hypersecretion by inhibiting the differentiation of sebaceous cells. In addition, the composition has no skin irritation and cytotoxicity, has excellent human stability, and is very effective in suppressing sebum secretion, so it can be safely used as an active ingredient in cosmetics or pharmaceutical compositions for preventing, improving or treating pore expansion or seborrheic dermatosis. have.

1 shows the degree of sebum secretion suppression after treatment with red tree fruit extract.

Hereinafter, examples, etc. will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be interpreted as being limited to the following examples. The embodiments of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

Example 1: Preparation of red tree fruit extract

After washing, drying, pulverizing and pulverizing 1 kg of redwood fruit, 1 L of purified water was added to 20 g of the powder, followed by hot water extraction in a sterilizer. The supernatant was concentrated using a concentrator, and then lyophilized to powder. The powdered extract was dissolved in sterilized distilled water at a concentration of 100 mg/mL, and then subjected to an aqueous injection filter having a pore size of 0.2 μm and used in the experiment.

Example 2: Preparation of an external preparation for skin containing redwood fruit extract

In order to measure the skin sebum secretion inhibitory effect of the redwood fruit extract, a skin external preparation containing redwood fruit extract was prepared with the components and contents of Table 1 below, and then skin safety and sebum secretion inhibition efficacy tests were performed. First, purified water, glycerin, and butylene glycol were mixed and dissolved at 70°C (water part), and the three components and the remaining ingredients were dissolved at 70°C (oil part). The oil part was added to the water part and emulsified by stirring with a homomixer (Tokushu Kika, Japan), and air bubbles were removed and then cooled to room temperature to prepare a skin external preparation.

ingredient content (%) Red fruit
External preparation for skin Purified water 72.05 Butylene glycol 4.0 glycerin 8.0 Red tree fruit extract 0.05 Caprylic Capri Triglyceride 8.0 Squalane 5.0 Cetearyl glucoside 1.5 Sorbitan Stearate 0.4 Cetearyl alcohol 1.0 Gross weight 100

Example 3: sebum secretion inhibitory efficacy test

In order to measure the sebum secretion inhibitory effect of the extract prepared in Example 1, the degree of inhibition of sebum production was measured through the degree of inhibition of the formation of lipid droplets of sebaceous cells (human sebocyte, Cellprogen, USA). Specifically, sebaceous cells were seeded on a collagen-coated 24 well-plate at 2 x 10 ³ cells/well and cultured, and then, after pre-treatment with redwood fruit extract, 20 nM of insulin to induce the differentiation of sebaceous cells was treated. After incubation for 8 days after treatment, the fat was stained with nile red, which stains the cell fat in red, and the amount of lipid produced was measured through a fluorescence microscope. As a result, it could be confirmed that fat-stained cells were significantly increased in the insulin 20 nM-treated group compared to the negative control group that was not treated with anything, and that the fat differentiation was normal. Under the conditions treated with the red tree fruit extract, it was observed that the results effectively inhibited the differentiation of fat. The results are shown in FIG. 1.

1 shows the degree of sebum secretion suppression after treatment with red tree fruit extract.

Example 4: Measurement of activity of reducing oil content by extract composition of red tree fruit

In order to confirm the change in oil content by the red tree fruit extract, the value of the red tree fruit extract skin external preparation prepared in Example 2 was measured before use, 2 weeks after use, and 4 weeks after use. The oil content was measured using Sebumeter SM810 (Courage-Khazaka eletronic GmbH, Germany) to measure the glabellar, which is the T zone. The measurement was performed once every time, and it was measured for 20 seconds and used as data for evaluating the skin oil content. Sebumeter is a device that measures the amount of sebum obtained after contacting the skin with a special semi-transparent lipid-absorbing tape (about 20 seconds) using the photometric reflection as the amount of oil per unit area (㎍ sebum/cm ² ). The measured value and the amount of oil are proportional.

(Mean±SD) division ㎍/㎠ Before use 142.39 ± 57.80 2 weeks after use 106.23 ± 51.38 4 weeks after use 72.54 ± 29.91

As shown in Table 2, the measured value of the oil content of the rice was 142.39 before use, 106.23 after 2 weeks of use, and 72.54 after 4 weeks of use. As a result of post-test according to the normality test, the measured value of oil content decreased significantly after 4 weeks of use compared to before use.

In order to check the sebum change caused by the use of redwood fruit skin external preparation, ea values were measured before use, 2 weeks after use, and 4 weeks after use. Sebum measurements were taken of the entire face using a Janus device. The T-zone area was designated and analyzed in the facial image taken image and used as sebum evaluation data. On the analyzed image, sebum is displayed as red dots (oxidized sebum), and it means that sebum is improved as the number of red dots decreases.

(Mean±SD) division ea Before use 123.10±133.24 2 weeks after use 101.35±109.45 4 weeks after use 116.90±130.35

As shown in Table 3, the sebum measurement values were 123.10 ± 133.24 before use, 101.35 ± 109.45 after 2 weeks of use, and 116.90 ± 130.35 after 4 weeks of use. As a result of post-test according to the normality test, the sebum measurement value significantly decreased after 4 weeks of use compared to before use.

Example 5: scalp oil and keratin improvement effect

To check the degree of oiliness and keratin improvement of the scalp The degree was measured by the following two methods. First of all, in order to check the scalp keratin improvement effect, the scalp keratin was magnified using an Aramo TS (AramHuvis, Korea) 60x lens, and then, using the image, two testers took 7 steps (1, weak/ Clean ~ 7, severe / dirty) scalp keratin status was evaluated. The degree of improvement was measured by comparing before use, after 2 weeks of use, and after 4 weeks of use.

The measured value of the scalp oil was 3.82 before use, 2.46 after 2 weeks of use, and 2.11 after 4 weeks of use, which was found to significantly reduce scalp keratin. The results are shown in Table 4.

Measures SD SEM Degree of reduction (%) Before treatment 3.82 0.58 0.15 after 2 weeks 2.46 0.69 0.12 35.45 4 weeks later 2.11 0.47 0.13 44.69

Next, the scalp oil content by photometric measurement was measured using Sebumeter SM810 (Courage-Khazaka eletronic GmbH, Germany). The measurement method was carried out in the same manner as in Example 4. The results are shown in Table 5.

(Mean±SD) division ㎍/㎠ Before use 124.38 ± 76.25 2 weeks after use 93.62 ± 38.51 4 weeks after use 60.97 ± 80.34

As shown in Table 5, the measured values of the oil content of the scalp were 124.38 ± 76.25 before use, 93.62 ± 38.51 after 2 weeks of use, and 60.97 ± 80.34 after 4 weeks of use. As a result of post-test according to the normality test, the measured value of oil content decreased significantly (p<0.05) after 4 weeks of use compared to before use.

Example 6: Skin safety test

In order to test the skin safety of external preparations for skin containing redwood fruit extract, the degree of skin irritation was measured by the following method. Subjective skin irritation and objective skin irritation were evaluated by the tester's observation at 2 and 4 weeks after product use. As a result of the safety test, no adverse skin reactions were observed in all subjects. The results are shown in Table 6.

Symptom 2 weeks 4 weeks Subjective stimulation itch 0 0 Stinging pain 0 0 Burning 0 0 Tingling 0 0 Stiffness 0 0 strain 0 0 Sore eyes 0 0 Tears remain 0 0 Etc 0 0 Objective stimulation Erythema 0 0 edema 0 0 Scale 0 0 papule 0 0 Etc 0 0 Total number of adverse reactions 0 0

As a result of the skin safety test, there were no subjects showing irritation in all items, so the composition was judged to be safe for application to the skin.

Formulation Example 1: Cosmetic formulation

1-1. Flexible lotion

ingredient weight% Red tree fruit extract 0.05 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 ethanol 10.0 Triethanolamine 0.1 Preservatives, trace pigments, trace flavors and trace purified water 82.75 sum 100.0

1-2. Nutritional lotion

ingredient weight% Red tree fruit extract 0.05 Beeswax 4.0 Polysorbate 60 1.5 Sorbitansquioleate 0.5 Floating paraffin 5.0 Squalane 5.0 Caprylic/Capric Triglyceride 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Triethanolamine 0.2 Preservatives, trace pigments, trace flavors and trace purified water 69.65 sum 100.0

1-3. Nourishing cream

ingredient weight% Red tree fruit extract 0.05 Beeswax 10.0 Polysorbate 60 1.5 Sorbitansquioleate 0.5 Floating paraffin 10.0 Squalane 5.0 Caprylic/Capric Triglyceride 5.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, trace pigments, trace flavors and trace purified water 56.75 sum 100.0

1-4. Massage cream

ingredient weight% Red tree fruit extract 0.05 Beeswax 10.0 Polysorbate 60 1.5 Sorbitansquioleate 0.8 Floating paraffin 40.0 Squalane 5.0 Caprylic/Capric Triglyceride 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, trace pigments, trace flavors and trace purified water 27.45 sum 100.0

1-5. pack

ingredient weight% Red tree fruit extract 0.05 Polyvinyl alcohol 13.0 Sodium carboxymethylcellulose 0.2 Allantoin 0.1 ethanol 5.0 Nonylphenyl ether 0.3 Preservatives, trace pigments, trace flavors and trace purified water 81.35 sum 100.0

Formulation Example 2: Pharmaceutical formulation

2-1. Preparation of powder

ingredient Content (g) Red tree fruit extract 2 Lactose One

The above ingredients were mixed and filled in an airtight cloth to prepare a powder.

2-2. Preparation of tablets

ingredient Content(mg) Red tree fruit extract 100 Corn starch 100 Lactose 100 Magnesium stearate 2

After mixing the above ingredients, tablets were prepared by tableting according to a conventional tablet preparation method.

2-3. Preparation of capsules

ingredient Content(mg) Red tree fruit extract 100 Corn starch 100 Lactose 100 Magnesium stearate 2

After mixing the above ingredients, a gelatin capsule was filled according to a conventional capsule preparation method to prepare a capsule formulation.

Claims (5)

A cosmetic composition for suppressing sebum secretion containing the Rhus Semialata M. fruit extract as an active ingredient. The method of claim 1,
A cosmetic composition for suppressing sebum secretion, characterized in that the suppression of sebum secretion is caused by inhibition of the differentiation of sebaceous cells. A cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis comprising the cosmetic composition for suppressing sebum secretion according to claim 1. The method of claim 3,
The cosmetic composition is any one of the group consisting of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, and spray. A cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis, characterized in that. Rhus Semialata M. A pharmaceutical composition for preventing or treating seborrheic dermatosis by suppressing sebum secretion, containing fruit extract as an active ingredient.

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