KR20200063856A - Composition for reducing sebum secretion comprising Rhus Semialata M. Fruit Extracts - Google Patents

Abstract

The present invention relates to a composition for inhibiting sebum secretion comprising an extract of Rhus semialata M. fruits. According to the present invention, the composition including the extract of the Rhus semialata M. fruits inhibits differentiation of sebum cells to inhibit excessive sebum secretion, thereby providing an effect of preventing, mitigating, or treating pore expansion or seborrheic dermatitis caused by sebum. Moreover, the composition does not provide skin irritation and cytotoxicity and is effective to inhibit sebum secretion while providing excellent stability for a human body, thereby being safely used as an active ingredient of a cosmetic or pharmaceutical composition for preventing, mitigating, or treating pore expansion or seborrheic dermatitis.

Description

Composition for reducing sebum secretion containing redwood fruit extract {Composition for reducing sebum secretion comprising Rhus Semialata M. Fruit Extracts}

The present invention relates to a composition for inhibiting sebum secretion comprising an extract of Rhus Semialata M. as an active ingredient, and more specifically, inhibiting sebum differentiation to prevent pore expansion or seborrheic dermatosis caused by sebum hypersecretion, The present invention relates to a cosmetic or pharmaceutical composition comprising an extract of red tree fruit that can be improved or treated as an active ingredient.

Sebum forms a thin sebum layer on the skin surface to prevent external invasion and to prevent skin evaporation, thereby protecting the skin. Sebum is produced from sebocytes present in the skin. The main mechanism of sebum production known to date is through the IGF-1/PI3K/Akt pathway upon stimulation of insulin or insulin-like growth factor-1 (IGF-1). It has been reported that the expression of SREBPs increases, leading to the process of lipogenesis. In the regulation of sebum production, when AMPK is activated through the AMPK-SREBP-1 signaling pathway in sebum cells, signals are sequentially activated through the IGF-1/PI3K/Akt pathway, thereby suppressing SREBPs expression, thereby reducing lipogenesis (Smith TM, Cong Z, Gilliland KL et al. Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1, J Invest Dermatol, 2006, 126: 1226-1232). UV rays, cortisol, and male hormones are known as factors that promote sebum production.

As sebum secretion increases, the shine and pores on the face increase, making the skin texture look rough and thick, making the skin look dull and darker and darker. When sebum reacts with an external stimulus such as air or ultraviolet light, a black head is generated through an oxidation reaction, and pores become more prominent. Seborrhea is a disease seen in various age groups and is known to be caused by excessive sebum secretion as well as skin microorganisms (Evidence Based Dermatology 2nd edition 2008;164-170). Until now, most researches on improving the symptoms of seborrheic skin have been conducted to suppress fungi present in the skin. In fact, when the vitamin A derivative drug isotretinoin, which affects sebaceous secretion cells, is used, inhibition of sebum secretion cell proliferation and sebum secretion have been confirmed both in vitro and in vivo , and clinical symptoms due to sebum hypersecretion are also improved. It has been reported (Int J Dermatol. 2017 Jan;56(1):80-85; Dermatology. 1998;196(1):21-31.).

On the other hand, Rhus Semialata M. is a deciduous tree belonging to the Sumacaceae family, and is mainly distributed in Northeast Asia such as Korea, China, and Japan. In addition, the red fruit is mature in October, and is used as a bitter to enter the manufacturing of sour and salty tofu. do. Regarding the efficacy of redwood, Korean Registered Patent No. 10-1617152 cosmetic composition containing the red ripe fruit extract as an active ingredient, Korean Registered Patent No. 10-0997641, a cosmetic composition containing the active ingredient of the molecularly encapsulated redwood extract fermentation, Korea Patent registration No. 10-0872454 There is a method for extracting functional cosmetic ingredients from plants, etc., and the contents of the activity of the dhammarane triterpene compounds isolated from redwood are registered in Korea Patent No. 10-0873222. And a composition for preventing, improving and treating oxidative stress, a new anticancer active triterpene compound, and a manufacturing method therefor. However, there has been no report on the composition including the above-mentioned patent document to have pore expansion and seborrheic skin prevention effect through the sebum secretion inhibiting effect of the red berries extract.

Accordingly, the present inventors searched for candidate substances that alleviate sebaceous growth through the mechanism of inhibiting sebum production, and target natural substances to prevent sebaceous dermatosis and pore enlargement caused by sebum hypersecretion. During the research, it was confirmed that the red fruit extract inhibits sedimentation of sebaceous cells, thereby inhibiting sebum production and reducing sebaceous secretion in clinical practice, thereby preventing pores caused by sebaceous hypersecretion and preventing seborrheic dermatosis. The present invention has been completed.

The technical problem to be solved in the present invention is to provide a composition for inhibiting sebaceous secretion, which includes an extract of Rhus Semialata M. fruit as an active ingredient.

Another technical problem to be solved in the present invention is to provide a cosmetic composition for preventing or improving pore enlargement or seborrheic dermatosis, which includes the red berries extract as an active ingredient.

Another technical problem to be solved in the present invention is to provide a pharmaceutical composition for the prevention or treatment of pore expansion or seborrheic dermatosis, which includes the red fruit extract as an active ingredient.

In order to solve the above technical problem, the present invention is to provide a composition for inhibiting sebaceous secretion, which contains the red fruit extract as an active ingredient.

In order to solve the above other technical problems, the present invention is to provide a cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis comprising the composition for inhibiting sebum secretion.

In order to solve the above other technical problems, the present invention is to provide a pharmaceutical composition for preventing or treating pore expansion or seborrheic dermatosis comprising the composition for inhibiting sebum secretion.

The term "extract" of the present invention refers to a formulation in which a crude drug is squeezed into an appropriate leach solution and concentrated by evaporating the leach solution, but is not limited thereto, but an extract obtained by an extraction treatment, a dilution or concentrate of the extract, or an extract It may be a dried product obtained by drying, a crude product or a purified product thereof.

In the present invention, the red fruit extract may be extracted using a conventional solvent known in the art, and the extracted liquid may be used in a liquid form or concentrated and/or dried. At this time, water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.) as the solvent, a mixed solvent of the lower alcohol and water, acetone, ethyl acetate, chloroform, or 1,3- Any one of butylene glycol can be used. Preferably, it can be extracted using methanol, ethanol or butanol. However, it is not particularly limited, and the extraction degree and loss degree of the active ingredient of the extract may differ depending on the organic solvent to be extracted, so it is preferable to select and use an appropriate organic solvent.

Examples of the extraction method include, but are not limited to, cold needle extraction, ultrasonic extraction, reflux cooling extraction, and the like, and are preferably performed by ultrasonic extraction.

In addition, the red fruit extract can also be obtained through a conventional purification process in addition to the extraction method by the extraction solvent. For example, through various purification methods additionally performed, such as separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity) Through the obtained fractions, it is also possible to obtain red berries extract.

According to one specific embodiment of the present invention, after drying and grinding the red berries, 0.5 to 20 times the weight of the dried sample, preferably 1 to 15 times the amount of C1 to C4 such as water, ethanol, methanol, etc. Using extraction methods such as stirring extraction, hot water extraction, cold needle extraction, reflux cooling extraction, or ultrasonic extraction for about 20 to 70 hours, preferably 40 to 50 hours at a high temperature using a lower alcohol or a mixed solvent of water and ethanol. , Preferably, the extract obtained after hot water extraction can be filtered, concentrated under reduced pressure, or dried to obtain a red fruit extract.

In the present invention, the red fruit extract includes all extracts, fractions and refinements obtained from each step of extraction, fractionation or purification, their diluents, concentrates or dried products.

The composition for inhibiting sebum secretion comprising the red fruit extract of the present invention as an active ingredient comprises 0.0001 to 20.0 wt%, preferably 0.001 to 10.0 wt%, of the red berries extract based on the total composition weight. When the content of the extract of red berries is less than 0.0001% by weight, the effect of inhibiting sebum secretion cannot be expected, and when it exceeds 20.0% by weight, the amount of suppression of sebum secretion according to the increase in content is negligible, and difficulty occurs in manufacturing a pharmaceutical formulation .

In one specific embodiment, a cosmetic composition or pharmaceutical composition for preventing, improving or treating pore expansion or seborrheic dermatosis caused by sebaceous hypersecretion by inhibiting the differentiation of sebaceous cells containing the red fruit extract of the present invention as an active ingredient It can be used as a composition.

The cosmetic composition comprising the red berries extract of the present invention as an active ingredient comprises 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight of the red berries extract based on the total cosmetic composition weight. When the content of the extract of the red berries is less than 0.0001% by weight, it is impossible to expect an effect to prevent or improve pore enlargement or seborrheic dermatosis, and when it exceeds 20.0% by weight, difficulty occurs in preparing a cosmetic formulation.

The cosmetic composition may further include components commonly used in cosmetic compositions in addition to the red berries extract. For example, it may include conventional adjuvants and carriers, such as antioxidants, stabilizers, solubilizers, vitamins, pigments, and fragrances.

The cosmetic composition may be prepared in any formulation conventionally manufactured in the art. For example, it can be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray, and the like. More specifically, it can be prepared in a formulation such as nutrition cream, converging lotion, soft lotion, lotion, essence, nutrition gel or massage cream. However, it is not particularly limited to this.

When the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. are used as carrier components. Can be used.

When the formulation of the cosmetic composition is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, Propellants such as propane/butane or dimethyl ether.

When the formulation of the cosmetic composition is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent may be used as a carrier component. For example, fatty acid esters of water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan can be used. have.

When the formulation of the cosmetic composition is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the cosmetic composition is a surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acids as carrier components Amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

More specifically, the present invention provides a pharmaceutical composition effective in preventing or treating pore expansion or seborrheic dermatosis by suppressing the differentiation of sebaceous cells by including the red fruit extract as an active ingredient.

The pharmaceutical composition comprising the red berries extract of the present invention as an active ingredient comprises 0.0001 to 20.0% by weight, preferably 0.001 to 10.0% by weight of the red berries extract based on the total cosmetic composition weight. When the content of the red berries extract is less than 0.0001% by weight, the prevention or treatment effect of pore enlargement or seborrheic dermatosis cannot be expected, and when it exceeds 20.0% by weight, the increase in the effect according to the increase in content is negligible and a pharmaceutical formulation is prepared. Difficulty occurs.

The pharmaceutical composition may further include a carrier, which is generally acceptable for the pharmaceutical composition, in addition to the red berries extract.

Carriers commonly accepted in the pharmaceutical composition are those commonly used in formulation, such as carbohydrate compounds (eg lactose, amylose, dextrose, sucrose, sorbitol, mannitol, starch, cellulose, etc.), acacia rubber, phosphoric acid Calcium, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, salt solution, alcohol, gum arabic, vegetable oils (e.g. corn oil, cotton seed oil, soy milk, olive oil, Coconut oil), polyethylene glycol, methyl cellulose, methylhydroxy benzoate, propylhydroxy benzoate, talc, magnesium stearate and mineral oil, and the like.

The pharmaceutical composition of the present invention may further include a lubricant, a wetting agent, a sweetener, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, etc. in addition to the above components. Suitable pharmaceutically acceptable carriers and formulations are described in detail in Remington's Pharmaceutical Sciences (19th ed., 1995).

The pharmaceutical composition of the present invention can be applied by oral or parenteral administration to mammals such as rats, mice, livestock, and humans, preferably parenteral administration, more preferably topical application by application Can be applied in a manner.

Suitable dosages of the pharmaceutical compositions can be variously prescribed by factors such as formulation method, mode of administration, patient's age, weight, sex, morbidity, food, time of administration, route of administration, rate of excretion, and response sensitivity. have. The oral dosage of the pharmaceutical composition of the present invention is within the range of 0.001-300 mg/kg (weight) on an adult basis. In addition, in the case of an external preparation, it is good to apply for 1 to 5 times a day in an amount of 1.0 to 3.0 ml on an adult basis and continue for at least 1 month. However, the dosage is not intended to limit the scope of the present invention.

The cosmetic or pharmaceutical composition comprising the red berries extract of the present invention as an active ingredient suppresses the differentiation of sebaceous cells of an individual by intra-individual administration, subcutaneous administration or local administration by application, and prevents over-secretion of sebum to expand pores or It has the advantage of achieving the purpose of alleviating, improving, preventing, improving or treating seborrheic dermatosis.

In one specific embodiment, the present invention is a method of improving the pore expansion or seborrheic dermatosis by administering a composition comprising a red berries extract as an active ingredient to an individual to suppress the differentiation of sebaceous cells and prevent over-secretion of sebum. Provides its use.

The composition administered to the subject of the present invention has an effect of improving or treating pore expansion or seborrheic dermatosis by inhibiting the differentiation of sebaceous cells and preventing over-secretion of sebum as described above.

In the present invention, the term "individual" refers to monkeys, cows, horses, pigs, sheep, dogs, cats, rats, mice, including humans with a condition or disease in which symptoms can be improved by administering the composition of the present invention, It means a mammal such as a chimpanzee.

In the present invention, the term "improvement" means (a) suppression of development, (b) alleviation, and (c) elimination of pores or seborrheic dermatosis caused by hyperdigestion of sebum in an individual.

On the other hand, the red tree fruit extract of the present invention is a natural extract that has no skin irritation and cytotoxicity and has excellent human stability, and has little side effects on the human body. It can be safely used as an active ingredient in cosmetic or pharmaceutical compositions for prevention, improvement or treatment of.

According to the present invention, the composition of the present invention comprising the red fruit extract has the effect of preventing, improving or treating pore expansion or seborrheic dermatosis caused by sebum by suppressing sebaceous hypersecretion by inhibiting differentiation of sebaceous cells. In addition, since the composition has no skin irritation and cytotoxicity and has excellent human stability and is very effective in suppressing sebum secretion, it can be safely used as an active ingredient in cosmetic or pharmaceutical compositions for preventing or improving pore expansion or seborrheic dermatosis. have.

Figure 1 shows the degree of sebum secretion suppression after the treatment of red berries.

Hereinafter, examples and the like will be described in detail to help understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be interpreted as being limited to the following examples. The embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

Example 1: Preparation of red berries extract

After washing and drying 1 kg of red berries, pulverized and powdered, 1 L of purified water was added to 20 g of powder, and hot water was extracted from a sterilizer. The supernatant was concentrated using a concentrator, and then lyophilized to powder. The powdered extract was dissolved in sterilized distilled water at a concentration of 100 mg/mL, and then used in an experiment after passing through a 0.2 μm pore size water-soluble injection filter.

Example 2: Preparation of an external preparation for skin including the extract of red berries

In order to measure the skin sebum secretion inhibitory effect of the red fruit extract, a skin external preparation containing the red berries extract with the ingredients and contents of Table 1 below was prepared, and then skin safety and sebum secretion inhibition efficacy tests were performed. First, purified water, glycerin and butylene glycol were mixed and dissolved at 70°C (water part), and the three components and the remaining ingredients were dissolved at 70°C (oil part). The oil part was added to the water part, stirred and emulsified with a homomixer (Tokushu Kika, Japan), and after removing air bubbles, it was cooled to room temperature to prepare an external preparation for skin.

ingredient content (%) Red berries
External preparation for skin Purified water 72.05 Butylene glycol 4.0 glycerin 8.0 Redwood fruit extract 0.05 Caprylic capri triglyceride 8.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Cetearyl alcohol 1.0 Gross weight 100

Example 3: Sebum secretion inhibitory efficacy test

In order to measure the effect of inhibiting sebum secretion of the extract prepared in Example 1, the degree of inhibition of sebum production was measured through the degree of inhibition of lipid droplet formation in sebum cells (human sebocyte, Cellprogen, USA). Specifically, sebum cells were seeded and cultured in a collagen-coated 24 well-plate at 2 x 10 ³ cells/well, and then treated with 20 nM of insulin that induces differentiation of sebum cells after pre-treatment of the red berries extract. After treatment, the cells were cultured for 8 days, and then fat was stained with nile red, which stained the fat in the cells with red. As a result, it could be confirmed that fat-differentiated cells were normalized due to a noticeable increase in fat-stained cells in the insulin 20 nM-treated group compared to the negative control group that did not process anything. In the conditions treated with the red berries extract, it was possible to observe the results of effectively inhibiting fat differentiation. The results are shown in FIG. 1.

Figure 1 shows the degree of sebum secretion suppression after the treatment of red berries.

Example 4: Measurement of the activity of reducing the oil content by the extract composition of red berries

In order to confirm the change in the oil content by the red fruit extract, the value of the red skin fruit extract prepared in Example 2 was measured before, after two weeks of use and after four weeks of use. The oil content was measured by the Sebumeter SM810 (Courage-Khazaka eletronic GmbH, Germany), which was the T-zone site. The measurement was performed once, and it was measured for 20 seconds and used as an evaluation data for skin oil content. Sebumeter is a device that measures the amount of sebum obtained by contacting a special semi-transparent lipid absorbing tape (sebumeter cassette) to the skin (about 20 seconds) by the amount of oil per unit area (µg sebum/cm ² ) using optical metric. The measured value and oil content are proportional.

(Mean±SD) division ㎍/㎠ Before use 142.39 ± 57.80 2 weeks after use 106.23 ± 51.38 4 weeks after use 72.54 ± 29.91

As shown in Table 2, the measured oil content of the rice bran was 142.39 before use, 106.23 after 2 weeks of use, and 72.54 after 4 weeks of use. As a result of post-test according to the normality test, the measured oil content decreased significantly after 4 weeks of use compared to before.

In order to confirm the sebum change caused by the use of the red skin fruit external preparation, ea values were measured before use, 2 weeks after use, and 4 weeks after use. Sebum measurements were taken on the entire face using a Janus device. The T-zone region was designated and analyzed in the image of the face image, and used as sebum evaluation data. On the analyzed image, sebum is marked with red dots (oxidized sebum), which means that as the number of red dots decreases, sebum improves.

(Mean±SD) division ea Before use 123.10±133.24 2 weeks after use 101.35±109.45 4 weeks after use 116.90±130.35

As shown in Table 3, the sebum measurements were 123.10 ± 133.24 before use, 101.35 ± 109.45 after 2 weeks of use, and 116.90 ± 130.35 after 4 weeks of use. As a result of post-testing according to the normality test, the sebum measurement was significantly reduced after 4 weeks of use compared to before use.

Example 5: Scalp oil and keratin improvement effect

To check the improvement of oil and keratin in the scalp, the degree was measured in the following two ways. First, in order to check the effect of improving scalp keratin, the scalp keratin was enlarged using a 60x lens, Aramo TS (AramHuvis, Korea), and then two examiners using the image were used in 7 steps (1, weak/ Cleanness ~ 7, severe/dirty) was evaluated for scalp keratinization. The degree of improvement was measured by comparing before, after 2 weeks of use, and after 4 weeks of use.

The scalp oil measurement was found to significantly decrease the scalp keratinization to 3.82 before use, 2.46 after 2 weeks of use, and 2.11 after 4 weeks of use. Table 4 shows the results.

Measures SD SEM Degree of reduction (%) Before processing 3.82 0.58 0.15 After two weeks 2.46 0.69 0.12 35.45 4 weeks later 2.11 0.47 0.13 44.69

Next, the scalp oil content by photometry was measured using Sebumeter SM810 (Courage-Khazaka eletronic GmbH, Germany). The measurement method was performed in the same way as in Example 4. Table 5 shows the results.

(Mean±SD) division ㎍/㎠ Before use 124.38 ± 76.25 2 weeks after use 93.62 ± 38.51 4 weeks after use 60.97 ± 80.34

As shown in Table 5, the measured oil content of the scalp was 124.38 ± 76.25 before use, 93.62 ± 38.51 after 2 weeks of use, and 60.97 ± 80.34 after 4 weeks of use. As a result of post-test according to the normality test, the measured value of oil content significantly decreased (p<0.05) after 4 weeks of use compared to before.

Example 6: Skin safety test

The skin irritation level was measured by the following method for the skin safety test of the external preparation for skin containing red berries extract. Subjective skin irritation and objective skin irritation by the observation of the investigator were evaluated at 2 and 4 weeks after product use. As a result of the safety test, no adverse skin reactions were observed in all subjects. Table 6 shows the results.

Symptom 2 weeks 4 weeks Subjective stimulation itch 0 0 Stinging pain 0 0 Burning 0 0 Tingling 0 0 Stiffness 0 0 strain 0 0 Itchy eyes 0 0 Tears remain 0 0 Other 0 0 Objective stimulation Erythema 0 0 edema 0 0 Human 0 0 papule 0 0 Other 0 0 Total number of adverse events 0 0

Since the skin safety test did not show any subjects exhibiting irritation in all items, the composition was judged to be safe for application to the skin.

Formulation Example 1: Cosmetic preparation

1-1. Flexible Cosmetics

ingredient weight% Redwood fruit extract 0.05 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxyvinyl polymer 0.1 ethanol 10.0 Triethanolamine 0.1 Preservatives, trace colorants, trace flavors and trace purified water 82.75 sum 100.0

1-2. Nutrition

ingredient weight% Redwood fruit extract 0.05 Wax 4.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Floating paraffin 5.0 Squalane 5.0 Caprylic/Capric Triglyceride 5.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Preservatives, trace colorants, trace flavors and trace purified water 69.65 sum 100.0

1-3. Nutrition cream

ingredient weight% Redwood fruit extract 0.05 Wax 10.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Floating paraffin 10.0 Squalane 5.0 Caprylic/Capric Triglyceride 5.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, trace colorants, trace flavors and trace purified water 56.75 sum 100.0

1-4. Massage cream

ingredient weight% Redwood fruit extract 0.05 Wax 10.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.8 Floating paraffin 40.0 Squalane 5.0 Caprylic/Capric Triglyceride 4.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 Preservatives, trace colorants, trace flavors and trace purified water 27.45 sum 100.0

1-5. pack

ingredient weight% Redwood fruit extract 0.05 Polyvinyl alcohol 13.0 Sodium carboxymethylcellulose 0.2 Allantoin 0.1 ethanol 5.0 Nonylphenyl ether 0.3 Preservatives, trace colorants, trace flavors and trace purified water 81.35 sum 100.0

Formulation Example 2: Pharmaceutical Formulation

2-1. Preparation of powder

ingredient Content (g) Redwood fruit extract 2 Lactose One

A powder was prepared by mixing the above components and filling the gas-tight fabric.

2-2. Preparation of tablets

ingredient Content (mg) Redwood fruit extract 100 Corn starch 100 Lactose 100 Magnesium stearate 2

After mixing the above components, tablets were prepared by tableting according to a conventional tablet manufacturing method.

2-3. Preparation of capsules

ingredient Content (mg) Redwood fruit extract 100 Corn starch 100 Lactose 100 Magnesium stearate 2

After mixing the above components, the capsules were prepared by filling the gelatin capsules according to a conventional capsule preparation method.

Claims (5)

Rhus Semialata M. A composition for inhibiting sebum secretion, which contains an extract of fruit as an active ingredient. According to claim 1,
Suppression of sebum secretion is a composition for inhibiting sebum secretion, characterized in that by suppressing the differentiation of sebum cells. A cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis, comprising the composition for inhibiting sebum secretion according to claim 1. The method of claim 3,
The cosmetic composition is any one of the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oil, powder foundations, emulsion foundations, wax foundations and sprays Cosmetic composition for preventing or improving pore expansion or seborrheic dermatosis, characterized by. A pharmaceutical composition for preventing or treating pore expansion or seborrheic dermatosis comprising the composition for inhibiting sebum secretion according to claim 1.

Images